Access content directly

Christoph Grunau

Director IHPE
Open access
Current affiliations
  • 101475
Researcher identifiers


The goal of our group is to elucidate the multiple relations between environment, organisms and their fitness in the lab and in the field, in order to understand and control host-symbiont/parasite interactions. We see inheritance in a broad sense including genetic, epigenetic, cytoplasmic, and holobiont elements. My specialty is **evolutionary epigenetics**. Education *Sep 2011 – Sep 2011* **Université de Perpignan** HDR, Epigenetics Perpignan, France *Jan 1995 – Dec 1999* **IMB Jena** PhD, Epigenetics Jena, Thuringia, Germany *Sep 1994 – Dec 1995* **RIKEN** PreDoc, Microbiology Wako, Japan *Sep 1988 – Aug 1994* **Friedrich-Schiller-University Jena** Diploma, Biology Jena, Germany Research Experience *Jan 2021– present *Sep 2013 – present* **Director of IHPE (UMR5244)** **Professor (Full)** Université de Perpignan, Laboratory of Host-Pathogen-Environnement Interactions (IHPE) Perpignan, France *Sep 2007 – Aug 2013* **Professor (Assistant)** Université de Perpignan, Laboratory of Ecology and Evolution of Interactions 2EI Perpignan, France *Sep 2006 – Aug 2007* **PostDoc Position** Université de Perpignan, Perpignan, France *Jan 2000 – Mar 2005* **PostDoc Position** French National Centre for Scientific Research, Institut de Génétique Humaine Montpellier, Languedoc-Roussillon, France *Jan 1996 – Dec 1999* **PhD Student** Institute of Molecular Biotechnology, Jena, Jena, Thuringia, Germany *Oct 1994 – Dec 1995* **PreDoc** RIKEN, Intestinal Microbe Symbiosis Research Laboratory Wako, Saitama, Japan *Sep 1993 – Aug 1994* **Master** Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany


Image document

Targeted insertion and reporter transgene activity at a gene safe harbor of the human blood fluke, Schistosoma mansoni

Wannaporn Ittiprasert , Max F Moescheid , Cristian Chaparro , Victoria H Mann , Rutchanee Rodpai
Cell Reports Methods, 2023, 3 (7), pp.100535. ⟨10.1016/j.crmeth.2023.100535⟩
Journal articles hal-04181018v1
Image document

Epigenetic variations are more substantial than genetic variations in rapid adaptation of oyster to Pacific oyster mortality syndrome

Janan Gawra , Alejandro Valdivieso , Fabrice Roux , Martin Laporte , Julien de Lorgeril
Science Advances , 2023, 9 (36), pp.eadh899. ⟨10.1126/sciadv.adh8990⟩
Journal articles hal-04202595v1
Image document

Hit-and-Run Epigenetic Editing for Vectors of Snail-Borne Parasitic Diseases

Nelia Luviano , David Duval , Wannaporn Ittiprasert , Jean-François Allienne , Geneviève Tavernier
Frontiers in Cell and Developmental Biology, 2022, 10, pp.794650. ⟨10.3389/fcell.2022.794650⟩
Journal articles hal-03608918v1
Image document

Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection

Manon Fallet , C. Montagnani , Bruno Petton , Luc Dantan , Julien de Lorgeril
Microbiome, 2022, 10, pp.85. ⟨10.1186/s40168-022-01280-5⟩
Journal articles hal-03635473v2
Image document

Automated ChIPmentation procedure on limited biological material of the human blood fluke Schistosoma mansoni

Chrystelle Lasica , Ronaldo de Carvalho Augusto , Hélène Moné , Gabriel Mouahid , Cristian Chaparro
Wellcome Open Research, 2022, 7, pp.133. ⟨10.12688/wellcomeopenres.17779.1⟩
Journal articles hal-03255320v2
Image document

The tropical coral Pocillopora acuta displays an unusual chromatin structure and shows histone H3 clipping plasticity upon bleaching

David Roquis , Celine Cosseau , Kelly Brener Raffalli , Pascal Romans , Patrick Masanet
Wellcome Open Research, 2022, 6, pp.195. ⟨10.12688/wellcomeopenres.17058.2⟩
Journal articles hal-03315093v2
Image document

Getting out of crises: Environmental, social-ecological and evolutionary research is needed to avoid future risks of pandemics

Delphine Destoumieux-Garzón , Franziska Matthies-Wiesler , Nicolas Bierne , Aurélie Binot , Jérôme Boissier
Environment International, 2022, 158, 12 p. ⟨10.1016/j.envint.2021.106915⟩
Journal articles hal-03428100v1
Image document

Phenotypic response to light versus shade associated with DNA methylation changes in Snapdragon plants (Antirrhinum majus)

Pierick Mouginot , Nelia Luviano Aparicio , Delphine Gourcilleau , Mathieu Latutrie , Sara Marin
Genes, 2021, 12 (2), pp.227. ⟨10.3390/genes12020227⟩
Journal articles hal-03132536v1
Image document

Chromatin landscape dynamics in the early development of the plant parasitic nematode Meloidogyne incognita

Rahim Hassanaly-Goulamhoussen , Ronaldo de Carvalho Augusto , Nathalie Marteu-Garello , Arthur Péré , Bruno Favery
Frontiers in Cell and Developmental Biology, 2021, 9, pp.765690. ⟨10.1101/2021.05.11.443567⟩
Journal articles hal-03467409v2
Image document

Rhesus macaques self-curing from a schistosome infection can display complete immunity to challenge

Murilo Sena Amaral , Daisy Woellner Santos , Adriana S A Pereira , Ana Carolina Tahira , João V M Malvezzi
Nature Communications, 2021, 12, ⟨10.1038/s41467-021-26497-0⟩
Journal articles hal-03414204v1
Image document

The tropical coral Pocillopora acuta displays an unusual chromatin structure and shows histone H3 clipping plasticity upon bleaching

David Roquis , Céline Cosseau , Kelly Brener Raffalli , Pascal Romans , Patrick Masanet
Wellcome Open Research, 2021, 6, 195 (11p.). ⟨10.12688/wellcomeopenres.17058.1⟩
Journal articles hal-04203564v1
Image document

DNA methylation during development and regeneration of the annelid Platynereis dumerilii

Anabelle Planques , Pierre Kerner , Laure L. Ferry , Christoph Grunau , Eve Gazave
BMC Biology, 2021, 19, pp.148. ⟨10.1186/s12915-021-01074-5⟩
Journal articles hal-03083515v2
Image document

Morphological and genomic characterisation of the Schistosoma hybrid infecting humans in Europe reveals admixture between Schistosoma haematobium and Schistosoma bovis

Julien Kincaid-Smith , Alan Tracey , Ronaldo de Carvalho Augusto , Ingo Bulla , Nancy Holroyd
PLoS Neglected Tropical Diseases, 2021, 15 (12), pp.e0010062. ⟨10.1371/journal.pntd.0010062⟩
Journal articles hal-03508340v1
Image document

Satellite-like W Elements: repetitive, transcribed, and putative mobile genetic factors with potential roles for biology and evolution of Schistosoma mansoni

Maria Stitz , Cristian Chaparro , Zhigang Lu , V Janett Janett Olzog , Christina E Weinberg
Genome Biology and Evolution, 2021, 13 (10), pp.evab204. ⟨10.1093/gbe/evab204⟩
Journal articles hal-03333536v1
Image document

A simple ATAC-seq protocol for population epigenetics

Ronaldo de Carvalho Augusto , Olivier REY , Céline Cosseau , Cristian Chaparro , Jeremie Vidal-Dupiol
Wellcome Open Research, 2021, 5, pp.121. ⟨10.12688/wellcomeopenres.15552.2⟩
Journal articles hal-03145575v2
Image document

Environmentally Driven Color Variation in the Pearl Oyster Pinctada margaritifera var. cumingii (Linnaeus, 1758) Is Associated With Differential Methylation of CpGs in Pigment- and Biomineralization-Related Genes

Pierre-Louis Stenger , Chin-Long Ky , Céline M O Reisser , Céline Cosseau , Christoph Grunau
Frontiers in Genetics, 2021, 12, pp.630290. ⟨10.3389/fgene.2021.630290⟩
Journal articles hal-03178846v1
Image document

The methylome of Biomphalaria glabrata and other mollusks: enduring modification of epigenetic landscape and phenotypic traits by a new DNA methylation inhibitor

Nelia Luviano , Marie Lopez , Fleur Gawehns , Cristian Chaparro , Paola B Arimondo
Epigenetics & Chromatin, 2021, 14 (1), pp.48. ⟨10.1186/s13072-021-00422-7⟩
Journal articles pasteur-03427775v2
Image document

RNAi suppression of DNA methylation affects the drought stress response and genome integrity in transgenic poplar

Mamadou-Dia Sow , Anne‐laure Le Gac , Régis Fichot , Sophie Lanciano , Alain Delaunay
New Phytologist, 2021, 232 (1), pp.80-97. ⟨10.1111/nph.17555⟩
Journal articles hal-03292338v1
Image document

The insecticide permethrin induces transgenerational behavioral changes linked to transcriptomic and epigenetic alterations in zebrafish (Danio rerio)

Mélanie Blanc , Philipp Antczak , Xavier Cousin , Christoph Grunau , Nikolai Scherbak
Science of the Total Environment, 2021, 779, pp.146404. ⟨10.1016/j.scitotenv.2021.146404⟩
Journal articles hal-03175988v1
Image document

Universality of the DNA methylation codes in Eucaryotes

Benoît Aliaga , Ingo Bulla , Gabriel Mouahid , David Duval , Christoph Grunau
Scientific Reports, 2019, 9, pp.173. ⟨10.1038/s41598-018-37407-8⟩
Journal articles hal-01905101v1
Image document

Effects of the environment on developmental plasticity and infection success of Schistosoma parasites – an epigenetic perspective

Ronaldo de Carvalho Augusto , David Duval , Christoph Grunau
Frontiers in Microbiology, 2019, 10, pp.1475. ⟨10.3389/fmicb.2019.01475⟩
Journal articles hal-02178309v1
Image document

The Epigenetics Dilemma

Christoph Grunau , Jérémy Le Luyer , Martin Laporte , Dominique Joly
Genes, 2019, 11 (1), pp.23. ⟨10.3390/genes11010023⟩
Journal articles hal-02428660v1
Image document

Dosage compensation throughout the Schistosoma mansoni lifecycle: specific chromatin landscape of the Z chromosome

Marion Picard , Beatriz Vicoso , David Roquis , Ingo Bulla , Ronaldo de Carvalho Augusto
Genome Biology and Evolution, 2019, 11 (7), pp.1909-1922. ⟨10.1093/gbe/evz133/5527757⟩
Journal articles hal-02177468v1
Image document

Parent-of-Origin Dependent Gene Expression in Male and Female Schistosome Parasites

Julien Kincaid-Smith , Marion A.L. Picard , Eve Toulza , Celine Cosseau , Jerome Boissier
Genome Biology and Evolution, inPress, 10 (3), pp.840-856. ⟨10.1093/gbe/evy037⟩
Journal articles hal-01729365v1
Image document

Evolution without standing genetic variation: change in transgenerational plastic response under persistent predation pressure

Arnaud Sentis , Raphaël Bertram , Nathalie Dardenne , Felipe Ramon-Portugal , Gilles Espinasse
Heredity, 2018, 121 (3), pp.266-281. ⟨10.1038/s41437-018-0108-8⟩
Journal articles hal-01887396v1
Image document

Transplantation of schistosome sporocysts between host snails: A video guide

Gabriel Mouahid , Anne Rognon , Ronaldo de Carvalho Augusto , Patrick Driguez , Kathy Geyer
Wellcome Open Research, 2018, 3, pp.3. ⟨10.12688/wellcomeopenres.13488.1⟩
Journal articles hal-01729358v1
Image document

Notos -a galaxy tool to analyze CpN observed expected ratios for inferring DNA methylation types

Ingo Bulla , Benoît Aliaga , Virginia Lacal , Jan Bulla , Christoph Grunau
BMC Bioinformatics, 2018, 19, pp.105. ⟨10.1186/s12859-018-2115-4⟩
Journal articles hal-01746203v1
Image document

The Cytoplasm Affects the Epigenome in Drosophila melanogaster

Christoph Grunau , Susanne Voigt , Ralph Dobler , Damian Dowling , Klaus Reinhardt
Epigenomes, 2018, 2 (3), pp.17. ⟨10.3390/epigenomes2030017⟩
Journal articles hal-01887456v1
Image document

Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni

David Roquis , Aaron Taudt , Kathrin P Geyer , Gilda Padalino , Karl F Hoffmann
PLoS Pathogens, 2018, 14 (5), pp.e1007066. ⟨10.1371/journal.ppat.1007066⟩
Journal articles hal-01808531v1
Image document

(Epi)genetic inheritance in Schistosoma mansoni: a system approach

Celine Cosseau , Olaf Wolkenhauer , Gilda Padalino , Kathrin K. Geyer , Karl F. Hoffmann
Trends in Parasitology, 2017, 1590, pp.285-294. ⟨10.1016/⟩
Journal articles hal-01511049v1
Image document

The compatibility between Biomphalaria glabrata snails and Schistosoma mansoni: an increasingly complex puzzle

Guillaume Mitta , Benjamin Gourbal , Christoph Grunau , M. Knight , J.M. Bridger
Advances in Parasitology, 2017, 97, pp.111-145. ⟨10.1016/bs.apar.2016.08.006⟩
Journal articles hal-01511043v1
Image document

Whole genome analysis of a schistosomiasis-transmitting freshwater snail

C. Adema , L. Hillier , C. Jones , E.S. Loker , M. Knight
Nature Communications, 2017, 8, pp.15451. ⟨10.1038/ncomms15451⟩
Journal articles hal-01523953v1
Image document

Double impact: natural molluscicide for schistosomiasis vector control also impedes development of Schistosoma mansoni cercariae into adult parasites

Ronaldo de Carvalho Augusto , Guillaume Tetreau , Philippe Chan , Marie-Laure Walet-Balieu , Clélia Christina Mello-Silva
PLoS Neglected Tropical Diseases, 2017, 11 (7), pp.e0005789. ⟨10.1371/journal.pntd.0005789⟩
Journal articles hal-01598383v1
Image document

Effects of a parental exposure to diuron on Pacific oyster spat methylome

Rodolfo Rondon , Christoph Grunau , Manon Fallet , Nicolas Charlemagne , Rossana Sussarellu
Environmental Epigenetics, 2017, 3 (1), pp.dvx004. ⟨10.1093/eep/dvx004⟩
Journal articles hal-01511486v1
Image document

A multistrain approach to studying the mechanisms underlying compatibility in the interaction between Biomphalaria glabrata and Schistosoma mansoni

Richard Galinier , Emmanuel Roger , Yves Moné , David Duval , Anaïs Portet
PLoS Neglected Tropical Diseases, 2017, 11 (3), pp.e0005398. ⟨10.1371/journal.pntd.0005398.s005⟩
Journal articles hal-01511153v1
Image document

The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni

Kathrin P Geyer , Umar P Niazi , David F Duval , Celine Cosseau , Chad T Tomlinson
PLoS Neglected Tropical Diseases, 2017, 11 (5), pp.e0005246. ⟨10.1371/journal.pntd.0005246⟩
Journal articles hal-01523805v1
Image document

Integrated multi-omic analyses in Biomphalaria-Schistosoma dialogue reveal the immunobiological significance of FREP- Sm PoMuc interaction

Anaïs Portet , Silvain Pinaud , Guillaume Tetreau , Richard Galinier , Celine Cosseau
Developmental and Comparative Immunology, 2017, 75, pp.16 - 27. ⟨10.1016/j.dci.2017.02.025⟩
Journal articles hal-01598455v1
Image document

Epigenetic origin of adaptive phenotypic variants in the human blood-fluke Schistosoma mansoni

Sara Fneich , André Théron , Celine Cosseau , Anne Rognon , Benoit Aliaga
Epigenetics and Chromatin, 2016, 9, pp.227. ⟨10.1186/s13072-016-0076-2⟩
Journal articles hal-01364014v1
Image document

Transcriptional changes in Crassostrea gigas oyster spat following a parental exposure to the herbicide diuron

Rodolfo Rondon , F. Akcha , P. Alonso , D. Menard , J. Rouxel
Aquatic Toxicology, 2016, 175, pp.47-55. ⟨10.1016/j.aquatox.2016.03.007⟩
Journal articles hal-01311107v1
Image document

Frequency and mitotic heritability of epimutations in Schistosoma mansoni

David Roquis , Anne Rognon , Cristian Chaparro , Jérôme Boissier , Nathalie Arancibia
Molecular Ecology, 2016, EPIGENETIC STUDIES IN ECOLOGY AND EVOLUTION, 25 (8), pp.1741-1758. ⟨10.1111/mec.13555⟩
Journal articles hal-01311089v1
Image document

Sex-biased transcriptome of Schistosoma mansoni: host-parasite interaction, genetic determinants and epigenetic regulators are associated with sexual differentiation

Marion A.L. Picard , Jérôme Boissier , David R Roquis , Christoph Grunau , Jean-François Allienne
PLoS Neglected Tropical Diseases, 2016, 10 (9), pp.e0004930. ⟨10.1371/journal.pntd.0004930.s010⟩
Journal articles hal-01387886v1
Image document

The roles of DMRT (Double sex/Male-abnormal-3 Related Transcription factor) genes in sex determination and differentiation mechanisms: ubiquity and diversity across the animal kingdom

Marion A.L. Picard , Celine Cosseau , Gabriel Mouahid , David Duval , Christoph Grunau
Comptes Rendus. Biologies, 2015, 338 (7), pp.451-462. ⟨10.1016/j.crvi.2015.04.010⟩
Journal articles hal-01163079v1
Image document

A family of variable immunoglobulin and lectin domain containing molecules in the snail Biomphalaria glabrata

Nolwenn M. Dheilly , David Duval , Gabriel Mouahid , Rémi Emans , Jean-François Allienne
Developmental and Comparative Immunology, 2015, 48 (1), pp.234-243. ⟨10.1016/j.dci.2014.10.009⟩
Journal articles hal-01082870v1
Image document

The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection

David Roquis , Julie Mireille Lepesant , Marion A.L. Picard , Christoph Grunau , M. Freitag
PLoS Neglected Tropical Diseases, 2015, 9 (8), pp.e0003853. ⟨10.1371/journal.pntd.0003853⟩
Journal articles hal-01259820v1

Metazoan parasite communities of catfishes (Teleostei: Siluridae) in Benin (West Africa).

N.D. Tossavi , A Gbankoto , A Adité , Moudachirou Ibikounlé , Christoph Grunau
Parasitology Research, 2014, 113 (11), pp.3973-3983. ⟨10.1007/s00436-014-4063-x⟩
Journal articles hal-01112591v1
Image document

Elucidating the molecular bases of epigenetic inheritance in non-model invertebrates: the case of the root-knot nematode Meloidogyne incognita

Laetitia Perfus-Barbeoch , Philippe Castagnone-Sereno , Michael Reichelt , Sara Fneich , David Roquis
Frontiers in Physiology, 2014, 5, pp.211. ⟨10.3389/fphys.2014.00211⟩
Journal articles hal-01112344v1

No more non-model species: The promise of next generation sequencing for comparative immunology.

Nolwenn M. Dheilly , Coen Adema , David A Raftos , Benjamin Gourbal , Christoph Grunau
Developmental and Comparative Immunology, 2014, 45 (1), pp.56-66. ⟨10.1016/j.dci.2014.01.022⟩
Journal articles hal-03779118v1
Image document

Thermal Stress Triggers Broad Pocillopora damicornis Transcriptomic Remodeling, while Vibrio coralliilyticus Infection Induces a More Targeted Immuno-Suppression Response

Jeremie Vidal-Dupiol , Nolwenn M. Dheilly , Rodolfo Rondon , Christoph Grunau , Celine Cosseau
PLoS ONE, 2014, 9 (9), pp.e107672. ⟨10.1371/journal.pone⟩
Journal articles hal-01112610v1
Image document

Exposure to hycanthone alters chromatin structure around specific gene functions and specific repeats in Schistosoma mansoni.

David Roquis , Julie M. J. Lepesant , Emanuel Villafan , Jérôme Boissier , Cristina Vieira
Frontiers in Genetics, 2014, 5, pp.207. ⟨10.3389/fgene.2014.00207⟩
Journal articles hal-01112701v1

Genes Related to Ion-Transport and Energy Production Are Upregulated in Response to CO2-Driven pH Decrease in Corals: New Insights from Transcriptome Analysis

Jeremie Vidal-Dupiol , Didier Zoccola , Sylvie Tambutté , Eric Tambutté , Christoph Grunau
PLoS ONE, 2013, 8 (3), pp.e58652. ⟨10.1371/journal.pone.0058652⟩
Journal articles hal-03779125v1
Image document

Genes related to ion-transport and energy production are upregulated in response to CO2-Driven pH decrease in corals: new insights from transcriptome analysis

Jeremie Vidal-Dupiol , Didier Zoccola , Eric Tambutté , Christoph Grunau , Céline Cosseau
PLoS ONE, 2013, 8 (3), pp.e58652
Journal articles halsde-00805879v1
Image document

5-methyl-cytosine and 5-hydroxy-methyl-cytosine in the genome of Biomphalaria glabrata, a snail intermediate host of Schistosoma mansoni.

Sara Fneich , Nolwenn M. Dheilly , Coen Adema , Anne Rognon , Michael Reichelt
Parasites & Vectors, 2013, 6, pp.167. ⟨10.1186/1756-3305-6-167⟩
Journal articles halsde-00839033v1
Image document

Applying ecological and evolutionary theory to cancer: a long and winding road

Frédéric Thomas , Daniel Fisher , Philippe Fort , Jean-Pierre Marie , Simon Daoust
Evolutionary Applications, 2013, 6 (1), pp.1-10. ⟨10.1111/eva.12021⟩
Journal articles halsde-00790602v1
Image document

Female biased sex-ratio in Schistosoma mansoni after exposure to an allopatric intermediate host strain of Biomphalaria glabrata.

Julie M J Lepesant , Jérôme Boissier , Déborah Climent , Celine Cosseau , Christoph Grunau
Experimental Parasitology, 2013, 135, pp.350-356. ⟨10.1016/j.exppara.2013.07.023⟩
Journal articles halsde-00856611v1
Image document

Private Selective Sweeps Identified from Next-Generation Pool-Sequencing Reveal Convergent Pathways under Selection in Two Inbred Schistosoma mansoni Strains.

Julie a J Clément , Eve Toulza , Mathieu Gautier , Hugues Parrinello , David Roquis
PLoS Neglected Tropical Diseases, 2013, 7 (12), pp.e2591. ⟨10.1371/journal.pntd.0002591⟩
Journal articles hal-00938922v1
Image document

Schistosoma mansoni mucin genes expression (SmPoMuc): an epigenetic control to shape the adaptation to new host

Cecile Perrin , Julie Mireille Lepesant , Emmanuel Roger , David Duval , Sara Fneich
PLoS Pathogens, 2013, 9 (8), pp.e1003571. ⟨10.1371/journal.ppat.1003571⟩
Journal articles halsde-00856613v1
Image document

Chromatin structure changes around satellite repeats on the Schistosoma mansoni female sex chromosome suggest a possible mechanism for sex chromosome emergence.

Julie Mj Lepesant , Celine Cosseau , Jerome Boissier , Michael Freitag , Julien Portela
Genome Biology, 2012, 13 (2), pp.R14. ⟨10.1186/gb-2012-13-2-r14⟩
Journal articles halsde-00677346v1
Image document

Combination of de-novo assembly of massive sequencing reads with classical repeat prediction improves identification of repetitive sequences in Schistosoma mansoni

Julie Mireille Lepesant , David Roquis , Rémi Emans , Céline Cosseau , Nathalie Arancibia
Experimental Parasitology, 2012, 130 (4), pp.470-474. ⟨10.1016/j.exppara.2012.02.010⟩
Journal articles halsde-00674586v1

Vertebrate host protective immunity drives genetic diversity and antigenic polymorphism in Schistosoma mansoni.

S. Beltran , Benjamin Gourbal , Jérôme Boissier , David Duval , S. Kieffer-Jaquinod
Journal of Evolutionary Biology, 2011, 24 (3), pp.554-72. ⟨10.1111/j.1420-9101.2010.02190.x⟩
Journal articles halsde-00580773v1
Image document

Towards an understanding of the epigenetics of schistosomes: a comparative epigenomic study

J. M. J. Lepesant , Christoph Grunau , Celine Cosseau
Memórias do Instituto Oswaldo Cruz, 2011, 106 (7), pp.823-830
Journal articles halsde-00643863v1
Image document

Native chromatin immunoprecipitation.

Céline Cosseau , Christoph Grunau
Methods in Molecular Biology, 2011, 791, pp.195-212. ⟨10.1007/978-1-61779-316-5_15⟩
Journal articles halsde-00629480v1

Recent advances in Schistosoma genomics.

M. M. Mourão , Christoph Grunau , P. T. Loverde , M. K. Jones , G. Oliveira
Parasite Immunology, 2011, 34 (2-3), pp.151-162. ⟨10.1111/j.1365-3024.2011.01349.x⟩
Journal articles halsde-00665474v1

No evidence for large difference in genomic methylation between wild and hatchery steelhead (Oncorhynchus mykiss)

M.S. Blouin , V. Thuillier , B. Cooper , V. Amarasinghe , L. Cluzel
Canadian Journal of Fisheries and Aquatic Sciences, 2010, 67 (2), pp.217-224. ⟨10.1139/F09-174⟩
Journal articles halsde-00495179v1
Image document

Epigenetic and phenotypic variability in populaitons of Schistosoma mansoni - a possible kick-off for adaptative host/parasite evolution

Celine Cosseau , E. Roger , A. Azzi , Anne Rognon , Christoph Grunau
Oikos, 2010, 119 (4), pp.669-678. ⟨10.1111/j.1600-0706.2009.18040.x⟩
Journal articles halsde-00495189v1
Image document

ZAP-70 intron1 DNA methylation status: Determination by pyrosequencing in B chronic lymphocytic leukemia

Sylvain Chantepie , Dominique Vaur , Christoph Grunau , Véronique Salaün , Mélanie Briand
Leukemia Research, 2010, 34 (6), pp.800-808. ⟨10.1016/j.leukres.2009.10.018⟩
Journal articles hal-02358614v1
Image document

Whole-genome in-silico subtractive hybridization (WISH) - using massive sequencing for the identification of unique and repetitive sex-specific sequences: the example of Schistosoma mansoni.

Julien Portela , Christoph Grunau , Celine Cosseau , Sophie Beltran , Christelle Dantec
BMC Genomics, 2010, 11 (1), pp.387. ⟨10.1186/1471-2164-11-387⟩
Journal articles halsde-00495369v1
Image document

No evidence for lateral gene transfer between salmonids and schistosomes.

Christoph Grunau , Jérôme Boissier
Nature Genetics, 2010, 42 (11), pp.918-9. ⟨10.1038/ng1110-918⟩
Journal articles halsde-00608638v1
Image document

Schistosoma mansoni: Developmental arrest of miracidia treated with histone deacetylase inhibitors

A. Azzi , Celine Cosseau , Christoph Grunau
Experimental Parasitology, 2009, 121, pp.288-291. ⟨10.1016/j.exppara.2008.11.010⟩
Journal articles halsde-00371695v1
Image document

Native chromatin immunoprecipitation (N-ChIP) and ChIP-Seq of Schistosoma mansoni: Critical experimental parameters.

Celine Cosseau , Abdelhalim Azzi , Kristina Smith , Michael Freitag , Guillaume Mitta
Molecular and Biochemical Parasitology, 2009, 166 (1), pp.70-6. ⟨10.1016/j.molbiopara.2009.02.015⟩
Journal articles halsde-00459175v1

Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni.

Florence Dubois , Stéphanie Caby , Frédérik Oger , Celine Cosseau , Monique Capron
Molecular and Biochemical Parasitology, 2009, 168 (1), pp.7-15. ⟨10.1016/j.molbiopara.2009.06.001⟩
Journal articles halsde-00459184v1
Image document

Controlled chaos of polymorphic mucins in a metazoan parasite (Schistosoma mansoni) interacting with its invertebrate host (Biomphalaria glabrata).

Emmanuel Roger , Christoph Grunau , Raymond J. Pierce , Hirohisa Hirai , Benjamin Gourbal
PLoS Neglected Tropical Diseases, 2008, 2 (11), pp.e330. ⟨10.1371/journal.pntd.0000330⟩
Journal articles halsde-00344615v1

The compatibility polymorphism in invertebrate host/trematodes interactions: research of molecular determinants

A. Bouchut , E. Roger , Benjamin Gourbal , Christoph Grunau , C. Coustau
Parasite, 2008, 15 (3), pp.304-309
Journal articles halsde-00344425v1

BAGE hypomethylation, a new epigenetic biomarker for colon cancer detection

Christoph Grunau , Me Brun , I. Rivals , Janick Selves , W. Hindermann
Cancer Epidemiology, Biomarkers and Prevention, 2008, 17 (6), pp.1374-1379. ⟨10.1158/1055-9965.EPI-07-2656⟩
Journal articles hal-00289933v1

Molecular determinants of compatibility polymorphism in the Biomphalaria glabrata / Schistosoma mansoni model: New candidates identified by a global comparative proteomics approach

E. Roger , G. Mitta , Y. Moné , A. Bouchut , Anne Rognon
Molecular and Biochemical Parasitology, 2008, 157, pp.205-216. ⟨10.1016/j.molbiopara.2007.11.003⟩
Journal articles halsde-00286494v1

Expression analysis of highly polymorphic mucin proteins (Sm PoMuc) from the parasite Schistosoma mansoni

E. Roger , Benjamin Gourbal , Christoph Grunau , R.J. Pierce , Richard Galinier
Molecular and Biochemical Parasitology, 2008, 157, pp.217-227. ⟨10.1016/j.molbiopara.2007.11.015⟩
Journal articles halsde-00286479v1
Image document

The compatibility polymorphism in invertebrate host/trematode interactions : research of molecular determinants

A. Bouchut , Elise Roger , Benjamin Gourbal , Christoph Grunau , Christine Cousteau
Parasite, 2008, 15, pp.304-309. ⟨10.1051/parasite/2008153304⟩
Journal articles hal-02668649v1

Excretory-secretory proteome of larval Schistosoma mansoni and Echinostoma caproni, two parasites of Biomphalaria glabrata.

François Guillou , Emmanuel Roger , Yves Moné , Anne Rognon , Benjamin E F Gourbal
Molecular and Biochemical Parasitology, 2007, 155 (1), pp.45-56. ⟨10.1016/j.molbiopara.2007.05.009⟩
Journal articles hal-00170690v1

Mapping of the juxtacentromeric heterochromatin-euchromatin frontier of human chromosome 21.

Christoph Grunau , J. Buard , Me Brun , Albertina de Sario
Genome Research, 2006, 16, pp.1198-1207. ⟨10.1101/gr.5440306⟩
Journal articles hal-00113088v1

Cyclin D1 Gene Activation in Human Myeloma Cells Is Independent of DNA Hypomethylation or Histone Hyperacetylation.

Krieger S , Christoph Grunau , Sabbah M , Brigitte Sola
Experimental Hematology, 2005, ⟨10.1016/j.exphem.2005.03.011⟩
Journal articles hal-01762030v1

Determinants and relative weight of genetic and epigenetic variation in the resistance of the oyster Crassostrea gigas to the Pacific Oyster Mortality Syndrome

Jeremie Vidal-Dupiol , Janan Gawra , Julien de Lorgeril , Yannick Gueguen , Fabrice Roux
EPIMAR 2022, Oct 2022, Woods Hole (MA), United States
Conference papers hal-03965076v1
Image document

New insights into the role of DNA methylation in Biomphalaria glabrata infection susceptibility

Nelia Luviano , Marie Lopez , Fleur Gawehns , Cristian Chaparro , Paola B Arimondo
XVI Symposium on Schistosomiasis, FIOCRUZ, Nov 2022, Ouro Preto, Brazil
Conference papers hal-03963335v1

Temperature-induced masculinisation of Nile tilapia: effects seen in the adult gonad

H. d'Cotta , R. Sissao , L. Rebordinos , Christoph Grunau , K. Belkhir
14ht International Congress in the Biology of Fish, American Fisheries Society, Jun 2022, Montpellier, France
Conference papers hal-03976732v1

Are cercarial emergence rhythms of the diurnal and nocturnal chronotypes of the parasite Schistosoma mansoni circadian ?

Chrystelle Lasica , Gabriel Mouahid , Chevalier F. , Winka Le Clec’h , Cristian Chaparro
15th International Conference on Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases (MEEGID), Nov 2021, Online, United States
Conference papers hal-03428124v1

How to strain your oyster? A story of immune shaping and priming in the pacific oyster, Crassostrea gigas

C. Montagnani , Maxime Lafont , Bruno Petton , Julien de Lorgeril , Manon Fallet
Aqua 2018 14th International Symposium on Aquaculture Nutrition, Aug 2018, Montpellier, France
Conference papers hal-03965651v1

A systems biology approach linking genetic, epigenetic, cytoplasmic and holobiont inheritance to understand rapid adaptation of parasitic flatworms (Schistosoma sp.)

Céline Cosseau , Eve Toulza , Richard Galinier , Benjamin Gourbal , Christoph Grunau
66th Annual Meeting of the American Society of Tropical Medicine and Hygiene, Nov 2017, Baltimore, United States. pp.183
Conference papers hal-03132820v1

Recurrent bleaching inducing thermotolerance increases: a dive into the holobiont adaptability through (meta)genomic and epigenomic mechanisms

Jeremie Vidal-Dupiol , Eve R Toulza , Christoph Grunau , Cristian Chaparro , David R Roquis
13th International Coral Reef Symposium, Jun 2016, Honolulu, United States. pp.357
Conference papers hal-03965822v1

L’héritabilité des mécanismes épigénétiques contrôlant le succès d’infestation du parasite Schistosoma mansoni

Sara Fneich , Celine Cosseau , André Théron , Anne Rognon , Guillaume Mitta
9e Réunion du REID Réseau Ecologie des Interactions Durables, Feb 2014, Montpellier, France
Conference papers hal-01134509v1

Evolution adaptative : et si Lamarck avait raison ?

David Roquis , Céline Cosseau , Christoph Grunau
3e congrès pluridisciplinaire des Doctorants UPVD, Université de Perpignan Via Domitia, May 2014, Perpignan, France
Conference papers hal-01164367v1

Stratégies et méthodes de RNA-seq appliquées aux questions écologiques sur organismes non modèles

Jeremie Vidal-Dupiol , Christoph Grunau , Céline Cosseau , Michael Freitag , Guillaume Mitta
Journée de Conférences: Exploration de la Biodiversité par NGS, de nouveaux horizons ?, May 2013, Marseille, France
Conference papers hal-03968980v1

Possible epigenetic origin of thermal stress adaptation of the tropical coral Pocillopora damicornis

David Roquis , Jeremie Vidal-Dupiol , Céline Cosseau , G. Mitta , Christoph Grunau
Colloque CNRS Epigénétique en Ecologie et Evolution, Réseau Thématique Pluridisciplinaire Epigénétique en Ecologie et Evolution CNRS, Dec 2013, Gif-sur-Yvette, France
Conference papers hal-03968975v1

The puzzle of cnidarians adaptation: an integrative approach

D. Aurelle , Jeremie Vidal-Dupiol , Anne Haguenauer , Christoph Grunau , Didier Forcioli
14th Congress of the European Society for Evolutionary Biology ESEB, Aug 2013, Lisbonne, Portugal. pp.1330
Conference papers hal-03965877v1

Global coral transcriptomic responses to ocean acidification

Jeremie Vidal-Dupiol , Didier Zoccola , Éric Tambutté , Christoph Grunau , Céline Cosseau
12th International Coral Reefs Symposium, Jul 2012, Cairns, Australia. pp.396
Conference papers hal-03965931v1

The immune response of Pocillopora damicornis confronted to Vibrio coralliilyticus

Jeremie Vidal-Dupiol , Ophélie Ladrière , Nolwenn M. Dheilly , Delphine Destoumieux-Garzón , Sylvie Tambutté
Immunologie des Invertébrés IMMUNINV 2012, 2012, Perpignan, France. pp.22
Conference papers hal-03969008v1

The immune response of Pocillopora damicornis confronted to Vibrio coralliilyticus

Jeremie Vidal-Dupiol , Ophélie Ladrière , Nolwenn M. Dheilly , Delphine Destoumieux-Garzón , Sylvie Tambutté
12th International Coral Reefs Symposium ICRS, Jul 2012, Cairns, Australia. pp.396
Conference papers hal-03966000v1

The immune response of Pocillopora damicornis confronted to Vibrio coralliilyticus: a RNA-seq approach

Jeremie Vidal-Dupiol , Nolwenn Dheilly , Christoph Grunau , Céline Cosseau , Michael Freitag
3e Journée du réseau "Interactions Micro-organismes Hôtes" IMH, Réseau Interactions Micro-organismes Hôtes, Nov 2011, Montpellier, France
Conference papers hal-03969030v1

A role for epigenetics in adaptative evolution

J. Lepesant , C. Cosseau , C. Perrin , G. Mitta , Christoph Grunau
Young Researchers in Life Sciences, Jun 2010, Paris, France
Conference papers halsde-00495195v1

Déterminants moléculaires de la compatibilité dans l'interaction Biomphalaria glabrata / Schistosoma mansoni : approche protéomique comparative et caractérisation des mucines polymorphes de S. mansoni (SmPoMuc)

Y. Moné , E. Roger , Christoph Grunau , Benjamin Gourbal , G. Mitta
Immuninv 2008, Apr 2008, Montpellier, France
Conference papers halsde-00330460v1

Le polymorphisme de mucines (SmPoMucs) au coeur de l'interaction entre B. glabrata et S. mansoni : un "chaos contrôlé"

E. Roger , Christoph Grunau , H. Hirai , R. Pierce , Benjamin Gourbal
Immuninv. 2008, Apr 2008, Montpellier, France
Conference papers halsde-00329916v1

Des mucines polymorphes (SmPoMucs) au coeur de l'interaction entre B. glabrata et S. mansoni

E. Roger , Benjamin Gourbal , Christoph Grunau , R. Pierce , G. Mitta
Réunion annuelle du Réseau Ecologie des Interactions Durables, Jan 2008, Tours, France
Conference papers halsde-00329976v1

Epi(genetic) determinants of resistance in the Pacific oyster Crassostrea gigas: A case study in natural population

Janan Gawra , Jean-Baptiste Lamy , Mathilde Saccas , Julien de Lorgeril , Yannick Gueguen
18th EEID Ecology and Evolution of Infectious Diseases Meeting, Jun 2021, Online, France.
Conference poster hal-03971618v1

Is the cercarial emission rhythm of the parasite Schistosoma mansoni circadian?

Chrystelle Lasica , Gabriel Mouahid , Chevalier F.D. , Winka Le Clec’h , Cristian Chaparro
86th Cold Spring Harbor Laboratory Symposium on Quantitative Biology: Biological Time Keeping, Jun 2021, Online, United States
Conference poster hal-03428135v1

Is the cercarial emission rhythm of the parasite Schistosoma mansoni circadian ?

Chrystelle Lasica , Gabriel Mouahid , Chevalier F.D. , Winka Le Clec’h , Cristian Chaparro
18th Meeting of Ecology and Evolution of Infectious Diseases (EEID), Jun 2021, Montpellier, France
Conference poster hal-03428131v1

Integrative approach of the resistance mechanisms to the mass mortality syndrome affecting the juvenile of the oyster Crassostrea gigas (POMS)

Janan Gawra , J.B. Lamy , Mathilde Saccas , Julien de Lorgeril , Yannick Gueguen
First Epigenetic In Marine Biology Congress EPIMAR, Oct 2020, Montpellier ( Virtual Conference ), France.
Conference poster hal-03969100v1

Transgenerational response to early microbial exposure in the oyster Crassostrea gigas and positive impact on survival capacities to juvenile mortality syndrome

Manon Fallet , Bruno Petton , Julien de Lorgeril , Sébastien Comarmond , Cristian Chaparro
5. Journée d'Animation Scientifique du réseau épiPhase, Jun 2019, Toulouse, France. 35 p., 2019, épiPHASE
Conference poster hal-02736036v1
Image document

Clarifying the role of DNA methylation in tree phenotypic plasticity

Mamadou Dia Sow , Anne-Laure Le Gac , Clément Lafon Placette , Alain Delaunay , Isabelle Le Jan
43. FEBS Congress, Biochemistry Forever, Jul 2018, Prague, Czech Republic. FEBS Open Bio, 8 (supplément S1), 2018, Supplément 43rd FEBS Congress, Biochemistry Forever, Prague, Czech Republic, July 7‐12, 2018
Conference poster hal-02736952v1

Epigenetic and genetic mechanisms of trained adaptation to global warming in corals

Jeremie Vidal-Dupiol , Eve R Toulza , Christoph Grunau , Olivier Rey , David Roquis
EVOLUTION 2018 - 2nd Joint Congress on Evolutionary Biology, Aug 2018, Montellier, France.
Conference poster hal-03969153v1
Image document

Drought-induced acclimation of DNA-hypomethylated poplars

Anne-Laure Le Gac , Régis R. Fichot , Marie Mirouze , Vincent Segura , Alain Delaunay
IUFRO Genomics and Forest Tree Genetics, May 2016, Arcachon, France. , 2016, IUFRO Genomics and Forest Tree Genetics. Abstract book
Conference poster hal-02742078v1

Roles of epigenetic mechanisms in Dauermodifikations and adaptative evolution

David Roquis , Ariadna Picart-Picolo , Jeremie Vidal-Dupiol , Celine Cosseau , Christoph Grunau
Ecole thématique CNRS "Eco-Evo-Epigen", May 2015, St Pierre d'Oléron, France
Conference poster hal-04007854v1
Image document

Environmentally induced epigenetic plasticity in the human parasite Schistosoma mansoni

Céline Cosseau , Julie M J Lepesant , David Roquis , Nathalie Arancibia , Christoph Grunau
Conférences Jacques Monod « Les maladies infectieuses comme moteur de l’évolution : les défis à venir », Sep 2014, Roscoff, France.
Conference poster hal-01134476v1

Mécanismes épigénétiques des interactions hôte-agent pathogène

Christoph Grunau , Isabelle Fudal , Nadia Ponts
Editions Quae. Epigénétique. Mécanismes moléculaires, biologie du développement et réponses à l'environnement, Editions Quae, pp.133-144, 2024, 978-2-7592-3769-2
Book sections hal-04613807v1

Claude Combes et l'épigénétique

Christoph Grunau
Michel Delseny; Joseph Jourdane. Claude Combes Biologiste et Enseignant, Presses Universitaires de Perpignan, pp.103-105, 2022, 978-2-35412-470-0
Book sections hal-04025781v1
Image document

Measuring histone modifications in the human parasite Schistosoma mansoni

Ronaldo de Carvalho Augusto , David Roquis , Marion Picard , Cristian Chaparro , Celine Cosseau
David J. Timson. Schistosoma mansoni. Methods and Protocols, 2151, Springer, pp.93-107, 2020, Methods in Molecular Biology, 978-1-0716-0634-6. ⟨10.1007/978-1-0716-0635-3_9⟩
Book sections hal-03328481v1

Histone Methylome of the Human Parasite Schistosoma Mansoni

Ronaldo de Carvalho Augusto , Céline Cosseau , Christoph Grunau
The DNA, RNA, and Histone Methylomes. RNA Technologies, Springer, pp.607-624, 2019, 978-3-030-14791-4. ⟨10.1007/978-3-030-14792-1_24⟩
Book sections hal-03187605v1

Qu'est-ce que l'épigénétique ?

Francesca Merlin , Antonine Nicoglou , Christoph Grunau , Danchin Etienne
D Joly & C Grunau (dir.) Prospective épigénétique écologie & évolution, Une prospective de l'Institut écologie et environnement, N. 8 - Novembre 2018., 2018
Book sections hal-02926493v1

Polymorphic mucin-like proteins in Schistosoma mansoni, a variable antigen and a key component of the compatibility between the schistosome and its snail host

Benjamin Gourbal , André Théron , Christoph Grunau , David Duval , Guillaume Mitta
Hsu, E.; Du Pasquier, L. Pathogen-host interactions: antigenic variation v. somatic adaptations, 57, Springer, pp.91-108, 2015, Results and problems in cell differentiation, 978-3319208183. ⟨10.1007/978-3-319-20819-0_4⟩
Book sections hal-03110515v1

Methylation mapping in humans

Christoph Grunau
Epigenetics: linking genotype and phenotype in development and evolution, University of California Press, pp.70-86, 2011, 978-0-520-94882-2
Book sections hal-00941929v1
Image document

Epigenetic then genetic variations underpin rapid adaptation of oyster populations (Crassostrea gigas ) to Pacific Oyster Mortality Syndrome (POMS)

Janan Gawra , Alejandro Valdivieso , Fabrice Roux , Martin Laporte , Julien de Lorgeril
Preprints, Working Papers, ... hal-04651019v1
Image document

Enhanced efficiency of RNA-guided CASI2a versus CAS9 transgene knock-in and activity at a Schistosoma mansoni genome safe harbor

Max F Moescheid , Prapakorn Wisitphongpun , Victoria H Mann , Thomas Quack , Christoph Grunau
Preprints, Working Papers, ... hal-04650982v1
Image document

Heterochromatin protein 1 (HP1) ofSchistosoma mansoni: non-canonical chromatin landscape and fitness effects

Natália S da Trindade , Marilia Bergamini Valentini , Anne Rognon , Tiago Manuel Fernandes Mendes , Silmara Marques Allegretti
Preprints, Working Papers, ... hal-04515279v1
Image document

Chromatin structure around long non-coding RNA (lncRNA) genes in Schistosoma mansoni gonads

Ronaldo de Carvalho Augusto , Thomas Quack , Christoph G. Grevelding , Christoph Grunau
Preprints, Working Papers, ... hal-04472912v1
Image document

An epigenetic molluscicide

Nelia Luviano , Ludovic Halby , Corinne Jallet , Paola B Arimondo , Celine Cosseau
Preprints, Working Papers, ... hal-04157076v1
Image document

Targeted insertion of reporter transgene into a gene safe harbor in human blood fluke, Schistosoma mansoni

Wannaporn Ittiprasert Tanno , Max F Möscheid , Cristian Chaparro , Victoria H Mann , Thomas Quack
Preprints, Working Papers, ... hal-03771118v1
Image document

Sequencing, de novo assembly and annotation of the genome of the scleractinian coral, Pocillopora acuta

Jeremie Vidal-Dupiol , Cristian Chaparro , Marine Pratlong , Pierre Pontarotti , Christoph Grunau
Preprints, Working Papers, ... hal-03239739v1
Image document

Hypomethylated poplars show higher tolerance to water deficit and highlight a dual role for DNA methylation in shoot meristem: regulation of stress response and genome integrity

M.D. D Sow , A-L Le Gac , R. Fichot , S. Lanciano , A. Delaunay
Preprints, Working Papers, ... hal-03239719v1
Image document

The tropical coral Pocillopora acuta has a mosaic DNA methylome, an unusual chromatin structure and shows histone H3 clipping

David Roquis , Ariadna Picart Picolo , Kelly Brener Raffalli , Pascal Romans , Patrick Masanet
Preprints, Working Papers, ... hal-03239798v1
Image document

Chromatin structure changes in Daphnia populations upon exposure to environmental cues – or – The discovery of Wolterecks “Matrix”

Ronaldo de Carvalho Augusto , Aki Minoda , Oliver Rey , Céline Cosseau , Cristian Chaparro
Preprints, Working Papers, ... hal-02991174v1
Image document

Whole genome sequencing and morphological analysis of the human-infecting schistosome emerging in Europe reveals a complex admixture between Schistosoma haematobium and Schistosoma bovis parasites

Julien Kincaid Smith , Alan Tracey , Ronaldo de Carvalho Augusto , Ingo Bulla , Nancy Holroyd
Preprints, Working Papers, ... hal-03134801v1