Angélique Stéphanou

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Publications

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Beyond the Warburg Effect: Modeling the Dynamic and Context-Dependent Nature of Tumor Metabolism

Pierre Jacquet , Angélique Stéphanou

Cancers, 2025, 17 (21), pp.3563. ⟨10.3390/cancers17213563⟩

Article dans une revue hal-05348279v1

Spatial organization of mediated-macrophage chemoprotective niches in solid tumors: A mathematical analysis

William Dangelser , Angélique Stéphanou , Arnaud Millet

Mathematical Modelling of Natural Phenomena, 2025, 20, pp.15. ⟨10.1051/mmnp/2025012⟩

Article dans une revue hal-04798016v1
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Modelling the impact of HIF on metabolism and the extracellular matrix: consequences for tumour growth and invasion

Kévin Spinicci , Gibin Powathil , Angélique Stéphanou

Bulletin of Mathematical Biology, 2025, 87 (27), ⟨10.1007/s11538-024-01391-0⟩

Article dans une revue hal-04754067v1
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The Role of Mathematical Models in Epidemic Prediction and the Challenges of COVID-19 Comment on 'Data-driven mathematical modeling approaches for COVID-19: A survey' by

E Fanchon , Angélique Stéphanou

Physics of Life Reviews, 2025, 52, pp.55-56. ⟨10.1016/j.plrev.2024.12.002⟩

Article dans une revue hal-04766375v1
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A biomechanical model for cell sensing and migration

Arnaud Chauvière , Ian Manifacier , Claude Verdier , Grégory Chagnon , Ibrahim Cheddadi et al.

Computer Methods in Biomechanics and Biomedical Engineering, 2024, pp.1-19. ⟨10.1080/10255842.2024.2427112⟩

Article dans une revue hal-04727238v1
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On the Importance of Acidity in Cancer Cells and Therapy

Alaa Tafech , Angélique Stéphanou

Biology, 2024, 13 (4), pp.225. ⟨10.3390/biology13040225⟩

Article dans une revue (article de synthèse) hal-04527526v1
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Is Cancer Metabolism an Atavism?

Éric Fanchon , Angélique Stéphanou

Cancers, 2024, The Warburg Effect in Cancers, 16 (13), pp.2415. ⟨10.3390/cancers16132415⟩

Article dans une revue hal-04636868v1
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Generalization of the Ratiometric Method to Extend pH Range Measurements of the BCECF Probe

Alaa Tafech , Céline Beaujean , Yves Usson , Angélique Stéphanou

Biomolecules, 2023, 13 (3), pp.442. ⟨10.3390/biom13030442⟩

Article dans une revue hal-04287591v1
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A reduced model of cell metabolism to revisit the glycolysis-OXPHOS relationship in the deregulated tumor microenvironment

Pierre Jacquet , Angélique Stéphanou

Journal of Theoretical Biology, 2023, 562, pp.111434. ⟨10.1016/j.jtbi.2023.111434⟩

Article dans une revue hal-03973607v1
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Characterization of the Intracellular Acidity Regulation of Brain Tumor Cells and Consequences for Therapeutic Optimization of Temozolomide

Alaa Tafech , Pierre Jacquet , Céline Beaujean , Arnold Fertin , Yves Usson et al.

Biology, 2023, 12 (9), pp.1221. ⟨10.3390/biology12091221⟩

Article dans une revue hal-04208184v1
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Searching for the Metabolic Signature of Cancer: A Review from Warburg’s Time to Now

Pierre Jacquet , Angélique Stéphanou

Biomolecules, 2022, 12 (10), pp.1412. ⟨10.3390/biom12101412⟩

Article dans une revue hal-03813369v1
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Modelling the role of HIF in the regulation of metabolic key genes LDH and PDH: Emergence of Warburg Phenotype

Kévin Spinicci , Pierre Jacquet , Gibin Powathil , Angélique Stéphanou

Computational and Systems Oncology, 2022, 2 (3), ⟨10.1002/cso2.1040⟩

Article dans une revue hal-03759747v1
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Can major breakthroughs in cancer be achieved through theoretical models? Comment on “Improving cancer treatments via dynamical biophysical models” by M. Kuznetsov, J. Clairambault and V. Volpert

Angélique Stéphanou

Physics of Life Reviews, 2022, 40, pp.63-64. ⟨10.1016/j.plrev.2021.11.006⟩

Article dans une revue hal-03470089v1
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Metabolic Reprogramming, Questioning, and Implications for Cancer

Pierre Jacquet , Angélique Stéphanou

Biology, 2021, 10 (2), pp.129. ⟨10.3390/biology10020129⟩

Article dans une revue hal-03151101v1
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Hybrid Modelling in Oncology: Sucesses, Challenges and Hopes

Angélique Stéphanou , Pascal Ballet , Gibin Powathil

Mathematical Modelling of Natural Phenomena, 2020, 15, ⟨10.1051/mmnp/2019026⟩

Article dans une revue hal-01980757v1
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A minimal biomechanical model for random cell migration

Ian Manifacier , Arnaud Chauvière , Claude Verdier , G. Chagnon , Ibrahim Cheddadi et al.

Computer Methods in Biomechanics and Biomedical Engineering, 2020, 45th Congress of the Société de Biomécanique, 23 (sup1), pp.S183-S185. ⟨10.1080/10255842.2020.1813420⟩

Article dans une revue hal-03015234v1
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On the importance of substrate deformations for cell migration

Anais Gagnieu , Grégory Chagnon , Yves Chemisky , Angélique Stephanou , Arnaud Chauvière

Computer Methods in Biomechanics and Biomedical Engineering, 2020, 22 suppl 1, pp.S334-S335. ⟨10.1080/10255842.2020.1714933⟩

Article dans une revue hal-02425956v1
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A minimal biomechanical model for random cell migration

Ian Manifacier , Arnaud Chauvière , Claude Verdier , Gregory Chagnon , Ibrahim Cheddadi et al.

Computer Methods in Biomechanics & Biomedical Engineering, 2020, ⟨10.1080/10255842.2020.1813420⟩

Article dans une revue hal-02985515v1
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pH as a potential therapeutic target to improve temozolomide antitumor efficacy : A mechanistic modeling study

Angélique Stéphanou , Annabelle Ballesta

Pharmacology Research & Perspectives, 2019, 7 (1), pp.e00454. ⟨10.1002/prp2.454⟩

Article dans une revue hal-03015254v1
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Systems Biology, Systems Medicine, Systems Pharmacology: The What and The Why

Angélique Stéphanou , Eric Fanchon , Pasquale Innominato , Annabelle Ballesta

Acta Biotheoretica, 2018, 66 (4), pp.345-365. ⟨10.1007/s10441-018-9330-2⟩

Article dans une revue hal-01975961v1

How tumour-induced vascular changes alter angiogenesis: Insights from a computational model

Angélique Stéphanou , Anne-Cécile Lesart , J. Deverchere , A. Juhem , A. Popov et al.

Journal of Theoretical Biology, 2017, 419, pp.211-226. ⟨10.1016/j.jtbi.2017.02.018⟩

Article dans une revue hal-01975971v1
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Towards the Design of a Patient-Specific Virtual Tumour

Flavien Caraguel , Anne-Cécile Lesart , François Estève , Boudewijn Pj van Der Sanden , Angélique Stéphanou

Computational and Mathematical Methods in Medicine, 2016, 2016, pp.7851789. ⟨10.1155/2016/7851789⟩

Article dans une revue hal-01975976v1

Effects of the hypoxia-mimetic agents DFO and CoCl2 on HeLa-FUCCI cells

Baptiste Bedessem , Marie-Paule Montmasson , Malika Hamel , Françoise Giroud , Angélique Stéphanou

Journal of Cell Biology and Cell Metab, 2015, 2, pp.4-12. ⟨10.24966/cbcm-1943/100004⟩

Article dans une revue hal-01483598v1

Hybrid Modelling in Cell Biology

Angélique Stéphanou , Vitaly Volpert

Mathematical Modelling of Natural Phenomena, 2015, 10 (1), pp.1-3. ⟨10.1051/mmnp/201510100⟩

Article dans une revue hal-01975989v1
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A mathematical model of HiF-1α-mediated response to hypoxia on the G1/S transition

Baptiste Bedessem , Angélique Stéphanou

Mathematical Biosciences, 2014, 248, pp.31-9. ⟨10.1016/j.mbs.2013.11.007⟩

Article dans une revue hal-00977635v1

Proceedings of the XXXIInd Seminar of the French-Speaking Society for Theoretical Biology; Saint-Flour (Cantal), France, 10-13 June, 2012.

Nicolas Glade , Angélique Stéphanou

Acta Biotheoretica, 2013, 61 (3), pp.289-90. ⟨10.1007/s10441-013-9201-9⟩

Article dans une revue hal-00977696v1

Mathematical modelling and numerical simulations of actin dynamics in the eukaryotic cell.

Uduak Z George , Angélique Stéphanou , Anotida Madzvamuse

Journal of Mathematical Biology, 2013, 66 (3), pp.547-93. ⟨10.1007/s00285-012-0521-1⟩

Article dans une revue istex hal-00847003v1

A Computational Framework to Assess the Efficacy of Cytotoxic Molecules and Vascular Disrupting Agents against Solid Tumours

Margarita Pons-Salort , Boudewijn van Der Sanden , Aurélie Juhem , Andrei Popov , Angélique Stéphanou

Mathematical Modelling of Natural Phenomena, 2012, 7 (1), pp.49-77. ⟨10.1051/mmnp/20127104⟩

Article dans une revue hal-00847022v1
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On the importance of the submicrovascular network in a computational model of tumour growth.

Anne-Cécile Lesart , Boudewijn van Der Sanden , Lauriane Hamard , François Estève , Angélique Stéphanou

Microvascular Research, 2012, 84 (2), pp.188-204. ⟨10.1016/j.mvr.2012.06.001⟩

Article dans une revue inserm-00738177v1

On the Influence of Discrete Adhesive Patterns for Cell Shape and Motility: A Computational Approach

Céline Franco , Tzvetelina Tzvetkova-Chevolleau , Angélique Stéphanou

Mathematical Modelling of Natural Phenomena, 2010, 5 (1), pp.56 - 83. ⟨10.1051/mmnp/20105101⟩

Article dans une revue hal-00847012v1

Modelling the Impact of Pericyte Migration and Coverage of Vessels on the Efficacy of Vascular Disrupting Agents

Steven Mcdougall , Mark A.J. Chaplain , Angélique Stéphanou , Alexander R.A. Anderson

Mathematical Modelling of Natural Phenomena, 2010, 5 (1), pp.163-202. ⟨10.1051/mmnp/20105108⟩

Article dans une revue hal-00847029v1
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The motility of normal and cancer cells in response to the combined influence of substrate rigidity and anisotropic microstructure

Tzvetelina Tzvetkova-Chevolleau , Angélique Stéphanou , David Fuard , Jacques Ohayon , Patrick Schiavone et al.

Biomaterials, 2008, 29 (10), pp.1541--1551. ⟨10.1016/j.biomaterials.2007.12.016⟩

Article dans une revue hal-00291559v1

Spatiotemporal dynamics of actin-rich adhesion microdomains: influence of substrate flexibility

O. Collin , Angélique Stéphanou

Journal of Cell Science, 2006, 119 (9), pp.1914-1925

Article dans une revue hal-01976004v1

Spatiotemporal dynamics of actin-rich adhesion microdomains: influence of substrate flexibility.

Olivier Collin , Philippe Tracqui , Angélique Stephanou , Yves Usson , Jocelyne Clément-Lacroix et al.

Journal of Cell Science, 2006, 119 (Pt 9), pp.1914-25. ⟨10.1242/jcs.02838⟩

Article dans une revue inserm-00173037v1

The rigidity in fibrin gels as a contributing factor to the dynamics of in vitro vascular cord formation

Angélique Stephanou , Ghislaine Meskaoui , Vailhé Bruno , Philippe Tracqui

Microvascular Research, 2006, 73 (3), pp.182-190. ⟨10.1016/j.mvr.2006.12.002⟩

Article dans une revue istex hal-00193847v1

A mathematical model for the dynamics of large membrane deformations of isolated fibroblasts

Angélique Stéphanou

Bulletin of Mathematical Biology, 2004, 66 (5), pp.1119-1154

Article dans une revue hal-01976003v1

Development of a Preclinical Tool for Measuring Percutaneous Transfer of Dihydrogen, with a View to Optimizing Medical Devices Adapted to Focal Therapies in Dermatology

C. Salomez-Ihl , S. Tanguy , F. Boucher , V. Pascal Mousselard , P. Bedouch et al.

Molecular Hydrogen in Health and Disease, 27, Springer Nature Switzerland, pp.401-416, 2024, Advances in Biochemistry in Health and Disease, ⟨10.1007/978-3-031-47375-3_23⟩

Chapitre d'ouvrage hal-04467191v1

A computational framework integrating cytoskeletal and adhesion dynamics for modelling cell motility

Angélique Stéphanou

Cell mechanics: from single scale-based models to multiscale modeling, Chapman & Hall/CRC Mathematical and Computational Biology, pp.482, 2010, 9781420094541

Chapitre d'ouvrage hal-00977684v1

Modélisation de la motilité cellulaire perturbée par l'interaction cellule-substrat

Anais Gagnieu , Arnaud Chauvière , Grégory Chagnon , Yves Chemisky , Angélique Stephanou

38ème Séminaire de la Société Francophone de Biologie Théorique, Jun 2018, Sainf Flour, France

Communication dans un congrès hal-01890322v1
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Hybrid modelling of mechanical cues in cell migration

Angélique Stéphanou , Simon Lefloch , Arnaud Chauvière

ITM Conference 2015, Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology, Mar 2015, Paris, France. ⟨10.1051/itmconf/20150500012⟩

Communication dans un congrès hal-01550582v1

Reduced Model For 2D Tumor Growth and Tumor Induced Angiogenesis

Mazen Alamir , Mirko Fiacchini , Angélique Stephanou

ECC 2015 - 14th European Control Conference, Jul 2015, Linz, Austria

Communication dans un congrès hal-01235354v1

The Motility of Normal and Cancer Cells in Response to the Combined Influence of Substrate Rigidity and Anisotropic Nanostructure

Tzvetelina Tzvetkova-Chevolleau , Angélique Stephanou , David Fuard , Jacques Ohayon , Patrick Schiavone et al.

ICBME2008, 13th International Conference on Biomedical Engineering, 2008, Singapore, Singapore

Communication dans un congrès hal-00374519v1

Control of cell morphodynamic and displacement orientation by precise tuning between substrate nanopatterning and rigidity

Tzvetelina Tzvetkova-Chevolleau , David Fuard , Patrick Schiavone , Sébastien Decossas , Angélique Stéphanou et al.

Nanobio Europe 2008, Jun 2008, Barcelona, Spain

Communication dans un congrès hal-00340397v1

Mathematical Modelling of Fibroblast shape Transition on Arrays of Adhesive Micropatterns with Varying Pitch

Angélique Stéphanou , Tzvetelina Tzvetkova-Chevolleau , David Fuard , Philippe Tracqui , Patrick Schiavone

ECMTB08; European Conference on Mathematical and Theoretical Biology, Jun 2008, Edinburgh, United Kingdom

Communication dans un congrès hal-00340399v1
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The spatio-temporal dynamics of cell membranes deformations and cell migration

Angélique Stéphanou

Modeling and Simulation. Université Joseph-Fourier - Grenoble I, 2002. English. ⟨NNT : ⟩

Thèse tel-00004593v1