Charline Kieffer

18
Documents

Publications

Publications

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UBE2N: Hope on the Cancer Front, How to Inhibit This Promising Target Prospect?

Florian Schwalen , Côme Ghadi , Léonie Ibazizene , Shafi Ullah Khan , Jana Sopkova-de Oliveira Santos et al.

Journal of Medicinal Chemistry, 2025, ⟨10.1021/acs.jmedchem.4c01517⟩

Article dans une revue hal-04885402v1

PROTAC 2.0: Expanding the frontiers of targeted protein degradation

Marie Cornu , Thomas Lemaitre , Charline Kieffer , Anne Sophie Voisin-Chiret

Drug Discovery Today, 2025, 30 (6), pp.104376. ⟨10.1016/j.drudis.2025.104376⟩

Article dans une revue hal-05472074v1

Towards New Anti‐inflammatory Agents: Design, Synthesis and Evaluation of Molecules Targeting XIAP‐BIR2

Marc Ragui Farag , Nicolas Guedeney , Florian Schwalen , Aymeric Zadorovnyj , Amelie Barczyk et al.

ChemMedChem, 2024, pp.e202400567. ⟨10.1002/cmdc.202400567⟩

Article dans une revue hal-04772005v1

Molecular glue degraders: exciting opportunities for novel drug discovery

Thomas Lemaitre , Marie Cornu , Florian Schwalen , Marc Since , Charline Kieffer et al.

Expert Opinion on Drug Discovery, 2024, 19 (4), pp.433-449. ⟨10.1080/17460441.2024.2306845⟩

Article dans une revue hal-04711906v1
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Target fishing reveals PfPYK-1 and PfRab6 as potential targets of an antiplasmodial 4-anilino-2-trichloromethylquinazoline hit compound

C. Kieffer , N. Primas , S. Hutter , A. Merckx , L. Reininger et al.

Bioorganic and Medicinal Chemistry, 2024, 102, pp.117654. ⟨10.1016/j.bmc.2024.117654⟩

Article dans une revue hal-04503278v1

PROTAC technology: A new drug design for chemical biology with many challenges in drug discovery

Nicolas Guedeney , Marie Cornu , Florian Schwalen , Charline Kieffer , Anne Sophie Voisin-Chiret

Drug Discovery Today, 2023, 28 (1), pp.103395. ⟨10.1016/j.drudis.2022.103395⟩

Article dans une revue hal-03936766v1
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Computational Tool to Design Small Synthetic Inhibitors Selective for XIAP-BIR3 Domain

Marc Farag , Charline Kieffer , Nicolas Guedeney , Anne Sophie Voisin-Chiret , Jana Sopkova-de Oliveira Santos

Molecules, 2023, 28 (13), pp.5155. ⟨10.3390/molecules28135155⟩

Article dans une revue hal-04222485v1
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Computational Tool to Design Small Synthetic Inhibitors Selective for XIAP-BIR3 Domain

Marc Farag , Charline Kieffer , Nicolas Guedeney , Anne Sophie , Jana Sopkova-de Oliveira Santos Article dans une revue hal-04148037v1
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Noncellular screening for the discovery of protein–protein interaction modulators

Charline Kieffer , Jean Pierre Jourdan , Marie Jouanne , Anne Sophie Voisin-Chiret

Drug Discovery Today, 2020, 25, pp.1592 - 1603. ⟨10.1016/j.drudis.2020.07.012⟩

Article dans une revue hal-03493870v1
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Discovery of new hit-molecules targeting Plasmodium falciparum through a global SAR study of the 4-substituted-2-trichloromethylquinazoline antiplasmodial scaffold

Justine Desroches , Charline Kieffer , Nicolas Primas , Sébastien Hutter , Armand Gellis et al.

European Journal of Medicinal Chemistry, 2017, 125 (128), pp.68-86. ⟨10.1016/j.ejmech.2016.09.029⟩

Article dans une revue hal-01416990v1

Sequential one pot double C H heteroarylation of thiophene using bromopyridines to synthesize unsymmetrical 2,5-bipyridylthiophenes

Charline Kieffer , Victor Babin , Marie Jouanne , Ikram Slimani , Yohann Berhault et al.

Tetrahedron, 2017, 73 (37), pp.5509-5516. ⟨10.1016/j.tet.2017.07.049⟩

Article dans une revue istex hal-02043719v1

Preventing the contamination of hospital personnel by cytotoxic agents: evaluation and training of the para-professional healthcare workers in oncology units

C. Kieffer , Pierre Verhaeghe , S. Lagrassa , R. Gregoire , Z. Moussaoui et al.

European Journal of Cancer Care, 2015, 24 (3), pp.404-410. ⟨10.1111/ecc.12249⟩

Article dans une revue istex hal-01460563v1

Antileishmanial pharmacomodulation in 8-nitroquinolin-2(1H)-one series

Charline Kieffer , Anita Cohen , Pierre Verhaeghe , Lucie Paloque , Sébastien Hutter et al.

Bioorganic and Medicinal Chemistry, 2015, 23 (10), pp.2377-2386. ⟨10.1016/j.bmc.2015.03.064⟩

Article dans une revue istex hal-01460646v1

Looking for new antileishmanial derivatives in 8-nitroquinolin-2(1H)-one series

Charline Kieffer , Anita Cohen , Pierre Verhaeghe , Sébastien Hutter , Caroline Castera-Ducros et al.

European Journal of Medicinal Chemistry, 2015, 92, pp.282-294. ⟨10.1016/j.ejmech.2014.12.056⟩

Article dans une revue istex hal-01460569v1
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Synthesis and in vitro evaluation of 4-trichloromethylpyrrolo[1,2-a]quinoxalines as new antiplasmodial agents

Nicolas Primas , Peggy Suzanne , Pierre Verhaeghe , Sébastien Hutter , Charline Kieffer et al.

European Journal of Medicinal Chemistry, 2014, 83, pp.26-35. ⟨10.1016/j.ejmech.2014.06.014⟩

Article dans une revue hal-01417058v1
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A new DMAP-catalyzed and microwave-assisted approach for introducing heteroarylamino substituents at position 4 of the quinazoline ring.

Armand Gellis , Charline Kieffer , Nicolas Primas , Gilles Lanzada , Michel Giorgi et al.

Tetrahedron, 2014, 78 (44), pp.8257-8266. ⟨10.1016/j.tet.2014.09.024⟩

Article dans une revue hal-01417081v1

Sonogashira cross-coupling reaction in 4-chloro-2-trichloromethylquinazoline series is possible despite a side dimerization reaction

Charline Kieffer , Pierre Verhaeghe , Nicolas Primas , C. Castera-Ducros , A. Gellis et al.

Tetrahedron, 2013, 69 (14), pp.2987-2995. ⟨10.1016/j.tet.2013.01.094⟩

Article dans une revue istex hal-00821454v1
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A New Synthetic Route to Original Sulfonamide Derivatives in 2-Trichloromethylquinazoline Series: A Structure-Activity Relationship Study of Antiplasmodial Activity

Nicolas Primas , Pierre Verhaeghe , Anita Cohen , Charline Kieffer , Aurélien Dumètre et al.

Molecules, 2012, 17 (7), pp.8105-8117. ⟨10.3390/molecules17078105⟩

Article dans une revue hal-01772858v1