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Alexandre Boissonnas

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Présentation

CURRENT POSITION **Research Director and team leader at the French government Institution Inserm**, Institut National de la recherche scientifique et médicale at Centre d’immunologie et des maladies infectieuses CIMI, U1135, Hôpital Pitié-Salpêtrière, Paris, France. EDUCATION 2014 Official ability to conduct PhD students of the French University UPMC, Paris, France 2000-04 PhD in immunology, Paris VI, Pierre et Marie Curie University, Paris, France Defended January the 15th 2004 1999-00 Master in Immunology of the Pasteur Institute Paris VII, Jussieu, Paris, France PROFESSIONNAL EXPERIENCES **Academic research** 2021 Research Director position at Inserm. 2019 Team Leader: “**Chemokines, Phagocytes and Inflammation”**. Centre d’immunologie et des maladies infectieuses CIMI, CR7, U1135, Hôpital Pitié-Salpêtrière, Paris, France. (HCERES validation). 2018-19 Visiting Scholar in Krummel’s lab, Dept of Pathology UCSF, San Francisco USA. **Immune landscape of human tumors (ImmunoProfiler Consortium).** 2014 Group Leader in C. Combadière team, CIMI, CR7, U1135, Hôpital Pitié-Salpêtrière, Paris, France. **Dynamic of the mononuclear phagocytic system.** 2009 Principal Investigator INSERM, Laboratoire Immunité et Infection UMR-s945. Hôpital Pitié-Salpêtrière, Paris, France. **Chemokines implication in T cell and tumor associated macrophages interactions.** 2004-09 Post-Doctoral Fellow, Laboratoire immunité et Cancer U932 Institut Curie Paris France (Dr S. Amigorena). Imaging T cell, Dendritic cell and Tumor cell interactions in vivo.** 1999-04 Master and PhD in Immunology, Laboratoire d’Immunologie Cellulaire U543. Hôpital Pitié-Salpêtrière, Paris, France. (Dr B.Combadière) **Antigenic variants and T cell homeostasis.** 1998 Summer Internship (8 weeks), Laboratoire d’Immunologie Cellulaire U543. Hopital Pitié-Salpêtrière, Paris, France. (Dr B.Combadière) **Role of TCR altered peptide ligands on T cell apoptosis** 1997 Summer internship (4 weeks), Laboratoire d’Immunologie Cellulaire U543. Hopital Pitié-Salpêtrière, Paris, France. (Pr. B. Autran, PU PH) Longitudinal study of Tri-therapy-treated HIV patients by flow cytometry** **Pharmaceutical research** 1996 Summer internship (7 weeks), Département de Pharmacologie. Rhône Poulenc Rorer, Maison-Alfort, France (Dr I. Cavero) In vivo study of hypoglycemic molecules in rats.** 1995 Summer internship (5 weeks), Département de Pharmacologie. Rhône Poulenc Rorer, Maison-Alfort, France (Dr I. Cavero) Study on rat explanted organ culture of anticancer and vasoconstrictor drugs side effects** 1994 Summer internship (5 weeks), Département de Pharmacologie. Rhône Poulenc Rorer, Maison-Alfort, France (Dr I. Cavero) Technical assistance on explanted organ cultures from rats and guinea pigs**

Publications

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Two New Neutrophil Subsets Define a Discriminating Sepsis Signature

Aïda Meghraoui-Kheddar , Benjamin Chousterman , Noëlline Guillou , Sierra Barone , Samuel Granjeaud
American Journal of Respiratory and Critical Care Medicine, 2022, 205 (1), pp.46-59. ⟨10.1164/rccm.202104-1027OC⟩
Article dans une revue hal-03419725v1

Modulating the tumor-associated macrophage landscape

Alexandre Boissonnas , Christophe Combadière
Nature Immunology, 2022, 23 (4), pp.481-482. ⟨10.1038/s41590-022-01159-5⟩
Article dans une revue hal-03983376v1
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Discovering dominant tumor immune archetypes in a pan-cancer census

Alexis Combes , Bushra Samad , Jessica Tsui , Nayvin Chew , Peter Yan
Cell, 2022, 185 (1), pp.184-203.e19. ⟨10.1016/j.cell.2021.12.004⟩
Article dans une revue hal-03549512v1

Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer

Adriana Mujal , Alexis Combes , Arjun Rao , Mikhail Binnewies , Bushra Samad
Cancer Immunology Research, 2022, 10 (4), pp.403-419. ⟨10.1158/2326-6066.CIR-21-0588⟩
Article dans une revue hal-04027478v1
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Tumor-associated macrophage heterogeneity is driven by tissue territories in breast cancer

Marie Laviron , Maxime Petit , Eléonore Weber-Delacroix , Alexis J Combes , Arjun Rao Arkal
Cell Reports, 2022, 39 (8), pp.110865. ⟨10.1016/j.celrep.2022.110865⟩
Article dans une revue hal-03699958v1

Early activation of the cardiac CX3CL1/CX3CR1 axis delays β-adrenergic-induced heart failure

M. Flamant , N. Mougenot , E. Balse , L. Le Fèvre , F. Atassi
Scientific Reports, 2021, 11 (1), pp.17982. ⟨10.1038/s41598-021-97493-z⟩
Article dans une revue hal-04165219v1
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LOX-1-Expressing Immature Neutrophils Identify Critically-Ill COVID-19 Patients at Risk of Thrombotic Complications

Behazine Combadière , Lucille Adam , Noëlline Guillou , Paul Quentric , Pierre Rosenbaum
Frontiers in Immunology, 2021, 12, pp.752612. ⟨10.3389/fimmu.2021.752612⟩
Article dans une revue hal-03375967v1
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Ibrutinib induces multiple functional defects in the neutrophil response against Aspergillus fumigatus

Damien Blez , Marion Blaize , Carole Soussain , Alexandre Boissonnas , Aïda Meghraoui-Kheddar
Haematologica, 2020, 105 (2), pp.478-489. ⟨10.3324/haematol.2019.219220⟩
Article dans une revue hal-02486017v1
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Phagocytosis of Wnt inhibitor SFRP4 by late wound macrophages drives chronic Wnt activity for fibrotic skin healing

Denise Gay , Giulia Ghinatti , Christian Guerrero-Juarez , Rubén A Ferrer , Federica Ferri
Science Advances , 2020, 6 (12), pp.eaay3704. ⟨10.1126/sciadv.aay3704⟩
Article dans une revue hal-02540226v1
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Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis

Sophie Tran , Ines Baba , Lucie Poupel , Sébastien Dussaud , Martine Moreau
Immunity, 2020, 53 (3), pp.627-640.e5. ⟨10.1016/j.immuni.2020.06.003⟩
Article dans une revue hal-02967896v1
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Revising CX3CR1 Expression on Murine Classical and Non-classical Monocytes

Aïda Meghraoui-Kheddar , Sandrine Barthélémy , Alexandre Boissonnas , Christophe Combadière
Frontiers in Immunology, 2020, 11, pp.1117. ⟨10.3389/fimmu.2020.01117⟩
Article dans une revue hal-02898020v1
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Imaging resident and recruited macrophage contribution to Wallerian degeneration

Alexandre Boissonnas , Floriane Louboutin , Marie Laviron , Pierre-Louis Loyher , Elodie Reboussin
Journal of Experimental Medicine, 2020, 217 (11), ⟨10.1084/jem.20200471⟩
Article dans une revue hal-03047020v1
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Sepsis Triggers a Late Expansion of Functionally Impaired Tissue-Vascular Inflammatory Monocytes During Clinical Recovery

Camille Baudesson De Chanville , Benjamin Glenn Chousterman , Pauline Hamon , Marie Laviron , Noelline Guillou
Frontiers in Immunology, 2020, 11, pp.675. ⟨10.3389/fimmu.2020.00675⟩
Article dans une revue hal-02798381v1
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Ontogeny of Tumor-Associated Macrophages

Marie Laviron , Alexandre Boissonnas
Frontiers in Immunology, 2019, 10, pp.1799. ⟨10.3389/fimmu.2019.01799⟩
Article dans une revue hal-02279585v1
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Tracking Monocytes and Macrophages in Tumors With Live Imaging

Marie Laviron , Christophe Combadière , Alexandre Boissonnas
Frontiers in Immunology, 2019, 10, pp.1201. ⟨10.3389/fimmu.2019.01201⟩
Article dans une revue hal-02172263v1
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CCR2-Dependent Recruitment of Tregs and Monocytes Following Radiotherapy Is Associated with TNFα-Mediated Resistance

Michele Mondini , Pierre-Louis Loyher , Pauline Hamon , Marine Gerbé de Thoré , Marie Laviron
Cancer Immunology Research, 2019, 7 (3), pp.376-387. ⟨10.1158/2326-6066.CIR-18-0633⟩
Article dans une revue hal-02339936v1
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Macrophages of distinct origins contribute to tumor development in the lung

Pierre-Louis Loyher , Pauline Hamon , Marie Laviron , Aïda Meghraoui-Kheddar , Elena Goncalves
Journal of Experimental Medicine, 2018, 215 (10), pp.2536 - 2553. ⟨10.1084/jem.20180534⟩
Article dans une revue hal-01913815v1
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Unveiling Cerebral Leishmaniasis: parasites and brain inflammation in Leishmania donovani infected mice

Guilherme D. Melo , Sophie Goyard , Laurence Fiette , Alexandre Boissonnas , Christophe Combadiere
Scientific Reports, 2017, 7, pp.8454. ⟨10.1038/s41598-017-09085-5⟩
Article dans une revue hal-01581802v1

Macrophages Induce Long-Term Trapping of γδ T Cells with Innate-like Properties within Secondary Lymphoid Organs in the Steady State

Alexandra Audemard-Verger , Matthieu Rivière , Aurélie Durand , Elisa Peranzoni , Vincent Guichard
Journal of Immunology, 2017, 199 (6), pp.1998-2007. ⟨10.4049/jimmunol.1700430⟩
Article dans une revue hal-04003295v1
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Macrophages Induce Long-Term Trapping of γδ T Cells with Innate-like Properties within Secondary Lymphoid Organs in the Steady State

Alexandra Audemard-Verger , Matthieu Rivière , Aurélie Durand , Elisa Peranzoni , Vincent Guichard
Journal of Immunology, 2017, 199 (6), pp.1998-2007. ⟨10.4049/jimmunol.1700430⟩
Article dans une revue hal-03863963v1
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New insights into experimental visceral leishmaniasis: Real-time in vivo imaging of Leishmania donovani virulence

Guilherme Dias de Melo , Sophie Goyard , Hervé Lecoeur , Eline Rouault , Pascale Pescher
PLoS Neglected Tropical Diseases, 2017, 11 (9), pp.e0005924. ⟨10.1371/journal.pntd.0005924⟩
Article dans une revue hal-03504212v1

CX3CR1-dependent endothelial margination modulates Ly6Chigh monocyte systemic deployment upon inflammation in mice

Pauline Hamon , Pierre-Louis Loyher , Camille Baudesson de Chanville , Fabrice Licata , Christophe Combadière
Blood, 2017, 129 (10), pp.1296-1307. ⟨10.1182/blood-2016-08-732164⟩
Article dans une revue hal-04002521v1
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Calcineurin inhibitors impair neutrophil activity against Aspergillus fumigatus in allogenic hematopoietic stem cell transplant recipients

Sébastien Imbert , Priscillia Bresler , Alexandre Boissonnas , Lauraine Gauthier , Laëtitia Souchet
Journal of Allergy and Clinical Immunology, 2016, 138 (3), pp.860-868. ⟨10.1016/j.jaci.2016.02.026⟩
Article dans une revue hal-01301151v1
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CCR2 Influences T Regulatory Cell Migration to Tumors and Serves as a Biomarker of Cyclophosphamide Sensitivity

Pierre-Louis Loyher , Juliette Rochefort , Camille Baudesson de Chanville , Pauline Hamon , Géraldine Lescaille
Cancer Research, 2016, 76 (22), pp.6483 - 6494. ⟨10.1158/0008-5472.CAN-16-0984⟩
Article dans une revue hal-01397194v1

Ly6Chigh Monocytes Protect against Kidney Damage during Sepsis via a CX3CR1-Dependent Adhesion Mechanism

B. G. Chousterman , Alexandre Boissonnas , L. Poupel , C. Baudesson de Chanville , J. Adam
Journal of the American Society of Nephrology, 2016, 27 (3), pp.792-803 ⟨10.1681/ASN.2015010009⟩
Article dans une revue hal-01292451v1

Tracking Mouse Bone Marrow Monocytes In Vivo

Pauline Hamon , Mathieu P Rodero , Christophe Combadiere , Alexandre Boissonnas
Journal of visualized experiments : JoVE, 2015, 96, ⟨10.3791/52476⟩
Article dans une revue hal-02998291v1
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Immune surveillance of the lung by migrating tissue monocytes

Mathieu P Rodero , Lucie Poupel , Pierre-Louis Loyher , Pauline Hamon , Fabrice Licata
eLife, 2015, 4, pp.e07847. ⟨10.7554/eLife.07847⟩
Article dans une revue hal-01310477v1
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CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production

Ludovic Arnold , Hélène Perrin , Camille Baudesson de Chanville , Marielle Saclier , Patricia Hermand
Nature Communications, 2015, 6, pp.8972. ⟨10.1038/ncomms9972⟩
Article dans une revue hal-01514445v1

In vivo imaging reveals a pioneer wave of monocyte recruitment into mouse skin wounds

M.P. Rodero , F. Licata , L. Poupel , P. Hamon , K. Khosrotehrani
PLoS ONE, 2014, 9 (10), pp.e108212. ⟨10.1371/journal.pone.0108212⟩
Article dans une revue hal-01369479v1
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CD8+ Tumor-Infiltrating T Cells Are Trapped in the Tumor-Dendritic Cell Network

Alexandre Boissonnas , Fabrice Licata , Lucie Poupel , Sébastien Jacquelin , Luc Fetler
Neoplasia, 2013, 15 (1), pp.85. ⟨10.1593/neo.121572⟩
Article dans une revue hal-01586881v1

Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes.

Alexandre Boissonnas , Alix Scholer-Dahirel , Virginie Simon-Blancal , Luigia Pace , Fabien Valet
Immunity, 2010, 32 (2), pp.266-78. ⟨10.1016/j.immuni.2009.11.015⟩
Article dans une revue hal-00553080v1

In vivo cellular imaging of lymphocyte tracking by MRI: A tumor model approach to cell-based anticancer therapy

P. Smirnov , E. Lavergne , F. Gazeau , M. Lewin , A. Boissonnas
Magnetic Resonance in Medicine, 2006, 56(3), pp.498-508
Article dans une revue hal-00098654v1

In vivo cellular imaging of lymphocyte trafficking by MRI : a tumor model approach to cell-based anticancer therapy

Pierre Smirnov , Elise Lavergne , Florence Gazeau , Maïté Lewin , Alexandre Boissonnas
Magnetic Resonance in Medicine, 2006, 56 (3), pp.498-508. ⟨10.1002/mrm.20996⟩
Article dans une revue hal-00348207v1