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Anne Lespine

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P-Glycoproteins 6 and 9 role in ivermectin resistance in the nematode model Caenorhabditis elegans

Clara Blancfuney , Marie Garcia , Anne Lespine , Mélanie Alberich
International Congress of the European Association for Veterinary Pharmacology and Toxicology, Jul 2023, Bruges, Belgium
Conference poster hal-04166911v1
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Effect of sainfoin (Onobrychis viciifolia) on cyathostomin eggs excretion, larval development, larval community structure and efficacy of ivermectin treatment in horses

Joshua Malsa , Elise Courtot , Michel Boisseau , Bertrand Dumont , Pascale Gombault
Journées d’Animation Scientifique du Département Santé Animale (JAS SA), Oct 2022, Anglet, France.
Conference poster hal-03847631v1

Selected resistance to macrocyclic lactone exhibit modulation of amphid structure and function at genetic level

Cécile Menez , Cristina Ballesteros , Ludmel Urdaneta-Marquez , Roger K. Prichard , Anne Lespine
Molecular Anthelmintics: from Discovery to Resistance, Feb 2020, santa monica, United States
Conference poster hal-02958028v1

Le récepteur nucléaire NRH-8 : une nouvelle cible pour augmenter l’efficacité de l’ivermectine chez les nématodes

Cécile Ménez , Mélanie Alberich , Elise Courtot , Sylvie Dervins , Fabrice Guégnard
Journées d'Animation Scientifique du Département Santé Animale, Oct 2018, Nantes, France. , 2018, Santé Animale et Santé Publique
Conference poster hal-02734278v1

Resistance to macrocyclic lactones: Is there a fitness cost of acquired tolerance to ivermectin and moxidectin in Caenorhabditis elegans?

Cécile Menez , Dalia Kansoh , Jean-Francois Sutra , Anne Lespine
Molecular Anthelmintics: from Discovery to Resistance, Feb 2016, San Diego, United States
Conference poster hal-02958055v1

In vitro comparison of the effect of flavonoids in anthelmintic resistant and susceptible isolates of Haemonchus contortus: preliminary results

Guillaume Salle Sallé , Cédric Neveu , Herve Hoste , Anne Lespine
BSP Bristol 2013, Apr 2013, Bristol, United Kingdom. 156 p., 2013
Conference poster hal-02746557v1

Médicaments antiparasitaires et ABC transporteurs

Solange Kiki-Mvouaka , M Alvinerie , Anne Lespine
Journées d’Animation Scientifique du Département Santé Animale, 2009, Port d'Albret, France. pp.Inconnu, 2009
Conference poster hal-02814455v1

Modulation des ABC transporteurs par les lactones macrocycliques : implication des récepteurs nucléaires ?

Cécile Menez-Berlioz , Laila Mselli-Lakhal , M Alvinerie , Anne Lespine
Journées d’Animation Scientifique du Département Santé Animale, 2009, Port d'Albret, France. pp.Inconnu, 2009
Conference poster hal-02815467v1

Interaction of the anthelmintic ivermectin with breast-cancer resistant protein (BCRP)

Anne Lespine , E Kis , T Nagy , Jacques Dupuy , S Orlowski
FEBS-ABC2008 Meeting, 2008, Innsbruck, Austria. pp.Inconnu, 2008
Conference poster hal-02818058v1

P-gp interfering agents potentiate ivermectin susceptibility in nematode ivermectin-resistant strains

Anne Lespine , D Bartley , Jacques Dupuy , M Alvinerie , Frank Jackson
21st International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), 2007, Ghent, Belgium. pp.Inconnu, 2007
Conference poster hal-02816515v1

Differences between ivermectin and moxidectin related to their affinities for multidrug resistance proteins (MRP1, 2 and 3)

Anne Lespine , Jacques Dupuy , Peter Krajcsi , M Alvinerie
International Society of the Study of Xenobiotics, 2006, Manchester, United Kingdom. pp.Inconnu, 2006
Conference poster hal-02816155v1

Role of he P-glycoprotein in the cellular efflux of the mocrcyclic lactones (MLs) Influence of interfering agents

Anne Lespine , J Dupuis , Alain Roulet , Thierry Pineau , M Alvinerie
EU-FEBS Conference, 2004, Copenhagen, Denmark. pp.Inconnu, 2004
Conference poster hal-02828610v1

Putative prediction of macrocyclic lactones in vivo-disposition using an original pharmacological parameter (Vp50) obtained from transport experiments in P-glycoprotein-expressing cells

Alain Roulet , Alain Bousquet‐mélou , Didier Concordet , Jacques Dupuy , Anne Lespine
19th International Conference of the World Association for the Advancement of Veterinary Parasitology, 2003, New Orleans, United States. pp.Inconnu, 2003
Conference poster hal-02829746v1
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Filarial DAF-12 sense the host serum to resume iL3 development during infection

Rémy Bétous , Anthony Emile , Hua Che , Eva Guchen , Didier Concordet
PLoS Pathogens, 2023, 19 (6), pp.e1011462. ⟨10.1371/journal.ppat.1011462⟩
Journal articles hal-04169441v1
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Lack of efficacy of topical administration of eprinomectin against gastrointestinal nematode in a French dairy sheep farm: A case of underexposure of worms

Léa Bordes , Denis Ticoulet , Jean-François Sutra , Anne Lespine , Philippe Jacquiet
Veterinary Record Case Reports, 2022, 10, pp.e435. ⟨10.1002/vrc2.435⟩
Journal articles hal-03832199v1
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Genetic polymorphism, constitutive expression and tissue localization of Dirofilaria immitis P-glycoprotein 11: a putative marker of macrocyclic lactone resistance

Emily Curry , Roger Prichard , Anne Lespine
Parasites & Vectors, 2022, 15 (1), pp.482. ⟨10.1186/s13071-022-05571-6⟩
Journal articles hal-04019855v1
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Effect of sainfoin ( Onobrychis viciifolia ) on cyathostomin eggs excretion, larval development, larval community structure and efficacy of ivermectin treatment in horses

Joshua Malsa , Elise Courtot , Michel Boisseau , Bertrand Dumont , Pascale Gombault
Parasitology, 2022, 149 (11), pp.1439-1449. ⟨10.1017/S0031182022000853⟩
Journal articles hal-03753744v1
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A device to simulate contaminant transfer and surface and subsurface flow through intact soil monoliths

Nico Hachgenei , Guillaume Nord , Lorenzo Spadini , Henri Mora , François Courvoisier
Vadose Zone Journal, 2022, 21 (2), ⟨10.1002/vzj2.20184⟩
Journal articles hal-03715127v1
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Ivermectin as a potential treatment for COVID-19?

Olivier Chosidow , Charlotte Bernigaud , Didier Guillemot , Bruno Giraudeau , Anne Lespine
PLoS Neglected Tropical Diseases, 2021, 15 (6), pp.e0009446. ⟨10.1371/journal.pntd.0009446⟩
Journal articles hal-03246642v1

A Large Impact of Obesity on the Disposition of Ivermectin, Moxidectin and Eprinomectin in a Canine Model: Relevance for COVID-19 Patients

Alain Bousquet-Mélou , Anne Lespine , Jean-François Sutra , Isabelle Bargues , Pierre-Louis Toutain
Frontiers in Pharmacology, 2021, 12, ⟨10.3389/fphar.2021.666348⟩
Journal articles hal-03260114v1
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Ivermectin treatment in lactating mares results in suboptimal ivermectin exposure in their suckling foals

Ghismon-De-Kasin Mayinda , Delphine Serreau , Amandine Gesbert , Fabrice Reigner , Jean-François Sutra
Veterinary Parasitology, 2021, 296, 5 p. ⟨10.1016/j.vetpar.2021.109511⟩
Journal articles hal-03282424v1

Serious Ivermectin Toxicity and Human ABCB1 Nonsense Mutations

Eloise Baudou , Anne Lespine , Geneviève Durrieu , François André , Peggy Gandia
New England Journal of Medicine, 2020, 383 (8), pp.787--789. ⟨10.1056/NEJMc1917344⟩
Journal articles hal-02928174v1

P-glycoprotein (ABCB1) is involved in vitamin K efflux

Marielle Margier , Cedric Le May , Tiffany Antoine , Charlotte Halimi , Marion Nowicki
Food Chemistry, 2020, 343, pp.1-5. ⟨10.1016/j.foodchem.2020.128510⟩
Journal articles hal-03012693v1
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First report of multiple resistance to eprinomectin and benzimidazole in Haemonchus contortus on a dairy goat farm in France

Léa Bordes , Nicolas Dumont , Anne Lespine , Elise Souil , Jean-François Sutra
Parasitology International, 2020, 76, pp.102063. ⟨10.1016/j.parint.2020.102063⟩
Journal articles hal-03464522v1
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The development of the dog heartworm is highly sensitive to sterols which activate the orthologue of the nuclear receptor DAF‑12.

Thavy Long , Mélanie Alberich , François André , Cécile Menez , Roger K Prichard
Scientific Reports, 2020, 10 (1), pp.11207. ⟨10.1038/s41598-020-67466-9⟩
Journal articles hal-02957764v1
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ABCB1 (P-glycoprotein) regulates vitamin D absorption and contributes to its transintestinal efflux

Marielle Margier , Xavier Collet , Cédric Le May , Charles Desmarchelier , François André
FASEB Journal, 2019, 33 (2), pp.2084-2094. ⟨10.1096/fj.201800956R⟩
Journal articles hal-01986017v1
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The transcription factor NHR-8: A new target to increase ivermectin efficacy in nematodes

Cécile Ménez , Mélanie Alberich , Elise Courtot , Fabrice Guégnard , Alexandra Blanchard
PLoS Pathogens, 2019, 15 (2), 31 p. ⟨10.1371/journal.ppat.1007598⟩
Journal articles hal-02628877v1

Assessment of the long-acting ivermectin formulation in sheep: Further insight into potential pharmacokinetic interactions

Mariana Ballent , Maria Laura Maté , Paula Dominguez , Guillermo Virkel , Mélanie Alberich
Journal of Veterinary Pharmacology and Therapeutics, 2019, 42 (2), pp.189-196. ⟨10.1111/jvp.12739⟩
Journal articles hal-02618035v1

Scabies in an obese patient: How should the ivermectin dosing be adapted?

G Mellon , L Hermet , Pierre-Louis Toutain , A Dulioust , Anne Lespine
Médecine et Maladies Infectieuses, 2019, 49 (4), pp.286-288. ⟨10.1016/j.medmal.2018.09.007⟩
Journal articles hal-02618679v1
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Structural model, functional modulation by ivermectin and tissue localization of Haemonchus contortus P-glycoprotein-13

Marion David , Chantal Lebrun , Thomas Duguet , Franck Talmont , Robin Beech
International journal for parasitology. Drugs and drug resistance, 2018, 8 (1), pp.145--157. ⟨10.1016/j.ijpddr.2018.02.001⟩
Journal articles hal-02177610v1
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Efficacy and pharmacokinetics evaluation of a single oral dose of afoxolaner against Sarcoptes scabiei in the porcine Scabies model for human infestation

Charlotte Bernigaud , Fang Fang , Katja Fischer , Anne Lespine , Ludwig S. Aho
Antimicrobial Agents and Chemotherapy, 2018, 62 (9), ⟨10.1128/AAC.02334-17⟩
Journal articles hal-02627327v1
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P-glycoproteins play a role in ivermectin resistance in cyathostomins

L.E. Peachey , G.L. Pinchbeck , J.B. Matthews , F.A. Burden , Anne Lespine
International journal for parasitology. Drugs and drug resistance, 2017, 7 (3), pp.388-398. ⟨10.1016/j.ijpddr.2017.10.006⟩
Journal articles hal-02620683v1
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Cross-resistance to moxidectin and ivermectin on a meat sheep farm in France

Carine Paraud , T. Marcotty , Anne Lespine , Jean-Francois Sutra , I. Pors
Veterinary Parasitology, 2016, 226, pp.88-92. ⟨10.1016/j.vetpar.2016.06.033⟩
Journal articles hal-02633599v1
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Preclinical study of single-dose moxidectin, a new oral treatment for scabies: Efficacy, safety, and pharmacokinetics compared to two-Ddose Iiermectin in a porcine model

Charlotte Bernigaud , Fang Fang , Katja Fischer , Anne Lespine , Ludwig Serge Aho
PLoS Neglected Tropical Diseases, 2016, 10 (10), ⟨10.1371/journal.pntd.0005030⟩
Journal articles hal-01608099v1

Acquired tolerance to ivermectin and moxidectin after drug selection pressure in the nematode Caenorhabditis elegans

Cécile Menez , Mélanie Alberich , Dalia Kansoh , Alexandra Blanchard , Anne Lespine
Antimicrobial Agents and Chemotherapy, 2016, 60 (8), pp.4809-4819. ⟨10.1128/AAC.00713-16⟩
Journal articles hal-02634646v1

Efficacy of sainfoin (Onobrychis viciifolia) pellets against multi resistant Haemonchus contortus and interaction with oral ivermectin: Implications for on-farm control

Elodie Gaudin , Margaux Simon , Jessica Quijada , Francois F. Schelcher , Jean-Francois Sutra
Veterinary Parasitology, 2016, 227, pp.122-129. ⟨10.1016/j.vetpar.2016.08.002⟩
Journal articles hal-02633792v1
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In silico analysis of the binding of anthelmintics to Caenorhabditis elegansP-glycoprotein 1.

Marion A. David , Stéphane Orlowski , Roger K. Prichard , Shaima Hashem , François André
International journal for parasitology. Drugs and drug resistance, 2016, 6 (3), pp.299-313. ⟨10.1016/j.ijpddr.2016.09.001⟩
Journal articles hal-01451654v1

Kinetics and anthelmintic efficacy of topical eprinomectin when given orally to goats

Chloé Badie , Anne Lespine , Jacques Devos , Jean-Francois Sutra , Christophe Chartier
Veterinary Parasitology, 2015, 209 (1-2), pp.56-61. ⟨10.1016/j.vetpar.2015.02.013⟩
Journal articles hal-02637782v1
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Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions

Andrew C. Kotze , Peter W. Hunt , Philip Skuce , Georg von Samson-Himmelstjerna , Richard J. Martin
International Journal for Parasitology, 2014, 4 (3), pp.164-184. ⟨10.1016/j.ijpddr.2014.07.007⟩
Journal articles hal-02639668v1

Ivermectin exposure leads to up-regulation of detoxification genes in vitro and in vivo in mice

Mélanie Alberich , Cécile Menez , Jean-Francois Sutra , Anne Lespine
European Journal of Pharmacology, 2014, 740, pp.428 - 435. ⟨10.1016/j.ejphar.2014.06.052⟩
Journal articles hal-02634112v1

Persistent coma in Strongyloides hyperinfection syndrome associated with persistently increased ivermectin levels

David J. van Westerloo , Gijs W. Landman , Roger Prichard , Anne Lespine , Leo G. Visser
Clinical Infectious Diseases, 2014, 58 (1), pp.143-144. ⟨10.1093/cid/cit656⟩
Journal articles hal-02634358v1

Lipid-like properties and pharmacology of the anthelmintic macrocyclic lactones

Anne Lespine
Expert Opinion on Drug Metabolism and Toxicology, 2013, 9 (12), pp.1581-1595. ⟨10.1517/17425255.2013.832200⟩
Journal articles hal-02646036v1

Transintestinal Cholesterol Excretion Is an Active Metabolic Process Modulated by PCSK9 and Statin Involving ABCB1

Cedric Le May , Jean Mathieu Berger , Anne Lespine , Bruno Pillot , Xavier Prieur
Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33 (7), pp.1484-1493. ⟨10.1161/ATVBAHA.112.300263⟩
Journal articles hal-03013326v1
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Exposition alimentaire aux pesticides seuls ou en mélange : caractérisation métabolique et impact sur la barrière intestinale

Métais Benjamin , Edwin Fouché , Anne Lespine , Anne Galinier , Sutra Jean-François
Innovations Agronomiques, 2013, 28, pp.49-57. ⟨10.17180/f0k6-he23⟩
Journal articles hal-04537730v1

Transintestinal Cholesterol Excretion Is an Active Metabolic Process Modulated by PCSK9 and Statin Involving ABCB1

Cedric Le May , Jean Mathieu Berger , Anne Lespine , Bruno Pillot , Xavier Prieur
Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33 (7), pp.1484 - 1493. ⟨10.1161/ATVBAHA.112.300263⟩
Journal articles hal-02650431v1

Characterisation of macrocyclic lactone resistance in two field-derived isolates of Cooperia oncophora

Dj Bartley , C.L Mcarthur , L.M Devin , Jean-Francois Sutra , A.A Morrison
Veterinary Parasitology, 2012, 190 (3-4), pp.454-460. ⟨10.1016/j.vetpar.2012.07.022⟩
Journal articles hal-02652074v1
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P-glycoproteins and other multidrug resistance transporters in the pharmacology of anthelmintics: Prospects for reversing transport-dependent anthelmintic resistance

Roger K. Prichard , Cécile Menez-Berlioz , Anne Lespine
International journal for parasitology. Drugs and drug resistance, 2012, 2, pp.58 - 75. ⟨10.1016/j.ijpddr.2011.10.001⟩
Journal articles hal-02645017v1
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Ivermectin induces P-glycoprotein expression and function through mRNA stabilization in murine hepatocyte cell line

Cécile Menez-Berlioz , Laila Mselli-Lakhal , Magali Vignault-Foucaud , Patrick Balaguer , Roger Alvinerie
Biochemical Pharmacology, 2012, 83 (2), pp.269-278. ⟨10.1016/j.bcp.2011.10.010⟩
Journal articles hal-01191347v1
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Moxidectin and the avermectins: Consanguinity but not identity

Roger Prichard , Cécile Menez-Berlioz , Anne Lespine
International journal for parasitology. Drugs and drug resistance, 2012, 2, pp.134 - 153. ⟨10.1016/j.ijpddr.2012.04.001⟩
Journal articles hal-02649069v1
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Relative Neurotoxicity of Ivermectin and Moxidectin in Mdr1ab (-/-) Mice and Effects on Mammalian GABA(A) Channel Activity

Cécile Menez-Berlioz , Jean-Francois Sutra , Roger Prichard , Anne Lespine
PLoS Neglected Tropical Diseases, 2012, 6 (11), ⟨10.1371/journal.pntd.0001883⟩
Journal articles hal-02644560v1

Endectocides in goats: pharmacology, efficacy and use conditions in the context of anthelmintic resistance

Anne Lespine , Christophe Chartier , Herve Hoste , Roger Alvinerie
Small Ruminant Research, 2012, 103 (1), pp.10-17. ⟨10.1016/j.smallrumres.2011.10.013⟩
Journal articles hal-02651501v1
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Influence of Pluronic 85 and ketoconazole on disposition and efficacy of ivermectin in sheep infected with a multiple resistant Haemonchus contortus isolate

Dj Bartley , A.A Morrison , Jacques Dupuy , Y Bartley , Jean-Francois Sutra
Veterinary Parasitology, 2012, 187 (3-4), pp.464-472. ⟨10.1016/j.vetpar.2012.02.011⟩
Journal articles hal-01222889v1
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P-glycoprotein Dysfunction Contributes to Hepatic Steatosis and Obesity in Mice

Magali Vignault-Foucaud , Zeina Soayfane , Cécile Menez-Berlioz , Justine Bertrand-Michel , Pascal Guy
PLoS ONE, 2011, 6 (9), ⟨10.1371/journal.pone.0023614⟩
Journal articles hal-02650319v1
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Ivermectin Interacts With Human ABCG2

Marton Jani , Ildiko Makai , Emese Kis , Pal Szabo , Tunde Nagy
Journal of Pharmaceutical Sciences, 2011, 100 (1), pp.94-97. ⟨10.1002/jps.22262⟩
Journal articles hal-02645949v1
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P-glycoprotein Dysfunction Contributes to HepaticSteatosis and Obesity in Mice

Magali Vignault-Foucaud , Zeina Soayfane , Cécile Menez-Berlioz , Justine Bertrand-Michel , Pascal G.P. Martin
PLoS ONE, 2011, 6 (9), pp.e23614
Journal articles hal-01137178v1

Interaction of anthelmintic drugs with P-glycoprotein in recombinant LLC-PK1-mdr1a cells

Jacques Dupuy , Michel Alvinerie , Cécile Menez , Anne Lespine
Chemico-Biological Interactions, 2010, 186 (3), pp.280-286. ⟨10.1016/j.cbi.2010.05.013⟩
Journal articles hal-02663660v1

Role of P-Glycoprotein in the Disposition of Macrocyclic Lactones: A Comparison between Ivermectin, Eprinomectin, and Moxidectin in Mice

Solange Kiki-Mvouaka , Cécile Menez , Christiane Borin , Faouzi Lyazrhi , Magali Vignault-Foucaud
Drug Metabolism and Disposition, 2010, 38 (4), pp.573-580. ⟨10.1124/dmd.109.030700⟩
Journal articles hal-02663207v1

Influence of obesity on the pharmacokinetics of anthelmintic macrocyclic lactones in dogs

I Bargues , Anne Lespine , Pierre-Louis Toutain , Alain Bousquet‐mélou
Journal of Veterinary Pharmacology and Therapeutics, 2009, 32 (s1), pp.161-162
Journal articles hal-02654350v1

P-glycoprotein interfering agents potentiate ivermectin susceptibility in ivermectin sensitive and resistant isolates of Teladorsagia circumcincta and Haemonchus contortus

D.J. Bartley , H. Mcallister , Y. Bartley , Jacques Dupuy , Cécile Menez-Berlioz
Parasitology, 2009, 136 (9), pp.1081-1088. ⟨10.1017/S0031182009990345⟩
Journal articles hal-02662392v1

Interaction of macrocyclic lactones with the multidrug transporters: The bases of the pharmacokinetics of lipid-like drugs

Anne Lespine , Jacques Dupuy , M Alvinerie , Christine Coméra , T Nagy
Current Drug Metabolism, 2009, 10 (3), pp.272-288
Journal articles hal-02655821v1

Pharmacologie et efficacité des endectocides chez les caprins

C Chartier , Anne Lespine , Herve Hoste , M.A Alvinerie
Bulletin des G.T.V., 2008, 44, pp.119-124
Journal articles hal-02654601v1

Ketoconazole increases the plasma levels of ivermectin in sheep

Roger Alvinerie , Jacques Dupuy , Solange Kiki-Mvouaka , Jf Sutra , Anne Lespine
Veterinary Parasitology, 2008, 157 (1-2), pp.117-122. ⟨10.1016/j.vetpar.2008.06.017⟩
Journal articles hal-02658693v1

Les endectocides chez les caprins : pharmacologie, efficacité et conditions d'utilisation dans le contexte de la résistance aux anthelminthiques

C Chartier , Anne Lespine , Herve Hoste , M Alvinerie
Bulletin des G.T.V., 2008, pp.Inconnu
Journal articles hal-02654687v1

ABC transporter modulation: a strategy to enhance the activity of macrocyclic lactone anthelmintics

Anne Lespine , Roger Alvinerie , Jozef Vercruysse , Roger K. Prichard , Peter Geldhof
Trends in Parasitology, 2008, 24 (7), pp.293-298. ⟨10.1016/j.pt.2008.03.011⟩
Journal articles hal-02662487v1
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Multiple oral dosing of ketoconazole increases dog exposure to ivermectin

C Hugnet , Anne Lespine , Roger Alvinerie
Journal of Pharmacy and Pharmaceutical Sciences, 2007, 10 (3), pp.311-318
Journal articles hal-02655765v1

Interaction of macrocyclic lactones with P-glycoprotein : Structure - affinity relationship Eur

Anne Lespine , S. Martin , J. Dupuy , A. Roulet , T. Pineau
Journal of Pharmaceutical Sciences, 2007, pp.84-94
Journal articles hal-00207662v1

Estimation of absolute oral bioavailability of moxidectin in dogs using a semi-simultaneous method: influence of lipid co-administration.

Elodie Lallemand , Anne Lespine , Michel Alvinerie , Alain Bousquet‐mélou , Pierre-Louis Toutain
Journal of Veterinary Pharmacology and Therapeutics, 2007, 30 (5), pp.375-80. ⟨10.1111/j.1365-2885.2007.00878.x⟩
Journal articles hal-00517557v1

Interaction of macrocyclic lactones with P-glycoprotein: Structure-affinity relationship

Anne Lespine , Sylvie Martin , Jacques Dupuy , Alain Roulet , Thierry Pineau
European Journal of Pharmaceutical Sciences, 2007, 30 (1), pp.84-94. ⟨10.1016/j.ejps.2006.10.004⟩
Journal articles hal-02668370v1

Fumagillin, a new P-glycoprotein-interfering agent able to modulate moxidectin efflux in rat hepatocytes

Jacques Dupuy , Anne Lespine , Jean-Francois Sutra , Roger Alvinerie
Journal of Veterinary Pharmacology and Therapeutics, 2006, 29 (6), pp.489-494
Journal articles hal-02655459v1

Assessment of a liposomal formulation of ivermectin in rabbit after a single subcutaneous administration

Mohamad Firas Bassissi , Anne Lespine , Roger Alvinerie
Parasitology Research, 2006, 98 (3), pp.244-249. ⟨10.1007/s00436-005-0073-z⟩
Journal articles hal-02659880v1

Interaction of ivermectin with multidrug resistance proteins (MRP1, 2 and 3)

Anne Lespine , Jacques Dupuy , S Orlowski , T Nagy , H Glavinas
Chemico-Biological Interactions, 2006, 159 (3), pp.169-179. ⟨10.1016/j.cbi.2005.11.002⟩
Journal articles hal-02661667v1

The interaction between moxidectin and MDR transporters in primary cultures of rat hepatocytes

Jacques Dupuy , Anne Lespine , Jf Sutra , M Alvinerie
Journal of Veterinary Pharmacology and Therapeutics, 2006, 29 (2), pp.107-111
Journal articles hal-02661548v1

Contribution of lymphatic transport to the systemic exposure of orally administered moxidectin in conscious lymph duct-cannulated dogs.

Anne Lespine , Guillaume Chanoit , Alain Bousquet‐mélou , Elodie Lallemand , Firas Mohamad Bassissi
European Journal of Pharmaceutical Sciences, 2006, 27 (1), pp.37-43. ⟨10.1016/j.ejps.2005.08.003⟩
Journal articles hal-00517563v1

Influence of dyslipidemia on moxidectin distribution in plasma lipoproteins and on its pharmacokinetics

Mf Bassissi , Roger Alvinerie , Pgp Martin , B Perret , Anne Lespine
Pharmaceutical Research, 2006, 23 (11), pp.2672-2680. ⟨10.1007/s11095-006-9114-2⟩
Journal articles hal-02658696v1

Influence of the route of administration on efficacy and tissue distribution of ivermectin in goat

Anne Lespine , M Alvinerie , Jf Sutra , I Pors , C Chartier
Veterinary Parasitology, 2005, 128 (3-4), pp.251-260. ⟨10.1016/j.vetpar.2004.11.028⟩
Journal articles hal-02683370v1

Efficacy of eprinomectin pour-on against gastrointestinal nematodes and the nasal bot fly (Oestrus ovis) in sheep

Herve Hoste , Anne Lespine , P Lemercier , M Alvinerie , Philippe P. Jacquiet
Veterinary Record, 2004, 154 (25), pp.782-785
Journal articles hal-02672817v1

The influence of parasitism on the pharmacokinetics of moxidectin in lambs

Anne Lespine , Jf Sutra , Jacques Dupuy , M Alvinerie , Gilles Aumont
Parasitology Research, 2004, 93 (2), pp.121-126. ⟨10.1007/s00436-004-1084-x⟩
Journal articles hal-02680452v1

The influence of parasitism on the pharmacokinetics of moxidectin in lambs

Anne Lespine , J.F. Sutra , J. Dupuy , M. Alvinerie , Gilles Aumont
Parasitology Research, 2004, 93, pp.121-126
Journal articles hal-02669260v1

Macrocyclic lactones: distribution in plasma lipoproteins of several animal species including humans

Mf Bassissi , Roger Alvinerie , Anne Lespine
Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology, 2004, 138 (4), pp.437-444. ⟨10.1016/j.cca.2004.07.011⟩
Journal articles hal-02680351v1

Enhancement of oral moxidectin bioavailability in rabbits by lipid co-administration

Mohamad Firas Bassissi , Anne Lespine , Roger Alvinerie
Parasitology Research, 2004, 94 (3), pp.188-192. ⟨10.1007/s00436-004-1192-7⟩
Journal articles hal-02679907v1

Efficacy of injectable and pour-on microdose ivermectin in the treatment of goat warble fly infestation by Przhevalskiana silenus (Diptera, Oestridae)

A. Giangaspero , M. Alvinerie , D. Traversa , B. Paoletti , Anne Lespine
Veterinary Parasitology, 2003, 116, pp.333-343
Journal articles hal-02680122v1

Pharmacokinetics of ivermectin in the yak (Bos grunniens)

Jacques Dupuy , H. Yin , J.X. Luo , D.Y. Yang , G.Q. Guan
Veterinary Parasitology, 2003, 117, pp.153-157. ⟨10.1016/j.vetpar.2003.07.025⟩
Journal articles hal-02681891v1

Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: quercetin

Jacques Dupuy , G Larrieu , Jf Sutra , Anne Lespine , M Alvinerie
Veterinary Parasitology, 2003, 112 (4), pp.337-347. ⟨10.1016/S0304-4017(03)00008-6⟩
Journal articles hal-02683396v1

The comparative serum disposition kinetics of subcutaneous administration of doramectin, ivermectin and moxidectin in the Australian Merino sheep

S Barber , V Bowles , Anne Lespine , Roger Alvinerie
Journal of Veterinary Pharmacology and Therapeutics, 2003, 26 (5), pp.343-348
Journal articles hal-02675599v1

Eprinomectin in goat: assessment of subcutaneous administration

Anne Lespine , Jean-Francois Sutra , Jacques Dupuy , Roger Alvinerie
Parasitology Research, 2003, 89 (2), pp.120-122. ⟨10.1007/s00436-002-0727-z⟩
Journal articles hal-02680249v1

O75 | Pharmacodynamic and phenotypic evaluation of eprinomectin resistant Haemonchus isolates from French dairy sheep farms

Anne Lespine , Sophie Jouffroy , J. Petterman , Marie Garcia , Christelle Grisez
15th International Congress of the European Association for Veterinary Pharmacology and Toxicology, European Association of Veterinary Pharmacology and Toxicology (EAVPT), Jul 2023, Bruges, Belgium. pp.65-65, ⟨10.1111/jvp.13241⟩
Conference papers hal-04181004v1

Anthelmintic Fluorescent drugs, new probes to detect anthelmintic resistance in the nematode Caenorhabditis elegans

Mélanie Alberich , Jean-Francois Sutra , Marlène Z Lacroix , Anne Lespine
WAAVPT 2021, Jul 2021, Dublin (Online), France
Conference papers hal-04169554v1

The transcription factor NHR-8 is involved in ivermectin tolerance in the model nematode Caenorhabditis elegans and in the strongylid nematode Haemonchus contortus

Cécile Menez , Mélanie Alberich , Elise Courtot , Alexandra Blanchard , Hugo Aguilaniu
anthelmintics: Discovery to resistance, Jan 2018, Clearwater, United States
Conference papers hal-02929481v1

The transcription factor NHR-8 is involved in ivermectin tolerance in the model nematode Caenorhabditis elegans and in the strongylid nematode Haemonchus contortus

Cécile Ménez , Mélanie Alberich , Elise Courtot , Anne Lespine
26. International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP 2017), The Malaysian Society of Parasitology & Tropical Medicine (MSPTM)., Sep 2017, Kuala Lumpur, Malaysia
Conference papers hal-02736808v1

Discovery of a new factor involved in ivermectin tolerance in the model nematode Caenorhabditis elegans and in the strongylid nematode Haemonchus contortus.

Cécile Menez , Mélanie Alberich , Elise Courtot , Anne Lespine
Molecular Helminthology: An Integrated Approach, Mar 2017, Cap Cod, United States
Conference papers hal-02957851v1

ABCB1 is involved in vitamin D intestinal efflux

Marielle Margier , Charles Desmarchelier , Alice Bluteau , André Collet , Patrick Borel
16. Fat Soluble Vitamins (FSV) congress, Société Française des Vitamines et Biofacteurs (SFVB). FRA., Mar 2017, Paris, France. 130 p
Conference papers hal-01517923v1

Comparison of ivermectin and moxidectin resistance profiles in the nematode Caenorhabditis elegans

Cécile Menez , Dalia Kansoh , Jean-Francois Sutra , Anne Lespine
International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP 2015), Aug 2015, liverpool, United Kingdom
Conference papers hal-02929510v1

Comparative pharmacodynamics and pharmacokinetics of moxidectin and ivermectin endectocides: a brief update

R. K. Prichard , Anne Lespine , Cécile Menez
12. International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT 2012), Jul 2012, Noordwijkerhout, Netherlands. 182 p
Conference papers hal-02748125v1

Chronic administration of ivermectin leads to a decrease of its concentration in the host

Mélanie Alberich , Cécile Menez , Anne Lespine
12. International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT 2012), Jul 2012, Noordwijkerhout, Netherlands. 182 p
Conference papers hal-02748957v1

Differential neurotoxicity of ivermectin and moxidectin in mammals

Cécile Menez , Jean-Francois Sutra , R. K. Prichard , Anne Lespine
12. International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT 2012), Jul 2012, Noordwijkerhout, Netherlands. 182 p
Conference papers hal-02748121v1

Interaction of anthelminthics with ABC transporters

Anne Lespine
Symposium on Membrane Ion Channels in Helminth Parasites, Resistance and Site of Action for Anthelmintics, Saisissez le nom du laboratoire, du service ou du département., Ville service., Dec 2011
Conference papers hal-02803051v1

Optimizing anthelmintic combinations to counter anthelmintic resistance

Anne Lespine
Conference of the World Association for the Advancement of Veterinary Parasitology, Saisissez le nom du laboratoire, du service ou du département., Ville service., Aug 2011, Buenos Aires, Argentina
Conference papers hal-02802149v1

Pharmacocinétique de l'éprinomectine chez les souris déficientes en P-gp : comparaison avec l'ivermectine et la moxidectine

Solange Kiki-Mvouaka , Christiane Borin , Magali Vignault-Foucaud , Cécile Menez , Christine Coméra
Journées d’Animation Scientifique du Département Santé Animale, 2009, Port d'Albret, France. pp.Inconnu
Conference papers hal-02822598v1

The anthelmintic ivermectin: a substrate of Breast-Cancer Resistant Protein (BCRP)

E Kis , Sylvaine Lecoeur , Cécile Menez , T Nagy , Jacques Dupuy
22nd World Association for the Advancement of Veterinary Parasitology Conference - WAAVP 2009, 2009, Calgary, Canada. pp.Inconnu
Conference papers hal-02821732v1

Disposition of eprinomectin in P-gp deficient mice: a comparison with ivermectin and moxidectin

Solange Kiki-Mvouaka , Christiane Borin , Magali Vignault , Cécile Menez , Christine Coméra
22nd World Association for the Advancement of Veterinary Parasitology Conference - WAAVP 2009, 2009, Calgary, Canada. pp.Inconnu
Conference papers hal-02815515v1

WP6 - Control of P-glycoprotein (Pgp) in both host and parasites for an improvement of anthelmintic treatment.

Dominique Kerboeuf , Fabrice Guégnard , Christine Koch , Yves Le Vern , Roger Alvinerie
PARASOL - Sixth framework programme of the E.U. (Project FOOD-CT-2005-022851) - Novel solutions for the sustainable control of nematodes in ruminants, 2009, Edinburgh, United Kingdom. n.p
Conference papers hal-02823130v1

Influence of obesity on the pharmacokinetics of anthelmintic macrocyclic lactones in dogs

I Bargues , Anne Lespine , Pierre-Louis Toutain , Alain Bousquet‐mélou
11th International congress of the European Association for Veterinary Pharmacology and Toxicology, 2009, Leipzig, Germany
Conference papers hal-02752015v1

Investigations into the effects of p-glycoprotein and/or cytochrom P450 inhibitors on the phenotype responses of various developmental stages of ovine nematodes

Dj Bartley , Anne Lespine , Jacques Dupuy , M Alvinerie , H Mc Allister
21st International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), 2007, Ghent, Belgium. pp.Inconnu
Conference papers hal-02814112v1

Interaction of macrocyclic lactones (MLs) with multidrug resistance transporters

Anne Lespine , M Alvinerie
21st International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), 2007, Ghent, Belgium. pp.Inconnu
Conference papers hal-02815063v1

Interaction of MLs with ABC transporters

Anne Lespine
Invited by SOLVO Biotechnology, 2006, Budapest, Hungary. pp.Inconnu
Conference papers hal-02811791v1

The role of drug transporters in the disposition of milbemycins and avermectins

M Alvinerie , Anne Lespine
EAVPT, 2006, Turin, Italy. pp.Inconnu
Conference papers hal-02815213v1

Influence of anthelmintic drugs on P-glycoprotein transport activity in mdr1-LLC-PK1 cells

Jacques Dupuy , Anne Lespine , M Alvinerie
EAVPT, 2006, Turin, Italy. pp.Inconnu
Conference papers hal-02812336v1

Differences between ivermectin and moxidectin related to their affinities for multidrug resistance proteins (MRP1, 2 and 3)

Anne Lespine , Jacques Dupuy , T Nagy , Peter Krajcsi , M Alvinerie
10e Congrès international de l’EAVPT, 2006, Turin, Italy. pp.Inconnu
Conference papers hal-02816593v1

Differences between ivermectin and moxidectin related to their affinities for multidrug resistance proteins (MRP1, 2, and 3)

Anne Lespine , Jacques Dupuy , Peter Krajcsi , M Alvinerie
Inconnu, 2006, pp.Inconnu
Conference papers hal-02814340v1

Rôle des ABC transporteurs dans le devenir des lactones macrocycliques dans l'organisme

Anne Lespine
Journées francophones sur les transporteurs ABC, 2006, Paris, France. pp.Inconnu
Conference papers hal-02811820v1

Intestinal lymphatic transport of moxidectin in conscious lymph duct-cannulated dogs

Anne Lespine , G Chanoit , Alain Bousquet‐mélou , Elodie Lallemand , F Bassissi
EUFEPS Conferences 3rd World Conference on Drug Absorption Transport and delivery, 2004, Barcelona, Spain. pp.Inconnu
Conference papers hal-02827582v1

Effect of route of administration and formulation on ivermectin bioavailability in Chinese cattle

M Alvinerie , Anne Lespine , Jacques Dupuy
INCO Project nICA42000-30036 meeting, 2004, Shangai, China. pp.Inconnu
Conference papers hal-02825390v1

Chemotherapy improvement for hypodermosis

M Alvinerie , Anne Lespine , Jacques Dupuy
INCO Project nICA42000-30036 meeting, 2004, Shangai, China. pp.Inconnu
Conference papers hal-02825185v1

Hypodermosis control : determination of dose and route of administration of ivermectin microdosis to goat

M Alvinerie , Anne Lespine , Jacques Dupuy
INCO Project nICA42000-30036 meeting, 2004, Shangai, China. pp.Inconnu
Conference papers hal-02825675v1

Influence of hypercholesterolemia on disposition of moxidectin in a rabbit model

F Bassissi , M Alvinerie , Anne Lespine
EUFEPS Conferences 3rd World Conference on Drug Absorption Transport and delivery, 2004, Barcelona, Spain. pp.Inconnu
Conference papers hal-02827470v1

Influence of the macrocyclic lactones on the P-glycoprotein function on P-gp overexpressing cells

Anne Lespine , Jacques Dupuy , Alain Roulet , Thierry Pineau
European Federation for Pharmaceutical Sciences Conference, 2004, Copenhagen, Denmark. pp.Inconnu
Conference papers hal-02830010v1

Eprinomectin in dairy goats : assessment of an optimal dosage

Anne Lespine , J Duupuy , Jf Sutra , M Alvinerie , C Chartier
8th International Conference on Goats, 2004, Pretoria, South Africa. pp.Inconnu
Conference papers hal-02825263v1

Improvement of ML's treatment by control of P-glycoprotein in the host

M Alvinerie , Anne Lespine
COST - B16, 2004, Paris, France. pp.Inconnu
Conference papers hal-02825235v1

Use of reversing agents of P-glycoprotein to increase the systematic availability of macrocyclic lactones : a promising tool

M Alvinerie , Jacques Dupuy , Jf Sutra , Anne Lespine
19th International Conference of the World Association for the Advancement of Veterinary Parasitology, 2003, New Orleans, United States. pp.Inconnu
Conference papers hal-02825262v1

Role of the P-glycoprotein in the cellular eflux of macrocyclic lactones : influence of interfering agents

Anne Lespine , Alain Roulet , Jacques Dupuy , Thierry Pineau , M Alvinerie
9th EAVPT Congress, 2003, Lisbon, Portugal. pp.Inconnu
Conference papers hal-02828145v1

Binding of ivermectin and moxidectin to the plasma lipoproteins

Anne Lespine , F Bree , F Bassissi , Jf Sutra , Jp Tillement
9th EAVPT Congress, 2003, Lisbon, Portugal. pp.Inconnu
Conference papers hal-02828011v1

Putative prediction of macrocyclic lactones in vivo-disposition using an original pharmacological parameter [Vp50] obtained from transport experiments in P-glycoprotein-expressing cells

Alain Roulet , Alain Bousquet‐mélou , Didier Concordet , Jacques Dupuy , Anne Lespine
19th International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP), 2003, New Orleans, United States. pp.Inconnu
Conference papers hal-02829726v1