Alain Gobert

DR2, INRAE, Institut de Recherche en Santé Digestive (IRSD), Toulouse, France
51
Documents

Publications

Publications

Epithelial hypusination regulates Helicobacter pylori-induced gastric inflammation

Alain Gobert , Kara Mcnamara , Caroline Hawkins , Mohammad Asim , Daniel Barry et al. Article dans une revue hal-05496769v1

Alterations in polyamine metabolism induced by the pathogen Helicobacter pylori: Implications for gastric inflammation and carcinogenesis

Alain Gobert , Caroline Hawkins , Kara Mcnamara , Keith Wilson

Methods in Enzymology, 2025, Methods in Enzymology, 715, pp.137-153. ⟨10.1016/bs.mie.2025.01.037⟩

Article dans une revue hal-05494888v1

Aconitate Decarboxylase 1 Downregulates Colitis and Maintains Homeostasis of the Gut Metabolome and Microbiome

Kara Mcnamara , Yvonne Latour , Caroline Hawkins , Kamery Williams , Daniel Barry et al.

Gastro Hep Advances, 2025, 4 (9), pp.100748. ⟨10.1016/j.gastha.2025.100748⟩

Article dans une revue hal-05494859v1

Protective role of epithelial deoxyhypusine synthase in colorectal carcinogenesis caused by deletion of the adenomatous polyposis coli gene

Alain Gobert , Kara Mcnamara , Caroline Hawkins , Mohammad Asim , Daniel Barry et al.

Cancer Letters, 2025, 633, pp.218002. ⟨10.1016/j.canlet.2025.218002⟩

Article dans une revue hal-05494852v1

The reverse transsulfuration pathway affects the colonic microbiota and contributes to colitis in mice

Alain Gobert , Yvonne Latour , Kara Mcnamara , Caroline Hawkins , Kamery Williams et al.

Amino Acids, 2024, 56 (1), pp.63. ⟨10.1007/s00726-024-03423-4⟩

Article dans une revue hal-05494900v1

Analysis of the effect of hypusination in myeloid cells on colitis and colitis-associated cancer

Alain Gobert , Jordan Finley , Mohammad Asim , Daniel Barry , Margaret Allaman et al.

Heliyon, 2024, 10 (13), pp.e33838. ⟨10.1016/j.heliyon.2024.e33838⟩

Article dans une revue hal-05494907v1

Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn’s disease

Jia Li , Alan Simmons , Caroline Hawkins , Sophie Chiron , Marisol Ramirez-Solano et al.

Nature Communications, 2024, 15 (1), pp.7204. ⟨10.1038/s41467-024-51580-7⟩

Article dans une revue hal-05494905v1

Spermine oxidase promotes Helicobacter pylori-mediated gastric carcinogenesis through acrolein production

Kara Mcnamara , Johanna Sierra , Yvonne Latour , Caroline Hawkins , Mohammad Asim et al.

Oncogene, 2024, 44 (5), pp.296-306. ⟨10.1038/s41388-024-03218-7⟩

Article dans une revue hal-05494898v1

Hypusination in intestinal epithelial cells protects mice from infectious colitis

Alain Gobert , Caroline Hawkins , Kamery Williams , Lydia Snyder , Daniel Barry et al.

Gut microbes, 2024, 16 (1), ⟨10.1080/19490976.2024.2438828⟩

Article dans une revue hal-05494893v1

Epithelial talin-1 protects mice from Citrobacter rodentium -induced colitis by restricting bacterial crypt intrusion and enhancing T cell immunity

Yvonne Latour , Margaret Allaman , Daniel Barry , Thaddeus Smith , Kamery Williams et al.

Gut microbes, 2023, 15 (1), ⟨10.1080/19490976.2023.2192623⟩

Article dans une revue hal-05494928v1

Electrophilic reactive aldehydes as a therapeutic target in colorectal cancer prevention and treatment

Alain Gobert , Mohammad Asim , Thaddeus Smith , Kamery Williams , Daniel Barry et al.

Oncogene, 2023, 42 (20), pp.1685-1691. ⟨10.1038/s41388-023-02691-w⟩

Article dans une revue hal-05494925v1

Myeloid deletion of talin-1 reduces mucosal macrophages and protects mice from colonic inflammation

Yvonne Latour , Kara Mcnamara , Margaret Allaman , Daniel Barry , Thaddeus Smith et al.

Scientific Reports, 2023, 13 (1), pp.22368. ⟨10.1038/s41598-023-49614-z⟩

Article dans une revue hal-05494918v1

Hypusination Maintains Intestinal Homeostasis and Prevents Colitis and Carcinogenesis by Enhancing Aldehyde Detoxification

Alain Gobert , Thaddeus Smith , Yvonne Latour , Mohammad Asim , Daniel Barry et al.

Gastroenterology, 2023, 165 (3), pp.656-669.e8. ⟨10.1053/j.gastro.2023.05.041⟩

Article dans une revue hal-05494922v1

The nutraceutical electrophile scavenger 2-hydroxybenzylamine (2-HOBA) attenuates gastric cancer development caused by Helicobacter pylori

Alain Gobert , Mohammad Asim , Thaddeus Smith , Kamery Williams , Daniel Barry et al.

Biomedicine and Pharmacotherapy, 2023, 158, pp.114092. ⟨10.1016/j.biopha.2022.114092⟩

Article dans une revue hal-05494931v1

Ornithine Decarboxylase in Gastric Epithelial Cells Promotes the Immunopathogenesis of Helicobacter pylori Infection

Yvonne Latour , Johanna Sierra , Kara Mcnamara , Thaddeus Smith , Paula Luis et al.

Journal of Immunology, 2022, 209 (4), pp.796-805. ⟨10.4049/jimmunol.2100795⟩

Article dans une revue hal-05494932v1

Cystathionine γ-lyase exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation

Yvonne Latour , Johanna Sierra , Jordan Finley , Mohammad Asim , Daniel Barry et al.

JCI Insight, 2022, 7 (12), ⟨10.1172/jci.insight.155338⟩

Article dans une revue hal-05494934v1

Protective Role of Spermidine in Colitis and Colon Carcinogenesis

Alain Gobert , Yvonne Latour , Mohammad Asim , Daniel Barry , Margaret Allaman et al.

Gastroenterology, 2022, 162 (3), pp.813-827.e8. ⟨10.1053/j.gastro.2021.11.005⟩

Article dans une revue hal-05494941v1

Induction and Regulation of the Innate Immune Response in Helicobacter pylori Infection

Alain Gobert , Keith Wilson

Cellular and Molecular Gastroenterology and Hepatology, 2022, 13 (5), pp.1347-1363. ⟨10.1016/j.jcmgh.2022.01.022⟩

Article dans une revue hal-05494937v1

Dicarbonyl Electrophiles Mediate Inflammation-Induced Gastrointestinal Carcinogenesis

Alain Gobert , Olivier Boutaud , Mohammad Asim , Irene Zagol-Ikapitte , Alberto Delgado et al.

Gastroenterology, 2021, 160 (4), pp.1256-1268.e9. ⟨10.1053/j.gastro.2020.11.006⟩

Article dans une revue hal-05495013v1

CCL11 exacerbates colitis and inflammation-associated colon tumorigenesis

Dina Polosukhina , Kshipra Singh , Mohammad Asim , Daniel Barry , Margaret Allaman et al.

Oncogene, 2021, 40 (47), pp.6540-6546. ⟨10.1038/s41388-021-02046-3⟩

Article dans une revue hal-05494943v1

The role of polyamines in gastric cancer

Kara Mcnamara , Alain Gobert , Keith Wilson

Oncogene, 2021, 40 (26), pp.4399-4412. ⟨10.1038/s41388-021-01862-x⟩

Article dans une revue hal-05495008v1

Hypusination Orchestrates the Antimicrobial Response of Macrophages

Alain Gobert , Jordan Finley , Yvonne Latour , Mohammad Asim , Thaddeus Smith et al.

Cell Reports, 2020, 33 (11), pp.108510. ⟨10.1016/j.celrep.2020.108510⟩

Article dans une revue hal-05495012v1

Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling

Johanna Sierra , M. Blanca Piazuelo , Paula Luis , Daniel Barry , Margaret Allaman et al.

Oncogene, 2020, 39 (22), pp.4465-4474. ⟨10.1038/s41388-020-1304-6⟩

Article dans une revue hal-05495018v1

The role of polyamines in the regulation of macrophage polarization and function

Yvonne Latour , Alain Gobert , Keith Wilson

Amino Acids, 2019, 52 (2), pp.151-160. ⟨10.1007/s00726-019-02719-0⟩

Article dans une revue hal-05495023v1

α-Difluoromethylornithine reduces gastric carcinogenesis by causing mutations in Helicobacter pylori cagY

Johanna Sierra , Giovanni Suarez , M. Blanca Piazuelo , Paula Luis , Dara Baker et al.

Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (11), pp.5077-5085. ⟨10.1073/pnas.1814497116⟩

Article dans une revue hal-05495028v1

Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway

Alain Gobert , Yvonne Latour , Mohammad Asim , Jordan Finley , Thomas Verriere et al.

mBio, 2019, 10 (5), ⟨10.1128/mBio.02174-19⟩

Article dans une revue hal-05495022v1

Dietary Arginine Regulates Severity of Experimental Colitis and Affects the Colonic Microbiome

Kshipra Singh , Alain Gobert , Lori Coburn , Daniel Barry , Margaret Allaman et al.

Frontiers in Cellular and Infection Microbiology, 2019, 9, ⟨10.3389/fcimb.2019.00066⟩

Article dans une revue hal-05495025v1

Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection

Alain Gobert , Nicole Al-Greene , Kshipra Singh , Lori Coburn , Johanna Sierra et al.

Frontiers in Immunology, 2018, 9, ⟨10.3389/fimmu.2018.01242⟩

Article dans une revue hal-05495036v1

Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses

Kshipra Singh , Lori Coburn , Mohammad Asim , Daniel Barry , Margaret Allaman et al.

Cancer Research, 2018, 78 (15), pp.4303-4315. ⟨10.1158/0008-5472.CAN-18-0116⟩

Article dans une revue hal-05495043v1

BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability

Yash Choksi , Vishruth Reddy , Kshipra Singh , Caitlyn Barrett , Sarah Short et al.

Mucosal Immunology, 2018, 11 (5), pp.1363-1374. ⟨10.1038/s41385-018-0043-2⟩

Article dans une revue hal-05495040v1

Helicobacter: Inflammation, immunology, and vaccines

Alice Blosse , Philippe Lehours , Keith Wilson , Alain Gobert

Helicobacter, 2018, 23 (S1), ⟨10.1111/hel.12517⟩

Article dans une revue hal-05495031v1

Epidermal growth factor receptor inhibition downregulates Helicobacter pylori -induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis

Johanna Sierra , Mohammad Asim , Thomas Verriere , M Blanca Piazuelo , Giovanni Suarez et al.

Gut, 2018, 67 (7), pp.1247-1260. ⟨10.1136/gutjnl-2016-312888⟩

Article dans une revue hal-05495052v1

Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis

Lori Coburn , Kshipra Singh , Mohammad Asim , Daniel Barry , Margaret Allaman et al.

Oncogene, 2018, 38 (7), pp.1067-1079. ⟨10.1038/s41388-018-0492-9⟩

Article dans une revue hal-05495032v1

Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications

Dana Hardbower , Mohammad Asim , Paula Luis , Kshipra Singh , Daniel Barry et al.

Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (5), ⟨10.1073/pnas.1614958114⟩

Article dans une revue hal-05495059v1

Effect of CO2 on Peroxynitrite-Mediated Bacteria Killing: Response to Tsikas et al.

Alain Gobert , Keith Wilson

Trends in Microbiology, 2017, 25 (8), pp.602-603. ⟨10.1016/j.tim.2017.05.009⟩

Article dans une revue hal-05495045v1

Human and Helicobacter pylori Interactions Determine the Outcome of Gastric Diseases

Alain Gobert , Keith Wilson

Current Topics in Microbiology and Immunology, 2017, Current Topics in Microbiology and Immunology, 400, pp.27-52. ⟨10.1007/978-3-319-50520-6_2⟩

Article dans une revue hal-05495058v1

Polyamine- and NADPH-dependent generation of ROS during Helicobacter pylori infection: A blessing in disguise

Alain Gobert , Keith Wilson

Free Radical Biology and Medicine, 2017, 105, pp.16-27. ⟨10.1016/j.freeradbiomed.2016.09.024⟩

Article dans une revue hal-05495075v1

The Immune Battle against Helicobacter pylori Infection: NO Offense

Alain Gobert , Keith Wilson

Trends in Microbiology, 2016, 24 (5), pp.366-376. ⟨10.1016/j.tim.2016.02.005⟩

Article dans une revue hal-05495079v1

The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria

Kshipra Singh , Nicole Al-Greene , Thomas Verriere , Lori Coburn , Mohammad Asim et al.

PLoS Pathogens, 2016, 12 (10), pp.e1005984. ⟨10.1371/journal.ppat.1005984⟩

Article dans une revue hal-05495070v1

Cellular responses to attaching and effacing bacteria: activation and implication of the innate immune system.

Alain Gobert , Keith Wilson , Christine Martin

Archivum Immunologiae et Therapiae Experimentalis, 2005, 53 (3), pp.234-44. ⟨10.1074/jbc.C400498200⟩

Article dans une revue hal-05495936v1

Mouse Strain Susceptibility to Trypanosome Infection: An Arginase-Dependent Effect

Sébastien Duleu , Philippe Vincendeau , Pierrette Courtois , Silla Semballa , Isabelle Lagroye et al.

Journal of Immunology, 2004, 172 (10), pp.6298-6303. ⟨10.4049/jimmunol.172.10.6298⟩

Article dans une revue hal-05495929v1
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Helicobacter pylori Heat Shock Protein 60 Mediates Interleukin-6 Production by Macrophages via a Toll-like Receptor (TLR)-2-, TLR-4-, and Myeloid Differentiation Factor 88-independent Mechanism

Alain Gobert , Jean-Christophe Bambou , Catherine Werts , Viviane Balloy , Michel Chignard et al.

Journal of Biological Chemistry, 2004, 279 (1), pp.245-250. ⟨10.1074/jbc.M307858200⟩

Article dans une revue hal-05495925v1

Protective Role of Arginase in a Mouse Model of Colitis

Alain Gobert , Yulan Cheng , Mahmood Akhtar , Benjamin Mersey , Darren Blumberg et al.

Journal of Immunology, 2004, 173 (3), pp.2109-2117. ⟨10.4049/jimmunol.173.3.2109⟩

Article dans une revue hal-05495931v1

Cutting Edge: Cyclooxygenase-2 Activation Suppresses Th1 Polarization in Response to Helicobacter pylori

Frank Meyer , Kalathur Ramanujam , Alain Gobert , Stephen James , Keith Wilson

Journal of Immunology, 2003, 171 (8), pp.3913-3917. ⟨10.4049/jimmunol.171.8.3913⟩

Article dans une revue hal-05495921v1

Arginases in parasitic diseases

Philippe Vincendeau , Alain Gobert , Sylvie Daulouède , Daniel Moynet , M Djavad Mossalayi

Trends in Parasitology, 2003, 19 (1), pp.9-12. ⟨10.1016/s1471-4922(02)00010-7⟩

Article dans une revue istex hal-05495919v1

Helicobacter pylori Induces Macrophage Apoptosis by Activation of Arginase II

Alain Gobert , Yulan Cheng , Jian-Ying Wang , Jean-Luc Boucher , Ramaswamy Iyer et al.

Journal of Immunology, 2002, 168 (9), pp.4692-4700. ⟨10.4049/jimmunol.168.9.4692⟩

Article dans une revue hal-05495912v1

Cutting Edge: Urease Release by Helicobacter pylori Stimulates Macrophage Inducible Nitric Oxide Synthase

Alain Gobert , Benjamin Mersey , Yulan Cheng , Darren Blumberg , Jamie Newton et al.

Journal of Immunology, 2002, 168 (12), pp.6002-6006. ⟨10.4049/jimmunol.168.12.6002⟩

Article dans une revue hal-05495914v1

Helicobacter pylori arginase inhibits nitric oxide production by eukaryotic cells: A strategy for bacterial survival

Alain Gobert , David Mcgee , Mahmood Akhtar , George Mendz , Jamie Newton et al.

Proceedings of the National Academy of Sciences of the United States of America, 2001, 98 (24), pp.13844-13849. ⟨10.1073/pnas.241443798⟩

Article dans une revue hal-05495911v1

l -Arginine Availability Modulates Local Nitric Oxide Production and Parasite Killing in Experimental Trypanosomiasis

Alain Gobert , Sylvie Daulouede , Michel Lepoivre , Jean Luc Boucher , Bernard Bouteille et al.

Infection and Immunity, 2000, 68 (8), pp.4653-4657. ⟨10.1128/IAI.68.8.4653-4657.2000⟩

Article dans une revue hal-05495908v1

Mechanism of Extracellular Thiol Nitrosylation by N2O3 Produced by Activated Macrophages

Alain Gobert , Philippe Vincendeau , Djavad Mossalayi , Bernard Veyret

Nitric Oxide: Biology and Chemistry, 1999, 3 (6), pp.467-472. ⟨10.1006/niox.1999.0260⟩

Article dans une revue istex hal-05495903v1

Murine Macrophages Use Oxygen- and Nitric Oxide-Dependent Mechanisms To Synthesize S -Nitroso-Albumin and To Kill Extracellular Trypanosomes

Alain Gobert , Silla Semballa , Sylvie Daulouede , Sophie Lesthelle , Murielle Taxile et al.

Infection and Immunity, 1998, 66 (9), pp.4068-4072. ⟨10.1128/IAI.66.9.4068-4072.1998⟩

Article dans une revue hal-05495898v1