Arnaud Billet

Maître de conférences BTSB EA7417 INU Champollion

Documents

Publications

	Isolation, NMR Characterization, and Bioactivity of a Flavonoid Triglycoside from Anthyllis henoniana Stems: Antioxidant and Antiproliferative Effects on MDA-MB-231 Breast Cancer Cells Amani Ayachi , Guillaume Boy , Sonda Samet , Nathan Téné , Bouthaina Bouzayani Antioxidants , 2024, 13 (7), pp.793. ⟨10.3390/antiox13070793⟩ Journal articles hal-04635159v1
	Discovery of an Insect Neuroactive Helix Ring Peptide from Ant Venom Valentine Barassé , Laurence Jouvensal , Guillaume Boy , Arnaud Billet , Steven Ascoët Toxins, 2023, 15 (10), pp.600. ⟨10.3390/toxins15100600⟩ Journal articles hal-04390519v1
	The mechanism underlying toxicity of a venom peptide against insects reveals how ants are master at disrupting membranes Steven Ascoët , Axel Touchard , Nathan Téné , Benjamin Lefranc , Jérôme Leprince iScience, 2023, 26 (3), pp.106157. ⟨10.1016/j.isci.2023.106157⟩ Journal articles hal-04071274v1
	The rescue of F508del-CFTR by elexacaftor/tezacaftor/ivacaftor (Trikafta) in human airway epithelial cells is underestimated due to the presence of ivacaftor Frédéric Becq , Sandra Mirval , Thomas Carrez , Manuella Leveque , Arnaud Billet European Respiratory Journal, 2022, 59 (2), pp.2100671. ⟨10.1183/13993003.00671-2021⟩ Journal articles hal-04541610v1
	The multi-faceted nature of 15 CFTR exonic variations: Impact on their functional classification and perspectives for therapy Anne Bergougnoux , A. Billet , C. Ka , M. Heller , F. Degrugillier Journal of Cystic Fibrosis, 2022, ⟨10.1016/j.jcf.2022.12.003⟩ Journal articles hal-03913493v1
	Functional and Pharmacological Characterization of the Rare CFTR Mutation W361R Arnaud Billet , Ahmad Elbahnsi , Mathilde Jollivet-Souchet , Brice Hoffmann , Jean-Paul Mornon Frontiers in Pharmacology, 2020, 11, ⟨10.3389/fphar.2020.00295⟩ Journal articles hal-02557014v1
	Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity Lionel Froux , Ahmad Elbahnsi , Benjamin Boucherle , Arnaud Billet , Nesrine Baatallah European Journal of Medicinal Chemistry, 2020, 190, pp.112116. ⟨10.1016/j.ejmech.2020.112116⟩ Journal articles hal-02924784v1
	Pendrin mediates bicarbonate secretion and enhances CFTR function in airway surface epithelia Dusik Kim , Junwei Huang , Arnaud Billet , Asmahan Abu-Arish , Julie Goepp American Journal of Respiratory Cell and Molecular Biology, 2019, 60 (6), pp.705-716. ⟨10.1165/rcmb.2018-0158OC⟩ Journal articles hal-03145546v1
	Modulating the cystic fibrosis transmembrane regulator and the development of new precision drugs Lionel Froux , Arnaud Billet , Frédéric Becq Expert Review of Precision Medicine and Drug Development, 2018, 3 (6), pp.357-370. ⟨10.1080/23808993.2018.1547109⟩ Journal articles hal-03192898v1
	Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function Arnaud Billet , Lionel Froux , John Hanrahan , Frederic Becq Frontiers in Pharmacology, 2017, 8, pp.195. ⟨10.3389/fphar.2017.00195⟩ Journal articles hal-03191777v1
	Low free drug concentration prevents inhibition of F508del CFTR functional expression by the potentiator VX-770 (ivacaftor) Elizabeth Matthes , Julie Goepp , Graeme Carlile , Yishan Luo , Kurt Dejgaard British Journal of Pharmacology, 2016, 173 (3), pp.459-470. ⟨10.1111/bph.13365⟩ Journal articles hal-03193045v1
	Potential sites of CFTR activation by tyrosine kinases Arnaud Billet , Yanlin Jia , Timothy Jensen , Yue-Xian Hou , Xiu-Bao Chang Channels, 2016, 10 (3), pp.247-251. ⟨10.1080/19336950.2015.1126010⟩ Journal articles hal-03192938v1
	The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epithelia Mark Turner , Elizabeth Matthes , Arnaud Billet , Amy Ferguson , David Thomas American Journal of Physiology - Lung Cellular and Molecular Physiology, 2016, 310 (1), pp.L59-L70. ⟨10.1152/ajplung.00324.2015⟩ Journal articles hal-03193027v1
	Regulation of the cystic fibrosis transmembrane conductance regulator anion channel by tyrosine phosphorylation Arnaud Billet , John W Hanrahan FASEB Journal, 2015, 29 (9), pp.3945-3953. ⟨10.1096/fj.15-273151⟩ Journal articles hal-03192145v1
	The secret life of CFTR as a calcium-activated chloride channel Arnaud Billet , John W Hanrahan The Journal of Physiology, 2013, 591 (21), pp.5273-5278. ⟨10.1113/jphysiol.2013.261909⟩ Journal articles hal-03192129v1
	CFTR: Effect of ICL2 and ICL4 amino acids in close spatial proximity on the current properties of the channel Arnaud Billet , Jean-Paul Mornon , Mathilde Jollivet , Pierre Lehn , Isabelle Callebaut Journal of Cystic Fibrosis, 2013, 12, pp.737-745. ⟨10.1016/j.jcf.2013.02.002⟩ Journal articles hal-00907930v1
	Role of Tyrosine Phosphorylation in the Muscarinic Activation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Arnaud Billet , Yishan Luo , Haouaria Balghi , John Hanrahan Journal of Biological Chemistry, inPress, 288 (30), pp.21815-21823. ⟨10.1074/jbc.M113.479360⟩ Journal articles hal-03191691v1
	Stimulation of wild-type, F508del- and G551D-CFTR chloride channels by non-toxic modified pyrrolo[2,3-b]pyrazine derivatives Luc Dannhoffer , Arnaud Billet , Mathilde Jollivet-Souchet , Patricia Melin-Heschel , Christelle Faveau Frontiers in Pharmacology, 2011, 2, ⟨10.3389/fphar.2011.00048⟩ Journal articles hal-03192023v1
	C terminus of nucleotide binding domain 1 contains critical features for cystic fibrosis transmembrane conductance regulator trafficking and activation. Arnaud Billet , Patricia Melin , Mathilde Jollivet , Jean-Paul Mornon , Isabelle Callebaut Journal of Biological Chemistry, 2010, 285 (29), pp.22132-40. ⟨10.1074/jbc.M110.120683⟩ Journal articles hal-00582442v1
	Understanding nucleotide binding and CFTR ion channel gating: how many cycles? Frédéric Becq , Arnaud Billet Expert Review of Respiratory Medicine, 2010, 4 (4), pp.451-4. ⟨10.1586/ers.10.47⟩ Journal articles hal-00561612v1
	Identification of a novel water-soluble activator of wild-type and F508del CFTR: GPact-11a. J. Bertrand , B. Boucherle , A. Billet , P. Melin-Heschel , L. Dannhoffer European Respiratory Journal, 2010, 36 (2), pp.311-22. ⟨10.1183/09031936.00122509⟩ Journal articles hal-00559199v1

	Comparative investigation of the mechanisms of two cytotoxic venom peptides from the ant Tetramorium bicarinatum. Steven Ascoët , Nathan Téné , Axel Touchard , Jérôme Leprince , Françoise Paquet e-RT27 – 27th Meeting of the French Society of Toxinology, Dec 2021, virtual, France Conference poster hal-03519944v1
	Analogous peptides acting on different pathways: a comparative study of Bicarinalin and U9-MYRTX-Tb1a from an ant venom Steven Ascoët , Nathan Téné , Axel Touchard , Valentine Barassé , Jérôme Leprince 1st International Electronic Conference on Toxins, Jan 2021, Basel (online), Switzerland. , 2021 Conference poster hal-03191770v1

	Adaptive trade-offs between vertebrate defense and insect predation drive ant venom evolution Axel Touchard , Samuel D Robinson , Hadrien Lalagüe , Steven Ascoët , Arnaud Billet 2024 Preprints, Working Papers, ... hal-04664882v1

Arnaud Billet

Publications

Isolation, NMR Characterization, and Bioactivity of a Flavonoid Triglycoside from Anthyllis henoniana Stems: Antioxidant and Antiproliferative Effects on MDA-MB-231 Breast Cancer Cells

Discovery of an Insect Neuroactive Helix Ring Peptide from Ant Venom

The mechanism underlying toxicity of a venom peptide against insects reveals how ants are master at disrupting membranes

The rescue of F508del-CFTR by elexacaftor/tezacaftor/ivacaftor (Trikafta) in human airway epithelial cells is underestimated due to the presence of ivacaftor

The multi-faceted nature of 15 CFTR exonic variations: Impact on their functional classification and perspectives for therapy

Functional and Pharmacological Characterization of the Rare CFTR Mutation W361R

Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity

Pendrin mediates bicarbonate secretion and enhances CFTR function in airway surface epithelia

Modulating the cystic fibrosis transmembrane regulator and the development of new precision drugs

Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function

Low free drug concentration prevents inhibition of F508del CFTR functional expression by the potentiator VX-770 (ivacaftor)

Potential sites of CFTR activation by tyrosine kinases

The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epithelia

Regulation of the cystic fibrosis transmembrane conductance regulator anion channel by tyrosine phosphorylation

The secret life of CFTR as a calcium-activated chloride channel

CFTR: Effect of ICL2 and ICL4 amino acids in close spatial proximity on the current properties of the channel

Role of Tyrosine Phosphorylation in the Muscarinic Activation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

Stimulation of wild-type, F508del- and G551D-CFTR chloride channels by non-toxic modified pyrrolo[2,3-b]pyrazine derivatives

C terminus of nucleotide binding domain 1 contains critical features for cystic fibrosis transmembrane conductance regulator trafficking and activation.

Understanding nucleotide binding and CFTR ion channel gating: how many cycles?

Identification of a novel water-soluble activator of wild-type and F508del CFTR: GPact-11a.

Comparative investigation of the mechanisms of two cytotoxic venom peptides from the ant Tetramorium bicarinatum.

Analogous peptides acting on different pathways: a comparative study of Bicarinalin and U9-MYRTX-Tb1a from an ant venom

Adaptive trade-offs between vertebrate defense and insect predation drive ant venom evolution