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Xavier Thuru

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Soluble TIM-3 as a biomarker of progression and therapeutic response in cancers and other of human diseases

Christian Bailly , Xavier Thuru , Laurence Goossens , Jean-François Goossens
Biochemical Pharmacology, 2023, 209, pp.115445. ⟨10.1016/j.bcp.2023.115445⟩
Journal articles hal-03990928v1

A Potential Off-Target Effect of the Wnt/β-Catenin Inhibitor KYA1797K: PD-L1 Binding and Checkpoint Inhibition

Xavier Thuru , Romain Magnez , Gérard Vergoten , Christian Bailly
Biomedicine hub = Biomed Hub, 2023, 8 (1), pp.1-9. ⟨10.1159/000528499⟩
Journal articles inserm-03990317v1
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Antioxidant Properties and Aldehyde Reactivity of PD-L1 Targeted Aryl-Pyrazolone Anticancer Agents

Natascha Leleu , Romain Regnault , Hania Ahouari , Raphael Le Biannic , Mostafa Kouach et al.
Molecules, 2022, Molecules, 27 (10), pp.3316. ⟨10.3390/molecules27103316⟩
Journal articles hal-03714935v1
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p65/RelA NF‐κB fragments generated by RIPK3 activity regulate tumorigenicity, cell metabolism, and stemness characteristics

Yasmine Touil , Céline Latreche‐carton , Hassiba El Bouazzati , Anne‐lucie Nugues , Nathalie Jouy et al.
Journal of Cellular Biochemistry, 2022, 123 (3), pp.543-556. ⟨10.1002/jcb.30198⟩
Journal articles hal-03641788v1
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A Phosphosite Mutant Approach on LRRK2 Links Phosphorylation and Dephosphorylation to Protective and Deleterious Markers, Respectively

Antoine Marchand , Alessia Sarchione , Panagiotis Athanasopoulos , Hélène Bauderlique-Le Roy , Liesel Goveas et al.
Cells, 2022, 11 (6), pp.1018. ⟨10.3390/cells11061018⟩
Journal articles inserm-03625821v1

Functional Analyses of Two Novel LRRK2 Pathogenic Variants in Familial Parkinson's Disease.

Ilda Coku , Eugénie Mutez , Sabiha Eddarkaoui , Sébastien Carrier , Antoine Marchand et al.
Movement Disorders, 2022, ⟨10.1002/mds.29124⟩
Journal articles hal-03703786v1

Direct interaction of TrkA/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells

Sarah Trouvilliez , Julien Cicero , Romain Lévêque , Léo Aubert , Cyril Corbet et al.
Journal of experimental & clinical cancer research, 2022, 41 (1), pp.110. ⟨10.1186/s13046-022-02314-4⟩
Journal articles hal-03641786v1

Microscale Thermophoresis as a Tool to Study Protein Interactions and Their Implication in Human Diseases

Romain Magnez , Christian Bailly , Xavier Thuru
International Journal of Molecular Sciences, 2022, 23 (14), pp.7672. ⟨10.3390/ijms23147672⟩
Journal articles hal-03857337v1

Drug Repurposing to Enhance Antitumor Response to PD-1/PD-L1 Immune Checkpoint Inhibitors

Xavier Thuru , Romain Magnez , Hassiba El-Bouazzati , Gérard Vergoten , Bruno Quesnel et al.
Cancers, 2022, 14 (14), pp.3368. ⟨10.3390/cancers14143368⟩
Journal articles hal-03857329v1

Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interaction

Raphaël Le Biannic , Romain Magnez , Frédérique Klupsch , Natascha Leleu-Chavain , Bryan Thiroux et al.
European Journal of Medicinal Chemistry, 2022, 236, pp.114343. ⟨10.1016/j.ejmech.2022.114343⟩
Journal articles hal-03641793v1

Modulation of the Gal-9/TIM-3 Immune Checkpoint with α-Lactose. Does Anomery of Lactose Matter?

Christian Bailly , Xavier Thuru , Bruno Quesnel
Cancers, 2021, 13 (24), pp.6365. ⟨10.3390/cancers13246365⟩
Journal articles hal-03641796v1
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Soluble Programmed Death Ligand-1 (sPD-L1): A Pool of Circulating Proteins Implicated in Health and Diseases

Christian Bailly , Xavier Thuru , Bruno Quesnel
Cancers, 2021, 13 (12), pp.3034. ⟨10.3390/cancers13123034⟩
Journal articles hal-03278429v1

The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis

Nicolas Stoup , Maxime Liberelle , Céline Schulz , Sumeyye Cavdarli , Romain Vasseur et al.
Cancers, 2021, 13 (22), pp.5746. ⟨10.3390/cancers13225746⟩
Journal articles hal-03641795v1

Properties and reactivity of the folic acid and folate photoproduct 6-formylpterin

Jean-François Goossens , Xavier Thuru , Christian Bailly
Free Radical Biology and Medicine, 2021, 171, pp.1-10. ⟨10.1016/j.freeradbiomed.2021.05.002⟩
Journal articles hal-03226670v1
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Tau Stabilizes Chromatin Compaction

Thomas Rico , Melissa Gilles , Alban Chauderlier , Thomas Comptdaer , Romain Magnez et al.
Frontiers in Cell and Developmental Biology, 2021, 9, pp.740550. ⟨10.3389/fcell.2021.740550⟩
Journal articles hal-03429442v1

Discovery of a cryptic site at the interface 2 of TEAD – Towards a new family of YAP/TAZ-TEAD inhibitors

Manon Sturbaut , Fabrice Bailly , Mathilde Coevoet , Pasquale Sileo , Martine Pugniere et al.
European Journal of Medicinal Chemistry, 2021, 226, pp.113835. ⟨10.1016/j.ejmech.2021.113835⟩
Journal articles hal-03429462v1

Aggressiveness potential of spontaneous canine mucosal melanoma can dictate distinct cancer stem cell compartment behaviors in regard to their initial size and expansion abilities

Yasmine S. Touil , Zacharie Segaoula , Xavier Thuru , Sylvie Zouitina , Dominique Tierny et al.
Stem Cells and Development, inPress, ⟨10.1089/scd.2019.0223⟩
Journal articles hal-02873700v1

Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands

Alina Ghinet , Xavier Thuru , Emilie Floquet , Joëlle Dubois , Amaury Farce et al.
Bioorganic Chemistry, 2020, 96, pp.103643. ⟨10.1016/j.bioorg.2020.103643⟩
Journal articles hal-02873632v1
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Measurement of Protein-Protein Interactions through Microscale Thermophoresis (MST)

Magnez Romain , Bryan Thiroux , Morgane Tardy , Bruno Quesnel , Xavier Thuru et al.
Bio-protocol , 2020, Bio-protocol, 10 (7), ⟨10.21769/bioprotoc.3574⟩
Journal articles hal-03185893v1

Chemical reactivity and uses of 1-phenyl-3-methyl-5-pyrazolone (PMP), also known as edaravone

Christian Bailly , Paul-Emile Hecquet , Mostafa Kouach , Xavier Thuru , Jean-Francois Goossens et al.
Bioorganic and Medicinal Chemistry, 2020, 28 (10), pp.115463. ⟨10.1016/j.bmc.2020.115463⟩
Journal articles hal-02873617v1

Combined cytotoxic chemotherapy and immunotherapy of cancer: modern times

Christian Bailly , Xavier Thuru , Bruno Quesnel
NAR Cancer, 2020, 2 (1), ⟨10.1093/narcan/zcaa002⟩
Journal articles hal-02873714v1
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MUC4-ErbB2 Oncogenic Complex: Binding studies using Microscale Thermophoresis

Maxime Liberelle , Romain Magnez , Xavier Thuru , Yamina Bencheikh , Séverine Ravez et al.
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-53099-0⟩
Journal articles hal-02407901v1

Exploring isoxazoles and pyrrolidinones decorated with the 4,6‐dimethoxy‐1,3,5‐triazine unit as human farnesyltransferase inhibitors

Emilie Floquet , Liliana Lucescu , Alina Ghinet , Sergiu Shova , Romain Magnez et al.
Archiv der Pharmazie / Chemistry in Life Sciences, 2019, 352 (5), pp.1800227. ⟨10.1002/ardp.201800227⟩
Journal articles hal-02873628v1
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Toward the Discovery of a Novel Class of YAP–TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP–TEAD Protein–Protein Interface

Floriane Gibault , Mathilde Coevoet , Manon Sturbaut , Amaury Farce , Nicolas Renault et al.
Cancers, 2018, 10 (5), pp.140. ⟨10.3390/cancers10050140⟩
Journal articles hal-02060686v1
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Isolation and characterization of two canine melanoma cell lines new models for comparative oncology

Zacharie Segaoula , Aline Primot , Frederic Lepretre , Benoit Hedan , Emmanuel Bouchaert et al.
BMC Cancer, 2018, 18 (1), pp.1219. ⟨10.1186/s12885-018-5114-y⟩
Journal articles hal-01972446v1

PD-1/PD-L1 binding studies using microscale thermophoresis

Romain Magnez , Bryan Thiroux , Solenne Taront , Zacharie Segaoula , Bruno Quesnel et al.
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-17963-1⟩
Journal articles hal-02873635v1
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Synthesis and Biological Evaluation of N -[2-(4-Hydroxyphenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide (ABT-751) Tricyclic Analogues as Antimitotic and Antivascular Agents with Potent in Vivo Antitumor Activity

Zacharie Segaoula , Julien Leclercq , Valérie Verones , Nathalie Flouquet , Marie Lecoeur et al.
Journal of Medicinal Chemistry, 2016, 59 (18), pp.8422-8440. ⟨10.1021/acs.jmedchem.6b00847⟩
Journal articles hal-02060584v1

Phase I Clinical Pharmacology Study of F14512, a New Polyamine-Vectorized Anticancer Drug, in Naturally Occurring Canine Lymphoma

D. Tierny , F. Serres , Z. Segaoula , I. Bemelmans , E. Bouchaert et al.
Clinical Cancer Research, 2015, 21 (23), pp.5314-5323. ⟨10.1158/1078-0432.ccr-14-3174⟩
Journal articles hal-02873640v1

Synthesis and biological evaluation of phenstatin metabolites

Alina Ghinet , Benoit Rigo , Jean-Pierre Hénichart , Delphine Le Broc-Ryckewaert , Jean Pommery et al.
Bioorganic and Medicinal Chemistry, 2011, 19 (20), pp.6042-6054. ⟨10.1016/j.bmc.2011.08.047⟩
Journal articles hal-02873643v1

Colonization of Mice by Candida albicans Is Promoted by Chemically Induced Colitis and Augments Inflammatory Responses through Galectin‐3

Samir Jawhara , Xavier Thuru , Annie Standaert‐vitse , Thierry Jouault , Serge Mordon et al.
Journal of Infectious Diseases, 2008, 197 (7), pp.972-980. ⟨10.1086/528990⟩
Journal articles hal-02873647v1

Peroxisome Proliferator-Activated Receptor Gamma Functions As An Antibacterial Factor

L. Peyrin-Biroulet , Xavier Thuru , C. Vignal , L. Dubuquoy , E. Merour et al.
Journal of Crohn's and Colitis Supplements, 2007, 1 (1), pp.2. ⟨10.1016/s1873-9954(07)70004-6⟩
Journal articles hal-02873659v1

micro-Opioid receptor activation prevents acute hepatic inflammation and cell death.

Dania Chakass , David Philippe , Edmone Erdual , Sébastien Dharancy , Mathilde Malapel et al.
Gut, 2007, 56 (7), pp.974-81. ⟨10.1136/gut.2006.105122⟩
Journal articles hal-00189969v1

C-reactive protein (CRP), a novel adipocytokine overexpressed in mesenteric fat in Crohnʼs disease

F. Gonzalez , L. Peyrin-Biroulet , C. Rousseaux , L. Dubuquoy , Xavier Thuru et al.
Inflammatory Bowel Diseases, 2007, 13 (supplement), pp.650. ⟨10.1097/00054725-200705001-00026⟩
Journal articles hal-02873652v1

P176 C-Reactive Protein (crp), a novel adipocytokine overexpressed in Mesenteric fat in Crohn's disease

F. Gonzalez , L. Peyrin-Biroulet , C. Rousseaux , Xavier Thuru , C. Decourcelle et al.
Journal of Crohn's and Colitis Supplements, 2007, 1 (1), pp.49. ⟨10.1016/s1873-9954(07)70188-x⟩
Journal articles hal-02873662v1

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors

Christel Rousseaux , Xavier Thuru , Agathe Gelot , Nicolas Barnich , Christel Neut et al.
Nature Medicine, 2007, 13 (1), pp.35-37. ⟨10.1038/nm1521⟩
Journal articles hal-02667010v1

C-reactive protein (CRP), a novel adipocytokine overexpressed in mesenteric fat in Crohnʼs disease

F Gonzalez , L Peyrin-Biroulet , C Rousseaux , Laurent Dubuquoy , Xavier Thuru et al.
Inflammatory Bowel Diseases, 2007, Inflammatory Bowel Diseases, 13 (5), pp.650. ⟨10.1097/00054725-200705005-00026⟩
Journal articles hal-03113336v1

PPAR as a new therapeutic target in inflammatory bowel diseases

Xavier Thuru , L. Dubuquoy
Gut, 2006, 55 (9), pp.1341-1349. ⟨10.1136/gut.2006.093484⟩
Journal articles hal-02873664v1

Mu opioid receptor expression is increased in inflammatory bowel diseases: implications for homeostatic intestinal inflammation

Xavier Thuru , D Philippe
Gut, 2006, 55 (6), pp.815-823. ⟨10.1136/gut.2005.080887⟩
Journal articles hal-02873665v1

Cannabis : des nouvelles fonctions anti-diarrhéiques et anti-cancéreuses

Pierre Desreumaux , Xavier Thuru , David Philippe
Gastroentérologie Clinique et Biologique / Research and Clinics in Hepatology and Gastroenterology, 2004, 28 (1), pp.97. ⟨10.1016/s0399-8320(04)94859-2⟩
Journal articles hal-02873668v1

Induction of mu opioid and cannabinoid receptors by probiotics: A new mechanism of regulation of visceral pain perception

C. Rousseaux , Xavier Thuru , A. Gelot , N. Barnich , C. Neut et al.
5. Annual Advances in the Inflammatory Bowel Diseases, Dec 2006, Miami (Florida), United States. 13 (Supplement 5), pp.652-653, 2007, Abstracts from the 2006 CCFA National Research and Clinical Conference, 5th Annual Advances in the Inflammatory Bowel Diseases, Dec. 1‐3, 2006, Miami, FL. ⟨10.1097/00054725-200705001-00035⟩
Conference poster hal-02873654v1