Benoit BUSSER

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Publications

Potent Biological Activity by a Synthetic Cu(I) Cationophore Redistributing Intracellular Copper Pools

Nathan Renier , Gianluca Weyckmans Mele , Pierre Lelievre , Mélanie Boeckstaens , Roy Lavendomme et al.

Journal of the American Chemical Society, 2026, 148 (1), pp.593-604. ⟨10.1021/jacs.5c15335⟩

Article dans une revue hal-05513296v1

In vivo vectorization and delivery systems for gene therapies and RNA-based therapeutics in oncology

Julie Schock Vaiani , Mans Broekgaarden , Jean-Luc Coll , Lucie Sancey , Benoit Busser

Nanoscale, 2025, 17 (10), pp.5501-5525. ⟨10.1039/d4nr05371k⟩

Article dans une revue inserm-04945753v1

Soluble VE-cadherin as a biomarker of response to immunotherapy by anti-PD1 in metastatic melanoma

Clémentine Broche , Khémary Um , Isabelle Vilgrain , Stéphane Mouret , Marie-Thérèse Leccia et al.

British Journal of Cancer, 2025, 132 (10), pp.863-865. ⟨10.1038/s41416-025-03026-0⟩

Article dans une revue hal-05280347v1
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Quantifying Titanium Exposure in Lung Tissues: A Novel Laser‐Induced Breakdown Spectroscopy Elemental Imaging‐Based Analytical Framework for Biomedical Applications

Vincent Gardette , Lucie Sancey , Marine Leprince , Laurent Gaté , Frederic Cosnier et al.

Small Science, 2024, ⟨10.1002/smsc.202300307⟩

Article dans une revue hal-04510056v1

Enhancing Diagnostic Capabilities for Occupational Lung Diseases Using LIBS Imaging on Biopsy Tissue

Victor H.C. Ferreira , Vincent Gardette , Benoit Busser , Lucie Sancey , Steven Ronsmans et al.

Analytical Chemistry, 2024, ⟨10.1021/acs.analchem.4c00237⟩

Article dans une revue hal-04552785v1
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WazaGaY: An Innovative Aza-BODIPY-Derived Near-Infrared Fluorescent Probe for Enhanced Tumor Imaging

Mohamed Bendellaa , Charlotte Cave , Amélie Godard , Fabien Dalonneau , Annika Sickinger et al.

Journal of Medicinal Chemistry, 2024, 67 (18), pp.16635-16648. ⟨10.1021/acs.jmedchem.4c01435⟩

Article dans une revue hal-04739530v1
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Engineering Radiocatalytic Nanoliposomes with Hydrophobic Gold Nanoclusters for Radiotherapy Enhancement

Nazareth Milagros Carigga Gutierrez , Tristan Le Clainche , Anne‐laure Bulin , Sofia Leo , Malika Kadri et al.

Advanced Materials, 2024, 36 (50), pp.e2404605. ⟨10.1002/adma.202404605⟩

Article dans une revue inserm-04788875v1
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Comparison of the In Vitro and In Vivo Behavior of a Series of NIR-II-Emitting Aza-BODIPYs Containing Different Water-Solubilizing Groups and Their Trastuzumab Antibody Conjugates

Elisa Chazeau , Christol Fabre , Malorie Privat , Amélie Godard , Cindy Racoeur et al.

Journal of Medicinal Chemistry, 2024, 67 (5), pp.3679-3691. ⟨10.1021/acs.jmedchem.3c02139⟩

Article dans une revue hal-04757976v1
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Roles of zinc in cancers: From altered metabolism to therapeutic applications

Mohamed Bendellaa , Pierre Lelièvre , Jean-Luc Coll , Lucie Sancey , Aurélien Deniaud et al.

International Journal of Cancer, 2024, 154 (1), pp.7-20. ⟨10.1002/ijc.34679⟩

Article dans une revue hal-04205230v1
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Al(III) and Ga(III) Bisphenolate Azadipyrromethene-Based "N(2)O(2)" Complexes as Efficient NIR-Fluorophores

Amélie Godard , Laura Abad Galán , Jean Rouillon , Shaymaa Al Shehimy , Wassima Tajani et al.

Inorganic Chemistry, 2023, 62 (13), pp.5067-5080. ⟨10.1021/acs.inorgchem.2c03918⟩

Article dans une revue hal-03927565v1
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NIR-II Aza-BODIPY Dyes Bioconjugated to Monoclonal Antibody Trastuzumab for Selective Imaging of HER2-Positive Ovarian Cancer

Amélie Godard , Ghadir Kalot , Malorie Privat , Mohamed Bendellaa , Benoit Busser et al.

Journal of Medicinal Chemistry, 2023, 66 (7), pp.5185-5195. ⟨10.1021/acs.jmedchem.3c00100⟩

Article dans une revue hal-04091996v1
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Laser-induced breakdown spectroscopy imaging for material and biomedical applications: recent advances and future perspectives

Vincent Gardette , Vincent Motto-Ros , César Alvarez Llamas , Lucie Sancey , Ludovic Duponchel et al.

Analytical Chemistry, 2023, 95 (1), pp.49-69. ⟨10.1021/acs.analchem.2c04910⟩

Article dans une revue inserm-03933204v1
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Succinimido–Ferrocidiphenol Complexed with Cyclodextrins Inhibits Glioblastoma Tumor Growth In Vitro and In Vivo without Noticeable Adverse Toxicity

Feten Najlaoui , Benoît Busser , Germain Sotoing Taïwe , Pascal Pigeon , Nathalie Sturm et al.

Molecules, 2022, 27 (14), pp.4651. ⟨10.3390/molecules27144651⟩

Article dans une revue hal-03736856v1
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Visualizing the cerebral distribution of chemical elements: a challenge met with LIBS elemental imaging

Benoit Busser , Anne-Laure Bulin , Vincent Gardette , Hélène Elleaume , Frédéric Pelascini et al.

Journal of Neuroscience Methods, 2022, pp.109676. ⟨10.1016/j.jneumeth.2022.109676⟩

Article dans une revue hal-03726566v1
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Lipoprotein interactions with water-soluble NIR-II emitting aza-BODIPYs boost the fluorescence signal and favor selective tumor targeting

Ghadir Kalot , Amélie Godard , Benoit Busser , Mohamed Bendellaa , Fabien Dalonneau et al.

Biomaterials Science, 2022, 10 (21), pp.6315-6325. ⟨10.1039/d2bm01271e⟩

Article dans une revue hal-04253882v1
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Near-infrared emitting fluorescent homobimetallic gold(I) complexes displaying promising in vitro and in vivo therapeutic properties

Robin Lescure , Malorie Privat , Jacques Pliquett , Aurélie Massot , Océane Baffroy et al.

European Journal of Medicinal Chemistry, 2021, 220 (4), pp.113483. ⟨10.1016/j.ejmech.2021.113483⟩

Article dans une revue hal-03436249v1
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IMAGERIE LIBS : AUX PORTES DE LA CLINIQUE

Vincent Motto-Ros , Marine Leprince , Ludovic Duponchel , Lucie Sancey , Vincent Bonneterre et al.

Photoniques, 2020, 103, pp.34-37. ⟨10.1051/photon/202010334⟩

Article dans une revue inserm-02941470v1
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Radiation Dose-Enhancement Is a Potent Radiotherapeutic Effect of Rare-Earth Composite Nanoscintillators in Preclinical Models of Glioblastoma

Anne-Laure Bulin , Mans Broekgaarden , Fréderic Chaput , Victor Baisamy , Jan Garrevoet et al.

Advanced Science, 2020, 7 (20), pp.2001675. ⟨10.1002/advs.202001675⟩

Article dans une revue hal-02939291v1
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Iron Dysregulation in Human Cancer: Altered Metabolism, Biomarkers for Diagnosis, Prognosis, Monitoring and Rationale for Therapy

Pierre Lelièvre , Lucie Sancey , Jean-Luc Coll , Aurélien Deniaud , Benoit Busser

Cancers, 2020, 12 (12), pp.3524. ⟨10.3390/cancers12123524⟩

Article dans une revue hal-03113973v1
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Stapled peptide targeting the CDK4/Cyclin D interface combined with Abemaciclib inhibits KRAS mutant lung cancer growth

Céline Bouclier , Matthieu Simon , Guillaume Laconde , Morgan Pellerano , Sebastien Diot et al.

Theranostics, 2020, 10 (5), pp.2008-2028. ⟨10.7150/thno.40971⟩

Article dans une revue inserm-02440284v1
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Water-Soluble Aza-BODIPYs: Biocompatible Organic Dyes for High Contrast In Vivo NIR-II Imaging

Amélie Godard , Ghadir Kalot , Jacques Pliquett , Benoit Busser , Xavier Le Guével et al.

Bioconjugate Chemistry, 2020, 31 (4), pp.1088-1092. ⟨10.1021/acs.bioconjchem.0c00175⟩

Article dans une revue inserm-02941480v1
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LIBS-Based Imaging: Recent Advances and Future Directions

Vincent Motto-Ros , V Gardette , L Sancey , M Leprince , D Genty et al.

Journal of Spectroscopy, 2020, 35 (2), pp.34-40

Article dans une revue hal-02998713v1
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Aza-BODIPY: A New Vector for Enhanced Theranostic Boron Neutron Capture Therapy Applications

Ghadir Kalot , Amélie Godard , Benoît Busser , Jacques Pliquett , Mans Broekgaarden et al.

Cells, 2020, 9 (9), pp.1953. ⟨10.3390/cells9091953⟩

Article dans une revue inserm-02941457v1
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The Multifaceted Roles of Copper in Cancer: A Trace Metal Element with Dysregulated Metabolism, but Also a Target or a Bullet for Therapy

Pierre Lelièvre , Lucie Sancey , Jean-Luc Coll , Aurélien Deniaud , Benoit Busser

Cancers, 2020, 12 (12), pp.3594. ⟨10.3390/cancers12123594⟩

Article dans une revue hal-03113913v1
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Gold nanoclusters as a contrast agent for image-guided surgery of head and neck tumors

Cindy Colombé , Xavier Le Guével , Angela Martín-Serrano , Maxime Henry , Estelle Porret et al.

Nanomedicine: Nanotechnology, Biology and Medicine, 2019, 20, pp.102011. ⟨10.1016/j.nano.2019.04.014⟩

Article dans une revue hal-02355599v1
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L’imagerie élémentaire par spectroscopie LIBS : De nouvelles applications en médecine

Marine Leprince , Lucie Sancey , Jean-Luc Coll , Vincent Motto-Ros , Benoît Busser

Médecine/Sciences, 2019, 35 (8-9), pp.682-688. ⟨10.1051/medsci/2019132⟩

Article dans une revue hal-02367671v1

Laser-induced breakdown spectroscopy for human and animal health: A review

R. Gaudiuso , N. Melikechi , Z. A. Abdel-Salam , M. A. Harith , V. Palleschi et al.

Spectrochimica Acta Part B: Atomic Spectroscopy, 2019, 152, pp.123-148. ⟨10.1016/j.sab.2018.11.006⟩

Article dans une revue hal-02285880v1
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Development of molecular analyzes by digital PCR for clinical practice: positioning, current applications and perspectives

Jérôme Alexandre Denis , Alexandre Perrier , Juliette Nectoux , Pierre-Jean Lamy , Anne-Sophie Alary et al.

Annales de Biologie Clinique, 2019, 77 (6), pp.619-637. ⟨10.1684/abc.2019.1502⟩

Article dans une revue inserm-02992696v1
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The pyrrolopyrimidine colchicine-binding site agent PP-13 reduces the metastatic dissemination of invasive cancer cells in vitro and in vivo

Pauline Gilson , Morgane Couvet , Laetitia Vanwonterghem , Maxime Henry , Julien Vollaire et al.

Biochemical Pharmacology, 2019, 160, pp.1-13. ⟨10.1016/j.bcp.2018.12.004⟩

Article dans une revue hal-02347147v1

Sarcoïdoses et fibroses pulmonaires idiopathiques : les analyses minéralogiques par imagerie LIBS et MEB orientent le diagnostic étiologique

Benoit Busser , Mickaël Catinon , Marine Leprince , Frédéric Pelascini , Jean-Luc Coll et al.

Archives des Maladies Professionnelles et de L'Environnement, 2018, 79 (3), pp.420. ⟨10.1016/j.admp.2018.03.475⟩

Article dans une revue hal-02062820v1

Development of digital PCR molecular tests for clinical practice: principles, practical implementation and recommendations.

Jérôme Alexandre Denis , Juliette Nectoux , Pierre-Jean Lamy , Christelle Rouillac Le Sciellour , Hélène Guermouche et al.

Annales de Biologie Clinique, 2018, 76 (5), pp.505-523. ⟨10.1684/abc.2018.1372⟩

Article dans une revue hal-02353393v1
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Anticancer properties of lipid and poly(ε-caprolactone) nanocapsules loaded with ferrocenyl-tamoxifen derivatives

Feten Najlaoui , Pascal Pigeon , Sonia Aroui , Mylène Pezet , Lucie Sancey et al.

Journal of Pharmacy and Pharmacology, 2018, 70 (11), pp.1474-1484. ⟨10.1111/jphp.12998⟩

Article dans une revue hal-01861749v1

Elemental imaging using laser-induced breakdown spectroscopy: A new and promising approach for biological and medical applications

B. Busser , S. Moncayo , J. L. Coll , L. Sancey , Vincent Motto-Ros

Coordination Chemistry Reviews, 2018, 358, pp.70-79. ⟨10.1016/j.ccr.2017.12.006⟩

Article dans une revue istex hal-02287419v1
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Nuclear translocation of IGF1R by intracellular amphiregulin contributes to the resistance of lung tumour cells to EGFR-TKI

Marie Guerard , Thomas Robin , Pascal Perron , Anne-Sophie Hatat , Laurence David-Boudet et al.

Cancer Letters, 2018, 420, pp.146-155. ⟨10.1016/j.canlet.2018.01.080⟩

Article dans une revue inserm-02337427v1
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Plasma circulating tumor DNA levels for the monitoring of melanoma patients: landscape of available technologies and clinical applications

Benoit Busser , Julien Lupo , Lucie Sancey , Stéphane Mouret , Patrice Faure et al.

BioMed Research International , 2017, Part of Special Issue: Cancer Diagnostic and Predictive Biomarkers 2016, 2017, pp.5986129. ⟨10.1155/2017/5986129⟩

Article dans une revue hal-02059900v1
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Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer properties

Pauline Gilson , Fernando Josa-Prado , Claire Beauvineau , Delphine Naud-Martin , Laetitia Vanwonterghem et al.

Scientific Reports, 2017, 7 (1), pp.10209. ⟨10.1038/s41598-017-09491-9⟩

Article dans une revue inserm-01599698v2

Characterization of foreign materials in paraffin-embedded pathological specimens using in situ multi-elemental imaging with laser spectroscopy

Benoit Busser , Samuel Moncayo , Florian Trichard , Vincent Bonneterre , Nicole Pinel et al.

Modern Pathology, 2017, 31 (3), pp.378 - 384. ⟨10.1038/modpathol.2017.152⟩

Article dans une revue hal-01927018v1

Multi-elemental imaging of paraffin-embedded human samples by laser-induced breakdown spectroscopy

S. Moncayo , F. Trichard , B. Busser , M. Sabatier-Vincent , F. Pelascini et al.

Spectrochimica Acta Part B: Atomic Spectroscopy, 2017, 133, pp.40-44. ⟨10.1016/j.sab.2017.04.013⟩

Article dans une revue istex hal-02317555v1
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Efficacy of AKT Inhibitor ARQ 092 Compared with Sorafenib in a Cirrhotic Rat Model with Hepatocellular Carcinoma

Gaël S. Roth , Zuzana Jilkova , Ayca Zeybek Kuyucu , Keerthi Kurma , Ahmad Pour et al.

Molecular Cancer Therapeutics, 2017, 9, pp.2803. ⟨10.1158/1535-7163.MCT-16-0602-T⟩

Article dans une revue inserm-02333028v1
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3D Imaging of Nanoparticle Distribution in Biological Tissue by Laser-Induced Breakdown Spectroscopy

Y. Gimenez , B. Busser , F. Trichard , A. Kulesza , J. M. Laurent et al.

Scientific Reports, 2016, 6, pp.29936. ⟨10.1038/srep29936⟩

Article dans une revue hal-01405764v1
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Synergistic activity of vorinostat combined with gefitinib but not with sorafenib in mutant KRAS human non-small cell lung cancers and hepatocarcinoma

Victor Jeannot , Benoît Busser , Laetitia Vanwonterghem , Sophie Michallet , Sana Ferroudj et al.

OncoTargets and Therapy, 2016, 9, pp.6843-6855. ⟨10.2147/OTT.S117743⟩

Article dans une revue hal-02347748v1
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A Recombinant Fungal Lectin for Labeling Truncated Glycans on Human Cancer Cells

Aymeric Audfray , Mona Beldjoudi , Adrien Breiman , Amandine Hurbin , Irene Boos et al.

PLoS ONE, 2015, 10 (6), pp.e0128190. ⟨10.1371/journal.pone.0128190⟩

Article dans une revue hal-02349425v1
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Laser spectrometry for multi-elemental imaging of biological tissues

Lucie Sancey , Vincent Motto-Ros , B Busser , S Kotb , Jean-Michel Benoit et al.

Scientific Reports, 2014, 4, pp.6065. ⟨10.1038/srep06065⟩

Article dans une revue hal-01071458v1
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The PI3K/AKT pathway promotes gefitinib resistance in mutant KRAS lung adenocarcinoma by a deacetylase-dependent mechanism

Victor Jeannot , Benoît Busser , Elisabeth Brambilla , Marie Wislez , Blaise Robin et al.

International Journal of Cancer, 2014, 134 (11), pp.2560-2571. ⟨10.1002/ijc.28594⟩

Article dans une revue hal-02349444v1

Comparison of COBAS 4800 KRAS, TaqMan PCR and High Resolution Melting PCR assays for the detection of KRAS somatic mutations in formalin-fixed paraffin embedded colorectal carcinomas

Alexandre Harlé , Benoît Busser , Marie Rouyer , Valentin Harter , Pascal Genin et al.

Virchows Archiv, 2013, 462 (3), pp.329-335. ⟨10.1007/s00428-013-1380-x⟩

Article dans une revue istex hal-00733883v1
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The multiple roles of amphiregulin in human cancer.

Benoit Busser , Lucie Sancey , Elisabeth Brambilla , Jean-Luc Coll , Amandine Hurbin

Biochimica et Biophysica Acta - Molecular Cell Research, 2011, 1816 (2), pp.119-131. ⟨10.1016/j.bbcan.2011.05.003⟩

Article dans une revue inserm-00602082v1
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Insulin-like growth factor-1 receptor inhibition overcomes gefitinib resistance in mucinous lung adenocarcinoma.

Amandine Hurbin , Marie Wislez , Benoît Busser , Martine Antoine , Corine Tenaud et al.

Journal of Pathology, 2011, 225 (1), pp.83-95. ⟨10.1002/path.2897⟩

Article dans une revue istex inserm-00598462v1
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Amphiregulin promotes resistance to gefitinib in nonsmall cell lung cancer cells by regulating Ku70 acetylation.

Benoît Busser , Lucie Sancey , Véronique Josserand , Carole Niang , Saadi Khochbin et al.

Molecular Therapy, 2010, 18 (3), pp.536-43. ⟨10.1038/mt.2009.227⟩

Article dans une revue inserm-00425467v1
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Amphiregulin promotes BAX inhibition and resistance to gefitinib in non-small-cell lung cancers.

Benoît Busser , Lucie Sancey , Véronique Josserand , Carole Niang , Marie C. Favrot et al.

Molecular Therapy, 2010, 18 (3), pp.528-35. ⟨10.1038/mt.2009.226⟩

Article dans une revue inserm-00425468v1
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The increasing role of amphiregulin in non-small cell lung cancer.

Benoît Busser , Jean-Luc Coll , Amandine Hurbin

Pathologie Biologie, 2009, 57 (7-8), pp.511-2. ⟨10.1016/j.patbio.2008.10.002⟩

Article dans une revue inserm-00333661v1

Unlocking the anticancer potential of calix[4]arene-based Cu(I) ionophores in vitro and in vivo

Pierre Lelièvre , Cyril Nogier , Jean-Luc Coll , Ivan Jabin , Lucie Sancey et al.

Annual Meeting of the American-Association-for-Cancer-Research (AACR), Apr 2024, San Diego, Californie, United States. CANCER RESEARCH, 84 (6_Supplement), pp.4681., 2024, ⟨10.1158/1538-7445.AM2024-4681⟩

Poster de conférence hal-04771974v1

Discovery of phalbinib, a novel anticancer compound targeting copper homeostasis and inducing cell cycle arrest and autophagy

Pierre Lelievre , Cyril Nogier , Nathan Renier , Jean-Luc Coll , Ivan Jabin et al.

Annual congress of the European Association for Cancer Research (EACR-2023), Jun 2023, Turin, Italy

Poster de conférence hal-04959503v1

LIBS imaging applications

V. Motto-Ros , S. Moncayo , C. Fabre , B. Busser

Laser-Induced Breakdown Spectroscopy, Elsevier, pp.329-346, 2020, ⟨10.1016/B978-0-12-818829-3.00014-9⟩

Chapitre d'ouvrage hal-03672496v1