Christine Jean

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Publications

Publications

Cibler FAK fibroblastique pour normaliser le micro environnement du cancer du pancréas

Ismahane Belhabib , Sonia Zaghdoudi , Yvan Martineau , Corinne Bousquet , Christine Jean
Club d’Etudes des Cellules Epithéliales Digestives, Mar 2024, MONTPELLIER, France
Communication dans un congrès hal-04834073 v1

Tumoral mechanical stress reprograms adjacent tissue micro-environment to fuel pancreatic tumor progression: identification of a new subtype of activated fibroblasts.

Claire Lac , Pauline Thomas , Julie Foncy , Marjorie Fanjul , Laurent Malaquin et al.
Journée de l'Association Française pour la Recherche sur le Cancer du Pancréas., Sep 2024, Toulouse, France
Communication dans un congrès hal-04834786 v1

Do mechanical forces induce a protumoral dialogue between the tumor and the adjacent healthy tissue?

Claire Lac , Julie Foncy , Laurent Malaquin , Morgan Delarue , Corinne Bousquet et al.
International Pancreatic Cancer Symposium 2023, Oct 2023, Bordeaux, France
Communication dans un congrès hal-04834780 v1

A Comprehensive Study of a Pancreatic Cancer Subtype: The Interplay between Translation and Transcription in the Tumor Microenvironment.

Jacobo Solorzano , Mehdi Liauzun , Sauyeun Shin , Alexia Brunel , Christine Jean et al.
Translacore MC & WG meeting 2024, Apr 2024, Prague (CZ), Czech Republic
Communication dans un congrès hal-04872956 v1

FAK activity in CAF is a prognostic marker and a druggable key metastatic player in pancreatic cancer

Ismahane Belhabib , Sonia Zaghdoudi , Yvan Martineau , Corinne Bousquet , Christine Jean
Les Avancées Scientifiques de la Recherche en Biologie et Biotechnologe pour la Santé, Feb 2023, Toulouse, France
Communication dans un congrès hal-04834386 v1

A Comprehensive Study of a Pancreatic Cancer Subtype: The Interplay between Translation and Transcription in the Tumor Microenvironment

Jacobo Solorzano , Mehdi Liauzun , Sauyeun Shin , Alexia Brunel , Christine Jean et al.
Pancreatic Cancer Symposium 2023, Oct 2023, Bordeaux, France
Communication dans un congrès hal-04872923 v1

FAK kinase activity in cancer-associated fibroblasts impacts pancreatic ductal adenocarcinoma vascularization

Ismahane Belhabib , Sonia Zaghdoudi , Corinne Bousquet , Christine Jean
18èmes Journées du Cancéropôle GSO, Nov 2022, La grande Motte, France
Communication dans un congrès hal-04834347 v1

Do mechanical forces promote tumor progression via the establishment of a dialogue between the tumor and adjacent healthy tissue?

Claire Lac , Julie Foncy , Laurent Malaquin , Morgan Delarue , Corinne Bousquet et al.
Journée de l'Association Française de Recherche sur le Cancer du Pancréas, Oct 2022, Paris, France
Communication dans un congrès hal-04834760 v1

3D device to decipher the impact of tumoral compressive solid stress on adjacent tissue

Claire Lac , Julie Foncy , Laurent Malaquin , Morgan Delarue , Corinne Bousquet et al.
Les Translationnelles du GSO - Cancer du Pancréas, Dec 2022, Toulouse, France
Communication dans un congrès hal-04834772 v1

Les forces mécaniques induisent-elles un dialogue protumoral entre la tumeur et le tissu sain adjacent ?

Claire Lac , Julie Foncy , Laurent Malaquin , Morgan Delarue , Corinne Bousquet et al.
XXXVIème réunion du Club Français du Pancréas, Sep 2022, Paris, France
Communication dans un congrès hal-04834757 v1

L’imagerie en temps réel au service de la compréhension des mécanismes métastatiques

Christine Jean
Club Français du Pancréas, Sep 2021, Lyon, France
Communication dans un congrès hal-04834080 v1

Translatome-based classification reveals a dual metabolic dependency of a new tumor subtype of pancreatic cancer

Sauyeun Shin , Remy Nicolle , Christine Jean , Remi Samain , Mira Ayadi et al.
Club Français du Pancréas, Sep 2021, Lyon, France
Communication dans un congrès hal-04871736 v1

Translatome-based classification reveals a dual metabolic dependency of a new tumor subtype of pancreatic cancer

Sauyeun Shin , Remy Nicolle , Christine Jean , Remi Samain , Mira Ayadi et al.
Metabolism and Cancer 2021, May 2021, Bordeaux, France
Communication dans un congrès hal-04871717 v1

FAK kinase activity in cancer-associated fibroblasts impacts pancreatic ductal adenocarcinoma vascularization

Ismahane Belhabib , Sonia Zaghdoudi , Corinne Bousquet , Christine Jean
17èmes Journées du Cancéropôle GSO, Nov 2021, Carcasonne, France
Communication dans un congrès hal-04834279 v1

FAK kinase activity in cancer-associated fibroblasts impacts pancreatic ductal adenocarcinoma vascularization

Ismahane Belhabib , Sonia Zaghdoudi , Corinne Bousquet , Christine Jean
Journée scientifique de l’Association Française pour la Recherche sur le Cancer du Pancréas, Nov 2021, Paris, France
Communication dans un congrès hal-04834295 v1

RNAseq Analyses from Patient derived xenograft to decipher the stromal impact on the acquired chemoresistance to gemcitabine

Jérôme Raffenne , Rémi Samain , Alexia Brunel , Ismahane Belhabib , Yvan Martineau et al.
Journée scientifique de l’Association Française pour la Recherche sur le Cancer du Pancréas, Nov 2021, 2021-11-03, France
Communication dans un congrès hal-04834322 v1

FAK: targetable key regulator of stroma normalization

Ismahane Belhabib , Sonia Zaghdoudi , Corinne Bousquet , Christine Jean
Symposium “The tumor and its environment”, Dec 2021, Toulouse, France
Communication dans un congrès hal-04834333 v1

Impact de la mécanique sur le stroma dans le cas du cancer du pancréas

Lac Claire , Julie Foncy , Laurent Malaquin , Corinne Bousquet , Morgan Delarue et al.
Workshop "Matrice extracellulaire & Cancer", Sep 2020, Toulouse, France
Communication dans un congrès hal-04834102 v1

Targeting Cancer-Associated Fibroblast vulnerabilities in link with their secretory phenotype

Christophe Quemerais , Christine Jean , Sonia Zaghdoudi , Sauyeun Shin , Nelson Dusetti et al.
Club d'Etude des Cellules Epithéliales et Digestives, Mar 2019, Toulouse, France
Communication dans un congrès hal-04889019 v1

FAK activity within Cancer-associated fibroblasts: a key regulator of pancreatic ductal adenocarcinoma progression

Christine Jean
North West Cancer Research seminars, Jun 2019, Liverpool United Kingdom, United Kingdom
Communication dans un congrès hal-04834134 v1

Abstract 752: Genetic and pharmacological FAK inhibition disrupt a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth

Isabelle Tancioni , Sean Uryu , Florian Sulzmaier , Nina Shah , Christine Lawson et al.
105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Apr 2015, San diego (Californie), United States. pp.752-752, ⟨10.1158/1538-7445.AM2014-752⟩
Communication dans un congrès hal-04823741 v1

Dialogue between pancreatic tumor and adjacent tissue: a relationship under pressure

Claire Lac , Julie Foncy , Laurent Malaquin , Morgan Delarue , Corinne Bousquet et al.
Micro-physiological models: From organoids to organs-on-chip, Sep 2024, Cargèse, France. 2024
Poster de conférence hal-04834165 v1

Do mechanical forces induce a protumoral dialogue between the tumor and the adjacent healthy tissue?

Lac Claire , Julie Foncy , Corinne Bousquet , Morgan Delarue , Christine Jean
European Pancreatic Congress, Jun 2023, Alpbach, Austria. 2023
Poster de conférence hal-04834743 v1

Vicious circle between tumor and pancreatic adjacent tissue : the implication of solid stress

Lac Claire , Julie Foncy , Corinne Bousquet , Morgan Delarue , Christine Jean
1st Young Scientist Cancer Congress (YS2C), Oct 2023, Toulouse, France. 2023
Poster de conférence hal-04834747 v1

FAK activity in cancer-associated fibroblasts impacts vascularization in pancreatic cancer

Ismahane Belhabib , Sonia Zaghdoudi , Corinne Bousquet , Christine Jean
XXXVIème réunion du Club Français du Pancréas, Sep 2022, Paris, France
Poster de conférence hal-04834257 v1

3D device to decipher the impact of tumoral compressive solid stress on adjacent tissue

Claire Lac , Julie Foncy , Morgan Delarue , Christine Jean
MICROPHYSIOLOGICAL SYSTEMS from organoids to organ-on-chip, Apr 2022, Cargese, France. 2022
Poster de conférence hal-04834735 v1

3D device to decipher the impact of tumoral compressive solid stress on adjacent tissue

Claire Lac , Julie Foncy , Morgan Delarue , Corinne Bousquet , Christine Jean
Translationnelles Cancer Pancréatique GSO, Dec 2022, Toulouse, France. 2022
Poster de conférence hal-04834739 v1

FAK activity in cancer-associated fibroblasts impacts vascularization in pancreatic cancer

Ismahane Belhabib , Sonia Zaghdoudi , Corinne Bousquet , Christine Jean
XXXVème réunion du Club Français du Pancréas, Sep 2021, Lyon, France
Poster de conférence hal-04834232 v1

FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer

Ismahane Belhabib , Sonia Zaghdoudi , Corinne Bousquet , Christine Jean
16èmes Journées Annuelles du Cancéropôle GSO, Nov 2020, La gande Motte, France
Poster de conférence hal-04834268 v1

Fibroblastic FAK controls pancreatic cancer metastasis by enhancing extracellular matrix remodeling

Sonia Zaghdoudi , Emilie Decaup , Rémi Samain , Stéphanie Cassant-Sourdy , Julia Rochotte et al.
Pancreatic Cancer Symposium, Oct 2019, Toulouse, France
Poster de conférence hal-04834211 v1

Abstract A04: Endothelial FAK activity controls vascular permeability and tumor metastasis

Christine Jean , Xiao Lei Chen , Isabelle Tancioni , Sean Uryu , Christine Lawson et al.
AACR Special Conference on Cellular Heterogeneity in the Tumor Microenvironment, Feb 2014, San diego (Californie), United States. 75 (1_Supplement), pp.A04-A04, 2015, ⟨10.1158/1538-7445.CHTME14-A04⟩
Poster de conférence hal-04823911 v1

Do mechanical forces induce a protumoural dialogue between the tumour and the adjacent healthy tissue?

Claire Lac , Julie Foncy , Corinne Bousquet , Laurent Malaquin , Morgan Delarue et al.
Pancreatology, 2023, 23, pp.e23. ⟨10.1016/j.pan.2023.06.460⟩
Article dans une revue hal-04729109 v1

Pancreatic cancer orthotopic graft in a murine model

Milena Muzzolini , Ismahane Belhabib , Victoire Cardot , Annemilaï Tijeras-Raballand , Cindy Neuzillet et al.
Acta Cirurgica Brasileira, 2023, 38, pp.e382823. ⟨10.1590/acb382823⟩
Article dans une revue hal-04823516 v1

Extracellular Matrices and Cancer-Associated Fibroblasts: Targets for Cancer Diagnosis and Therapy?

Ismahane Belhabib , Sonia Zaghdoudi , Claire Lac , Corinne Bousquet , Christine Jean
Cancers, 2021, 13 (14), pp.3466. ⟨10.3390/cancers13143466⟩
Article dans une revue hal-04858465 v1

Extracellular Matrices and Cancer-Associated Fibroblasts: Targets for Cancer Diagnosis and Therapy?

Ismahane Belhabib , Sonia Zaghdoudi , Claire Lac , Corinne Bousquet , Christine Jean
Cancers, 2021, 13 (14), pp.3466. ⟨10.3390/cancers13143466⟩
Article dans une revue hal-04823522 v1
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Pharmacologic Normalization of Pancreatic Cancer-Associated Fibroblast Secretome Impairs Prometastatic Cross-Talk With Macrophages

Rémi Samain , Alexia Brunel , Thibaut Douché , Marjorie Fanjul , Stéphanie Cassant-Sourdy et al.
Cellular and Molecular Gastroenterology and Hepatology, 2021, 11 (5), pp.1405-1436. ⟨10.1016/j.jcmgh.2021.01.008⟩
Article dans une revue pasteur-03252986 v1

Phosphorylation of the MNK1 substrate eIF4E is not required for response to acute pancreatitis

Amandine Alard , Manon Strehaïano , David Müller , Charline Lasfargues , Stéphanie Cassant-Sourdy et al.
Pancreatology, 2021, 21 (4), pp.677-681. ⟨10.1016/j.pan.2021.02.013⟩
Article dans une revue hal-04823535 v1

FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer

Sonia Zaghdoudi , Emilie Decaup , Ismahane Belhabib , Rémi Samain , Stéphanie Cassant-Sourdy et al.
EMBO Molecular Medicine, 2020, 12 (11), ⟨10.15252/emmm.202012010⟩
Article dans une revue hal-03032260 v1
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Translatome-based classification reveals a dual metabolic dependency of a new tumor subtype of pancreatic cancer

Sauyeun Shin , Remy Nicolle , Christine Jean , Rémi Samain , Mira Ayadi et al.
BioRxiv, 2020, 12 (11), pp.1447-1454.e4. ⟨10.1101/2020.12.23.424227⟩
Article dans une revue hal-04858439 v1

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

Carlos Diaz Osterman , Duygu Ozmadenci , Elizabeth Kleinschmidt , Kristin Taylor , Allison Barrie et al.
eLife, 2019, 8 (21), ⟨10.7554/eLife.47327⟩
Article dans une revue hal-04823560 v1
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eIF4A inhibition circumvents uncontrolled DNA replication mediated by 4E-BP1 loss in pancreatic cancer

David Müller , Sauyeun Shin , Théo Goullet de Rugy , Rémi Samain , Romain Baer et al.
JCI Insight, 2019, 4 (21), ⟨10.1172/jci.insight.121951⟩
Article dans une revue hal-04821467 v1
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Differential Regulation of the Three Eukaryotic mRNA Translation Initiation Factor (eIF) 4Gs by the Proteasome

Amandine Alard , Catherine Marboeuf , Bertrand Fabre , Christine Jean , Yvan Martineau et al.
Frontiers in Genetics, 2019, 10 (254), pp.254. ⟨10.3389/fgene.2019.00254⟩
Article dans une revue hal-02169469 v1

Reversing pancreatic cancer metastasis through pharmacological targeting of pancreatic stellate cell's dialog with M2 macrophages

Rémi Samain , Julia Rochotte , Stéphanie Cassant-Sourdy , Aurélie Perraud , Muriel Mathonnet et al.
Pancreatology, 2018, 18 (4), pp.S91-S92. ⟨10.1016/j.pan.2018.05.248⟩
Article dans une revue hal-02421338 v1

Reversing pancreatic cancer immunosuppression through pharmacological targeting of activated pancreatic stellate cells

Corinne Bousquet , Rémi Samain , Julia Rochotte , Stéphanie Cassant-Sourdy , Herbert Schmid et al.
Pancreatology, 2017, 17 (3), pp.S44-S45. ⟨10.1016/j.pan.2017.05.139⟩
Article dans une revue hal-02421424 v1

Focal Adhesion Kinase: A promising therapeutic target in pancreatic adenocarcinoma

Emilie Decaup , Julia Rochotte , Stéphane Pyronnet , Corinne Bousquet , Christine Jean
Clinics and Research in Hepatology and Gastroenterology, 2017, 41 (3), pp.246-248. ⟨10.1016/j.clinre.2016.10.010⟩
Article dans une revue hal-04823565 v1
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Anti-metastatic potential of somatostatin analog SOM230: Indirect pharmacological targeting of pancreatic cancer-associated fibroblasts

Siham Moatassim-Billah , Camille Duluc , Rémi Samain , Christine Jean , Aurélie Perraud et al.
Oncotarget, 2016, 7 (27), pp.41584-41598. ⟨10.18632/oncotarget.9296⟩
Article dans une revue hal-02421440 v1

FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth

Isabelle Tancioni , Nichol Miller , Sean Uryu , Christine Lawson , Christine Jean et al.
Breast Cancer Research, 2015, 17 (1), pp.47. ⟨10.1186/s13058-015-0551-x⟩
Article dans une revue hal-04823573 v1

FAK Inhibition Disrupts a β5 Integrin Signaling Axis Controlling Anchorage-Independent Ovarian Carcinoma Growth

Isabelle Tancioni , Sean Uryu , Florian Sulzmaier , Nina Shah , Christine Lawson et al.
Molecular Cancer Therapeutics, 2014, 13 (8), pp.2050-2061. ⟨10.1158/1535-7163.MCT-13-1063⟩
Article dans une revue hal-04823581 v1

FAK in cancer: mechanistic findings and clinical applications

Florian Sulzmaier , Christine Jean , David Schlaepfer
Nature Reviews Cancer, 2014, 14 (9), pp.598-610. ⟨10.1038/nrc3792⟩
Article dans une revue hal-04823576 v1
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Cell growth in aggregates determines gene expression, proliferation, survival, chemoresistance, and sensitivity to immune effectors in follicular lymphoma.

Pauline Gravelle , Christine Jean , Julien Familiades , Emilie Decaup , Amandine Blanc et al.
American Journal of Pathology, 2014, 184 (1), pp.282-95. ⟨10.1016/j.ajpath.2013.09.018⟩
Article dans une revue inserm-00905913 v1

Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer

Nina Shah , Isabelle Tancioni , Kristy Ward , Christine Lawson , Xiao Lei Chen et al.
Gynecologic Oncology, 2014, 134 (1), pp.104-111. ⟨10.1016/j.ygyno.2014.04.044⟩
Article dans une revue hal-04823583 v1

Innate predisposition to immune escape in follicular lymphoma cells

Pauline Gravelle , Christine Jean , Wilfried Valleron , Guy Laurent , Jean-Jacques Fournié
OncoImmunology, 2014, 1 (4), pp.555-556. ⟨10.4161/onci.19365⟩
Article dans une revue hal-04823596 v1

Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

Christine Jean , Xiao Lei Chen , Ju-Ock Nam , Isabelle Tancioni , Sean Uryu et al.
Journal of Cell Biology, 2014, 204 (2), pp.247-263. ⟨10.1083/jcb.201307067⟩
Article dans une revue hal-04823587 v1

Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression

Kristy Ward , Isabelle Tancioni , Christine Lawson , Nichol Miller , Christine Jean et al.
Clinical and Experimental Metastasis, 2012, 30 (5), pp.579-594. ⟨10.1007/s10585-012-9562-5⟩
Article dans une revue hal-04823592 v1

VEGF-Induced Vascular Permeability Is Mediated by FAK

Xiao Lei Chen , Ju-Ock Nam , Christine Jean , Christine Lawson , Colin Walsh et al.
Developmental Cell, 2012, 22 (1), pp.146-157. ⟨10.1016/j.devcel.2011.11.002⟩
Article dans une revue hal-04823601 v1

UVA ‐activated synthesis of metalloproteinases 1, 3 and 9 is prevented by a broad‐spectrum sunscreen

Christine Jean , Patrick Bogdanowicz , Marie-José Haure , Nathalie Castex-Rizzi , Jean-Jacques Fournié et al.
Photodermatology, Photoimmunology & Photomedicine, 2011, 27 (6), pp.318-324. ⟨10.1111/j.1600-0781.2011.00627.x⟩
Article dans une revue istex hal-04823604 v1
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PGE inhibits Natural Killer and γδ T cell cytotoxicity triggered by NKR and TCR through a cAMP-mediated PKA type I-dependent signaling

Ludovic Martinet , Christine Jean , Gilles Dietrich , Jean-Jacques Fournié , Rémy Poupot
Biochemical Pharmacology, 2010, 80 (6), pp.838. ⟨10.1016/j.bcp.2010.05.002⟩
Article dans une revue hal-00608915 v1

Emerging Concepts for the Treatment of Hematological Malignancies with Therapeutic Monoclonal Antibodies

Aude-Hélène Capietto , Samarh Keirallah , Emilie Gross , Nicolas Dauguet , Emilie Laprevotte et al.
Current Drug Targets, 2010, 11 (7), pp.790-800. ⟨10.2174/138945010791320845⟩
Article dans une revue hal-02348959 v1

Epidermal Growth Factor Receptor/β-Catenin/T-Cell Factor 4/Matrix Metalloproteinase 1: A New Pathway for Regulating Keratinocyte Invasiveness after UVA Irradiation

Christine Jean , Amandine Blanc , Naïs Prade-Houdellier , Loïc Ysebaert , Hélène Hernandez-Pigeon et al.
Cancer Research, 2009, 69 (8), pp.3291-3299. ⟨10.1158/0008-5472.CAN-08-1909⟩
Article dans une revue hal-04784655 v1

UVA Induces Granzyme B in Human Keratinocytes through MIF

Hélène Hernandez-Pigeon , Christine Jean , Alexandra Charruyer , Marie-José Haure , Caroline Baudouin et al.
Journal of Biological Chemistry, 2007, 282 (11), pp.8157-8164. ⟨10.1074/jbc.M607436200⟩
Article dans une revue hal-02349000 v1

Epidermal Growth Factor Receptor Pathway Mitigates UVA-Induced G2/M Arrest in Keratinocyte Cells

Christine Jean , Hélène Hernandez-Pigeon , Amandine Blanc , Marie Charveron , Guy Laurent
Journal of Investigative Dermatology, 2007, 127 (10), pp.2418-2424. ⟨10.1038/sj.jid.5700863⟩
Article dans une revue hal-04823608 v1
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PKCzeta protects against UV-C-induced apoptosis by inhibiting acid sphingomyelinase-dependent ceramide production

Alexandra Charruyer , Christine Jean , Audrey Colomba , Jean-Pierre Jaffrézou , Anne Quillet-Mary et al.
Biochemical Journal, 2007, 405 (1), pp.77-83. ⟨10.1042/BJ20061528⟩
Article dans une revue hal-00478682 v1

Granzyme B induction signalling pathway in acute myeloid leukemia cell lines stimulated by Tumor Necrosis Factor alpha and Fas Ligand

Fabien Guilloton , Christine Jean , Aurélie de Thonel , Guy Laurent , Anne Quillet-Mary
Cellular Signalling, 2007, 19 (6), pp.1132-1140. ⟨10.1016/j.cellsig.2006.12.005⟩
Article dans une revue istex hal-02348993 v1

Human Keratinocytes Acquire Cellular Cytotoxicity under UV-B Irradiation

Hélène Hernandez-Pigeon , Christine Jean , Alexandra Charruyer , Marie-José Haure , Matthias Titeux et al.
Journal of Biological Chemistry, 2006, 281 (19), pp.13525-13532. ⟨10.1074/jbc.M512694200⟩
Article dans une revue hal-02349007 v1

TNFα stimulates NKG2D-mediated lytic activity of acute myeloid leukemic cells

F Guilloton , A. de Thonel , C Jean , C. Demur , V Mansat-de Mas et al.
Leukemia, 2005, 19 (12), pp.2206-2214. ⟨10.1038/sj.leu.2403952⟩
Article dans une revue hal-02349023 v1

TNFα Stimulates NKG2D-Mediated Lytic Activity of Acute Myeloid Leukemic Cells.

Guy Laurent , Fabien Guilloton , Aurélie de Thonel , Christine Jean , Cécile Demur et al.
Blood, 2005, 106 (11), pp.4411-4411. ⟨10.1182/blood.V106.11.4411.4411⟩
Article dans une revue hal-02349049 v1

Role of protein kinase C ζ isoform in Fas resistance of immature myeloid KG1a leukemic cells

Aurélie de Thonel , Ali Bettaïeb , Christine Jean , Guy Laurent , Anne Quillet-Mary
Blood, 2001, 98 (13), pp.3770-3777. ⟨10.1182/blood.V98.13.3770⟩
Article dans une revue hal-02349126 v1