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Yann GUEGUEN

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Publications

Renal toxicity and biokinetics models after repeated uranium instillation

Chrystelle Ibanez , Laurie de Castro , Annabelle Manoury , Bastien Simoneau , Christelle Elie
56th Congress European Societies of Toxicology, EUROTOX Congress 2021, du 27/09/2021 au 01/10/2021,, Sep 2021, VIRTUAL, Denmark. pp.S194, ⟨10.1016/S0378-4274(21)00697-4⟩
Communication dans un congrès hal-03716880v1

Renal toxicity and biokinetics models after repeated uranium instillation

Laurence Roy , Estelle Davesne , Bastien Simoneau , Annabelle Manoury , Christelle Elie
15th International Congress ofthe International Radiation Protection Association, IRPA - International Radiation Protection Association; KARP - Korean Association for Radiation Protection, Jan 2021, Seoul, South Korea
Communication dans un congrès hal-04100195v1
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In vivo comparison between two nephrotoxic agents, sodium fluoride and uranyl nitrate: phenotypic aspects and molecular mechanisms involved

Alice Bontemps , Laurine Conquet , Christelle Elie , Victor Magneron , Celine Gloaguen
International Conference on the Health Effects of Incorporated Radionuclides, HEIR, Oct 2019, FONTENAY-AUX-ROSES, France. pp.05004, ⟨10.1051/bioconf/20191405004⟩
Communication dans un congrès hal-02635732v1

Studying biomarkers reflecting the adverse outcome pathways from exposures to diseases using molecular epidemiology: example of the molecular epidemiology protocol developed as part of the Concerted Uranium Research in Europe (CURE) project

Maria Gomolka , Olivier Laurent , Laurence Roy , Sabine Hornhardt , Christophe Badie
Eurpean Radiation Protection Week, ERPW 2019, Oct 2019, STOCKHOLM, Sweden
Communication dans un congrès hal-03150525v1

Toxicologie predictive: les voies du futur

Ph Detilleux , L Vallier , C Legallais , E Leclerc , M Prot J
Congrès de la SPTC - Société de Pharmaco-Toxicologie Cellulaire, May 2010, Paris, France
Communication dans un congrès hal-01122677v1
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Renal toxicity and biokinetics models after repeated uranium instillation

Laurie de Castro , Annabelle Manoury , Olivier Claude , Bastien Simoneau , V. Monceau
Scientific Reports, 2023, 13 (1), pp.4111. ⟨10.1038/s41598-023-31073-1⟩
Article dans une revue irsn-04032713v1
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Review of Knowledge of Uranium-Induced Kidney Toxicity for the Development of an Adverse Outcome Pathway to Renal Impairment

Yann Guéguen , Marie Frerejacques
International Journal of Molecular Sciences, 2022, 23 (8), pp.4397. ⟨10.3390/ijms23084397⟩
Article dans une revue irsn-03959341v1
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Renal adaptive response to exposure to low doses of uranyl nitrate and sodium fluoride in mice

Alice Bontemps , Victor Magneron , Laurine Conquet , Christelle Elie , Celine Gloaguen
Journal of Trace Elements in Medicine and Biology, 2021, 64, pp.126708. ⟨10.1016/j.jtemb.2020.126708⟩
Article dans une revue hal-03471501v1
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Adaptive responses to low doses of radiation or chemicals their cellular and molecular mechanisms

Y. Guéguen , A. Bontemps , T.G. Ebrahimian
Cellular and Molecular Life Sciences, 2019, 76 (7), pp.1255-1273. ⟨10.1007/s00018-018-2987-5⟩
Article dans une revue hal-02524214v1
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In vivo comparison of the phenotypic aspects and molecular mechanisms of two nephrotoxic agents, sodium fluoride and uranyl nitrate

A. Bontemps , L. Conquet , C. Elie , V. Magneron , C. Gloaguen
International Journal of Environmental Research and Public Health, 2019, 16 (7), pp.1136. ⟨10.3390/ijerph16071136⟩
Article dans une revue hal-02524211v1
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Chronic Exposure to External Low-Dose Gamma Radiation Induces an Increase in Anti-inflammatory and Anti-oxidative Parameters Resulting in Atherosclerotic Plaque Size Reduction in ApoE–/– Mice

Teni Ebrahimian Chiusa , Louison Beugnies , Joel Surette , Nick Priest , Yann Gueguen
Radiation Research, 2018, 189 (2), pp.187-196. ⟨10.1667/RR14823.1⟩
Article dans une revue hal-02457222v1

Intracellular uranium distribution : Comparison of cryogenic fixation versus chemical fixation methods for SIMS analysis

D. Suhard , C. Tessier , L. Manens , F. Rebière , K. Tack
Microscopy Research and Technique, 2018, 81 (8), pp.855-864. ⟨10.1002/jemt.23047⟩
Article dans une revue hal-02874521v1

In vivo animal studies help achieve international consensus on standards and guidelines for health risk estimates for chronic exposure to low levels of tritium in drinking water

Y. Guéguen , N.D. Priest , I. Dublineau , L. Bannister , M. Benderitter
Environmental and Molecular Mutagenesis, 2018, 59 (7), pp.586-594. ⟨10.1002/em.22200⟩
Article dans une revue hal-02874507v1

Biomarkers for Uranium Risk Assessment for the Development of the CURE (Concerted Uranium Research in Europe) Molecular Epidemiological Protocol

Y. Guéguen , L. Roy , S. Hornhardt , C. Badie , Janet Hall
Radiation Research, 2017, 187 (1), pp.107-127. ⟨10.1667/RR14505.1⟩
Article dans une revue hal-02546109v1

Ionizing radiation biomarkers in epidemiological studies – An update

Janet Hall , Penny Jeggo , Catharine West , Maria Gomolka , Roel Quintens
Mutation Research/Reviews in Mutation Research, 2017, 771, pp.59 - 84. ⟨10.1016/j.mrrev.2017.01.001⟩
Article dans une revue hal-01691623v1

Chronic exposure of adult, postnatal and in utero rat models to low-dose 137Cesium Impact on circulating biomarkers

L. Manens , S. Grison , J.-M. Bertho , P. Lestaevel , Y. Guéguen
Journal of Radiation Research, 2016, 57 (6), pp.607-619. ⟨10.1093/jrr/rrw067⟩
Article dans une revue hal-02559819v1

Concerted Uranium Research in Europe (CURE): Toward a collaborative project integrating dosimetry, epidemiology and radiobiology to study the effects of occupational uranium exposure

E. Cardis , J. Hall , L. Tomasek , S. Ancelet , C. Badie
Journal of Radiological Protection, 2016, 36 (2), pp.319-345. ⟨10.1088/0952-4746/36/2/319⟩
Article dans une revue hal-03121953v1

Chronic uranium contamination alters spinal motor neuron integrity via modulation of SMN1 expression and microglia recruitment

B. Saint-Marc , C. Elie , L. Manens , K. Tack , M. Benderitter
Toxicology Letters, 2016, 254, pp.37-44. ⟨10.1016/j.toxlet.2016.05.004⟩
Article dans une revue hal-02558441v1

Environmentally Relevant Chronic Low-Dose Tritium and Gamma Exposures do not Increase Somatic Intrachromosomal Recombination in pKZ1 Mouse Spleen

L. Bannister , M. Serran , L. Bertrand , D. Klokov , H. Wyatt
Radiation Research, 2016, 186 (6), pp.539-548. ⟨10.1667/RR14564.1⟩
Article dans une revue hal-02559804v1

Low-concentration uranium enters the HepG2 cell nucleus rapidly and induces cell stress response

Y. Guéguen , D. Suhard , C. Poisson , L. Manens , C. Elie
Toxicology in Vitro, 2015, 30 (1), pp.552-560. ⟨10.1016/j.tiv.2015.09.004⟩
Article dans une revue hal-02572593v1

Chronic internal exposure to low dose 137Cs induces positive impact on the stability of atherosclerotic plaques by reducing inflammation in ApoE-/- mice

C. Le Gallic , Y. Phalente , L. Manens , I. Dublineau , M. Benderitter
PLoS ONE, 2015, 10 (6), pp.e0128539. ⟨10.1371/journal.pone.0128539⟩
Article dans une revue hal-02570493v1

Chronic uranium exposure dose-dependently induces glutathione in rats without any nephrotoxicity

C. Poisson , J. Stefani , L. Manens , O. Delissen , D. Suhard
Free Radical Research, 2014, 48 (10), pp.1218-1231. ⟨10.3109/10715762.2014.945441⟩
Article dans une revue hal-02641776v1

Molecular, cellular, and tissue impact of depleted uranium on xenobiotic-metabolizing enzymes

Y. Gueguen , C. Rouas , A. Monin , L. Manens , J. Stefani
Archives of Toxicology, 2014, 88 (2), pp.227-239. ⟨10.1007/s00204-013-1145-y⟩
Article dans une revue hal-02611857v1

Antioxidant status in rat kidneys after coexposure to uranium and gentamicin

C. Poisson , C. Rouas , L. Manens , I. Dublineau , Y. Gueguen
Human and Experimental Toxicology, 2014, 33 (2), pp.136-147. ⟨10.1177/0960327113493297⟩
Article dans une revue hal-02611876v1

Unexpected lack of deleterious effects of uranium on physiological systems following a chronic oral intake in adult rat

I. Dublineau , M. Souidi , Y. Gueguen , P. Lestaevel , J.-M. Bertho
BioMed Research International , 2014, 2014, ⟨10.1155/2014/181989⟩
Article dans une revue hal-03118948v1

New data on uranium nephrotoxicity [Données nouvelles sur la néphrotoxicité de l'uranium]

Y. Gueguen , C. Rouas
Radioprotection, 2012, 47 (3), pp.345-359. ⟨10.1051/radiopro/2012015⟩
Article dans une revue hal-02909489v1

Les biomarqueurs d'atteinte rénale

Y. Gueguen , C. Rouas , F.A. Leblond
Néphrologie & Thérapeutique, 2012, 8 (3), pp.146-155. ⟨10.1016/j.nephro.2012.02.004⟩
Article dans une revue hal-02909504v1

Effect of nephrotoxic treatment with gentamicin on rats chronically exposed to uranium

C. Rouas , J. Stefani , S. Grison , L. Grandcolas , C. Baudelin
Toxicology, 2011, 279, pp.27--35. ⟨10.1016/j.tox.2010.09.003⟩
Article dans une revue hal-02924836v1

Testicular steroidogenesis is not altered by 137 cesium Chernobyl fallout, following in utero or post-natal chronic exposure

E. Grignard , Y. Guéguen , S. Grison , I. Dublineau , P. Gourmelon
Comptes Rendus Biologies, 2010, 333 (5), pp.416-423. ⟨10.1016/j.crvi.2010.02.003⟩
Article dans une revue hal-02974277v1

Distribution of soluble uranium in the nuclear cell compartment at subtoxic concentrations.

Caroline Rouas , Hélène Bensoussan , David Suhard , Christine Tessier , Line Grandcolas
Chemical Research in Toxicology, 2010, 23 (12), pp.1883-9. ⟨10.1021/tx100168c⟩
Article dans une revue hal-01182983v1

Césium 137 : Propriétés et effets biologiques après contamination interne

P. Lestaevel , R. Racine , H. Bensoussan , C. Rouas , Y. Gueguen
Medecine Nucleaire, 2010, 34 (2), pp.108-118. ⟨10.1016/j.mednuc.2009.12.003⟩
Article dans une revue hal-02972618v1

Vitamin D metabolism impairment in the rat's offspring following maternal exposure to 137cesium

E. Tissandie , Y. Guéguen , J.M.A. Lobaccaro , L. Grandcolas , S. Grison
Archives of Toxicology, 2009, 83 (4), pp.357-362. ⟨10.1007/s00204-008-0351-5⟩
Article dans une revue hal-02985057v1

Molecular modifications of cholesterol metabolism in the liver and the brain after chronic contamination with cesium 137

R. Racine , L. Grandcolas , S. Grison , P. Gourmelon , Y. Guéguen
Food and Chemical Toxicology, 2009, 47 (7), pp.1642-1647. ⟨10.1016/j.fct.2009.04.022⟩
Article dans une revue hal-02988582v1

Modifications of the expression of genes involved in cerebral cholesterol metabolism in the rat following chronic ingestion of depleted uranium

R. Racine , Y. Guéguen , P. Gourmelon , G. Veyssière , M. Souidi
Journal of Molecular Neuroscience, 2009, 38 (2), pp.159-165. ⟨10.1007/s12031-008-9145-8⟩
Article dans une revue hal-02988593v1

Acetaminophen induces xenobiotic-metabolizing enzymes in rat: Impact of a uranium chronic exposure

C. Rouas , M. Souidi , L. Grandcolas , S. Grison , C. Baudelin
Environmental Toxicology and Pharmacology, 2009, 28 (3), pp.363-369. ⟨10.1016/j.etap.2009.06.004⟩
Article dans une revue hal-02993478v1

Uranium: Propriétés et effets biologiques après contamination interne

M. Souidi , E. Tissandie , R. Racine , H. Ben Soussan , C. Rouas
Annales de Biologie Clinique, 2009, 67 (1), pp.23-38. ⟨10.1684/abc.2008.0290⟩
Article dans une revue hal-02985073v1

New biological indicators to evaluate and monitor radiation-induced damage: An accident case report

J.M. Bertho , L. Roy , M. Souidi , M. Benderitter , Y. Guéguen
Radiation Research, 2008, 169 (5), pp.543-550. ⟨10.1667/RR1259.1⟩
Article dans une revue hal-03002305v1

Chronic contamination of rats with 137cesium radionuclide: Impact on the cardiovascular system

Y. Guéguen , P. Lestaevel , L. Grandcolas , C. Baudelin , S. Grison
Cardiovascular Toxicology, 2008, 8 (1), pp.33-40. ⟨10.1007/s12012-008-9013-3⟩
Article dans une revue hal-03001420v1

Contamination with depleted or enriched uranium differently affects steroidogenesis metabolism in rat

E. Grignard , Y. Guéguen , S. Grison , J.-M.A. Lobaccaro , P. Gourmelon
International Journal of Toxicology, 2008, 27 (4), pp.323-328. ⟨10.1080/10915810802367057⟩
Article dans une revue hal-03002291v1

Enriched uranium affects the expression of vitamin D receptor and retinoid X receptor in rat kidney

E. Tissandie , Y. Guéguen , J.M.A. Lobaccaro , L. Grandcolas , J. Aigueperse
Journal of Steroid Biochemistry and Molecular Biology, 2008, 110 (3-5), pp.263-268. ⟨10.1016/j.jsbmb.2007.11.002⟩
Article dans une revue hal-03002300v1

In vivo effects of chronic contamination with 137 cesium on testicular and adrenal steroidogenesis

E. Grignard , Y. Guéguen , S. Grison , J.-M.A. Lobaccaro , P. Gourmelon
Archives of Toxicology, 2008, 82 (9), pp.583-589. ⟨10.1007/s00204-007-0268-4⟩
Article dans une revue hal-03005072v1

Effets du cësium-137 sur des fonctions physiologiques majeures chez le rongeur

Y. Guéguen , P. Lestaevel , J.-R. Jourdain , J.-M. Bertho , P. Gourmelon
Biofutur, 2008, 291, pp.38-42
Article dans une revue hal-03005065v1

Effect of acetaminophen administration to rats chronically exposed to depleted uranium

Y. Guéguen , L. Grandcolas , C. Baudelin , S. Grison , E. Tissandie
Toxicology, 2007, 229 (1-2), pp.62-72. ⟨10.1016/j.tox.2006.10.006⟩
Article dans une revue hal-03008528v1

In vivo effects of chronic contamination with depleted uranium on vitamin D3 metabolism in rat

E. Tissandie , Y. Guéguen , J.M.A. Lobaccaro , L. Grandcolas , P. Voisin
Biochimica et Biophysica Acta (BBA) - General Subjects, 2007, 1770 (2), pp.266-272. ⟨10.1016/j.bbagen.2006.10.006⟩
Article dans une revue hal-03008524v1
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Compared Effect of Immunosuppressive Drugs Cyclosporine A and Rapamycin on Cholesterol Homeostasis Key Enzymes CYP27A1 and HMG-CoA Reductase

Yann Gueguen , Luc Ferrari , Maamar Souidi , Anne-Marie Batt , Claude Lutton
Basic and Clinical Pharmacology and Toxicology, 2007, 100 (6), pp.392-397. ⟨10.1111/j.1742-7843.2007.00066.x⟩
Article dans une revue hal-01999411v1

Chronic contamination with 137Cesium affects Vitamin D3 metabolism in rats

E. Tissandie , Y. Guéguen , J.M.A. Lobaccaro , J. Aigueperse , P. Gourmelon
Toxicology, 2006, 225 (1), pp.75-80. ⟨10.1016/j.tox.2006.05.006⟩
Article dans une revue hal-03019586v1

Cytochromes P450: Xenobiotic metabolism, regulation and clinical importance

Y. Guéguen , K. Mouzat , L. Ferrari , E. Tissandie , J.M.A. Lobaccaro
Annales de Biologie Clinique, 2006, 64 (6), pp.535-548. ⟨10.1684/abc.2006.0015⟩
Article dans une revue hal-03029085v1

Chronic contamination with 137cesium in rat: Effect on liver cholesterol metabolism

M. Souidi , E. Tissandie , L. Grandcolas , S. Grison , F. Paquet
International Journal of Toxicology, 2006, 25 (6), pp.493-497. ⟨10.1080/10915810600961317⟩
Article dans une revue hal-03029105v1

Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat.

Y. Guéguen , M. Souidi , C. Baudelin , N. Dudoignon , S. Grison
Archiv für Toxikologie, 2006, 80 (4), pp.187-95. ⟨10.1007/s00204-005-0027-3⟩
Article dans une revue hal-00405239v1

Effects of depleted uranium after short-term exposure on vitamin D metabolism in rat

E. Tissandie , Y. Guéguen , J.M.A. Lobaccaro , F. Paquet , J. Aigueperse
Archives of Toxicology, 2006, 80 (8), pp.473-480. ⟨10.1007/s00204-006-0068-2⟩
Article dans une revue hal-03019585v1

Vitamine D: Métabolisme, régulation et maladies associées

E. Tissandie , Y. Guéguen , J.-M.A. Lobaccaro , J. Aigueperse , M. Souidi
Médecine/Sciences, 2006, 22 (12), pp.1095-1100. ⟨10.1051/medsci/200622121095⟩
Article dans une revue hal-03029115v1

In vivo effects of chronic contamination with depleted uranium on CYP3A and associated nuclear receptors PXR and CAR in the rat.

M. Souidi , Yann Gueguen , C. Linard , N. Dudoignon , S. Grison
Toxicology, 2005, 214 (1-2), pp.113-22. ⟨10.1016/j.tox.2005.06.006⟩
Article dans une revue hal-00405243v1
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Mécanismes de l'hyperlipidémie provoquée par les immunosuppresseurs

Yann Gueguen
Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2003. Français. ⟨NNT : 2003NAN10250⟩
Thèse tel-01746939v1