christine Bezombes

55
Documents

Présentation


Publications

Publications

Image document

Goodbye flat lymphoma biology

Carla Faria , Cèlia Dobaño‐lópez , Patricia Pérez‐galán , Christine Bezombes
FEBS Letters, 2025, ⟨10.1002/1873-3468.70114⟩
Article dans une revue inserm-05247410 v1
Image document

Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target

Cèlia Dobaño-López , Juan García Valero , Ferran Araujo-Ayala , Ferran Nadeu , Fabien Gava et al.
Blood Cancer Journal, 2024, 14 (1), pp.75. ⟨10.1038/s41408-024-01041-7⟩
Article dans une revue inserm-04773418 v1
Image document

Patient-derived lymphoma spheroids integrating immune tumor microenvironment as preclinical follicular lymphoma models for personalized medicine

Carla Faria , Fabien Gava , Pauline Gravelle , Juan Garcia Valero , Celia Dobaño-López et al.
Journal for Immunotherapy of Cancer, 2023, 11 (10), pp.e007156. ⟨10.1136/jitc-2023-007156⟩
Article dans une revue inserm-04777458 v1

3D Model Characterization by 2D and 3D Imaging in t(14;18)-Positive B-NHL: Perspectives for In Vitro Drug Screens in Follicular Lymphoma

Fabien Gava , Carla Faria , Pauline Gravelle , Juan Valero , Cèlia Dobaño-López et al.
Cancers, 2021, 13 (7), pp.1490. ⟨10.3390/cancers13071490⟩
Article dans une revue hal-03365508 v1
Image document

Immunotherapies in Non-Hodgkin’s Lymphoma

Christine Bezombes , Patricia Pérez-Galán
Cancers, 2021, 13 (14), pp.3625. ⟨10.3390/cancers13143625⟩
Article dans une revue inserm-04783622 v1

Baseline SUVmax is related to tumor cell proliferation and patient outcome in follicular lymphoma

Cédric Rossi , Marie Tosolini , Pauline Gravelle , Sarah Pericart , Salim Kanoun et al.
Article dans une revue hal-03365480 v1
Image document

Monte Carlo dosimetry of a realistic multicellular model of follicular lymphoma in a context of radioimmunotherapy

Julien Bordes , Sébastien Incerti , Erick Mora‐ramirez , Jonathan Tranel , Cédric Rossi et al.
Med.Phys., 2020, mp.14370. ⟨10.1002/mp.14370⟩
Article dans une revue hal-02981284 v1
Image document

A Tridimensional Model for NK Cell-Mediated ADCC of Follicular Lymphoma

Emilie Decaup , Cédric Rossi , Pauline Gravelle , Camille Laurent , Julie Bordenave et al.
Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.01943⟩
Article dans une revue hal-02347408 v1
Image document

Increasing Uptake of Silica Nanoparticles with Electroporation: From Cellular Characterization to Potential Applications

Erick Phonesouk , Séverine Lechevallier , Audrey Ferrand , Marie-Pierre Rols , Christine Bezombes et al.
Materials, 2019, Inorganic Nanoparticles for Targeted Therapy: Fabrication, Physical Properties, Biomedical Applications and Fate, 12 (1), pp.179. ⟨10.3390/ma12010179⟩
Article dans une revue hal-02061583 v1
Image document

Profiling Immune Escape in Hodgkin’s and Diffuse large B-Cell Lymphomas Using the Transcriptome and Immunostaining

Sarah Péricart , Marie Tosolini , Pauline Gravelle , Cédric Rossi , Alexandra Traverse-Glehen et al.
Cancers, 2018, 10 (11), pp.415. ⟨10.3390/cancers10110415⟩
Article dans une revue hal-01927888 v1
Image document

Boosting γδ T cell-mediated antibody-dependent cellular cytotoxicity by PD-1 blockade in follicular lymphoma

Cédric Rossi , Pauline Gravelle , Emilie Decaup , Julie Bordenave , Mary Poupot et al.
OncoImmunology, 2018, 8 (3), pp.1554175. ⟨10.1080/2162402x.2018.1554175⟩
Article dans une revue inserm-04820835 v2

Mechanisms of PD-1/PD-L1 expression and prognostic relevance in non-Hodgkin lymphoma: a summary of immunohistochemical studies

Pauline Gravelle , Barbara Burroni , Sarah Péricart , Cédric Rossi , Christine Bezombes et al.
Oncotarget, 2017, 8 (27), pp.44960-44975. ⟨10.18632/oncotarget.16680⟩
Article dans une revue inserm-04820866 v1

IL-33-expanded human Vγ9Vδ2 T cells have anti-lymphoma effect in a mouse tumor model

Caroline Duault , Delphine Bétous , Christine Bezombes , Stéphane Roga , Corinne Cayrol et al.
European Journal of Immunology, 2017, 47 (12), pp.2137-2141. ⟨10.1002/eji.201747093⟩
Article dans une revue inserm-02472191 v1

Radiolabelling rituximab with 99m Tc in three steps procedure

Charlotte Fontan , Christine Bezombes , Anne Sophie Salabert , Julien Costes , Raphael Lopez et al.
Journal of Labelled Compounds and Radiopharmaceuticals, 2015, 58 (7), pp.274-280. ⟨10.1002/jlcr.3283⟩
Article dans une revue istex inserm-04820894 v1
Image document

Cell growth in aggregates determines gene expression, proliferation, survival, chemoresistance, and sensitivity to immune effectors in follicular lymphoma.

Pauline Gravelle , Christine Jean , Julien Familiades , Emilie Decaup , Amandine Blanc et al.
American Journal of Pathology, 2014, 184 (1), pp.282-95. ⟨10.1016/j.ajpath.2013.09.018⟩
Article dans une revue inserm-00905913 v1

Phosphoantigens and butyrophilin 3A1 induce similar intracellular activation signaling in human TCRVγ9+ γδ T lymphocytes

Emilie Decaup , Caroline Duault , Christine Bezombes , Mary Poupot , Ariel Savina et al.
Immunology Letters, 2014, 161 (1), pp.133-137. ⟨10.1016/j.imlet.2014.05.011⟩
Article dans une revue istex inserm-02472223 v1
Image document

Anti-tumor activity of obinutuzumab and rituximab in a follicular lymphoma 3D model

E Decaup , C Jean , C Laurent , P Gravelle , S Fruchon et al.
Blood Cancer Journal, 2013, 3 (8), pp.e131. ⟨10.1038/bcj.2013.32⟩
Article dans une revue inserm-04820822 v1

What lessons can be learned from γδ T cell-based cancer immunotherapy trials?

Jean-Jacques Fournié , Helene Sicard , Mary Poupot , Christine Bezombes , Amandine Blanc et al.
Cellular and molecular immunology, 2013, 10 (1), pp.35-41. ⟨10.1038/cmi.2012.39⟩
Article dans une revue inserm-02472240 v1
Image document

Direct Effect of Rituximab in B-Cell–Derived Lymphoid Neoplasias: Mechanism, Regulation, and Perspectives

Christine Bezombes , Jean-Jacques Fournié , Guy Laurent
Molecular Cancer Research, 2011, 9 (11), pp.1435 - 1442. ⟨10.1158/1541-7786.mcr-11-0154⟩
Article dans une revue inserm-04820849 v1

Rituximab inhibits B-cell receptor signaling

Samar Kheirallah , Pierre Caron , Emilie Gross , Anne Quillet-Mary , Justine Bertrand-Michel et al.
Blood, 2010, 115 (5), pp.985-994. ⟨10.1182/blood-2009-08-237537⟩
Article dans une revue hal-02348969 v1

Emerging Concepts for the Treatment of Hematological Malignancies with Therapeutic Monoclonal Antibodies

Aude-Hélène Capietto , Samarh Keirallah , Emilie Gross , Nicolas Dauguet , Emilie Laprevotte et al.
Current Drug Targets, 2010, 11 (7), pp.790-800. ⟨10.2174/138945010791320845⟩
Article dans une revue hal-02348959 v1

Bromohydrin pyrophosphate enhances antibody-dependent cell-mediated cytotoxicity induced by therapeutic antibodies

Julie Gertner , Cecile Bonnafous , Christine Bezombes , Aude-Hélène Capietto , Virginie Scaglione et al.
Blood, 2009, 113 (20), pp.4875-4884. ⟨10.1182/blood-2008-08-172296⟩
Article dans une revue hal-02348974 v1
Image document

PKCzeta protects against UV-C-induced apoptosis by inhibiting acid sphingomyelinase-dependent ceramide production

Alexandra Charruyer , Christine Jean , Audrey Colomba , Jean-Pierre Jaffrézou , Anne Quillet-Mary et al.
Biochemical Journal, 2007, 405 (1), pp.77-83. ⟨10.1042/BJ20061528⟩
Article dans une revue hal-00478682 v1
Image document

UV-C Light Induces Raft-associated Acid Sphingomyelinase and JNK Activation and Translocation Independently on a Nuclear Signal

Alexandra Charruyer , Solène Grazide , Christine Bezombes , Sabina Müller , Guy Laurent et al.
Journal of Biological Chemistry, 2005, 280 (19), pp.19196-19204. ⟨10.1074/jbc.M412867200⟩
Article dans une revue inserm-04820879 v1

Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains

C. Bezombes
Blood, 2004, 104 (4), pp.1166-1173. ⟨10.1182/blood-2004-01-0277⟩
Article dans une revue hal-02349082 v1

Implication of Raft Microdomains in Drug Induced Apoptosis

Christine Bezombes , Guy Laurent , Jean-Pierre Jaffrezou
Current Medicinal Chemistry Anticancer Agents, 2003, 3 (4), pp.263-270. ⟨10.2174/1568011033482413⟩
Article dans une revue istex inserm-04820881 v1

Phosphatidylcholine‐derived phosphatidic acid and diacylglycerol are involved in the signaling pathways activated by docetaxel

Nicolas Maestre , Christine Bezombes , Isabelle Plo , Thierry Levade , François Lavelle et al.
Journal of Experimental Therapeutics and Oncology, 2003, 3 (1), pp.36-46. ⟨10.1046/j.1359-4117.2003.01065.x⟩
Article dans une revue istex inserm-04826850 v1

Protein kinase Cζ mediated Raf-1/extracellular-regulated kinase activation by daunorubicin

Véronique Mansat-De Mas , Hélène Hernandez , Isabelle Plo , Christine Bezombes , Nicolas Maestre et al.
Blood, 2003, 101 (4), pp.1543-1550. ⟨10.1182/blood-2002-05-1585⟩
Article dans une revue hal-02349095 v1

Overexpression of Protein Kinase Cζ Confers Protection Against Antileukemic Drugs by Inhibiting the Redox-Dependent Sphingomyelinase Activation

Christine Bezombes , Aurélie de Thonel , Andriana Apostolou , Thierry Louat , Jean-Pierre Jaffrézou et al.
Molecular Pharmacology, 2002, 62 (6), pp.1446-1455. ⟨10.1124/mol.62.6.1446⟩
Article dans une revue hal-03030310 v1

Ara‐C‐ and daunorubicin‐induced recruitment of Lyn in sphingomyelinase‐enriched membrane rafts

Solène Grazide , Nicolas Maestre , Robert Jan Veldman , Christine Bezombes , Stéphane Maddens et al.
FASEB Journal, 2002, 16 (12), pp.1685-1687. ⟨10.1096/fj.01-0794fje⟩
Article dans une revue inserm-04820869 v1

Overexpression of Protein Kinase Cζ Confers Protection Against Antileukemic Drugs by Inhibiting the Redox-Dependent Sphingomyelinase Activation

Christine Bezombes , Aurélie de Thonel , Andriana Apostolou , Thierry Louat , Jean-Pierre Jaffrézou et al.
Molecular Pharmacology, 2002, 62 (6), pp.1446-1455. ⟨10.1124/mol.62.6.1446⟩
Article dans une revue hal-02349104 v1

Oxidative stress-induced activation of Lyn recruits sphingomyelinase and is requisite for its stimulation by Ara-C

Christine Bezombes , Isabelle Plo , Véronique Mansat-de Mas , Anne Quillet-Mary , Anne Nègre-Salvayre et al.
FASEB Journal, 2001, 15 (9), pp.1583-1585. ⟨10.1096/fj.00-0787fje⟩
Article dans une revue hal-02349143 v1

Lysosomal sphingomyelinase is not solicited for apoptosis signaling

Christine Bezombes , Bruno Ségui , Olivier Cuvillier , Alain Bruno , Emmanuelle Uro-Coste et al.
FASEB Journal, 2000, 15 (2), pp.297-299. ⟨10.1096/fj.00-0466fje⟩
Article dans une revue inserm-04826847 v1

Implication of Radical Oxygen Species in Ceramide Generation, c-Jun N-Terminal Kinase Activation and Apoptosis Induced by Daunorubicin

Véronique Mansat-De Mas , Christine Bezombes , Anne Quillet-Mary , Ali Bettaïeb , Aurélie de Thonel D’orgeix et al.
Molecular Pharmacology, 1999, 56 (5), pp.867-874. ⟨10.1124/mol.56.5.867⟩
Article dans une revue hal-03028424 v1

Implication of Radical Oxygen Species in Ceramide Generation, c-Jun N-Terminal Kinase Activation and Apoptosis Induced by Daunorubicin

Véronique Mansat-De Mas , Christine Bezombes , Anne Quillet-Mary , Ali Bettaieb , Aurélie de Thonel D’orgeix et al.
Molecular Pharmacology, 1999, 56 (5), pp.867-874. ⟨10.1124/mol.56.5.867⟩
Article dans une revue hal-02349158 v1

Restoration of TNF-α-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833

Christine Bezombes , Nicolas Maestre , Guy Laurent , Thierry Levade , Ali Bettaïeb et al.
FASEB Journal, 1998, 12 (1), pp.101-109. ⟨10.1096/fasebj.12.1.101⟩
Article dans une revue inserm-04826845 v1
Image document

Multicellular Aggregates of Lymphoma Cells (MALC) and Patient-Derived Lymphoma Spheroids (PDLS) as 3D preclinical B-cell non-Hodgkin lymphoma models for personalized medicine

Carla Faria , Fabien Gava , C Dobano-Lopez , L Rimailho , S Quertinmont et al.
2nd Summer school: Micro-physiological models: From organoids to organ-on-chips., 2024, Cargese (Corse), France
Poster de conférence inserm-04827746 v1
Image document

Study of γδ T cells from healthy donors usable for immunotherapy screening in non-Hodgkins Lymphomas

L Rimailho , N Gower , F Gava , C Faria , P Gravelle et al.
International gamma delta T cell conference, Jun 2023, Lisbonne, Portugal
Poster de conférence inserm-04827776 v1
Image document

Identification of CD39 as a new therapeutic target in non-Hodgkin's lymphomas

L Rimailho , C Faria , F Gava , P Gravelle , M Tosolini et al.
Journées de l'Ecole Doctorale BSB 2023, 2023, Toulouse, France
Poster de conférence inserm-04827786 v1
Image document

Study of the efficacy of novel bispecific antibodies targeting immune checkpoints in a 3D model of B non-Hodgkin lymphoma.

N. Gower , F. Gava , L. Rimailho , C. Faria , Pauline Gravelle et al.
International Conference on Malignant Lymphoma, 2023, Lugano, Switzerland, Switzerland. 41 (S2), pp.287-288, 2023, ⟨10.1002/hon.3164_198⟩
Poster de conférence inserm-04830782 v1
Image document

Role of CD39 on gamma delta T cells as a positive marker of anti-CD20-induced ADCC of non-Hodgkins lymphoma cells

L Rimailho , N Gower , F Gava , C Faria , P Gravelle et al.
Cancéropole Grand sud Ouest GSO, journée annuelle, 2023, Arcachon, France
Poster de conférence inserm-04827759 v1
Image document

TAyloring LYmphoma therapy with Immune Escape Signatures from 3D avatars of B‐cell NHL

F. Gava , C. Faria , Pauline Gravelle , J. Garcia-Valero , C. Quelen et al.
International Conference on Malignant Lymphoma, 2023, Lugano, Switzerland, Switzerland. 41 (S2), pp.286-287, 2023, ⟨10.1002/hon.3164_197⟩
Poster de conférence inserm-04830807 v1
Image document

Multicellular Aggregates of Lymphoma Cells (MALC) and Patient-Derived Lymphoma Spheroids (PDLS) as 3D preclinical B-cell non-Hodgkin lymphoma models for personalized medicine

F Gava , C Faria , P Gravelle , J García-Valero , C Dobaño-López et al.
GSO modèles alternatifs à l’expérimentation animale, May 2023, Toulouse, France
Poster de conférence inserm-04827769 v1
Image document

TAyloring LYmphoma therapy with Immune Escape Signatures from 3D avatars of B-cell NHL (TALYIES).

Fabien Gava , Carla Faria , Pauline Gravelle , Juan Garcia-Valero , Cathy Quelen et al.
Summit Imcore 2022, Oct 2022, Amsterdam (NETHERLANDS), Netherlands. 197, pp.286-287
Poster de conférence inserm-04830884 v1
Image document

TAyloring LYmphoma therapy with Immune Escape Signatures from 3D avatars of sMZL (TALYIES)

F Gava , C Faria , Pauline Gravelle , Cathy Quelen , P Perez-Galan et al.
Imcore summit 2022, Oct 2022, Amsterdam (NETHERLANDS), Netherlands
Poster de conférence inserm-04830870 v1
Image document

Immunocompetent 3D Follicular Lymphoma Model: A Preclinical Tool to Design Tailored Immunotherapies

Cèlia Dobaño-López , Juan Valero , Ferran Araujo-Ayala , Ferran Nadeu , Fabien Gava et al.
64th ASH Annual Meeting and Exposition, Nov 2022, New Orleans (LA), United States. 140 (Supplement 1), pp.9279-9280, 2022, ⟨10.1182/blood-2022-166131⟩
Poster de conférence inserm-04830843 v1
Image document

3D Model Characterization by 2D and 3D Imaging in t(14;18)-Positive B-NHL: Perspectives for In Vitro Drug Screens in Follicular Lymphoma

Carla Faria , Fabien Gava , Pauline Gravelle , Juan Garcia Valero , Celia Dobaño-López et al.
EACR Imaging cancer virtual conferences: Imaging Cancer: Gaining insights from cells to organisms, Jun 2021, Virtual, France
Poster de conférence inserm-04831048 v1

Le SUVmax pré-thérapeutique est associé à la prolifération des cellules tumorales et non au micro-environnement immunitaire et prédit la survie sans progression des patients avec un lymphome folliculaire.

Cédric Rossi , S Kanoun , Marie Tosolini , Sarah Pericart , Julia Gilhodes et al.
Congrès de la Société Française d'Hématologie (SFH), 2019, Paris, France.
Poster de conférence inserm-04831138 v1
Image document

Le SUVmax pré-thérapeutique est associé à la prolifération des cellules tumorales et non au micro-environnement immunitaire et prédit la survie sans progression des patients avec un lymphome folliculaire

C Rossi , S Kanoun , Marie Tosolini , S Pericart , J Gilhodes et al.
SFH 2019 - 39e Société Française d'Hématologie, Mar 2019, Paris, France
Poster de conférence inserm-04827449 v1
Image document

Patient derived lymphoma spheroids

Carla Faria , Fabien Gava , Pauline Gravelle , Julie Bordenave , Chloé Laplagne et al.
Retraite scientifique du Centre de Recherches en Cancérologie de Toulouse, Sep 2019, France (FR), France
Poster de conférence inserm-04831113 v1
Image document

Organoids studies in Lymphoproliferative disorders.

Christine Bezombes
Roche webinar, Oct 2024, Webinar, France
Communication dans un congrès inserm-04820548 v1
Image document

Patient-Derived lymphoma spheroids integrating immune tumor micronevironment as preclinical follicular lymphoma models for personalized medicine.

C Faria , F Gava , P Gravelle , J Garcia-Valero , C Dobaño-López et al.
4 ème workshop « BioFabrication & Cancer » du Cancéropôle Grand Sud-Ouest., Cancéropôle Grand Sud-Ouest (GSO), Sep 2022, Bordeaux, France
Communication dans un congrès inserm-04827365 v1
Image document

New avatars for medical research.

Christine Bezombes
The 12th Summer School on Medicines, SSM12, Jul 2022, Toulouse, France
Communication dans un congrès inserm-04827378 v1
Image document

What lessons we learned on tumor microenvironment using non-Hodgkin's lymphoma 3D cultures?

Christine Bezombes
The tumor and its microenvironment symposium, Dec 2021, Toulouse, France
Communication dans un congrès inserm-04827381 v1
Image document

Patient Derived Lymphoma spheroids, a new pre-clinical model for Non-Hodgkin Lymphoma research

Carla Faria , C Bezombes
3rd Workshop « BioFabrication & Cancer », GSO, Sep 2019, Montpellier, France
Communication dans un congrès inserm-04827431 v1