Alexia Chauzy

36
Documents

Publications

Publications

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A freely accessible, adaptable hollow-fiber setup to reproduce first-order absorption: illustration with linezolid cerebrospinal fluid pharmacokinetic data

Noémie Prébonnaud , Alexia Chauzy , Nicolas Grégoire , Claire Dahyot-Fizelier , Christophe Adier et al.

Microbiology Spectrum, 2025, ⟨10.1128/spectrum.00051-25⟩

Article dans une revue hal-05085650v1

<i>In vitro</i> pharmacokinetic/pharmacodynamic modeling of the effect of mucin on polymyxin B activity against <i>Acinetobacter baumannii</i>

Mathilde Lacroix , Jérémy Moreau , Claudia Zampaloni , Caterina Bissantz , Hélène Mirfendereski et al.

Antimicrobial Agents and Chemotherapy, 2025, 69 (5), pp.112076. ⟨10.1128/aac.01535-24⟩

Article dans une revue hal-05144888v1
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PKPD modeling of the inoculum effect of combined ceftazidime/avibactam and colistin against KPC-3 Klebsiella pneumoniae isolate

Romain Aubry , Julien Buyck , Alexia Chauzy , Laure Prouvensier , Jean-Winoc Decousser et al.

Antimicrobial Agents and Chemotherapy, 2025, 69 (5), ⟨10.1128/aac.01797-24⟩

Article dans une revue hal-05153931v1
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A hollow fiber infection model to study intracellular and extracellular antibiotic activity against Staphylococcus aureus

Gwenaëlle Mahieu , Laure Elens , Noémie Prébonnaud , Alexia Chauzy , Françoise van Bambeke

iScience, 2025, 28 (3), pp.112076. ⟨10.1016/j.isci.2025.112076⟩

Article dans une revue hal-05136030v1
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Impact of nutritional factors on in vitro PK/PD modelling of polymyxin B against various strains of Acinetobacter baumannii

Mathilde Lacroix , Jérémy Moreau , Claudia Zampaloni , Caterina Bissantz , Hamasseh Shirvani et al.

International Journal of Antimicrobial Agents, 2024, 64 (1), pp.107189. ⟨10.1016/j.ijantimicag.2024.107189⟩

Article dans une revue hal-04643050v1
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Targeting lung macrophages for fungal and parasitic pulmonary infections with innovative amphotericin B dry powder inhalers

E. de Pablo , P. O'Connell , R. Fernández-García , S. Marchand , A. Chauzy et al.

International Journal of Pharmaceutics, 2023, 635, pp.122788. ⟨10.1016/j.ijpharm.2023.122788⟩

Article dans une revue hal-04131635v1
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A New Pharmacokinetic-Pharmacodynamic Model To Characterize the Inoculum Effect of Acinetobacter baumannii on Polymyxin B In Vitro

Grace Akrong , Alexia Chauzy , Vincent Aranzana-Climent , Mathilde Lacroix , Luc Deroche et al.

Antimicrobial Agents and Chemotherapy, 2022, 66 (1), pp.e0178921. ⟨10.1128/AAC.01789-21⟩

Article dans une revue hal-03615758v1
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PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo

Alexia Chauzy , Grace Akrong , Vincent Aranzana-Climent , Jérémy Moreau , Laure Prouvensier et al.

Frontiers in Pharmacology, 2022, 13, pp.842921. ⟨10.3389/fphar.2022.842921⟩

Article dans une revue hal-03615739v1
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Improved In Vitro Anti-Mucorales Activity and Cytotoxicity of Amphotericin B with a Pegylated Surfactant

Kévin Brunet , Cheikh Diop , Alexia Chauzy , Noémie Prébonnaud , Sandrine Marchand et al.

Journal of Fungi, 2022, 8 (2), pp.121. ⟨10.3390/jof8020121⟩

Article dans une revue hal-03615762v1
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A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients

Alexia Chauzy , Salim Bouchène , Vincent Aranzana-Climent , Jonathan Clarhaut , Christophe Adier et al.

Antibiotics, 2022, 11 (10), pp.1293. ⟨10.3390/antibiotics11101293⟩

Article dans une revue hal-03906712v1
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Population pharmacokinetic/pharmacodynamic study suggests continuous infusion of ceftaroline daily dose in ventilated critical care patients with early-onset pneumonia and augmented renal clearance

Alexia Chauzy , Nicolas Grégoire , Martine Ferrandière , Sigismond Lasocki , Karim Ashenoune et al.

Journal of Antimicrobial Chemotherapy, 2022, 77 (11), pp.3173-3179. ⟨10.1093/jac/dkac299⟩

Article dans une revue hal-03906736v1
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Clinical Pharmacokinetics of Daptomycin

Nicolas Grégoire , Alexia Chauzy , Julien Buyck , Blandine Rammaert , William Couet et al.

Clinical Pharmacokinetics, 2020, ⟨10.1007/s40262-020-00968-x⟩

Article dans une revue hal-03071620v1

Sequential time-kill: a simple experimental trick to discriminate between PK/PD models with distinct heterogeneous sub-populations versus homogenous population with adaptive resistance

Alexia Chauzy , H Ih , M Jacobs , S Marchand , N Grégoire et al.

Antimicrobial Agents and Chemotherapy, 2020, ⟨10.1128/AAC.00788-20⟩

Article dans une revue hal-02888859v1
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Pharmacodynamic modelling of β-lactam/β-lactamase inhibitor checkerboard data: illustration with aztreonam–avibactam

Alexia Chauzy , Julien Buyck , B.L.M. de Jonge , Sandrine Marchand , N. Grégoire et al.

Clinical Microbiology and Infection, 2019, 25 (4), pp.515.e1-515.e4. ⟨10.1016/j.cmi.2018.11.025⟩

Article dans une revue hal-02321069v1
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Semimechanistic Pharmacodynamic Modeling of Aztreonam‐Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug‐Resistant Gram‐Negative Bacteria

Alexia Chauzy , Bruna Gaelzer Silva Torres , Julien Buyck , Boudewijn Jonge , Christophe Adier et al.

CPT: Pharmacometrics and Systems Pharmacology, 2019, ⟨10.1002/psp4.12452⟩

Article dans une revue hal-02320523v1

Cerebrospinal fluid pharmacokinetics of ceftaroline in neurosurgical patients with an external ventricular drain

Alexia Chauzy , Abdelouaïd Nadji , Jean-Christophe Combes , Nadine Defrance , Belaid Bouhemad et al.

Journal of Antimicrobial Chemotherapy, 2019, 74 (3), pp.675-681. ⟨10.1093/jac/dky489⟩

Article dans une revue hal-01957116v1
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Microdialysis Study of Aztreonam-Avibactam Distribution in Peritoneal Fluid and Muscle of Rats with or without Experimental Peritonitis

Alexia Chauzy , Isabelle Lamarche , Christophe Adier , William Couet , Sandrine Marchand

Antimicrobial Agents and Chemotherapy, 2018, 62 (10), ⟨10.1128/AAC.01228-18⟩

Article dans une revue hal-02321070v1

Microdialysis as a way to measure antibiotics concentration in tissues

Sandrine Marchand , Alexia Chauzy , Claire Dahyot-Fizelier , William Couet

Pharmacological Research, 2016, 111, pp.201-207. ⟨10.1016/j.phrs.2016.06.001⟩

Article dans une revue istex hal-02321071v1
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Simulation-based prediction of pharmacokinetic/pharmacodynamic (PK/PD) index for linezolid to treat cerebral infections in critically ill patients

Michael Burtin , Noémie Prébonnaud , Sandrine Marchand , Nicolas Grégoire , Claire Dahyot-Fizelier et al.

33rd PAGE meeting, Jun 2025, Thessalokini, Greece.

Poster de conférence hal-05240779v1
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In vitro evaluation of the inoculum effect of various β-lactamase-producing Klebsiella pneumoniae isolates on ceftazidime-avibactam

Alexia Chauzy , William Couet , Isabelle Martin , Hélène Mirfendereski , Sandrine Marchand

34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain

Poster de conférence hal-04571024v1
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Impact of in vitro use of artificial cerebrospinal fluid compared to Mueller-Hinton broth on the efficacy of linezolid against Staphylococcus aureus in a hollow-fiber model

Noémie Prébonnaud , Alexia Chauzy , Christophe Adier , Isabelle Martin , Claire Dahyot-Fizelier et al.

34th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2024, Barcelona, Spain

Poster de conférence hal-04571091v1
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PK/PD modelling of the CAMHB nutrients concentrations effect on polymyxin B antimicrobial activity against Acinetobacter baumannii

Mathilde Lacroix , Jérémy Moreau , Claudia Zampaloni , Caterina Bissantz , Hamasseh Shirvani et al.

33rd ECCMID : European Congress of Clinical Microbiology & Infectious Diseases, Apr 2023, Copenaghen, Denmark

Poster de conférence hal-04141371v1
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Comparison between pharmacokinetic-phramcodynamic modeling results of ceftaroline against methicillin-resistant Staphylococcus aureus after Time Kill and Hollow Fiber experiments

Alexia Chauzy , Arthur Fourmy , Hélène Mirfendereski , William Couet , Sandrine Marchand

32nd ECCMID, Apr 2022, Lisbonne, Portugal

Poster de conférence hal-04014948v1
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In vitro PK/PD modelling of polymyxin B against resistant strain of A. baumannii in presence of mucin

Mathilde Lacroix , Alexia Chauzy , Claudia Zampaloni , Caterina Bissantz , Hélène Mirfendereski et al.

32nd ECCMID, Apr 2022, Lisabon, Portugal

Poster de conférence hal-04016532v1
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A minimal physiologically-based pharmacokinetic model to investigate CNS distribution of metronidazole in ICU patients

Alexia Chauzy , Salim Bouchène , Nicolas Grégoire , William Couet , Olivier Mimoz et al.

39ème Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse (RICAI), Dec 2019, Paris, France

Poster de conférence hal-02528416v1
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Semi-mechanistic pharmacodynamics modeling of aztreonam- avibactam combination to understand its antimicrobial activity against multidrug-resistant Gram(-) bacteria

Alexia Chauzy , Bruna Gaelzer Silva Torres , Julien Buyck , Boudewijn Jonge , Christophe Adier et al.

PAGE meeting, Jun 2019, Stockholm, Sweden

Poster de conférence hal-02528382v1
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Semi-mechanistic pharmacokinetic/pharmacodynamics modeling of aztreonam-avibactam combination against multidrug resistant Gram(-) organisms

Alexia Chauzy , Bruna Gaelzer Silva Torres , Julien Buyck , Emma Marquizeau , Patrice Gobin et al.

the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2018, Madrid, Spain

Poster de conférence hal-02528294v1
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Cerebrospinal fluid pharmacokinetics of ceftaroline in neurosurgical patients with external ventricular drain

Pascal Chavanet , Alexia Chauzy , Nadine Defrance , Abdelouaïd Nadji , Jean-Christophe Combes et al.

the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2018, Madrid, Spain

Poster de conférence hal-02528340v1
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Microdialysis study distribution of aztreonam and avibactam in skeletal muscle and intraperitoneal fluid of rats with or without experimental peritonitis

Alexia Chauzy , Nicolas Grégoire , Isabelle Lamarche , Patrice Gobin , William Couet et al.

the 27th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2017, Vienne, Austria

Poster de conférence hal-02512109v1
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Appraisal of potential effect of subcutaneous administration on antibiotics pharmacokinetics-pharmacodynamics

Alexia Chauzy , Nicolas Grégoire , Sandrine Marchand , Olivier Mimoz , Marc Paccalin et al.

the 25th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), Apr 2015, Copenhague, Denmark

Poster de conférence hal-02512083v1