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Cécile Denis

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A nanobody against the VWF A3 domain detects ADAMTS13-induced proteolysis in congenital and acquired VWD

Claire Kizlik-Masson , Ivan Peyron , Stéphane Gangnard , Gaelle Le Goff , Solen Lenoir
Blood, 2023, 141 (12), pp.1457-1468. ⟨10.1182/blood.2022017569⟩
Article dans une revue hal-04363218v1

Development of a dual hybrid AAV vector for endothelial-targeted expression of von Willebrand factor

Elena Barbon , Charlotte Kawecki , Solenne Marmier , Aboud Sakkal , Fanny Collaud
Gene Therapy, 2023, 30 (3-4), pp.245-254. ⟨10.1038/s41434-020-00218-6⟩
Article dans une revue hal-04455812v1
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Efficacy of platelet-inspired hemostatic nanoparticles on bleeding in Von Willebrand disease murine models

Stéphanie Roullet , Norman Luc , Julie Rayes , Jean Solarz , Dante Disharoon
Blood, 2023, 141 (23), pp.2891-2900. ⟨10.1182/blood.2022018956⟩
Article dans une revue inserm-04066466v1

Shear Force-Induced Platelet Clearance Is a New Mechanism of Thrombocytopenia

Antoine Rauch , Annabelle Dupont , Mickael Rosa , Maximilien Desvages , Christina Le Tanno
Circulation Research, 2023, 133 (10), pp.826-841. ⟨10.1161/CIRCRESAHA.123.322752⟩
Article dans une revue hal-04455871v1
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Modèles murins en hémostase

Cécile Denis , Caterina Casari , Stéphanie Roullet
Hématologie, 2023, 29 (6), pp.338-353. ⟨10.1684/hma.2023.1827⟩
Article dans une revue hal-04457009v1
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A nanobody against the VWF A3 domain detects ADAMTS13-induced proteolysis in congenital and acquired VWD

Claire Kizlik-Masson , Ivan Peyron , Stéphane Gangnard , Gaelle Le Goff , Solen Lenoir
Blood, 2023, 141 (12), pp.1457-1468. ⟨10.1182/blood.2022017569⟩
Article dans une revue inserm-04258451v1

The Role of Platelets and von Willebrand Factor in the Procoagulant Phenotype of Inflammatory Bowel Disease

Célia Schellenberg , Jérémy Lagrange , Muhammad Usman Ahmed , Djésia Arnone , Philippe Campoli
Journal of Crohn's and Colitis, 2023, ⟨10.1093/ecco-jcc/jjad198⟩
Article dans une revue hal-04458197v1

TaSER: Combining forces to stop the clot

Cécile Denis , Peter Lenting , Denis Wahl
Journal of Thrombosis and Haemostasis, 2022, HITH, 20 (2), pp.293-295. ⟨10.1111/jth.15597⟩
Article dans une revue hal-04449115v1

A gain‐of‐function filamin A mutation in mouse platelets induces thrombus instability

Frédéric Adam , Alexandre Kauskot , Lamia Lamrani , Jean Solarz , Christelle Soukaseum
Journal of Thrombosis and Haemostasis, 2022, 20 (11), pp.2666-2678. ⟨10.1111/jth.15864⟩
Article dans une revue hal-03896872v1
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Von Willebrand factor and cancer: Another piece of the puzzle

Cécile V Denis , Stéphanie Roullet , Julien Perrin
Journal of Thrombosis and Haemostasis, 2022, 20 (10), pp.2207-2210. ⟨10.1111/jth.15810⟩
Article dans une revue inserm-03783811v1

New insights into regulation of αIIbβ3 integrin signaling by filamin A

Lamia Lamrani , Frédéric Adam , Christelle Soukaseum , Cécile Denis , Hana Raslova
Research and Practice in Thrombosis and Haemostasis, 2022, 6 (2), pp.e12672. ⟨10.1002/rth2.12672⟩
Article dans une revue hal-04449298v1

Antithrombotic potential of a single‐domain antibody enhancing the activated protein C‐cofactor activity of protein S

Josepha Sedzro , Frédéric Adam , Claire Auditeau , Elsa Bianchini , Allan de Carvalho
Journal of Thrombosis and Haemostasis, 2022, 20 (7), pp.1653-1664. ⟨10.1111/jth.15736⟩
Article dans une revue hal-04449980v1
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The VWF/LRP4/aVb3-axis represents a novel pathway regulating proliferation of human vascular smooth muscle cells

Jérémy Lagrange , Morel Worou , Jean-Baptiste Michel , Alexandre Raoul , Mélusine Didelot
Cardiovascular Research, 2022, 118 (2), pp.622-637. ⟨10.1093/cvr/cvab042⟩
Article dans une revue hal-03267669v1

New insights into regulation of αIIbβ3 integrin signaling by filamin A

Lamia Lamrani , Frédéric Adam , Christelle Soukaseum , Cécile Denis , Hana Raslova
Research and Practice in Thrombosis and Haemostasis, 2022, 6 (2), pp.e12672. ⟨10.1002/rth2.12672⟩
Article dans une revue hal-04471560v1

Antithrombotic potential of a single‐domain antibody enhancing the activated protein C‐cofactor activity of protein S

Josepha Sedzro , Frédéric Adam , Claire Auditeau , Elsa Bianchini , Allan de Carvalho
Journal of Thrombosis and Haemostasis, 2022, 20 (7), pp.1653-1664. ⟨10.1111/jth.15736⟩
Article dans une revue inserm-04455219v1
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Identification of von Willebrand factor D4 domain mutations in patients of Afro‐Caribbean descent: In vitro characterization

Marie‐daniéla Dubois , Ivan Peyron , Olivier‐nicolas Pierre-Louis , Serge Pierre-Louis , Johalène Rabout
Research and Practice in Thrombosis and Haemostasis, 2022, 6 (4), pp.e12737. ⟨10.1002/rth2.12737⟩
Article dans une revue hal-04354187v1

A compact integrated microfluidic oxygenator with high gas exchange efficiency and compatibility for long-lasting endothelialization

Julie Lachaux , Gilgueng Hwang , Nassim Arouche , Sina Naserian , Abdelmounaim Harouri
Lab on a Chip, 2021, 21 (24), pp.4791-4804. ⟨10.1039/d1lc00356a⟩
Article dans une revue hal-03853585v1

How to keep the factor VIII/von Willebrand factor complex in the circulation

Cécile Denis , Peter Lenting
Haematologica, 2021, HITH, 107 (9), pp.2011-2013. ⟨10.3324/haematol.2021.280222⟩
Article dans une revue hal-04449734v1
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Von Willebrand Disease: What does the future hold?

Cécile V Denis , Sophie Susen , Peter J. Lenting
Blood, 2021, 137 (17), pp.2299-2306. ⟨10.1182/blood.2020008501⟩
Article dans une revue hal-03267627v1
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A compact integrated microfluidic oxygenator with high gas exchange efficiency and compatibility for long-lasting endothelialization

Julie Lachaux , Gilgueng Hwang , Nassim Arouche , Sina Naserian , Abdelmounaim Harouri
Lab on a Chip, In press, ⟨10.1039/d1lc00356a⟩
Article dans une revue hal-03318488v1
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The Proteolytic Inactivation of Protein Z-Dependent Protease Inhibitor by Neutrophil Elastase Might Promote the Procoagulant Activity of Neutrophil Extracellular Traps in Sepsis

Elsa P Bianchini , Mahita Razanakolona , Julie Helms , Fouzia Zouiti , Amélie Couteau-Chardon
Thrombosis and Haemostasis, 2021, Online ahead of print. ⟨10.1055/a-1530-3980⟩
Article dans une revue inserm-03313257v1
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Development of a dual hybrid AAV vector for endothelial-targeted expression of von Willebrand factor

Elena Barbon , Charlotte Kawecki , Solenne Marmier , Aboud Sakkal , Fanny Collaud
Gene Therapy, 2021, 30 (3-4), pp.245-254. ⟨10.1038/s41434-020-00218-6⟩
Article dans une revue hal-04324328v1
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NAADP/SERCA3-dependent Ca2+ stores pathway specifically controls early autocrine ADP secretion potentiating platelet activation.

Miao Feng , Ziane Elaïb , Delphine Borgel , Cécile Denis , Frédéric Adam
Circulation Research, 2020, 127 (7), pp.e166-e183. ⟨10.1161/CIRCRESAHA.119.316090⟩
Article dans une revue inserm-02948394v1
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Camelid‐derived single‐chain antibodies in hemostasis: Mechanistic, diagnostic, and therapeutic applications

Ivan Peyron , Claire Kizlik‐masson , Marie‐daniéla Dubois , Sénadé Atsou , Stephen Ferrière
Research and Practice in Thrombosis and Haemostasis, 2020, 4 (7), pp.1087-1110. ⟨10.1002/rth2.12420⟩
Article dans une revue hal-03116405v1
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A Combination of Two Variants p. (Val510 =) and p. (Pro2145Thrfs * 5), Responsible for von Willebrand Disease Type 3 in a Caribbean Patient

Marie Daniela Dubois , Marie Daniela Dubois , Serge Pierre-Louis , Johalène Rabout , Cécile Denis
TH Open, 2020, 04 (04), pp.e318-e321. ⟨10.1055/s-0040-1718703⟩
Article dans une revue hal-03121861v1

Monoclonal gammopathy of clinical significance: in vivo demonstration of the anti-thrombotic effect of an acquired anti-thrombin antibody

Berenice Schell , Celine Desconclois , Xavier Mariette , Cecile Goujard , Peter Lenting
Haematologica, 2020, 106 (1), pp.316-319. ⟨10.3324/haematol.2019.242370⟩
Article dans une revue hal-04456957v1
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Measuring beta‐galactose exposure on platelets: Standardization and healthy reference values

Dominique Lasne , Tiffany Pascreau , Sadyo Darame , Marie‐charlotte Bourrienne , Peggy Tournoux
Research and Practice in Thrombosis and Haemostasis, 2020, 4 (5), pp.813-822. ⟨10.1002/rth2.12369⟩
Article dans une revue hal-02964593v1
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In vivo modulation of a dominant‐negative variant in mouse models of von Willebrand disease type 2A

Matteo Campioni , Paulette Legendre , Cécile Loubiere , Barbara Lunghi , Mirko Pinotti
Journal of Thrombosis and Haemostasis, 2020, Online ahead of print. ⟨10.1111/jth.15131⟩
Article dans une revue inserm-02983110v1
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Development and characterization of single‐domain antibodies neutralizing protease nexin‐1 as tools to increase thrombin generation

Charlotte Kawecki , Karen Aymonnier , Stephen Ferrière , Laurence Venisse , Véronique Arocas
Journal of Thrombosis and Haemostasis, 2020, 18, pp.2155-2168. ⟨10.1111/jth.14940⟩
Article dans une revue inserm-02934843v1

A single‐domain antibody that blocks factor VIIa activity in the absence but not presence of tissue factor

Stephen Ferrière , Charlotte Kawecki , Jean‐françois Ottavi , Cécile Denis , Alexandre Kauskot
Journal of Thrombosis and Haemostasis, 2019, 17 (12), pp.2035-2046. ⟨10.1111/jth.14615⟩
Article dans une revue hal-04455632v1

Weibel-Palade Bodies Orchestrate Pericytes During Angiogenesis

Mélissande Cossutta , Marie Darche , Gilles Carpentier , Claire Houppe , Matteo Ponzo
Arteriosclerosis, Thrombosis, and Vascular Biology, 2019, 39 (9), pp.1843-1858. ⟨10.1161/ATVBAHA.119.313021⟩
Article dans une revue hal-03095533v1

The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction

Reinhard Schneppenheim , Natalie Hellermann , Maria Brehm , Ulrike Klemm , Tobias Obser
Blood, 2019, 133 (4), pp.356-365. ⟨10.1182/blood-2018-04-843425⟩
Article dans une revue hal-04456911v1

Disrupted filamin A/αIIbβ3 interaction induces macrothrombocytopenia by increasing RhoA activity

Alessandro Donada , Nathalie Balayn , Dominika Sliwa , Larissa Lordier , Valentina Ceglia
Blood, 2019, 133 (16), pp.1778-1788. ⟨10.1182/blood-2018-07-861427⟩
Article dans une revue hal-04441275v1

Shear rate gradients promote a bi-phasic thrombus formation on weak adhesive proteins, such as fibrinogen in a VWF-dependent manner

Cécile Denis
Haematologica, 2019, 105 (10), pp.2471-2483. ⟨10.3324/haematol.2019.235754⟩
Article dans une revue hal-04456926v1
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Impact of drug consumption rooms on risk practices and access to care in people who inject drugs in France: the COSINUS prospective cohort study protocol

Marc Auriacombe , Perrine Roux , Laélia Briand Madrid , Sébastien Kirchherr , Charlotte Kervran
BMJ Open, 2019, 9 (2), pp.e023683. ⟨10.1136/bmjopen-2018-023683⟩
Article dans une revue hal-02479765v1

Endothelial-driven increase in plasma thrombin generation characterising a new hypercoagulable phenotype in acute heart failure

Batric Popovic , Faiez Zannad , Huguette Louis , Isabelle Clerc-Urmès , Cécile Lakomy
International Journal of Cardiology, 2019, 274, pp.195-201. ⟨10.1016/j.ijcard.2018.07.130⟩
Article dans une revue hal-04456909v1

Endothelial-driven increase in plasma thrombin generation characterising a new hypercoagulable phenotype in acute heart failure

Batric Popovic , Faiez Zannad , Huguette Louis , Isabelle Clerc-Urmès , Cécile Lakomy
International Journal of Cardiology, 2019, 274, pp.195-201. ⟨10.1016/j.ijcard.2018.07.130⟩
Article dans une revue hal-01944277v1

Vascular endothelial cell expression of JAK2V617F is sufficient to promote a pro-thrombotic state due to increased P-selectin expression

Alexandre Guy , Virginie Gourdou-Latyszenok , Nicolas Le Lay , Claire Peghaire , Badr Kilani
Haematologica, inPress, 104 (1), pp.70-81. ⟨10.3324/haematol.2018.195321⟩
Article dans une revue hal-02995532v1

Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor

Emma-Ruoqi Xu , Sören von Bülow , Po-Chia Chen , Peter Lenting , Katra Kolšek
Blood, 2019, 133 (4), pp.366-376. ⟨10.1182/blood-2018-04-843615⟩
Article dans une revue hal-04456916v1
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Targeting protease nexin-1, a natural anticoagulant serpin, to control bleeding and improve hemostasis in hemophilia

Karen Aymonnier , Charlotte Kawecki , Laurence Venisse , Yacine Boulaftali , Olivier D Christophe
Blood, 2019, 134 (19), pp.1632-1644. ⟨10.1182/blood.2019000281⟩
Article dans une revue inserm-03116956v1

Impact of PI3Kα (Phosphoinositide 3-Kinase Alpha) Inhibition on Hemostasis and Thrombosis

Pierre-Alexandre Laurent , Béatrice Hechler , Romain Solinhac , Ashraf Ragab , Cendrine Cabou
Arteriosclerosis, Thrombosis, and Vascular Biology, 2018, 38 (9), pp.2041-2053. ⟨10.1161/ATVBAHA.118.311410⟩
Article dans une revue hal-04457846v1

Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis

Wolfgang Bergmeier , Silvio Antoniak , Edward Conway , Cécile Denis , Lindsey George
Research and Practice in Thrombosis and Haemostasis, 2018, 2 (3), pp.407-428. ⟨10.1002/rth2.12095⟩
Article dans une revue hal-04456872v1

The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent

Julie Rayes , Soumaya Jadoui , Siân Lax , Angèle Gros , Surasak Wichaiyo
Haematologica, 2018, 103 (6), pp.e256-e258. ⟨10.3324/haematol.2017.182162⟩
Article dans une revue hal-04456875v1

Macrophage scavenger receptor SR-AI contributes to the clearance of von Willebrand factor

Nikolett Wohner , Vincent Muczynski , Amel Mohamadi , Paulette Legendre , Valérie Proulle
Haematologica, 2018, 103 (4), pp.728-737. ⟨10.3324/haematol.2017.175216⟩
Article dans une revue pasteur-03209471v1

A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation

Vincent Muczynski , Caterina Casari , François Moreau , Gabriel Ayme , Charlotte Kawecki
Blood, 2018, 132 (11), pp.1193-1197. ⟨10.1182/blood-2018-01-829523⟩
Article dans une revue pasteur-03209466v1

VWF clearance: it’s glycomplicated

Cécile Denis , Peter J. Lenting
Blood, 2018, HITH, 131 (8), pp.842-843. ⟨10.1182/blood-2018-01-824904⟩
Article dans une revue hal-04449623v1
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A factor VIII–nanobody fusion protein forming an ultrastable complex with VWF: effect on clearance and antibody formation

Vincent Muczynski , Caterina Casari , François Moreau , Gabriel Aymé , Charlotte Kawecki
Blood, 2018, 132 (11), pp.1193-1197. ⟨10.1182/blood-2018-01-829523⟩
Article dans une revue hal-04456589v1

A Novel Single-Domain Antibody Against von Willebrand Factor A1 Domain Resolves Leukocyte Recruitment and Vascular Leakage During Inflammation—Brief Report

Gabriel Ayme , Frédéric Adam , Paulette Legendre , Amine Bazaa , Valérie Proulle
Arteriosclerosis, Thrombosis, and Vascular Biology, 2017, 37 (9), pp.1736-1740. ⟨10.1161/ATVBAHA.117.309319⟩
Article dans une revue pasteur-03209478v1

Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions

Vincent Muczynski , Gabriel Aymé , Véronique Regnault , Marc Vasse , Delphine Borgel
Blood, 2017, 129 (17), pp.2443-2454. ⟨10.1182/blood-2016-06-724351⟩
Article dans une revue hal-03567147v1

Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions

Vincent Muczynski , Gabriel Ayme , Véronique Regnault , Marc Vasse , Delphine Borgel
Blood, 2017, 129 (17), pp.2443-2454. ⟨10.1182/blood-2016-06-724351⟩
Article dans une revue pasteur-03209468v1

LIM kinase/cofilin dysregulation promotes macrothrombocytopenia in severe von Willebrand disease-type 2B

Alexandre Kauskot , Sonia Poirault-Chassac , Frédéric Adam , Vincent Muczynski , Gabriel Ayme
JCI Insight, 2016, 1 (16), pp.e88643. ⟨10.1172/jci.insight.88643⟩
Article dans une revue pasteur-03209475v1
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Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity

Marion Pepin , Soraya Mezouar , Julie Pegon , Vincent Muczynski , Frédéric Adam
Scientific Reports, 2016, 6 (1), pp.37953. ⟨10.1038/srep37953⟩
Article dans une revue hal-01455400v1
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von Willebrand factor: at the crossroads of bleeding and thrombosis.

Cécile Denis , Peter J. Lenting
International Journal of Hematology, 2012, 95 (4), pp.353-61. ⟨10.1007/s12185-012-1041-x⟩
Article dans une revue inserm-00689902v1

Effectiveness of therapeutic communities: a systematic review

Marion Malivert , Mélina Fatseas , Cécile Denis , Emmanuel Langlois , Marc Auriacombe
European Addiction Research, 2012, 18 (1), pp.1-11. ⟨10.1159/000331007⟩
Article dans une revue halshs-00646645v1

Un modèle français de Communauté Thérapeutique ? Les communautés thérapeutiques expérimentales : Consensus des professionnels

Cécile Denis , Emmanuel Langlois , Mélina Fatseas , Marc Auriacombe
Psychotropes, 2011, Les communautés thérapeutiques, 17 (3-4), pp.81-97. ⟨10.3917/psyt.173.0085⟩
Article dans une revue halshs-00681281v1
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Epilepsy in Dcx knockout mice associated with discrete lamination defects and enhanced excitability in the hippocampus.

Marika Nosten-Bertrand , Caroline Kappeler , Céline Dinocourt , Cécile Denis , Johanne Germain
PLoS ONE, 2008, 3 (6), pp.e2473. ⟨10.1371/journal.pone.0002473⟩
Article dans une revue inserm-00378410v1
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Parallel Loss of Hippocampal LTD and Cognitive Flexibility in a Genetic Model of Hyperdopaminergia.

Elise Morice , Jean-Marie Billard , Cécile Denis , Flavie Mathieu , Catalina Betancur
Neuropsychopharmacology, 2007, 32 (10), pp.2108-16. ⟨10.1038/sj.npp.1301354⟩
Article dans une revue inserm-00166900v1

MICAL1 links actin dynamics to shear-dependent adhesive and thrombotic function of platelets

Jean Solarz , Christelle Soukaseum , Christelle Repérant , Cécile Denis , Frédéric Adam
Congrès Français d’Hémostase, May 2023, Saint-Malo, France
Poster de conférence hal-04455404v1

Effect of allele-selective silencing of von Willebrand factor in mice on experimental bleeding and thrombosis models

Jongejan Yvonne , Linthorst Noa , Schrader E , Laan Snj , R.J. Dirven
Congress of the International Society on Thrombosis and Haemostasis, Jun 2023, Montreal, Canada. Res. Pract. Thromb. Haemost., 7 (Suppl. 2), pp.Abstract PB 1431, 2023
Poster de conférence hal-04501158v1

Le récepteur PAR4 initie la voie SERCA3/NAADP qui potentialise l'activation des plaquettes en réponse à la thrombine.

Miao Feng , Frédéric Adam , Alexandre Kauskot , Cécile Denis , Marijke Bryckaert
Congrès Francais d'Hémostase, May 2023, Saint malo, France
Poster de conférence hal-04455436v1

MAGT1 DEFICIENCY CAUSES A PROMINENT PLATELETS DYSFUNCTION THROUGH IMPAIRMENT OF MEMBRANE GLYCOPROTEINS N-GLYCOSYLATION

Alexandre Kauskot , Coralie Mallebranche , Jean Solarz , Miao Feng , Toscane Viellard
20th Biennial Meeting of the European Society for Immunodeficiencies (ESID), Oct 2022, Gothenburg, Sweden. Abstract 801
Poster de conférence hal-04455514v1

Resistance to Fibrinolysis in Critically Ill Patients with COVID-19 Can Be Overcome by N-acetylcysteine in vitro

Dorothée Faille , Marie Charlotte Bourrienne , Gay J , Benoit Ho Tin Noé , Stephane Loyau
Hybrid Congress of the International Society on Thrombosis and Haemostasis, Jul 2021, Philadelphia (Pennsylvania), United States. Res. Pract. Thromb. Haemost, 5 (Suppl. 1), pp.Abstract LPB0104, 2021
Poster de conférence hal-04501103v1

NAADP/SERCA3-Dependent Ca2+ Stores Pathway Specifically Controls Early Autocrine ADP Secretion Potentiating Platelet Activation

Miao Feng , Ziane Elaib , Delphine Borgel , Cécile Denis , Frederic Adam
Virtual Congress of the International Society on Thrombosis and Haemostasis, Jul 2020, Milan (Virtual), Italy. Res. Pract. Thromb. Haemost, 4 (Suppl. 1), pp.Abstract PB1745, 2020
Poster de conférence hal-04501065v1

Prothrombotic gain-of-functin variants of von Willebrand factor.

V. Huck , Alexander Tischer , Mess C , Tobias Obser , Köning G
Virtual Congress of the International Society on Thrombosis and Haemostasis, Jul 2020, Milan (Virtual), Italy. Res. Pract. Thromb. Haemost, 4 (Suppl. 1), pp.Abstract PB1584, 2020
Poster de conférence hal-04501054v1

Standardization of a Flow Cytometry Platelet Sialylation Assay, and reference Values forBeta-Galactose Exposure in Healthy Subjects

Dominique Lasne , Tiffany Pascreau , Sadyo Darame , Marie-Charlotte Bourrienne , Aurélien Philippe
ISTH, 2020, Jul 2020, Milan (Italie), Italy. PB0441
Poster de conférence hal-04454870v1

Von Willebrand Factor Induces Vascular Smooth Muscle Cell Proliferation And Migration Through Low Density Lipoprotein-Related Receptor Protein 4 And αvβ3 Integrin

Jeremy Lagrange , Jean-Baptiste Michel , Alexandre Raoul , Peter J. Lenting , Patrick Lacolley
American Heart Association's Vascular Discovery: From Genes to Medicine 2020 Scientific Sessions, May 2020, Virtual meeting (Live and on-demand), France. Arteriosclerosis, Thrombosis, and Vascular Biology, 40 (Suppl1), pp.Abstract 304, 2020
Poster de conférence hal-04499901v1

Transplacental delivery of maternal factor VIII for induction of immune tolerance to therapeutic factor VIII

Angelina Mimoun , Melissa Bou Jaoudeh , Ivan Peyron , Daventure V , Sandrine Delignat
Virtual Congress of the International Society on Thrombosis and Haemostasis, Jul 2020, Milan (Virtual), Italy. Res. Pract. Thromb. Haemost, 4 (Suppl. 1), pp.Abstract PB0177, 2020
Poster de conférence hal-04501045v1

The VWF-GPIb interaction mediates thrombo-inflammation in experimental stroke via recruitment of monocytes, neutrophils and T-cells to the brain

Frederik Denorme , Kimberly Martinod , Vandebulcke A , Cécile Denis , Peter J. Lenting
XXVIIth Congress of the International Society on Thrombosis and Haemostasis, Jul 2019, Melbourne (AUS), Australia. Res. Pract. Thromb. Haemost., 3 (Suppl. 1), pp.Abstract PB1002, 2019
Poster de conférence hal-04499886v1

Relevance of platelet desialylation and thrombocytopenia in type 2B von Willebrand disease

Annabelle Dupont , Christelle Soukaseum , Mathilde Cheptou , Frédéric Adam , Thomas Nipoti
GRC, Cell biology of megakaryocytes and platelets, 2019, Mar 2019, Galveston - Texas, United States
Poster de conférence hal-04455289v1

Phosphoinositide 3-kinase  (PI3K) triggers PI3K activation at low levels of GPVI stimulation and controls platelet arrest on von Willebrand factor ar arterial shear.

Laurent P-A , Beatrice Hechler , Solinhac R , Cabou C , Anquetil T
XXVIIth Congress of the International Society on Thrombosis and Haemostasis, Jul 2019, Melbourne (AUS), Australia. Res. Pract. Thromb. Haemost, 3 (Suppl. 1), pp.Abstract PB463, 2019
Poster de conférence hal-04499868v1

Development of single domain antibodies targeting protease nexin-1 as a strategy for hemophilia treatment

Charlotte Kawecki , Karen Aymonnier , Laurence Venisse , Véronique Arocas , Olivier Christophe
XXVIIth Congress of the International Society on Thrombosis and Haemostasis, Jul 2019, Melbourne (AUS), Australia. Res. Pract. Thromb. Haemost, 3 (Suppl. 1), pp.Abstract PB0316, 2019
Poster de conférence hal-04499858v1

Modulation of the platelet count by Romiplostim and inhibitors of LIM kinase in genetically-engineered von Willebrand disease type 2B mice: in vivo evaluation of haemostatic efficiency.

Mathilde Cheptou , Frédéric Adam , Olivier Christophe , Peter Lenting , Cécile Denis
ECTH, 2018, Oct 2018, Marseille, France
Poster de conférence hal-04455308v1

L'angiopoïétine-2 se lie à de multiples sites interactifs au sein du facteur von Willebrand

Alexis Texier , Peter J. Lenting , Cécile Denis , Stéphanie Roullet , Olivier Christophe
44ème congrès de la Société Française d'Hématologie, Société Française d'Hématologie, Mar 2024, Paris, France. pp.P327, Abstract 18-03
Communication dans un congrès inserm-04541054v1

Llama-derived single-domain antibodies blocking tissue factor pathway inhibitor and increasing thrombin generation in FVIII- and FX-deficient plasma

Francois Saller , Ivan Peyron , Andrea Ruty , Saenjamsai P , Claire Auditeau
European Congress on Thrombosis and Haemostasis, Sep 2023, Valence (Espagne), Spain
Communication dans un congrès hal-04501177v1

MICAL1, un nouvel acteur moléculaire impliqué dans la stabilisation du thrombus

Jean Solarz , Christelle Soukaseum , Cécile Denis , Frédéric Adam , Alexandre Kauskot
Congrès Société Française d’Hématologie 2023, Mar 2023, Paris, France
Communication dans un congrès hal-04455383v1

A single-domain antibody enhancing protein S activity reduces vaso-occlusion in two murine models of sickle cell disease

Claire Auditeau , Thiago Maciel , Josepha Sedzro , Camille Roussel , Aurélie Fricot-Monsinjon
European Congress on Thrombosis and Haemostasis, Sep 2023, Valence (Espagne), Spain
Communication dans un congrès hal-04501174v1

Allele-selective inhibition of mutant von Willebrand factor with small interfering RNAs to ameliorate a von Willebrand disease type 2B phenotype in vivo in mice

Linthorst Noa , Jongejan Yvonne , Bierings Ruben , Dahlman Je , Cécile Denis
Congress of the International Society on Thrombosis and Haemostasis, International Society on Thrombosis and Haemostasis, Jun 2023, Montreal (Canada), Canada. pp.100553. Abstract OC 08.5
Communication dans un congrès hal-04501151v1

Effects of platelet-inspired haemostatic nanoparticles on bleeding in von Willebrand disease murine models

Stéphanie Roullet , Norman Luc , Julie Rayes , Frédéric Adam , Andrew J Dito
ISTH 2022 Congress, International Society of Thrombosis and Hemostasis, 2022, Londres, United Kingdom
Communication dans un congrès hal-04455066v1

MICAL1, un nouvel acteur des forces contractiles dans le thrombus

Jean Solarz , Christelle Soukaseum , Frédéric Adam , Cécile Denis , Alexandre Kauskot
Club Français de Plaquettes et des Mégacaryocytes, May 2022, Bordeaux, France
Communication dans un congrès hal-04455372v1

Antithrombotic Potential of a Single-domain Antibody Enhancing the Anticoagulant Activity of Protein S

Josepha Sedzro , Frédéric Adam , Allan De Carvalho , Elsa P Bianchini , Ivan Peyron
Hybrid Congress of the International Society on Thrombosis and Haemostasis, International Society on Thrombosis and Haemostasis, Jul 2021, Philadelphia (Pennsylvania), United States. pp.Abstract OC 60.2
Communication dans un congrès hal-04501112v1

Transplacental Delivery of Maternal FVIII for Induction of FVIII-specific Immune Tolerance

Angelina Mimoun , Melissa Bou Jaoudeh , Ivan Peyron , Victoria Daventure , Sandrine Delignat
Hybrid Congress of the International Society on Thrombosis and Haemostasis, International Society on Thrombosis and Haemostasis, Jul 2021, Philadelphia (Pennsylvania), United States. pp.Abstract OC 14.1
Communication dans un congrès hal-04501088v1

Caractérisation d’une nanobody qui potentialize l’activité cofacteur de la protéine C active de la protéine S

Sedzro Jc , Francois Saller , Frédéric Adam , De Carvalho , Sophie Gandrille
40ème congrès de la Société Française d’Hématologie, Société Française d’Hématologie, Sep 2020, Paris, France. pp.Page 39, Abstract 04-01
Communication dans un congrès hal-04501074v1

p.(Pro2145Thrfs*5) et p.(Cys2216Phefs*9), deux Nouvelles mutations identifiées dans le domaine D4 du facteur von Willebrand chez des patientes d’origine afro-caribéenne

Marie Daniela Dubois , Serge Pierre-Louis , Johalène Rabout , Cécile Denis , Olivier Christophe
40ème congrès de la Société Française d’Hématologie, Société Française d’Hématologie, Sep 2020, Paris, France. p 50, Abstract 05-07
Communication dans un congrès hal-04501081v1

L'ADP sécrétée par la voie de signalisation calcique plaquettaire NAADP/SERCA3 active spécifiquement le récepteur purinergique P2Y12 et pas P2Y1

Miao Feng , Cécile Denis , Regis Bobe , Jean‐philippe Rosa
8ème rencontre Club français des plaquettes et des mégacayocytes, Nov 2020, plateforme zoom, France
Communication dans un congrès hal-04455261v1

Diagnostic moléculaire de la maladie de von Willebrand de type 1C avec trouble de la clairance et mutation de la région propeptide

Dubois Md , Pierre-Louis S , Bourdin C , Cécile Denis , Johalène Rabout
39th Congress of the Société Française d’Hématologie, Société Française d’Hématologie, Mar 2019, Paris, France. pp.142
Communication dans un congrès hal-04498426v1

A inducible mouse model of Factor X deficiency to test novel FX therapeutics

Sebastien Verhenne , Loubiere C , Cécile Denis , Peter J. Lenting , Olivier Christophe
XXVIIth Congress of the International Society on Thrombosis and Haemostasis, International Society on Thrombosis and Haemostasis, Jul 2019, Melbourne (AUS), Australia. pp.Abstract OC 28.4
Communication dans un congrès hal-04499851v1

Targeting Protease Nexin-1, a natural anticoagulant to control bleeding in hemophilia A

Karen Aymonnier , Charlotte Kawecki , Laurence Venisse , Emmanuelle de Raucourt , Olivier Christophe
XXVIIth Congress of the International Society on Thrombosis and Haemostasis, International Society on Thrombosis and Haemostasis, Jul 2019, Melbourne (AUS), Australia. pp.Abstract OC 75.3
Communication dans un congrès hal-04498448v1

Développement d’un modèle de souris avec un déficit inductible en facteur X

Sebastien Verhenne , Loubière Cécile , Elena Barbon , F Mingozzi , Cécile Denis
39th Congress of the Société Française d’Hématologie, Société Française d’Hématologie, Mar 2019, Paris, France. pp.Abstract 12-29
Communication dans un congrès hal-04498403v1

La rupture de l'interaction entre la filamine A et le complexe aIIbb3 conduit à l'activation de la voie RhoA entraînant une macrothrombocytopénie

Alessandro Donada , Balayn N , Sliwa D , Larissa L , Ceglia V
39th Congress of the Société Française d’Hématologie, Société Française d’Hématologie, Mar 2019, Paris, France. pp.142
Communication dans un congrès hal-04498415v1

Von Willebrand factor induces human vascular smooth muscle cells proliferation through low density lipoprotein-related receptor 4 and alphavbeta3 integrin

Morel Worou , Melusine Didelot , Vincent Muczynski , Raoul A , Paulette Legendre
XXVIIth Congress of the International Society on Thrombosis and Haemostasis, International Society on Thrombosis and Haemostasis, Jul 2019, Melbourne (AUS), Australia
Communication dans un congrès hal-04498513v1

La Protéase Nexine-1, un inhibiteur physiologique de la thrombine, cible potentielle dans le traitement de l’hémophilie.

Karen Aymonnier , Charlotte Kawecki , Laurence Venisse , Emmanuelle de Raucourt , Olivier Christophe
38th Congress of the Société Française d’Hématologie, Société Française d’Hématologie, Mar 2018, PARIS, France. p 133, Abstract 12-59
Communication dans un congrès hal-04457483v1

The potential use of nanobodies delivered via AAV vectors in the treatment of hemophilia

Elena Barbon , Gabriel Ayme , Amel Mohamadi , Cécile Denis , Olivier Christophe
21st Annual Meeting of the American Society of Gene and Cell Therapy, American Society of Gene and Cell Therapy, May 2018, CHICAGO, United States
Communication dans un congrès hal-04457494v1

Maladie de Willebrande type 2B et thrombopénies : Impact de la désialylation des plaquettes.

Annabelle Dupont , Christelle Soukaseum , Frédéric Adam , Paulette Legendre , Valérie Proulle
38th Congress of the Société Française d’Hématologie, Société Française d’Hématologie, Mar 2018, Paris, France. pp.Page 143, Abstract 12-88
Communication dans un congrès hal-04457466v1

Targeting Protease Nexin-1, a natural anticoagulant to control bleeding in hemophilia A

Karen Aymonnier , Charlotte Kawecki , Laurence Venisse , Emmanuelle de Raucourt , Olivier Christophe
2nd European Congress on Thrombosis and Haemostasis, Oct 2018, Marseille, France
Communication dans un congrès hal-04457505v1

Thrombin-mediated cleavage of membrane endoglin: Implications in endothelial dysfunction

Divina El Hamaoui , Aurore Marchelli , Sophie Gandrille , Alain Stepanian , Franck Lebrin
17th Annual Congress of the European Association for Haemophilia and Allied Disorders 2024, Haemophilia, 30 (S1), pp.34-188, 2024, ⟨10.1111/hae.14919⟩
Proceedings/Recueil des communications hal-04460082v1

Thrombin-mediated activation of factor VIII is insufficient to produce all necessary cofactor activity in vivo

Charlotte Kawecki , Ivan Peyron , Amine Bazaa , Vincent Muczynski , Stephen Ferrière
Congress of the International Society of Thrombosis and Haemostasis, Research and Practice in Thrombosis and Haemostasis, 3, pp.1-891, 2019, ⟨10.1002/rth2.12229⟩
Proceedings/Recueil des communications hal-04461945v1

Évaluation des communautés thérapeutiques en France. Quelle mise en oeuvre, quels résultats ? Etude prospective sur deux ans dans quatre communautés thérapeutiques

Cécile Denis , Mélina Fatseas , Emmanuel Langlois , Antoine Vérétout , Marc Auriacombe
[Rapport de recherche] Observatoire français des drogues et toxicomanies (OFDT); Mission interministérielle de lutte contre la drogue et la toxicomanie (MILDT); Direction générale de la santé (DGS). 2011
Rapport halshs-00594027v1