caterina casari

Researcher
55
Documents
Affiliation actuelle
  • Hémostase, Inflammation, Thrombose (HITH - U1176 Inserm - CHU Bicêtre)
Identifiants chercheurs
Contact

Présentation

I am a tenured researcher in France at the Inserm Unit 1176, Hemostasis, Inflammation and Thrombosis laboratory. My research studies focus on von Willebrand factor and its partners. I am interested in developing in vitro & in vivo models to elucidate molecular mechanisms underlying unsolved clinical aspects of congenital and acquired von Willebrand disease. I am also interested in exploring new therapeutic approaches for VWF-associated disorders.

Domaines de recherche

Sciences du Vivant [q-bio]

Publications

Publications

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A bispecific nanobody for the treatment of von Willebrand disease type 1

Ivan Peyron , Caterina Casari , Geneviève Mccluskey , Stéphanie Roullet , Vincent Licari et al. Article dans une revue hal-05263486v1
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A fully humanized von Willebrand disease type 1 mouse model as unique platform to investigate novel therapeutic options

Geneviève Mccluskey , Marco Heestermans , Ivan Peyron , Eloise Pascal , Marie Clavel et al.

Haematologica, In press, ⟨10.3324/haematol.2024.286076⟩

Article dans une revue (data paper) hal-04871911v1

Clinical, Phenotypic and Genotypic Characteristics of Von Willebrand Disease in Afro‐Caribbeans: Results From a Study in Martinique Island, French West Indies

Marie‐daniéla Dubois , Olivier Nicolas Pierre-Louis , Serge Pierre-Louis , Pierre Boisseau , Cécile Denis et al.

Haemophilia, 2025, 31 (3), pp.458-476. ⟨10.1111/hae.70003⟩

Article dans une revue hal-05306019v1

Alternative AAV gene therapy for hemophilia A using expression of Bi8, a novel single-chain FVIII-mimetic antibody

Vincent Muczynski , Olivier Christophe , Lewis Tanner , Charlotte Vayssiere , Alice Guérin et al. Article dans une revue hal-05299843v1

Historical, current and future treatments for von Willebrand disease

Caterina Casari , Frank W.G. Leebeek , Flora Peyvandi

Haematologica, 2025, 111 (1), pp.54-66. ⟨10.3324/haematol.2024.286037⟩

Article dans une revue hal-05458832v1

Advances in Von Willebrand Disease

Riitta Lassila , Ferdows Atiq , Caterina Casari , Michelle Lavin

Haemophilia, 2025, ⟨10.1111/hae.70192⟩

Article dans une revue hal-05458829v1

Amelioration of a von Willebrand disease type 2B phenotype in vivo upon treatment with allele-selective siRNAs

Noa Linthorst , Yvonne Jongejan , Richard Dirven , Sebastiaan Laan , Ruben Bierings et al.

Blood Advances, 2025, 9 (2), pp.310-320. ⟨10.1182/bloodadvances.2024014601⟩

Article dans une revue hal-05045746v1
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Differences in venous clot structures between hemophilic mice treated with emicizumab versus factor VIII or factor VIIIFc

Thibaud Sefiane , Hortense Maynadié , Carmen Escurola Ettingshausen , Vincent Muczynski , Xavier Heiligenstein et al.

Haematologica, 2024, ⟨10.3324/haematol.2023.284142⟩

Article dans une revue hal-04449388v1
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Fitusiran reduces bleeding in factor X–deficient mice

Sebastien Verhenne , Geneviève Mccluskey , Hortense Maynadié , Frédéric Adam , Caterina Casari et al.

Blood, 2024, 144 (2), pp.227-236. ⟨10.1182/blood.2023023404⟩

Article dans une revue hal-04654300v1

Development of a dual hybrid AAV vector for endothelial-targeted expression of von Willebrand factor

Elena Barbon , Charlotte Kawecki , Solenne Marmier , Aboud Sakkal , Fanny Collaud et al.

Gene Therapy, 2023, 30 (3-4), pp.245-254. ⟨10.1038/s41434-020-00218-6⟩

Article dans une revue hal-04455812v1
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New and emerging therapies for women, girls, and people with the potential to menstruate with VWD

Caterina Casari , Jennifer Leung , Paula D James

Blood Advances, 2023, 7 (24), pp.7501-7505. ⟨10.1182/bloodadvances.2023010716⟩

Article dans une revue (article de synthèse) hal-04456643v1
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Efficacy of platelet-inspired hemostatic nanoparticles on bleeding in Von Willebrand disease murine models

Stéphanie Roullet , Norman Luc , Julie Rayes , Jean Solarz , Dante Disharoon et al.

Blood, 2023, 141 (23), pp.2891-2900. ⟨10.1182/blood.2022018956⟩

Article dans une revue inserm-04066466v1
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Modèles murins en hémostase

Cécile Denis , Caterina Casari , Stéphanie Roullet

Hématologie, 2023, 29 (6), pp.338-353. ⟨10.1684/hma.2023.1827⟩

Article dans une revue (article de synthèse) hal-04457009v1
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A nanobody against the VWF A3 domain detects ADAMTS13-induced proteolysis in congenital and acquired VWD

Claire Kizlik-Masson , Ivan Peyron , Stéphane Gangnard , Gaelle Le Goff , Solen Lenoir et al.

Blood, 2023, 141 (12), pp.1457-1468. ⟨10.1182/blood.2022017569⟩

Article dans une revue inserm-04258451v1

Shear Force-Induced Platelet Clearance Is a New Mechanism of Thrombocytopenia

Antoine Rauch , Annabelle Dupont , Mickael Rosa , Maximilien Desvages , Christina Le Tanno et al.

Circulation Research, 2023, 133 (10), pp.826-841. ⟨10.1161/CIRCRESAHA.123.322752⟩

Article dans une revue hal-04455871v1
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Shear forces induced platelet clearance is a new mechanism of thrombocytopenia

Antoine Rauch , Annabelle Dupont , Mickael Rosa , Maximilien Desvages , Christina Le Tanno et al.

Circulation Research, 2023, 133 (10), pp.826-841. ⟨10.1161/CIRCRESAHA.123.322752⟩

Article dans une revue hal-04352553v1
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A thrombopoietin receptor agonist to rescue an unusual platelet transfusion-induced reaction in a p.V1316M-associated von Willebrand disease type 2B patient

Caterina Casari , Remi Favier , Paulette Legendre , Alexandre Kauskot , Frederic Adam et al.

Therapeutic Advances in Hematology, 2022, 13, pp.204062072210768. ⟨10.1177/20406207221076812⟩

Article dans une revue hal-04455865v1
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Cerebral Microbleeds During Transcatheter Aortic Valve Replacement: A Prospective Magnetic Resonance Imaging Cohort

Eric van Belle , Nicolas Debry , Flavien Vincent , Grégory Kuchcinski , Charlotte Cordonnier et al.

Circulation, 2022, 146 (5), pp.383-397. ⟨10.1161/CIRCULATIONAHA.121.057145⟩

Article dans une revue hal-04354020v1
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Identification of von Willebrand factor D4 domain mutations in patients of Afro‐Caribbean descent: In vitro characterization

Marie‐daniéla Dubois , Ivan Peyron , Olivier‐nicolas Pierre-Louis , Serge Pierre-Louis , Johalène Rabout et al.

Research and Practice in Thrombosis and Haemostasis, 2022, 6 (4), pp.e12737. ⟨10.1002/rth2.12737⟩

Article dans une revue hal-04354187v1

Challenges facing early career women in thrombosis and hemostasis—meeting the needs of the next generation

Lauren Poole , Caterina Casari , Sofija Dunjic Manevski , Renee Eslick , Jeffrey Weitz et al.

Journal of Thrombosis and Haemostasis, 2022, 20 (11), pp.2453-2455. ⟨10.1111/jth.15895⟩

Article dans une revue hal-04455915v1

Identification of von Willebrand factor D4 domain mutations in patients of Afro‐Caribbean descent: In vitro characterization

Marie‐daniéla Dubois , Ivan Peyron , Olivier‐nicolas Pierre-Louis , Serge Pierre-Louis , Johalène Rabout et al.

Research and Practice in Thrombosis and Haemostasis, 2022, 6 (4), pp.e12737. ⟨10.1002/rth2.12737⟩

Article dans une revue hal-05306074v1

Rasa3 deficiency minimally affects thrombopoiesis but promotes severe thrombocytopenia due to integrin-dependent platelet clearance

Robert Lee , Dorsaf Ghalloussi , Gabriel Harousseau , Joseph Kenny , Patrick Kramer et al.

JCI Insight, 2022, 7 (8), ⟨10.1172/jci.insight.155676⟩

Article dans une revue hal-04455805v1
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Development of a dual hybrid AAV vector for endothelial-targeted expression of von Willebrand factor

Elena Barbon , Charlotte Kawecki , Solenne Marmier , Aboud Sakkal , Fanny Collaud et al.

Gene Therapy, 2021, 30 (3-4), pp.245-254. ⟨10.1038/s41434-020-00218-6⟩

Article dans une revue (data paper) hal-04324328v1
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A compact integrated microfluidic oxygenator with high gas exchange efficiency and compatibility for long-lasting endothelialization

Julie Lachaux , Gilgueng Hwang , Nassim Arouche , Sina Naserian , Abdelmounaim Harouri et al.

Lab on a Chip, In press, ⟨10.1039/d1lc00356a⟩

Article dans une revue hal-03318488v1

A compact integrated microfluidic oxygenator with high gas exchange efficiency and compatibility for long-lasting endothelialization

Julie Lachaux , Gilgueng Hwang , Nassim Arouche , Sina Naserian , Abdelmounaim Harouri et al.

Lab on a Chip, 2021, 21 (24), pp.4791-4804. ⟨10.1039/d1lc00356a⟩

Article dans une revue hal-03853585v1

Camelid‐derived single‐chain antibodies in hemostasis: Mechanistic, diagnostic, and therapeutic applications

Ivan Peyron , Claire Kizlik-Masson , Marie-Daniéla Dubois , Sénadé Atsou , Stephen Ferrière et al.

Research and Practice in Thrombosis and Haemostasis, 2020, 4 (7), pp.1087-1100. ⟨10.1002/rth2.12420⟩

Article dans une revue hal-05320380v1
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Single‐domain antibodies targeting antithrombin reduce bleeding in hemophilic mice with or without inhibitors

Elena Barbon , Gabriel Ayme , Amel Mohamadi , Jean-François Ottavi , Charlotte Kawecki et al.

EMBO Molecular Medicine, 2020, 12 (4), pp.e11298. ⟨10.15252/emmm.201911298⟩

Article dans une revue inserm-02551254v1
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A hemophilia A mouse model for the in vivo assessment of emicizumab function

Stephen Ferrière , Ivan Peyron , Olivier D. Christophe , Charlotte Kawecki , Caterina Casari et al.

Blood, 2020, 136 (6), pp.740-748. ⟨10.1182/blood.2019004334⟩

Article dans une revue inserm-02916896v1
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In vivo modulation of a dominant‐negative variant in mouse models of von Willebrand disease type 2A

Matteo Campioni , Paulette Legendre , Cécile Loubiere , Barbara Lunghi , Mirko Pinotti et al.

Journal of Thrombosis and Haemostasis, 2020, Online ahead of print. ⟨10.1111/jth.15131⟩

Article dans une revue (data paper) inserm-02983110v1
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Camelid‐derived single‐chain antibodies in hemostasis: Mechanistic, diagnostic, and therapeutic applications

Ivan Peyron , Claire Kizlik‐masson , Marie‐daniéla Dubois , Sénadé Atsou , Stephen Ferrière et al.

Research and Practice in Thrombosis and Haemostasis, 2020, 4 (7), pp.1087-1110. ⟨10.1002/rth2.12420⟩

Article dans une revue hal-03116405v1

A Thrombin-Activatable Factor X Variant Corrects Hemostasis in a Mouse Model for Hemophilia A

Vincent Muczynski , Sebastien Verhenne , Caterina Casari , Ghislaine Chérel , Laurence Panicot-Dubois et al.

Thrombosis and Haemostasis, 2019, 119 (12), pp.1981-1993. ⟨10.1055/s-0039-1697662⟩

Article dans une revue hal-02570572v1

Weibel-Palade Bodies Orchestrate Pericytes During Angiogenesis

Mélissande Cossutta , Marie Darche , Gilles Carpentier , Claire Houppe , Matteo Ponzo et al.

Arteriosclerosis, Thrombosis, and Vascular Biology, 2019, 39 (9), pp.1843-1858. ⟨10.1161/ATVBAHA.119.313021⟩

Article dans une revue hal-02347222v1

Weibel-Palade Bodies Orchestrate Pericytes During Angiogenesis

Mélissande Cossutta , Marie Darche , Gilles Carpentier , Claire Houppe , Matteo Ponzo et al.

Arteriosclerosis, Thrombosis, and Vascular Biology, 2019, 39 (9), pp.1843-1858. ⟨10.1161/ATVBAHA.119.313021⟩

Article dans une revue hal-03095533v1
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A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation

Vincent Muczynski , Caterina Casari , François Moreau , Gabriel Aymé , Charlotte Kawecki et al.

Blood, 2018, 132 (11), pp.1193-1197. ⟨10.1182/blood-2018-01-829523⟩

Article dans une revue (data paper) hal-04456589v1

Macrophage scavenger receptor SR-AI contributes to the clearance of von Willebrand factor

Nikolett Wohner , Vincent Muczynski , Amel Mohamadi , Paulette Legendre , Valérie Proulle et al.

Haematologica, 2018, 103 (4), pp.728-737. ⟨10.3324/haematol.2017.175216⟩

Article dans une revue pasteur-03209471v1

A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation

Vincent Muczynski , Caterina Casari , François Moreau , Gabriel Ayme , Charlotte Kawecki et al.

Blood, 2018, 132 (11), pp.1193-1197. ⟨10.1182/blood-2018-01-829523⟩

Article dans une revue hal-03209466v1

LIM kinase/cofilin dysregulation promotes macrothrombocytopenia in severe von Willebrand disease-type 2B

Alexandre Kauskot , Sonia Poirault-Chassac , Frédéric Adam , Vincent Muczynski , Gabriel Ayme et al.

JCI Insight, 2016, 1 (16), pp.e88643. ⟨10.1172/jci.insight.88643⟩

Article dans une revue hal-03209475v1

Novel VWD Treatment

Caterina Casari

WFH Comprehensive Core Summit, Apr 2025, Dubai, United Arab Emirates. Haemophilia, 2025, ⟨10.1111/hae.70031⟩

Proceedings/Recueil des communications hal-05051691v1

A consistent in vivo factor VIII-equivalence is unlikely to exist for non-factor therapies

Hortense Maynadié , Thibaud Sefiane , Genevieve Mccluskey , Marie Clavel , Ivan Peyron et al.

Congrès Français d'Hémostase, Société Française de Thrombose et d'Hémostase, Sep 2024, Lille, France

Communication dans un congrès hal-04701045v1

Fitusiran-treatment modulates the ratio between alpha- and beta-antithrombin isoforms

Geneviève Mccluskey , Hortense Maynadié , Caterina Casari , Delphine Borgel , Laurent Frenzel et al.

Congrès Français d'Hémostase, Société Française de Thrombose et d'Hémostase, Sep 2024, Lille, France

Communication dans un congrès hal-04701035v1

Experimental and clinical rationale for the use of bispecific antibodies in von Willebrand disease

Caterina Casari

Bari International Conference BIC, Sep 2023, Palerme, Italy

Communication dans un congrès hal-04459634v1

Update on KB-V13A12 & SynthoPlates

Caterina Casari

EHC Workshop in New technologies in rare bleeding disorders, Nov 2023, Cascais, Portugal

Communication dans un congrès hal-04459645v1

Novel Therapeutics for VWD

Caterina Casari

International Society of Thrombosis and Haemostasis ISTH, Jun 2023, Montreal, Canada. ⟨10.1016/j.rpth.2023.100193⟩

Communication dans un congrès hal-04459623v1

Future therapies for von Willebrand disease

Caterina Casari

16th European Association for Haemophilia and Allied Disorders (EAHAD), Feb 2023, Manchester, United Kingdom. pp.5-13, ⟨10.1111/hae.14713⟩

Communication dans un congrès hal-04459575v1

Antibodies for VWD

Caterina Casari

EHC Workshop in New technologies in rare bleeding disorders, Nov 2023, Cascais, Portugal

Communication dans un congrès hal-04459657v1

Bon vent pour les patients avec la maladie de Willebrand?

Caterina Casari

Congrès Français d’Hémostase (CFH), May 2023, St Malo, France

Communication dans un congrès hal-04459610v1

Antibody-based strategies as potential new treatments for von Willebrand Disease

Caterina Casari

65th ASH Annual Meeting, Dec 2023, San Diego, United States

Communication dans un congrès hal-04459665v1

Tailored treatments for VWD

Caterina Casari

EHC Annual Conference, Oct 2021, Virtual conference, Belgium

Communication dans un congrès hal-04459561v1

Future therapies in von Willebrand disease: time for a tailored fit?

Caterina Casari

Bari International Conference BIC, Sep 2021, Venezia, Italy

Communication dans un congrès hal-04459526v1

New Treatment Options for VWD

Caterina Casari

International Society of Thrombosis and Haemostasis ISTH, Jul 2021, Philadelphia - online, United States

Communication dans un congrès hal-04459485v1

Vecchi e nuovi percorsi del bus molecolare: il fattore di von Willebrand

Caterina Casari

XXVI SISET, Nov 2020, Baveno - online, Italy

Communication dans un congrès hal-04459467v1

Dégradation du facteur Willebrand et syndrome de Willebrand acquis: Utilisation des dispositifs de support mécanique

Caterina Casari

GFHT 2019, Sep 2019, Montpellier, France

Communication dans un congrès hal-04459451v1