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Christine Leroux

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Presentation

Christine Leroux (women, PhD, HDR) is a research director from INRAE, the French national institute for research in agriculture, nutrition and environment. After obtaining her PhD in Molecular Genetics (University of Orsay-Paris XI, France) in 1992, Christine started to work at INRA on milk components biosynthesis and secretion in dairy ruminants. She studies the effects of different factors (mainly genetics and nutritional) influencing mammary gland functioning during lactation. Christine’s research aims to improve nutritional quality of milk for consumers and to identify indicators of animal metabolism and health using strategies of nutrigenomics. She firstly studied the effects of genetics polymorphism on protein synthesis, and then she worked on effects of ruminant nutrition on mammary and in a lesser extent on adipose tissues gene expression associated with milk fat composition. More recently, she initiated studies on microRNA and their nutritional regulation in mammary gland. She was visiting researcher scientist at University of California Davis (2017-2019) where she investigated the potential role of milk microRNA as a food source bioactive and contributor to human health. End of 2020, she had 5383 citations and an h-index of 41 referenced by Google Scholar. She participated to 15 national and international research projects. She has 8 years of experience of management of research groups (more than 15 persons) and of a transcriptomic platform, and she has supervised over 26 students (both undergraduates and graduates).

Publications

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Comparison of goat and cow milk-derived extracellular vesicle miRNomes

Zuzana Krupova , Christine Leroux , Christine Péchoux , Claudia Bevilacqua , Patrice Martin
Scientific Data , 2023, 10 (1), pp.465. ⟨10.1038/s41597-023-02347-0⟩
Journal articles hal-04214068v1

MiRNome variations in milk fractions during feed restrictions of different intensities in dairy cows

Antoine Leduc , Sandrine Le Guillou , Denis Laloë , Lucile Herve , Johann Laubier
BMC Genomics, 2023, 24 (1), pp.680. ⟨10.1186/s12864-023-09769-5⟩
Journal articles hal-04284310v1
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Milk fat miRNome changes in response to LPS challenge in Holstein cows

Christine Leroux , Matteo Cuccato , Karol Pawłowski , Francesca Tiziana Cannizzo , Paola Sacchi
Veterinary Research, 2023, 54 (1), pp.111. ⟨10.1186/s13567-023-01231-4⟩
Journal articles hal-04328606v1

Comparative transcriptome analysis of goat (Capra hircus) adipose tissue reveals physiological regulation of body reserve recovery after the peak of lactation

Yannick Faulconnier , Céline Boby , Fanny Coulpier , Sophie Lemoine , Patrice Martin
Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 2022, 41, pp.100956. ⟨10.1016/j.cbd.2021.100956⟩
Journal articles hal-03524137v1
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Milk metabolites and fatty acids as noninvasive biomarkers of metabolic status and energy balance in early-lactation cows

José Pires , T. Larsen , Christine Leroux
Journal of Dairy Science, 2022, 105 (1), pp.201-220. ⟨10.3168/jds.2021-20465⟩
Journal articles hal-03424547v1

Milk fat globules as a source of microRNAs for mastitis detection

Christine Leroux , Karol Pawlowski , Pierre-Alexis Billa , José A.A. Pires , Yannick Faulconnier
Livestock Science, 2022, 263, pp.104997. ⟨10.1016/j.livsci.2022.104997⟩
Journal articles hal-03781656v1
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Milk proteins as a feed restriction signature indicating the metabolic adaptation of dairy cows

Antoine Leduc , S. Le Guillou , L. Bianchi , L. Oliveira Correia , M. Gelé
Scientific Reports, 2022, 12 (1), pp.18886. ⟨10.1038/s41598-022-21804-1⟩
Journal articles hal-03860146v1

Nutritional Regulation of Mammary Gland Development and Milk Synthesis in Animal Models and Dairy Species

Cathy Hue-Beauvais , Yannick Faulconnier , Madia Charlier , Christine Leroux
Genes, 2021, 12 (4), pp.523. ⟨10.3390/genes12040523⟩
Journal articles hal-03223225v1
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Nutrigenomic analyses reveal miRNAs and mRNAs affected by feed restriction in the mammary gland of midlactation dairy cows

Pierre-Alexis Billa , Yannick Faulconnier , Tao Ye , Céline Bourdon , José Pires
PLoS ONE, 2021, 16 (4), ⟨10.1371/journal.pone.0248680⟩
Journal articles hal-03200342v1

Perspective: Milk microRNAs as Important Players in Infant Physiology and Development

Christine Leroux , Mathilde Chervet , Bruce German
Advances in Nutrition, 2021, 12 (5), pp.1625-1635. ⟨10.1093/advances/nmab059⟩
Journal articles hal-03234311v1
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Milk metabolites as noninvasive indicators of nutritional status of mid-lactation Holstein and Montbéliarde cows

Pierre-Alexis Billa , Yannick Faulconnier , Torben Larsen , Christine Leroux , José Pires
Journal of Dairy Science, 2020, 103 (4), pp.3133-3146. ⟨10.3168/jds.2019-17466⟩
Journal articles hal-02624734v1
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L’épigénétique et la construction du phénotype chez le bovin

Nathalie Beaujean , Marion Boutinaud , Eve Devinoy , Hélène Jammes , Sandrine Le Guillou
INRAE Productions Animales, 2020, 33 (2), pp.109-124. ⟨10.20870/productions-animales.2020.33.2.4477⟩
Journal articles hal-02947903v1

Different miRNA contents between mammary epithelial cells and milk fat globules: a random or a targeted process?

Karol Pawlowski , Daiane Lago-Novais , Claudia Bevilacqua , Lenha Mobuchon , Nicolas Crapart
Molecular Biology Reports, 2020, 47 (10), pp.8259-8264. ⟨10.1007/s11033-020-05787-8⟩
Journal articles hal-03151812v1
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Undernutrition modified metabolic responses to intramammary lipopolysaccharide but had limited effects on selected inflammation indicators in early-lactation cows

José Pires , Karol Pawlowski , Jacques Rouel , Carole Delavaud , Gilles Foucras
Journal of Dairy Science, 2019, 102 (6), pp.5347-5360. ⟨10.3168/jds.2018-15446⟩
Journal articles hal-02620566v1
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Mammary gland transcriptome and proteome modifications by nutrient restriction in early lactation Holstein cows challenged with intramammary lipopolysaccharide

Karol Pawlowski , José Pires , Yannick Faulconnier , Christophe Chambon , Pierre Germon
International Journal of Molecular Sciences, 2019, 20 (5), 19 p. ⟨10.3390/ijms20051156⟩
Journal articles hal-02625031v1
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Defects of the endoplasmic reticulum and changes to lipid droplet size in mammary epithelial cells due to miR-30b-5p overexpression are correlated to a reduction in Atlastin 2 expression

Sandrine Le Guillou , Johann Laubier , Christine Longin , Etienne Aujean , Johan Castille
Biochemical and Biophysical Research Communications, 2019, 512 (2), pp.283-288. ⟨10.1016/j.bbrc.2019.03.022⟩
Journal articles hal-02627428v1
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Deep RNA-Seq reveals miRNome differences in mammary tissue of lactating Holstein and Montbéliarde cows

Pierre-Alexis Billa , Yannick Faulconnier , T. Ye , M. Chervet , Fabienne Le Provost
BMC Genomics, 2019, 20, pp.621
Journal articles hal-02620652v1
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Effects of Azgp1-/- on mammary gland, adipose tissue and liver gene expression and milk lipid composition in lactating mice

Yannick Faulconnier , Céline Boby , José Pires , Cyril Labonne , Christine Leroux
Gene, 2019, 692, pp.201-207. ⟨10.1016/j.gene.2019.01.010⟩
Journal articles hal-02627788v1

Extruded linseed alone or in combination with fish oil modifies mammary gene expression profiles in lactating goats

Yannick Faulconnier , Laurence Bernard , Céline Boby , Jordann Domagalski , Yves Chilliard
Animal, 2018, 12 (8), pp.1564-1575. ⟨10.1017/S1751731117002816⟩
Journal articles hal-02622050v1
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Sunflower oil supplementation affects the expression of miR-20a-5p and miR-142-5p in the lactating bovine mammary gland

Lenha Mobuchon , Sandrine Le Guillou , Sylvain Marthey , Johann Laubier , Denis Laloë
PLoS ONE, 2017, 12 (12), pp.e0185511. ⟨10.1371/journal.pone.0185511⟩
Journal articles hal-02617650v1

Bovine mammary nutrigenomics and changes in the milk composition due to rapeseed or sunflower oil supplementation of high-forage or high-concentrate diets

Christine Leroux , Laurence Bernard , Yannick Faulconnier , Jacques J. Rouel , Anne de La Foye
Journal of Nutrigenetics and Nutrigenomics, 2016, 9 (2-4), pp.65-82. ⟨10.1159/000445996⟩
Journal articles hal-02640940v1

Milk fatty acid composition and mammary lipogenic genes expression in bovine cloned and control cattle

Laurence Bernard , Christophe Richard , Valerie Gelin , Christine Leroux , Yvan Heyman
Livestock Science, 2015, 176, pp.188-195. ⟨10.1016/j.livsci.2015.03.016⟩
Journal articles hal-02640576v1

Dietary sunflower oil modulates milk fatty acid composition without major changes in adipose and mammary tissue fatty acid profile or related gene mRNA abundance in sheep

T. Castro-Carrera , P. Frutos , Christine Leroux , Yves Y. Chilliard , G. Hervás
Animal, 2015, 9 (4), pp.582-591. ⟨10.1017/S1751731114002882⟩
Journal articles hal-02636182v1
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Annotation of the goat genome using next generation sequencing of microRNA expressed by the lactating mammary gland: comparison of three approaches

Lenha Mobuchon , Sylvain Marthey , Mekki Boussaha , Sandrine Le Guillou , Christine Leroux
BMC Genomics, 2015, 16, pp.285. ⟨10.1186/s12864-015-1471-y⟩
Journal articles hal-01194123v1

Effect of extruded linseeds alone or in combination with fish oil on intake, milk production, plasma metabolite concentrations and milk fatty acid composition in lactating goats

Laurence Bernard , Christine Leroux , Jacques J. Rouel , Carole Delavaud , Kevin John Shingfield
Animal, 2015, 9 (5), pp.810-821. ⟨10.1017/S1751731114003048⟩
Journal articles hal-02631935v1
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Food deprivation affects the miRNome in the lactating goat mammary gland

Lenha Mobuchon , Sylvain S. Marthey , Sandrine Le Guillou , Denis Laloë , Fabienne Le Provost
PLoS ONE, 2015, 10 (10), 20 p. ⟨10.1371/journal.pone.0140111⟩
Journal articles hal-02630964v1
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Characterisation and comparison of lactating mouse and bovine mammary gland miRNomes

Sandrine Le Guillou , Sylvain Marthey , Denis Laloë , Johann Laubier , Lenha Mobuchon
PLoS ONE, 2014, 9 (3), pp.e91938. ⟨10.1371/journal.pone.0091938⟩
Journal articles hal-01193833v1

Effects of diet and physiological factors on milk fat synthesis, milk fat composition and lipolysis in the goat: A short review

Yves Y. Chilliard , Pablo Gutierrez Toral , Kevin John Shingfield , Jacques J. Rouel , Christine Leroux
Small Ruminant Research, 2014, 122 (1-3), pp.31-37. ⟨10.1016/j.smallrumres.2014.07.014⟩
Journal articles hal-02639525v1
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Dietary flavanols modulate the transcription of genes associated with cardiovascular pathology without changes in their DNA methylation state

Dragan Milenkovic , Wim Vanden Berghe , Céline Boby , Christine Leroux , K. Declerc
PLoS ONE, 2014, 9 (4), pp.e95527. ⟨10.1371/journal.pone.0095527⟩
Journal articles hal-02634108v1
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La fonction de lactation : régulation de la biosynthèse des constituants du lait

Christine Leroux , Laurence Bernard , Frederic Dessauge , Fabienne Le Provost , Patrice Martin
INRA Productions Animales, 2013, 26 (2), pp.117-128
Journal articles hal-01019559v1

Effects of fish oil and additional starch on tissue fatty acid profile and lipogenic gene mRNA abundance in lactating goats fed a diet containing sunflower-seed oil

Pablo Gutierrez Toral , Laurence Bernard , Carole Delavaud , Dominique Gruffat , Christine Leroux
Animal, 2013, 7 (6), pp.948-956. ⟨10.1017/S1751731113000049⟩
Journal articles hal-02643437v1

Long-chain fatty acids differentially alter lipogenesis in bovine and caprine mammary slices

Laurence Bernard , Mohammed Bagher M. B. Montazer Torbati , Benoit Graulet , Christine Leroux , Yves Y. Chilliard
Journal of Dairy Research, 2013, 80 (1), pp.89-95. ⟨10.1017/S0022029912000726⟩
Journal articles hal-02643537v1
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Numéro spécial "La vache et le lait". Avant Propos

Philippe Faverdin , Christine Leroux
INRA Productions Animales, 2013, 26 (2), pp.71-76
Journal articles hal-01210610v1

Infrared spectroscopic methods for the discrimination of cow milk according to the feeding systems, cow breed and altitude of the dairy farms

Bernardo B. Valenti , Bruno Martin , Donato Andueza , Christine Leroux , Cyril C. Labonne
International Dairy Journal, 2013, 32 (1), pp.26-32. ⟨10.1016/j.idairyj.2013.02.014⟩
Journal articles hal-01000927v1

Prediction of the goat milk fatty acids by near infrared reflectance spectroscopy

Donato Andueza , Jacques J. Rouel , Yves Y. Chilliard , Christine Leroux , Anne Ferlay
European Journal of Lipid Science and Technology, 2013, 115 (6), pp.612 - 620. ⟨10.1002/ejlt.201200315⟩
Journal articles hal-02649107v1
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Nutritional regulation of mammary lipogenesis and milk fat in ruminant: contribution to sustainable milk production

Laurence Bernard , Christine Leroux , Yves Y. Chilliard
Revista Colombiana de Ciencias Pecuarias, 2013, 26, pp.292-302
Journal articles hal-02642036v1

Selection of reference genes for quantitative real-time PCR normalisation in adipose tissue, muscle, liver and mammary gland from ruminants

Muriel Bonnet , Laurence Bernard , Sébastien Bes , Christine Leroux
Animal, 2013, 7 (8), pp.1344-1353. ⟨10.1017/S1751731113000475⟩
Journal articles hal-02645011v1
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Effect of the level and type of starchy concentrate on tissue lipid metabolism, gene expression and milk fatty acid secretion in Alpine goats receiving a diet rich in sunflower-seed oil

Laurence Bernard , Christine Leroux , Jacques J. Rouel , Muriel Bonnet , Yves Y. Chilliard
British Journal of Nutrition, 2012, 107 (8), pp.1147-1159. ⟨10.1017/S0007114511004181⟩
Journal articles hal-02648706v1

Effects of polyunsaturated fatty acids from plant oils and algae on milk fat yield and composition are associated with mammary lipogenic and SREBF1 gene expression

Joaquin Angulo , Liliana Mahecha , Karin Nuernberg , Gerd Nuernberg , Dirk Dannenberger
Animal, 2012, 6 (12), pp.1961-1972. ⟨10.1017/S1751731112000845⟩
Journal articles hal-02652522v1

The Transcriptomic profiles of adipose tissues are modified by feed deprivation in lactating goats

Yannick Faulconnier , Yves Y. Chilliard , Mohammed Bagher M. B. Montazer Torbati , Christine Leroux
Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 2011, 6 (2), pp.139-149. ⟨10.1016/j.cbd.2010.12.002⟩
Journal articles hal-02648271v1

Prediction of milk fatty acid composition by near infrared reflectance spectroscopy

Mauro Coppa , Anne Ferlay , Christine Leroux , Michel Jestin , Yves Y. Chilliard
International Dairy Journal, 2010, 20 (3), pp.182-189. ⟨10.1016/j.idairyj.2009.11.003⟩
Journal articles hal-02659184v1

La nutrigénomique

Christine Leroux , Isabelle Cassar-Malek
Agro Mag, 2010, 18
Journal articles hal-02659035v1
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Perspectives offertes par les approches en «omique» pour l’amélioration de la durabilité de l’élevage des herbivores

Jean-François J.-F. Hocquette , Hamid Boudra , Isabelle Cassar-Malek , Christine Leroux , Brigitte B. Picard
INRA Productions Animales, 2009, 22 (5), pp.385-396
Journal articles hal-02662984v1

Effect of sunflower-seed oil and linseed oil on tissue lipid metabolism, gene expression, and milk fatty acid secretion in Alpine goats fed maize silage–based diets

Laurence Bernard , Muriel Bonnet , Christine Leroux , Kevin John Shingfield , Yves Y. Chilliard
Journal of Dairy Science, 2009, 92 (12), pp.6083-6094. ⟨10.3168/jds.2009-2048⟩
Journal articles hal-02657889v1

Whole intact rapeseeds or sunflower oil in high-forage or high-concentrate diets affects milk yield, milk composition, and mammary gene expression profile in goats

Severine Ollier , Christine Leroux , Anne de La Foye , Laurence Bernard , Jacques J. Rouel
Journal of Dairy Science, 2009, 92 (11), pp.5544-5560. ⟨10.3168/jds.2009-2022⟩
Journal articles hal-02665026v1

Goat's alpha(S1)-casein polymorphism affects gene expression profile of lactating mammary gland

Severine Ollier , Stéphanie Chauvet , Patrice Martin , Yves Y. Chilliard , Christine Leroux
Animal, 2008, 2 (4), pp.566-573. ⟨10.1017/S1751731108001584⟩
Journal articles hal-02662192v1

Image analysis and data normalization procedures are crucial for microarray analyses

Ali Kpatcha Kadanga , Christine Leroux , Muriel Bonnet , Stéphanie Chauvet , Bruno Meunier
Gene Regulation and Systems Biology, 2008, 2, pp.107-112
Journal articles hal-02654575v1

Adipocyte fatty acid-binding protein and mitochondrial enzyme activities in muscles as relevant indicators of marbling in cattle

Catherine C. Jurie , Isabelle Cassar-Malek , Muriel Bonnet , Christine Leroux , Dominique Bauchart
Journal of Animal Science, 2007, 85 (10), pp.2660-2669
Journal articles hal-02656889v1

Mammary transcriptome analysis of food-deprived lactating goats highlights genes involved in milk secretion and programmed cell death 1,2

Severine Ollier , Christèle Robert-Granié , Laurence Bernard , Yves Y. Chilliard , Christine Leroux
Journal of Nutrition, 2007, 137, pp.560-567
Journal articles hal-02657141v1

Food-deprived lactating goats highlights genes involved in milk secretion and programmed cell death.

S. Ollier , Christèle Robert-Granié , Laurence Bernard , Yves Chilliard , Christine Leroux
Journal of Nutrition, 2007, 137, pp.1-8
Journal articles hal-02656471v1

Glucose-6-phosphate dehydrogenase and leptin are related to marbling differences among Limousin and Angus or Japanese Black x Angus steers

Muriel Bonnet , Yannick Faulconnier , Christine Leroux , Catherine C. Jurie , Isabelle Cassar-Malek
Journal of Animal Science, 2007, 85 (11), pp.2882-2894
Journal articles hal-02653399v1

Goat's alpha-s1 casein genotype influences its milk fatty acid composition and delta-9 desaturation ratios

Yves Y. Chilliard , Jacques J. Rouel , Christine Leroux
Animal Feed Science and Technology, 2006, 131 (3-4), pp.474-487
Journal articles hal-02663227v1

Mammary lipid metabolism and milk fatty acid secretion in alpine goasts fed vegetable lipids

Laurence Bernard , Jacques Rouel , Christine Leroux , Anne Ferlay , Yannick Faulconnier
Journal of Dairy Science, 2005, 88 (4), pp.1478-1482. ⟨10.3168/jds.S0022-0302(05)72816-2⟩
Journal articles hal-02680222v1

A collection of bovine cDNA probes for gene expression profiling in muscle

K. Sudre , Christine Leroux , Isabelle Cassar-Malek , Jean-François J.-F. Hocquette , Patrice Martin
Molecular and Cellular Probes, 2005, 19 (1), pp.61-70. ⟨10.1016/j.mcp.2004.07.005⟩
Journal articles hal-02678442v1

A cDNA macroarray resource for gene expression profiling in ruminant tissues involved in reproduction and production (milk and beef) traits

Carine Bernard , Severine S. Degrelle , Severine Ollier , Evelyne E. Campion , Isabelle Cassar-Malek
Journal of Physiology and Pharmacology, 2005, 56 (suppl 3), pp.215-224
Journal articles hal-02677050v1

Biochemical and transcriptomic analyses of two bovine skeletal muscles in Charolais bulls divergently selected for muscle growth

Séverine Sudre , Isabelle Cassar-Malek , Anne Listrat , Yasuko Ueda , Christine Leroux
Meat Science, 2005, 70 (2), pp.267-277
Journal articles hal-02676737v1

Expression and nutritional regulation of lipogenic genes in mammary gland and adipose tissues of lactating goats

Laurence Bernard , Christine Leroux , Muriel Bonnet , Jacques Rouel , Patrice Martin
Journal of Dairy Research, 2005, 72, pp.250-255. ⟨10.1017/S0022029905000786⟩
Journal articles hal-02682974v1

Proteomic tools to characterize the protein fraction of Equidae milk

Guy Miranda , M.F. Mahé , Christine Leroux , Patrice Martin
Proteomics, 2004, 4, pp.2496-2509
Journal articles hal-02675241v1

Nutritional status induces divergent variations of GLUT4 protein content, but not lipoprotein lipase activity, between adipose tissues and muscles in adult cattle

Muriel Bonnet , Yannick Faulconnier , Jean-François J.-F. Hocquette , Francois Bocquier , Christine Leroux
British Journal of Nutrition, 2004, 92 (4), pp.617-625. ⟨10.1079/BJN20041240⟩
Journal articles hal-02680426v1

Transcriptome analysis of two bovine muscles during ontogenesis

Karine Sudre , Christine Leroux , Geneviève Pietu , Isabelle Cassar-Malek , Anne Listrat
Journal of Biochemistry, 2003, 133 (6), pp.745-756. ⟨10.1093/jb/mvg096⟩
Journal articles hal-02682738v1
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Real-time RT-PCR and cDNA macroarray to study the impact of the genetic polymorphism at the $\alpha_{s1}$-casein locus on the expression of genes in the goat mammary gland during lactation

Christine Leroux , Fabienne Le Provost , Elisabeth Petit , Laurence Bernard , Yves Chilliard
Reproduction Nutrition Development, 2003, 43 (5), pp.459-469. ⟨10.1051/rnd:2003032⟩
Journal articles hal-00900521v1

Qtl detection and candidate gene study for traits related to food quality and safety in sheep (meat and dairy) production within the framework of a European research contract called "genesheepsafety"

Francis F. Barillet , Loys L. Bodin , Philippe Chemineau , Yves Y. Chilliard , Edmond Cribiu
Options Méditerranéennes. Série A : Séminaires Méditerranéens, 2003, 55, pp.13-17
Journal articles hal-02676053v1

Fatty acid composition of sheep milk from a backcross Sarda x Lacaune resource population: Preliminary QTL detection for CLA content

A. Carta , G. Piredda , M. Addis , Andrea Cabiddu , M. Fiori
Options Méditerranéennes. Série A : Séminaires Méditerranéens, 2003, 55, pp.107-113
Journal articles hal-02673054v1
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A specific pattern of splicing for the horse $\alpha$S1-Casein mRNA and partial genomic characterization of the relevant locus

Dragan Milenkovic , Patrice Martin , Gérard Guérin , Christine Leroux
Genetics Selection Evolution, 2002, 34 (4), pp.509-519. ⟨10.1051/gse:2002020⟩
Journal articles hal-00894424v1
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Mammary leptin synthesis, milk leptin and their putative physiological roles

Muriel Bonnet , Carole Delavaud , Karine Laud , Isabelle Gourdou , Christine Leroux
Reproduction Nutrition Development, 2002, 42 (5), pp.399-413. ⟨10.1051/rnd:2002034⟩
Journal articles hal-00900336v1

Interallelic recombination is probably responsible for the occurence of a new alphaS1-casein variant found in the goat species

Claudia Bevilacqua , Pasquale Ferranti , G. Garro , Cristina Veltri , R. Lagonigro
European Journal of Biochemistry, 2002, 269, pp.1293-1303
Journal articles hal-02674081v1

Genetic diversity of the two main Moroccan goat breeds: phylogenetic relationships with four breeds reared in France

A. Tadlaoui Ouafi , Jean-Marc Babilliot , Christine Leroux , Patrice Martin
Small Ruminant Research, 2002, 45, pp.225-233
Journal articles hal-02672706v1
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The impact of genetic polymorphisms on the protein composition of ruminant milks

Patrice Martin , Małgorzata Szymanowska , Lech Zwierzchowski , Christine Leroux
Reproduction Nutrition Development, 2002, 42 (5), pp.433-459. ⟨10.1051/rnd:2002036⟩
Journal articles hal-00900338v1
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A specific pattern of splicing for the horse αS1-Casein mRNA and partial genomic characterization of the relevant locus

Dragan Milenkovic , Patrice Martin , Gérard Guérin , Christine Leroux
Genetics Selection Evolution, 2002, 34 (4), pp.509-519
Journal articles hal-02670100v1

Mammary leptin synthesis, milk leptin and their putative physiological roles

Muriel Bonnet , Carole Delavaud , K. Laud , Isabelle Gourdou , Christine Leroux
Reproduction Nutrition Development, 2002, 42, pp.399-413
Journal articles hal-02672237v1

Leptin expression in the ovine mammary gland : putative sequential involvement of adipose, epithelial and myoepithelial cells during pregnancy and lactation

Muriel Bonnet , Isabelle Gourdou , Christine Leroux , Yves Y. Chilliard , Jean Djiane
Journal of Animal Science, 2002, 80, pp.723-728
Journal articles hal-02669993v1

The impact of genetic polymorphisms on the protein composition of ruminant milks

Patrice Martin , M. Szymanowska , L. Zwierzchowski , Christine Leroux
Reproduction Nutrition Development, 2002, 42, pp.433-459
Journal articles hal-02679211v1

Etude du transcriptome du muscle pour l'identification de gènes déterminant les caractéristiques musculaires et les qualités sensorielles de la viande bovine.

K. Sudre , Isabelle Cassar-Malek , Christine Leroux , Anne Listrat , Catherine Jurie
La revue française de la recherche en viandes et produits carnés, 2002, pp.111-112
Journal articles hal-02669486v1

Leptin in ruminants. Gene expression in adipose tissue and mammary gland, and regulation of plasma concentration

Yves Chilliard , Muriel Bonnet , Carole Delavaud , Yannick Faulconnier , Christine Leroux
Domestic Animal Endocrinology, 2001, 21 (4), pp.271-295
Journal articles hal-02670107v1

Characterization of the caprine stearoyl-CoA desaturase gene and its mRNA showing an unusually long 3' -UTR sequence arising from a single exon

Laurence Bernard , Christine Leroux , Hélène Hayes , M. Gautier , Yves Chilliard
Gene, 2001, 281, pp.53-61
Journal articles hal-02672941v1

A fluorescent reverse transcription-polymerase chain reaction assay to quantify the lipoprotein lipase messenger RNA

Muriel Bonnet , Christine Leroux , Yves Chilliard , Patrice Martin
Molecular and Cellular Probes, 2001, 15, pp.187-194
Journal articles hal-02671939v1

Effects of photoperiod and feeding level on adipose tissue and muscle lipoprotein lipase activity and mRNA level in dry non-pregnant sheep

Yannick Faulconnier , Muriel Bonnet , Francois Bocquier , Christine Leroux , Yves Chilliard
British Journal of Nutrition, 2001, 85 (3), pp.299-306
Journal articles hal-02671384v1

Characterization of the caprine stearoyl-CoA desaturase gene and its mRNA showing an unusually long 3'-UTR sequence arising from a single exon

Laurence Bernard , Christine Leroux , Hélène Hayes , Mathieu Gautier , Yves Chilliard
Gene, 2001, 281 (1-2), pp.53-61. ⟨10.1016/S0378-1119(01)00822-8⟩
Journal articles hal-02683444v1
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La génomique fonctionnelle de la glande mammaire des ruminants

Fabienne Le Provost , Christine Leroux , Patrice Martin
Productions Animales, 2000, HS 2000, pp.171-173
Journal articles hal-02684397v1

Nucleotide sequence of the ovine lipoprotein lipase cDNA

Muriel Bonnet , Christine Leroux , Patrice Martin
Journal of Animal Science, 2000, 78, pp.2994-2995
Journal articles hal-02685863v1
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Le gène caprin spécifiant la caséine αs1 : un suspect tout désigné aux effets aussi multiples qu’inattendus

Patrice Martin , Christine Leroux
Productions Animales, 2000, HS 2000, pp.125-132
Journal articles hal-02694040v1

Lipoprotein lipase activity and mRNA are up-regulated by refeeding in adipose tissue and cardiac muscle of sheep

Muriel Bonnet , Christine Leroux , Yannick Faulconnier , Jean-François J.-F. Hocquette , Francois Bocquier
Journal of Nutrition, 2000, 130, pp.749-756
Journal articles hal-02694885v1
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La fonction du gène : les grandes étapes de l'utilisation de l'information génétique

Christine Leroux , Gwenola Tosser-Klopp
Productions Animales, 2000, HS 2000, pp.21-28
Journal articles hal-02696477v1
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Fréquences alléliques des caséines chez les chèvres des Pyrénées. Cas particulier de la caséine β nulle

G. Ricordeau , M.F. Mahé , Marie-Annick Persuy , Christine Leroux , V. François
Productions Animales, 1999, 12 (1), pp.29-38
Journal articles hal-02698577v1
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Régulation du métabolisme lipidique des tissus adipeux et musculaires chez le ruminant. Effets du niveau alimentaire et de la photopériode

Yannick Faulconnier , Muriel Bonnet , Francois Bocquier , Christine Leroux , Jean-François J.-F. Hocquette
Productions Animales, 1999, 12 (4), pp.287-300
Journal articles hal-02694594v1

Messenger RNAs encoding lipoprotein lipase, fatty acid synthase and hormone-sensitive lipase in the adipose tissue of underfed-refed ewes and cows

Muriel Bonnet , Yannick Faulconnier , Jean-François J.-F. Hocquette , Christine Leroux , Dominique Langin
Reproduction Nutrition Development, 1998, 38 (3), pp.297-307
Journal articles hal-02698559v1

Genotyping of alpha-s1 casein in sheep.

F. Pilla , Claudia Bevilacqua , Christine Leroux , A. Fraghi , Patrice Martin
Animal Genetics, 1998, 29, pp.472-473
Journal articles hal-02694324v1
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Messenger RNAs encoding lipoprotein lipase, fatty acid synthase and hormone-sensitive lipase in the adipose tissue of underfed-refed ewes and cows

Muriel Bonnet , Yannick Faulconnier , Jeanne Fléchet , Jean-François J.-F. Hocquette , Christine Leroux
Reproduction Nutrition Development, 1998, 38 (3), pp.297-307
Journal articles hal-00900209v1

Real time PCR quantitation of mRNA encoding key enzymes of lipogenesis. Application to LPL assay in ovine adipose tissue.

M. Bonnet , Christine Leroux , Corinne Giraud-Delville , Yves Chilliard , Patrice Martin
Animal Genetics, 1998, suppl. 1, pp.53
Journal articles hal-02684991v1

Isolation and molecular characterization of bovine Rhesus-like transcripts and chromosome mapping of the relevant locus

L. Méténier-Delisse , Hélène Hayes , Christine Leroux , Corinne Giraud-Delville , Hubert Levéziel
Animal Genetics, 1997, 28, pp.202-209
Journal articles hal-02687945v1

Differential splicing of pre-messenger RNA produces multiple forms of mature caprine alphas1-casein

Pasquale Ferranti , F. Addeo , A. Malorni , L. Chianese , Christine Leroux
European Journal of Biochemistry, 1997, 249, pp.1-7
Journal articles hal-02690763v1

Study of lipoprotein lipase mRNAs in ovine adipose tissue by quantitative fluorescence polymerase chain reaction

Muriel Bonnet , Christine Leroux , J.P. Furet , Patrice Martin , Fabienne Le Provost
Reproduction Nutrition Development, 1997, 37 (3), pp.371
Journal articles hal-02685426v1

mRNAs encoding lipogenic and lipolytic enzymes in the adipose tissue of underfed-refed ewes and cows

M. Bonnet , Yannick Faulconnier , Jean-François J.-F. Hocquette , Christine Leroux , Dominique Langin
International Journal of Obesity, 1996, 20 (Suppl4), pp.148
Journal articles hal-02684856v1

The gene encoding alpha s1 -casein is expressed in human mammary epithelial cells during lactation

Patrice Martin , G. Brignon , J.P. Furet , Christine Leroux
Lait, 1996, 76, pp.525-537
Journal articles hal-02691902v1

Quantitative fluorescence PCR assay for studing the expression of the gene encoding lipoprotein lipase in ovine adipose tissue

M. Bonnet , Christine Leroux , J.P. Furet , Fabienne Le Provost , Yannick Faulconnier
Animal Genetics, 1996, 27 (Suppl2), pp.87
Journal articles hal-02685736v1

Isolation and molecular characterization of bovine Rhesus-like transcripts and chromosome mapping of the relevant locus.

L. Méténier-Delisse , Andre A. Eggen , Hélène Hayes , Christine Leroux , Corinne Giraud-Delville
Animal Genetics, 1996, suppl. 2, pp.95
Journal articles hal-02693204v1

The caprine alphaS1- and bêta-casein genes are 12-kb apart and convergently transcribed

Christine Leroux , Patrice Martin
Animal Genetics, 1996, 27 (Suppl-2), pp.93
Journal articles hal-02684919v1

Molecular diversity of the goat alpha-S1-casein gene: impact on casein content and cheesemaking properties

Patrice Martin , Christine Leroux , Yves Amigues , M. Jansà Pérez , Florent Remeuf
Bulletin International Dairy Federation, 1995, 304, pp.12-13
Journal articles hal-02704607v1

Occurence of a LINE sequence in the 3' UTR of the goat alpha-s1-casein E-encoding allele associated with reduced protein synthesis level

M.J. Perez , Christine Leroux , A.S. Bonastre , Patrice Martin
Gene, 1994, 147, pp.179-187
Journal articles hal-02700191v1

A microsatellite within the bovine kappa-casein gene reveals a polymorphism correlating strongly with polymorphisms previously described at the protein as well as the DNA level

Hubert Levéziel , C. Rodellar , Christine Leroux , L. Pépin , Cécile Grohs
Animal Genetics, 1994, 25 (4), pp.223-228
Journal articles hal-02708503v1

Prolactin gene expression in ovine and caprine mammary gland

Fabienne Le Provost , Christine Leroux , Patrice Martin , P. Gaye , Jean Djiane
Neuroendocrinology, 1994, 60, pp.305-313
Journal articles hal-02705067v1

Exon-skipping is responsible for the 9 amino acid residue deletion occuring near the N-terminal of human beta-casein

Patrice Martin , Christine Leroux
Biochemical and Biophysical Research Communications, 1992, 183, pp.750-757
Journal articles hal-02701201v1
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Mutations away from splice site recognition sequences might cis-modulate alternative splicing of goat alpha S1-casein transcripts

Christine Leroux , Nathalie Mazure , Patrice Martin
Journal of Biological Chemistry, 1992, 267 (9), pp.6147-6157
Journal articles hal-02709720v1

Restriction fragment length polymorphism identification of goat alpha s1 casein alleles : a potential tool in selection of individuals carrying alleles associated with a high level of protein synthesis

Christine Leroux , Patrice Martin , M.F. Mahé , Hubert Levéziel , J.C. Mercier
Animal Genetics, 1990, 21, pp.341-351
Journal articles hal-02711886v1

Integration and germ line transmission of foreign genes microinjected into fertilized trout eggs

René R. Guyomard , Daniel Chourrout , Christine Leroux , Louis L. Houdebine , F. Pourrain
Biochimie, 1989, 71, pp.857-863
Journal articles hal-02721230v1
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Validation of HappyMoo MIR energy balance models on external datasets with feeding restriction

M Calmels , J Pires , M Boutinaud , Antoine Leduc , C Leroux
74. Annual meeting of the european federation of animal science (EAAP), EAAP, Aug 2023, Lyon, France. pp.1029
Conference papers hal-04195776v1
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Characterization of milk small extracellular vesicles to study adaptation to lactation in ruminants

C Boby , A Delavaud , J Pires , L E Monfoulet , S Bes
74th Annual Meeting of the European Federation of Animal Science, Aug 2023, Lyon, France. ⟨10.3920/978-90-8686-936-7⟩
Conference papers hal-04195798v1

La composition en microARN du lait sous influence des races bovines

Sandrine Le Guillou , Ouleye Sidibe , Antoine Leduc , Johann Laubier , Yannick Faulconnier
Journées Scientifiques du Département Génétique Animale (JSGA), Département Génétique Animale, INRAE, Sep 2022, Bordeaux, France
Conference papers hal-04227375v1
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Les exosomes : des véhicules de signatures moléculaires pour comprendre le dialogue entre les organes des ruminants

Céline Boby , José Pires , Arnaud Delavaud , Laurent-Emmanuel Monfoulet , Laurence Bernard
1. Rencontres Clermontoises sur les Vésicules Extracellulaires, Laurent-Emmanuel MONFOULET-INRAE-UNH (Organisateur), Feb 2022, Clermont-Ferrand, France. ⟨10.17180/ev22-co02⟩
Conference papers hal-03561304v1

Feed restriction affects protein and microRNA levels in dairy cows' milk

Antoine Leduc , Sandrine Le Guillou , L Bianchi , M. Gelé , Lucile Herve
72. Annual meeting of the european federation of animal science (EAAP), Aug 2021, Davos, Switzerland. pp.620
Conference papers hal-03318595v1
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Les métabolites et les acides gras du lait : des indicateurs non invasifs du statut métabolique et du bilan énergétique chez les vaches laitières

José Pires , Pierre-Alexis Billa , Torben Larsen , Yannick Faulconnier , Christine Leroux
Résumés - Réunion virtuelle Glande mammaire lait / Galactinnov, INRAE, Animation transversale Phase Galactinov, Nov 2021, en ligne, France
Conference papers hal-03958170v1

Impact d’une restriction alimentaire sur les miRNome et protéome du lait chez la vache laitière

Antoine Leduc , Sandrine Le Guillou , L. Bianchi , Lydie Oliveira Correia , Andrea Rau
Glande mammaire lait / Galactinnov, Nov 2021, En ligne, France
Conference papers hal-03747713v1
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Examples of current research on indicators of adaptative response in periparturient dairy ruminants

Carole Delavaud , José Pires , Mylène Delosière , Christine Leroux , Muriel Bonnet
Cycle de conférences 'Global Health', Jan 2020, Clermont-Ferrand, France
Conference papers hal-02503309v1

MiRNA profile in milk extracellular vesicles is modulated by caprine alphaS1-casein genotype

Christine Leroux , M. Chervet , Zuzana Krupova , Claudia Bevilacqua , Yannick Faulconnier
8. IDF International Symposium on Sheep, goat and other non-cow milk, Nov 2020, Inconnue, Belgium
Conference papers hal-03155018v1

Omics approach to characterize milk-derived extracellular vesicles/exosomes isolated from goats expressing or not alphas1-CN

Zuzana Krupova , Christine Péchoux , Celine Henry , Sylvia Sanquer , Anne-Claire Boschat
Extracellular vesicles in Health & disease-FSEV-2019, Oct 2019, Nantes, France
Conference papers hal-03160259v1

Des biomarqueurs aux outils de prédiction des performances des ruminants et de la qualité de leurs produits

Brigitte Picard , Laurence Bernard , Isabelle Cassar-Malek , Carole Delavaud , Mylène Delosière
Journées d’Animation Scientifique (JAS) du Département Physiologie Animale et Systèmes d'Elevage, Apr 2018, Rennes, France
Conference papers hal-02940696v1
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Les métabolites du lait comme indicateurs non invasifs du statut nutritionnel chez les vaches Holstein et Montbéliarde en milieu de lactation

Pierre-Alexis Billa , Yannick Faulconnier , Torben Larsen , Christine Leroux , José Pires
24. Rencontres autour des Recherches sur les Ruminants (3R), Dec 2018, Paris, France
Conference papers hal-02734722v1

Milk metabolites as noninvasive indicators of physiological state and energy balance of early lactation cows

José Pires , Christine Leroux , Torben Larsen
10. International Symposium on the Nutrition of Herbivores (ISNH10), Sep 2018, Clermont-Ferrand, France
Conference papers hal-02738279v1

Influence of caprine alphaS1-casein genotype on milk exosomal miRNAs

Mathilde Chervet , Zuzana Krupova , Claudia Bevilacqua , Bruce German , Christine Leroux
International Milk Genomics Consortium IMGC, Nov 2018, Sacramento, United States
Conference papers hal-02734577v1

Une approche intégrée pour comprendre le dialogue entre tissus/organes chez les ruminants producteurs

Isabelle Cassar-Malek , Mylène Delosière , Laurence Bernard , Céline Boby , Carole Delavaud
Journées d’Animation Scientifique (JAS) du Département Physiologie Animale et Systèmes d'Elevage, Apr 2018, Rennes, France
Conference papers hal-02940675v1

Signatures épigénétiques associées à l’état physiologique, nutritionnel et pathologique chez la vache laitière en postpartum

Maxime Gasselin , Marion Boutinaud , Laura Notebaert , Jean-Philippe Perrier , François Piumi
3. Journée de Séminaires du Département Phase sur l'Epigénétique EpiPhase, May 2017, Jouy-en-Josas, France. 1 p
Conference papers hal-01605492v1

Paroles de psychologues auprès de patients sans parole

Emmanuelle Truong-Minh , Gaëlle Gili , Julie Chailley , Christine Leroux
Entretiens de la Psychologie, FFPP- Fédération Française des Psychologues et de Psychologie, Oct 2017, Lille, France
Conference papers hal-02378713v1

Impact des microARNs sur la lactation et la régulation nutritionnelle de leur expression dans la glande mammaire

Lenha Mobuchon , Sandrine Le Guillou , Sylvain S. Marthey , Johann J. Laubier , Mekki Boussaha
2. Réunion d'Animation épiPHASE, Institut National de Recherche Agronomique (INRA). UAR Département Physiologie Animale et Systèmes d'Elevage (0558)., Mar 2016, Saint-Pée-sur-Nivelle, France
Conference papers hal-02795094v1

Milk fat globules as a source of mammary microRNA

Karol Pawlowski , Daiane Lago Novais , José Pires , Lenha Mobuchon , Yannick Faulconnier
International Symposium on Microgenomics 2016, Jun 2016, Paris, France
Conference papers hal-02743285v1
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Exploiting the knowledge about model species and humans to revisit the biology of livestock animals

Isabelle Cassar-Malek , Brigitte B. Picard , Alain Boissy , Christine Leroux , Lenha Mobuchon
Workshop of translational biology in Agriculture and Medecine ‘From Bench to Bed in Medecine and from Pot to Plot in Agriculture', Institut National de Recherche Agronomique (INRA). UMR Génétique Diversité et Ecophysiologie des Céréales (1095)., Oct 2014, Aubière, France. 1 p
Conference papers hal-02799064v1

Characterisation and comparison of lactating mouse and bovine mammary gland miRNomes

Sandrine Le Guillou , Sylvain Marthey , Denis Laloë , Johann Laubier , Lenha Mobuchon
Gordon Research Conference on Mammary Gland Biology, Jun 2014, Lucca, Italy. 1 p
Conference papers hal-01193894v1
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Caractérisation de l’aptitude à coagulation du lait des vaches Salers et identification d’un variant rare de la caséine kappa

Leonardo Bianchi , Bruno Martin , Adeline Védrine , Christine Leroux , Eloi Haudebourg
21. Rencontres autour des Recherches sur les Ruminants, Dec 2014, Paris, France
Conference papers hal-01194034v1

Nutritional regulation of microRNAs in the lactating goat mammary gland

Lenha Mobuchon , Sylvain Marthey , Sandrine Le Guillou , Denis Laloë , Christine Leroux
Gordon Research Conference on Mammary Gland Biology, Jun 2014, Lucca, Italy
Conference papers hal-01193908v1
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Species comparison of lactating mammary gland miRNomes: to the identification of conserved lactation-related microRNA

Sandrine Le Guillou , Sylvain S. Marthey , Denis Laloë , Johann J. Laubier , Jordann J. Domagalski
12th International Meeting - Cellular aspects of mRNA fate, Université Pierre et Marie Curie - Paris 6 (UPMC). FRA., Jun 2013, Paris, France. pp.1
Conference papers hal-01001041v1

Regulacion nutricional de la expresion de los genes implicados en la lipogenesis en ovejas alimentadas con aceite de girasol. 1. Tejido secretor mamario

Pablo Gutierrez Toral , T. Castro-Carrera , Laurence Bernard , G. Hervás , Christine Leroux
15. Jornadas sobre Produccion Animal, May 2013, Zaragoza, España. pp.210-212
Conference papers hal-02747345v1
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MilkChEST, an integrative approach of the secretion pathways in the mammary epithelial cell: molecular dissection of milk fat adaptability

Christine Leroux , Christian Beauvallet , Laurence Bernard , Claudia Bevilacqua , Frédéric Bouvier
European Regional Conference On Goats, Jun 2013, Tromsø, Norway
Conference papers hal-01194090v1
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Feeding different lipid supplements through lactation in dairy goats: 1) effects on energy balance and milk production

M. Eknaes , H. Volden , K. Hove , Ra. Inglingstad , Laurence Bernard
European Regional Conference On Goats, Jun 2013, Tromso, Norway. 2 p
Conference papers hal-02744993v1
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Effects of feeding and physiological factors on goat milk fatty acid secretion and milk fat lipolysis

Yves Y. Chilliard , Pablo Gutierrez Toral , J Shingfield , Jacques J. Rouel , Christine Leroux
European Regional Conference On Goats, Jun 2013, Tromso, Norway. 3 p
Conference papers hal-02746500v1
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Nutritional regulation of mammary lipogenesis and milk fat in ruminant: contribution to sustainable milk production

Laurence Bernard , Christine Leroux , Yves Y. Chilliard
12. Encuentro Nacional y 5. Internacional de los Investigadores de las Ciencias Pecuarias: ENICIP, 2013, Medellin, Colombia
Conference papers hal-02805781v1

Regulacion nutricional de la expresion de los genes implicados en la lipogenesis en ovejas alimentadas con aceite de girasol. 2. Tejidos adiposos subcutaneo y perirrenal

Pablo Gutierrez Toral , T. Castro-Carrera , Christine Leroux , G. Hervás , Laurence Bernard
15. Jornadas sobre Produccion Animal, Zaragoza 14 y 15 de mayo de 2013., May 2013, Saragosse, España. pp.213-215
Conference papers hal-02747675v1

Etat des recherches nutrigénomiques chez les ruminants

Christine Leroux
Journee Nutrigenomique - UNCEIA, Valorial et Alltech, Nov 2010, Ploufragan, France. n. p
Conference papers hal-02813895v1