AP

André Pèlegrin

81%
Libre accès
85
Documents
Contact

Présentation


Publications

Publications

Image document

Design and selection of optimal ErbB-targeting bispecific antibodies in pancreatic cancer

Emilia Rabia , Véronique Garambois , Christine Dhommée , Christel Larbouret , Laurie Lajoie et al.
Frontiers in Immunology, 2023, 14, ⟨10.3389/fimmu.2023.1168444⟩
Article dans une revue hal-04102843 v2
Image document

Carcinoembryonic Antigen–Related Cell Adhesion Molecule Type 5 Receptor–Targeted Fluorescent Intraoperative Molecular Imaging Tracer for Lung Cancer

Feredun Azari , Ruben P J Meijer , Gregory T Kennedy , Andrew Hanna , Ashley Chang et al.
JAMA Network Open, 2023, 6 (1), pp.e2252885. ⟨10.1001/jamanetworkopen.2022.52885⟩
Article dans une revue hal-04588970 v1
Image document

Improving Biologics’ Effectiveness in Clinical Oncology: From the Combination of Two Monoclonal Antibodies to Oligoclonal Antibody Mixtures

Christel Larbouret , Laurent Gros , André Pèlegrin , Thierry Chardès
Cancers, 2021, 13 (18), pp.4620. ⟨10.3390/cancers13184620⟩
Article dans une revue hal-03360265 v1
Image document

Anti-tumoral activity of the Pan-HER (Sym013) antibody mixture in gemcitabine-resistant pancreatic cancer models

Emilia Rabia , Véronique Garambois , Julie Hubert , Marine Bruciamacchie , Nelly Pirot et al.
mAbs, 2021, 13 (1), pp.1914883. ⟨10.1080/19420862.2021.1914883⟩
Article dans une revue hal-03360283 v1
Image document

Anti-Müllerian hormone concentration regulates activin receptor-like kinase-2/3 expression levels with opposing effects on ovarian cancer cell survival

Maëva Chauvin , Veronique Garambois , Sylvie Choblet , Pierre-Emmanuel Colombo , Myriam Chentouf et al.
International Journal of Oncology, 2021, 59 (1), ⟨10.3892/ijo.2021.5223⟩
Article dans une revue hal-03367210 v1
Image document

Anti-Müllerian hormone (AMH) autocrine signaling promotes survival and proliferation of ovarian cancer cells

Maëva Chauvin , Véronique Garambois , Pierre-Emmanuel Colombo , Myriam Chentouf , Laurent Gros et al.
Scientific Reports, 2021, 11, pp.2231. ⟨10.1038/s41598-021-81819-y⟩
Article dans une revue hal-03131997 v1

Multimodal CEA-Targeted Image-Guided Colorectal Cancer Surgery using 111In-Labeled SGM-101

Jan Marie de Gooyer , Fortuné M.K. Elekonawo , Desirée Bos , Rachel van der Post , André Pèlegrin et al.
Clinical Cancer Research, 2020, 26 (22), pp.5934-5942. ⟨10.1158/1078-0432.CCR-20-2255⟩
Article dans une revue hal-05068748 v1
Image document

Biasing HER4 tyrosine kinase signaling with antibodies: Induction of cell death by antibody‐dependent HER4 intracellular domain trafficking

Romain Lanotte , Véronique Garambois , Nadège Gaborit , Christel Larbouret , Astrid Musnier et al.
Cancer Science, 2020, 111 (7), pp.2508-2525. ⟨10.1111/cas.14458⟩
Article dans une revue hal-03036389 v1
Image document

Quantification of HER1, HER2 and HER3 by time-resolved Förster resonance energy transfer in FFPE triple-negative breast cancer samples

Alexandre Ho-Pun-Cheung , Hervé Bazin , Florence Boissière-Michot , Caroline Mollevi , Joëlle Simony-Lafontaine et al.
British Journal of Cancer, 2020, 122 (3), pp.397-404. ⟨10.1038/s41416-019-0670-8⟩
Article dans une revue hal-03037393 v1
Image document

Higher Anti-Tumor Efficacy of the Dual HER3-EGFR Antibody MEHD7945a Combined with Ionizing Irradiation in Cervical Cancer Cells

Laura Bourillon , Sylvain Demontoy , Alexis Lenglet , Alexandre Zampieri , Julien Fraisse et al.
International Journal of Radiation Oncology, Biology, Physics, 2020, 106 (5), pp.1039-1051. ⟨10.1016/j.ijrobp.2019.12.020⟩
Article dans une revue hal-03038992 v1
Image document

Toxicity and pharmacokinetic profile of SGM-101, a fluorescent anti-CEA chimeric antibody for fluorescence imaging of tumors in patients

Bérénice Framery , Marian Gutowski , Karen Dumas , Alexandre Evrard , Nathalie Muller et al.
Toxicology Reports, 2019, 6, pp.409--415. ⟨10.1016/j.toxrep.2019.04.011⟩
Article dans une revue hal-02931825 v1
Image document

A recycling anti-transferrin receptor-1 monoclonal antibody as an efficient therapy for erythroleukemia through target up-regulation and antibody-dependent cytotoxic effector functions

Madeline Neiveyans , Rana Melhem , Christophe Arnoult , Thomas Bourquard , Marta Jarlier et al.
mAbs, 2019, 11 (3), pp.593-605. ⟨10.1080/19420862.2018.1564510⟩
Article dans une revue hal-02325764 v1
Image document

ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells

Christophe Le Clorennec , Yassamine Lazrek , Olivier Dubreuil , Carla Sampaio , Christel Larbouret et al.
Cell Communication and Signaling, 2019, 17 (1), pp.106-122. ⟨10.1186/s12964-019-0413-8⟩
Article dans une revue inserm-02280785 v1
Image document

An auristatin‐based antibody‐drug conjugate targeting HER3 enhances the radiation response in pancreatic cancer

Laura Bourillon , Céline Bourgier , Nadège Gaborit , Véronique Garambois , Eva Lles et al.
International Journal of Cancer, 2019, 145 (7), pp.1838-1851. ⟨10.1002/ijc.32273⟩
Article dans une revue inserm-02074060 v1
Image document

Quantitative proteomic analysis reveals AK2 as potential biomarker for late normal tissue radiotoxicity

Jérôme Lacombe , Muriel Brengues , Alain Mangé , Céline Bourgier , Sophie Gourgou et al.
Radiation Oncology, 2019, 14 (1), pp.142. ⟨10.1186/s13014-019-1351-8⟩
Article dans une revue hal-02371868 v1

Targets for MAbs: innovative approaches for their discovery & validation, LabEx MAbImprove 6 th antibody industrial symposium, June 25-26, 2018, Montpellier, France

Pierre Martineau , Herve Watier , André Pèlegrin , Andrei Turtoi
mAbs, 2019, 11 (5), pp.812-825. ⟨10.1080/19420862.2019.1612691⟩
Article dans une revue hal-02448613 v1

Image-Guided Surgery in Patients with Pancreatic Cancer: First Results of a Clinical Trial Using SGM-101, a Novel Carcinoembryonic Antigen-Targeting, Near-Infrared Fluorescent Agent

Charlotte Hoogstins , Leonora Boogerd , Babs Sibinga Mulder , J. Sven D. Mieog , Rutger Jan Swijnenburg et al.
Annals of Surgical Oncology, 2018, 25 (11), pp.3350-3357. ⟨10.1245/s10434-018-6655-7⟩
Article dans une revue hal-02289226 v1

Safety and effectiveness of SGM-101, a fluorescent antibody targeting carcinoembryonic antigen, for intraoperative detection of colorectal cancer: a dose-escalation pilot study

Leonora Boogerd , Charlotte Hoogstins , Dennis Schaap , Miranda Kusters , Henricus Handgraaf et al.
The Lancet Gastroenterology & Hepatology, 2018, 3 (3), pp.181-191. ⟨10.1016/S2468-1253(17)30395-3⟩
Article dans une revue hal-02284980 v1
Image document

Targeting the NRG1/HER3 pathway in tumor cells and cancer-associated fibroblasts with an anti-neuregulin 1 antibody inhibits tumor growth in pre-clinical models of pancreatic cancer

Charline Ogier , Pierre-Emmanuel Colombo , Corinne Bousquet , Lucile Canterel-Thouennon , Pierre Sicard et al.
Cancer Letters, 2018, 432, pp.227-236. ⟨10.1016/j.canlet.2018.06.023⟩
Article dans une revue hal-02350723 v1

Antibody-drug conjugates: Design and development for therapy and imaging in and beyond cancer, LabEx MAbImprove industrial workshop, July 27–28, 2017, Tours, France

Camille Martin , Claire Kizlik-Masson , André Pèlegrin , Hervé Watier , Marie-Claude Viaud-Massuard et al.
mAbs, 2018, 10 (2), pp.210-221. ⟨10.1080/19420862.2017.1412130⟩
Article dans une revue hal-02290096 v1
Image document

The humanized anti-human AMHRII mAb 3C23K exerts an anti-tumor activity against human ovarian cancer through tumor-associated macrophages

Houcine Bougherara , Fariba Nemati , André Nicolas , Gérald Massonnet , Martine Pugnière et al.
Oncotarget, 2017, 8 (59), pp.99950-99965. ⟨10.18632/oncotarget.21556⟩
Article dans une revue hal-02382914 v1

Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis

Nina Radosevic-Robin , Wilhem Leconet , Myriam Chentouf , Stanislas Du Manoir , Clément Chevalier et al.
Clinical Cancer Research, 2017, 23 (11), pp.2806 - 2816. ⟨10.1158/1078-0432.CCR-16-1316⟩
Article dans une revue hal-01676378 v1

SGM-101: An innovative near-infrared dye-antibody conjugate that targets CEA for fluorescence-guided surgery

Marian Gutowski , Bérénice Framery , Martin Boonstra , Véronique Garambois , François Quenet et al.
Surgical Oncology, 2017, 26 (2), pp.153-162. ⟨10.1016/j.suronc.2017.03.002⟩
Article dans une revue hal-02371819 v1
Image document

Neuregulin 1 Allosterically Enhances the Antitumor Effects of the Noncompeting Anti-HER3 Antibody 9F7-F11 by Increasing Its Binding to HER3

Christophe Le Clorennec , Hervé Bazin , Olivier Dubreuil , Christel Larbouret , Charline Ogier et al.
Molecular Cancer Therapeutics, 2017, 16 (7), pp.1312-1323. ⟨10.1158/1535-7163.MCT-16-0886⟩
Article dans une revue hal-02434070 v1
Image document

The anti-tumor efficacy of 3C23K, a glyco-engineered humanized anti-MISRII antibody, in an ovarian cancer model is mainly mediated by engagement of immune effector cells

Pauline Estupina , Alexandre Fontayne , Jean-Marc Barret , Nathalie Kersual , Olivier Dubreuil et al.
Oncotarget, 2017, 8 (23), pp.37061-37079. ⟨10.18632/oncotarget.15715⟩
Article dans une revue hal-02379710 v1
Image document

Pregnane X-receptor promotes stem cell-mediated colon cancer relapse

Chris Planque , Fatemeh Rajabi , Fanny Grillet , Pascal Finetti , François Bertucci et al.
Oncotarget, 2016, 7 (35), pp.56558-56573. ⟨10.18632/oncotarget.10646⟩
Article dans une revue hal-01431926 v1

Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells

Julie Giraud , Laura Failla , Jean-Marc Pascussi , Ebba Louise Lagerqvist , Jérémy Ollier et al.
Cancer Research, 2016, 76 (12), pp.3618 - 3628. ⟨10.1158/0008-5472.CAN-15-1497⟩
Article dans une revue hal-01905320 v1
Image document

The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation

Christophe Le Clorennec , Yassamine Lazrek , Olivier Dubreuil , Christel Larbouret , Marie-Alix Poul et al.
Oncotarget, 2016, 7 (24), pp.37013-37029. ⟨10.18632/oncotarget.9455⟩
Article dans une revue hal-02297403 v1

T lymphocytes to predict radiation-induced late effects in normal tissues

Muriel Brengues , Ariane Lapierre , Céline Bourgier , André Pèlegrin , David Azria
Expert Review of Molecular Diagnostics, 2016, 17 (2), pp.119-127. ⟨10.1080/14737159.2017.1271715⟩
Article dans une revue hal-02376569 v1

Concurrent or sequential letrozole with adjuvant breast radiotherapy: final results of the CO-HO-RT phase II randomized trial

C. Bourgier , S. Kerns , S. Gourgou , C. Lemanski , M. Gutowski et al.
Annals of Oncology, 2016, 27 (3), pp.474-480. ⟨10.1093/annonc/mdv602⟩
Article dans une revue hal-02338912 v1
Image document

Dual targeting of HER1/EGFR and HER2 with cetuximab and trastuzumab in patients with metastatic pancreatic cancer after gemcitabine failure: results of the "THERAPY"phase 1-2 trial

Eric Assenat , David Azria , Caroline Mollevi , Rosine Guimbaud , Nicole Tubiana-Mathieu et al.
Oncotarget, 2015, 6 (14), ⟨10.18632/oncotarget.3473⟩
Article dans une revue hal-02005981 v1
Image document

Examination of HER3 targeting in cancer using monoclonal antibodies

Nadège Gaborit , Ali Abdul-Hai , Maicol Mancini , Moshit Lindzen , Sara Lavi et al.
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (3), pp.839-844. ⟨10.1073/pnas.1423645112⟩
Article dans une revue hal-02276327 v1
Image document

The HER3/ERBB3 receptor: the dark side of the ERBB planet

Christel Larbouret , Nadège Gaborit , Marie-Alix Poul , André Pèlegrin , Thierry Chardès
Médecine/Sciences, 2015, 31 (5), pp.465-468. ⟨10.1051/medsci/20153105002⟩
Article dans une revue hal-02285139 v1

Neutralization of KIT Oncogenic Signaling in Leukemia with Antibodies Targeting KIT Membrane Proximal Domain 5

M. Le Gall , R. Crepin , M. Neiveyans , C. C. Auclair , Y. Fan et al.
Molecular Cancer Therapeutics, 2015, 14 (11), pp.2595-2605. ⟨10.1158/1535-7163.MCT-15-0321⟩
Article dans une revue hal-02329816 v1
Image document

Radiation-induced CD8 T-lymphocyte Apoptosis as a Predictor of Breast Fibrosis After Radiotherapy: Results of the Prospective Multicenter French Trial

David Azria , Olivier Riou , Florence Castan , Tan Dat Nguyen , Karine Peignaux et al.
EBioMedicine, 2015, 2 (12), pp.1965-1973. ⟨10.1016/j.ebiom.2015.10.024⟩
Article dans une revue hal-02338826 v1

Late side-effects after curative intent radiotherapy: Identification of hypersensitive patients for personalized strategy

Céline Bourgier , Jérôme Lacombe , Jérôme Solassol , Alain Mangé , André Pèlegrin et al.
Critical Reviews in Oncology/Hematology, 2015, 93 (3), pp.312-319. ⟨10.1016/j.critrevonc.2014.11.004⟩
Article dans une revue hal-02148578 v1
Image document

Preclinical validation of AXL receptor as a target for antibody-based pancreatic cancer immunotherapy.

Wilhem Leconet , Christel Larbouret , Thierry Chardès , Gaëlle Thomas , Madeline Neiveyans et al.
Oncogene, 2014, 33 (47), pp.5405-14. ⟨10.1038/onc.2013.487⟩
Article dans une revue inserm-00916587 v1
Image document

HER3 as biomarker and therapeutic target in pancreatic cancer: new insights in pertuzumab therapy in preclinical models

Gaëlle Thomas , Thierry Chardès , Nadège Gaborit , Caroline Mollevi , Wilhem Leconet et al.
Oncotarget, 2014, 5 (16), pp.7138-7148. ⟨10.18632/oncotarget.2231⟩
Article dans une revue hal-02387994 v2

MAbImprove: a French "Laboratoire d'excellence" (LabEx) dedicated to therapeutic antibodies

Andre Pelegrin , A. Daguet , H. Watier
mAbs, 2014, 6, pp.803--4. ⟨10.4161/mabs.29262⟩
Article dans une revue hal-02168048 v1
Image document

The human Mullerian inhibiting substance type II receptor as immunotherapy target for ovarian cancer. Validation using the mAb 12G4

Nathalie Kersual , Véronique Garambois , Thierry Chardès , Jean-Pierre Pouget , Imed Salhi et al.
mAbs, 2014, 6, pp.1314--26. ⟨10.4161/mabs.29316⟩
Article dans une revue hal-02168055 v1
Image document

DNA damage-centered signaling pathways are effectively activated during low dose-rate Auger radioimmunotherapy.

Bérengère Piron , Salomé Paillas , Vincent Boudousq , André Pèlegrin , Caroline Bascoul-Mollevi et al.
Nuclear Medicine and Biology, 2014, 41 Suppl, pp.e75-83. ⟨10.1016/j.nucmedbio.2014.01.012⟩
Article dans une revue inserm-00981411 v1
Image document

Peptides in Receptor-Mediated Radiotherapy: From Design to the Clinical Application in Cancers

Catherine Lozza , Isabelle Navarro-Teulon , André Pèlegrin , Jean-Pierre Pouget , Eric Vivès
Frontiers in Oncology, 2013, 3 (2), pp.332. ⟨10.3389/fonc.2013.00247⟩
Article dans une revue hal-03824440 v1
Image document

Comparison between Internalizing Anti-HER2 mAbs and Non-Internalizing Anti-CEA mAbs in Alpha-Radioimmunotherapy of Small Volume Peritoneal Carcinomatosis Using (2) (1) (2)Pb.

Vincent Boudousq , Laure Bobyk , Muriel Busson , Véronique Garambois , Marta Jarlier et al.
PLoS ONE, 2013, 8 (7), pp.e69613. ⟨10.1371/journal.pone.0069613⟩
Article dans une revue inserm-00853390 v1
Image document

Anti-HER3 domain 1 and 3 antibodies reduce tumor growth by hindering HER2/HER3 dimerization and AKT-induced MDM2, XIAP, and FoxO1 phosphorylation.

Yassamine Lazrek , Olivier Dubreuil , Véronique Garambois , Nadège Gaborit , Christel Larbouret et al.
Neoplasia, 2013, 15 (3), pp.335-47. ⟨10.1593/neo.121960⟩
Article dans une revue inserm-00815985 v1

Radiosensibilité individuelle : les tests vont changer nos pratiques

J. Lacombe , O. Riou , J. Solassol , Alain Mangé , C. Bourgier et al.
Cancer/Radiothérapie, 2013, 17 (5-6), pp.337-343. ⟨10.1016/j.canrad.2013.07.137⟩
Article dans une revue istex hal-02372002 v1
Image document

Apoptosis and p53 are not involved in the anti-tumor efficacy of (125)I-labeled monoclonal antibodies targeting the cell membrane.

Salomé Paillas , Laurent Boudou , Bérengère Piron , Nathalie Kersual , Manuel Bardiès et al.
Nuclear Medicine and Biology, 2013, epub ahead of print. ⟨10.1016/j.nucmedbio.2013.02.001⟩
Article dans une revue inserm-00815724 v1
Image document

Single-domain antibody-based and linker-free bispecific antibodies targeting FcγRIII induce potent antitumor activity without recruiting regulatory T cells.

Caroline Rozan , Amélie Cornillon , Corinne Petiard , M. Chartier , G. Behar et al.
Molecular Cancer Therapeutics, 2013, 12 (8), pp.1481-1491. ⟨10.1158/1535-7163.MCT-12-1012⟩
Article dans une revue hal-02454959 v1
Image document

In Pancreatic Carcinoma, Dual EGFR/HER2 Targeting with Cetuximab/Trastuzumab Is More Effective than Treatment with Trastuzumab/Erlotinib or Lapatinib Alone: Implication of Receptors' Down-regulation and Dimers' Disruption.

Christel Larbouret , Nadège Gaborit , Thierry Chardès , Mickaël Coelho , Emmanuelle Campigna et al.
Neoplasia, 2012, 14 (2), pp.121-30. ⟨10.1593/neo.111602⟩
Article dans une revue inserm-00682017 v1
Image document

Time-resolved fluorescence resonance energy transfer (TR-FRET) to analyze the disruption of EGFR/HER2 dimers: a new method to evaluate the efficiency of targeted therapy using monoclonal antibodies.

Nadège Gaborit , Christel Larbouret , Julie Vallaghe , Frédéric Peyrusson , Caroline Bascoul-Mollevi et al.
Journal of Biological Chemistry, 2011, 286 (13), pp.11337-45. ⟨10.1074/jbc.M111.223503⟩
Article dans une revue inserm-00576598 v1
Image document

CD4 ligation excludes the Carma1-Bcl10-MALT1 complex from GM1-positive membrane rafts in CD3/CD28 activated T cells.

Maxime Rigo , Myriam Chentouf , André Pèlegrin , Thierry Chardès
Cellular Immunology, 2011, 270 (1), pp.40-6. ⟨10.1016/j.cellimm.2011.03.025⟩
Article dans une revue inserm-00588709 v1

Clinical radioimmunotherapy-the role of radiobiology

J.-P. Pouget , I. Navarro-Teulon , M. Bardiès , N. Chouin , G. Cartron et al.
Nature Reviews Clinical Oncology, 2011, 8 (12), pp.720--734. ⟨10.1038/nrclinonc.2011.160⟩
Article dans une revue hal-02962928 v1
Image document

Vaccination with human anti-trastuzumab anti-idiotype scFv reverses HER2 immunological tolerance and induces tumor immunity in MMTV.f.huHER2(Fo5) mice.

Maha Ladjemi , Thierry Chardes , Stephanie Corgnac , Veronique Garambois , Sebastien Morisseau et al.
Breast Cancer Research, 2011, 13 (1), pp.R17. ⟨10.1186/bcr2826⟩
Article dans une revue inserm-00649414 v1
Image document

Anti-HER2 vaccines: new prospects for breast cancer therapy.

Maha Zohra Ladjemi , William Jacot , Thierry Chardès , André Pèlegrin , Isabelle Navarro-Teulon
Cancer Immunology, Immunotherapy, 2010, 59 (9), pp.1295-312. ⟨10.1007/s00262-010-0869-2⟩
Article dans une revue inserm-00491487 v1
Image document

Cyclization of peptides through a urea bond: application to the Arg-Gly-Asp tripeptide.

Julien Schmidt , Véronique Garambois , Luc Rocheblave , Jean Martinez , André Pèlegrin et al.
ChemBioChem, 2010, 11 (8), pp.1083-92. ⟨10.1002/cbic.201000062⟩
Article dans une revue istex inserm-00482710 v1
Image document

The lipid-modulating effects of a CD4-specific recombinant antibody correlate with ZAP-70 segregation outside membrane rafts.

Myriam Chentouf , Maxime Rigo , Soufiane Ghannam , Isabelle Navarro-Teulon , Sébastien Mongrand et al.
Immunology Letters, 2010, 133 (2), pp.62-9. ⟨10.1016/j.imlet.2010.07.003⟩
Article dans une revue inserm-00508402 v1

Symplekin promotes tumorigenicity by up-regulating claudin-2 expression

Michael Buchert , Marina Papin , Caroline Bonnans , Charbel Darido , Warren Raye et al.
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (6), pp.2628-2633. ⟨10.1073/pnas.0903747107⟩
Article dans une revue hal-03108425 v1
Image document

Combined cetuximab and trastuzumab are superior to gemcitabine in the treatment of human pancreatic carcinoma xenografts.

Christelle Larbouret , Bruno Robert , Caroline Bascoul-Mollevi , Frédérique Penault-Llorca , Alexandre Ho-Pun-Cheung et al.
Annals of Oncology, 2010, 21 (1), pp.98-103. ⟨10.1093/annonc/mdp496⟩
Article dans une revue inserm-00431431 v1
Image document

Brief intraperitoneal radioimmunotherapy of small peritoneal carcinomatosis using high activities of noninternalizing 125I-labeled monoclonal antibodies.

Vincent Boudousq , Stéphanie Ricaud , Véronique Garambois , Caroline Bascoul-Mollevi , Samir Boutaleb et al.
Journal of Nuclear Medicine, 2010, 51 (11), pp.1748-55. ⟨10.2967/jnumed.110.080226⟩
Article dans une revue inserm-00531603 v1
Image document

[Anti-HER2 vaccines: The HER2 immunotargeting future?]

Maha-Zohra Ladjemi , William Jacot , André Pèlegrin , Isabelle Navarro-Teulon
Pathologie Biologie, 2009, epub ahead of print. ⟨10.1016/j.patbio.2009.04.002⟩
Article dans une revue inserm-00396298 v1
Image document

Impact of Mouse Model on Pre-Clinical Dosimetry in Targeted Radionuclide Therapy

Samir Boutaleb , Jean-Pierre Pouget , Cecilia Hindorf , André Pèlegrin , Jacques Barbet et al.
Proceedings of the IEEE, 2009, 97 (12), pp.2076-2085. ⟨10.1109/JPROC.2009.2026921⟩
Article dans une revue inserm-00452525 v1

A llama single domain anti-idiotypic antibody mimicking HER2 as a vaccine: Immunogenicity and efficacy

Nidia Alvarez-Rueda , Maha Zohra Ladjemi , Ghislaine Béhar , Stéphanie Corgnac , Martine Pugnière et al.
Vaccine, 2009, 27 (35), pp.4826-4833
Article dans une revue hal-00414283 v1

Llama single-domain antibodies directed against nonconventional epitopes of tumor-associated carcinoembryonic antigen absent from nonspecific cross-reacting antigen.

Ghislaine Behar , Patrick Chames , Isabelle Teulon , Amélie Cornillon , Faisal Alshoukr et al.
FEBS Journal, 2009, 276 (14), pp.3881-93. ⟨10.1111/j.1742-4658.2009.07101.x⟩
Article dans une revue hal-00420547 v1
Image document

[Bispecific antibodies: what future?]

André Pèlegrin , Bruno Robert
Médecine/Sciences, 2009, 25 (12), pp.1155-8. ⟨10.1051/medsci/200925121155⟩
Article dans une revue inserm-00446432 v1
Image document

Noninternalizing monoclonal antibodies are suitable candidates for 125I radioimmunotherapy of small-volume peritoneal carcinomatosis.

Lore Santoro , Samir Boutaleb , Véronique Garambois , Caroline Bascoul-Mollevi , Vincent Boudousq et al.
Journal of Nuclear Medicine, 2009, 50 (12), pp.2033-41. ⟨10.2967/jnumed.109.066993⟩
Article dans une revue inserm-00442929 v1
Image document

Adjuvant Radioimmunotherapy Trial with Iodine-131-Labeled Anti-Carcinoembryonic Antigen Monoclonal Antibody F6 F(ab')2 after Resection of Liver Metastases from Colorectal Cancer.

Marc Ychou , David Azria , Cathy Menkarios , Patrick Faurous , François Quenet et al.
Clinical Cancer Research, 2008, 14 (11), pp.3487-93. ⟨10.1158/1078-0432.CCR-07-4698⟩
Article dans une revue inserm-00292535 v1
Image document

Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy.

David Azria , Mahmut Ozsahin , Andrew Kramar , Sheila Peters , David P Atencio et al.
Clinical Cancer Research, 2008, 14 (19), pp.6284-8. ⟨10.1158/1078-0432.CCR-08-0700⟩
Article dans une revue inserm-00337542 v1
Image document

Redirecting NK cells mediated tumor cell lysis by a new recombinant bifunctional protein.

Claire Germain , Emmanuelle Campigna , Imed Salhi , Sébastien Morisseau , Isabelle Navarro-Teulon et al.
Protein Engineering, Design and Selection, 2008, 21 (11), pp.665-72. ⟨10.1093/protein/gzn047⟩
Article dans une revue inserm-00325786 v1
Image document

R-Cadherin expression inhibits myogenesis and induces myoblast transformation via Rac1 GTPase.

Jérôme Kucharczak , Sophie Charrasse , Franck Comunale , Jacques Zappulla , Bruno Robert et al.
Cancer Research, 2008, 68 (16), pp.6559-68. ⟨10.1158/0008-5472.CAN-08-0196⟩
Article dans une revue hal-00346780 v1
Image document

Cell-penetrating and cell-targeting peptides in drug delivery.

Eric Vivès , Julien Schmidt , André Pèlegrin
Biochimica et Biophysica Acta - Molecular Cell Research, 2008, 1786 (2), pp.126-38. ⟨10.1016/j.bbcan.2008.03.001⟩
Article dans une revue inserm-00281555 v1
Image document

Cell Membrane is a More Sensitive Target than Cytoplasm to Dense Ionization Produced by Auger Electrons.

Jean-Pierre Pouget , Lore Santoro , Laure Raymond , Nicolas Chouin , Manuel Bardiès et al.
Radiation Research, 2008, 170 (2), pp.192-200. ⟨10.1667/RR1359.1⟩
Article dans une revue inserm-00311037 v1
Image document

Radiocurability by targeting tumor necrosis factor-alpha using a bispecific antibody in carcinoembryonic antigen transgenic mice.

Christel Larbouret , Bruno Robert , Christine Linard , Isabelle Teulon , Sophie Gourgou et al.
International Journal of Radiation Oncology, Biology, Physics, 2007, 69 (4), pp.1231-7. ⟨10.1016/j.ijrobp.2007.07.2372⟩
Article dans une revue inserm-00225077 v1
Image document

[Combination of anti-EGFR and anti-HER2 antibodies: hope in pancreatic cancer treatment]

Christel Larbouret , Bruno Robert , Isabelle Teulon , Eric Assénat , David Azria et al.
Bulletin du Cancer, 2007, 94 (10), pp.860-2
Article dans une revue inserm-00192243 v1
Image document

[Anti-EGFR and anti-HER2 monoclonal antibodies against pancreatic carcinomas]

Christel Larbouret , Bruno Robert , Isabelle Teulon , David Azria , André Pèlegrin
Médecine/Sciences, 2007, 23 (10), pp.800-3
Article dans une revue inserm-00192336 v1

Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors.

Julie Pannequin , Nathalie Delaunay , Michael Buchert , Fanny Surrel , Jean-François Bourgaux et al.
Gastroenterology, 2007, 133 (5), pp.1554-68. ⟨10.1053/j.gastro.2007.08.023⟩
Article dans une revue hal-00315490 v1
Image document

In vivo Therapeutic Synergism of Anti-Epidermal Growth Factor Receptor and Anti-HER2 Monoclonal Antibodies against Pancreatic Carcinomas.

Christel Larbouret , Bruno Robert , Isabelle Navarro-Teulon , Simon Thèzenas , Maha-Zohra Ladjemi et al.
Clinical Cancer Research, 2007, 13 (11), pp.3356-62. ⟨10.1158/1078-0432.CCR-06-2302⟩
Article dans une revue inserm-00153693 v1

Synthesis of new cyclic RGD peptides for specific tumor cell targeting.

Florine Cavelier , Julien Schmidt , Luc Rocheblave , Jean Martinez , André Pèlegrin et al.
Peptides, 2006, pp.600
Article dans une revue hal-00117023 v1
Image document

Letrozole sensitizes breast cancer cells to ionizing radiation.

David Azria , Christel Larbouret , Severine Cunat , Mahmut Ozsahin , Sophie Gourgou et al.
Breast Cancer Research, 2005, 7, pp.R156-63. ⟨10.1186/bcr969⟩
Article dans une revue inserm-00094862 v1
Image document

Prognostic impact of epidermal growth factor receptor (EGFR) expression on loco-regional recurrence after preoperative radiotherapy in rectal cancer.

David Azria , Frédéric Bibeau , Nicolas Barbier , Abderrahim Zouhair , Claire Lemanski et al.
BMC Cancer, 2005, 5, pp.62. ⟨10.1186/1471-2407-5-62⟩
Article dans une revue inserm-00090458 v1
Image document

Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers.

Véronique Garambois , Fabienne Glaussel , Elodie Foulquier , Marc Ychou , Martine Pugnière et al.
BMC Cancer, 2004, 4, pp.75. ⟨10.1186/1471-2407-4-75⟩
Article dans une revue inserm-00103325 v1

INTERACTION OF A WATER SOLUBLE FULLERENE DERIVATIVE WITH REACTIVE OXYGEN SPECIES AND MODEL ENZYMATIC SYSTEMS

Sarah Foley , Anthony Curtis , Andreas Hirsch , Michael Brettreich , André Pèlegrin et al.
Fullerenes, Nanotubes and Carbon Nanostructures, 2002, 10 (1), pp.49 - 67. ⟨10.1081/FST-120002929⟩
Article dans une revue hal-01726320 v1

ARGD tetracyclopeptide as a new tool for specific tumor cell targeting

Julien Schmidt , B. Robert , Véronique Garambois , Luc Rocheblave , Jean Martinez et al.
30 th European Peptide Symposium, Aug 2008, Helsinki, Finland. sous presse
Communication dans un congrès hal-00353511 v1

A RGD tetracyclopeptides as a new tool for specific tumor cell targeting

Julien Schmidt , B. Robert , Véronique Garambois , L. Rocheblave , J. Martinez et al.
30th European Symposium, 2008, Helsinski, Finland. pp.380
Communication dans un congrès hal-00690437 v1

New RGD tetracyclopeptide for tumor cell targeting

Julien Schmidt , Jean Martinez , André Pèlegrin , Florine Cavelier , Eric Vivès et al.
20 th American Peptide Symposium, Jun 2007, Montreal, Canada. pp.133
Communication dans un congrès hal-00353444 v1

Synthèse de nouveaux peptides cycliques RGD pour le ciblage des tumeurs

Julien Schmidt , Luc Rocheblave , Jean Martinez , André Pèlegrin , Florine Cavelier et al.
15ème Réunion Peptides, May 2007, Dinard, France
Communication dans un congrès hal-00353050 v1