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Design and selection of optimal ErbB-targeting bispecific antibodies in pancreatic cancer
Emilia Rabia
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hal-04102843
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Carcinoembryonic Antigen–Related Cell Adhesion Molecule Type 5 Receptor–Targeted Fluorescent Intraoperative Molecular Imaging Tracer for Lung Cancer
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hal-04588970
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Improving Biologics’ Effectiveness in Clinical Oncology: From the Combination of Two Monoclonal Antibodies to Oligoclonal Antibody Mixtures
Christel Larbouret
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Article dans une revue
hal-03360265
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Anti-tumoral activity of the Pan-HER (Sym013) antibody mixture in gemcitabine-resistant pancreatic cancer models
Emilia Rabia
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Article dans une revue
hal-03360283
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Anti-Müllerian hormone concentration regulates activin receptor-like kinase-2/3 expression levels with opposing effects on ovarian cancer cell survival
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Anti-Müllerian hormone (AMH) autocrine signaling promotes survival and proliferation of ovarian cancer cells
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Article dans une revue
hal-03131997
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Multimodal CEA-Targeted Image-Guided Colorectal Cancer Surgery using 111In-Labeled SGM-101
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Biasing HER4 tyrosine kinase signaling with antibodies: Induction of cell death by antibody‐dependent HER4 intracellular domain trafficking
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hal-03036389
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Quantification of HER1, HER2 and HER3 by time-resolved Förster resonance energy transfer in FFPE triple-negative breast cancer samples
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hal-03037393
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Higher Anti-Tumor Efficacy of the Dual HER3-EGFR Antibody MEHD7945a Combined with Ionizing Irradiation in Cervical Cancer Cells
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hal-03038992
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Toxicity and pharmacokinetic profile of SGM-101, a fluorescent anti-CEA chimeric antibody for fluorescence imaging of tumors in patients
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hal-02931825
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A recycling anti-transferrin receptor-1 monoclonal antibody as an efficient therapy for erythroleukemia through target up-regulation and antibody-dependent cytotoxic effector functions
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Article dans une revue
hal-02325764
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ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells
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inserm-02280785
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An auristatin‐based antibody‐drug conjugate targeting HER3 enhances the radiation response in pancreatic cancer
Laura Bourillon
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Article dans une revue
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Quantitative proteomic analysis reveals AK2 as potential biomarker for late normal tissue radiotoxicity
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Targets for MAbs: innovative approaches for their discovery & validation, LabEx MAbImprove 6 th antibody industrial symposium, June 25-26, 2018, Montpellier, France
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Image-Guided Surgery in Patients with Pancreatic Cancer: First Results of a Clinical Trial Using SGM-101, a Novel Carcinoembryonic Antigen-Targeting, Near-Infrared Fluorescent Agent
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Safety and effectiveness of SGM-101, a fluorescent antibody targeting carcinoembryonic antigen, for intraoperative detection of colorectal cancer: a dose-escalation pilot study
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Article dans une revue
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Targeting the NRG1/HER3 pathway in tumor cells and cancer-associated fibroblasts with an anti-neuregulin 1 antibody inhibits tumor growth in pre-clinical models of pancreatic cancer
Charline Ogier
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Article dans une revue
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Antibody-drug conjugates: Design and development for therapy and imaging in and beyond cancer, LabEx MAbImprove industrial workshop, July 27–28, 2017, Tours, France
Camille Martin
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Article dans une revue
hal-02290096
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The humanized anti-human AMHRII mAb 3C23K exerts an anti-tumor activity against human ovarian cancer through tumor-associated macrophages
Houcine Bougherara
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Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis
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SGM-101: An innovative near-infrared dye-antibody conjugate that targets CEA for fluorescence-guided surgery
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Neuregulin 1 Allosterically Enhances the Antitumor Effects of the Noncompeting Anti-HER3 Antibody 9F7-F11 by Increasing Its Binding to HER3
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Article dans une revue
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The anti-tumor efficacy of 3C23K, a glyco-engineered humanized anti-MISRII antibody, in an ovarian cancer model is mainly mediated by engagement of immune effector cells
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hal-02379710
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Pregnane X-receptor promotes stem cell-mediated colon cancer relapse
Chris Planque
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Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells
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The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation
Christophe Le Clorennec
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T lymphocytes to predict radiation-induced late effects in normal tissues
Muriel Brengues
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Article dans une revue
hal-02376569
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Concurrent or sequential letrozole with adjuvant breast radiotherapy: final results of the CO-HO-RT phase II randomized trial
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hal-02338912
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Dual targeting of HER1/EGFR and HER2 with cetuximab and trastuzumab in patients with metastatic pancreatic cancer after gemcitabine failure: results of the "THERAPY"phase 1-2 trial
Eric Assenat
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hal-02005981
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Examination of HER3 targeting in cancer using monoclonal antibodies
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Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (3), pp.839-844. ⟨10.1073/pnas.1423645112⟩
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hal-02276327
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The HER3/ERBB3 receptor: the dark side of the ERBB planet
Christel Larbouret
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Marie-Alix Poul
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hal-02285139
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Neutralization of KIT Oncogenic Signaling in Leukemia with Antibodies Targeting KIT Membrane Proximal Domain 5
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hal-02329816
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Radiation-induced CD8 T-lymphocyte Apoptosis as a Predictor of Breast Fibrosis After Radiotherapy: Results of the Prospective Multicenter French Trial
David Azria
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Article dans une revue
hal-02338826
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Late side-effects after curative intent radiotherapy: Identification of hypersensitive patients for personalized strategy
Céline Bourgier
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hal-02148578
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Preclinical validation of AXL receptor as a target for antibody-based pancreatic cancer immunotherapy.
Wilhem Leconet
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Article dans une revue
inserm-00916587
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HER3 as biomarker and therapeutic target in pancreatic cancer: new insights in pertuzumab therapy in preclinical models
Gaëlle Thomas
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hal-02387994
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MAbImprove: a French "Laboratoire d'excellence" (LabEx) dedicated to therapeutic antibodies
Andre Pelegrin
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Article dans une revue
hal-02168048
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The human Mullerian inhibiting substance type II receptor as immunotherapy target for ovarian cancer. Validation using the mAb 12G4
Nathalie Kersual
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Jean-Pierre Pouget
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Article dans une revue
hal-02168055
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DNA damage-centered signaling pathways are effectively activated during low dose-rate Auger radioimmunotherapy.
Bérengère Piron
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Article dans une revue
inserm-00981411
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Peptides in Receptor-Mediated Radiotherapy: From Design to the Clinical Application in Cancers
Catherine Lozza
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Article dans une revue
hal-03824440
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Comparison between Internalizing Anti-HER2 mAbs and Non-Internalizing Anti-CEA mAbs in Alpha-Radioimmunotherapy of Small Volume Peritoneal Carcinomatosis Using (2) (1) (2)Pb.
Vincent Boudousq
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Article dans une revue
inserm-00853390
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Anti-HER3 domain 1 and 3 antibodies reduce tumor growth by hindering HER2/HER3 dimerization and AKT-induced MDM2, XIAP, and FoxO1 phosphorylation.
Yassamine Lazrek
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Article dans une revue
inserm-00815985
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Radiosensibilité individuelle : les tests vont changer nos pratiques
J. Lacombe
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Article dans une revue
istex
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Apoptosis and p53 are not involved in the anti-tumor efficacy of (125)I-labeled monoclonal antibodies targeting the cell membrane.
Salomé Paillas
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Article dans une revue
inserm-00815724
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Single-domain antibody-based and linker-free bispecific antibodies targeting FcγRIII induce potent antitumor activity without recruiting regulatory T cells.
Caroline Rozan
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Article dans une revue
hal-02454959
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In Pancreatic Carcinoma, Dual EGFR/HER2 Targeting with Cetuximab/Trastuzumab Is More Effective than Treatment with Trastuzumab/Erlotinib or Lapatinib Alone: Implication of Receptors' Down-regulation and Dimers' Disruption.
Christel Larbouret
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Thierry Chardès
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Mickaël Coelho
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Article dans une revue
inserm-00682017
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Time-resolved fluorescence resonance energy transfer (TR-FRET) to analyze the disruption of EGFR/HER2 dimers: a new method to evaluate the efficiency of targeted therapy using monoclonal antibodies.
Nadège Gaborit
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Christel Larbouret
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Julie Vallaghe
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Article dans une revue
inserm-00576598
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CD4 ligation excludes the Carma1-Bcl10-MALT1 complex from GM1-positive membrane rafts in CD3/CD28 activated T cells.
Maxime Rigo
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Myriam Chentouf
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André Pèlegrin
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Thierry Chardès
Article dans une revue
inserm-00588709
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Clinical radioimmunotherapy-the role of radiobiology
J.-P. Pouget
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Article dans une revue
hal-02962928
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Vaccination with human anti-trastuzumab anti-idiotype scFv reverses HER2 immunological tolerance and induces tumor immunity in MMTV.f.huHER2(Fo5) mice.
Maha Ladjemi
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Article dans une revue
inserm-00649414
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Anti-HER2 vaccines: new prospects for breast cancer therapy.
Maha Zohra Ladjemi
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Article dans une revue
inserm-00491487
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Cyclization of peptides through a urea bond: application to the Arg-Gly-Asp tripeptide.
Julien Schmidt
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Article dans une revue
istex
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The lipid-modulating effects of a CD4-specific recombinant antibody correlate with ZAP-70 segregation outside membrane rafts.
Myriam Chentouf
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Article dans une revue
inserm-00508402
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Symplekin promotes tumorigenicity by up-regulating claudin-2 expression
Michael Buchert
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Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (6), pp.2628-2633. ⟨10.1073/pnas.0903747107⟩
Article dans une revue
hal-03108425
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Combined cetuximab and trastuzumab are superior to gemcitabine in the treatment of human pancreatic carcinoma xenografts.
Christelle Larbouret
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Article dans une revue
inserm-00431431
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Brief intraperitoneal radioimmunotherapy of small peritoneal carcinomatosis using high activities of noninternalizing 125I-labeled monoclonal antibodies.
Vincent Boudousq
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Article dans une revue
inserm-00531603
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[Anti-HER2 vaccines: The HER2 immunotargeting future?]
Maha-Zohra Ladjemi
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Article dans une revue
inserm-00396298
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Impact of Mouse Model on Pre-Clinical Dosimetry in Targeted Radionuclide Therapy
Samir Boutaleb
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Article dans une revue
inserm-00452525
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A llama single domain anti-idiotypic antibody mimicking HER2 as a vaccine: Immunogenicity and efficacy
Nidia Alvarez-Rueda
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Vaccine, 2009, 27 (35), pp.4826-4833
Article dans une revue
hal-00414283
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Llama single-domain antibodies directed against nonconventional epitopes of tumor-associated carcinoembryonic antigen absent from nonspecific cross-reacting antigen.
Ghislaine Behar
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Article dans une revue
hal-00420547
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[Bispecific antibodies: what future?]
André Pèlegrin
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Article dans une revue
inserm-00446432
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Noninternalizing monoclonal antibodies are suitable candidates for 125I radioimmunotherapy of small-volume peritoneal carcinomatosis.
Lore Santoro
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Véronique Garambois
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Article dans une revue
inserm-00442929
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Adjuvant Radioimmunotherapy Trial with Iodine-131-Labeled Anti-Carcinoembryonic Antigen Monoclonal Antibody F6 F(ab')2 after Resection of Liver Metastases from Colorectal Cancer.
Marc Ychou
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Cathy Menkarios
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Article dans une revue
inserm-00292535
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Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy.
David Azria
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Andrew Kramar
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Article dans une revue
inserm-00337542
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Redirecting NK cells mediated tumor cell lysis by a new recombinant bifunctional protein.
Claire Germain
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Sébastien Morisseau
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Article dans une revue
inserm-00325786
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R-Cadherin expression inhibits myogenesis and induces myoblast transformation via Rac1 GTPase.
Jérôme Kucharczak
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Franck Comunale
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Article dans une revue
hal-00346780
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Cell-penetrating and cell-targeting peptides in drug delivery.
Eric Vivès
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Article dans une revue
inserm-00281555
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Cell Membrane is a More Sensitive Target than Cytoplasm to Dense Ionization Produced by Auger Electrons.
Jean-Pierre Pouget
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Article dans une revue
inserm-00311037
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Radiocurability by targeting tumor necrosis factor-alpha using a bispecific antibody in carcinoembryonic antigen transgenic mice.
Christel Larbouret
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Bruno Robert
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Christine Linard
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Article dans une revue
inserm-00225077
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[Combination of anti-EGFR and anti-HER2 antibodies: hope in pancreatic cancer treatment]
Christel Larbouret
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Isabelle Teulon
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Eric Assénat
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Bulletin du Cancer, 2007, 94 (10), pp.860-2
Article dans une revue
inserm-00192243
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[Anti-EGFR and anti-HER2 monoclonal antibodies against pancreatic carcinomas]
Christel Larbouret
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Bruno Robert
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Isabelle Teulon
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David Azria
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André Pèlegrin
Médecine/Sciences, 2007, 23 (10), pp.800-3
Article dans une revue
inserm-00192336
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Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors.
Julie Pannequin
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Article dans une revue
hal-00315490
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In vivo Therapeutic Synergism of Anti-Epidermal Growth Factor Receptor and Anti-HER2 Monoclonal Antibodies against Pancreatic Carcinomas.
Christel Larbouret
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Bruno Robert
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Simon Thèzenas
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Article dans une revue
inserm-00153693
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Synthesis of new cyclic RGD peptides for specific tumor cell targeting.
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Letrozole sensitizes breast cancer cells to ionizing radiation.
David Azria
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Prognostic impact of epidermal growth factor receptor (EGFR) expression on loco-regional recurrence after preoperative radiotherapy in rectal cancer.
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Fully human IgG and IgM antibodies directed against the carcinoembryonic antigen (CEA) Gold 4 epitope and designed for radioimmunotherapy (RIT) of colorectal cancers.
Véronique Garambois
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INTERACTION OF A WATER SOLUBLE FULLERENE DERIVATIVE WITH REACTIVE OXYGEN SPECIES AND MODEL ENZYMATIC SYSTEMS
Sarah Foley
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