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AMEL BAHLOUL

21
Documents

Publications

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Current Advances in Gene Therapies of Genetic Auditory Neuropathy Spectrum Disorder

Anissa Rym Saidia , Jérôme Ruel , Amel Bahloul , Benjamin Chaix , Frédéric Venail
Journal of Clinical Medicine, 2023, 12 (3), pp.738. ⟨10.3390/jcm12030738⟩
Article dans une revue hal-04311297v1
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Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells

Vincent Michel , Elise Pepermans , Jacques Boutet de Monvel , Patrick England , Sylvie Nouaille
Scientific Reports, 2020, 10 (1), pp.16430. ⟨10.1038/s41598-020-73158-1⟩
Article dans une revue hal-02988089v1

Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis

Sophie Boucher , Fabienne Wong Jun Tai , Sedigheh Delmaghani , Andrea Lelli , Amrit Singh-Estivalet
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (49), pp.31278-31289. ⟨10.1073/pnas.2010782117⟩
Article dans une revue pasteur-03215054v1
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Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners

Yanlei Zhu , Florent Delhommel , Florence Cordier , Susanne Lüchow , Ariel E Mechaly
Journal of Molecular Biology, 2020, 432 (22), pp.5920 - 5937. ⟨10.1016/j.jmb.2020.09.012⟩
Article dans une revue hal-02990253v1
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A Novel Heterozygous Missense Variant (c.667G>T;p.Gly223Cys) in USH1C That Interferes With Cadherin-Related 23 and Harmonin Interaction Causes Autosomal Dominant Nonsyndromic Hearing Loss

Ju Sun Song , Amel Bahloul , Christine Petit , Sang Jin Kim , Il Joon Moon
Annals of Laboratory Medicine, 2020, 40 (3), pp.224-231. ⟨10.3343/alm.2020.40.3.224⟩
Article dans une revue hal-02433812v1
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CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival

Vincent Michel , Kevin T Booth , Pranav Patni , Matteo Cortese , Hela Azaiez
EMBO Molecular Medicine, 2017, 9 (12), pp.1711 - 1731. ⟨10.15252/emmm.201708087⟩
Article dans une revue hal-01661175v1

Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem

Florent Delhommel , Florence Cordier , Benjamin Bardiaux , Guillaume Bouvier , Baptiste Colcombet-Cazenave
Structure, 2017, 25 (11), pp.1645-1656.e5. ⟨10.1016/j.str.2017.08.013⟩
Article dans une revue pasteur-02883914v1
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Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses

Nicolas Michalski , Juan D Goutman , Sarah Marie Auclair , Jacques Boutet de Monvel , Margot Tertrais
eLife, 2017, 6, pp.e31013. ⟨10.7554/eLife.31013⟩
Article dans une revue hal-01665122v1
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Conformational switch of harmonin, a submembrane scaffold protein of the hair cell mechanoelectrical transduction machinery

Amel Bahloul , Elise Pepermans , Bertrand Raynal , Nicolas Wolff , Florence Cordier
FEBS Letters, 2017, 591 (15), pp.2299 - 2310. ⟨10.1002/1873-3468.12729⟩
Article dans une revue pasteur-01858477v1
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Diversity of the Genes Implicated in Algerian Patients Affected by Usher Syndrome

Samia Abdi , Amel Bahloul , Asma Behlouli , Jean-Pierre Hardelin , Mohamed Makrelouf
PLoS ONE, 2016, 11 (9), pp.e0161893. ⟨10.1371/journal.pone.0161893⟩
Article dans une revue hal-01388303v1
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The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells

Elise Pepermans , Michel Vittot , Richard Goodyear , Crystel Bonnet , Samia Abdi
EMBO Molecular Medicine, 2014, 6 (7), pp.984-92. ⟨10.15252/emmm.201403976⟩
Article dans une revue pasteur-01237053v1
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Localization of Usher 1 proteins to the photoreceptor calyceal processes, which are absent from mice.

Iman Sahly , Eric Dufour , Cataldo Schietroma , Vincent Michel , Amel Bahloul
Journal of Cell Biology, 2012, 199 (2), pp.381-99. ⟨10.1083/jcb.201202012⟩
Article dans une revue inserm-00743698v1
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Crystal Structure of Two Anti-Porphyrin Antibodies with Peroxidase Activity

Victor Muñoz Robles , Jean-Didier Maréchal , Amel Bahloul , Marie-Agnès Sari , Jean-Pierre Mahy
PLoS ONE, 2012, 7 (12), pp.e51128. ⟨10.1371/journal.pone.0051128⟩
Article dans une revue hal-03280278v1
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Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia.

Elisa Caberlotto , Michel Vittot , Isabelle Foucher , Amel Bahloul , Richard J Goodyear
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (14), pp.5825-30. ⟨10.1073/pnas.1017114108⟩
Article dans une revue pasteur-01472844v1
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Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids

Amel Bahloul , Vincent Michel , Jean-Pierre Hardelin , Sylvie Nouaille , Sylviane Hoos
Human Molecular Genetics, 2010, 19 (18), pp.3557 - 3565. ⟨10.1093/hmg/ddq271⟩
Article dans une revue pasteur-03525648v1

Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses

Isabelle Roux , Suzanne Hosie , Stuart Johnson , Amel Bahloul , Nadège Cayet
Human Molecular Genetics, 2009, 18 (23), pp.4615-4628. ⟨10.1093/hmg/ddp429⟩
Article dans une revue hal-04159601v1

Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells

Amel Bahloul , Marie‐christine Simmler , Vincent Michel , Michel Leibovici , Isabelle Perfettini
EMBO Molecular Medicine, 2009, 1 (2), pp.125-138. ⟨10.1002/emmm.200900015⟩
Article dans une revue hal-04267061v1

Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells.

Amel Bahloul , Marie-Christine Simmler , Vincent Michel , Michel Leibovici , Isabelle Perfettini
EMBO Molecular Medicine, 2009, 1 (2), pp.125-38. ⟨10.1002/emmm.200900015⟩
Article dans une revue hal-00477439v1

Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse.

Isabelle Roux , Saaid Safieddine , Régis Nouvian , M'Hamed Grati , Marie-Christine Simmler
Cell, 2006, 127 (2), pp.277-89. ⟨10.1016/j.cell.2006.08.040⟩
Article dans une revue hal-00111976v1

Electrospray ionization mass spectrometry studies of noncovalent myosin VI complexes reveal a new specific calmodulin binding site

Guillaume Chevreux , Noelle Potier , Alain Dorsselaer , Amel Bahloul , Anne Houdusse
Journal of The American Society for Mass Spectrometry, 2005, 16 (8), pp.1367-1376. ⟨10.1016/j.jasms.2005.03.023⟩
Article dans une revue hal-02981194v1
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PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa.

Raphael Etournay , Aziz El-Amraoui , Amel Bahloul , Stéphane Blanchard , Isabelle Roux
Journal of Cell Science, 2005, 118 (13), pp.2891-99. ⟨10.1242/jcs.02424⟩
Article dans une revue pasteur-01541848v1