Yuna Blum

61
Documents

Publications

Publications

Image document

Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom‐up approach

Marc Hilmi , Flore Delecourt , Jérôme Raffenne , Taib Bourega , Nelson Dusetti et al.
Journal of Pathology, 2025, 265 (4), pp.448-461. ⟨10.1002/path.6398⟩
Article dans une revue hal-04980252 v1
Image document

Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3Kα-dependent hepatocyte signaling

Marion Régnier , Arnaud Polizzi , Tiffany Fougeray , Anne Fougerat , Prunelle Perrier et al.
PLoS Biology, 2025, 23 (4), pp.e3003112-e3003112. ⟨10.1371/journal.pbio.3003112⟩
Article dans une revue hal-05063626 v1
Image document

Cirscan: a shiny application to identify differentially active sponge mechanisms and visualize circRNA-miRNA-mRNA networks

Rose-Marie Fraboulet , Yanis Si Ahmed , Marc Aubry , Sébastien Corre , Marie-Dominique Galibert et al.
BMC Bioinformatics, 2024, 25 (1), pp.53. ⟨10.1186/s12859-024-05668-y⟩
Article dans une revue hal-04540383 v1
Image document

DECOMICS, a shiny application for unsupervised cell type deconvolution and biological interpretation of bulk omic data

Slim Karkar , Ashwini Sharma , Carl Herrmann , Yuna Blum , Magali Richard
Bioinformatics Advances, 2024, 4 (1), pp.vbae136. ⟨10.1093/bioadv/vbae136⟩
Article dans une revue hal-04660629 v2
Image document

Preclinical evaluation of CDK4 phosphorylation predicts high sensitivity of pleural mesotheliomas to CDK4/6 inhibition

Sabine Paternot , Eric Raspé , C Meiller , Maxime Tarabichi , Jean-Baptiste Assié et al.
Molecular Oncology, 2024, 18 (4), pp.866-894. ⟨10.1002/1878-0261.13351⟩
Article dans une revue hal-03898858 v1
Image document

Priming therapy by targeting enhancer-initiated pathways in patient-derived pancreatic cancer cells

Nicolas A Fraunhoffer , Aura I Moreno Vega , Analía Meilerman Abuelafia , Marie Morvan , Emilie Lebarbier et al.
EBioMedicine, 2023, 92, pp.104602. ⟨10.1016/j.ebiom.2023.104602⟩
Article dans une revue hal-04100206 v1
Image document

Ephrin-B1 regulates the adult diastolic function through a late postnatal maturation of cardiomyocyte surface crests

Clement Karsenty , Celine Guilbeau-Frugier , Gaël Genet , Marie-Helene Seguelas , Philippe Alzieu et al.
eLife, 2023, 12, pp.e80904. ⟨10.7554/eLife.80904⟩
Article dans une revue hal-03944430 v1
Image document

Pacpaint: a histology-based deep learning model uncovers the extensive intratumor molecular heterogeneity of pancreatic adenocarcinoma

Charlie Saillard , Flore Delecourt , Benoit Schmauch , Olivier Moindrot , Magali Svrcek et al.
Nature Communications, 2023, 14 (1), pp.3459. ⟨10.1038/s41467-023-39026-y⟩
Article dans une revue hal-04164254 v1
Image document

Genomic Instability and Pro-Tumoral Inflammation are associated with Primary Resistance to Anti-PD1 + Anti-Angiogenesis in Malignant Pleural Mesothelioma

Francois-Xavier Danlos , Matthieu Texier , Bastien Job , Severine Mouraud , Lydie Cassard et al.
Cancer Discovery, 2023, 13 (4), pp.858-879. ⟨10.1158/2159-8290.CD-22-0886⟩
Article dans une revue hal-03972355 v1
Image document

Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target

Sarra Smati , Arnaud Polizzi , Anne Fougerat , Sandrine Ellero-Simatos , Yuna Blum et al.
Gut, 2022, 71 (4), pp.807-821. ⟨10.1136/gutjnl-2020-323323⟩
Article dans une revue hal-03215969 v1
Image document

Multi-site tumor sampling highlights molecular intra-tumor heterogeneity in malignant pleural mesothelioma

Clément Meiller , François Montagne , Theo Hirsch , Stefano Caruso , Julien de Wolf et al.
Genome Medicine, 2021, 13 (1), pp.113. ⟨10.1186/s13073-021-00931-w⟩
Article dans une revue inserm-03289952 v1
Image document

Intratumor CMS Heterogeneity Impacts Patient Prognosis in Localized Colon Cancer

Laetitia Marisa , Yuna Blum , Julien Taieb , Mira Ayadi , Camilla Pilati et al.
Clinical Cancer Research, 2021, 27 (17), pp.4768-4780. ⟨10.1158/1078-0432.CCR-21-0529⟩
Article dans une revue hal-03282346 v1
Image document

DECONbench: a benchmarking platform dedicated to deconvolution methods for tumor heterogeneity quantification

Clémentine Decamps , Alexis Arnaud , Florent Petitprez , Mira Ayadi , Aurélia Baurès et al.
BMC Bioinformatics, 2021, 22 (1), pp.473. ⟨10.1186/s12859-021-04381-4⟩
Article dans une revue hal-03372668 v1
Image document

Depicting the genetic architecture of pediatric cancers through an integrative gene network approach

Clara Savary , Artem Kim , Alexandra Lespagnol , Virginie Gandemer , Isabelle Pellier et al.
Scientific Reports, 2020, 10 (1), pp.1224. ⟨10.1038/s41598-020-58179-0⟩
Article dans une revue hal-02472258 v1
Image document

Genetic alterations of malignant pleural mesothelioma: association to tumor heterogeneity and overall survival Author names

Lisa Quetel , Clément Meiller , Jean-Baptiste Assié , Yuna Blum , Sandrine Imbeaud et al.
Molecular Oncology, 2020, Epub ahead of print. ⟨10.1002/1878‐0261.12651⟩
Article dans une revue inserm-02490591 v1

Deciphering the Genetic Etiology of Pediatric Cancers Through an Integrative Gene Network Approach

C. Savary , A. Kim , A. Lespagnol , V. Gandemer , I. Pellier et al.
Pediatric Blood and Cancer, 2019, 66, pp.S509-S509
Article dans une revue hal-02355731 v1
Image document

Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications

Yuna Blum , Clément Meiller , Lisa Quetel , Nabila Elarouci , Mira Ayadi et al.
Nature Communications, 2019, 10, pp.1333. ⟨10.1038/s41467-019-09307-6⟩
Article dans une revue hal-02090279 v1
Image document

Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

Gwen Lomberk , Yuna Blum , Remy Nicolle , Asha Nair , Krutika Satish Gaonkar et al.
Nature Communications, 2018, 9 (1), pp.1978. ⟨10.1038/s41467-018-04383-6⟩
Article dans une revue hal-02143535 v1

Stratification of Pancreatic Ductal Adenocarcinomas Based on Tumor and Microenvironment Features

Francesco Puleo , Remy Nicolle , Yuna Blum , Jerome Cros , Laetitia Marisa et al.
Gastroenterology, 2018, 155 (6), pp.1999+. ⟨10.1053/j.gastro.2018.08.033⟩
Article dans une revue hal-02143548 v1
Image document

Multi-tissue transcriptomic study reveals the main role of liver in the chicken adaptive response to a switch in dietary energy source through the transcriptional regulation of lipogenesis

Colette Désert , Elisabeth Baéza , Meziane Aite , Morgane Boutin , Aurélie Le Cam et al.
BMC Genomics, 2018, 19 (1), pp.1-19. ⟨10.1186/s12864-018-4520-5⟩
Article dans une revue hal-01727161 v1

Multi-omic approaches unveil new therapeutic targets for the treatment of pancreatic cancer

Remy Nicolle , Yuna Blum , Laetitia Marisa , Nelson Dusetti , Juan Iovanna
Médecine/Sciences, 2018, 34 (5), pp.379-382. ⟨10.1051/medsci/20183405003⟩
Article dans une revue hal-02143669 v1
Image document

Gene expression profiling of patient‐derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts

Benjamin Bian , Martin Bigonnet , Odile Gayet , Céline Loncle , Aurélie Maignan et al.
EMBO Molecular Medicine, 2017, 9 (4), pp.482 - 497. ⟨10.15252/emmm.201606975⟩
Article dans une revue hal-01787567 v1
Image document

Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts

Remy Nicolle , Yuna Blum , Laëtitia Marisa , Céline Loncle , Odile Gayet et al.
Cell Reports, 2017, 21 (9), pp.2458-2470. ⟨10.1016/j.celrep.2017.11.003⟩
Article dans une revue inserm-01985259 v1
Image document

Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function

Zahia Touat-Hamici , Henri Weidmann , Yuna Blum , Carole Proust , Hervé Durand et al.
Cardiovascular Research, 2016, 112 (3), pp.702 - 713. ⟨10.1093/cvr/cvw217⟩
Article dans une revue hal-01484581 v1
Image document

Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals

Alexandra Montagner , Agata Korecka , Arnaud Polizzi , Yannick Lippi , Yuna Blum et al.
Scientific Reports, 2016, 6 (1), pp.1-14. ⟨10.1038/srep20127⟩
Article dans une revue hal-01482816 v1

Sparse factor model for co-expression networks with an application using prior biological knowledge

Yuna Blum , Magalie Houée-Bigot , David Causeur
Statistical Applications in Genetics and Molecular Biology, 2016, 15 (3), pp.253-272. ⟨10.1515/sagmb-2015-0002⟩
Article dans une revue hal-01340542 v1
Image document

Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans

Veronica Codoni , Yuna Blum , Mete Civelek , Carole Proust , Oscar Franzén et al.
G3, 2016, 6 (10), pp.3361-3371. ⟨10.1534/g3.116.033894⟩
Article dans une revue hal-01404133 v1
Image document

Bariatric Surgery Induces Disruption in Inflammatory Signaling Pathways Mediated by Immune Cells in Adipose Tissue: A RNA-Seq Study

Christine Poitou , Claire Perret , François Mathieu , Vinh Truong , Yuna Blum et al.
PLoS ONE, 2015, 10 (5), pp.e0125718. ⟨10.1371/journal.pone.0125718⟩
Article dans une revue hal-01227880 v1

Pleiotropic effects of polymorphism of the gene diacylglycerol-O-transferase 1 (DGAT1) in the mammary gland tissue of dairy cows

Núria Mach , Yuna Blum , A. Bannink , David Causeur , M. Houee-Bigot et al.
Journal of Dairy Science, 2012, 95 (9), pp.4989-5000. ⟨10.3168/jds.2012-5348⟩
Article dans une revue hal-00841015 v1
Image document

Complex trait subtypes identification using transcriptome profiling reveals an interaction between two QTL affecting adiposity in chicken

Yuna Blum , Guillaume Le Mignon , David Causeur , Olivier Filangi , Colette Désert et al.
BMC Genomics, 2011, 12 (november), pp.8. ⟨10.1186/1471-2164-12-567⟩
Article dans une revue hal-00730144 v1
Image document

Apports de la génomique fonctionnelle à la cartographie fine de QTL

Guillaume Le Mignon , Yuna Blum , Olivier Demeure , Christian Diot , Elisabeth Le Bihan-Duval et al.
INRA Productions Animales, 2010, 23 (4), pp.343-358
Article dans une revue hal-00729443 v1
Image document

Inferring cellular heterogeneity with mixture models for DNA methylation rates

Hugo Barbot , David Causeur , Yuna Blum , Magali Richard
JdS, Jun 2025, Marseille, France
Communication dans un congrès hal-05065027 v1

Multi-omic statistical inference of cellular heterogeneity - IGDR SCAN 26/03/2025

Hugo Barbot , David Causeur , Yuna Blum , Magali Richard
IGDR SCAN, Mar 2025, Rennes (CHU), France
Communication dans un congrès hal-05065011 v1

Multi-omic statistical inference of cellular heterogeneity - JOBIM 2024

Hugo Barbot , David Causeur , Yuna Blum , Magali Richard
JOBIM 2024, Jun 2024, Toulouse, France
Communication dans un congrès hal-04664788 v1

Redefining phenotypic heterogeneity of pancreatic ductal adenocarcinoma: A bottom-up approach

Marc Hilmi , Flore Delecourt , Jerôme Rafenne , Taib Bourega , Nelson Dusetti et al.
AACR Special Conference in Cancer Research: Pancreatic Cancer; 2023 Sep 27-30; Boston, Massachusetts., Sep 2023, Boston, United States. pp.B064-B064, ⟨10.1158/1538-7445.panca2023-b064⟩
Communication dans un congrès hal-04456752 v1
Image document

Multi-omic statistical inference of cellular heterogeneity - JdS 2024

Hugo Barbot , David Causeur , Yuna Blum , Magali Richard
JdS 2024, May 2024, Bordeaux, France
Communication dans un congrès hal-04664748 v1
Image document

Cirscan: a shiny application to identify differentially active sponge mechanisms and visualize circRNA-miRNA-mRNA networks

Rose-Marie Fraboulet , Yanis Si Ahmed , Marc Aubry , Sébastien Corre , Marie-Dominique Galibert et al.
JOURNÉES OUVERTES EN BIOLOGIE, INFORMATIQUE ET MATHÉMATIQUES (JOBIM ) 2023, Jun 2023, Diverses villes françaises, France
Communication dans un congrès hal-04286509 v1

PACpAInt: a deep learning approach to identify molecular subtypes of pancreatic adenocarcinoma on histology slides

C. Saillard , F. Delecourt , B. Schmauch , O. Moindrot , M. Svrcek et al.
Annual Meeting of the American-Association-for-Cancer-Research (AACR), Apr 2022, New Orleans, United States. pp.Abstract nr 472
Communication dans un congrès hal-04090168 v1
Image document

Identification of candidate polymorphism in a QTL region by combining eQTL mapping with NGS data

Pierre-François Roux , Yuna Blum , Colette Désert , Anis Djari , Diane Esquerre et al.
64th Annual Meeting of the European Federation of Animal Science (EAAP), Aug 2013, Nantes, France. pp.300
Communication dans un congrès hal-01019609 v1

Inférence de réseaux de co-expression génique

Yuna Blum , M. Houée , David Causeur
10ème Journée Biogenouest, Nov 2012, Rennes (FR), France. non paginé
Communication dans un congrès hal-00841018 v1

Genetic analysis of a complex trait using transcriptomic data: contribution of gene regulatory network modeling

Yuna Blum , Magalie Houée , Chloé Friguet , Sandrine Lagarrigue , David Causeur
XX. Conference of the plant & animal genome (PAG), Jan 2012, San Diego, United States. 1 p
Communication dans un congrès hal-00841103 v1
Image document

Transcriptome profiling reveals interaction between two QTL for fatness in chicken

Yuna Blum , Guillaume Le Mignon , Frederique Pitel , David Causeur , Olivier Demeure et al.
15th European workshop on QTL mapping and marker assisted selection (QTLMAS), May 2011, Rennes (FR), France. 1 p
Communication dans un congrès hal-00841016 v1
Image document

Inferring gene networks using a sparse factor model approach, Statistical Learning and Data Science

Yuna Blum , Magali Houée , Chloé Friguet , Sandrine Lagarrigue , David Causeur
Learning and Data Science, May 2012, Florence (IT), Italy
Communication dans un congrès hal-00841017 v1

Sparse factor models for gene co-expression networks.

Yuna Blum , M. Houée , David Causeur
Séminaire de Biostatistiques, Dec 2012, Toulouse (FR), France. non paginé
Communication dans un congrès hal-00841019 v1

Effect of the gene diacylglycerol-O-transferase 1 (DGAT1) polymorphism on the global expression pattern of genes in the mammary gland tissue of dairy cows

Núria Mach , Yuna Blum , David Causeur , Sandrine Lagarrigue , M. A. Smits
62. Annual Meeting of the European Federation of Animal Science (EAAP), Aug 2011, Stavanger, Norway
Communication dans un congrès hal-02747109 v1
Image document

Integrating QTL controlling fatness, lipid metabolites and gene expressions to genetically dissect the adiposity complex trait in a meat chicken cross

Yuna Blum , Olivier O. Demeure , Colette Désert , Hervé Guillou , J Bertrand-Michel et al.
62. Annual Meeting of the European Association for Animal Production (EAAP), Aug 2011, Stavanger, Norway
Communication dans un congrès hal-02748764 v1
Image document

Inférence sur réseaux géniques par Analyse en Facteurs

Yuna Blum , Chloé Friguet , Sandrine Lagarrigue , David Causeur
42èmes Journées de Statistique, 2010, Marseille, France, France
Communication dans un congrès inria-00494802 v1

A factor model to analyze heterogeneity in gene expression in a context of QTL mapping

Yuna Blum , Sandrine Lagarrigue , David Causeur
8th workshop " Statistical Methods for Post-Genomic Data ", Jan 2010, Marseille, France
Communication dans un congrès hal-00459362 v1
Image document

Simulation of data-driven multi-omic benchmark data for cellular deconvolution methods evaluation

Hugo Barbot , David Causeur , Yuna Blum , Magali Richard
IGDR PhD symposium, Nov 2024, Rennes (Campus de Beaulieu), France. 2024
Poster de conférence hal-04790951 v1
Image document

deconvPDAC : a quantifier of PDAC tumor cellular heterogeneity

Yasmina Kermezli , Lucie Lamothe , Jerome Cros , Magali Richard , Yuna Blum
Journées Ouvertes en Biologie, Informatique et Mathématiques (JOBIM 2024), Jun 2024, Toulouse, France.
Poster de conférence hal-04669313 v1
Image document

Multi-omic statistical inference of cellular heterogeneity - COBICA 2024

Hugo Barbot , David Causeur , Yuna Blum , Magali Richard
cobica2024 : Computational Biology of Cancer 2024, Mar 2024, Grenoble, France
Poster de conférence hal-04664694 v1
Image document

AnnotQTL: a new tool to gather functional and comparative information on a genomic region

Frédéric Lecerf , Anthony Bretaudeau , Olivier Sallou , Colette Désert , Yuna Blum et al.
12. Journées Ouvertes en Biologie, Informatique et Mathématiques, Jun 2011, Paris, France. 2011, JOBIM 2011
Poster de conférence hal-02746728 v1
Image document

A factor model to analyse heterogeneity in gene expression in a context of QTL characterization

Yuna Blum , Sandrine Lagarrigue , David Causeur
XXXII International Conference on Animal Genetics (ISAG), Jul 2010, Edinburgh, United Kingdom. 2010, Proceedings of the 32nd International Conference on Animal Genetics
Poster de conférence hal-02754275 v1
Image document

Transcriptome profiling reveals interaction between two QTL for fatness in chicken

Yuna Blum , Guillaume G. Le Mignon , Colette Désert , Frederique Pitel , David Causeur et al.
XXXII International Conference on Animal Genetics (ISAG), Jul 2010, Edinburgh, United Kingdom. 2010, Proceedings of the 32nd International Conference on Animal Genetics
Poster de conférence hal-02754276 v1