Abdelhadi Saoudi

Documents

Publications

The transcription factor Eomes drives a stemness program in CD4+ T cells that promotes anti-tumor immunity in response to immunotherapy

Arantxa Agesta , Chloé Ferrand , Anne-Louise Le Dorze , Cindy Peillex , Nadège Carrié et al.

Immunity, 2026, 59 (7), pp.1876-1893.e7. ⟨10.1016/j.immuni.2026.05.018⟩

Article dans une revue hal-05783210v1

Multiple sclerosis-associated CD226 variant disrupts vitamin D-induced type I Treg differentiation by impairing LFA-1 activation

Saniya Kari , Aymeline Debonlier , Thibault Angles , Beatriz Chaves , Charles Grosjean et al.

The Journal of clinical investigation, 2026, ⟨10.1172/JCI202193⟩

Article dans une revue hal-05752803v1

Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation

Remi Marrocco , Isabelle Bernard , Emeline Joulia , Rebecca Barascud , Anne S Dejean et al.

Cellular and Molecular Life Sciences, 2024, 81 (1), pp.161. ⟨10.1007/s00018-024-05203-5⟩

Article dans une revue inserm-04757623v1

Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4+ T cells during inflammation

Emeline Joulia , Michaël F. Michieletto , Arantxa Agesta , Cindy Peillex , Virgine Girault et al.

Journal of Experimental Medicine, 2024, 221 (2), pp.e20230449. ⟨10.1084/jem.20230449⟩

Article dans une revue hal-04443514v1

Increased levels of circulating soluble CD226 in multiple sclerosis

Saniya Kari , Florence Bucciarelli , Thibault Angles , Anne-Cecile Oster , Pauline Cauboue et al.

Multiple Sclerosis Journal, 2024, 30 (6), pp.654-663. ⟨10.1177/13524585241234489⟩

Article dans une revue hal-04759633v1

THEMIS promotes T cell development and maintenance by rising the signaling threshold of the inhibitory receptor BTLA

Suzanne Mélique , Aurélie Vadel , Nelly Rouquié , Cui Yang , Cyrielle Bories et al.

Proceedings of the National Academy of Sciences of the United States of America, 2024, 121 (20), pp.654-663. ⟨10.1073/pnas.2318773121⟩

Article dans une revue hal-04757063v1

Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions

Elena Morandi , Véronique Adoue , Isabelle Bernard , Ekaterina Friebel , Nicolas Nunez et al.

Neurology Neuroimmunology & Neuroinflammation, 2024, 11 (6), pp.e200306. ⟨10.1212/NXI.0000000000200306⟩

Article dans une revue hal-04780777v1

Cerebrospinal fluid proteomics in recent-onset Narcolepsy type 1 reveals activation of the complement system

Ikram Ayoub , Yves Dauvilliers , Lucie Barateau , Thaïs Vermeulen , Emmanuelle Mouton-Barbosa et al.

Frontiers in Immunology, 2023, 14, pp.1108682. ⟨10.3389/fimmu.2023.1108682⟩

Article dans une revue hal-04291297v1

THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals

Cui Yang , Gaëtan Blaize , Rémi Marrocco , Nelly Rouquié , Cyrielle Bories et al.

Science Signaling, 2022, 15 (742), pp.eabl5343. ⟨10.1126/scisignal.abl5343⟩

Article dans une revue hal-04002199v1

Identification of bacterial lipopeptides as key players in IBS

Camille Petitfils , Sarah Maurel , Gaelle Payros , Amandine Hueber , Bahija Agaiz et al.

Gut, 2022, pp.939-950. ⟨10.1136/gutjnl-2022-328084⟩

Article dans une revue hal-03833107v1

A selective LIS1 requirement for mitotic spindle assembly discriminates distinct T-cell division mechanisms within the T-cell lineage

Jérémy Argenty , Nelly Rouquié , Cyrielle Bories , Suzanne Mélique , Valérie Duplan-Eche et al.

eLife, 2022, 11, pp.e80277. ⟨10.7554/eLife.80277⟩

Article dans une revue hal-04291340v1

Influenza vaccination induces autoimmunity against orexinergic neurons in a mouse model for narcolepsy

Raphaël Bernard-Valnet , David Frieser , Xuan-Hung Nguyen , Leila Khajavi , Clémence Quériault et al.

Brain - A Journal of Neurology , 2022, 145 (6), pp.2018-2030. ⟨10.1093/brain/awab455⟩

Article dans une revue hal-03669984v1

Peripheral Opioid Receptor Blockade Enhances Epithelial Damage in Piroxicam-Accelerated Colitis in IL-10-Deficient Mice

Xavier Mas-Orea , Morgane Sebert , Mehdi Benamar , Camille Petitfils , Catherine Blanpied et al.

International Journal of Molecular Sciences, 2021, 22 (14), pp.7387. ⟨10.3390/ijms22147387⟩

Article dans une revue hal-03330200v1

CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens

Gaëtan Blaize , Hélène Daniels-Treffandier , Meryem Aloulou , Nelly Rouquié , Cui Yang et al.

Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (23), pp.12969-12979. ⟨10.1073/pnas.1917182117⟩

Article dans une revue hal-03016005v1

A Virus Hosted in Malaria-Infected Blood Protects against T Cell-Mediated Inflammatory Diseases by Impairing DC Function in a Type I IFN-Dependent Manner

Ali Hassan , Myriam Wlodarczyk , Mehdi Benamar , Emilie Bassot , Anna Salvioni et al.

mBio, 2020, 11 (2), pp.1-18. ⟨10.1128/mBio.03394-19⟩

Article dans une revue hal-03015978v1

Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy

Marianne Weulersse , Assia Asrir , Andrea C Pichler , Lea Lemaitre , Matthias Braun et al.

Immunity, 2020, 53 (4), pp.824-839.e10. ⟨10.1016/j.immuni.2020.09.006⟩

Article dans une revue hal-03030829v1

Treatment of experimental autoimmune encephalomyelitis with engineered bi-specific Foxp3+ regulatory CD4+ T cells.

Manish Malviya , Abdelhadi Saoudi , Jan Bauer , Simon Fillatreau , Roland Liblau

Journal of Autoimmunity, 2020, 108, pp.102401. ⟨10.1016/j.jaut.2020.102401⟩

Article dans une revue hal-03023558v1

Endogenous control of inflammatory visceral pain by T cell‐derived opioids in IL‐10‐deficient mice

Lilian Basso , Mehdi Benamar , Xavier Mas‐orea , Céline Deraison , Catherine Blanpied et al.

Neurogastroenterology & Motility, 2020, 32 (2), pp.e13743. ⟨10.1111/nmo.13743⟩

Article dans une revue hal-03026676v1

Pre-transplant CD45RC expression on blood T cells differentiates patients with cancer and rejection after kidney transplantation

Anne-Sophie Garnier , Martin Planchais , Jérémie Riou , Clément Jacquemin , Laurence Ordonez et al.

PLoS ONE, 2019, 14 (3), pp.e0214321. ⟨10.1371/journal.pone.0214321⟩

Article dans une revue inserm-02100184v1

Smooth muscle cells-derived CXCL10 prevents endothelial healing through PI3Kγ-dependent T cells response

Adrien Lupieri , Natalia F. Smirnova , Romain Solinhac , Nicole Malet , Mehdi Benamar et al.

Cardiovascular Research, 2019, 116 (2), pp.438-449. ⟨10.1093/cvr/cvz122⟩

Article dans une revue hal-02349692v1

A Natural Variant of the Signaling Molecule Vav1 Enhances Susceptibility to Myasthenia Gravis and Influences the T Cell Receptor Repertoire

Isabelle Bernard , Antoine Sacquin , Sahar Kassem , Mehdi Benamar , Celine Colacios et al.

Frontiers in Immunology, 2018, 9, pp.2399. ⟨10.3389/fimmu.2018.02399⟩

Article dans une revue inserm-02439866v1

The probiotic strain Escherichia coli Nissle 1917 prevents papain-induced respiratory barrier injury and severe allergic inflammation in mice

Thomas Secher , Isabelle Maillet , Claire Mackowiak , Jessica Le Bérichel , Amandine Philippeau et al.

Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-29689-9⟩

Article dans une revue hal-02126575v1

The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4(+) T cells

Guillaume Gaud , Romain Roncagalli , Karima Chaoui , Isabelle Bernard-Cadenat , Julien Familiades et al.

Science Signaling, 2018, 11 (538), ⟨10.1126/scisignal.aar3083⟩

Article dans une revue hal-02117993v1

The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4 + T cells

Guillaume Gaud , Romain Roncagalli , Karima Chaoui , Isabelle Bernard , Julien Familiades et al.

Science Signaling, 2018, 11 (538), pp.eaar3083. ⟨10.1126/scisignal.aar3083⟩

Article dans une revue inserm-04284289v1

Proteomic Analysis of Regulatory T Cells Reveals the Importance of Themis1 in the Control of Their Suppressive Function.

Fanny Duguet , Marie Locard-Paulet , Marlène Marcellin , Karima Chaoui , Isabelle Bernard-Cadenat et al.

Molecular and Cellular Proteomics, 2017, 16 (8), pp.1416-1432. ⟨10.1074/mcp.M116.062745⟩

Article dans une revue hal-01595559v1

Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection

Anne Garreau , Gaëtan Blaize , Jérémy Argenty , Nelly Rouquié , Audrey Tourdès et al.

Journal of Immunology, 2017, 199 (8), pp.2758-2766. ⟨10.4049/jimmunol.1700566⟩

Article dans une revue inserm-04284309v1

Oral Administration of the Probiotic Strain Escherichia coli Nissle 1917 Reduces Susceptibility to Neuroinflammation and Repairs Experimental Autoimmune Encephalomyelitis-Induced Intestinal Barrier Dysfunction

Thomas Secher , Sahar Kassem , Mehdi Benamar , Isabelle Bernard-Cadenat , Michèle Boury et al.

Frontiers in Immunology, 2017, 8, ⟨10.3389/fimmu.2017.01096⟩

Article dans une revue hal-02624001v1

A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation

Sahar Kassem , Guillaume Gaud , Isabelle Bernard-Cadenat , Mehdi Benamar , Anne S. Dejean et al.

PLoS Genetics, 2016, 12 (7), ⟨10.1371/journal.pgen.1006185⟩

Article dans une revue hal-01438135v1

Foxo3 transcription factor drives pathogenic T helper 1 differentiation by inducing the expression of eomes

Caroline Stienne , Michael Michieletto , Mehdi Benamar , Nadège Carrié , Isabelle Bernard-Cadenat et al.

Immunity, 2016, 45 (4), pp.774-787. ⟨10.1016/j.immuni.2016.09.010⟩

Article dans une revue hal-02631699v1

Vaccine-associated inflammatory diseases of the central nervous system

Xuan-Hung Nguyen , Abdelhadi Saoudi , Roland Liblau

Current Opinion in Neurology, 2016, 29 (3), pp.362-371. ⟨10.1097/WCO.0000000000000318⟩

Article dans une revue inserm-04284200v1

Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin

Thomas Secher , Delphine Payros , Camille Brehin , Michèle Boury , Claude Watrin et al.

Infection and Immunity, 2015, 83 (6), pp.2420-2429. ⟨10.1128/IAI.00064-15⟩

Article dans une revue hal-02634629v1

Phosphorus-based dendrimer ABP treats neuroinflammation by promoting IL-10-producing CD4+ T Cells

Myriam Hayder , Marjorie Varilh , Cédric-Olivier Turrin , Abdelhadi Saoudi , A.-M. Caminade et al.

Biomacromolecules, 2015, 16 (11), pp.3425-3433. ⟨10.1021/acs.biomac.5b00643⟩

Article dans une revue hal-01923202v1

An epistatic interaction between Themis1 and Vav1 modulates regulatory T cell function and inflammatory bowel disease development

Christophe Pedros , Guillaume Gaud , Isabelle Bernard-Cadenat , Sahar Kassem , Marianne Chabod et al.

Journal of Immunology, 2015, 195 (4), pp.1608-1616. ⟨10.4049/jimmunol.1402562⟩

Article dans une revue hal-02634615v1

VAV 1 and BAFF , via NF κB pathway, are genetic risk factors for myasthenia gravis

Nili Avidan , Rozen Le Panse , Hanne Harbo , Pia Bernasconi , Konstantinos Poulas et al.

Annals of Clinical and Translational Neurology, 2014, 1 (5), pp.329-339. ⟨10.1002/acn3.51⟩

Article dans une revue inserm-04284319v1

Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response

Natalia F. Smirnova , Stephanie Gayral , Christophe Pedros , Gervaise Loirand , Nathalie Vaillant et al.

Journal of Experimental Medicine, 2014, 211 (9), pp.1779-1792. ⟨10.1084/jem.20131276⟩

Article dans une revue hal-02519407v1

Rho-GTPases as key regulators of T lymphocyte biology

Abdelhadi Saoudi , Sahar Kassem , Anne Dejean , Guillaume Gaud

Small GTPases, 2014, 5 (4), pp.e983862. ⟨10.4161/sgtp.28208⟩

Article dans une revue inserm-04284152v1

Genetic control of HgCl2-induced IgE and autoimmunity by a 117-kb interval on rat chromosome 9 through CD4 CD45RChigh T cells

Christophe Pedros , O Papapietro , C Colacios , A Casemayou , I Bernard et al.

Genes and Immunity, 2013, 14 (4), pp.258-267. ⟨10.1038/gene.2013.21⟩

Article dans une revue inserm-04284227v1

A Higher Risk of Acute Rejection of Human Kidney Allografts Can Be Predicted from the Level of CD45RC Expressed by the Recipients’ CD8 T Cells

Laurence Ordonez , Isabelle Bernard-Cadenat , Marianne Chabod , Jean-François Augusto , Valérie Lauwers-Cances et al.

PLoS ONE, 2013, 8 (7), pp.e69791. ⟨10.1371/journal.pone.0069791⟩

Article dans une revue inserm-02164657v1

Cutting Edge: Neuronal Recognition by CD8 T Cells Elicits Central Diabetes Insipidus

Tanja Scheikl , Béatrice Pignolet , Cécile Dalard , Sabine Desbois , Danièle Raison et al.

Journal of Immunology, 2012, 188 (10), pp.4731-4735. ⟨10.4049/jimmunol.1102998⟩

Article dans une revue inserm-04284304v1

A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease.

Marianne Chabod , Christophe Pedros , Lucille Lamouroux , Céline Colacios , Isabelle Bernard-Cadenat et al.

PLoS Genetics, 2012, 8 (1), pp.e1002461. ⟨10.1371/journal.pgen.1002461⟩

Article dans une revue hal-02650348v1

A Spontaneous Mutation of the Rat Themis Gene Leads to Impaired Function of Regulatory T Cells Linked to Inflammatory Bowel Disease

Marianne Chabod , Christophe Pedros , Lucille Lamouroux , Céline Colacios , Isabelle Bernard et al.

PLoS Genetics, 2012, 8 (1), pp.e1002461. ⟨10.1371/journal.pgen.1002461⟩

Article dans une revue inserm-04284166v1

The p.Arg63Trp polymorphism controls Vav1 functions and Foxp3 regulatory T cell development

Céline Colacios , Audrey Casemayou , Anne Dejean , Frédérique Gaits-Iacovoni , Christophe Pedros et al.

Journal of Experimental Medicine, 2011, 208 (11), pp.2183-2191. ⟨10.1084/jem.20102191⟩

Article dans une revue inserm-04284249v1

Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility

N. Couturier , F. Bucciarelli , R. Nurtdinov , M. Debouverie , C. Lebrun-Frenay et al.

Brain - A Journal of Neurology , 2011, 134 (3), pp.693-703. ⟨10.1093/brain/awr010⟩

Article dans une revue inserm-04284261v1

Effects of BCL-2 over-expression on B cells in transgenic rats and rat hybridomas

Anne-Laure Iscache , Séverine Ménoret , Laurent Tesson , Séverine Rémy , Claire Usal et al.

International Immunology, 2011, 23 (10), pp.625-636. ⟨10.1093/intimm/dxr071⟩

Article dans une revue inserm-04284324v1

Tracking antigen-specific CD8+ T cells in the rat using MHC class I multimers.

Valérie Duplan , Elsa Suberbielle , Catherine E. Napper , Etienne Joly , Abdelhadi Saoudi et al.

Journal of Immunological Methods, 2007, 320 (1-2), pp.30-9. ⟨10.1016/j.jim.2006.11.008⟩

Article dans une revue inserm-00212050v1

The rat Toxo1 locus directs toxoplasmosis outcome and controls parasite proliferation and spreading by macrophage-dependent mechanisms.

Pierre Cavaillès , Véronique Sergent , Cordelia Bisanz , Olivier Papapietro , Céline Colacios et al.

Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (3), pp.744-9. ⟨10.1073/pnas.0506643103⟩

Article dans une revue hal-00171244v1

[The rat Toxo1 locus controls the outcome of the toxoplasmic infection according to a mendelian mode]

Pierre Cavaillès , Cordelia Bisanz , Olivier Papapietro , Céline Colacios , Véronique Sergent et al.

Médecine/Sciences, 2006, 22 (8-9), pp.679-80

Article dans une revue hal-00171242v1

Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage

Julie Cabarrocas , Cécile Cassan , Fay Magnusson , Eliane Piaggio , Lennart T. Mars et al.

Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (22), pp.8453-8458. ⟨10.1073/pnas.0603086103⟩

Article dans une revue hal-03095902v1

Innate refractoriness of the Lewis rat to toxoplasmosis is a dominant trait that is intrinsic to bone marrow-derived cells.

Véronique Sergent , Bastien Cautain , Jamal Khalife , Didier Deslée , Patrick Bastien et al.

Infection and Immunity, 2005, 73 (10), pp.6990-7. ⟨10.1128/IAI.73.10.6990-6997.2005⟩

Article dans une revue hal-00173268v1

Estrogen enhances susceptibility to experimental autoimmune myasthenia gravis by promoting type 1-polarized immune responses.

Laurent Delpy , Victorine Douin-Echinard , Lucile Garidou , Corinne Bruand , Abdelhadi Saoudi et al.

Journal of Immunology, 2005, 175 (8), pp.5050-7

Article dans une revue hal-00458865v1

Functional defect of regulatory CD4+CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis

Anna Balandina , Sandrine Lécart , Philippe Dartevelle , Abdelhadi Saoudi , Sonia Berrih-Aknin

Blood, 2005, 105 (2), pp.735-741. ⟨10.1182/blood-2003-11-3900⟩

Article dans une revue (data paper) hal-05767116v1

Cutting Edge: Vα14-Jα281 NKT Cells Naturally Regulate Experimental Autoimmune Encephalomyelitis in Nonobese Diabetic Mice

Lennart Mars , Véronique Laloux , Karine Goude , Sabine Desbois , Abdelhadi Saoudi et al.

Journal of Immunology, 2002, 168 (12), pp.6007-6011. ⟨10.4049/jimmunol.168.12.6007⟩

Article dans une revue hal-03595264v1

The multiple sclerosis associated CD226 risk variant alters vitamin D-induced human type I regulatory T cell differentiation by impairing LFA-1 activation

Anne Laurence Astier , Saniya Kari , Aymeline Debonlier , Thibault Angles , Beatriz Chaves et al.

2025

Pré-publication, Document de travail hal-05083602v1

Role of vitamin D and CD226 in a T cell regulatory pathway altered in MS

Saniya Kari , Thibault Angles , Elena Morandi , David Frieser , Abdelhadi Saoudi et al.

6th European Congress of Immunology, Sep 2021, Virtual meeting, France. pp.144, ⟨10.1002/eji.202170200⟩

Communication dans un congrès hal-04979442v1

Themis1/vav1 signaling hub controls T cell pathogenicity in a mouse model of multiple sclerosis

Rémi Marrocco , Isabelle Bernard-Cadenat , Renaud Lesourne , Abdelhadi Saoudi

6 th European Congress of Immunology, 1–4 September 2021, Virtual meeting, Sep 2021, Virtual conference, France. OP-030, page 35, ⟨10.1002/eji.202170200⟩

Communication dans un congrès hal-04979860v1

Vav1 cooperate with Themis to modulate regulatory T cell suppressive functions

Christophe Pedros , Marianne Chabod , Anne S. Dejean , Isabelle Bernard-Cadenat , Dominique Lagrange et al.

100. Annual Meeting of the American Association of Immunologists, May 2013, Honolulu, Hawaii, United States

Communication dans un congrès hal-02744604v1

Chargement...

Abdelhadi Saoudi

Publications

Publications

The transcription factor Eomes drives a stemness program in CD4+ T cells that promotes anti-tumor immunity in response to immunotherapy

Multiple sclerosis-associated CD226 variant disrupts vitamin D-induced type I Treg differentiation by impairing LFA-1 activation

Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation

Eomes-dependent mitochondrial regulation promotes survival of pathogenic CD4+ T cells during inflammation

Increased levels of circulating soluble CD226 in multiple sclerosis

THEMIS promotes T cell development and maintenance by rising the signaling threshold of the inhibitory receptor BTLA

Impact of the Multiple Sclerosis-Associated Genetic Variant CD226 Gly307Ser on Human CD8 T-Cell Functions

Cerebrospinal fluid proteomics in recent-onset Narcolepsy type 1 reveals activation of the complement system

THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals

Identification of bacterial lipopeptides as key players in IBS

A selective LIS1 requirement for mitotic spindle assembly discriminates distinct T-cell division mechanisms within the T-cell lineage

Influenza vaccination induces autoimmunity against orexinergic neurons in a mouse model for narcolepsy

Peripheral Opioid Receptor Blockade Enhances Epithelial Damage in Piroxicam-Accelerated Colitis in IL-10-Deficient Mice

CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens

A Virus Hosted in Malaria-Infected Blood Protects against T Cell-Mediated Inflammatory Diseases by Impairing DC Function in a Type I IFN-Dependent Manner

Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy

Treatment of experimental autoimmune encephalomyelitis with engineered bi-specific Foxp3+ regulatory CD4+ T cells.

Endogenous control of inflammatory visceral pain by T cell‐derived opioids in IL‐10‐deficient mice

Pre-transplant CD45RC expression on blood T cells differentiates patients with cancer and rejection after kidney transplantation

Smooth muscle cells-derived CXCL10 prevents endothelial healing through PI3Kγ-dependent T cells response

A Natural Variant of the Signaling Molecule Vav1 Enhances Susceptibility to Myasthenia Gravis and Influences the T Cell Receptor Repertoire

The probiotic strain Escherichia coli Nissle 1917 prevents papain-induced respiratory barrier injury and severe allergic inflammation in mice

The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4(+) T cells

The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4 + T cells

Proteomic Analysis of Regulatory T Cells Reveals the Importance of Themis1 in the Control of Their Suppressive Function.

Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection

Oral Administration of the Probiotic Strain <em>Escherichia coli</em> Nissle 1917 Reduces Susceptibility to Neuroinflammation and Repairs Experimental Autoimmune Encephalomyelitis-Induced Intestinal Barrier Dysfunction

A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation

Foxo3 transcription factor drives pathogenic T helper 1 differentiation by inducing the expression of eomes

Vaccine-associated inflammatory diseases of the central nervous system

Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactin

Phosphorus-based dendrimer ABP treats neuroinflammation by promoting IL-10-producing CD4+ T Cells

An epistatic interaction between <em>Themis1</em> and <em>Vav1</em> modulates regulatory T cell function and inflammatory bowel disease development

VAV 1 and BAFF , via NF κB pathway, are genetic risk factors for myasthenia gravis

Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response

Rho-GTPases as key regulators of T lymphocyte biology

Genetic control of HgCl2-induced IgE and autoimmunity by a 117-kb interval on rat chromosome 9 through CD4 CD45RChigh T cells

A Higher Risk of Acute Rejection of Human Kidney Allografts Can Be Predicted from the Level of CD45RC Expressed by the Recipients’ CD8 T Cells

Cutting Edge: Neuronal Recognition by CD8 T Cells Elicits Central Diabetes Insipidus

A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease.

A Spontaneous Mutation of the Rat Themis Gene Leads to Impaired Function of Regulatory T Cells Linked to Inflammatory Bowel Disease

The p.Arg63Trp polymorphism controls Vav1 functions and Foxp3 regulatory T cell development

Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility

Effects of BCL-2 over-expression on B cells in transgenic rats and rat hybridomas

Tracking antigen-specific CD8+ T cells in the rat using MHC class I multimers.

The rat Toxo1 locus directs toxoplasmosis outcome and controls parasite proliferation and spreading by macrophage-dependent mechanisms.

[The rat Toxo1 locus controls the outcome of the toxoplasmic infection according to a mendelian mode]

Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage

Innate refractoriness of the Lewis rat to toxoplasmosis is a dominant trait that is intrinsic to bone marrow-derived cells.

Estrogen enhances susceptibility to experimental autoimmune myasthenia gravis by promoting type 1-polarized immune responses.

Functional defect of regulatory CD4+CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis

Cutting Edge: Vα14-Jα281 NKT Cells Naturally Regulate Experimental Autoimmune Encephalomyelitis in Nonobese Diabetic Mice

The multiple sclerosis associated CD226 risk variant alters vitamin D-induced human type I regulatory T cell differentiation by impairing LFA-1 activation

Role of vitamin D and CD226 in a T cell regulatory pathway altered in MS

Themis1/vav1 signaling hub controls T cell pathogenicity in a mouse model of multiple sclerosis

Vav1 cooperate with Themis to modulate regulatory T cell suppressive functions