Alexandre Boissonnas

49
Documents

Présentation

CURRENT POSITION

Research Director and team leader at the French government Institution Inserm, Institut National de la recherche scientifique et médicale at Centre d’immunologie et des maladies infectieuses CIMI, U1135, Hôpital Pitié-Salpêtrière, Paris, France.

EDUCATION

2014 Official ability to conduct PhD students of the French University UPMC, Paris, France

2000-04 PhD in immunology, Paris VI, Pierre et Marie Curie University, Paris, France

Defended January the 15th 2004

1999-00 Master in Immunology of the Pasteur Institute Paris

VII, Jussieu, Paris, France

PROFESSIONNAL EXPERIENCES

Academic research

2021 Research Director position at Inserm.

2019 Team Leader: “Chemokines, Phagocytes and Inflammation”. Centre d’immunologie et des maladies infectieuses CIMI, CR7, U1135, Hôpital Pitié-Salpêtrière, Paris, France. (HCERES validation).

2018-19 Visiting Scholar in Krummel’s lab, Dept of Pathology UCSF, San Francisco USA.

Immune landscape of human tumors (ImmunoProfiler Consortium).

2014 Group Leader in C. Combadière team, CIMI, CR7, U1135, Hôpital Pitié-Salpêtrière, Paris, France.

Dynamic of the mononuclear phagocytic system.

2009 Principal Investigator INSERM, Laboratoire Immunité et Infection UMR-s945.

Hôpital Pitié-Salpêtrière, Paris, France.

Chemokines implication in T cell and tumor associated macrophages interactions.

2004-09 Post-Doctoral Fellow, Laboratoire immunité et Cancer U932

Institut Curie Paris France (Dr S. Amigorena).

Imaging T cell, Dendritic cell and Tumor cell interactions in vivo.**

1999-04 Master and PhD in Immunology, Laboratoire d’Immunologie Cellulaire U543.

Hôpital Pitié-Salpêtrière, Paris, France. (Dr B.Combadière)

Antigenic variants and T cell homeostasis.

1998 Summer Internship (8 weeks), Laboratoire d’Immunologie Cellulaire U543.

Hopital Pitié-Salpêtrière, Paris, France. (Dr B.Combadière)

Role of TCR altered peptide ligands on T cell apoptosis

1997 Summer internship (4 weeks), Laboratoire d’Immunologie Cellulaire U543.

Hopital Pitié-Salpêtrière, Paris, France. (Pr. B. Autran, PU PH)

Longitudinal study of Tri-therapy-treated HIV patients by flow cytometry**

Pharmaceutical research

1996 Summer internship (7 weeks), Département de Pharmacologie.

Rhône Poulenc Rorer, Maison-Alfort, France (Dr I. Cavero)

In vivo study of hypoglycemic molecules in rats.**

1995 Summer internship (5 weeks), Département de Pharmacologie.

Rhône Poulenc Rorer, Maison-Alfort, France (Dr I. Cavero)

Study on rat explanted organ culture of anticancer and vasoconstrictor drugs side effects**

1994 Summer internship (5 weeks), Département de Pharmacologie.

Rhône Poulenc Rorer, Maison-Alfort, France (Dr I. Cavero)

Technical assistance on explanted organ cultures from rats and guinea pigs**

Publications

Publications

Combined pharmacological targeting of CD9+ progenitors alleviates obesity-induced adipose tissue fibrosis and metabolic impairment

Clémentine Rebière , Ana Letícia Silveira , Amanda Oliveira , Christine Rouault , Solia Adriouch et al.

Cell Reports Medicine, 2025, 6 (7), pp.102197. ⟨10.1016/j.xcrm.2025.102197⟩

Article dans une revue hal-05417306v1
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Regulatory T Cells Poise the Myeloid Landscape after Chemotherapy in Lung Tumors

Eléonore Weber-Delacroix , Marylou Panouillot , Marie Laviron , François Lanthiez , Tristan Philippe et al.

Cancer Immunology Research, 2025, 13 (10), pp.1561 - 1575. ⟨10.1158/2326-6066.cir-25-0103⟩

Article dans une revue hal-05378474v1
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Visualizing the spatial organization of monocytes, interstitial macrophages, and tissue-specific macrophages in situ

Maxime Petit , Eléonore Weber-Delacroix , François Lanthiez , Sandrine Barthélémy , Noëlline Guillou et al.

Cell Reports, 2024, 43 (10), pp.114847. ⟨10.1016/j.celrep.2024.114847⟩

Article dans une revue (data paper) hal-04889092v1
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Loss of embryonically-derived Kupffer cells during hypercholesterolemia accelerates atherosclerosis development

Rebecca Fima , Sébastien Dussaud , Cheïma Benbida , Margault Blanchet , François Lanthiez et al.

Nature Communications, 2024, 15 (1), pp.8341. ⟨10.1038/s41467-024-52735-2⟩

Article dans une revue hal-04716830v1
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Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages

Nilushi de Silva , Johan Siewiera , Chantal Alkhoury , Guilherme Nader , Francesca Nadalin et al.

Nature Aging, 2023, 3 (10), pp.1251-1268. ⟨10.1038/s43587-023-00488-w⟩

Article dans une revue hal-04290463v1

Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages

Nilushi de Silva , Johan Siewiera , Chantal Alkhoury , Guilherme Nader , Francesca Nadalin et al.

Nature Aging, 2023, 3 (10), pp.1251-1268. ⟨10.1038/s43587-023-00488-w⟩

Article dans une revue hal-04290165v1
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Two New Neutrophil Subsets Define a Discriminating Sepsis Signature

Aïda Meghraoui-Kheddar , Benjamin Chousterman , Noëlline Guillou , Sierra Barone , Samuel Granjeaud et al.

American Journal of Respiratory and Critical Care Medicine, 2022, 205 (1), pp.46-59. ⟨10.1164/rccm.202104-1027OC⟩

Article dans une revue hal-03419725v1
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Discovering dominant tumor immune archetypes in a pan-cancer census

Alexis Combes , Bushra Samad , Jessica Tsui , Nayvin Chew , Peter Yan et al.

Cell, 2022, 185 (1), pp.184-203.e19. ⟨10.1016/j.cell.2021.12.004⟩

Article dans une revue hal-03549512v1

Modulating the tumor-associated macrophage landscape

Alexandre Boissonnas , Christophe Combadière

Nature Immunology, 2022, 23 (4), pp.481-482. ⟨10.1038/s41590-022-01159-5⟩

Article dans une revue hal-03983376v1

Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer

Adriana Mujal , Alexis Combes , Arjun Rao , Mikhail Binnewies , Bushra Samad et al.

Cancer Immunology Research, 2022, 10 (4), pp.403-419. ⟨10.1158/2326-6066.CIR-21-0588⟩

Article dans une revue hal-04027478v1
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Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer

Marie Laviron , Maxime Petit , Eléonore Weber-Delacroix , Alexis J Combes , Arjun Rao Arkal et al.

Cell Reports, 2022, 39 (8), pp.110865. ⟨10.1016/j.celrep.2022.110865⟩

Article dans une revue hal-03699958v1

TREM-1 orchestrates angiotensin II–induced monocyte trafficking and promotes experimental abdominal aortic aneurysm

Marie Vandestienne , Yujiao Zhang , Icia Santos-Zas , Rida Al-Rifai , Jeremie Joffre et al.

Journal of Clinical Investigation, 2021, 131 (2), pp.e142468. ⟨10.1172/JCI142468⟩

Article dans une revue inserm-03833065v1
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LOX-1-Expressing Immature Neutrophils Identify Critically-Ill COVID-19 Patients at Risk of Thrombotic Complications

Behazine Combadière , Lucille Adam , Noëlline Guillou , Paul Quentric , Pierre Rosenbaum et al.

Frontiers in Immunology, 2021, 12, pp.752612. ⟨10.3389/fimmu.2021.752612⟩

Article dans une revue hal-03375967v1
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Early activation of the cardiac CX3CL1/CX3CR1 axis delays β-adrenergic-induced heart failure

M. Flamant , N. Mougenot , E. Balse , L. Le Fèvre , F. Atassi et al.

Scientific Reports, 2021, 11 (1), pp.17982. ⟨10.1038/s41598-021-97493-z⟩

Article dans une revue hal-03354268v1
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Ibrutinib induces multiple functional defects in the neutrophil response against Aspergillus fumigatus

Damien Blez , Marion Blaize , Carole Soussain , Alexandre Boissonnas , Aïda Meghraoui-Kheddar et al.

Haematologica, 2020, 105 (2), pp.478-489. ⟨10.3324/haematol.2019.219220⟩

Article dans une revue hal-02486017v1
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Revising CX3CR1 Expression on Murine Classical and Non-classical Monocytes

Aïda Meghraoui-Kheddar , Sandrine Barthélémy , Alexandre Boissonnas , Christophe Combadière

Frontiers in Immunology, 2020, 11, pp.1117. ⟨10.3389/fimmu.2020.01117⟩

Article dans une revue hal-02898020v1
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Imaging resident and recruited macrophage contribution to Wallerian degeneration

Alexandre Boissonnas , Floriane Louboutin , Marie Laviron , Pierre-Louis Loyher , Elodie Reboussin et al.

Journal of Experimental Medicine, 2020, 217 (11), ⟨10.1084/jem.20200471⟩

Article dans une revue hal-03047020v1
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Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing

Denise Gay , Giulia Ghinatti , Christian Guerrero-Juarez , Rubén A Ferrer , Federica Ferri et al.

Science Advances , 2020, 6 (12), pp.eaay3704. ⟨10.1126/sciadv.aay3704⟩

Article dans une revue hal-02540226v1
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Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis

Sophie Tran , Ines Baba , Lucie Poupel , Sébastien Dussaud , Martine Moreau et al.

Immunity, 2020, 53 (3), pp.627-640.e5. ⟨10.1016/j.immuni.2020.06.003⟩

Article dans une revue hal-02967896v1
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Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer

Aitziber Buqué , Norma Bloy , Maria Perez-Lanzón , Kristina Iribarren , Juliette Humeau et al.

Nature Communications, 2020, 11, pp.3819. ⟨10.1038/s41467-020-17644-0⟩

Article dans une revue hal-03994636v1
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Sepsis Triggers a Late Expansion of Functionally Impaired Tissue-Vascular Inflammatory Monocytes During Clinical Recovery

Camille Baudesson De Chanville , Benjamin Glenn Chousterman , Pauline Hamon , Marie Laviron , Noelline Guillou et al.

Frontiers in Immunology, 2020, 11, pp.675. ⟨10.3389/fimmu.2020.00675⟩

Article dans une revue hal-02798381v1
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Publisher Correction: Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer

Aitziber Buqué , Norma Bloy , Maria Perez-Lanzón , Kristina Iribarren , Juliette Humeau et al.

Nature Communications, 2020, 11 (1), pp.4787. ⟨10.1038/s41467-020-18719-8⟩

Article dans une revue hal-03994694v1
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CCR2-Dependent Recruitment of Tregs and Monocytes Following Radiotherapy Is Associated with TNFα-Mediated Resistance

Michele Mondini , Pierre-Louis Loyher , Pauline Hamon , Marine Gerbé de Thoré , Marie Laviron et al.

Cancer Immunology Research, 2019, 7 (3), pp.376-387. ⟨10.1158/2326-6066.CIR-18-0633⟩

Article dans une revue hal-02339936v1
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Ontogeny of Tumor-Associated Macrophages

Marie Laviron , Alexandre Boissonnas

Frontiers in Immunology, 2019, 10, pp.1799. ⟨10.3389/fimmu.2019.01799⟩

Article dans une revue hal-02279585v1
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Tracking Monocytes and Macrophages in Tumors With Live Imaging

Marie Laviron , Christophe Combadière , Alexandre Boissonnas

Frontiers in Immunology, 2019, 10, pp.1201. ⟨10.3389/fimmu.2019.01201⟩

Article dans une revue hal-02172263v1

CSF1R inhibition prevents radiation pulmonary fibrosis by depletion of interstitial macrophages

Lydia Meziani , Michele Mondini , Benoît Petit , Alexandre Boissonnas , Vincent Thomas de Montpreville et al.

European Respiratory Journal, 2018, 51 (3), pp.1702120. ⟨10.1183/13993003.02120-2017⟩

Article dans une revue hal-04003775v1

CSF1R inhibition prevents radiation pulmonary fibrosis by depletion of interstitial macrophages

Lydia Meziani , Michele Mondini , Benoît Petit , Alexandre Boissonnas , Vincent Thomas de Montpreville et al.

European Respiratory Journal, 2018, 51 (3), pp.1702120. ⟨10.1183/13993003.02120-2017⟩

Article dans une revue hal-04515426v1
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Macrophages of distinct origins contribute to tumor development in the lung

Pierre-Louis Loyher , Pauline Hamon , Marie Laviron , Aïda Meghraoui-Kheddar , Elena Goncalves et al.

Journal of Experimental Medicine, 2018, 215 (10), pp.2536 - 2553. ⟨10.1084/jem.20180534⟩

Article dans une revue hal-01913815v1
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Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota

Aurélie Durand , Alexandra Audemard-Verger , Vincent Guichard , Raphaël Mattiuz , Arnaud Delpoux et al.

Nature Communications, 2018, 9 (1), pp.68. ⟨10.1038/s41467-017-02458-4⟩

Article dans une revue hal-03863818v1

Critical Role for Skin-Derived Migratory DCs and Langerhans Cells in TFH and GC Responses after Intradermal Immunization

Clément Levin , Olivia Bonduelle , Charles Nuttens , Charlotte Primard , Bernard Verrier et al.

Journal of Investigative Dermatology, 2017, 137 (9), pp.1905-1913. ⟨10.1016/j.jid.2017.04.016⟩

Article dans une revue hal-04002647v1
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Unveiling Cerebral Leishmaniasis: parasites and brain inflammation in Leishmania donovani infected mice

Guilherme D. Melo , Sophie Goyard , Laurence Fiette , Alexandre Boissonnas , Christophe Combadiere et al.

Scientific Reports, 2017, 7, pp.8454. ⟨10.1038/s41598-017-09085-5⟩

Article dans une revue hal-01581802v1
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Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity

Marion Duriez , Yassmina Mandouri , Bouchra Lekbaby , Hualin Wang , Aurélie Schnuriger et al.

Journal of Hepatology, 2017, 67 (4), pp.687-699. ⟨10.1016/j.jhep.2017.05.025⟩

Article dans une revue inserm-03990705v1
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Macrophages Induce Long-Term Trapping of γδ T Cells with Innate-like Properties within Secondary Lymphoid Organs in the Steady State

Alexandra Audemard-Verger , Matthieu Rivière , Aurélie Durand , Elisa Peranzoni , Vincent Guichard et al.

Journal of Immunology, 2017, 199 (6), pp.1998-2007. ⟨10.4049/jimmunol.1700430⟩

Article dans une revue hal-03863963v1

Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity

Marion Duriez , Yassmina Mandouri , Bouchra Lekbaby , Hualin Wang , Aurélie Schnuriger et al.

Journal of Hepatology, 2017, 67 (4), pp.687-699. ⟨10.1016/j.jhep.2017.05.025⟩

Article dans une revue hal-04002677v1
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New insights into experimental visceral leishmaniasis: Real-time in vivo imaging of Leishmania donovani virulence

Guilherme Dias de Melo , Sophie Goyard , Hervé Lecoeur , Eline Rouault , Pascale Pescher et al.

PLoS Neglected Tropical Diseases, 2017, 11 (9), pp.e0005924. ⟨10.1371/journal.pntd.0005924⟩

Article dans une revue hal-03504212v1

CX3CR1-dependent endothelial margination modulates Ly6Chigh monocyte systemic deployment upon inflammation in mice

Pauline Hamon , Pierre-Louis Loyher , Camille Baudesson de Chanville , Fabrice Licata , Christophe Combadière et al.

Blood, 2017, 129 (10), pp.1296-1307. ⟨10.1182/blood-2016-08-732164⟩

Article dans une revue hal-04002521v1
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Calcineurin inhibitors impair neutrophil activity against Aspergillus fumigatus in allogenic hematopoietic stem cell transplant recipients

Sébastien Imbert , Priscillia Bresler , Alexandre Boissonnas , Lauraine Gauthier , Laëtitia Souchet et al.

Journal of Allergy and Clinical Immunology, 2016, 138 (3), pp.860-868. ⟨10.1016/j.jaci.2016.02.026⟩

Article dans une revue hal-01301151v1

Ly6Chigh Monocytes Protect against Kidney Damage during Sepsis via a CX3CR1-Dependent Adhesion Mechanism

B. G. Chousterman , Alexandre Boissonnas , L. Poupel , C. Baudesson de Chanville , J. Adam et al.

Journal of the American Society of Nephrology, 2016, 27 (3), pp.792-803 ⟨10.1681/ASN.2015010009⟩

Article dans une revue hal-01292451v1
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CCR2 Influences T Regulatory Cell Migration to Tumors and Serves as a Biomarker of Cyclophosphamide Sensitivity

Pierre-Louis Loyher , Juliette Rochefort , Camille Baudesson de Chanville , Pauline Hamon , Géraldine Lescaille et al.

Cancer Research, 2016, 76 (22), pp.6483 - 6494. ⟨10.1158/0008-5472.CAN-16-0984⟩

Article dans une revue hal-01397194v1

Tracking Mouse Bone Marrow Monocytes <em>In Vivo</em>

Pauline Hamon , Mathieu P Rodero , Christophe Combadiere , Alexandre Boissonnas

Journal of visualized experiments : JoVE, 2015, 96, ⟨10.3791/52476⟩

Article dans une revue hal-02998291v1
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Immune surveillance of the lung by migrating tissue monocytes

Mathieu P Rodero , Lucie Poupel , Pierre-Louis Loyher , Pauline Hamon , Fabrice Licata et al.

eLife, 2015, 4, pp.e07847. ⟨10.7554/eLife.07847⟩

Article dans une revue hal-01310477v1
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CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production

Ludovic Arnold , Hélène Perrin , Camille Baudesson de Chanville , Marielle Saclier , Patricia Hermand et al.

Nature Communications, 2015, 6, pp.8972. ⟨10.1038/ncomms9972⟩

Article dans une revue hal-01514445v1

In vivo imaging reveals a pioneer wave of monocyte recruitment into mouse skin wounds

M.P. Rodero , F. Licata , L. Poupel , P. Hamon , K. Khosrotehrani et al.

PLoS ONE, 2014, 9 (10), pp.e108212. ⟨10.1371/journal.pone.0108212⟩

Article dans une revue hal-01369479v1
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CD8+ Tumor-Infiltrating T Cells Are Trapped in the Tumor-Dendritic Cell Network

Alexandre Boissonnas , Fabrice Licata , Lucie Poupel , Sébastien Jacquelin , Luc Fetler et al.

Neoplasia, 2013, 15 (1), pp.85. ⟨10.1593/neo.121572⟩

Article dans une revue hal-01586881v1

Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes.

Alexandre Boissonnas , Alix Scholer-Dahirel , Virginie Simon-Blancal , Luigia Pace , Fabien Valet et al.

Immunity, 2010, 32 (2), pp.266-78. ⟨10.1016/j.immuni.2009.11.015⟩

Article dans une revue hal-00553080v1

In vivo cellular imaging of lymphocyte tracking by MRI: A tumor model approach to cell-based anticancer therapy

P. Smirnov , E. Lavergne , F. Gazeau , M. Lewin , A. Boissonnas et al.

Magnetic Resonance in Medicine, 2006, 56(3), pp.498-508

Article dans une revue hal-00098654v1

In vivo cellular imaging of lymphocyte trafficking by MRI : a tumor model approach to cell-based anticancer therapy

Pierre Smirnov , Elise Lavergne , Florence Gazeau , Maïté Lewin , Alexandre Boissonnas et al.

Magnetic Resonance in Medicine, 2006, 56 (3), pp.498-508. ⟨10.1002/mrm.20996⟩

Article dans une revue hal-00348207v1