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Christoph Grunau

Director IHPE
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Presentation

The goal of our group is to elucidate the multiple relations between environment, organisms and their fitness in the lab and in the field, in order to understand and control host-symbiont/parasite interactions. We see inheritance in a broad sense including genetic, epigenetic, cytoplasmic, and holobiont elements. My specialty is **evolutionary epigenetics**. Education *Sep 2011 – Sep 2011* **Université de Perpignan** HDR, Epigenetics Perpignan, France *Jan 1995 – Dec 1999* **IMB Jena** PhD, Epigenetics Jena, Thuringia, Germany *Sep 1994 – Dec 1995* **RIKEN** PreDoc, Microbiology Wako, Japan *Sep 1988 – Aug 1994* **Friedrich-Schiller-University Jena** Diploma, Biology Jena, Germany Research Experience *Jan 2021– present *Sep 2013 – present* **Director of IHPE (UMR5244)** **Professor (Full)** Université de Perpignan, Laboratory of Host-Pathogen-Environnement Interactions (IHPE) Perpignan, France *Sep 2007 – Aug 2013* **Professor (Assistant)** Université de Perpignan, Laboratory of Ecology and Evolution of Interactions 2EI Perpignan, France *Sep 2006 – Aug 2007* **PostDoc Position** Université de Perpignan, Perpignan, France *Jan 2000 – Mar 2005* **PostDoc Position** French National Centre for Scientific Research, Institut de Génétique Humaine Montpellier, Languedoc-Roussillon, France *Jan 1996 – Dec 1999* **PhD Student** Institute of Molecular Biotechnology, Jena, Jena, Thuringia, Germany *Oct 1994 – Dec 1995* **PreDoc** RIKEN, Intestinal Microbe Symbiosis Research Laboratory Wako, Saitama, Japan *Sep 1993 – Aug 1994* **Master** Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany

Publications

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Hit-and-Run Epigenetic Editing for Vectors of Snail-Borne Parasitic Diseases

Nelia Luviano , David Duval , Wannaporn Ittiprasert , Jean-Francois Allienne , Geneviève Tavernier et al.
Frontiers in Cell and Developmental Biology, 2022, 10, pp.794650. ⟨10.3389/fcell.2022.794650⟩
Journal articles hal-03608918v1
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Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection

Manon Fallet , Caroline Montagnani , Bruno Petton , Julien Lorgeril , Sébastien Comarmond et al.
Microbiome, 2022, 10, pp.85. ⟨10.1186/s40168-022-01280-5⟩
Journal articles hal-03635473v2
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Automated ChIPmentation procedure on limited biological material of the human blood fluke Schistosoma mansoni

Chrystelle Lasica , Ronaldo de Carvalho Augusto , Hélène Moné , Gabriel Mouahid , Cristian Chaparro et al.
Wellcome Open Research, 2022, 7, pp.133. ⟨10.12688/wellcomeopenres.17779.1⟩
Journal articles hal-03255320v2
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The tropical coral Pocillopora acuta displays an unusual chromatin structure and shows histone H3 clipping plasticity upon bleaching

David Roquis , Céline Cosseau , Kelly Brener Raffalli , Pascal Romans , Patrick Masanet et al.
Wellcome Open Research, 2022, 6, pp.195. ⟨10.12688/wellcomeopenres.17058.2⟩
Journal articles hal-03315093v2
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Getting out of crises: Environmental, social-ecological and evolutionary research is needed to avoid future risks of pandemics

Delphine Destoumieux-Garzón , Franziska Matthies-Wiesler , Nicolas Bierne , Aurélie Binot , Jérôme Boissier et al.
Environment International, 2022, 158, 12 p. ⟨10.1016/j.envint.2021.106915⟩
Journal articles hal-03428100v1
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The insecticide permethrin induces transgenerational behavioral changes linked to transcriptomic and epigenetic alterations in zebrafish (Danio rerio)

Mélanie Blanc , Philipp Antczak , Xavier Cousin , Christoph Grunau , Nikolai Scherbak et al.
Science of the Total Environment, 2021, 779, pp.146404. ⟨10.1016/j.scitotenv.2021.146404⟩
Journal articles hal-03175988v1
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Chromatin landscape dynamics in the early development of the plant parasitic nematode Meloidogyne incognita

Rahim Hassanaly-Goulamhoussen , Ronaldo de Carvalho Augusto , Nathalie Marteu-Garello , Arthur Péré , Bruno Favery et al.
Frontiers in Cell and Developmental Biology, 2021, 9, pp.765690. ⟨10.1101/2021.05.11.443567⟩
Journal articles hal-03467409v1
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Phenotypic response to light versus shade associated with DNA methylation changes in Snapdragon plants (Antirrhinum majus)

Pierick Mouginot , Nelia Luviano Aparicio , Delphine Gourcilleau , Mathieu Latutrie , Sara Marin et al.
Genes, 2021, 12 (2), pp.227. ⟨10.3390/genes12020227⟩
Journal articles hal-03132536v1
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Satellite-like W Elements: repetitive, transcribed, and putative mobile genetic factors with potential roles for biology and evolution of Schistosoma mansoni

Maria Stitz , Cristian Chaparro , Zhigang Lu , V Janett Janett Olzog , Christina E Weinberg et al.
Genome Biology and Evolution, 2021, 13 (10), pp.evab204. ⟨10.1093/gbe/evab204⟩
Journal articles hal-03333536v1
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Environmentally Driven Color Variation in the Pearl Oyster Pinctada margaritifera var. cumingii (Linnaeus, 1758) Is Associated With Differential Methylation of CpGs in Pigment- and Biomineralization-Related Genes

Pierre-Louis Stenger , Chin-Long Ky , Céline M O Reisser , Céline Cosseau , Christoph Grunau et al.
Frontiers in Genetics, 2021, 12, pp.630290. ⟨10.3389/fgene.2021.630290⟩
Journal articles hal-03178846v1
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A simple ATAC-seq protocol for population epigenetics

Ronaldo de Carvalho Augusto , Olivier Rey , Céline Cosseau , Cristian Chaparro , Jeremie Vidal-Dupiol et al.
Wellcome Open Research, 2021, 5, pp.121. ⟨10.12688/wellcomeopenres.15552.2⟩
Journal articles hal-03145575v2
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The methylome of Biomphalaria glabrata and other mollusks: enduring modification of epigenetic landscape and phenotypic traits by a new DNA methylation inhibitor

Nelia Luviano , Marie Lopez , Fleur Gawehns , Cristian Chaparro , Paola B Arimondo et al.
Epigenetics & Chromatin, 2021, 14 (1), pp.48. ⟨10.1186/s13072-021-00422-7⟩
Journal articles pasteur-03427775v2
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Morphological and genomic characterisation of the Schistosoma hybrid infecting humans in Europe reveals admixture between Schistosoma haematobium and Schistosoma bovis

Julien Kincaid-Smith , Alan Tracey , Ronaldo de Carvalho Augusto , Ingo Bulla , Nancy Holroyd et al.
PLoS Neglected Tropical Diseases, 2021, 15 (12), pp.e0010062. ⟨10.1371/journal.pntd.0010062⟩
Journal articles hal-03508340v1
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DNA methylation during development and regeneration of the annelid Platynereis dumerilii

Anabelle Planques , Pierre Kerner , Laure L. Ferry , Christoph Grunau , Eve Gazave et al.
BMC Biology, 2021, 19, pp.148. ⟨10.1186/s12915-021-01074-5⟩
Journal articles hal-03083515v2
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Rhesus macaques self-curing from a schistosome infection can display complete immunity to challenge

Murilo Sena Amaral , Daisy Woellner Santos , Adriana S A Pereira , Ana Carolina Tahira , João V M Malvezzi et al.
Nature Communications, 2021, 12, ⟨10.1038/s41467-021-26497-0⟩
Journal articles hal-03414204v1
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RNAi suppression of DNA methylation affects the drought stress response and genome integrity in transgenic poplar

M.D. Sow , A.L. Le Gac , R. Fichot , S. Lanciano , A. Delaunay et al.
New Phytologist, 2021, 232 (1), pp.80-97. ⟨10.1111/nph.17555⟩
Journal articles hal-03292338v1
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Dosage compensation throughout the Schistosoma mansoni lifecycle: specific chromatin landscape of the Z chromosome

Marion Picard , Beatriz Vicoso , David Roquis , Ingo Bulla , Ronaldo de Carvalho Augusto et al.
Genome Biology and Evolution, 2019, 11 (7), pp.1909-1922. ⟨10.1093/gbe/evz133/5527757⟩
Journal articles hal-02177468v1
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Universality of the DNA methylation codes in Eucaryotes

Benoît Aliaga , Ingo Bulla , Gabriel Mouahid , David Duval , Christoph Grunau et al.
Scientific Reports, 2019, 9, pp.173. ⟨10.1038/s41598-018-37407-8⟩
Journal articles hal-01905101v1
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Effects of the environment on developmental plasticity and infection success of Schistosoma parasites – an epigenetic perspective

Ronaldo de Carvalho Augusto , David Duval , Christoph Grunau
Frontiers in Microbiology, 2019, 10, pp.1475. ⟨10.3389/fmicb.2019.01475⟩
Journal articles hal-02178309v1
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The Epigenetics Dilemma

Christoph Grunau , Jérémy Le Luyer , Martin Laporte , Dominique Joly
Genes, 2019, 11 (1), pp.23. ⟨10.3390/genes11010023⟩
Journal articles hal-02428660v1

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Peter Brown , Aik-Choon Tan , Mohamed El-Esawi , Thomas Liehr , Oliver Blanck et al.
Database - The journal of Biological Databases and Curation, 2019, 2019, ⟨10.1093/database/baz085⟩
Journal articles hal-03600728v1
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The Cytoplasm Affects the Epigenome in Drosophila melanogaster

Christoph Grunau , Susanne Voigt , Ralph Dobler , Damian Dowling , Klaus Reinhardt et al.
Epigenomes, 2018, 2 (3), pp.17. ⟨10.3390/epigenomes2030017⟩
Journal articles hal-01887456v1
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Parent-of-Origin Dependent Gene Expression in Male and Female Schistosome Parasites

Julien Kincaid-Smith , Marion A.-L. Picard , Celine Cosseau , Jerome Boissier , Dany Severac et al.
Genome Biology and Evolution, In press, 10 (3), pp.840-856. ⟨10.1093/gbe/evy037⟩
Journal articles hal-01729365v1
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Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni

David Roquis , Aaron Taudt , Kathrin P Geyer , Gilda Padalino , Karl F Hoffmann et al.
PLoS Pathogens, 2018, 14 (5), pp.e1007066. ⟨10.1371/journal.ppat.1007066⟩
Journal articles hal-01808531v1
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Evolution without standing genetic variation: change in transgenerational plastic response under persistent predation pressure

Arnaud Sentis , Raphaël Bertram , Nathalie Dardenne , Felipe Ramon-Portugal , Gilles Espinasse et al.
Heredity, 2018, 121 (3), pp.266-281. ⟨10.1038/s41437-018-0108-8⟩
Journal articles hal-01887396v1
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Notos -a galaxy tool to analyze CpN observed expected ratios for inferring DNA methylation types

Ingo Bulla , Benoît Aliaga , Virginia Lacal , Jan Bulla , Christoph Grunau et al.
BMC Bioinformatics, 2018, 19, pp.105. ⟨10.1186/s12859-018-2115-4⟩
Journal articles hal-01746203v1
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Transplantation of schistosome sporocysts between host snails: A video guide

Gabriel Mouahid , Anne Rognon , Ronaldo de Carvalho Augusto , Patrick Driguez , Kathy Geyer et al.
Wellcome Open Research, 2018, 3, pp.3. ⟨10.12688/wellcomeopenres.13488.1⟩
Journal articles hal-01729358v1
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(Epi)genetic inheritance in Schistosoma mansoni: a system approach

Céline Cosseau , Olaf Wolkenhauer , Gilda Padalino , Kathrin K. Geyer , Karl F. Hoffmann et al.
Trends in Parasitology, 2017, 1590, pp.285-294. ⟨10.1016/j.pt.2016.12.002⟩
Journal articles hal-01511049v1
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The compatibility between Biomphalaria glabrata snails and Schistosoma mansoni: an increasingly complex puzzle

Guillaume Mitta , Benjamin Gourbal , Christoph Grunau , M. Knight , J.M. Bridger et al.
Advances in Parasitology, 2017, 97, pp.111-145. ⟨10.1016/bs.apar.2016.08.006⟩
Journal articles hal-01511043v1
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Whole genome analysis of a schistosomiasis-transmitting freshwater snail

C. Adema , L. Hillier , C. Jones , E.S. Loker , M. Knight et al.
Nature Communications, 2017, 8, pp.15451. ⟨10.1038/ncomms15451⟩
Journal articles hal-01523953v1
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Double impact: natural molluscicide for schistosomiasis vector control also impedes development of Schistosoma mansoni cercariae into adult parasites

Ronaldo de Carvalho Augusto , Guillaume Tetreau , Philippe Chan , Marie-Laure Walet-Balieu , Clélia Christina Mello-Silva et al.
PLoS Neglected Tropical Diseases, 2017, 11 (7), pp.e0005789. ⟨10.1371/journal.pntd.0005789⟩
Journal articles hal-01598383v1
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The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni

Kathrin P Geyer , Umar P Niazi , David F Duval , Céline Cosseau , Chad T Tomlinson et al.
PLoS Neglected Tropical Diseases, 2017, 11 (5), pp.e0005246. ⟨10.1371/journal.pntd.0005246⟩
Journal articles hal-01523805v1
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Integrated multi-omic analyses in Biomphalaria-Schistosoma dialogue reveal the immunobiological significance of FREP- Sm PoMuc interaction

Anaïs Portet , Silvain Pinaud , Guillaume Tetreau , Richard Galinier , Céline Cosseau et al.
Developmental and Comparative Immunology, 2017, 75, pp.16 - 27. ⟨10.1016/j.dci.2017.02.025⟩
Journal articles hal-01598455v1
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A multistrain approach to studying the mechanisms underlying compatibility in the interaction between Biomphalaria glabrata and Schistosoma mansoni

Richard Galinier , Emmanuel Roger , Yves Moné , David Duval , Anaïs Portet et al.
PLoS Neglected Tropical Diseases, 2017, 11 (3), pp.e0005398. ⟨10.1371/journal.pntd.0005398.s005⟩
Journal articles hal-01511153v1
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Effects of a parental exposure to diuron on Pacific oyster spat methylome

Rodolfo Rondon , Christoph Grunau , Manon Fallet , Nicolas Charlemagne , Rossana Sussarellu et al.
Environmental Epigenetics, 2017, 3 (1), pp.dvx004. ⟨10.1093/eep/dvx004⟩
Journal articles hal-01511486v1
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Epigenetic origin of adaptive phenotypic variants in the human blood-fluke Schistosoma mansoni

Sara Fneich , André Théron , Céline Cosseau , Anne Rognon , Benoit Aliaga et al.
Epigenetics and Chromatin, 2016, 9, pp.227. ⟨10.1186/s13072-016-0076-2⟩
Journal articles hal-01364014v1
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Transcriptional changes in Crassostrea gigas oyster spat following a parental exposure to the herbicide diuron

Rodolfo Rondon , F. Akcha , P. Alonso , D. Menard , J. Rouxel et al.
Aquatic Toxicology, 2016, 175, pp.47-55. ⟨10.1016/j.aquatox.2016.03.007⟩
Journal articles hal-01311107v1
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Frequency and mitotic heritability of epimutations in Schistosoma mansoni

David Roquis , Anne Rognon , Cristian Chaparro , Jérôme Boissier , Nathalie Arancibia et al.
Molecular Ecology, 2016, EPIGENETIC STUDIES IN ECOLOGY AND EVOLUTION, 25 (8), pp.1741-1758. ⟨10.1111/mec.13555⟩
Journal articles hal-01311089v1
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Sex-biased transcriptome of Schistosoma mansoni: host-parasite interaction, genetic determinants and epigenetic regulators are associated with sexual differentiation

Marion R Picard , Jérôme Boissier , David R Roquis , Christoph Grunau , Jean-François Allienne et al.
PLoS Neglected Tropical Diseases, 2016, 10 (9), pp.e0004930. ⟨10.1371/journal.pntd.0004930.s010⟩
Journal articles hal-01387886v1
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The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection

David Roquis , Julie Mireille Lepesant , Marion A.L. Picard , M. Freitag , Hugues Parrinello et al.
PLoS Neglected Tropical Diseases, 2015, 9 (8), pp.e0003853. ⟨10.1371/journal.pntd.0003853⟩
Journal articles hal-01259820v1
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A family of variable immunoglobulin and lectin domain containing molecules in the snail Biomphalaria glabrata

Nolwenn M. Dheilly , David Duval , Gabriel Mouahid , Rémi Emans , Jean-François J. F. Allienne et al.
Developmental and Comparative Immunology, 2015, 48 (1), pp.234-243. ⟨10.1016/j.dci.2014.10.009⟩
Journal articles hal-01082870v1
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The roles of DMRT (Double sex/Male-abnormal-3 Related Transcription factor) genes in sex determination and differentiation mechanisms: ubiquity and diversity across the animal kingdom

Marion A.L. Picard , Céline Cosseau , Gabriel Mouahid , David Duval , Christoph Grunau et al.
Comptes Rendus Biologies, 2015, 338 (7), pp.451-462. ⟨10.1016/j.crvi.2015.04.010⟩
Journal articles hal-01163079v1
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Exposure to hycanthone alters chromatin structure around specific gene functions and specific repeats in Schistosoma mansoni.

David Roquis , Julie M. J. Lepesant , Emanuel Villafan , Jérôme Boissier , Cristina Vieira et al.
Frontiers in Genetics, 2014, 5, pp.207. ⟨10.3389/fgene.2014.00207⟩
Journal articles hal-01112701v1

No more non-model species: The promise of next generation sequencing for comparative immunology.

Nolwenn M. Dheilly , Coen Adema , David A Raftos , Benjamin Gourbal , Christoph Grunau et al.
Developmental and Comparative Immunology, 2014, 45 (1), pp.56-66. ⟨10.1016/j.dci.2014.01.022⟩
Journal articles hal-03779118v1

Metazoan parasite communities of catfishes (Teleostei: Siluridae) in Benin (West Africa).

N.D. Tossavi , A Gbankoto , A Adité , Moudachirou Ibikounlé , Christoph Grunau et al.
Parasitology Research, 2014, 113 (11), pp.3973-3983. ⟨10.1007/s00436-014-4063-x⟩
Journal articles hal-01112591v1
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Thermal Stress Triggers Broad Pocillopora damicornis Transcriptomic Remodeling, while Vibrio coralliilyticus Infection Induces a More Targeted Immuno-Suppression Response

Jeremie Vidal-Dupiol , Nolwenn M. Dheilly , Rodolfo Rondon , Christoph Grunau , Cé Line Cosseau et al.
PLoS ONE, 2014, 9 (9), pp.e107672. ⟨10.1371/journal.pone⟩
Journal articles hal-01112610v1
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Elucidating the molecular bases of epigenetic inheritance in non-model invertebrates: the case of the root-knot nematode Meloidogyne incognita

Laetitia Perfus-Barbeoch , Philippe Castagnone-Sereno , Michael Reichelt , Sara Fneich , David Roquis et al.
Frontiers in Physiology, 2014, 5, pp.211. ⟨10.3389/fphys.2014.00211⟩
Journal articles hal-01112344v1
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Female biased sex-ratio in Schistosoma mansoni after exposure to an allopatric intermediate host strain of Biomphalaria glabrata.

Julie M J Lepesant , Jérôme Boissier , Déborah Climent , Céline Cosseau , Christoph Grunau et al.
Experimental Parasitology, 2013, 135, pp.350-356. ⟨10.1016/j.exppara.2013.07.023⟩
Journal articles halsde-00856611v1

Genes Related to Ion-Transport and Energy Production Are Upregulated in Response to CO2-Driven pH Decrease in Corals: New Insights from Transcriptome Analysis

Jeremie Vidal-Dupiol , Didier Zoccola , Eric Tambutté , Christoph Grunau , Céline Cosseau et al.
PLoS ONE, 2013, 8 (3), pp.e58652. ⟨10.1371/journal.pone.0058652⟩
Journal articles hal-03779125v1
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Genes related to ion-transport and energy production are upregulated in response to CO2-Driven pH decrease in corals: new insights from transcriptome analysis

Jeremie Vidal-Dupiol , Didier Zoccola , Eric Tambutté , Christoph Grunau , Céline Cosseau et al.
PLoS ONE, 2013, 8 (3), pp.e58652
Journal articles halsde-00805879v1
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Private Selective Sweeps Identified from Next-Generation Pool-Sequencing Reveal Convergent Pathways under Selection in Two Inbred Schistosoma mansoni Strains.

Julie a J Clément , Eve Toulza , Mathieu Gautier , Hugues Parrinello , David Roquis et al.
PLoS Neglected Tropical Diseases, 2013, 7 (12), pp.e2591. ⟨10.1371/journal.pntd.0002591⟩
Journal articles hal-00938922v1
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Schistosoma mansoni mucin genes expression (SmPoMuc): an epigenetic control to shape the adaptation to new host

Cecile Perrin , Julie Mireille Lepesant , Emmanuel Roger , David Duval , Sara Fneich et al.
PLoS Pathogens, 2013, 9 (8), pp.e1003571. ⟨10.1371/journal.ppat.1003571⟩
Journal articles halsde-00856613v1
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5-methyl-cytosine and 5-hydroxy-methyl-cytosine in the genome of Biomphalaria glabrata, a snail intermediate host of Schistosoma mansoni.

Sara Fneich , Nolwenn M. Dheilly , Coen Adema , Anne Rognon , Michael Reichelt et al.
Parasites & Vectors, 2013, 6, pp.167. ⟨10.1186/1756-3305-6-167⟩
Journal articles halsde-00839033v1
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Applying ecological and evolutionary theory to cancer: a long and winding road

Frédéric Thomas , Daniel Fisher , Philippe Fort , Jean-Pierre Marie , Simon Daoust et al.
Evolutionary Applications, 2013, 6 (1), pp.1-10. ⟨10.1111/eva.12021⟩
Journal articles halsde-00790602v1
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Chromatin structure changes around satellite repeats on the Schistosoma mansoni female sex chromosome suggest a possible mechanism for sex chromosome emergence.

Julie Mj Lepesant , Celine Cosseau , Jerome Boissier , Michael Freitag , Julien Portela et al.
Genome Biology, 2012, 13 (2), pp.R14. ⟨10.1186/gb-2012-13-2-r14⟩
Journal articles halsde-00677346v1
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Combination of de-novo assembly of massive sequencing reads with classical repeat prediction improves identification of repetitive sequences in Schistosoma mansoni

Julie Mireille Lepesant , David Roquis , Rémi Emans , Céline Cosseau , Nathalie Arancibia et al.
Experimental Parasitology, 2012, 130 (4), pp.470-474. ⟨10.1016/j.exppara.2012.02.010⟩
Journal articles halsde-00674586v1

Vertebrate host protective immunity drives genetic diversity and antigenic polymorphism in Schistosoma mansoni.

S. Beltran , Benjamin Gourbal , Jérôme Boissier , David Duval , S. Kieffer-Jaquinod et al.
Journal of Evolutionary Biology, 2011, 24 (3), pp.554-72. ⟨10.1111/j.1420-9101.2010.02190.x⟩
Journal articles halsde-00580773v1
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Towards an understanding of the epigenetics of schistosomes: a comparative epigenomic study

J. M. J. Lepesant , Christoph Grunau , C. Cosseau
Memórias do Instituto Oswaldo Cruz, 2011, 106 (7), pp.823-830
Journal articles halsde-00643863v1
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Native chromatin immunoprecipitation.

Céline Cosseau , Christoph Grunau
Methods in Molecular Biology, 2011, 791, pp.195-212. ⟨10.1007/978-1-61779-316-5_15⟩
Journal articles halsde-00629480v1

Recent advances in Schistosoma genomics.

M. M. Mourão , Christoph Grunau , P. T. Loverde , M. K. Jones , G. Oliveira et al.
Parasite Immunology, 2011, 34 (2-3), pp.151-162. ⟨10.1111/j.1365-3024.2011.01349.x⟩
Journal articles halsde-00665474v1
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No evidence for lateral gene transfer between salmonids and schistosomes.

Christoph Grunau , Jérôme Boissier
Nature Genetics, 2010, 42 (11), pp.918-9. ⟨10.1038/ng1110-918⟩
Journal articles halsde-00608638v1

ZAP-70 intron1 DNA methylation status: Determination by pyrosequencing in B chronic lymphocytic leukemia

Sylvain Chantepie , Dominique Vaur , Christoph Grunau , Véronique Salaün , Mélanie Briand et al.
Leukemia Research, 2010, 34 (6), pp.800-808. ⟨10.1016/j.leukres.2009.10.018⟩
Journal articles hal-02358614v1

No evidence for large difference in genomic methylation between wild and hatchery steelhead (Oncorhynchus mykiss)

M.S. Blouin , V. Thuillier , B. Cooper , V. Amarasinghe , L. Cluzel et al.
Canadian Journal of Fisheries and Aquatic Sciences, 2010, 67 (2), pp.217-224. ⟨10.1139/F09-174⟩
Journal articles halsde-00495179v1
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Whole-genome in-silico subtractive hybridization (WISH) - using massive sequencing for the identification of unique and repetitive sex-specific sequences: the example of Schistosoma mansoni.

Julien Portela , Christoph Grunau , Celine Cosseau , Sophie Beltran , Christelle Dantec et al.
BMC Genomics, 2010, 11 (1), pp.387. ⟨10.1186/1471-2164-11-387⟩
Journal articles halsde-00495369v1
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Epigenetic and phenotypic variability in populaitons of Schistosoma mansoni - a possible kick-off for adaptative host/parasite evolution

Céline Cosseau , A. Azzi , A. Rognon , S. Gourbière , E. Roger et al.
Oikos, 2010, 119 (4), pp.669-678. ⟨10.1111/j.1600-0706.2009.18040.x⟩
Journal articles halsde-00495189v1

Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni.

Florence Dubois , Stéphanie Caby , Frédérik Oger , Céline Cosseau , Monique Capron et al.
Molecular and Biochemical Parasitology, 2009, 168 (1), pp.7-15. ⟨10.1016/j.molbiopara.2009.06.001⟩
Journal articles halsde-00459184v1
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Schistosoma mansoni: Developmental arrest of miracidia treated with histone deacetylase inhibitors

A. Azzi , C. Cosseau , Christoph Grunau
Experimental Parasitology, 2009, 121, pp.288-291. ⟨10.1016/j.exppara.2008.11.010⟩
Journal articles halsde-00371695v1
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Native chromatin immunoprecipitation (N-ChIP) and ChIP-Seq of Schistosoma mansoni: Critical experimental parameters.

Céline Cosseau , Abdelhalim Azzi , Kristina Smith , Michael Freitag , Guillaume Mitta et al.
Molecular and Biochemical Parasitology, 2009, 166 (1), pp.70-6. ⟨10.1016/j.molbiopara.2009.02.015⟩
Journal articles halsde-00459175v1

Molecular determinants of compatibility polymorphism in the Biomphalaria glabrata / Schistosoma mansoni model: New candidates identified by a global comparative proteomics approach

E. Roger , G. Mitta , Y. Moné , A. Bouchut , A. Rognon et al.
Molecular and Biochemical Parasitology, 2008, 157, pp.205-216. ⟨10.1016/j.molbiopara.2007.11.003⟩
Journal articles halsde-00286494v1

Expression analysis of highly polymorphic mucin proteins (Sm PoMuc) from the parasite Schistosoma mansoni

E. Roger , Benjamin Gourbal , Christoph Grunau , R.J. Pierce , Richard Galinier et al.
Molecular and Biochemical Parasitology, 2008, 157, pp.217-227. ⟨10.1016/j.molbiopara.2007.11.015⟩
Journal articles halsde-00286479v1

The compatibility polymorphism in invertebrate host/trematodes interactions: research of molecular determinants

A. Bouchut , E. Roger , Benjamin Gourbal , Christoph Grunau , C. Coustau et al.
Parasite, 2008, 15 (3), pp.304-309
Journal articles halsde-00344425v1

BAGE hypomethylation, a new epigenetic biomarker for colon cancer detection

Christoph Grunau , Me Brun , I. Rivals , Janick Selves , W. Hindermann et al.
Cancer Epidemiology, Biomarkers and Prevention, 2008, 17 (6), pp.1374-1379. ⟨10.1158/1055-9965.EPI-07-2656⟩
Journal articles hal-00289933v1
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The compatibility polymorphism in invertebrate host/trematode interactions : research of molecular determinants

A. Bouchut , Elise Roger , Benjamin Gourbal , Christoph Grunau , Christine Cousteau et al.
Parasite, 2008, 15, pp.304-309. ⟨10.1051/parasite/2008153304⟩
Journal articles hal-02668649v1
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Controlled chaos of polymorphic mucins in a metazoan parasite (Schistosoma mansoni) interacting with its invertebrate host (Biomphalaria glabrata).

Emmanuel Roger , Christoph Grunau , Raymond J. Pierce , Hirohisa Hirai , Benjamin Gourbal et al.
PLoS Neglected Tropical Diseases, 2008, 2 (11), pp.e330. ⟨10.1371/journal.pntd.0000330⟩
Journal articles halsde-00344615v1

Excretory-secretory proteome of larval Schistosoma mansoni and Echinostoma caproni, two parasites of Biomphalaria glabrata.

François Guillou , Emmanuel Roger , Yves Moné , Anne Rognon , Christoph Grunau et al.
Molecular and Biochemical Parasitology, 2007, 155 (1), pp.45-56. ⟨10.1016/j.molbiopara.2007.05.009⟩
Journal articles hal-00170690v1

Mapping of the juxtacentromeric heterochromatin-euchromatin frontier of human chromosome 21.

Christoph Grunau , J. Buard , Me Brun , Albertina de Sario
Genome Research, 2006, 16, pp.1198-1207. ⟨10.1101/gr.5440306⟩
Journal articles hal-00113088v1

Cyclin D1 Gene Activation in Human Myeloma Cells Is Independent of DNA Hypomethylation or Histone Hyperacetylation.

Krieger S , Christoph Grunau , Sabbah M , Brigitte Sola
Experimental Hematology, 2005, ⟨10.1016/j.exphem.2005.03.011⟩
Journal articles hal-01762030v1

Determinants and relative weight of genetic and epigenetic variation in the resistance of the oyster Crassostrea gigas to the Pacific Oyster Mortality Syndrome

Jeremie Vidal-Dupiol , Janan Gawra , Julien de Lorgeril , Yannick Gueguen , Fabrice Roux et al.
EPIMAR 2022, Oct 2022, Woods Hole, Massachussets, United States
Conference papers hal-03965076v1

Are cercarial emergence rhythms of the diurnal and nocturnal chronotypes of the parasite Schistosoma mansoni circadian ?

Chrystelle Lasica , Gabriel Mouahid , Chevalier F. , Winka Le Clec’h , Cristian Chaparro et al.
15th International Conference on Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases (MEEGID), Nov 2021, Online, United States
Conference papers hal-03428124v1

How to strain your oyster? A story of immune shaping and priming in the pacific oyster, Crassostrea gigas

C. Montagnani , Maxime Lafont , Bruno Petton , Julien de Lorgeril , Manon Fallet et al.
Aqua 2018 14th International Symposium on Aquaculture Nutrition, Aug 2018, Montpellier, France
Conference papers hal-03965651v1

A systems biology approach linking genetic, epigenetic, cytoplasmic and holobiont inheritance to understand rapid adaptation of parasitic flatworms (Schistosoma sp.)

Céline Cosseau , Eve Toulza , Richard Galinier , Benjamin Gourbal , Christoph Grunau et al.
66th Annual Meeting of the American Society of Tropical Medicine and Hygiene, Nov 2017, Baltimore, United States. pp.183
Conference papers hal-03132820v1

Recurrent bleaching inducing thermotolerance increases: a dive into the holobiont adaptability through (meta)genomic and epigenomic mechanisms

Jeremie Vidal-Dupiol , Eve R Toulza , Christoph Grunau , Cristian Chaparro , David R Roquis et al.
13th International Coral Reef Symposium, Jun 2016, Honolulu, United States. pp.357
Conference papers hal-03965822v1

Evolution adaptative : et si Lamarck avait raison ?

David Roquis , Céline Cosseau , Christoph Grunau
3e congrès pluridisciplinaire des Doctorants UPVD, Université de Perpignan Via Domitia, May 2014, Perpignan, France
Conference papers hal-01164367v1

L’héritabilité des mécanismes épigénétiques contrôlant le succès d’infestation du parasite Schistosoma mansoni

Sara Fneich , Céline Cosseau , André Théron , Anne Rognon , Guillaume Mitta et al.
9e Réunion du REID Réseau Ecologie des Interactions Durables, Feb 2014, Montpellier, France
Conference papers hal-01134509v1

The puzzle of cnidarians adaptation: an integrative approach

D. Aurelle , Jeremie Vidal-Dupiol , Anne Haguenauer , Christoph Grunau , Didier Forcioli et al.
14th Congress of the European Society for Evolutionary Biology ESEB, Aug 2013, Lisbonne, Portugal. pp.1330
Conference papers hal-03965877v1

Global coral transcriptomic responses to ocean acidification

Jeremie Vidal-Dupiol , Didier Zoccola , Éric Tambutté , Christoph Grunau , Céline Cosseau et al.
12th International Coral Reefs Symposium, Jul 2012, Cairns, Australia. pp.396
Conference papers hal-03965931v1

The immune response of Pocillopora damicornis confronted to Vibrio coralliilyticus

Jeremie Vidal-Dupiol , Ophélie Ladrière , Nolwenn M. Dheilly , Delphine Destoumieux-Garzón , Sylvie Tambutté et al.
12th International Coral Reefs Symposium ICRS, Jul 2012, Cairns, Australia. pp.396
Conference papers hal-03966000v1

A role for epigenetics in adaptative evolution

J. Lepesant , C. Cosseau , C. Perrin , G. Mitta , Christoph Grunau et al.
Young Researchers in Life Sciences, Jun 2010, Paris, France
Conference papers halsde-00495195v1

Des mucines polymorphes (SmPoMucs) au coeur de l'interaction entre B. glabrata et S. mansoni

E. Roger , Benjamin Gourbal , Christoph Grunau , R. Pierce , G. Mitta et al.
Réunion annuelle du Réseau Ecologie des Interactions Durables, Jan 2008, Tours, France
Conference papers halsde-00329976v1

Déterminants moléculaires de la compatibilité dans l'interaction Biomphalaria glabrata / Schistosoma mansoni : approche protéomique comparative et caractérisation des mucines polymorphes de S. mansoni (SmPoMuc)

Y. Moné , E. Roger , Christoph Grunau , Benjamin Gourbal , G. Mitta et al.
Immuninv 2008, Apr 2008, Montpellier, France
Conference papers halsde-00330460v1

Le polymorphisme de mucines (SmPoMucs) au coeur de l'interaction entre B. glabrata et S. mansoni : un "chaos contrôlé"

E. Roger , Christoph Grunau , H. Hirai , R. Pierce , Benjamin Gourbal et al.
Immuninv. 2008, Apr 2008, Montpellier, France
Conference papers halsde-00329916v1

Is the cercarial emission rhythm of the parasite Schistosoma mansoni circadian ?

Chrystelle Lasica , Gabriel Mouahid , Chevalier F.D. , Winka Le Clec’h , Cristian Chaparro et al.
18th Meeting of Ecology and Evolution of Infectious Diseases (EEID), Jun 2021, Montpellier, France
Conference poster hal-03428131v1

Is the cercarial emission rhythm of the parasite Schistosoma mansoni circadian?

Chrystelle Lasica , Gabriel Mouahid , Chevalier F.D. , Winka Le Clec’h , Cristian Chaparro et al.
86th Cold Spring Harbor Laboratory Symposium on Quantitative Biology: Biological Time Keeping, Jun 2021, Online, United States
Conference poster hal-03428135v1

Transgenerational response to early microbial exposure in the oyster Crassostrea gigas and positive impact on survival capacities to juvenile mortality syndrome

Manon Fallet , Bruno Petton , Julien de Lorgeril , Sébastien Comarmond , Cristian Chaparro et al.
5. Journée d'Animation Scientifique du réseau épiPhase, Jun 2019, Toulouse, France. 35 p., 2019, épiPHASE
Conference poster hal-02736036v1
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Clarifying the role of DNA methylation in tree phenotypic plasticity

Mamadou Dia Sow , Anne-Laure Le Gac , Clément Lafon Placette , Alain Delaunay , Isabelle Le Jan et al.
43. FEBS Congress, Biochemistry Forever, Jul 2018, Prague, Czech Republic. FEBS Open Bio, 8 (supplément S1), 2018, Supplément 43rd FEBS Congress, Biochemistry Forever, Prague, Czech Republic, July 7‐12, 2018
Conference poster hal-02736952v1
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Drought-induced acclimation of DNA-hypomethylated poplars

Anne-Laure Le Gac , Régis R. Fichot , Marie Mirouze , Vincent Segura , Alain Delaunay et al.
IUFRO Genomics and Forest Tree Genetics, May 2016, Arcachon, France. , 2016, IUFRO Genomics and Forest Tree Genetics. Abstract book
Conference poster hal-02742078v1
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Environmentally induced epigenetic plasticity in the human parasite Schistosoma mansoni

Céline Cosseau , Julie M J Lepesant , David Roquis , Nathalie Arancibia , Christoph Grunau et al.
Conférences Jacques Monod « Les maladies infectieuses comme moteur de l’évolution : les défis à venir », Sep 2014, Roscoff, France.
Conference poster hal-01134476v1
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Measuring histone modifications in the human parasite Schistosoma mansoni

Ronaldo de Carvalho Augusto , David Roquis , Marion Picard , Cristian Chaparro , Celine Cosseau et al.
David J. Timson. Schistosoma mansoni. Methods and Protocols, 2151, Springer, pp.93-107, 2020, Methods in Molecular Biology, 978-1-0716-0634-6. ⟨10.1007/978-1-0716-0635-3_9⟩
Book sections hal-03328481v1

Histone Methylome of the Human Parasite Schistosoma Mansoni

Ronaldo de Carvalho Augusto , Céline Cosseau , Christoph Grunau
The DNA, RNA, and Histone Methylomes. RNA Technologies, Springer, pp.607-624, 2019, 978-3-030-14791-4. ⟨10.1007/978-3-030-14792-1_24⟩
Book sections hal-03187605v1

Qu'est-ce que l'épigénétique ?

Francesca Merlin , Antonine Nicoglou , Christoph Grunau , Danchin Etienne
D Joly & C Grunau (dir.) Prospective épigénétique écologie & évolution, Une prospective de l'Institut écologie et environnement, N. 8 - Novembre 2018., 2018
Book sections hal-02926493v1

Polymorphic mucin-like proteins in Schistosoma mansoni, a variable antigen and a key component of the compatibility between the schistosome and its snail host

Benjamin Gourbal , André Théron , Christoph Grunau , David Duval , Guillaume Mitta et al.
Hsu, E.; Du Pasquier, L. Pathogen-host interactions: antigenic variation v. somatic adaptations, 57, Springer, pp.91-108, 2015, Results and problems in cell differentiation, 978-3319208183. ⟨10.1007/978-3-319-20819-0_4⟩
Book sections hal-03110515v1

Methylation mapping in humans

Christoph Grunau
Epigenetics: linking genotype and phenotype in development and evolution, University of California Press, pp.70-86, 2011, 978-0-520-94882-2
Book sections hal-00941929v1
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Targeted insertion of reporter transgene into a gene safe harbor in human blood fluke, Schistosoma mansoni

Wannaporn Ittiprasert Tanno , Max F Möscheid , Cristian Chaparro , Victoria H Mann , Thomas Quack et al.
2022
Preprints, Working Papers, ... hal-03771118v1
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Chromatin landscape dynamics in development of the plant parasitic nematode Meloidogyne incognita

Rahim Hassanaly-Goulamhoussen , Ronaldo de Carvalho Augusto , Nathalie Marteu-Garello , Arthur Péré , Bruno Favery et al.
2021
Preprints, Working Papers, ... hal-03227610v1
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The tropical coral Pocillopora acuta has a mosaic DNA methylome, an unusual chromatin structure and shows histone H3 clipping

David Roquis , Ariadna Picart Picolo , Kelly Brener Raffalli , Pascal Romans , Patrick Masanet et al.
2021
Preprints, Working Papers, ... hal-03239798v1
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Hypomethylated poplars show higher tolerance to water deficit and highlight a dual role for DNA methylation in shoot meristem: regulation of stress response and genome integrity

M.D. D Sow , A-L Le Gac , R. Fichot , S. Lanciano , A. Delaunay et al.
2021
Preprints, Working Papers, ... hal-03239719v1
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Sequencing, de novo assembly and annotation of the genome of the scleractinian coral, Pocillopora acuta

Jeremie Vidal-Dupiol , Cristian Chaparro , Marine Pratlong , Pierre Pontarotti , Christoph Grunau et al.
2021
Preprints, Working Papers, ... hal-03239739v1
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Chromatin structure changes in Daphnia populations upon exposure to environmental cues – or – The discovery of Wolterecks “Matrix”

Ronaldo de Carvalho Augusto , Aki Minoda , Oliver Rey , Céline Cosseau , Cristian Chaparro et al.
2020
Preprints, Working Papers, ... hal-02991174v1
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Whole genome sequencing and morphological analysis of the human-infecting schistosome emerging in Europe reveals a complex admixture between Schistosoma haematobium and Schistosoma bovis parasites

Julien Kincaid Smith , Alan Tracey , Ronaldo de Carvalho Augusto , Ingo Bulla , Nancy Holroyd et al.
2018
Preprints, Working Papers, ... hal-03134801v1