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Anne Zaparucha

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Research domains

Chemical Sciences Life Sciences [q-bio]

Publications

Hybrid catalysis, assisted by machine learning, for bio-sourced molecules functionalization

Antoine Lancien , Guillaume Darlot , Jonathan Bassut , Aurélie Jouenne , Tao Jiang
Invited Seminar - University of Graz, Nov 2023, Graz, Austria
Conference papers hal-04336053v1

Diverse Amine dehydrogenases for the biocatalytic synthesis of amines

Carine Vergne-Vaxelaire , Eddy Elisée , Laurine Ducrot , Ombeline Mayol , Raphael Meheust
ENZYNOV'2, Oct 2023, Paris-Romainville, France
Conference papers hal-04327765v1
Image document

Milli-structured bioreactor with immobilized commercial nitrilase for continuous production of nicotinic acid

Maïté Michaud , Carine Vergne-Vaxelaire , Véronique de Berardinis , Anne Zaparucha , Guillaume Nonglaton
EPIC 8 - 8th European Process Intensification Conference, May 2023, Varsovie, Poland
Conference papers cea-04431033v1
Image document

Comparison of the biocatalytic performances of immobilized nitrilase in milli-scale reactors for continuous production of nicotinic acid

Maïté Michaud , Zoe Anxionnaz-Minvielle , Véronique de Berardinis , Guillaume Nonglaton , Anne Zaparucha
BIOTRANS - 16th International Symposium on Biocatalysis & Biotransformations, Jun 2023, La Rochelle, France
Conference papers cea-04431030v1
Image document

Immobilized nitrilase in continuous bioreactors: packed bed reactor vs. milli-structured pillar reactor

Maïté Michaud , Carine Vergne-Vaxelaire , Véronique de Berardinis , Anne Zaparucha , Guillaume Nonglaton
ECCEECAB 2023 - 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology, Sep 2023, Berlin, Germany
Conference papers cea-04431029v1

Expanding the portfolio of enzymes for biocatalysis by extensive biodiversity screening

Carine Vergne-Vaxelaire , Eddy Elisée , Laurine Ducrot , Raphael Meheust , Mark Stam
6e Symposium International de l'AFERP, Jul 2023, Orsay - Paris, France
Conference papers hal-04327790v1

Expanding the portfolio of native Amine Dehydrogenases by extensive biodiversity screening

Carine Vergne-Vaxelaire , Eddy Elisée , Laurine Ducrot , Raphael Meheust , Mark Stam
BioTrans 2023, Jun 2023, La Rochelle, France
Conference papers hal-04327737v1

Metagenomic expansion and active site analysis of the Amine Dehydrogenase family

Elisée Eddy , Laurine Ducrot , Raphaël Méheust , Mark Stam , Pelletier Eric
International Congress on Biocatalysis 2022, Aug 2022, Hamburg, Germany
Conference papers hal-04360123v1

Hybrid catalysis: towards an optimal combination of catalysts Application to HMF valorization

Antoine Lancien , Aurelie Fossey , Robert Wojcieszak , Rénato Froidevaux , Matthias Höhne
ISGC 2022, May 2022, La Rochelle, France
Conference papers hal-04158400v1

CoA ligase for amide and lactam synthesis

Touré Océane , Capra Nikolas , Lelièvre Chloé , Fossey Aurélie , Vergne-Vaxelaire Carine
CBSO, Jun 2022, Visio conférence, France
Conference papers hal-04405375v1

Expanding the portfolio of native Amine Dehydrogenases by extensive biodiversity screening

Carine Vergne-Vaxelaire , Eddy Elisée , Laurine Ducrot , Raphael Meheust , Mark Stam
Amine BioCat 5.0, Nov 2022, Groningen, Netherlands
Conference papers hal-04328280v1

An overview of the native amine dehydrogenase family : discovery, structural and genomic exploration, protein engineering and biocatalytic applications

Carine Vergne-Vaxelaire , Laurine Ducrot , Megan Bennett , Eddy Elisée , Karine Bastard
28e colloque du Club de Biocatalyse en Synthèse Organique, Arkema; Proteus; CBSO, Sep 2021, Lège Cap-Ferret, France
Conference papers hal-04328296v1

Valorisation of bio-based furfurals by hybrid catalysis: towards the synthesis of new amine polymers and surfactants

Antoine Lancien , Aurélie Fossey , Robert Wojcieszak , Rénato Froidevaux , Anne Zaparucha
CBSO2021, Sep 2021, Cap Ferret, France
Conference papers hal-04303442v1

Expanding the substrate scope of Amine Dehydrogenases by protein engineering

Carine Vergne-Vaxelaire , Megan Bennett , Laurine Ducrot , Eddy Elisée , Anne Zaparucha
BioTrans 2021, Jul 2021, Graz (virtual conference), Austria
Conference papers hal-04328324v1

MODAMDH: identification of diverse Amine Dehydrogenases by screening biodiversity using sequence and structure-based approaches

Elisée Eddy , Laurine Ducrot , Raphaël Méheust , Karine Bastard , Aurélie Fossey-Jouenne
29th Conference on Intelligent Systems for Molecular Biology (ISMB) - 20th European Conference on Computational Biology (ECCB), Jul 2021, Virtual conference, United States
Conference papers hal-04359840v1

Hybrid catalysis: towards an optimal combination of catalysts Application to HMF valorization

Antoine Lancien , Aurélie Fossey , Robert Wojcieszak , Rénato Froidevaux , Anne Zaparucha
CBSO2021, Sep 2021, Cap Ferret, France
Conference papers hal-04345706v1

Large scale exploration of the biocatalytic capability of biodiversity for biocatalysis & synthetic biology applications

Véronique de Berardinis , Jean-Louis Petit , Carine Vergne-Vaxelaire , David Vallenet , Anne Zaparucha
First International symposium on High-Throughput Catalysts Design, Jun 2021, Virtual conference (Lille), France
Conference papers hal-04315412v1

MODAMDH: identification of diverse Amine Dehydrogenases by screening biodiversity using innovative in silico approaches

Eddy Elisée , Raphael Meheust , Laurine Ducrot , Mark Stam , Eric Pelletier
International Symposium on High-Throughput Catalyst Design, Jun 2021, Lille (Virtual), France
Conference papers hal-04328578v1

Metagenomic mining for Amine Dehydrogenase discovery

Carine Vergne-Vaxelaire , Adam Caparco , Eric Pelletier , Jean-Louis Petit , Aurélie Fossey-Jouenne
Amine Biocatalysis 4.0, Feb 2020, Stuttgart, Germany
Conference papers hal-04327878v1

Exploring biodiversity for biocatalyst discovery: applications to synthetic chemistry and synthetic biology

Véronique de Berardinis , Anne Zaparucha , David Vallenet , Carine Vergne , Jean-Louis Petit
GMGM Open Scientific day & IPCB Inauguration, May 2019, Strabourg, France
Conference papers hal-04315453v1

A family of Native Amine Dehydrogenases for the Asymmetric Reductive Amination of Ketones

Carine Vergne-Vaxelaire , Ombeline Mayol , Karine Bastard , Lilian Beloti , Amina Frese
Novel Enzymes 2018, Technische Universitat Darmstadt, Oct 2018, Damstadt, Germany
Conference papers hal-04328306v1

Enzymatic cascade synthesis of chiral building-blocks from L-lysine

Anne Zaparucha , Raphael Dubois , Olivier Peruch , Damien Baud , Pierre-Loic Saaidi
Multiple Enzyme Cascade Processes Congress, Mar 2018, Trondheim ( Norvège), Norway
Conference papers hal-04303639v1

Enzymatic cascades for the synthesis of amino alcohols

Anne Zaparucha , Damien Baud , Olivier Peruch , Pierre-Loic Saaidi , Aurélie Fossey
BIOTRANS, Jul 2017, Budapest (Hungary), Hungary
Conference papers hal-04303631v1

Nouvelle dioxygénases alpha-cetoglutarate dépendantes pour la synthèse de plateformes chirales

Anne Zaparucha , Damien Baud , Pierre-Loic Saaidi , Marine Harari , Julien Cuccaro
CBSO, Jun 2014, Carry Le Rouet, France
Conference papers hal-04303652v1

Large nitrilase activity screening on structurally diverse substrates: providing new biocatalytic tools for organic synthesis

Anne Zaparucha , Carine Vergne-Vaxelaire , Franck Bordier , Ekaterina Darii , Aurélie Fossey
BIOTRANS, Jul 2013, Manchester (UK), United Kingdom
Conference papers hal-04303622v1

De la biodiversité à la biocatalyse

Anne Zaparucha
CBSO, Jun 2012, Evry, France
Conference papers hal-04303647v1

Adapting an acyl CoA ligase from Metallosphaera sedula for lactam formation by structure-guided protein engineering

Nikolas Capra , Chloé Lelièvre , Océane Touré , Aurélie Fossey-Jouenne , Carine Vergne-Vaxelaire
Frontiers in Catalysis, 2024, 4, ⟨10.3389/fctls.2024.1360129⟩
Journal articles hal-04489511v1
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Native amine dehydrogenases can catalyze the direct reduction of carbonyl compounds to alcohols in the absence of ammonia

Aurélie Fossey-Jouenne , Laurine Ducrot , Ewald Jongkind , Eddy Elisée , Anne Zaparucha
Frontiers in Catalysis, 2023, 3, pp.1105948. ⟨10.3389/fctls.2023.1105948⟩
Journal articles hal-04178006v1
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Expanding the substrate scope of native amine dehydrogenases through in silico structural exploration and targeted protein engineering

Laurine Ducrot , Megan Bennett , Gwenaëlle André-Leroux , Eddy Elisée , Sacha Marynberg
ChemCatChem, 2022, 2022, pp.e202200880. ⟨10.1002/cctc.202200880⟩
Journal articles cea-03781286v1

Synthesis of Chiral Amines via a Bi‐Enzymatic Cascade Using an Ene‐Reductase and Amine Dehydrogenase

Ewald Jongkind , Aurélie Fossey-Jouenne , Ombeline Mayol , Anne Zaparucha , Carine Vergne-Vaxelaire
ChemCatChem, 2022, 14 (2), ⟨10.1002/cctc.202101576⟩
Journal articles hal-04177991v1

Purification and Characterization of Nitphym, a Robust Thermostable Nitrilase From Paraburkholderia phymatum

Thomas Bessonnet , Aline Mariage , Jean-Louis Petit , Virginie Pellouin , Adrien Debard
Frontiers in Bioengineering and Biotechnology, 2021, 9, ⟨10.3389/fbioe.2021.686362⟩
Journal articles cea-03664095v1

Biocatalytic Reductive Amination by Native Amine Dehydrogenases to Access Short Chiral Alkyl Amines and Amino Alcohols

Laurine Ducrot , Megan Bennett , Adam Caparco , Julie Champion , Andreas Bommarius
Frontiers in Catalysis, 2021, 1, ⟨10.3389/fctls.2021.781284⟩
Journal articles hal-04178002v1

Complete Genome Sequences of Two Pseudomonas Species Isolated from Marine Environments of the Pacific Ocean

Shi-Zhen Wang , Corinne Cruaud , Jean-Marc Aury , David Vallenet , Julie Poulain
Microbiology Resource Announcements, 2021, 10 (16), ⟨10.1128/mra.01062-19⟩
Journal articles hal-04178012v1

Nitrilase immobilization and transposition from a micro‐scale batch to a continuous process increase the nicotinic acid productivity

Chalore Teepakorn , Petra Zajkoska , Gregory Cwicklinski , Véronique de Berardinis , Anne Zaparucha
Biotechnology Journal, 2021, 16 (10), pp.2100010. ⟨10.1002/biot.202100010⟩
Journal articles hal-03664115v1

Metagenomic Mining for Amine Dehydrogenase Discovery

Adam Caparco , Eric Pelletier , Jean Louis Petit , Aurélie Jouenne , Bettina Bommarius
Advanced Synthesis and Catalysis, 2020, 362 (12), pp.2427-2436. ⟨10.1002/adsc.202000094⟩
Journal articles hal-04150129v1
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XszenFHal, a novel tryptophan 5-halogenase from Xenorhabdus szentirmaii

Jérémy Domergue , Diane Erdmann , Aurélie Fossey-Jouenne , Jean-Louis Petit , Adrien Debard
AMB Express, 2019, 9 (1), pp.175. ⟨10.1186/s13568-019-0898-y⟩
Journal articles pasteur-03026562v1

XszenFHal, a novel tryptophan 5-halogenase from Xenorhabdus szentirmaii

Jérémy Domergue , Diane Erdmann , Aurélie Fossey-Jouenne , Jean-Louis Petit , Adrien Debard
AMB Express, 2019, 9 (1), pp.175. ⟨10.1186/s13568-019-0898-y⟩
Journal articles hal-04166372v1
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A family of native amine dehydrogenases for the asymmetric reductive amination of ketones

Ombeline Mayol , Karine Bastard , Lilian Beloti , Amina Frese , Johan P Turkenburg
Nature Catalysis, 2019, 2 (4), pp.324-333. ⟨10.1038/s41929-019-0249-z⟩
Journal articles hal-02945525v1

ATP Regeneration System in Chemoenzymatic Amide Bond Formation with Thermophilic CoA Ligase

Chloé Lelièvre , Mélanie Balandras , Jean‐louis Petit , Carine Vergne-Vaxelaire , Anne Zaparucha
ChemCatChem, 2019, 12 (4), pp.1184-1189. ⟨10.1002/cctc.201901870⟩
Journal articles hal-04167114v1
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Characterization of a thermotolerant ROK-type mannofructokinase from Streptococcus mitis: application to the synthesis of phosphorylated sugars

Carine Vergne-Vaxelaire , Aline Mariage , Jean-Louis Petit , Aurélie Fossey-Jouenne , Christine Guérard-Hélaine
Applied Microbiology and Biotechnology, 2018, 102 (13), pp.5569-5583. ⟨10.1007/s00253-018-9018-1⟩
Journal articles hal-02323767v1
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Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family

Karine Bastard , Tatiana Isabet , Enrico Stura , Pierre Legrand , Anne Zaparucha
Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-34795-9⟩
Journal articles cea-02099557v1

Enzymatic cascade reactions for the synthesis of chiral amino alcohols from L-lysine

Aurélie Fossey-Jouenne , Carine Vergne-Vaxelaire , Anne Zaparucha
Journal of visualized experiments : JoVE, 2018, 132, pp.e56926. ⟨10.3791/56926⟩
Journal articles cea-04311404v1

Biocatalytic Approaches towards the Synthesis of Chiral Amino Alcohols from Lysine: Cascade Reactions Combining alpha-Keto Acid Oxygenase Hydroxylation with Pyridoxal Phosphate- Dependent Decarboxylation

Damien Baud , Olivier Peruch , Pierre-Loïc Saaidi , Aurélie Fossey , Aline Mariage
Advanced Synthesis & Catalysis, 2017, 359 (9), pp.1563-1569. ⟨10.1002/adsc.201600934⟩
Journal articles hal-04167194v1

Parallel evolution of non-homologous isofunctional enzymes in methionine biosynthesis

Karine Bastard , Alain Perret , Aline Mariage , Thomas Bessonnet , Agnès Pinet-Turpault
Nature Chemical Biology, 2017, 13, pp.858-866. ⟨10.1038/nchembio.2397⟩
Journal articles cea-02132779v1

Asymmetric reductive amination by a wild-type amine dehydrogenase from the thermophilic bacteria Petrotoga mobilis

Ombeline Mayol , Sylvain David , Ekaterina Darii , Adrien Debard , Aline Mariage
Catalysis Science & Technology, 2016, 6 (20), pp.7421-7428. ⟨10.1039/C6CY01625A⟩
Journal articles hal-04177990v1

Debromokeramadine from the marine sponge Agelas cf. mauritiana: isolation and short regioselective and flexible synthesis

Cosima Schroif-Grégoire , Jérôme Appenzeller , Cécile Debitus , Anne Zaparucha , Ali Al-Mourabit
Tetrahedron, 2015, 71 (22), pp.3609-3613. ⟨10.1016/j.tet.2014.12.081⟩
Journal articles hal-01152783v1
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Synthesis of Mono- and Dihydroxylated Amino Acids with New $\alpha$-Ketoglutarate-Dependent Dioxygenases: Biocatalytic Oxidation of C$-$H Bonds

Damien Baud , Pierre-Loïc Saaidi , Adam Monfleur , Marine Harari , Julien Cuccaro
ChemCatChem, 2014, 6, pp.3012 - 3017. ⟨10.1002/cctc.201402498⟩
Journal articles cea-01591870v1

Revealing the hidden functional diversity of an enzyme family

Karine Bastard , Adam Alexander Thil Smith , Carine Vergne-Vaxelaire , Alain Perret , Anne Zaparucha
Nature Chemical Biology, 2014, 10 (1), pp.42-49. ⟨10.1038/nchembio.1387⟩
Journal articles hal-02504067v1

Large α-aminonitrilase activity screening of nitrilase superfamily members: Access to conversion and enantiospecificity by LC–MS

Franck Bordier , Mark Stam , Ekaterina Darii , Sabine Tricot , Aurélie Fossey
Journal of Molecular Catalysis B: Enzymatic, 2014, 107, pp.79-88. ⟨10.1016/j.molcatb.2014.05.019⟩
Journal articles hal-02504052v1

Nitrilase Activity Screening on Structurally Diverse Substrates: Providing Biocatalytic Tools for Organic Synthesis

Carine Vergne-Vaxelaire , Franck Bordier , Aurélie Fossey , Marielle Besnard-Gonnet , Adrien Debard
Advanced Synthesis and Catalysis, 2013, 355 (9), pp.1763-1779. ⟨10.1002/adsc.201201098⟩
Journal articles hal-02503873v1

3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation

Marco Bellinzoni , Karine Bastard , Alain Perret , Anne Zaparucha , Nadia Perchat
Journal of Biological Chemistry, 2011, 286 (31), pp.27399-27405. ⟨10.1074/jbc.M111.253260⟩
Journal articles pasteur-03137933v1

N-Pyridinium imidates as new sources of 2-aminoimidazole and imidazoline derivatives

S. Picon , A. Zaparucha , A. Al Mourabit
Tetrahedron Letters, 2009, 50 (49), pp.6826-6829. ⟨10.1016/j.tetlet.2009.09.101⟩
Journal articles hal-00433240v1

Biomimetically inspired short access to the 2-aminoimidazole-fused tetracyclic core of (+/-)-dibromoagelaspongin.

Sylvain Picon , Huu Dau Elise Tran , Marie-Thérèse Martin , Pascal Retailleau , Anne Zaparucha
Organic Letters, 2009, 11 (12), pp.2523-6. ⟨10.1021/ol900745c⟩
Journal articles hal-00432043v1

A Conserved Gene Cluster Rules Anaerobic Oxidative Degradation of L-Ornithine

Nuria Fonknechten , A. Perret , N. Perchat , S. Tricot , C. Lechaplais
Journal of Bacteriology, 2009, 191 (9), pp.3162-3167. ⟨10.1128/JB.01777-08⟩
Journal articles hal-02503069v1

Agelasines J, K, and L from the Solomon Islands Marine Sponge Agelas cf. mauritiana

J. Appenzeller , G. Mihci , M. T. Martin , J. F. Gallard , J. L. Menou
Journal of Natural Products, 2008, 71 (8), pp.1451-1454. ⟨10.1021/np800212g⟩
Journal articles hal-00320681v1

Debromodispacamides B and D: isolation from the marine sponge Agelas mauritiana and stereoselective synthesis using a biomimetic proline route.

Carine Vergne , Jérôme Appenzeller , Céline Ratinaud , Marie-Thérèse Martin , Cécile Debitus
Organic Letters, 2008, 10 (3), pp.493-6. ⟨10.1021/ol702866m⟩
Journal articles hal-00265603v1

Preparation of N-alkyl-N′-carboalkoxy guanidines: unexpected effective trans-alkoxylation transforming the 2,2,2-trichloroethoxycarbonyl into various carbamates

C. Schroif-Grégoire , K. Barale , A. Zaparucha , A. Al-Mourabit
Tetrahedron Letters, 2007, 48 (13), pp.2357-2359. ⟨10.1016/j.tetlet.2007.01.126⟩
Journal articles hal-00157575v1

Direct Access to Marine Pyrrole-2-aminoimidazoles, Oroidin, and Derivatives, via New Acyl-1,2-dihydropyridin Intermediates

C. Schroif-Grégoire , N. Travert , A. Zaparucha , A. Al-Mourabit
Organic Letters, 2006, 8(14), pp.2961-2964. ⟨10.1021/ol0608451⟩
Journal articles hal-00089125v1

Synthesis of metal complexes of 2,9-bis(2-hydroxyphenyl)-1,10-phenanthroline and their DNA binding and cleaving activities

Sylvain Routier , Valérie Joanny , Anne Zaparucha , Herve Vezin , Jean-Pierre Catteau
Journal of the Chemical Society, Perkin Transactions 2, 1998, Journal of the Chemical Society, Perkin Transactions 2, pp.863-868. ⟨10.1039/a707941i⟩
Journal articles hal-03423348v1

Metagenomic expansion and active site analysis of the Amine Dehydrogenase family

Elisée Eddy , Laurine Ducrot , Raphaël Méheust , Mark Stam , Pelletier Eric
International Congress on Biocatalysis 2022, Aug 2022, Hamburg, Germany
Conference poster hal-04360138v1

MODAMDH: identification of diverse Amine Dehydrogenases by screening biodiversity using sequence and structure-based approaches

Elisée Eddy , Laurine Ducrot , Raphaël Méheust , Karine Bastard , Aurélie Fossey-Jouenne
29th Conference on Intelligent Systems for Molecular Biology (ISMB) - 20th European Conference on Computational Biology (ECCB), Jul 2021, Virtual conference, United States
Conference poster hal-04359878v1

MODAMDH: identification of diverse Amine Dehydrogenases by screening biodiversity using sequence and structure-based approaches

Elisée Eddy , Laurine Ducrot , Raphaël Méheust , Karine Bastard , Aurélie Fossey-Jouenne
BioTrans 2021, Jul 2021, Graz (Virtual Conference), Austria
Conference poster hal-04360034v1

One-pot bi-enzymatic cascade with an Old Yellow Enzyme and a native amine dehydrogenase to synthesize chiral amines

Ewald Jongkind , Aurélie Fossey-Jouenne , Ombeline Mayol , Anne Zaparucha , Carine Vergne-Vaxelaire
BioTrans 2021, Jul 2021, Graz (virtual conference), Austria
Conference poster hal-04328842v1

CoA ligase for lactam synthesis

Touré Océane , Capra Nikolas , Lelièvre Chloé , Vergne-Vaxelaire Carine , Thunnissen Andy-Mark
CBSO, Sep 2021, Cap Ferret, France
Conference poster hal-04405342v1

Production of valuable hydroxylated-L-lysine by novel α-keto acid dependent oxygenases

Selina Seide , Anne Zaparucha , Katrin Rosenthal , Stephan Lütz , Martina Pohl
BIOTRANS, Jul 2019, Groningen, Netherlands
Conference poster hal-04405143v1

From structural elucidation to active site classification: exploration of an enzyme family

Karine Bastard , Tatiana Isabet , Enrico A Stura , Pierre Legrand , Anne Zaparucha
BIOTRANS, Jul 2019, Groningen, Netherlands
Conference poster hal-04405103v1

Smart ATP regeneration system for chemoenzymatic amide bond formation

Chloé M. Lelièvre , Mélanie Balandras , Adrien Debard , Virginie Pellouin , Jean-Louis Petit
14th Biotrans symposium, Jul 2019, Groningen, Netherlands
Conference poster hal-04354478v1