caterina casari

53
Documents
Affiliation actuelle
  • Hémostase, Inflammation, Thrombose (HITH - U1176 Inserm - CHU Bicêtre)
Identifiants chercheurs
Contact

Présentation

I am a tenured researcher in France at the Inserm Unit 1176, Hemostasis, Inflammation and Thrombosis laboratory. My research studies focus on von Willebrand factor and its partners. I am interested in developing in vitro & in vivo models to elucidate molecular mechanisms underlying unsolved clinical aspects of congenital and acquired von Willebrand disease. I am also interested in exploring new therapeutic approaches for VWF-associated disorders.

Domaines de recherche

Sciences du Vivant [q-bio]

Publications

Publications

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A fully humanized von Willebrand disease type 1 mouse model as unique platform to investigate novel therapeutic options

Geneviève Mccluskey , Marco Heestermans , Ivan Peyron , Eloise Pascal , Marie Clavel et al.
Haematologica, In press, ⟨10.3324/haematol.2024.286076⟩
Article dans une revue (data paper) hal-04871911 v1

Alternative AAV gene therapy for hemophilia A using expression of Bi8, a novel single-chain FVIII-mimetic antibody

Vincent Muczynski , Olivier Christophe , Lewis Tanner , Charlotte Vayssiere , Alice Guérin et al.
Article dans une revue hal-05299843 v1
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A bispecific nanobody for the treatment of von Willebrand disease type 1

Ivan Peyron , Caterina Casari , Geneviève Mccluskey , Stéphanie Roullet , Vincent Licari et al.
Article dans une revue hal-05263486 v1

Clinical, Phenotypic and Genotypic Characteristics of Von Willebrand Disease in Afro‐Caribbeans: Results From a Study in Martinique Island, French West Indies

Marie‐daniéla Dubois , Olivier Nicolas Pierre-Louis , Serge Pierre-Louis , Pierre Boisseau , Cécile Denis et al.
Haemophilia, 2025, 31 (3), pp.458-476. ⟨10.1111/hae.70003⟩
Article dans une revue hal-05306019 v1

Amelioration of a von Willebrand disease type 2B phenotype in vivo upon treatment with allele-selective siRNAs

Noa Linthorst , Yvonne Jongejan , Richard Dirven , Sebastiaan Laan , Ruben Bierings et al.
Blood Advances, 2025, 9 (2), pp.310-320. ⟨10.1182/bloodadvances.2024014601⟩
Article dans une revue hal-05045746 v1
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Differences in venous clot structures between hemophilic mice treated with emicizumab versus factor VIII or factor VIIIFc

Thibaud Sefiane , Hortense Maynadié , Carmen Escurola Ettingshausen , Vincent Muczynski , Xavier Heiligenstein et al.
Article dans une revue hal-04449388 v1
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Fitusiran reduces bleeding in factor X–deficient mice

Sebastien Verhenne , Geneviève Mccluskey , Hortense Maynadié , Frédéric Adam , Caterina Casari et al.
Blood, 2024, 144 (2), pp.227-236. ⟨10.1182/blood.2023023404⟩
Article dans une revue hal-04654300 v1
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Modèles murins en hémostase

Cécile Denis , Caterina Casari , Stéphanie Roullet
Hématologie, 2023, 29 (6), pp.338-353. ⟨10.1684/hma.2023.1827⟩
Article dans une revue (article de synthèse) hal-04457009 v1
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A nanobody against the VWF A3 domain detects ADAMTS13-induced proteolysis in congenital and acquired VWD

Claire Kizlik-Masson , Ivan Peyron , Stéphane Gangnard , Gaelle Le Goff , Solen Lenoir et al.
Blood, 2023, 141 (12), pp.1457-1468. ⟨10.1182/blood.2022017569⟩
Article dans une revue inserm-04258451 v1

Shear Force-Induced Platelet Clearance Is a New Mechanism of Thrombocytopenia

Antoine Rauch , Annabelle Dupont , Mickael Rosa , Maximilien Desvages , Christina Le Tanno et al.
Circulation Research, 2023, 133 (10), pp.826-841. ⟨10.1161/CIRCRESAHA.123.322752⟩
Article dans une revue hal-04455871 v1
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Shear forces induced platelet clearance is a new mechanism of thrombocytopenia

Antoine Rauch , Annabelle Dupont , Mickael Rosa , Maximilien Desvages , Christina Le Tanno et al.
Circulation Research, 2023, 133 (10), pp.826-841. ⟨10.1161/CIRCRESAHA.123.322752⟩
Article dans une revue hal-04352553 v1
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Efficacy of platelet-inspired hemostatic nanoparticles on bleeding in Von Willebrand disease murine models

Stéphanie Roullet , Norman Luc , Julie Rayes , Jean Solarz , Dante Disharoon et al.
Blood, 2023, 141 (23), pp.2891-2900. ⟨10.1182/blood.2022018956⟩
Article dans une revue inserm-04066466 v1

Development of a dual hybrid AAV vector for endothelial-targeted expression of von Willebrand factor

Elena Barbon , Charlotte Kawecki , Solenne Marmier , Aboud Sakkal , Fanny Collaud et al.
Gene Therapy, 2023, 30 (3-4), pp.245-254. ⟨10.1038/s41434-020-00218-6⟩
Article dans une revue hal-04455812 v1
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New and emerging therapies for women, girls, and people with the potential to menstruate with VWD

Caterina Casari , Jennifer Leung , Paula D James
Blood Advances, 2023, 7 (24), pp.7501-7505. ⟨10.1182/bloodadvances.2023010716⟩
Article dans une revue (article de synthèse) hal-04456643 v1

Challenges facing early career women in thrombosis and hemostasis—meeting the needs of the next generation

Lauren Poole , Caterina Casari , Sofija Dunjic Manevski , Renee Eslick , Jeffrey Weitz et al.
Journal of Thrombosis and Haemostasis, 2022, 20 (11), pp.2453-2455. ⟨10.1111/jth.15895⟩
Article dans une revue hal-04455915 v1
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Cerebral Microbleeds During Transcatheter Aortic Valve Replacement: A Prospective Magnetic Resonance Imaging Cohort

Eric van Belle , Nicolas Debry , Flavien Vincent , Grégory Kuchcinski , Charlotte Cordonnier et al.
Circulation, 2022, 146 (5), pp.383-397. ⟨10.1161/CIRCULATIONAHA.121.057145⟩
Article dans une revue hal-04354020 v1
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Identification of von Willebrand factor D4 domain mutations in patients of Afro‐Caribbean descent: In vitro characterization

Marie‐daniéla Dubois , Ivan Peyron , Olivier‐nicolas Pierre-Louis , Serge Pierre-Louis , Johalène Rabout et al.
Research and Practice in Thrombosis and Haemostasis, 2022, 6 (4), pp.e12737. ⟨10.1002/rth2.12737⟩
Article dans une revue hal-04354187 v1

Rasa3 deficiency minimally affects thrombopoiesis but promotes severe thrombocytopenia due to integrin-dependent platelet clearance

Robert Lee , Dorsaf Ghalloussi , Gabriel Harousseau , Joseph Kenny , Patrick Kramer et al.
JCI Insight, 2022, 7 (8), ⟨10.1172/jci.insight.155676⟩
Article dans une revue hal-04455805 v1

Identification of von Willebrand factor D4 domain mutations in patients of Afro‐Caribbean descent: In vitro characterization

Marie‐daniéla Dubois , Ivan Peyron , Olivier‐nicolas Pierre-Louis , Serge Pierre-Louis , Johalène Rabout et al.
Research and Practice in Thrombosis and Haemostasis, 2022, 6 (4), pp.e12737. ⟨10.1002/rth2.12737⟩
Article dans une revue hal-05306074 v1
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A thrombopoietin receptor agonist to rescue an unusual platelet transfusion-induced reaction in a p.V1316M-associated von Willebrand disease type 2B patient

Caterina Casari , Remi Favier , Paulette Legendre , Alexandre Kauskot , Frederic Adam et al.
Therapeutic Advances in Hematology, 2022, 13, pp.204062072210768. ⟨10.1177/20406207221076812⟩
Article dans une revue hal-04455865 v1
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A compact integrated microfluidic oxygenator with high gas exchange efficiency and compatibility for long-lasting endothelialization

Julie Lachaux , Gilgueng Hwang , Nassim Arouche , Sina Naserian , Abdelmounaim Harouri et al.
Lab on a Chip, In press, ⟨10.1039/d1lc00356a⟩
Article dans une revue hal-03318488 v1

A compact integrated microfluidic oxygenator with high gas exchange efficiency and compatibility for long-lasting endothelialization

Julie Lachaux , Gilgueng Hwang , Nassim Arouche , Sina Naserian , Abdelmounaim Harouri et al.
Lab on a Chip, 2021, 21 (24), pp.4791-4804. ⟨10.1039/d1lc00356a⟩
Article dans une revue hal-03853585 v1
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Development of a dual hybrid AAV vector for endothelial-targeted expression of von Willebrand factor

Elena Barbon , Charlotte Kawecki , Solenne Marmier , Aboud Sakkal , Fanny Collaud et al.
Gene Therapy, 2021, 30 (3-4), pp.245-254. ⟨10.1038/s41434-020-00218-6⟩
Article dans une revue (data paper) hal-04324328 v1

Camelid‐derived single‐chain antibodies in hemostasis: Mechanistic, diagnostic, and therapeutic applications

Ivan Peyron , Claire Kizlik-Masson , Marie-Daniéla Dubois , Sénadé Atsou , Stephen Ferrière et al.
Research and Practice in Thrombosis and Haemostasis, 2020, 4 (7), pp.1087-1100. ⟨10.1002/rth2.12420⟩
Article dans une revue hal-05320380 v1
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Single‐domain antibodies targeting antithrombin reduce bleeding in hemophilic mice with or without inhibitors

Elena Barbon , Gabriel Ayme , Amel Mohamadi , Jean-François Ottavi , Charlotte Kawecki et al.
EMBO Molecular Medicine, 2020, 12 (4), pp.e11298. ⟨10.15252/emmm.201911298⟩
Article dans une revue inserm-02551254 v1
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A hemophilia A mouse model for the in vivo assessment of emicizumab function

Stephen Ferrière , Ivan Peyron , Olivier D. Christophe , Charlotte Kawecki , Caterina Casari et al.
Blood, 2020, 136 (6), pp.740-748. ⟨10.1182/blood.2019004334⟩
Article dans une revue inserm-02916896 v1
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In vivo modulation of a dominant‐negative variant in mouse models of von Willebrand disease type 2A

Matteo Campioni , Paulette Legendre , Cécile Loubiere , Barbara Lunghi , Mirko Pinotti et al.
Journal of Thrombosis and Haemostasis, 2020, Online ahead of print. ⟨10.1111/jth.15131⟩
Article dans une revue (data paper) inserm-02983110 v1
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Camelid‐derived single‐chain antibodies in hemostasis: Mechanistic, diagnostic, and therapeutic applications

Ivan Peyron , Claire Kizlik‐masson , Marie‐daniéla Dubois , Sénadé Atsou , Stephen Ferrière et al.
Research and Practice in Thrombosis and Haemostasis, 2020, 4 (7), pp.1087-1110. ⟨10.1002/rth2.12420⟩
Article dans une revue hal-03116405 v1

Weibel-Palade Bodies Orchestrate Pericytes During Angiogenesis

Mélissande Cossutta , Marie Darche , Gilles Carpentier , Claire Houppe , Matteo Ponzo et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2019, 39 (9), pp.1843-1858. ⟨10.1161/ATVBAHA.119.313021⟩
Article dans une revue hal-03095533 v1

A Thrombin-Activatable Factor X Variant Corrects Hemostasis in a Mouse Model for Hemophilia A

Vincent Muczynski , Sebastien Verhenne , Caterina Casari , Ghislaine Chérel , Laurence Panicot-Dubois et al.
Thrombosis and Haemostasis, 2019, 119 (12), pp.1981-1993. ⟨10.1055/s-0039-1697662⟩
Article dans une revue hal-02570572 v1

Weibel-Palade Bodies Orchestrate Pericytes During Angiogenesis

Mélissande Cossutta , Marie Darche , Gilles Carpentier , Claire Houppe , Matteo Ponzo et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2019, 39 (9), pp.1843-1858. ⟨10.1161/ATVBAHA.119.313021⟩
Article dans une revue hal-02347222 v1

Macrophage scavenger receptor SR-AI contributes to the clearance of von Willebrand factor

Nikolett Wohner , Vincent Muczynski , Amel Mohamadi , Paulette Legendre , Valérie Proulle et al.
Haematologica, 2018, 103 (4), pp.728-737. ⟨10.3324/haematol.2017.175216⟩
Article dans une revue pasteur-03209471 v1

A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation

Vincent Muczynski , Caterina Casari , François Moreau , Gabriel Ayme , Charlotte Kawecki et al.
Blood, 2018, 132 (11), pp.1193-1197. ⟨10.1182/blood-2018-01-829523⟩
Article dans une revue pasteur-03209466 v1
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A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation

Vincent Muczynski , Caterina Casari , François Moreau , Gabriel Aymé , Charlotte Kawecki et al.
Blood, 2018, 132 (11), pp.1193-1197. ⟨10.1182/blood-2018-01-829523⟩
Article dans une revue (data paper) hal-04456589 v1

LIM kinase/cofilin dysregulation promotes macrothrombocytopenia in severe von Willebrand disease-type 2B

Alexandre Kauskot , Sonia Poirault-Chassac , Frédéric Adam , Vincent Muczynski , Gabriel Ayme et al.
JCI Insight, 2016, 1 (16), pp.e88643. ⟨10.1172/jci.insight.88643⟩
Article dans une revue hal-03209475 v1

Novel VWD Treatment

Caterina Casari
WFH Comprehensive Core Summit, Apr 2025, Dubai, United Arab Emirates. Haemophilia, 2025, ⟨10.1111/hae.70031⟩
Proceedings/Recueil des communications hal-05051691 v1

A consistent in vivo factor VIII-equivalence is unlikely to exist for non-factor therapies

Hortense Maynadié , Thibaud Sefiane , Genevieve Mccluskey , Marie Clavel , Ivan Peyron et al.
Congrès Français d'Hémostase, Société Française de Thrombose et d'Hémostase, Sep 2024, Lille, France
Communication dans un congrès hal-04701045 v1

Fitusiran-treatment modulates the ratio between alpha- and beta-antithrombin isoforms

Geneviève Mccluskey , Hortense Maynadié , Caterina Casari , Delphine Borgel , Laurent Frenzel et al.
Congrès Français d'Hémostase, Société Française de Thrombose et d'Hémostase, Sep 2024, Lille, France
Communication dans un congrès hal-04701035 v1

Future therapies for von Willebrand disease

Caterina Casari
16th European Association for Haemophilia and Allied Disorders (EAHAD), Feb 2023, Manchester, United Kingdom. pp.5-13, ⟨10.1111/hae.14713⟩
Communication dans un congrès hal-04459575 v1

Novel Therapeutics for VWD

Caterina Casari
International Society of Thrombosis and Haemostasis ISTH, Jun 2023, Montreal, Canada. ⟨10.1016/j.rpth.2023.100193⟩
Communication dans un congrès hal-04459623 v1

Antibodies for VWD

Caterina Casari
EHC Workshop in New technologies in rare bleeding disorders, Nov 2023, Cascais, Portugal
Communication dans un congrès hal-04459657 v1

Update on KB-V13A12 & SynthoPlates

Caterina Casari
EHC Workshop in New technologies in rare bleeding disorders, Nov 2023, Cascais, Portugal
Communication dans un congrès hal-04459645 v1

Bon vent pour les patients avec la maladie de Willebrand?

Caterina Casari
Congrès Français d’Hémostase (CFH), May 2023, St Malo, France
Communication dans un congrès hal-04459610 v1

Antibody-based strategies as potential new treatments for von Willebrand Disease

Caterina Casari
65th ASH Annual Meeting, Dec 2023, San Diego, United States
Communication dans un congrès hal-04459665 v1

Experimental and clinical rationale for the use of bispecific antibodies in von Willebrand disease

Caterina Casari
Bari International Conference BIC, Sep 2023, Palerme, Italy
Communication dans un congrès hal-04459634 v1

Tailored treatments for VWD

Caterina Casari
EHC Annual Conference, Oct 2021, Virtual conference, Belgium
Communication dans un congrès hal-04459561 v1

Future therapies in von Willebrand disease: time for a tailored fit?

Caterina Casari
Bari International Conference BIC, Sep 2021, Venezia, Italy
Communication dans un congrès hal-04459526 v1

New Treatment Options for VWD

Caterina Casari
International Society of Thrombosis and Haemostasis ISTH, Jul 2021, Philadelphia - online, United States
Communication dans un congrès hal-04459485 v1

Vecchi e nuovi percorsi del bus molecolare: il fattore di von Willebrand

Caterina Casari
XXVI SISET, Nov 2020, Baveno - online, Italy
Communication dans un congrès hal-04459467 v1

Dégradation du facteur Willebrand et syndrome de Willebrand acquis: Utilisation des dispositifs de support mécanique

Caterina Casari
GFHT 2019, Sep 2019, Montpellier, France
Communication dans un congrès hal-04459451 v1