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Cancer immunotherapy in elderly patients: the concept of immune senescence challenged by clinical experience

Mathilde Guégan , Malvina Bichon , Nathalie Chaput , Roch Houot , Jean Lemoine
European Journal of Cancer, 2024, 214, pp.115145-115145. ⟨10.1016/j.ejca.2024.115145⟩
Article dans une revue hal-04891566 v1

Metabolic tumor volume assessed by 18F FDG - PET CT scan as a predictive biomarker for immune checkpoint blockers in advanced NSCLC and its biological correlates.

Filippo Dall'Olio , Wael Zrafi , Veronique Roelants , Valentina Ambrosini , Aloyse Fourquet et al.
Clinical Cancer Research, 2024, ⟨10.1158/1078-0432.CCR-24-1993⟩
Article dans une revue (article de synthèse) hal-04806943 v1
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B cells and the coordination of immune checkpoint inhibitor response in patients with solid tumors

Ronan Flippot , Marcus Teixeira , Macarena Rey-Cardenas , Lucia Carril-Ajuria , Larissa Rainho et al.
Journal for Immunotherapy of Cancer, 2024, 12 (4), pp.e008636. ⟨10.1136/jitc-2023-008636⟩
Article dans une revue inserm-04685443 v1

Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8 + T cells in patients with advanced NSCLC

Marie Naigeon , Matthieu Roulleaux Dugage , François-Xavier Danlos , Lisa Boselli , Jean-Mehdi Jouniaux et al.
Science Advances , 2023, 9 (45), ⟨10.1126/sciadv.adh0708⟩
Article dans une revue hal-04719261 v1
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Genomic Instability and Pro-Tumoral Inflammation are associated with Primary Resistance to Anti-PD1 + Anti-Angiogenesis in Malignant Pleural Mesothelioma

Francois-Xavier Danlos , Matthieu Texier , Bastien Job , Severine Mouraud , Lydie Cassard et al.
Cancer Discovery, 2023, 13 (4), pp.858-879. ⟨10.1158/2159-8290.CD-22-0886⟩
Article dans une revue hal-03972355 v1

Overcoming resistance to αPD-1 of MMR-deficient tumors with high tumor-induced neutrophils levels by combination of αCTLA-4 and αPD-1 blockers

Laetitia Nebot-Bral , Antoine Hollebecque , Andrey Yurchenko , Louise de Forceville , Mathieu Danjou et al.
Journal for Immunotherapy of Cancer, 2022, 10 (7), pp.e005059. ⟨10.1136/jitc-2022-005059⟩
Article dans une revue hal-03852523 v1
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Overcoming resistance to αPD-1 of MMR-deficient tumors with high tumor-induced neutrophils levels by combination of αCTLA-4 and αPD-1 blockers

Laetitia Nebot-Bral , Antoine Hollebecque , Andrey A Yurchenko , Louise de Forceville , Mathieu Danjou et al.
Journal for Immunotherapy of Cancer, 2022, 10 (7), pp.e005059. ⟨10.1136/jitc-2022-005059⟩
Article dans une revue hal-03853375 v1

Plasma CD27, a Surrogate of the Intratumoral CD27–CD70 Interaction, Correlates with Immunotherapy Resistance in Renal Cell Carcinoma

Nadine Benhamouda , Ikuan Sam , Nicolas Epaillard , Alain Gey , Letuan Phan et al.
Clinical Cancer Research, 2022, 28 (22), pp.4983 - 4994. ⟨10.1158/1078-0432.ccr-22-0905⟩
Article dans une revue pasteur-04142515 v1
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Association of AXL and PD-L1 Expression with Clinical Outcomes in Patients with Advanced Renal Cell Carcinoma Treated with PD-1 Blockade

Stéphane Terry , Cécile Dalban , Nathalie Rioux-Leclercq , Julien Adam , Maxime Meylan et al.
Clinical Cancer Research, 2021, 27 (24), pp.6749-60. ⟨10.1158/1078-0432.CCR-21-0972⟩
Article dans une revue hal-03477307 v1
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Cancer and immunotherapy: a role for microbiota composition

Fiona Pham , Fabien Moinard-Butot , Clélia Coutzac , Nathalie Chaput
European Journal of Cancer, 2021, 155, pp.145-154. ⟨10.1016/j.ejca.2021.06.051⟩
Article dans une revue hal-04099088 v1
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Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer

Clélia Coutzac , Jean Mehdi Jouniaux , Angelo Paci , Julien Schmidt , Domenico Mallardo et al.
Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-16079-x⟩
Article dans une revue hal-03109210 v1
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Interleukin‐7/Interferon axis drives T‐cell and salivary gland epithelial cell interactions in Sjögren’s syndrome

Elodie Rivière , Juliette Pascaud , Alexandre Virone , Anastasia Dupré , Bineta Ly et al.
Arthritis & rheumatology, 2020, 73 (4), pp.631-640. ⟨10.1002/art.41558⟩
Article dans une revue pasteur-03036519 v1

Why is immunotherapy effective (or not) in patients with MSI/MMRD tumors?

Laetitia Nebot-Bral , Clélia Coutzac , Patricia L Kannouche , Nathalie Chaput
Bulletin du Cancer, 2019, 106 (2), pp.105-113. ⟨10.1016/j.bulcan.2018.08.007⟩
Article dans une revue hal-02425478 v1
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IL-15 superagonist RLI has potent immunostimulatory properties on NK cells: implications for antimetastatic treatment

Mélanie Desbois , Coralie Béal , Mélinda Charrier , Benjamin Besse , Guillaume Meurice et al.
Journal for Immunotherapy of Cancer, 2019, 8 (1), pp.e000632. ⟨10.1136/jitc-2020-000632⟩
Article dans une revue inserm-03498336 v1
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Estimating causal effects of time-dependent exposures on a binary endpoint in a high-dimensional setting

Vahé Asvatourian , Clélia Coutzac , Nathalie Chaput , Caroline Robert , Stefan Michiels et al.
BMC Medical Research Methodology, 2018, 18 (1), pp.67. ⟨10.1186/s12874-018-0527-5⟩
Article dans une revue inserm-02310420 v1

Enterocolitis due to immune checkpoint inhibitors: a systematic review

Emilie Soularue , Patricia Lepage , Jean-Fréderic Colombel , Clelia Coutzac , David Faleck et al.
Gut, 2018, 67 (11), pp.2056-2067. ⟨10.1136/gutjnl-2018-316948⟩
Article dans une revue hal-02626171 v1
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Deep phenotyping of immune cell populations by optimized and standardized flow cytometry analyses

Fabien Pitoiset , Lydie Cassard , Karim El Soufi , Lisa Boselli , Jonathan Grivel et al.
Cytometry Part A, 2018, 93 (8), pp.793-802. ⟨10.1002/cyto.a.23570⟩
Article dans une revue hal-01955310 v1

Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab

Nathalie Chaput , Patricia Lepage , Clelia Coutzac , E Soularue , Karine Le Roux et al.
Annals of Oncology, 2017, ⟨10.1093/annonc/mdx108⟩
Article dans une revue hal-01604339 v1

Colon Immune-Related Adverse Events: Anti-CTLA-4 and Anti-PD-1 Blockade Induce Distinct Immunopathological Entities

Clelia Coutzac , Julien Adam , Emilie Soularue , Michael Collins , Antoine Racine et al.
Journal of Crohn's and Colitis, 2017, 11 (10), pp.1238-1246. ⟨10.1093/ecco-jcc/jjx081⟩
Article dans une revue hal-02625648 v1

Inflammatory bowel disease and cancer response due to anti-CTLA-4: is it in the flora?

Franck Carbonnel , Emilie Soularue , Clélia Coutzac , Nathalie Chaput , Christine Mateus et al.
Seminars in Immunopathology, 2017, 39 (3), pp.327-331. ⟨10.1007/s00281-016-0613-x⟩
Article dans une revue (article de synthèse) hal-01607061 v1

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

Benjamin Besse , Melinda Charrier , Valerie Lapierre , Eric Dansin , Olivier Lantz et al.
OncoImmunology, 2016, 5 (4), ⟨10.1080/2162402X.2015.1071008⟩
Article dans une revue hal-01440237 v1
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IL-15 Trans-Signaling with the Superagonist RLI Promotes Effector/Memory CD8+ T Cell Responses and Enhances Antitumor Activity of PD-1 Antagonists

Mélanie Desbois , Pauline Le Vu , Clélia Coutzac , Elie Marcheteau , Coralie Béal et al.
Journal of Immunology, 2016, 197 (1), pp.168 - 178. ⟨10.4049/jimmunol.1600019⟩
Article dans une revue inserm-01823361 v1

Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25

Dalil Hannani , Marie Vétizou , David Enot , Sylvie Rusakiewicz , Nathalie Chaput et al.
Cell Research, 2015, 25 (2), pp.208-224. ⟨10.1038/cr.2015.3⟩
Article dans une revue hal-02047405 v1
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Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Marie Vétizou , Jonathan M. Pitt , Romain Daillere , Patricia Lepage , Nadine Waldschmitt et al.
Science, 2015, 350 (6264), pp.1079-1084. ⟨10.1126/science.aad1329⟩
Article dans une revue hal-02639698 v1
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Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Ana I Romero , Nathalie Chaput , Vichnou Poirier-Colame , Sylvie Rusakiewicz , Nicolas Jacquelot et al.
Cancer Research, 2014, 74 (1), pp.68. ⟨10.1158/0008-5472.CAN-13-1186⟩
Article dans une revue inserm-02442721 v1

Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors.

Nicolas F Delahaye , Sylvie Rusakiewicz , Isabelle Martins , Cédric Ménard , Stephan Roux et al.
Nature Medicine, 2011, 17 (6), pp.700-7. ⟨10.1038/nm.2366⟩
Article dans une revue hal-00665651 v1
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Contribution of IL-17-producing {gamma}{delta} T cells to the efficacy of anticancer chemotherapy.

Yuting Ma , Laetitia Aymeric , Clara Locher , Stephen R Mattarollo , Nicolas F Delahaye et al.
Journal of Experimental Medicine, 2011, 208 (3), pp.491-503. ⟨10.1084/jem.20100269⟩
Article dans une revue pasteur-00576679 v1

Updated Technology to Produce Highly Immunogenic Dendritic Cell-derived Exosomes of Clinical Grade

Sophie Viaud , Stéphanie Ploix , Valérie Lapierre , Clotilde Théry , Pierre-Henri Commere et al.
Journal of Immunotherapy, 2011, 34 (1), pp.65-75. ⟨10.1097/CJI.0b013e3181fe535b⟩
Article dans une revue hal-03272286 v1

Opposing effects of toll-like receptor (TLR3) signaling in tumors can be therapeutically uncoupled to optimize the anticancer efficacy of TLR3 ligands.

Rosa Conforti , Yuting Ma , Yannis Morel , Carine Paturel , Magali Terme et al.
Cancer Research, 2010, 70 (2), pp.490-500. ⟨10.1158/0008-5472.CAN-09-1890⟩
Article dans une revue hal-00591518 v1
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Dendritic Cell-Derived Exosomes Promote Natural Killer Cell Activation and Proliferation: A Role for NKG2D Ligands and IL-15Rα

Sophie Viaud , Magali Terme , Caroline Flament , Julien Taieb , Fabrice André et al.
PLoS ONE, 2009, 4 (3), pp.e4942. ⟨10.1371/journal.pone.0004942⟩
Article dans une revue pasteur-03360096 v1

Massive expansion of regulatory T-cells following interleukin 2 treatment during a phase I-II dendritic cell-based immunotherapy of metastatic renal cancer.

François M Lemoine , Mustapha Cherai , Camille Giverne , Dalia Dimitri , Michelle Rosenzwajg et al.
International Journal of Oncology, 2009, 35 (3), pp.569-81
Article dans une revue hal-00420217 v1

Natural killer cell IFN-gamma levels predict long-term survival with imatinib mesylate therapy in gastrointestinal stromal tumor-bearing patients.

Cédric Ménard , Jean-Yves Blay , Christophe Borg , Stefan Michiels , François Ghiringhelli et al.
Cancer Research, 2009, 69 (8), pp.3563-9. ⟨10.1158/0008-5472.CAN-08-3807⟩
Article dans une revue inserm-00484764 v1

The dendritic cell-like functions of IFN-producing killer dendritic cells reside in the CD11b+ subset and are licensed by tumor cells.

Magali Terme , Grégoire Mignot , Evelyn Ullrich , Mathieu Bonmort , Véronique Minard-Colin et al.
Cancer Research, 2009, 69 (16), pp.6590-7. ⟨10.1158/0008-5472.CAN-08-4473⟩
Article dans une revue inserm-00451699 v1

The critical role of IL-15 in the antitumor effects mediated by the combination therapy imatinib and IL-2.

Grégoire Mignot , Evelyn Ullrich , Mathieu Bonmort , Cédric Ménard , Lionel Apetoh et al.
Journal of Immunology, 2008, 180 (10), pp.6477-83
Article dans une revue hal-00364426 v1

Trans-presentation of IL-15 dictates IFN-producing killer dendritic cells effector functions.

Evelyn Ullrich , Mathieu Bonmort , Gregoire Mignot , Benedikt Jacobs , Daniela Bosisio et al.
Journal of Immunology, 2008, 180 (12), pp.7887-97
Article dans une revue hal-00363902 v1

Dendritic cells and innate defense against tumor cells.

Evelyn Ullrich , Cédric Ménard , Caroline Flament , Magali Terme , Grégoire Mignot et al.
Cytokine & Growth Factor Reviews, 2008, 19 (1), pp.79-92. ⟨10.1016/j.cytogfr.2007.10.009⟩
Article dans une revue istex inserm-00318515 v1

Killer dendritic cells: IKDC and the others.

Mathieu Bonmort , Marc Dalod , Grégoire Mignot , Evelyn Ullrich , Nathalie Chaput et al.
Current Opinion in Immunology, 2008, epub ahead of print. ⟨10.1016/j.coi.2008.04.006⟩
Article dans une revue istex hal-00294468 v1

Therapy-induced tumor immunosurveillance involves IFN-producing killer dendritic cells.

Evelyn Ullrich , Mathieu Bonmort , Grégoire Mignot , Nathalie Chaput , Julien Taieb et al.
Cancer Research, 2007, 67 (3), pp.851-3. ⟨10.1158/0008-5472.CAN-06-3766⟩
Article dans une revue inserm-00451703 v1

Chemoimmunotherapy of Tumors: Cyclophosphamide Synergizes with Exosome Based Vaccines

Julien Taieb , Nathalie Chaput , Noël Schartz , Stéphan Roux , Sophie Novault et al.
Journal of Immunology, 2006, 176 (5), pp.2722-2729. ⟨10.4049/jimmunol.176.5.2722⟩
Article dans une revue pasteur-03360098 v1
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CD4<b>+</b>CD25<b>+</b> regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner

François Ghiringhelli , Cédric Ménard , Magali Terme , Caroline Flament , Julien Taieb et al.
Journal of Experimental Medicine, 2005, 202 (8), pp.1075 - 1085. ⟨10.1084/jem.20051511⟩
Article dans une revue inserm-04685415 v1
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Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

Noelia Casares , Marie O Pequignot , Antoine Tesniere , François Ghiringhelli , Stéphan Roux et al.
Journal of Experimental Medicine, 2005, 202 (12), pp.1691 - 1701. ⟨10.1084/jem.20050915⟩
Article dans une revue inserm-04685411 v1

The potential of exosomes in immunotherapy of cancer

Nathalie Chaput , Julien Taïeb , Noël Schartz , Caroline Flament , Sophie Novault et al.
Blood Cells, Molecules and Diseases, 2005, 35 (2), pp.111-115. ⟨10.1016/j.bcmd.2005.05.009⟩
Article dans une revue istex pasteur-03360103 v1
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Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial.

Bernard Escudier , Thierry Dorval , Nathalie Chaput , Fabrice André , Marie-Pierre Caby et al.
J Transl Med, 2005, 3, pp.10. ⟨10.1186/1479-5876-3-10⟩
Article dans une revue inserm-00092539 v1

Immune response against dying tumor cells.

Laurence Zitvogel , Noelia Casares , Marie O Péquignot , Nathalie Chaput , Matthew L Albert et al.
Advances in immunology, 2004, pp.131-79. ⟨10.1016/S0065-2776(04)84004-5⟩
Article dans une revue pasteur-01402386 v1