Arnaud Monteil

31
Documents

Présentation

Arnaud Monteil obtained his bachelor’s in biological sciences in 1989 in Montpellier (France). He then studied molecular biology and biochemistry at the University of Montpellier from 1989 to 1996. He started his PhD in 1996 under the supervision of Dr Joël Nargeot (University of Montpellier – Montpellier – France) with the objective to clone and characterize T-type voltage-gated calcium channels, a subtype of calcium channels that was not identified at this time. The thesis was successfully defended in 2000 and led to several publications of importance in the fields of ion channels and cellular excitability. After his thesis defense, Arnaud Monteil joined Prof Richard J. Miller’s laboratory as a post-doctoral fellow at the University of Chicago (Chicago – USA) where he identified and cloned a novel type of four-domain ion channel named NALCN. He went back to France in 2001 as a permanent researcher at the National Center for Scientific Research (CNRS). Since then Arnaud Monteil’s research is concerned with ion channels in Dr Philippe Lory’s team (« *Ion channels in neuronal excitability and diseases » - Institut de Génomique Fonctionnelle – Montpellier ; http://www.igf.cnrs.fr). Dr Philippe Lory’s team is part of the Laboratory of Excellence « Ion Channel Science and Therapeutics » (http://www.labex-icst.fr/en). The overall ambition ofthis laboratory of excellence is to become a world-wide recognized cluster in ion channel studies carrying research and innovation at the interface between biology and medicine. In this context, the research projects headed by Arnaud Monteil focus on the study of ion channels’ mutations involved in complex neurological disorders using molecular and electrophysiological techniques both in vitro (cell lines ; primary cultures) and in vivo (animal models). A special emphasis is to search for new molecules modulating ion channels activity that could be relevant to treat human diseases. Of note, Arnaud Monteil supervised 2-year exchange programs (Hubert-Curien Program 2013-2014 and 2020-2021) with Dr Narawut Pakaprot at Mahidol University (Thailand). In addition to his research activity, Arnaud Monteil is the head of a facility to produce viral vectors for research since 2008 (http://www.biocampus.cnrs.fr), is the president of the « Ion Channel » society since 2014 (http://www.canaux-ioniques.fr/) and leads the scientific committee of the Libellas foundation since 2020 (https://fundacionlibellas.org/). Arnaud Monteil is also an elected member of the National Committee of the CNRS (CoNRS, Sub-committee #24 “Aging, Tumorigenesis, Physiology”) since 2016.

Publications

Publications

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The background sodium leak channel NALCN is a major controlling factor in pituitary cell excitability

Marziyeh Belal , Mariusz Mucha , Arnaud Monteil , Paul G Winyard , Robert Pawlak et al.
The Journal of Physiology, 2025, 603 (2), pp.301-317. ⟨10.1113/JP284036⟩
Article dans une revue hal-04819360 v1
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New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN

Arnaud Monteil , Nathalie C. Guérineau , Antonio Gil-Nagel , Paloma Parra- Diaz , Philippe Lory et al.
Physiological Reviews, In press, 104 (1), pp.399-472. ⟨10.1152/physrev.00014.2022⟩
Article dans une revue (article de synthèse) hal-04189096 v1
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The Cognitive Restoration Effects of Resveratrol: Insight Molecular through Behavioral Studies in Various Cognitive Impairment Models

Yingrak Boondam , Chaianan Saefoong , Natjanan Niltup , Arnaud Monteil , Worawan Kitphati
ACS Pharmacology & Translational Science, 2024, 7 (11), pp.3334 - 3357. ⟨10.1021/acsptsci.4c00373⟩
Article dans une revue hal-04787206 v1
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Selective blockade of Ca$_V$1.2 (α1C) versus Ca$_V$1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine

Pietro Mesirca , Jean Chemin , Christian Barrère , Eleonora Torre , Laura Gallot et al.
Nature Communications, 2024, 15 (1), pp.54. ⟨10.1038/s41467-023-43502-w⟩
Article dans une revue hal-04385916 v1
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Revealing of stomach histology of beta-agonist free, hygienic, and natural swine

Saimai Chatree , Nitinart Kongkhwet , Sanfan Inkho , Suthita Jaisamuta , Arnaud Monteil et al.
Cogent Food & Agriculture, 2023, 9 (1), pp.2208248. ⟨10.1080/23311932.2023.2208248⟩
Article dans une revue hal-04710696 v1
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NALCN ‐mediated sodium influx confers metastatic prostate cancer cell invasiveness

Antoine Folcher , Dmitri Gordienko , Oksana Iamshanova , Alexandre Bokhobza , George Shapovalov et al.
EMBO Journal, In press, 42 (13), pp.e112198. ⟨10.15252/embj.2022112198⟩
Article dans une revue hal-04122134 v1
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Functional mapping of microRNA promoters with dCas9 fused to transcriptional regulators

Pradeep Kumar , Mathilde Courtes , Céline Lemmers , Anne Le Digarcher , Ilda Coku et al.
Frontiers in Genetics, 2023, 14, pp.1147222. ⟨10.3389/fgene.2023.1147222⟩
Article dans une revue hal-04122098 v1
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Emerging and re-emerging zoonotic viral diseases in Southeast Asia: One Health challenge

Paola Mariela Saba Villarroel , Nuttamonpat Gumpangseth , Thanaphon Songhong , Sakda Yainoy , Arnaud Monteil et al.
Frontiers in Public Health, 2023, 11, ⟨10.3389/fpubh.2023.1141483⟩
Article dans une revue hal-04234422 v1
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Effects of Ceftriaxone on Oxidative Stress and Inflammation in a Rat Model of Chronic Cerebral Hypoperfusion

Apsorn Sattayakhom , Kosin Kalarat , Thatdao Rakmak , Sompol Tapechum , Arnaud Monteil et al.
Behavioral Sciences, 2022, 12 (8), pp.287. ⟨10.3390/bs12080287⟩
Article dans une revue hal-03761404 v1
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Sodium background currents in endocrine/neuroendocrine cells: towards unraveling channel identity and contribution in hormone secretion

Nathalie C. Guérineau , Arnaud Monteil , Philippe Lory
Frontiers in Neuroendocrinology, 2021, 63, pp.100947. ⟨10.1016/j.yfrne.2021.100947⟩
Article dans une revue (article de synthèse) hal-03364483 v1
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A sodium background conductance controls the spiking pattern of mouse adrenal chromaffin cells in situ

Alexandre Milman , Stephanie Venteo , Jean‐louis Bossu , Pierre Fontanaud , Arnaud Monteil et al.
The Journal of Physiology, 2021, 599 (6), pp.1855-1883. ⟨10.1113/jp281044⟩
Article dans une revue hal-03138604 v1
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THE VOLTAGE-GATED SODIUM CHANNEL BETA4 SUBUNIT MAINTAINS EPITHELIAL PHENOTYPE IN MAMMARY CELLS

Adélaïde Doray , Roxane Lemoine , Marc Severin , Stéphanie Chadet , Osbaldo Lopez-Charcas et al.
Cells, 2021, 10 (7), pp.1624. ⟨10.3390/cells10071624⟩
Article dans une revue hal-03353576 v1
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The sodium leak channel NALCN regulates cell excitability of pituitary endocrine cells

Hathaichanok Impheng , Céline Lemmers , Malik Bouasse , Christian Legros , Narawut Pakaprot et al.
FASEB Journal, 2021, 35 (5), pp.e21400. ⟨10.1096/fj.202000841rr⟩
Article dans une revue hal-03188856 v1
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Neuronal Cav3 channelopathies: recent progress and perspectives

Philippe Lory , Sophie Nicole , Arnaud Monteil
Pflügers Archiv European Journal of Physiology, 2020, 472 (7), pp.831-844. ⟨10.1007/s00424-020-02429-7⟩
Article dans une revue (article de synthèse) hal-02893632 v1
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Cav3.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons

Miriam Candelas , Ana Reynders , Margarita Arango-Lievano , Christoph Neumayer , Antoine Fruquière et al.
Scientific Reports, 2019, 9 (1), pp.3112. ⟨10.1038/s41598-019-39703-3⟩
Article dans une revue hal-02356250 v1
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Interferon-inducible protein (IFI) 16 regulates Chikungunya and Zika virus infection in human skin fibroblasts.

Sineewanlaya Wichit , Rodolphe Hamel , Sakda Yainoy , Nuttamonpat Gumpangseth , Suchawadee Panich et al.
EXCLI Journal, 2019, 18, pp.467-476. ⟨10.17179/excli2019-1271⟩
Article dans une revue hal-02328306 v1
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Functional expression of CLIFAHDD and IHPRF pathogenic variants of the NALCN channel in neuronal cells reveals both gain- and loss-of-function properties

Malik Bouasse , Hathaichanok Impheng , Zoe Servant , Philippe Lory , Arnaud Monteil
Scientific Reports, 2019, 9 (1), pp.11791. ⟨10.1038/s41598-019-48071-x⟩
Article dans une revue hal-02328271 v1
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Calmodulin regulates Ca v 3 T-type channels at their gating brake

Jean Chemin , Valentina Taiakina , Arnaud Monteil , Michael Piazza , Wendy Guan et al.
Journal of Biological Chemistry, 2017, 292 (49), pp.20010-20031. ⟨10.1074/jbc.M117.807925⟩
Article dans une revue hal-02328290 v1

De novo mutations in NALCN cause a syndrome characterized by congenital contractures of the limbs and face, hypotonia, and developmental delay

J. X. Chong , M. J. Mcmillin , K. M. Shively , A. E. Beck , C. T. Marvin et al.
American Journal of Human Genetics, 2015, 96 (3), pp.462-73. ⟨10.1016/j.ajhg.2015.01.003⟩
Article dans une revue hal-02064371 v1
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Inhibition of Cav3.2 T-type Calcium Channels by Its Intracellular I-II Loop

Arnaud Monteil , Patrick Chausson , Katia Boutourlinsky , Alexandre Mezghrani , Iulia Blesneac et al.
Journal of Biological Chemistry, 2015, 290 (26), pp.16168-16176. ⟨10.1074/jbc.M114.634261⟩
Article dans une revue hal-01348945 v1
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A Recurrent Mutation in CACNA1G Alters Cav3.1 T-Type Calcium-Channel Conduction and Causes Autosomal-Dominant Cerebellar Ataxia

Marie Coutelier , Iulia Blesneac , Arnaud Monteil , Marie-Lorraine Monin , Kunie Ando et al.
American Journal of Human Genetics, 2015, 97 (5), pp.726-737. ⟨10.1016/j.ajhg.2015.09.007⟩
Article dans une revue hal-01223815 v1
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The sodium leak channel, NALCN, in health and disease

Maud Cochet-Bissuel , Philippe Lory , Arnaud Monteil
Frontiers in Cellular Neuroscience, 2014, 8, pp.132. ⟨10.3389/fncel.2014.00132⟩
Article dans une revue hal-01950130 v1
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Gd3+ and calcium sensitive, sodium leak currents are features of weak membrane-glass seals in patch clamp recordings

Adrienne N. Boone , Adriano Senatore , Jean Chemin , Arnaud Monteil , J. David Spafford
PLoS ONE, 2014, 9 (6), pp.e98808. ⟨10.1371/journal.pone.0098808⟩
Article dans une revue hal-01943334 v1
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A Ca(v)3.2/syntaxin-1A signaling complex controls T-type channel activity and low-threshold exocytosis.

Norbert Weiss , Shahid Hameed , José M. Fernández-Fernández , Katell Fablet , Maria Karmazinova et al.
Journal of Biological Chemistry, 2012, 287 (4), pp.2810-8. ⟨10.1074/jbc.M111.290882⟩
Article dans une revue inserm-00757396 v1
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The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic β‐cell line

Leigh Anne Swayne , Alexandre Mezghrani , Annie Varrault , Jean Chemin , Gyslaine Bertrand et al.
EMBO Reports, 2009, 10 (8), pp.873 - 880. ⟨10.1038/embor.2009.125⟩
Article dans une revue hal-03760963 v1

Regulation of T-type calcium channels: Signalling pathways and functional implications

Sylvaine Huc-Brandt , Arnaud Monteil , Isabelle Bidaud , Guillaume Barbara , Jean Chemin et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 2009, 1793 (6), pp.947-952. ⟨10.1016/j.bbamcr.2008.11.003⟩
Article dans une revue hal-02282056 v1

The multifunctional protein GC1q-R interacts specifically with the i3 loop arginine cluster of the vasopressin V-2 receptor

Sebastien Granier , Frederic Jean-Alphonse , Daniel Bacqueville , Arnaud Monteil , Robert Pascal et al.
Regulatory Peptides, 2008, 148, pp.76-87. ⟨10.1016/j.regpep.2008.01.007⟩
Article dans une revue istex hal-00493436 v1

Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception

Emmanuel Bourinet , A. Alloui , Arnaud Monteil , Christian Barrère , Brigitte Couette et al.
EMBO Journal, 2005, 24, pp.315-324. ⟨10.1038/sj.emboj.7600515⟩
Article dans une revue hal-00016908 v1

α 1H mRNA in single skeletal muscle fibres accounts for T‐type calcium current transient expression during fetal development in mice

Christine Berthier , Arnaud Monteil , Philippe Lory , Caroline Strube
The Journal of Physiology, 2002, 539 (3), pp.681-691. ⟨10.1113/jphysiol.2001.013246⟩
Article dans une revue hal-03093134 v1

Deciphering pathogenic mechanisms underlying human calcium channelopathies

Philippe Lory , Jean Chemin , Arnaud Monteil , Nathalie C. Guérineau , Sophie Nicole et al.
3rd Congress of Physiology and Integrative Biology (CPBI) and 86th Congress of French Physiological Society (SFP), Société Française de Physiologie, Jun 2019, Montpellier, France
Communication dans un congrès hal-03020963 v1