Access content directly

Anne Houdusse

63
Documents

Publications

Image document

How myosin VI traps its off-state, is activated and dimerizes

Louise Canon , Vicente Planelles-Herrero , Young Il Lee , Franck Mayeux , Tianming Lin
Nature Communications, 2023, 14 (1), pp.6732. ⟨10.1038/s41467-023-42376-2⟩
Journal articles hal-04293608v1
Image document

Cryo-EM structure of the folded-back state of human β-cardiac myosin

Alessandro Grinzato , Daniel Auguin , Carlos Kikuti , Neha Nandwani , Dihia Moussaoui
Nature Communications, 2023, 14 (1), pp.3166. ⟨10.1038/s41467-023-38698-w⟩
Journal articles hal-04267665v1
Image document

The many roles of myosins in filopodia, microvilli and stereocilia

Anne Houdusse , Margaret A Titus
Current Biology - CB, 2021, 31 (10), pp.R586-R602. ⟨10.1016/j.cub.2021.04.005⟩
Journal articles hal-03281243v1
Image document

Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance

Catalina Lodillinsky , Laetitia Fuhrmann , Marie Irondelle , Olena Pylypenko , Xiao-Yan Li
Oncogene, 2021, 40 (23), pp.4019 - 4032. ⟨10.1038/s41388-021-01826-1⟩
Journal articles hal-03453132v1

Integration of Cardiac Actin Mutants Causing Hypertrophic (p.A295S) and Dilated Cardiomyopathy (p.R312H and p.E361G) into Cellular Structures

Constanze Erdmann , Roua Hassoun , Sebastian Schmitt , Carlos Kikuti , Anne Houdusse
Antioxidants , 2021, 10 (7), pp.1082. ⟨10.3390/antiox10071082⟩
Journal articles hal-03453111v1
Image document

The actomyosin interface contains an evolutionary conserved core and an ancillary interface involved in specificity

Julien Robert-Paganin , Xiao-Ping Xu , Mark Swift , Daniel Auguin , James Robblee
Nature Communications, 2021, 12 (1), pp.1892. ⟨10.1038/s41467-021-22093-4⟩
Journal articles hal-03453769v1
Image document

Biological nanomotors, driving forces of life

Anne Houdusse
Comptes Rendus. Biologies, 2021, 343 (4), pp.53-78. ⟨10.5802/crbiol.45>⟩
Journal articles hal-03453097v1

Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth

Lara Katharina Krüger , Matthieu Gélin , Liang Ji , Carlos Kikuti , Anne Houdusse
eLife, 2021, 10, ⟨10.7554/eLife.67489⟩
Journal articles hal-03453181v1
Image document

Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance

Catalina Lodillinsky , Laetitia Fuhrmann , Marie Irondelle , Olena Pylypenko , Xiao-Yan Li
Journal articles hal-03238972v1
Image document

Kinesin-6 Klp9 orchestrates spindle elongation by regulating microtubule sliding and growth

Lara Katharina Krüger , Matthieu Gélin , Liang Ji , Carlos Kikuti , Anne Houdusse
eLife, 2021, 10, pp.e67489. ⟨10.7554/eLife.67489⟩
Journal articles hal-03258505v1
Image document

VASP-mediated actin dynamics activate and recruit a filopodia myosin

Ashley L Arthur , Amy Crawford , Anne Houdusse , Margaret A Titus
eLife, 2021, 10, ⟨10.7554/elife.68082⟩
Journal articles hal-03395283v1
Image document

Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness

Máté Gyimesi , Ádám Horváth , Demeter Túrós , Sharad Kumar Suthar , Máté Pénzes
Cell, 2020, 183 (2), pp.335-346.e13. ⟨10.1016/j.cell.2020.08.050⟩
Journal articles hal-03453772v1
Image document

Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets

Dihia Moussaoui , James P Robblee , Daniel Auguin , Elena B Krementsova , Silvia Haase
eLife, 2020, 9, pp.e60581. ⟨10.7554/elife.60581⟩
Journal articles hal-03059341v1
Image document

Force Generation by Myosin Motors: A Structural Perspective

Julien Robert-Paganin , Olena Pylypenko , Carlos Kikuti , H. Lee Sweeney , Anne Houdusse
Chemical Reviews, 2020, 120 (1), pp.5-35. ⟨10.1021/acs.chemrev.9b00264⟩
Journal articles hal-03238440v1

Optimized filopodia formation requires myosin tail domain cooperation

Ashley Arthur , Livia Songster , Helena Sirkia , Akash Bhattacharya , Carlos Kikuti
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (44), pp.22196-22204. ⟨10.1073/pnas.1901527116⟩
Journal articles hal-02349330v1

2nd PSL Chemical Biology Symposium (2019): At the Crossroads of Chemistry and Biology

Marco Lucchino , Anne Billet , Antoine Versini , Harikrishna Bavireddi , Bhanu-Das Dasari
ChemBioChem, 2019, 20 (7), pp.968-973. ⟨10.1002/cbic.201900092⟩
Journal articles hal-02324665v1
Image document

Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism

Julien Robert-Paganin , James Robblee , Daniel Auguin , Thomas Blake , Carol Bookwalter
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-11120-0⟩
Journal articles hal-02349247v1
Image document

Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism

Julien Robert-Paganin , James P Robblee , Daniel Auguin , Thomas C A Blake , Carol S Bookwalter
Nature Communications, 2019, 10, ⟨10.1038/s41467-019-11120-0⟩
Journal articles hal-03059356v1
Image document

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

Julien Robert-Paganin , Daniel Auguin , Anne Houdusse
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-06191-4⟩
Journal articles hal-02349257v1
Image document

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

Julien Robert-Paganin , Daniel Auguin , Anne Houdusse
Nature Communications, 2018, 9, ⟨10.1038/s41467-018-06191-4⟩
Journal articles hal-03059371v1
Image document

Circularly permuted fluorogenic proteins for the design of modular biosensors

Alison G Tebo , Frederico M Pimenta , Martha Zoumpoulaki , Carlos Kikuti , Helena Sirkia
ACS Chemical Biology, 2018, 13 (9), pp.2392 - 2397. ⟨10.1021/acschembio.8b00417⟩
Journal articles hal-01909679v1

MYO5B , STX3 , and STXBP2 mutations reveal a common disease mechanism that unifies a subset of congenital diarrheal disorders: A mutation update

Herschel Dhekne , Olena Pylypenko , Arend Overeem , Rosaria Ferreira , K. Joeri van Der Velde
Human Mutation, 2018, 39 (3), pp.333-344. ⟨10.1002/humu.23386⟩
Journal articles hal-02349537v1

An intermediate along the recovery stroke of myosin VI revealed by X-ray crystallography and molecular dynamics

Florian Blanc , Tatiana Isabet , Hannah Benisty , H. Lee Sweeney , Marco Cecchini
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (24), pp.6213-6218. ⟨10.1073/pnas.1711512115⟩
Journal articles hal-02349286v1
Image document

Myosin VI and branched actin filaments mediate membrane constriction and fission of melanosomal tubule carriers

Léa Ripoll , Xavier Heiligenstein , Ilse Hurbain , Lia Domingues , Florent Figon
Journal of Cell Biology, 2018, 217 (8), pp.2709 - 2726. ⟨10.1083/jcb.201709055⟩
Journal articles hal-03059386v1
Image document

The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry

Joseph Atherton , I-Mei Yu , Alexander Cook , Joseph M Muretta , Agnel Joseph
Journal articles hal-04015847v1
Image document

Oxidation of F-actin controls the terminal steps of cytokinesis

Stéphane Frémont , Hussein Hammich , Jian Bai , Hugo Wioland , Kerstin Klinkert
Nature Communications, 2017, 8, pp.1-16. ⟨10.1038/ncomms14528⟩
Journal articles hal-01492528v1
Image document

Myosin 7 and its adaptors link cadherins to actin

I-Mei Yu , Vicente J Planelles-Herrero , Yannick Sourigues , Dihia Moussaoui , Helena Sirkia
Nature Communications, 2017, 8, pp.15864. ⟨10.1038/ncomms15864⟩
Journal articles hal-01984704v1
Image document

Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil

Vicente J Planelles-Herrero , James J Hartman , Julien Robert-Paganin , Fady I Malik , Anne Houdusse
Nature Communications, 2017, 8 (1), ⟨10.1038/s41467-017-00176-5⟩
Journal articles hal-03059358v1
Image document

Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions

Stephanie Miserey-Lenkei , Hugo Bousquet , Olena Pylypenko , Sabine Bardin , Ariane Dimitrov
Nature Communications, 2017, 8 (1), pp.1254. ⟨10.1038/s41467-017-01266-0⟩
Journal articles hal-02349571v1

Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex

Sara Bizzotto , Ana Uzquiano , Florent Dingli , Dmitry Ershov , Anne Houllier
Scientific Reports, 2017, 7 (1), pp.17308. ⟨10.1038/s41598-017-15253-4⟩
Journal articles hal-03825519v1

Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversity

Olena Pylypenko , Hussein Hammich , I-Mei Yu , Anne Houdusse
Small GTPases, 2017, 9 (1-2), pp.22-48. ⟨10.1080/21541248.2017.1336191⟩
Journal articles hal-02349559v1
Image document

The myosin X motor is optimized for movement on actin bundles

Virginie Ropars , Zhaohui Yang , Tatiana Isabet , Florian Blanc , Kaifeng Zhou
Nature Communications, 2016, 7, pp.12456. ⟨10.1038/ncomms12456⟩
Journal articles hal-01361523v1
Image document

Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes

Olena Pylypenko , Tobias Welz , Janine Tittel , Martin Kollmar , Florian Chardon
eLife, 2016, 5, pp.e17523. ⟨10.7554/eLife.17523⟩
Journal articles hal-02349587v1

Force-producing ADP state of myosin bound to actin

Sarah Wulf , Virginie Ropars , Setsuko Fujita-Becker , Marco Oster , Goetz Hofhaus
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (13), pp.E1844-E1852. ⟨10.1073/pnas.1516598113⟩
Journal articles hal-02349597v1
Image document

Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening.

Kerstin Klinkert , Murielle Rocancourt , Anne Houdusse , Arnaud Echard
Nature Communications, 2016, 7, pp.11166. ⟨10.1038/ncomms11166⟩
Journal articles pasteur-01301777v1
Image document

Myosin VI deafness mutation prevents the initiation of processive runs on actin

Olena Pylypenko , Lin Song , Ai Shima , Zhaohui Yang , Anne Houdusse
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112, pp.E1201 - E1209. ⟨10.1073/pnas.1420989112⟩
Journal articles hal-03059375v1
Image document

How Actin Initiates the Motor Activity of Myosin

Paola Llinas , Tatiana Isabet , Lin Song , Virginie Ropars , Bin Zong
Developmental Cell, 2015, 33, pp.401 - 412. ⟨10.1016/j.devcel.2015.03.025⟩
Journal articles hal-03059350v1

Myosin VI deafness mutation prevents the initiation of processive runs on actin

Olena Pylypenko , Lin Song , Ai Shima , Zhaohui Yang , Anne Houdusse
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (11), pp.E1201-E1209. ⟨10.1073/pnas.1420989112⟩
Journal articles hal-02349599v1

How actin initiates the motor activity of Myosin.

Paola Llinas , Tatiana Isabet , Lin Song , Virginie Ropars , Bin Zong
Developmental Cell, 2015, 33 (4), pp.401-12. ⟨10.1016/j.devcel.2015.03.025⟩
Journal articles hal-01447817v1

Structural basis of myosin V Rab GTPase-dependent cargo recognition

Olena Pylypenko , Wikayatou Attanda , Charles Gauquelin , Marion Lahmani , Doudouh Coulibaly
Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (51), pp.20443 - 20448. ⟨10.1073/pnas.1314329110⟩
Journal articles pasteur-03525520v1

Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI

Julie Ménétrey , Tatiana Isabet , Virginie Ropars , Monalisa Mukherjea , Olena Pylypenko
Molecular Cell, 2012, 48 (1), pp.75-86. ⟨10.1016/j.molcel.2012.07.034⟩
Journal articles hal-02349630v1
Image document

Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI

Julie Ménétrey , Tatiana Isabet , Virginie Ropars , Monalisa Mukherjea , Olena Pylypenko
Molecular Cell, 2012, 48 (1), pp.75 - 86. ⟨10.1016/j.molcel.2012.07.034⟩
Journal articles hal-03059379v1

How myosin motors power cellular functions - an exciting journey from structure to function

Paola Llinas , Olena Pylypenko , Tatiana Isabet , Monalisa Mukherjea , H. Lee Sweeney
FEBS Journal, 2012, 279 (4), pp.551-562. ⟨10.1111/j.1742-4658.2011.08449.x⟩
Journal articles hal-02349656v1
Image document

Role of Insert-1 of Myosin VI in Modulating Nucleotide Affinity

Olena Pylypenko , Lin Song , Gaelle Squires , Xiaoyan Liu , Alan B Zong
Journal of Biological Chemistry, 2011, 286 (13), pp.11716 - 11723. ⟨10.1074/jbc.m110.200626⟩
Journal articles hal-03059381v1

Essential "ankle" in the myosin lever arm

O. Pylypenko , A. Houdusse
Proceedings of the National Academy of Sciences of the United States of America, 2011, 108 (1), pp.5-6. ⟨10.1073/pnas.1017676108⟩
Journal articles hal-02349672v1
Image document

Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids

Amel Bahloul , Vincent Michel , Jean-Pierre Hardelin , Sylvie Nouaille , Sylviane Hoos
Human Molecular Genetics, 2010, 19 (18), pp.3557 - 3565. ⟨10.1093/hmg/ddq271⟩
Journal articles pasteur-03525648v1

Structural Basis for Recruitment of Rab6-Interacting Protein 1 to Golgi via a RUN Domain.

Rosario Recacha , Annick Boulet , Florence Jollivet , Solange Monier , Anne Houdusse
Structure / Struct Fold Des; Structure (Camb ), 2009, 17 (1), pp.21-30. ⟨10.1016/j.str.2008.10.014⟩
Journal articles inserm-00355625v1

The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4.

Tatiana Isabet , Guillaume Montagnac , Karine Regazzoni , Bertrand Raynal , Fatima El Khadali
EMBO Journal, 2009, 28 (18), pp.2687 - 2858. ⟨10.1038/emboj.2009.209⟩
Journal articles hal-00416785v1

Electrospray ionization mass spectrometry studies of noncovalent myosin VI complexes reveal a new specific calmodulin binding site

Guillaume Chevreux , Noelle Potier , Alain Dorsselaer , Amel Bahloul , Anne Houdusse
Journal of The American Society for Mass Spectrometry, 2005, 16 (8), pp.1367-1376. ⟨10.1016/j.jasms.2005.03.023⟩
Journal articles hal-02981194v1

The unique insert in myosin VI is a structural calcium-calmodulin binding site

A. Bahloul , G. Chevreux , A. Wells , Davy Martin , J. Nolt
Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (14), pp.4787-4792. ⟨10.1073/pnas.0306892101⟩
Journal articles hal-02981195v1
Image document

Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1)

Gaël Ménasché , Chen Hsuan Ho , Ozden Sanal , Jerome Feldmann , Ilhan Tezcan
Journal of Clinical Investigation, 2003, 112 (3), pp.450-456. ⟨10.1172/JCI18264⟩
Journal articles inserm-02440362v1

Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients

Gaël Ménasché , Jerome Feldmann , Anne Houdusse , Catherine Desaymard , Alain Fischer
Blood, 2003, 101 (7), pp.2736-2742. ⟨10.1182/blood-2002-09-2789⟩
Journal articles inserm-02440369v1
Image document

Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients

Gaël Ménasché , Jérôme Feldmann , Anne Houdusse , Catherine Desaymard , Alain Fischer
Blood, 2003, 101, pp.2736 - 2742. ⟨10.1182/blood-2002-09-2789⟩
Journal articles hal-03059374v1

Three-dimensional structure of a heteroclitic antigen-antibody cross-reaction complex.

Véronique Chitarra , Pedro M. Alzari , Graham A. Bentley , T. Narayana Bhat , Jean-Luc Eiselé
Proceedings of the National Academy of Sciences of the United States of America, 1993, 90 (16), pp.7711-7715. ⟨10.1073/pnas.90.16.7711⟩
Journal articles pasteur-03136514v1

Three-dimensional structure and antigen binding specificity of antibodies

D. Tello , S. Spinelli , H. Souchon , F.A. Saul , M.M. Riottot
Biochimie, 1990, 72 (8), pp.507-512. ⟨10.1016/0300-9084(90)90114-v⟩
Journal articles pasteur-03136462v1

Myosin Structures.

H Lee Sweeney , Anne Houdusse , Julien Robert-Paganin , H. Lee Sweeney
Myosins - A Superfamily of Molecular Motors, 1239, pp.7-19, 2020, ⟨10.1007/978-3-030-38062-5_2⟩
Book sections hal-03053363v1

Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design

Dihia Moussaoui , James Robblee , Daniel Auguin , Fabio Fisher , Patricia Fagnant
2022
Preprints, Working Papers, ... hal-03811821v1
Image document

Nucleotide-free structures of Kif20A illuminate the atypical allostery in this mitotic kinesin-6

Fanomezana Moutse Ranaivoson , Vincent Crozet , Matthieu P.M.H. Benoît , Amna Abdalla Mohammed Khalid , Carlos Kikuti
2022
Preprints, Working Papers, ... hal-03872652v1
Image document

Structure of Full Length Plasmodium Myosin A and its light chain PfELC, dual targets against malaria parasite pathogenesis

Dihia Moussaoui , James P Robblee , Daniel Auguin , Elena B Krementsova , Silvia Haase
2020
Preprints, Working Papers, ... hal-03059369v1

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

Julien Robert-Paganin , Daniel Auguin , Anne Houdusse
2020
Preprints, Working Papers, ... hal-03053365v1
Image document

Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition

Julien Robert-Paganin , Daniel Auguin , Anne Houdusse
2020
Preprints, Working Papers, ... hal-03059367v1
Image document

Structure of Full Length Plasmodium Myosin A and its light chain PfELC, dual targets against malaria parasite pathogenesis

Dihia Moussaoui , James P Robblee , Daniel Auguin , Elena B Krementsova , Silvia Haase
2020
Preprints, Working Papers, ... hal-03059395v1

Structure of Full Length Plasmodium Myosin A and its light chain PfELC, dual targets against malaria parasite pathogenesis

Dihia Moussaoui , James Robblee , Daniel Auguin , Elena Krementsova , Silvia Haase
2020
Preprints, Working Papers, ... hal-03053364v1