Charly Helaine

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Publications

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Injectable Biocompatible Zeolite Nanocrystals for Enhanced Tumor Oxygenation and MRI Imaging

Abdallah Amedlous , C Hélaine , Francesco Dalena , Clément Anfray , Thomas Ménard et al.
ACS Applied Materials & Interfaces, 2025, 17 (5), pp.8003-8016. ⟨10.1021/acsami.4c20383⟩
Article dans une revue hal-04920878 v1
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In vivo biodistribution and tumor uptake of [64Cu]-FAU nanozeolite via positron emission tomography Imaging

Charly Hélaine , Abdallah Amedlous , Jérôme Toutain , Carole Brunaud , Oleg Lebedev et al.
Nanoscale, 2024, 16, pp.11959-11968. ⟨10.1039/d3nr05947b⟩
Article dans une revue hal-04614420 v1
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Gadolinium-loaded LTL nanosized zeolite for efficient oxygen delivery and magnetic resonance imaging

Abdallah Amedlous , C Hélaine , Rémy Guillet-Nicolas , Oleg Lebedev , Valable Samuel et al.
Inorganic Chemistry Frontiers, 2023, 10 (9), pp.2665-2676. ⟨10.1039/D3QI00169E⟩
Article dans une revue hal-04250335 v1
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Assessment of hypoxia and oxidative-related changes in a lung-derived brain metastasis model by [64Cu][Cu(ATSM)] PET and proteomic studies

Jade Fantin , Jérôme Toutain , Elodie A. Pérès , Benoit Bernay , Sarina Maya Mehani et al.
EJNMMI Research, 2023, 13 (102), ⟨10.1186/s13550-023-01052-8⟩
Article dans une revue hal-04308804 v1
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Functional impact of oxygen-saturated zeolite nanoparticles on macrophages in the context of glioblastoma: an in vitro and in vivo study

Aurélie E Ferre , Sarah Komaty , C Hélaine , Clément Anfray , Sajjad Ghojavand et al.
Colloids and Surfaces B: Biointerfaces, 2023, 230, pp.113524. ⟨10.1016/j.colsurfb.2023.113524⟩
Article dans une revue hal-04190367 v1
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Internalization study of nanosized zeolite crystals in human glioblastoma cells

C Hélaine , Hayriye Özçelik , Sarah Komaty , Abdallah Amedlous , Sajjad Ghojavand et al.
Colloids and Surfaces B: Biointerfaces, 2022, 218, pp.112732. ⟨10.1016/j.colsurfb.2022.112732⟩
Article dans une revue hal-03752239 v1
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Angiopoietin-2 Combined with Radiochemotherapy Impedes Glioblastoma Recurrence by Acting in an Autocrine and Paracrine Manner: A Preclinical Study

Charly Hélaine , Aurélie Ferré , Marine Leblond , Elodie Pérès , Myriam Bernaudin et al.
Cancers, 2020, 12 (12), pp.3585. ⟨10.3390/cancers12123585⟩
Article dans une revue hal-03082539 v1
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Nanosized zeolites as a gas delivery platform in a glioblastoma model

Clement Anfray , Sarah Komaty , Aurélien Corroyer-Dulmont , Moussa Zaarour , Charly Hélaine et al.
Biomaterials, 2020, 257, pp.120249. ⟨10.1016/j.biomaterials.2020.120249⟩
Article dans une revue hal-02912573 v1

Copper exchanged FAU nanozeolite as non-toxic nitric oxide and carbon dioxide gas carrier

Kamila Goldyn , Clément Anfray , Sarah Komaty , Valerie Ruaux , Charly Hélaine et al.
Microporous and Mesoporous Materials, 2019, Special Issue dedicated to the 65 birthday of Prof. Wieslaw J. Roth, 280, pp.271-276. ⟨10.1016/j.micromeso.2019.02.022⟩
Article dans une revue hal-02086878 v1

M2 macrophages are more resistant than M1 macrophages following radiation therapy in the context of glioblastoma

Marine Leblond , Elodie A. Pérès , Charly Hélaine , Aurélie Gérault , Damien Moulin et al.
Oncotarget, 2017, 8 (42), pp.72597-72612. ⟨10.18632/oncotarget.19994⟩
Article dans une revue hal-02100869 v1

Overcoming chemoresistance in glioblastoma with fenofibrate-loaded nanoemulsions combined with iron oxide nanoparticles (SPIONs)

Yasmine Chokry , Anne-Claire Groo , Ons Ben Hadj Hassen , C Hélaine , Katel Hervé-Aubert et al.
16èmes Journées Scientifiques du Cancéropôle Nord-Ouest, May 2024, Deauville, France
Communication dans un congrès hal-04683731 v1

Development and validation of a new theranostic textile material by MRI for the treatment of chemoresistant cancers

Géraldine Gouhier , Bernard Martel , Laura Gouriou , François Estour , Ramakrishna Gandikota et al.
21st International Cyclodextrin Symposium, Jun 2024, Dunkerque, France
Communication dans un congrès hal-04683679 v1

Magnetic supramolecular assemblies based on amphiphilic cyclodextrins with intratumoral theranostic features

Antonino Mazzaglia , Roberto Zagami , Angela Scala , Anna Piperno , C Hélaine et al.
21st International Cyclodextrin Symposium, Jun 2024, Dunkerque, France
Communication dans un congrès hal-04683664 v1

Preclinical study of the comparative effects of protons vs conventional x-rays radiotherapy on radiation-induced lymphopenia in the context of brain irradiation

Julie Coupey , Thao-Nguyen Pham , Jérôme Toutain , Viktoriia Ivanova , Erika Hue et al.
Journées de l'EDnBISE 2023, Jun 2023, Rouen, France
Communication dans un congrès hal-04685305 v1

Hadrontherapy to target glioblastoma stem cells to overcome radioresistance

Juliette Aury-Landas , E.A. Pérès , Nolwenn Pasquet , C Hélaine , D Lebhertz et al.
Assemblée générale du GDR Mi2B (Outils et méthodes nucléaires pour la lutte contre le cancer), Oct 2023, Bordeaux, France
Communication dans un congrès hal-04262139 v1

Investigating the effects of protons vs conventional x-rays on radiation-induced lymphopenia in a context of brain irradiation

Julie Coupey , Thao-Nguyen Pham , Jérôme Toutain , Viktoriia Ivanova , Erika Hue et al.
Journées Resplandir, Mar 2023, Strasbourg, France
Communication dans un congrès hal-04685282 v1

Comparative study of proton versus X-rays on circulating leukocytes in a context of brain irradiation: a preclinical study

Samuel Valable , Julie Coupey , Thao Nguyen Pham , Jérôme Toutain , V. Ivanova et al.
Premier congrès de radiobiologie de la SFBR, SFBR, Nov 2022, Agay-Saint Raphaël, France
Communication dans un congrès hal-03845697 v1

Comparative preclinical study of the effect of proton therapy versus conventional radiotherapy on circulating leukocytes in a context of brain tumour irradiation

Julie Coupey , Thao Nguyen Pham , Jérôme Toutain , Erika Hue , C Hélaine et al.
5th Conference on Small Animal Precision Image-Guided Radiotherapy, Mar 2022, Munich, Germany
Communication dans un congrès hal-03618448 v1

Preclinical study of the interest of proton therapy vs conventional x-ray to limit radiation-induced lymphopenia in a context of brain irradiation

Julie Coupey , Thao-Nguyen Pham , Jérôme Toutain , Viktoriia Ivanova , Erika Hue et al.
RadioTransNet, Nov 2022, Caen, France
Communication dans un congrès hal-04685066 v1

Investigating the interest of proton therapy to obtund radiation-induced lymphopenia in a context of brain tumour irradiation: a preclinical study

Julie Coupey , Jérôme Toutain , Erika Hue , C Hélaine , Jade Richard et al.
“Adaptation of the tumour and its ecosystem to radiotherapies“ workshop (14th CGO), Sep 2021, Le Bono, France
Communication dans un congrès hal-03444560 v1

Impact of tumor reoxygenation by nanoparticles on tumors associated macrophages.

A Ferré , H Ozcelik , M.M. Leblond , C Anfray , C Hélaine et al.
24ème édition des journées de l'école doctorale EdNBISE, Mar 2019, Caen, France
Communication dans un congrès hal-02266827 v1

Interventions en écoles

A Corroyer-Dulmont , G Ropars , L Chazalviel , O Touzani , Y Khelif et al.
Semaine du Cerveau, Mar 2017, Villy Bocage, France
Communication dans un congrès hal-02331958 v1

Overcoming chemoresistance in glioblastoma with fenofibrate-loaded nanoemulsions

Yasmine Chokry , Anne-Claire Groo , Sophie Corvaisier , C Hélaine , Aurélie Malzert-Fréon et al.
17èmes Journées Scientifiques du CNO, May 2025, DEAUVILLE, France
Poster de conférence hal-05080050 v1

Overcoming chemoresistance in glioblastoma with fenofibrate-loaded nanoemulsions combined with iron oxide nanoparticles (SPIONs)

Yasmine Chokry , Anne-Claire Groo , Ons Ben Hadj Hassen , C Hélaine , Katel Hervé-Aubert et al.
Journées de l'Ecole Doctorale nBISE, May 2024, Deauville, France
Poster de conférence hal-04683975 v1

Nanoemulsions combining fenofibrate and SPIONs for the treatment of glioblastoma

Yasmine Chokry , Anne-Claire Groo , Ons Ben Hadj Hassen , C Hélaine , Hervé-Aubert Katel et al.
50ième anniversaire du Centre d’Etudes et de Recherche sur le Médicament de Normandie, Nov 2024, Caen, France
Poster de conférence hal-04835492 v1

Overcoming chemoresistance in glioblastoma with fenofibrate-loaded nanoemulsions combined with iron oxide nanoparticles (SPIONs)

Yasmine Chokry , Anne-Claire Groo , Ons Ben Hadj Hassen , C Hélaine , Katel Hervé-Aubert et al.
16èmes Journées Scientifiques du Cancéropôle Nord-Ouest, May 2024, Deauville, France
Poster de conférence hal-04683996 v1

Nanoemulsions combining fenofibrate and SPIONs for the treatment of glioblastoma

Yasmine Chokry , Anne-Claire Groo , Ons Ben Hadj Hassen , C Hélaine , Katel Hervé-Aubert et al.
14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Mar 2024, Vienne, Austria
Poster de conférence hal-04683954 v1

Understanding the effects of protons versus x-rays on radiation-induced lymphopenia after brain irradiation: a preclinical study

Julie Coupey , Thao-Nguyen Pham , Jérôme Toutain , Viktoriia Ivanova , Erika Hue et al.
FENS 2024, Jun 2024, Vienne, Austria
Poster de conférence hal-04685339 v1

Overcoming hypoxia induced chemoresistance with fenofibrate-loaded nanoemulsions in glioblastoma

Yasmine Chokry , Anne-Claire Groo , C Hélaine , Aurélie Malzert-Fréon , Valable Samuel
Journée Normande de Recherche Biomédicale (JNRB), Jun 2023, Caen, France
Poster de conférence hal-04192455 v1

Protons or X-rays-based radiotherapy: a preclinical study of the comparative effects on radiation-induced lymphopenia in the context of brain irradiation

Julie Coupey , Pham Thao-Nguyen , Jérôme Toutain , Ivanova Viktoriia , Hue Erika et al.
15èmes journées scientifiques du Cancéropôle Nord-Ouest, May 2023, Deauville, France
Poster de conférence hal-04685329 v1

Kinetics and oxygen dependence of uptake of nanozeolites by human glioblastoma cells

C Hélaine , Hayriye Özçelik , S. Komaty , A. Amedlous , Sajjad Ghojavand et al.
Groupe Français des Zéolithes, Mar 2022, Voguë, France
Poster de conférence hal-03643253 v1

Preclinical study of the effects of proton therapy vs conventional X-rays on circulating leukocytes to obtund radiation-induced lymphopenia in a context of brain tumor irradiation

Julie Coupey , Thao Nguyen Pham , Jérôme Toutain , Erika Hue , C Hélaine et al.
14èmes journées scientifiques du Cancéropôle Nord-Ouest, May 2022, Deauville, France
Poster de conférence hal-03699322 v1

Investigating the interest of proton therapy to obtund radiation-induced lymphopenia in a context of brain tumour irradiation: a preclinical study

Julie Coupey , Jérôme Toutain , Erika Hue , C Hélaine , Jade Richard et al.
46th Annual Meeting of the European Radiation Research Society (ERRS 2021), Nov 2021, Caen, France.
Poster de conférence hal-03444552 v1

Ang2 overexpression optimizes the efficacy of radiochemotherapy in glioblastoma by acting in an autocrine and paracrine manner

C Hélaine , Aurélie Ferré , M.M. Leblond , Elodie A. Pérès , Myriam Bernaudin et al.
SF Angiogenèse, Nov 2021, e-congrès, France
Poster de conférence hal-03557900 v1

Preclinical study of the effects of proton therapy vs conventional X-rays on circulating leukocytes to obtund radiation-induced lymphopenia in a context of brain tumor irradiation

Julie Coupey , Jérôme Toutain , Erika Hue , C Hélaine , Jade Richard et al.
46th Annual Meeting for the European Radiation Research Society, Nov 2021, Caen, France
Poster de conférence hal-03699307 v1

Interest of various radiothérapies to modulate glioblastoma inflammation

A.E. Ferré , M.M. Leblond , Charly Hélaine , E.A. Pérès , Petit Edwige et al.
ENLIGHT meeting 2019, Jul 2019, Caen, France
Poster de conférence hal-02328451 v1

Impact de stratégies nanoparticulaires de réoxygénation sur les macrophages associés aux glioblastomes.

Aurélie Ferré , Clement Anfray , M.M. Leblond , H. Ozcelik , Charly Hélaine et al.
12èmes journées scientifiques du Cancéropôle Nord-Ouest, May 2019, Deauville, France
Poster de conférence hal-02266389 v1

Effets de la surexpression de Ang2 dans la récidive du glioblastome après chimio-radiothérapie

Charly Hélaine , Aurélie Ferré , M.M. Leblond , Aurélien Corroyer-Dulmont , E.A. Pérès et al.
Journée Normande de Recherche Biomédicale, JNRb, Nov 2019, Caen, France
Poster de conférence hal-02318474 v1

Effets de la surexpression de Ang2 dans la récidive du glioblastome après chimio-radiothérapie.

Charly Hélaine , Aurélie Ferré , M.M. Leblond , Corroyer-Dulmont Aurélien , E.A. Pérès et al.
12èmes journées scientifiques du Cancéropôle Nord-Ouest, May 2019, Deauville, France
Poster de conférence hal-02266383 v1

Interest of various radiotherapies to modulate glioblastoma inflammation

A.E. Ferré , M.M. Leblond , Charly Hélaine , E.A. Pérès , Petit Edwige et al.
Journée Normande de Recherche Biomédicale, JNRb, Nov 2019, Caen, France
Poster de conférence hal-02328559 v1

Influence of Ang2 overexpression in the recurrence of glioblastoma after chemo-radiotherapy.

Charly Hélaine , Aurélie Ferré , M.M. Leblond , Corroyer-Dulmont Aurélien , E.A. Pérès et al.
Journées de l’Ecole Doctorale EdNBise, Mar 2019, Caen, France
Poster de conférence hal-02266381 v1

Ang2 overexpression optimizes the efficacy of chemo-radiotherapy in glioblastoma

Charly Hélaine , Aurélie Ferré , M.M. Leblond , E.A. Pérès , Bernaudin Myriam et al.
LARC Neurosciences, Oct 2019, Nantes, France
Poster de conférence hal-02318483 v1

Impact of tumor reoxygenation by nanoparticles on Tumor Associated Macrophages (TAMs)

A.E. Ferré , Clément Anfray , M.M. Leblond , H. Ozcelik , Charly Hélaine et al.
European Society of Medical Oncology, Sep 2019, Barcelone, Spain. Annals of oncology, 30, pp.1999P, ⟨10.1093/annonc/mdz269.017⟩
Poster de conférence hal-02328503 v1

Impact of Angiopoietin-2 on glioblastoma response to combined chemo-radiotherapy

Charly Hélaine , Aurélie Ferré , M.M. Leblond , E.A. Pérès , Bernaudin Myriam et al.
European society for medical oncology, ESMO, Sep 2019, Barcelone, Spain. Annals of oncology, 30, pp.1997P
Poster de conférence hal-02266445 v1

A dialogue between endothelial cells and macrophages might contribute to vasculopathy in response to brain radiotherapy.

Charly Hélaine , An Gérault , M.M. Leblond , Corroyer-Dulmont Aurélien , Lambert G et al.
21e Journée de l'Ecole Doctorale NBISE, Mar 2018, Rouen, France
Poster de conférence hal-02266455 v1

Effect of radio-induced products from glioblastoma cells on macrophages

Aurélie Ferré , M.M. Leblond , Charly Hélaine , E.A. Pérès , Petit Edwige et al.
International Marie Sklodowska-Curie Meeting: From Radiation to Innovation in Medicine, Oct 2018, Paris, France
Poster de conférence hal-02266228 v1

Macrophages contribute to vascular damage after irradiation in glioblastoma: in vitro and in vivo studies

Charly Hélaine , Aurélie Ferré , M.M. Leblond , Gaelle Lambert , Divoux Didier et al.
International Marie Sklodowska-Curie Meeting: From Radiation to Innovation in Medicine, Oct 2018, Paris, France
Poster de conférence hal-02266224 v1

HAF inhibition in glioma cells reduces tumor growth without modifying the efficacy of chemo- and adiotherapy.

Lambert G , E.A. Pérès , Charly Hélaine , Didier Divoux , Jérôme Toutain et al.
25th Biennial Congress of the European Association for Cancer Research, Jun 2018, Amsterdam, Netherlands
Poster de conférence hal-02266195 v1

Involvement of tumor microenvironment on the sensitivity of glioblastoma vascularization to irradiation.

Charly Hélaine , Aurélie Ferré , M.M. Leblond , Gaelle Lambert , Divoux Didier et al.
SF Angiogenèse, Oct 2018, Reims, France. 2018
Poster de conférence hal-02266227 v1

Influence du microenvironnement tumoral sur la radiosensibilité de la composante vasculaire des glioblastomes : études in vivo et in vitro

Charly Hélaine , An Gérault , M.M. Leblond , Aurélie Ferré , Corroyer-Dulmont Aurélien et al.
Journée Normande de Recherche biomédicale, JNRb 2017, Nov 2017, Caen, France
Poster de conférence hal-02268986 v1

Etude de la radiosensibilité du compartiment vasculaire dans un contexte de glioblastome

Charly Hélaine , An Gérault , M.M. Leblond , Corroyer-Dulmont Aurélien , Gaelle Lambert et al.
10èmes journées scientifiques du Cancéropôle Nord-Ouest, May 2017, Deauville, France
Poster de conférence hal-02269210 v1

L’irradiation par rayons X favorise le phénotype M2 des macrophages dans les glioblastomes

M.M. Leblond , E.A. Pérès , An Gérault , Charly Hélaine , Clement Anfray et al.
10èmes journées scientifiques du Cancéropôle Nord-Ouest, May 2017, Deauville, France
Poster de conférence hal-02269183 v1