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Xavier Leray

Chargé de Recherche INRAE
21
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  • 1040751
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Je suis chargé de recherche à l’Institut national de recherche pour l’agriculture, l’alimentation et l’environnement (INRAE), en poste depuis 2023 dans l’équipe *Biologie de l’œuf et Physiologie de la Poule* au laboratoire *Biologie des Oiseaux et Avicultures *situé à Nouzilly près de Tours. La ligne conductrice de mes travaux de recherche s’articule autour du transfert de molécules et de la transduction des signaux à travers les membranes biologiques en regard de leurs rôles physiologiques. J'étudie actuellement les processus de biominéralisation chez les oiseaux et plus particulièrement le système de transport de minéraux par voie vésiculaire par des approches d'imagerie et d'analyse expressionnelle.
I'm a permanent researcher at the French National Research Institute for Agriculture, Food and Environment (INRAE), where I was recruited in 2023 in the team *Biology of the Egg and Physiology of the Hen* at the laboratory *Biology of Birds and Aviculture* in Nouzilly near Tours, France. My research focuses on molecule transfer and signal transduction across biological membranes in relation to their physiological roles. I am currently working on biomineralization processes in birds and more specifically on the vesicular transport pathway of minerals by imaging and expression analysis.

Publications

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Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

Anil Annamneedi , Caroline Gora , Ana Dudas , Xavier Leray , Véronique Bozon
British Journal of Pharmacology, 2023, 2023, pp.1-24. ⟨10.1111/bph.16216⟩
Journal articles hal-04220553v1

Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance

Xavier Leray , Jacob Hilton , Kamsi Nwangwu , Alissa Becerril , Vedrana Mikusevic
eLife, 2022, 11, ⟨10.7554/eLife.74136⟩
Journal articles hal-04516368v1
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Arginine-selective modulation of the lysosomal transporter PQLC2 through a gate-tuning mechanism

Xavier Leray , Rossella Conti , Yan Li , Cécile Debacker , Florence Castelli
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (32), pp.e2025315118. ⟨10.1073/pnas.2025315118⟩
Journal articles hal-03320088v1

Neuronal Nicotinic Receptors Are Crucial for Tuning of E/I Balance in Prelimbic Cortex and for Decision-Making Processes

Elsa Pittaras , Alexis Faure , Xavier Leray , Elina Moraitopoulou , Arnaud Cressant
Frontiers in Psychiatry, 2016, 7, pp.171. ⟨10.3389/fpsyt.2016.00171⟩
Journal articles hal-01405237v1

Quinuclidine compounds differently act as agonists of Kenyon cell nicotinic acetylcholine receptors and induced distinct effect on insect ganglionic depolarizations

Monique Mathe-Allainmat , Daniel Swale , Xavier Leray , Yassine Benzidane , Jacques Lebreton
INVERTEBRATE NEUROSCIENCE, 2013, 13 (2), pp.167-177. ⟨10.1007/s10158-013-0160-2⟩
Journal articles hal-02142391v1

Pretreatment of the cockroach cercal afferent/giant interneuron synapses with nicotinoids and neonicotinoids differently affects acetylcholine and nicotine-induced ganglionic depolarizations

Benzidane Yassine , Xavier Leray , Charlotte Falaise , Sophie Quinchard , José Pedro Ceron-Carrasco
Invertebrate Neuroscience, 2013, 13 (2), pp.91-97. ⟨10.1007/s10158-013-0151-3⟩
Journal articles hal-02268785v1

Discussion Leader: Biology, Physiology and Pathology of Intracellular Channels/Transporters

Xavier Leray
Gordon Research Seminar on Organellar Channels and Transporters, Xiaoli Zhang and Dhondup Lhamo, Aug 2019, West Dover, VT, United States
Conference papers hal-04653720v1
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Watching living cells, the building blocks of life

Xavier Leray
Take Your Child To Work Day 2018, FAES@NIH, Apr 2018, Bethesda, MD, United States
Conference papers hal-04653634v1

Watching living cells, the building blocks of life

Xavier Leray
Take Your Child To Work Day 2017, FAES@NIH, Apr 2017, Bethesda, MD, United States
Conference papers hal-04653632v1

Functional properties of the lysosomal amino acid transporter PQLC2

Xavier Leray , Christine Anne , Anselm A Zdebik , Bruno Gasnier
Gordon Research Conference on Organellar Channels and Transporters, Haoxing Xu and Enrico Martinoia, Jun 2015, West Dover, VT, United States
Conference papers hal-04652976v1
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Investigating the interplay between PIKfyve and ClC-7 in lysosomal acidification and trafficking

Xavier Leray , Anowarul Amin , Mary Weston , Joseph Mindell
Gordon Research Conference on Organellar Channels and Transporters, Aug 2019, West Dover, VT, United States.
Conference poster hal-04653194v1
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Investigating the interplay between PIKfyve/PI(3,5)P2 and ClC-7 in lysosomal acidification and trafficking.

Xavier Leray , Anowarul Amin , Mary Weston , Joseph Mindell
63rd Annual Meeting of the Biophysical Society, Mar 2019, Baltimore, MD, United States. , 116 (3), pp.228a, 2019, ⟨10.1016/j.bpj.2018.11.1256⟩
Conference poster hal-04653246v1
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Investigating the interplay between PIKfyve/PI(3,5)P2 and ClC-7 in lysosomal acidification and trafficking

Xavier Leray , Anowarul Amin , Mary Weston , Joseph Mindell
Gordon Research Conference on Lysosomes and Endocytosis, Jun 2018, Andover, NH, United States.
Conference poster hal-04653165v1
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Unusual properties of the lysosomal amino acid transporter PQLC2

Xavier Leray , Yan Li , Anselm A Zdebik , Bruno Gasnier
60th Annual Meeting of the Biophysical Society, Feb 2016, Los angeles, CA, United States.
Conference poster hal-04653004v1
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Unusual properties of the lysosomal amino acid transporter PQLC2

Xavier Leray , Christine Anne , Yan Li , Anselm A Zdebik , Bruno Gasnier
Fifth International Cystinosis Research Symposium, Mar 2016, Irvine, CA, United States
Conference poster hal-04652904v1
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Functional properties of the lysosomal amino acid transporter PQLC2

Xavier Leray , Yan Li , Anselm A Zdebik , Bruno Gasnier
Gordon Research Conference (GRC) on Organellar Channels and Transporters, Jun 2015, West Dover, VT, United States
Conference poster hal-04652959v1
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Molecular mechanism of the lysosomal transporter PQLC2,a rate-limiting step in cysteamine therapy of cystinosis

Xavier Leray , Christine Anne , Anselm A Zdebik , Bruno Gasnier
Fourth International Cystinosis Research Symposium, Feb 2014, Irvine, CA, United States
Conference poster hal-04652928v1
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Identification and characterization of a new cationic amino acid transporter named PQ-Loop-Containing protein 2 (PQLC2)

Adrien Jezegou , Xavier Leray , Elisa Llinares , Christine Anne , Sylvie Kieffer-Jaquinod
19th European Study Group on Lysosomal Diseases (ESGLD) Workshop, Sep 2013, Seggau castle, Austria
Conference poster hal-04652798v1

Functional Study of Lysosomal Nutrient Transporters

Xavier Leray , Corinne Sagné , Bruno Gasnier
Bruno Gasnier; Michael X. Zhu. Ion and Molecule Transport in Lysosomes, CRC Press, 26 p, 2020, 9781138560390. ⟨10.1201/b22460⟩
Book sections hal-04521959v1