Yann GUEGUEN

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Publications

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Uranium and Kidney Cancer: Insights from Genetically Engineered Mouse Models in the UKCAN Project

Castro Laurie De , Claude Olivier , Brisset Myriam , Gillot Clara , Manoury Annabelle et al.
Eurotox2024 - 58th congress of the European Societies of Toxicology, Eurotox, Sep 2024, Copenhagen, Denmark. ⟨10.1016/S0378-4274(24)01100-7⟩
Communication dans un congrès irsn-04907916 v1
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Experimental studies of uranium renal toxicology in low doses exposures

Yann Guéguen , Marie Frerejacques , Annabelle Manoury , David Suhard , Olivier Claude et al.
ICRR2023 -17th International Congress of Radiation Research, ICRR, Aug 2023, Montreal, Canada
Communication dans un congrès irsn-04907833 v1
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ETUDES EXPERIMENTALES DE LA TOXICOLOGIE DE L'URANIUM LORS D'EXPOSITIONS A DE FAIBLES DOSES

Yann Guéguen
Au coeur de l'Uranium - Journées techniques de la SFRP, Section Environnement de la Société Française de Radioprotection, Feb 2023, Paris, France
Communication dans un congrès irsn-04907745 v1

Renal toxicity and biokinetics models after repeated uranium instillation

Chrystelle Ibanez , Laurie de Castro , Annabelle Manoury , Bastien Simoneau , Christelle Elie et al.
56th Congress European Societies of Toxicology, EUROTOX Congress 2021, du 27/09/2021 au 01/10/2021,, Sep 2021, VIRTUAL, Denmark. pp.S194, ⟨10.1016/S0378-4274(21)00697-4⟩
Communication dans un congrès hal-03716880 v1

Renal toxicity and biokinetics models after repeated uranium instillation

Laurence Roy , Estelle Davesne , Bastien Simoneau , Annabelle Manoury , Christelle Elie et al.
15th International Congress ofthe International Radiation Protection Association, IRPA - International Radiation Protection Association; KARP - Korean Association for Radiation Protection, Jan 2021, Seoul, South Korea
Communication dans un congrès hal-04100195 v1
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In vivo comparison between two nephrotoxic agents, sodium fluoride and uranyl nitrate: phenotypic aspects and molecular mechanisms involved

Alice Bontemps , Laurine Conquet , Christelle Elie , Victor Magneron , Celine Gloaguen et al.
International Conference on the Health Effects of Incorporated Radionuclides, HEIR, Oct 2019, FONTENAY-AUX-ROSES, France. pp.05004, ⟨10.1051/bioconf/20191405004⟩
Communication dans un congrès hal-02635732 v1

Studying biomarkers reflecting the adverse outcome pathways from exposures to diseases using molecular epidemiology: example of the molecular epidemiology protocol developed as part of the Concerted Uranium Research in Europe (CURE) project

Maria Gomolka , Olivier Laurent , Laurence Roy , Sabine Hornhardt , Christophe Badie et al.
Eurpean Radiation Protection Week, ERPW 2019, Oct 2019, STOCKHOLM, Sweden
Communication dans un congrès hal-03150525 v1

Toxicologie predictive: les voies du futur

Ph Detilleux , L Vallier , C Legallais , E Leclerc , M Prot J et al.
Congrès de la SPTC - Société de Pharmaco-Toxicologie Cellulaire, May 2010, Paris, France
Communication dans un congrès hal-01122677 v1
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Renal toxicity and biokinetics models after repeated uranium instillation

Laurie de Castro , Annabelle Manoury , Olivier Claude , Bastien Simoneau , V. Monceau et al.
Scientific Reports, 2023, 13 (1), pp.4111. ⟨10.1038/s41598-023-31073-1⟩
Article dans une revue irsn-04032713 v1
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Overview of Traditional and Environmental Factors Related to Bone Health

Juan Carlos Rubio-Gutierrez , Pablo Mendez-Hernández , Yann Guéguen , Pierre Galichon , Marcela Tamayo-Ortiz et al.
Environmental Science and Pollution Research, 2022, 29 (21), pp.31042-31058. ⟨10.1007/s11356-022-19024-1⟩
Article dans une revue hal-03607546 v1
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Review of Knowledge of Uranium-Induced Kidney Toxicity for the Development of an Adverse Outcome Pathway to Renal Impairment

Yann Guéguen , Marie Frerejacques
International Journal of Molecular Sciences, 2022, 23 (8), pp.4397. ⟨10.3390/ijms23084397⟩
Article dans une revue irsn-03959341 v1
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Renal adaptive response to exposure to low doses of uranyl nitrate and sodium fluoride in mice

Alice Bontemps , Victor Magneron , Laurine Conquet , Christelle Elie , Celine Gloaguen et al.
Journal of Trace Elements in Medicine and Biology, 2021, 64, pp.126708. ⟨10.1016/j.jtemb.2020.126708⟩
Article dans une revue hal-03471501 v1
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In vivo comparison of the phenotypic aspects and molecular mechanisms of two nephrotoxic agents, sodium fluoride and uranyl nitrate

A. Bontemps , L. Conquet , C. Elie , V. Magneron , C. Gloaguen et al.
International Journal of Environmental Research and Public Health, 2019, 16 (7), pp.1136. ⟨10.3390/ijerph16071136⟩
Article dans une revue hal-02524211 v1
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Adaptive responses to low doses of radiation or chemicals their cellular and molecular mechanisms

Y. Guéguen , A. Bontemps , T.G. Ebrahimian
Cellular and Molecular Life Sciences, 2019, 76 (7), pp.1255-1273. ⟨10.1007/s00018-018-2987-5⟩
Article dans une revue hal-02524214 v1
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Chronic Exposure to External Low-Dose Gamma Radiation Induces an Increase in Anti-inflammatory and Anti-oxidative Parameters Resulting in Atherosclerotic Plaque Size Reduction in ApoE–/– Mice

Teni Ebrahimian Chiusa , Louison Beugnies , Joel Surette , Nick Priest , Yann Gueguen et al.
Radiation Research, 2018, 189 (2), pp.187-196. ⟨10.1667/RR14823.1⟩
Article dans une revue hal-02457222 v1

In vivo animal studies help achieve international consensus on standards and guidelines for health risk estimates for chronic exposure to low levels of tritium in drinking water

Y. Guéguen , N.D. Priest , I. Dublineau , L. Bannister , M. Benderitter et al.
Environmental and Molecular Mutagenesis, 2018, 59 (7), pp.586-594. ⟨10.1002/em.22200⟩
Article dans une revue hal-02874507 v1
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Intracellular uranium distribution : Comparison of cryogenic fixation versus chemical fixation methods for SIMS analysis

D. Suhard , C. Tessier , Line Manens , F. Rebière , K. Tack et al.
Microscopy Research and Technique, 2018, 81 (8), pp.855-864. ⟨10.1002/jemt.23047⟩
Article dans une revue hal-02874521 v1

Biomarkers for Uranium Risk Assessment for the Development of the CURE (Concerted Uranium Research in Europe) Molecular Epidemiological Protocol

Y. Guéguen , L. Roy , S. Hornhardt , C. Badie , Janet Hall et al.
Radiation Research, 2017, 187 (1), pp.107-127. ⟨10.1667/RR14505.1⟩
Article dans une revue hal-02546109 v1

Ionizing radiation biomarkers in epidemiological studies – An update

Janet Hall , Penny Jeggo , Catharine West , Maria Gomolka , Roel Quintens et al.
Mutation Research/Reviews in Mutation Research, 2017, 771, pp.59 - 84. ⟨10.1016/j.mrrev.2017.01.001⟩
Article dans une revue hal-01691623 v1

Concerted Uranium Research in Europe (CURE): Toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure

E. Cardis , J. Hall , L. Tomasek , S. Ancelet , C. Badie et al.
Journal of Radiological Protection, 2016, 36 (2), pp.319-345. ⟨10.1088/0952-4746/36/2/319⟩
Article dans une revue hal-03121953 v1

Chronic uranium contamination alters spinal motor neuron integrity via modulation of SMN1 expression and microglia recruitment

B. Saint-Marc , C. Elie , L. Manens , K. Tack , M. Benderitter et al.
Toxicology Letters, 2016, 254, pp.37-44. ⟨10.1016/j.toxlet.2016.05.004⟩
Article dans une revue hal-02558441 v1

Environmentally Relevant Chronic Low-Dose Tritium and Gamma Exposures do not Increase Somatic Intrachromosomal Recombination in pKZ1 Mouse Spleen

L. Bannister , M. Serran , L. Bertrand , D. Klokov , H. Wyatt et al.
Radiation Research, 2016, 186 (6), pp.539-548. ⟨10.1667/RR14564.1⟩
Article dans une revue hal-02559804 v1
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Chronic exposure of adult, postnatal and in utero rat models to low-dose 137Cesium Impact on circulating biomarkers

Line Manens , S. Grison , Jean-Marc Bertho , P. Lestaevel , Y. Guéguen et al.
Journal of Radiation Research, 2016, 57 (6), pp.607-619. ⟨10.1093/jrr/rrw067⟩
Article dans une revue hal-02559819 v1
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Chronic internal exposure to low dose 137Cs induces positive impact on the stability of atherosclerotic plaques by reducing inflammation in ApoE-/- mice

C. Le Gallic , Y. Phalente , Line Manens , I. Dublineau , M. Benderitter et al.
PLoS ONE, 2015, 10 (6), pp.e0128539. ⟨10.1371/journal.pone.0128539⟩
Article dans une revue hal-02570493 v1

Low-concentration uranium enters the HepG2 cell nucleus rapidly and induces cell stress response

Y. Guéguen , D. Suhard , C. Poisson , L. Manens , C. Elie et al.
Toxicology in Vitro, 2015, 30 (1), pp.552-560. ⟨10.1016/j.tiv.2015.09.004⟩
Article dans une revue hal-02572593 v1

Molecular, cellular, and tissue impact of depleted uranium on xenobiotic-metabolizing enzymes

Y. Gueguen , C. Rouas , A. Monin , L. Manens , J. Stefani et al.
Archives of Toxicology, 2014, 88 (2), pp.227-239. ⟨10.1007/s00204-013-1145-y⟩
Article dans une revue hal-02611857 v1

Chronic uranium exposure dose-dependently induces glutathione in rats without any nephrotoxicity

C. Poisson , J. Stefani , L. Manens , O. Delissen , D. Suhard et al.
Free Radical Research, 2014, 48 (10), pp.1218-1231. ⟨10.3109/10715762.2014.945441⟩
Article dans une revue hal-02641776 v1

Antioxidant status in rat kidneys after coexposure to uranium and gentamicin

C. Poisson , C. Rouas , L. Manens , I. Dublineau , Y. Gueguen
Human and Experimental Toxicology, 2014, 33 (2), pp.136-147. ⟨10.1177/0960327113493297⟩
Article dans une revue hal-02611876 v1
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Unexpected lack of deleterious effects of uranium on physiological systems following a chronic oral intake in adult rat

I. Dublineau , M. Souidi , Y. Gueguen , P. Lestaevel , Jean-Marc Bertho et al.
BioMed Research International , 2013, 2014, pp.81989. ⟨10.1155/2014/181989⟩
Article dans une revue hal-03118948 v1

Les biomarqueurs d'atteinte rénale

Y. Gueguen , C. Rouas , F.A. Leblond
Néphrologie & Thérapeutique, 2012, 8 (3), pp.146-155. ⟨10.1016/j.nephro.2012.02.004⟩
Article dans une revue istex hal-02909504 v1

New data on uranium nephrotoxicity [Données nouvelles sur la néphrotoxicité de l'uranium]

Y. Gueguen , C. Rouas
Radioprotection, 2012, 47 (3), pp.345-359. ⟨10.1051/radiopro/2012015⟩
Article dans une revue hal-02909489 v1

Effect of nephrotoxic treatment with gentamicin on rats chronically exposed to uranium

C. Rouas , J. Stefani , S. Grison , L. Grandcolas , C. Baudelin et al.
Toxicology, 2011, 279, pp.27--35. ⟨10.1016/j.tox.2010.09.003⟩
Article dans une revue istex hal-02924836 v1

Distribution of soluble uranium in the nuclear cell compartment at subtoxic concentrations.

Caroline Rouas , Hélène Bensoussan , David Suhard , Christine Tessier , Line Grandcolas et al.
Chemical Research in Toxicology, 2010, 23 (12), pp.1883-9. ⟨10.1021/tx100168c⟩
Article dans une revue hal-01182983 v1

Césium 137 : Propriétés et effets biologiques après contamination interne

P. Lestaevel , R. Racine , H. Bensoussan , C. Rouas , Y. Gueguen et al.
Medecine Nucleaire, 2010, 34 (2), pp.108-118. ⟨10.1016/j.mednuc.2009.12.003⟩
Article dans une revue istex hal-02972618 v1
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Testicular steroidogenesis is not altered by 137 cesium Chernobyl fallout, following in utero or post-natal chronic exposure

E. Grignard , Y. Guéguen , S. Grison , I. Dublineau , P. Gourmelon et al.
Comptes Rendus. Biologies, 2010, 333 (5), pp.416-423. ⟨10.1016/j.crvi.2010.02.003⟩
Article dans une revue hal-02974277 v1

Vitamin D metabolism impairment in the rat's offspring following maternal exposure to 137cesium

E. Tissandie , Y. Guéguen , J.M.A. Lobaccaro , L. Grandcolas , S. Grison et al.
Archives of Toxicology, 2009, 83 (4), pp.357-362. ⟨10.1007/s00204-008-0351-5⟩
Article dans une revue istex hal-02985057 v1

Uranium: Propriétés et effets biologiques après contamination interne

M. Souidi , E. Tissandie , R. Racine , H. Ben Soussan , C. Rouas et al.
Annales de Biologie Clinique, 2009, 67 (1), pp.23-38. ⟨10.1684/abc.2008.0290⟩
Article dans une revue hal-02985073 v1

Acetaminophen induces xenobiotic-metabolizing enzymes in rat: Impact of a uranium chronic exposure

C. Rouas , M. Souidi , L. Grandcolas , S. Grison , C. Baudelin et al.
Environmental Toxicology and Pharmacology, 2009, 28 (3), pp.363-369. ⟨10.1016/j.etap.2009.06.004⟩
Article dans une revue istex hal-02993478 v1

Modifications of the expression of genes involved in cerebral cholesterol metabolism in the rat following chronic ingestion of depleted uranium

R. Racine , Y. Guéguen , P. Gourmelon , G. Veyssière , M. Souidi
Journal of Molecular Neuroscience, 2009, 38 (2), pp.159-165. ⟨10.1007/s12031-008-9145-8⟩
Article dans une revue istex hal-02988593 v1

Molecular modifications of cholesterol metabolism in the liver and the brain after chronic contamination with cesium 137

R. Racine , L. Grandcolas , S. Grison , P. Gourmelon , Y. Guéguen et al.
Food and Chemical Toxicology, 2009, 47 (7), pp.1642-1647. ⟨10.1016/j.fct.2009.04.022⟩
Article dans une revue hal-02988582 v1

Enriched uranium affects the expression of vitamin D receptor and retinoid X receptor in rat kidney

E. Tissandie , Y. Guéguen , J.M.A. Lobaccaro , L. Grandcolas , J. Aigueperse et al.
Journal of Steroid Biochemistry and Molecular Biology, 2008, 110 (3-5), pp.263-268. ⟨10.1016/j.jsbmb.2007.11.002⟩
Article dans une revue istex hal-03002300 v1

Contamination with depleted or enriched uranium differently affects steroidogenesis metabolism in rat

E. Grignard , Y. Guéguen , S. Grison , J.-M.A. Lobaccaro , P. Gourmelon et al.
International Journal of Toxicology, 2008, 27 (4), pp.323-328. ⟨10.1080/10915810802367057⟩
Article dans une revue hal-03002291 v1

Chronic contamination of rats with 137cesium radionuclide: Impact on the cardiovascular system

Y. Guéguen , P. Lestaevel , L. Grandcolas , C. Baudelin , S. Grison et al.
Cardiovascular Toxicology, 2008, 8 (1), pp.33-40. ⟨10.1007/s12012-008-9013-3⟩
Article dans une revue hal-03001420 v1

New biological indicators to evaluate and monitor radiation-induced damage: An accident case report

J.M. Bertho , L. Roy , M. Souidi , M. Benderitter , Y. Guéguen et al.
Radiation Research, 2008, 169 (5), pp.543-550. ⟨10.1667/RR1259.1⟩
Article dans une revue hal-03002305 v1

Effets du cësium-137 sur des fonctions physiologiques majeures chez le rongeur

Y. Guéguen , P. Lestaevel , J.-R. Jourdain , J.-M. Bertho , P. Gourmelon et al.
Biofutur, 2008, 291, pp.38-42
Article dans une revue hal-03005065 v1

In vivo effects of chronic contamination with 137 cesium on testicular and adrenal steroidogenesis

E. Grignard , Y. Guéguen , S. Grison , J.-M.A. Lobaccaro , P. Gourmelon et al.
Archives of Toxicology, 2008, 82 (9), pp.583-589. ⟨10.1007/s00204-007-0268-4⟩
Article dans une revue istex hal-03005072 v1

In vivo effects of chronic contamination with depleted uranium on vitamin D3 metabolism in rat

E. Tissandie , Y. Guéguen , J.M.A. Lobaccaro , L. Grandcolas , P. Voisin et al.
Biochimica et Biophysica Acta (BBA) - General Subjects, 2007, 1770 (2), pp.266-272. ⟨10.1016/j.bbagen.2006.10.006⟩
Article dans une revue istex hal-03008524 v1
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Compared Effect of Immunosuppressive Drugs Cyclosporine A and Rapamycin on Cholesterol Homeostasis Key Enzymes CYP27A1 and HMG-CoA Reductase

Yann Gueguen , Luc Ferrari , Maamar Souidi , Anne-Marie Batt , Claude Lutton et al.
Basic and Clinical Pharmacology and Toxicology, 2007, 100 (6), pp.392-397. ⟨10.1111/j.1742-7843.2007.00066.x⟩
Article dans une revue hal-01999411 v1

Effect of acetaminophen administration to rats chronically exposed to depleted uranium

Y. Guéguen , L. Grandcolas , C. Baudelin , S. Grison , E. Tissandie et al.
Toxicology, 2007, 229 (1-2), pp.62-72. ⟨10.1016/j.tox.2006.10.006⟩
Article dans une revue istex hal-03008528 v1

Chronic contamination with 137Cesium affects Vitamin D3 metabolism in rats

E. Tissandie , Y. Guéguen , J.M.A. Lobaccaro , J. Aigueperse , P. Gourmelon et al.
Toxicology, 2006, 225 (1), pp.75-80. ⟨10.1016/j.tox.2006.05.006⟩
Article dans une revue istex hal-03019586 v1

Vitamine D: Métabolisme, régulation et maladies associées

E. Tissandie , Y. Guéguen , J.-M.A. Lobaccaro , J. Aigueperse , M. Souidi
Médecine/Sciences, 2006, 22 (12), pp.1095-1100. ⟨10.1051/medsci/200622121095⟩
Article dans une revue hal-03029115 v1

Effects of depleted uranium after short-term exposure on vitamin D metabolism in rat

E. Tissandie , Y. Guéguen , J.M.A. Lobaccaro , F. Paquet , J. Aigueperse et al.
Archives of Toxicology, 2006, 80 (8), pp.473-480. ⟨10.1007/s00204-006-0068-2⟩
Article dans une revue istex hal-03019585 v1

Cytochromes P450: Xenobiotic metabolism, regulation and clinical importance

Y. Guéguen , K. Mouzat , L. Ferrari , E. Tissandie , J.M.A. Lobaccaro et al.
Annales de Biologie Clinique, 2006, 64 (6), pp.535-548. ⟨10.1684/abc.2006.0015⟩
Article dans une revue hal-03029085 v1

Chronic contamination with 137cesium in rat: Effect on liver cholesterol metabolism

M. Souidi , E. Tissandie , L. Grandcolas , S. Grison , F. Paquet et al.
International Journal of Toxicology, 2006, 25 (6), pp.493-497. ⟨10.1080/10915810600961317⟩
Article dans une revue hal-03029105 v1

Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat.

Y. Guéguen , M. Souidi , C. Baudelin , N. Dudoignon , S. Grison et al.
Archiv für Toxikologie, 2006, 80 (4), pp.187-95. ⟨10.1007/s00204-005-0027-3⟩
Article dans une revue istex hal-00405239 v1

In vivo effects of chronic contamination with depleted uranium on CYP3A and associated nuclear receptors PXR and CAR in the rat.

M. Souidi , Yann Gueguen , C. Linard , N. Dudoignon , S. Grison et al.
Toxicology, 2005, 214 (1-2), pp.113-22. ⟨10.1016/j.tox.2005.06.006⟩
Article dans une revue istex hal-00405243 v1
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Mécanismes de l'hyperlipidémie provoquée par les immunosuppresseurs

Yann Gueguen
Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2003. Français. ⟨NNT : 2003NAN10250⟩
Thèse tel-01746939 v1