Charles-Adrien RICHARD

62
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Publications

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Regulation of respiratory syncytial virus nucleoprotein oligomerization by phosphorylation

Vincent Basse , Yao Wang , Carine Rodrigues-Machado , Céline Henry , Charles-Adrien Richard et al.
Journal of Biological Chemistry, 2025, 301 (3), pp.108256. ⟨10.1016/j.jbc.2025.108256⟩
Article dans une revue hal-04952022 v1
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Intranasal spike and nucleoprotein fusion protein-based vaccine provides cross-protection and reduced transmission against SARS-CoV-2 variants

Zineb Lakhrif , Agathe Poupée-Beaugé , Fanny Boursin , Céline Ducournau , Louis Lantier et al.
NPJ vaccines, 2025, 10 (1), pp.75. ⟨10.1038/s41541-025-01123-y⟩
Article dans une revue hal-05046705 v1
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Selective targeting and clustering of phosphatidylserine lipids by RSV M protein is critical for virus particle production

Jitendriya Swain , Maxime Bierre , Laura Veyrié , Charles-Adrien Richard , Jean-François Eléouët et al.
Journal of Biological Chemistry, 2023, 299 (11), pp.105323. ⟨10.1016/j.jbc.2023.105323⟩
Article dans une revue hal-04283163 v1
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Hardening of Respiratory Syncytial Virus Inclusion Bodies by Cyclopamine Proceeds through Perturbation of the Interactions of the M2-1 Protein with RNA and the P Protein

Cédric Diot , Charles-Adrien Richard , Jennifer Risso-Ballester , Davy Martin , Jenna Fix et al.
International Journal of Molecular Sciences, 2023, 24 (18), pp.13862. ⟨10.3390/ijms241813862⟩
Article dans une revue hal-04239191 v1
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Investigation of the Fuzzy Complex between RSV Nucleoprotein and Phosphoprotein to Optimize an Inhibition Assay by Fluorescence Polarization

Silva Khodjoyan , Deborha Morissette , Fortune Hontonnou , Luis Checa Ruano , Charles-Adrien Richard et al.
International Journal of Molecular Sciences, 2023, 24 (1), pp.569. ⟨10.3390/ijms24010569⟩
Article dans une revue hal-04012024 v1
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Characterization of the Interaction Domains between the Phosphoprotein and the Nucleoprotein of Human Metapneumovirus

Hortense Decool , Benjamin Bardiaux , Luis Checa Ruano , Olivier Sperandio , Jenna Fix et al.
Journal of Virology, 2022, 96 (2), pp.e0090921. ⟨10.1128/JVI.00909-21⟩
Article dans une revue hal-03579501 v2
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Importance of RNA length for in vitro encapsidation by the nucleoprotein of human respiratory syncytial virus

Lorène Gonnin , Charles-Adrien Richard , Irina Gutsche , Didier Chevret , Joris Troussier et al.
Journal of Biological Chemistry, 2022, 298 (9), pp.102337. ⟨10.1016/j.jbc.2022.102337⟩
Article dans une revue hal-03797501 v2
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Tetramerization of Phosphoprotein Is Essential for Respiratory Syncytial Virus Budding while Its N-Terminal Region Mediates Direct Interactions with the Matrix Protein

Monika Bajorek , Marie Galloux , Charles-Adrien Richard , Or Szekely , Rina Rosenzweig et al.
Journal of Virology, 2021, 95, ⟨10.1128/jvi.02217-20⟩
Article dans une revue hal-04635668 v2
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Tetramerization of Phosphoprotein Is Essential for Respiratory Syncytial Virus Budding while Its N-Terminal Region Mediates Direct Interactions with the Matrix Protein

Monika Bajorek , Marie Galloux , Charles-Adrien Richard , Or Szekely , Rina Rosenzweig et al.
Journal of Virology, 2021, 95 (7), ⟨10.1128/JVI.02217-20⟩
Article dans une revue hal-03352808 v1
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PB1-F2 amyloid-like fibers correlate with proinflammatory signaling and respiratory distress in influenza-infected mice

Christophe Chevalier , Olivier Leymarie , Laura Sedano , Bruno da Costa , Charles-Adrien Richard et al.
Journal of Biological Chemistry, 2021, 297 (1), ⟨10.1016/j.jbc.2021.100885⟩
Article dans une revue hal-03299147 v1
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Targeting the Respiratory Syncytial Virus N 0 -P Complex with Constrained α-Helical Peptides in Cells and Mice

Marie Galloux , Nadège Gsponer , Vanessa Gaillard , Brice Fenner , Thibaut Larcher et al.
Antimicrobial Agents and Chemotherapy, 2020, 64 (10), ⟨10.1128/AAC.00717-20⟩
Article dans une revue hal-03353101 v1
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De novo protein design enables the precise induction of RSV-neutralizing antibodies

Fabian Sesterhenn , Che Yang , Jaume Bonet , Johannes T. Cramer , Xiaolin Wen et al.
Science, 2020, 368 (6492), ⟨10.1126/science.aay5051⟩
Article dans une revue hal-02677103 v1
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Minimal Elements Required for the Formation of Respiratory Syncytial Virus Cytoplasmic Inclusion Bodies In Vivo and In Vitro

Marie Galloux , Jennifer Risso-Ballester , Charles-Adrien Richard , Jenna Fix , Marie-Anne Rameix-Welti et al.
mBio, 2020, 11 (5), ⟨10.1128/mBio.01202-20⟩
Article dans une revue hal-02954783 v1

Does intrinsic disorder in proteins favor their Interaction with lipids?

Evgenia Deryusheva , Ekaterina Nemashkalova , Marie Galloux , Charles-Adrien Richard , Jean Francois Eleouet et al.
Proteomics, 2019, 19 (6), pp.1-9. ⟨10.1002/pmic.201800098⟩
Article dans une revue hal-02626958 v1
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A DNA vaccine encoding the Gn ectodomain of Rift Valley Fever virus protects mice via a humoral response decreased by DEC205 targeting

Tiphany Chrun , Sandra Lacote , Celine Urien , Charles-Adrien Richard , Matthias Tenbusch et al.
Frontiers in Immunology, 2019, 10, 15 p. ⟨10.3389/fimmu.2019.00860⟩
Article dans une revue hal-02624043 v1
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The interactome analysis of the Respiratory Syncytial Virus protein M2-1 suggests a new role in viral mRNA metabolism post- transcription

Camille Bouillier , Gina Cosentino , Thibaut Leger , Vincent Rincheval , Charles-Adrien Richard et al.
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-51746-0⟩
Article dans une revue hal-02907594 v1
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Biochemical characterization of the respiratory syncytial virus N0-P complex in solution

Camille Esneau , Bertrand Raynal , Pierre Roblin , Sébastien Brûlé , Charles-Adrien Richard et al.
Journal of Biological Chemistry, 2019, 294 (10), pp.3647-3660. ⟨10.1074/jbc.RA118.006453⟩
Article dans une revue hal-02276899 v1
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RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription

Charles-Adrien Richard , Vincent Rincheval , Safa Lassoued , Jenna Fix , Christophe Cardone et al.
PLoS Pathogens, 2018, 14 (3), pp.e1006920. ⟨10.1371/journal.ppat.1006920⟩
Article dans une revue hal-01740353 v1
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First demonstration of the circulation of a pneumovirus in French pigs by detection of anti-swine orthopneumovirus nucleoprotein antibodies

Charles-Adrien Richard , Caroline Hervet , Déborah Ménard , Irina Gutsche , Valérie Normand et al.
BMC Veterinary Research, 2018, 49 (1), ⟨10.1186/s13567-018-0615-x⟩
Article dans une revue hal-01964289 v1
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The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex

Muniyandi Selvaraj , Kavestri Yegambaram , Eleanor J a A Todd , Charles-Adrien Richard , Rachel L Dods et al.
mBio, 2018, 9 (6), ⟨10.1128/mBio.01554-18⟩
Article dans une revue hal-04283277 v1
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The structure of the human respiratory syncytial virus M2-1 protein bound to the interaction domain of the phosphoprotein P defines the orientation of the complex

Muniyandi Selvaraj , Kavestri Yegambaram , Eleanor J. A. A. Todd , Charles-Adrien Richard , Rachel L. Dods et al.
mBio, 2018, 9 (6), ⟨10.1128/mBio.01554-18⟩
Article dans une revue hal-02621034 v1
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Reversible unfolding of infectious prion assemblies reveals the existence of an oligomeric elementary brick

Angélique Igel-Egalon , Mohammed Moudjou , Davy Martin , Alexandra Busley , Tina Knäpple et al.
PLoS Pathogens, 2017, 13 (9), ⟨10.1371/journal.ppat.1006557⟩
Article dans une revue hal-02619876 v1
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Corrigendum: A Universal Influenza Vaccine Can Lead to Disease Exacerbation or Viral Control Depending on Delivery Strategies

Cindy Bernelin-Cottet , Charlotte Deloizy , Ondrej Stanek , Céline Barc , Edwige Bouguyon et al.
Frontiers in Immunology, 2017, 8, pp.831. ⟨10.3389/fimmu.2017.00831⟩
Article dans une revue hal-02618722 v1
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N-terminal domain of PB1-F2 protein of influenza A virus can fold into amyloid-like oligomers and damage cholesterol and cardiolipid containing membranes

Dalila Ajjaji , Charles-Adrien Richard , Sandra Mazerat , Christophe Chevalier , Jasmina Vidic
Biochemical and Biophysical Research Communications, 2016, 477 (1), pp.27-32. ⟨10.1016/j.bbrc.2016.06.016⟩
Article dans une revue hal-02636639 v1
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A Universal Influenza Vaccine Can Lead to Disease Exacerbation or Viral Control Depending on Delivery Strategies

Cindy Bernelin-Cottet , Charlotte Deloizy , Ondrej Stanek , Céline Barc , Edwige Bouguyon et al.
Frontiers in Immunology, 2016, 8, pp.1-1. ⟨10.3389/fimmu.2016.00641⟩
Article dans une revue hal-01569908 v1
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Amyloid assemblies of influenza a virus PB1-F2 protein Damage membrane and induce cytotoxicity

Jasmina Vidic , Charles-Adrien Richard , Christine Péchoux , Bruno B. da Costa , Nicolas N. Bertho et al.
Journal of Biological Chemistry, 2016, 291 (2), pp.739-751. ⟨10.1074/jbc.M115.652917⟩
Article dans une revue hal-02637618 v1
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Targeting human respiratory syncytial virus transcription anti-termination factor M2-1 to inhibit <em>in vivo</em> viral replication

B. Bailly , Charles-Adrien Richard , G. Sharma , L. Wang , L. Johansen et al.
Scientific Reports, 2016, 6, ⟨10.1038/srep25806⟩
Article dans une revue hal-02637632 v1

Interaction between Shadoo and PrP Affects the PrP-Folding Pathway

Danica Ciric , Charles-Adrien Richard , Mohammed Moudjou , Jérôme Chapuis , Pierre Sibille et al.
Journal of Virology, 2015, 89 (12), pp.6287-6293. ⟨10.1128/JVI.03429-14⟩
Article dans une revue hal-02636090 v1

Identification and Characterization of the Binding Site of the Respiratory Syncytial Virus Phosphoprotein to RNA-Free Nucleoprotein

Marie Galloux , Gaëlle Gabiane , Julien Sourimant , Charles-Adrien Richard , Patrick England et al.
Journal of Virology, 2015, 89 (7), pp.3484-3496. ⟨10.1128/jvi.03666-14⟩
Article dans une revue hal-04678676 v1

Purification and Refolding to Amyloid Fibrils of (His)-tagged Recombinant Shadoo Protein Expressed as Inclusion Bodies in [i]E. Coli[/i]

Qiaojing Li , Charles-Adrien Richard , Mohammed Moudjou , Jasmina Vidic
Journal of visualized experiments : JoVE, 2015, 106, ⟨10.3791/53432⟩
Article dans une revue hal-01309645 v1
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Highly infectious prions generated by a single round of microplate-based protein misfolding cyclic amplification

Mohammed M. Moudjou , Pierre Sibille , Guillaume Fichet , Fabienne Reine , Jerome Chapuis et al.
mBio, 2014, 5 (1), ⟨10.1128/mBio.00829-13⟩
Article dans une revue hal-02636078 v1

Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation

Sian J. Tanner , Antonio Ariza , Charles-Adrien Richard , Hannah F. Kyle , Rachel L. Dods et al.
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (4), pp.1580-1585. ⟨10.1073/pnas.1317262111⟩
Article dans une revue hal-02631183 v1

Electrochemical Detection of the Oligomerization of PB1-F2 Influenza A Virus Protein in Infected Cells

Anna Miodek , Jasmina Vidic , Helene Sauriat-Dorizon , Charles-Adrien Richard , Ronan Le Goffic et al.
Analytical Chemistry, 2014, 86 (18), pp.9098 - 9105. ⟨10.1021/ac5018056⟩
Article dans une revue hal-02635306 v1
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Highly Infectious Prions Generated by a Single Round of Microplate-Based Protein Misfolding Cyclic Amplification

Mohammed Moudjou , Pierre Sibille , Guillaume Fichet , Fabienne Reine , Jérôme Chapuis et al.
mBio, 2014, 5 (1), ⟨10.1128/mBio.00829-13⟩
Article dans une revue hal-03402322 v1
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Detection of soluble oligomers formed by PB1-F2 influenza A virus protein in vitro

Jasmina Vidic , Ronan Le Goffic , Anna Miodek , Christiane Bourdieu , Charles-Adrien Richard et al.
Journal of Analytical & Bioanalytical Techniques, 2013, 4 (3), pp.1-2. ⟨10.4172/2155-9872.1000169⟩
Article dans une revue hal-02642907 v1
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Surface plasmon resonance immunosensor for detection of pb1-f2 influenza a virus protein in infected biological samples

Jasmina Vidic , Christophe Chevalier , Ronan Le Goffic , Anna Miodek , Christiane Bourdieu et al.
Journal of Analytical & Bioanalytical Techniques, 2013, S7, ⟨10.4172/2155-9872.S7-006⟩
Article dans une revue hal-02642777 v1

Shadoo binds lipid membranes and undergoes aggregation and fibrillization

Qiaojing Li , Christophe Chevalier , Celine C. Henry , Charles-Adrien Richard , Mohammed M. Moudjou et al.
Biochemical and Biophysical Research Communications, 2013, 438 (3), pp.519 - 525. ⟨10.1016/j.bbrc.2013.07.104⟩
Article dans une revue istex hal-02643069 v1
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Molecular dynamics studies of the nucleoprotein of influenza A virus: role of the protein flexibility in RNA binding

Bogdan Tarus , Christophe Chevalier , Charles-Adrien Richard , Bernard B. Delmas , Carmelo Di Primo et al.
PLoS ONE, 2012, 7 (1), pp.e30038. ⟨10.1371/journal.pone.0030038⟩
Article dans une revue hal-02647086 v1

Development and validation of a method for fipronil residue determination in ovine plasma using 96-well plate solid-phase extraction and gas chromatography-tandem mass spectrometry

Emmanuelle Bichon , Charles-Adrien Richard , Bruno Le Bizec
Journal of Chromatography A, 2008, 1201 (1), pp.91-99. ⟨10.1016/j.chroma.2008.06.024⟩
Article dans une revue istex hal-02663818 v1

FINE-TUNED REGULATION OF THE RESPIRATORY SYNCYTIAL VIRUS NUCLEOPROTEIN BY POSTTRANSLATIONAL MODIFICATIONS

Vincent Basse , Julien Sourimant , Carine Machado Rodrigues , Céline Henry , Charles-Adrien Richard et al.
negative sense virus meeting 2025, Jun 2025, Montpellier, France
Communication dans un congrès hal-05156402 v1

Disordered, fuzzy and sticky: NMR insights into respiratory syncytial virus phosphoprotein, an adaptor-like protein.

Christophe Cardone , Silva Khodjoyan , Stéphanie Deville-Foillard , Philippe Durand , Charles-Adrien Richard et al.
Symposium ICSN60(2+), Jun 2022, Gif-sur-Yvette, France
Communication dans un congrès hal-04397333 v1

NMR insight into transient structures and interactions within the RNA polymerase of the bronchiolitis virus.

Christophe Cardone , Nelson Pereira , Safa Lassoued , Déborha Morissette , Charles-Adrien Richard et al.
EUROISMAR 2019, Aug 2019, Berlin, Germany
Communication dans un congrès hal-04397556 v1

Cartographie et caractérisation de la région d'interaction de la phosphoprotéine P avec la protéine M2-1 du Virus Respiratoire Syncytial

Charles-Adrien Richard , Safa Lassoued , Christina Sizun , Jean Francois Eleouet
13. Journées d'Animation Scientifique du Département de Santé Animale (JAS), May 2016, Futuroscope - Poitiers, France
Communication dans un congrès hal-01604086 v1
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Highly infectious prions generated by a single round of microplate-based protein misfolding cyclic amplification

Mohammed M. Moudjou , Pierre Sibille , Guillaume Fichet , Fabienne Reine , Jerome Chapuis et al.
International Prion Congress 2014, May 2014, Trieste, Italy. ⟨10.4161/pri.29370⟩
Communication dans un congrès hal-02739413 v1

Prion-like Shadoo protein and its interactions with lipid membranes.

Qiaojing Li , Danica Ciric , Charles-Adrien Richard , Stephane Biacchesi , Christophe Chevalier et al.
SFBBM-SFB congrès 2012, 2012, Grenoble, France
Communication dans un congrès hal-01191378 v1

Structural and dynamic insights into RSV phosphoprotein, a viral platform protein.

Christophe Cardone , Charles-Adrien Richard , Monika Bajorek , Jean-François Eleouet , Marie Galloux et al.
66th Biophysical Society Annual Meeting, Feb 2022, San Francisco (CA), United States
Poster de conférence hal-04397351 v1

Structural and dynamic insights by NMR into RSV phosphoprotein, a viral platform protein.

Christophe Cardone , Charles-Adrien Richard , Monika Bajorek , Jean-François Eleouet , Marie Galloux et al.
XXIVemes Journées Francophones de Virologie, Apr 2022, Strasbourg, France
Poster de conférence hal-04397347 v1

The identification of a porcine pneumovirus from an immunological perspective

Caroline Hervet , Charles-Adrien Richard , Irina Gutsche , Valérie Normand , Mily Leblanc-Maridor et al.
International Veterinary Immunology Symposium (IVIS), Aug 2019, Seattle, United States. , 176 p., 2019, International Veterinary Immunology Symposium (IVIS)
Poster de conférence hal-02737240 v1

Quand un virus pathogène détourne la machinerie cellulaire à son avantage

Charles-Adrien Richard , Vincent Rincheval , Christophe Cardone , Camille Esneau , Marie Galloux et al.
Journées d'Animation Scientifique du Département Santé Animale, Oct 2018, Nantes, France. 2018
Poster de conférence hal-01901481 v1
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Effect of mutations in the gene-end sequence on RSV transcription

Jean-François Eleouet , Charles-Adrien Richard
17. International Conference on Negative Strand Viruses (NSV 2018), Jun 2018, Vérone, Italy. , 354 p., 2018, 17th NSV 2018 - Abstract Book
Poster de conférence hal-01833633 v1

Dephosphorylation of respiratory syncytial M2-1 protein by the cellular phosphatase PP1 is required for its mRNA binding ability

Jean-François Eleouet , Charles-Adrien Richard , Vincent Rincheval , Christophe Cardone , Camille Esneau et al.
17. International Conference on Negative Strand Viruses (NSV 2018), Jun 2018, Vérone, Italy. , 354 p., 2018, 17th NSV 2018 - Abstract Book
Poster de conférence hal-01833641 v1

How structural order/disorder transitions modulate interactions in RSV phosphoprotein

Christophe Cardone , Nelson Pereira , Safa Lassoued , Charles-Adrien Richard , Jenna Fix et al.
19. IUPAB Congress / 11. EBSA Congress, Jul 2017, Édimbourg, United Kingdom. Editions Springer, European Biophysics Journal, 46 (Supplement 1), 449 p., 2017, 19th IUPAB and 11th EBSA Congress, Edinburgh, Scotland, 16–20 July, 2017 – Abstracts. ⟨10.1007/s00249-017-1222-x⟩
Poster de conférence hal-02738385 v1

La phosphoprotéine P du Virus Respiratoire Syncytial recrute la protéine phosphatase-1 cellulaire afin de réguler la phosphorylation de M2-1, facteur viral de transcription, ainsi que son activité

Charles-Adrien Richard , Safa Lassoued , Jenna Fix , Camille Esneau , Sergeï Nekhai et al.
19. Journées Francophones de Virologie, Mar 2017, Paris, France. John Libbey Eurotex, Virologie, 21 (2), pp.112, 2017, Virologie
Poster de conférence hal-01545647 v1

Cartographie et caractérisation du domaine d'interaction de la Phosphoprotéine P avec le protéine M2-1 du Virus Respiratoire Syncytial Humain

Charles-Adrien Richard , Safa Lassoued , Christina Sizun , Jean Francois Eleouet
XVIIIièmes Journées Francophones de Virologie, Mar 2016, Paris, France. Virologie, 20 (2), 136 p., 2016, Virologie. ⟨10.1684/vir.2016.0641⟩
Poster de conférence hal-01491465 v1

La protéine M2-1 du Virus Respiratoire Syncytial, une nouvelle cible potentiel pour des antiviraux

Charles-Adrien Richard , Benjamin Bailly , Ralf Altmeyer , John N. Barr , Jean Francois Eleouet
XVIIièmes Journées Francophones de Virologie, Apr 2015, Paris, France. Virologie, 19 (2), pp.108, 2015, Virologie. ⟨10.1684/vir.2015.0596⟩
Poster de conférence hal-01354216 v1
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Fine mapping and characterization of the binding domain of the HRSV Phosphoprotein with the M2-1 protein

Charles-Adrien Richard , Anne-Laure Gaillard , Camille Esneau , Christina Sizun , Jean Francois Eleouet
16. International Conference on Negative Strand Viruses, Jun 2015, Siena, Italy. , 2015
Poster de conférence hal-01408013 v1
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Etude fonctionnelle de la protéine M2-1 du virus respiratoire syncytial à l'aide d'un miniréplicon en cellules eucaryotes

Charles-Adrien Richard , Marie-Lise Blondot , Jean Francois Eleouet
16. Journées Francophones de Virologie, 2014, Paris, France. Virologie, 18 (suppl.), pp.72, 2014, Virologie
Poster de conférence hal-01309646 v1

Etude fonctionnelle de la protéine M2-1 du virus respiratoire syncytial à l'aide d'un minigénome en cellules eucaryotes

Charles-Adrien Richard , Marie-Lise Blondot , Jean-François Eléouët
Journées d'Animation Scientifique du Département Santé Animale, Oct 2013, Cap d'Agde, France. 2013
Poster de conférence hal-02750318 v1