CHRISTOPHE ARNOULT

85%

Open access

Documents

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1043222

Researcher identifiers

christophe-arnoult
0000-0002-3753-5901
IdRef : 097411833

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Publications

	Sperm fertility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA Charline Vilpreux , Guillaume Martinez , Magali Court , Florence Appaix , Jean-Luc Duteyrat eLife, 2024, ⟨10.7554/eLife.94514.1⟩ Journal articles hal-04780939v1
	Phenotypic continuum and poor intracytoplasmic sperm injection intracytoplasmic sperm injection prognosis in patients harboring HENMT1 variants Zeina Wehbe , Anne‐laure Barbotin , Angèle Boursier , Caroline Cazin , Jean‐pascal Hograindleur Andrology, 2024, Online ahead of print. ⟨10.1111/andr.13730⟩ Journal articles hal-04781935v1
	CNN-based approach for 3D artifact correction of intensity diffraction tomography images William Pierré , Matéo Briard , Guillaume Godefroy , Sylvia Desissaire , Magali Dhellemmes Optics Express, 2024, 32 (20), pp.34825. ⟨10.1364/OE.523289⟩ Journal articles hal-04757422v1
	Phenotypic continuum and poor intracytoplasmic sperm injection intracytoplasmic sperm injection prognosis in patients harboring HENMT1 variants. Zeina Wehbe , Anne-Laure Barbotin , Angèle Boursier , Caroline Cazin , Jean‐pascal Hograindleur Andrology, In press, Online ahead of print. ⟨10.1111/andr.13730⟩ Journal articles hal-04700579v1
	Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse Jana Muroňová , Zine-Eddine Kherraf , Elsa Giordani , Simon Eckert , Caroline Cazin eLife, 2024, ⟨10.7554/eLife.86845.2⟩ Journal articles hal-04236524v1
	A splice donor variant of GAS8 induces structural disorganization of the axoneme in sperm flagella and leads to nonsyndromic male infertility Zine-Eddine Kherraf , Anne-Laure Barbotin , Guillaume Martinez , Aurélien Mazet , Caroline Cazin Clinical Genetics, 2024, 105 (2), pp.220-225. ⟨10.1111/cge.14450⟩ Journal articles hal-04780903v1
	Expanding the sperm phenotype caused by mutations in SPATA20: A novel splicing mutation in an infertile patient with partial globozoospermia Guillaume Martinez , Catherine Metzler-Guillemain , Caroline Cazin , Zine-Eddine Kherraf , Odile Paulmyer-Lacroix Clinical Genetics, 2023, 103 (5), pp.612-614. ⟨10.1111/cge.14284⟩ Journal articles hal-04254105v1
	A splice donor variant of GAS8 induces structural disorganization of the axoneme in sperm flagella and leads to nonsyndromic male infertility Zine‐eddine Kherraf , Anne‐laure Barbotin , Guillaume Martinez , Aurélien Mazet , Caroline Cazin Clinical Genetics, 2023, 105 (2), pp.220-225. ⟨10.1111/cge.14450⟩ Journal articles hal-04601943v1
	Genetic causes of macrozoospermia and proposal for an optimized genetic diagnosis strategy based on sperm parameters Alicia Coudert , Caroline Cazin , Amir Amiri-Yekta , Selima Fourati Ben Mustapha , Raoudha Zouari International Journal of Genetics and Genomics, 2023, 50 (7), pp.536-540. ⟨10.1016/j.jgg.2023.04.007⟩ Journal articles hal-04256999v2
	New Mutations in DNHD1 Cause Multiple Morphological Abnormalities of the Sperm Flagella Guillaume Martinez , Anne-Laure Barbotin , Caroline Cazin , Zeina Wehbe , Angèle Boursier International Journal of Molecular Sciences, 2023, 24 (3), pp.2559. ⟨10.3390/ijms24032559⟩ Journal articles hal-04011973v1
	Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function Denis Dacheux , Guillaume Martinez , Christine Broster Reix , Julie Beurois , Patrick Lorès eLife, 2023, ⟨10.7554/eLife.87698.2⟩ Journal articles hal-04241708v1
	3D time-lapse imaging of a mouse embryo using intensity diffraction tomography embedded inside a deep learning framework William Pierré , Lionel Hervé , Chiara Paviolo , Ondrej Mandula , Vincent Remondiere Applied optics, 2022, 61 (12), pp.3337. ⟨10.1364/AO.453910⟩ Journal articles hal-03874593v1
	Combined Use of Whole Exome Sequencing and CRISPR/Cas9 to Study the Etiology of Non-Obstructive Azoospermia: Demonstration of the Dispensable Role of the Testis-Specific Genes C1orf185 and CCT6B Caroline Cazin , Yasmine Neirijnck , Corinne Loeuillet , Lydia Wehrli , Françoise Kühne Cells, 2022, 11 (1), pp.118. ⟨10.3390/cells11010118⟩ Journal articles hal-03717887v1
	A recurrent ZP1 variant is responsible for oocyte maturation defect with degenerated oocytes in infertile females Corinne Loeuillet , Magali Dhellemmes , Caroline Cazin , Zine‐eddine Kherraf , Selima Fourati Ben Mustapha Clinical Genetics, 2022, 102 (1), pp.22-29. ⟨10.1111/cge.14144⟩ Journal articles hal-03720194v1
	Dual role of histone variant H3.3B in spermatogenesis: positive regulation of piRNA transcription and implication in X-chromosome inactivation Emeline Fontaine , Christophe Papin , Guillaume Martinez , Stéphanie Le Gras , Roland Abi Nahed Nucleic Acids Research, 2022, 50 (13), pp.7350-7366. ⟨10.1093/nar/gkac541⟩ Journal articles hal-03852700v1
	When idiopathic male infertility is rooted in maternal malnutrition during the perinatal period in mice Yuki Muranishi , Laurent Parry , Mélanie Vachette-Dit-Martin , Fabrice Saez , Cécile Coudy-Gandilhon Biology of Reproduction, 2022, 106 (3), pp.463-476. ⟨10.1093/biolre/ioab222⟩ Journal articles hal-03474813v1
	Whole-exome sequencing improves the diagnosis and care of men with non-obstructive azoospermia Zine-Eddine Kherraf , Caroline Cazin , Amine Bouker , Selima Fourati Ben Mustapha , Sylviane Hennebicq American Journal of Human Genetics, 2022, 109 (3), pp.508-517. ⟨10.1016/j.ajhg.2022.01.011⟩ Journal articles hal-03718022v1
	Oligogenic heterozygous inheritance of sperm abnormalities in mouse Guillaume Martinez , Charles Coutton , Corinne Loeuillet , Caroline Cazin , Jana Muroňová eLife, 2022, 11, pp.e75373. ⟨10.7554/eLife.75373⟩ Journal articles hal-03818177v1
	From azoospermia to macrozoospermia, a phenotypic continuum due to mutations in the ZMYND15 gene Zine-Eddine Kherraf , Caroline Cazin , Florence Lestrade , Jana Muronova , Charles Coutton Asian Journal of Andrology, 2022, 24 (3), pp.243-247. ⟨10.4103/aja202194⟩ Journal articles hal-03720221v1
	Treatment of Mouse Sperm with a Non-Catalytic Mutant of PLA2G10 Reveals That PLA2G10 Improves In Vitro Fertilization through Both Its Enzymatic Activity and as Ligand of PLA2R1 Roland Abi Nahed , Magali Dhellemmes , Christine Payré , Emilie Le Blévec , Jean-Philippe Perrier International Journal of Molecular Sciences, 2022, 23 (14), pp.8033. ⟨10.3390/ijms23148033⟩ Journal articles hal-03818170v1
	New insights in Cercopithecinae spermatozoa Guillaume Martinez , Cécile Garcia , Céline Francois-Brazier , Sylvie Laidebeure , Antoine Leclerc Zygote, 2021, 29 (5), pp.401-409. ⟨10.1017/S0967199421000186⟩ Journal articles hal-03405430v1
	Defect in the nuclear pore membrane glycoprotein 210-like gene is associated with extreme uncondensed sperm nuclear chromatin and male infertility: a case report Karim Arafah , Fabrice Lopez , Caroline Cazin , Zine‐eddine Kherraf , Virginie Tassistro Human Reproduction, 2021, 36 (3), pp.693-701. ⟨10.1093/humrep/deaa329⟩ Journal articles hal-02985525v1
	The sodium/proton exchanger SLC9C1 ( sNHE ) is essential for human sperm motility and fertility Emma Cavarocchi , Marjorie Whitfield , Ahmed Chargui , Laurence Stouvenel , Patrick Lorès Clinical Genetics, 2021, 99 (5), pp.684-693. ⟨10.1111/cge.13927⟩ Journal articles hal-03369825v1
	Bi-allelic truncating variants in CFAP206 cause male infertility in human and mouse Qunshan Shen , Guillaume Martinez , Hongbin Liu , Julie Beurois , Huan Wu Human Genetics, 2021, 140 (9), pp.1367-1377. ⟨10.1007/s00439-021-02313-z⟩ Journal articles hal-03365264v1
	Identification and Characterization of the Most Common Genetic Variant Responsible for Acephalic Spermatozoa Syndrome in Men Originating from North Africa Caroline Cazin , Yasmine Boumerdassi , Guillaume Martinez , Selima Fourati Ben Mustapha , Marjorie Whitfield International Journal of Molecular Sciences, 2021, 22 (4), pp.2187. ⟨10.3390/ijms22042187⟩ Journal articles hal-03365058v1
	A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl Syndrome Patrick Lorès , Zine-Eddine Kherraf , Amir Amiri-Yekta , Marjorie Whitfield , Abbas Daneshipour Human Genetics, 2021, 140 (7), pp.1031-1043. ⟨10.1007/s00439-021-02270-7⟩ Journal articles hal-03369854v1
	Genetic analyses of a large cohort of infertile patients with globozoospermia, DPY19L2 still the main actor, GGN confirmed as a guest player Tristan Celse , Caroline Cazin , Flore Mietton , Guillaume Martinez , Delphine Martinez Human Genetics, 2021, Molecular Genetics of Male Infertility, 140 (1), pp.43-57. ⟨10.1007/s00439-020-02229-0⟩ Journal articles hal-03025179v1
	Deslorelin acetate implant induces transient sterility and behavior changes in male olive baboon ( Papio anubis ): A case study Guillaume Martinez , Romain Lacoste , Marie Dumasy , Slaveia Garbit , Sophie Brouillet Journal of Medical Primatology, 2020, 49 (6), pp.344-348. ⟨10.1111/jmp.12479⟩ Journal articles hal-03005083v1
	Pantoprazole, a proton‐pump inhibitor, impairs human sperm motility and capacitation in vitro Jessica Escoffier , Bastien Arnaud , Mayis Kaba , Jean Pascal Hograindleur , Emilie Le Blévec Andrology, 2020, 8 (6), pp.1795-1804. ⟨10.1111/andr.12855⟩ Journal articles hal-03005086v1
	Genetics of teratozoospermia: Back to the head Julie Beurois , Caroline Cazin , Zine-Eddine Kherraf , Guillaume Martinez , Tristan Celse Best Practice and Research: Clinical Endocrinology and Metabolism, 2020, 34 (6), pp.101473. ⟨10.1016/j.beem.2020.101473⟩ Journal articles hal-03004973v1
	Identification, Characterization and Synthesis of Walterospermin, a Sperm Motility Activator from the Egyptian Black Snake Walterinnesia aegyptia Venom Tarek Mohamed Abd El-Aziz , Lucie Jaquillard , Sandrine Bourgoin-Voillard , Guillaume Martinez , Mathilde Triquigneaux International Journal of Molecular Sciences, 2020, 21 (20), pp.7786. ⟨10.3390/ijms21207786⟩ Journal articles hal-02994665v1
	Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility Chunyu Liu , Haruhiko Miyata , Yang Gao , Yanwei Sha , Shuyan Tang American Journal of Human Genetics, 2020, 107 (2), pp.330-341. ⟨10.1016/j.ajhg.2020.06.004⟩ Journal articles hal-03004971v1
	Paternal epigenetics: Mammalian sperm provide much more than DNA at fertilization Emilie Le Blévec , Jana Muroňová , Pierre Ray , Christophe Arnoult Molecular and Cellular Endocrinology, 2020, 518, pp.110964. ⟨10.1016/j.mce.2020.110964⟩ Journal articles hal-03005088v1
	Biallelic variants in MAATS1 encoding CFAP91, a calmodulin-associated and spoke-associated complex protein, cause severe astheno-teratozoospermia and male infertility Guillaume Martinez , Julie Beurois , Denis Dacheux , Caroline Cazin , Marie Bidart Journal of Medical Genetics, 2020, 57 (10), pp.708-716. ⟨10.1136/jmedgenet-2019-106775⟩ Journal articles hal-03004959v1
	Identification, Characterization and Synthesis of Walterospermin, a Sperm Motility Activator from the Egyptian Black Snake Walterinnesia aegyptia Venom Tarek Mohamed Abd El-Aziz , Lucie Jaquillard , Sandrine Bourgoin-Voillard , Guillaume Martinez , Mathilde Triquigneaux International Journal of Molecular Sciences, 2020, 21 (20), pp.7786. ⟨10.3390/ijms21207786⟩ Journal articles hal-02996274v1
	Diversity of RNA-Binding Proteins Modulating Post-Transcriptional Regulation of Protein Expression in the Maturing Mammalian Oocyte Marie Christou-Kent , Magali Dhellemmes , Emeline Lambert , Pierre Ray , Christophe Arnoult Cells, 2020, 9 (3), pp.662. ⟨10.3390/cells9030662⟩ Journal articles hal-03005093v1
	The genetic architecture of morphological abnormalities of the sperm tail Aminata Touré , Guillaume Martinez , Zine-Eddine Kherraf , Caroline Cazin , Julie Beurois Human Genetics, 2020, ⟨10.1007/s00439-020-02113-x⟩ Journal articles hal-03004953v1
	Effects of timing of artificial insemination and treatment of semen with a Slo3 potassium channel blocker on fertility of dairy heifers subjected to the 5-day CIDR-Synch protocol C.C. Figueiredo , D.Z. Bisinotto , R.C. Chebel , W.W. Thatcher , Christophe Arnoult Journal of Dairy Science, 2020, 103 (8), pp.7462-7471. ⟨10.3168/jds.2019-18103⟩ Journal articles hal-03005090v1
	Complexity and diversity of sperm physiology Christophe Arnoult Molecular and Cellular Endocrinology, 2020, 518, pp.111002. ⟨10.1016/j.mce.2020.111002⟩ Journal articles hal-03005029v1
	Identification, Characterization and Synthesis of Walterospermin, a Sperm Motility Activator from the Egyptian Black Snake Walterinnesia aegyptia Venom Tarek Mohamed Abd El-Aziz , Lucie Jaquillard , Sandrine Bourgoin-Voillard , Guillaume Martinez , Mathilde Triquigneaux International Journal of Molecular Sciences, 2020, 21 (20), pp.7786. ⟨10.3390/ijms21207786⟩ Journal articles hal-04550844v1
	Whole exome sequencing of men with multiple morphological abnormalities of the sperm flagella reveals novel homozygous QRICH2 mutations Zine‐eddine Kherraf , Caroline Cazin , Charles Coutton , Amir Amiri‐yekta , Guillaume Martinez Clinical Genetics, 2019, 96 (5), pp.394-401. ⟨10.1111/cge.13604⟩ Journal articles hal-02347512v1
	Bi-allelic Mutations in ARMC2 Lead to Severe Astheno-Teratozoospermia Due to Sperm Flagellum Malformations in Humans and Mice C. Coutton , G. Martinez , Z.-E. Kherraf , A. Amiri-Yekta , M. Boguenet American Journal of Human Genetics, 2019, 104 (2), pp.331-340. ⟨10.1016/j.ajhg.2018.12.013⟩ Journal articles hal-02003335v1
	Enzymatic activity of mouse group X-sPLA2 improves in vitro production of preimplantation bovine embryos Guillaume Martinez , Jean-Pascal Hograindleur , Louise Jeammet , Emilie Le Blévec , Charles Coutton Theriogenology, 2019, 131, pp.113-122. ⟨10.1016/j.theriogenology.2019.03.030⟩ Journal articles hal-02324031v1
	Genetic causes of male infertility: snapshot on morphological abnormalities of the sperm flagellum Jean-Fabrice Nsota Mbango , Charles Coutton , Christophe Arnoult , Pierre Ray , Aminata Touré Basic and clinical andrology, 2019, 29 (1), ⟨10.1186/s12610-019-0083-9⟩ Journal articles hal-02350815v1
	Mutations in TTC29, Encoding an Evolutionarily Conserved Axonemal Protein, Result in Asthenozoospermia and Male Infertility Patrick Lorès , Denis Dacheux , Zine-Eddine Kherraf , Jean-Fabrice Nsota Mbango , Charles Coutton American Journal of Human Genetics, 2019, ⟨10.1016/j.ajhg.2019.10.007⟩ Journal articles hal-02370384v1
	CFAP70 mutations lead to male infertility due to severe astheno-teratozoospermia. Julie Beurois , Guillaume Martinez , Caroline Cazin , Zine-Eddine Kherraf , Amir Amiri-Yekta Human Reproduction, 2019, 96 (5), pp.394-401. ⟨10.1093/humrep/dez166⟩ Journal articles hal-02322935v1
	Whole-exome sequencing identifies mutations in FSIP2 as a recurrent cause of multiple morphological abnormalities of the sperm flagella Guillaume Martinez , Zine-Eddine Kherraf , Raoudha Zouari , Selima Fourati Ben Mustapha , Antoine Saut Human Reproduction, 2018, 33 (10), pp.1973 - 1984. ⟨10.1093/humrep/dey264⟩ Journal articles hal-01877993v1
	Échec de maturation ovocytaire Marie Christou-Kent , Pierre F. Ray , Christophe Arnoult Médecine/Sciences, 2018, 34 (12), pp.1042-1045. ⟨10.1051/medsci/2018287⟩ Journal articles hal-02970098v1
	A Homozygous Ancestral SVA-Insertion-Mediated Deletion in WDR66 Induces Multiple Morphological Abnormalities of the Sperm Flagellum and Male Infertility. Zine-Eddine Kherraf , Amir Amiri-Yekta , Denis Dacheux , Thomas Karaouzène , Charles Coutton American Journal of Human Genetics, 2018, 103 (3), pp.400-412. ⟨10.1016/j.ajhg.2018.07.014⟩ Journal articles hal-01863586v1
	PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and mice Marie Christou‐kent , Zine‐eddine Kherraf , Amir Amiri‐yekta , Emilie Le Blévec , Thomas Karaouzène EMBO Molecular Medicine, 2018, 10 (5), pp.e8515. ⟨10.15252/emmm.201708515⟩ Journal articles hal-01877992v1
	Absence of CFAP69 Causes Male Infertility due to Multiple Morphological Abnormalities of the Flagella in Human and Mouse Frederick Dong , Amir Amiri-Yekta , Guillaume Martinez , Antoine Saut , Julie Tek American Journal of Human Genetics, 2018, 102 (4), pp.636 - 648. ⟨10.1016/j.ajhg.2018.03.007⟩ Journal articles hal-01877985v1
	Actiflagelin, a new sperm activator isolated from Walterinnesia aegyptia venom using phenotypic screening Tarek Mohamed Abd El-Aziz , Sawsan Al Khoury , Lucie Jaquillard , Mathilde Triquigneaux , Guillaume Martinez Journal of Venomous Animals and Toxins including Tropical Diseases, 2018, 24 (1), pp.2. ⟨10.1186/s40409-018-0140-4⟩ Journal articles hal-01833333v1
	Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in $Trypanosoma$ and human. Charles Coutton , Alexandra S. Vargas , Amir Amiri-Yekta , Zine-Eddine Kherraf , Selima Fourati Ben Mustapha Nature Communications, 2018, 9, pp.686. ⟨10.1038/s41467-017-02792-7⟩ Journal articles hal-01724640v1
	Homozygous missense mutation L673P in adenylate kinase 7 (AK7) leads to primary male infertility and multiple morphological anomalies of the flagella but not to primary ciliary dyskinesia Patrick Lorès , Charles Coutton , Elma El Khouri , Laurence Stouvenel , Maelle Givelet Human Molecular Genetics, 2018, 27 (7), pp.1196-1211. ⟨10.1093/hmg/ddy034⟩ Journal articles hal-02346745v1
	Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility Tiziana Giordano , Sudarshan Gadadhar , Satish Bodakuntla , Jonas Straub , Sophie Leboucher Journal of Cell Science, 2018, 132 (3), pp.jcs226951. ⟨10.1242/jcs.226951⟩ Journal articles hal-02375075v1
	SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia inhomozygotes Zine-Eddine Kherraf , Marie Christou-Kent , Thomas Karaouzene , Amir Amiri-Yekta , Guillaume Martinez EMBO Molecular Medicine, 2017, 9 (8), pp.1132-1149. ⟨10.15252/emmm.201607461⟩ Journal articles hal-01741725v1
	Spermaurin, an La1-like peptide from the venom of the scorpion Scorpio maurus palmatus , improves sperm motility and fertilization in different mammalian species Guillaume Martinez , Jean-Pascal Hograindleur , Sébastien Voisin , Roland Abi Nahed , Tarek M. Abd El Aziz Molecular Human Reproduction, 2017, 23 (2), pp.116-131. ⟨10.1093/molehr/gaw075⟩ Journal articles hal-01618630v1
	Crucial Role for Immune Complexes but Not FcRn in Immunization against Anti–TNF-α Antibodies after a Single Injection in Mice Christophe Arnoult , Guillaume Brachet , Diana Cadena Castaneda , Nicolas Azzopardi , Christophe Passot Journal of Immunology, 2017, 199 (2), pp.418-424. ⟨10.4049/jimmunol.1601246⟩ Journal articles hal-02019721v1
	MAP6 interacts with Tctex1 and Cav 2.2/N-type calcium channels to regulate calcium signalling in neurons Jacques Brocard , Fabrice Dufour , Sylvie Gory-Fauré , Christophe Arnoult , Christophe Bosc European Journal of Neuroscience, 2017, Equipe IIb, 46 (11), pp.2754--2767. ⟨10.1111/ejn.13766⟩ Journal articles hal-01832939v1
	Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP Jessica Escoffier , Hoi Chang Lee , Sandra Yassine , Raoudha Zouari , Guillaume Martinez Human Molecular Genetics, 2016, 25 (5), pp.878 - 891. ⟨10.1093/hmg/ddv617⟩ Journal articles hal-01877966v1
	Dpy19l2-deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development Sandra Yassine , Jessica Escoffier , Guillaume Martinez , Charles Coutton , Thomas Karaouzene Molecular Human Reproduction, 2015, 21, pp.169-185. ⟨10.1093/molehr/gau099⟩ Journal articles cea-01745397v1
	Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella. Mariem Ben Khelifa , Charles Coutton , Raoudha Zouari , Thomas Karaouzène , John Rendu American Journal of Human Genetics, 2014, 94 (1), pp.95-104. ⟨10.1016/j.ajhg.2013.11.017⟩ Journal articles pasteur-01061012v1
	Fine Characterisation of a Recombination Hotspot at the DPY19L2 Locus and Resolution of the Paradoxical Excess of Duplications over Deletions in the General Population. Charles Coutton , Farid Abada , Thomas Karaouzene , Damien Sanlaville , Véronique Satre PLoS Genetics, 2013, 9 (3), pp.e1003363. ⟨10.1371/journal.pgen.1003363⟩ Journal articles hal-00809646v1
	Comparative testicular transcriptome of wild type and globozoospermic Dpy19l2 knock out mice Thomas Karaouzène , Michèle El Atifi , Jean-Paul Issartel , Marianne Grepillat , Charles Coutton Basic and Clinical Andrology, 2013, 23 (1), pp.7 Journal articles inserm-00880088v1
	Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy. Abir Tadmouri , Shigeki Kiyonaka , Maud Barbado , Matthieu Rousset , Katell Fablet EMBO Journal, 2012, 31 (18), pp.3730-44. ⟨10.1038/emboj.2012.226⟩ Journal articles inserm-00757285v1
	Identification of a new recurrent Aurora kinase C mutation in both European and African men with macrozoospermia. Mariem Ben Khelifa , Charles Coutton , Michael G B Blum , Farid Abada , Radu Harbuz Human Reproduction, 2012, 27 (11), pp.3337-46. ⟨10.1093/humrep/des296⟩ Journal articles hal-00775889v1
	A new AURKC mutation causing macrozoospermia: implications for human spermatogenesis and clinical diagnosis. Mariem Ben Khelifa , Raoudha Zouari , Radu Harbuz , Lazhar Halouani , Christophe Arnoult Molecular Human Reproduction, 2011, 17 (12), pp.762-8. ⟨10.1093/molehr/gar050⟩ Journal articles inserm-00639414v1
	Group X secreted phospholipase A₂ specifically decreases sperm motility in mice. Jessica Escoffier , Virginie J Pierre , Ikram Jemel , Léa Munch , Zied Boudhraa Journal of Cellular Physiology, 2011, 226 (10), pp.2601-9. ⟨10.1002/jcp.22606⟩ Journal articles hal-00731431v1
	In vitro and in vivo intracellular delivery of quantum dots by maurocalcine Narendra Ram , Isabelle Texier-Nogues , Karine Pernet-Gallay , Cathy Poillot , Fabienne Pirollet International Journal of Biomedical Nanoscience and Nanotechnology, 2011, 2 (1), pp.12-32. ⟨10.1504/IJBNN.2011.038464⟩ Journal articles inserm-00608347v1
	Could modifications of signalling pathways activated after ICSI induce a potential risk of epigenetic defects ? Brigitte Ciapa , Christophe Arnoult International Journal of Developmental Biology, 2011, 55 (2), pp.143-52. ⟨10.1387/ijdb.103122bc⟩ Journal articles hal-00722631v1
	A recurrent deletion of DPY19L2 causes infertility in man by blocking sperm head elongation and acrosome formation. Radu Harbuz , Raoudha Zouari , Virginie Pierre , Mariem Ben Khelifa , Mahmoud Kharouf American Journal of Human Genetics, 2011, 88 (3), pp.351-61. ⟨10.1016/j.ajhg.2011.02.007⟩ Journal articles inserm-00588067v1
	The development of high quality seals for silicon patch-clamp chips. Thomas Sordel , Frédérique Kermarrec , Yann Sinquin , Isabelle Fonteille , Michel Labeau Biomaterials, 2010, 31 (28), pp.7398-410. ⟨10.1016/j.biomaterials.2010.06.015⟩ Journal articles inserm-00498745v1
	Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice. Jessica Escoffier , Ikram Jemel , Akemi Tanemoto , Yoshitaka Taketomi , Christine Payre Journal of Clinical Investigation, 2010, 120 (5), pp.1415-28. ⟨10.1172/JCI40494⟩ Journal articles hal-00497561v1
	Iodination increases the activity of verapamil derivatives in reversing PGP multidrug resistance. Régis Barattin , Bastien Gerby , Kevin Bourges , Gaëlle Hardy , Jose Olivares Anticancer Research, 2010, 30 (7), pp.2553-9 Journal articles hal-02353716v1
	Snake venoms as a source of compounds modulating sperm physiology: Secreted phospholipases A2 from Oxyuranus scutellatus scutellatus impact sperm motility, acrosome reaction and in vitro fertilization in mice. Jessica Escoffier , Morgane Couvet , Harold de Pomyers , Pierre F. Ray , Michel Seve Biochimie, 2010, 92 (7), pp.826-36. ⟨10.1016/j.biochi.2010.03.003⟩ Journal articles hal-00497569v1
	Expression, localization and functions in acrosome reaction and sperm motility of Ca(V)3.1 and Ca(V)3.2 channels in sperm cells: an evaluation from Ca(V)3.1 and Ca(V)3.2 deficient mice. Jessica Escoffier , Sylvie Boisseau , Catherine Serres , Chien-Chang Chen , Daesoo Kim Journal of Cellular Physiology, 2007, 212 (3), pp.753-63. ⟨10.1002/jcp.21075⟩ Journal articles inserm-00378021v1
	Contribution of the kinetics of G protein dissociation to the characteristic modifications of N-type calcium channel activity. Norbert Weiss , Christophe Arnoult , Anne Feltz , Michel de Waard Neuroscience Research, 2006, 56 (3), pp.332-43. ⟨10.1016/j.neures.2006.08.002⟩ Journal articles hal-00145602v1
	Hourglass SiO2 coating increases the performance of planar patch-clamp. Thomas Sordel , Stéphanie Garnier-Raveaud , Fabien Sauter , Catherine Pudda , Frédérique Marcel Journal of Biotechnology, 2006, 125 (1), pp.142-54. ⟨10.1016/j.jbiotec.2006.02.008⟩ Journal articles inserm-00381712v1
	Triadin (Trisk 95) overexpression blocks excitation-contraction coupling in rat skeletal myotubes. Sophia Smida Rezgui , Stéphane Vassilopoulos , Julie Brocard , Jean Claude Platel , Alexandre Bouron Journal of Biological Chemistry, 2005, 280 (47), pp.39302-8. ⟨10.1074/jbc.M506566200⟩ Journal articles inserm-00381760v1
	Junctate, an inositol 1,4,5-triphosphate receptor associated protein, is present in rodent sperm and binds TRPC2 and TRPC5 but not TRPC1 channels. Séverine Stamboulian , Marie-Jo Moutin , Susan Treves , Nathalie Pochon , Didier Grunwald Developmental Biology, 2005, 286 (1), pp.326-37. ⟨10.1016/j.ydbio.2005.08.006⟩ Journal articles inserm-00380225v1
	Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion Susan Treves , Clara Franzini-Armstrong , Luca Moccagatta , Christophe Arnoult , Cristiano Grasso Journal of Cell Biology, 2004, 166 (4), pp.537-548. ⟨10.1083/jcb.200404079⟩ Journal articles hal-03884456v1

	A bimodal fluorescence and phase microscope for time-lapse imaging of 3D multi-scattering objects Chiara Paviolo , Sylvia Desissaire , Edgar del Llano , Marie Fackeure , Jeremy Neri Unconventional Optical Imaging IV, Apr 2024, Strasbourg, France. SPIE, pp.38, ⟨10.1117/12.3017387⟩ Conference poster hal-04757420v1
	3D fluorescence recovery by using a new algorithm implementing total variation regularization and the positivity constraint Lionel Hervé , Stephane Bonnet , Sylvia Desissaire , Edgar del Llano , Corinne Loeuillet Unconventional Optical Imaging IV, Apr 2024, Strasbourg, France. SPIE, pp.78, ⟨10.1117/12.3022083⟩ Conference poster hal-04757421v1
	ARMC2: a multifaceted protein involved in both flagella and cilia formation and function. Corinne Loeuillet , Elsa Giordani , Magali Court , Jessica Escoffier , Pierre F. Ray Evolution of Reproductive Sciences – Where Should We Go?, Jul 2024, Dublin, Ireland Conference poster hal-04757357v1

	3D live cell imaging of whole organoids in time-lapse using intensity diffraction tomography William Pierré , Lionel Hervé , Cédric Allier , Sophie Morales , Sergei Grudinin SPIE Photonics Europe, Apr 2022, Strasbourg, France. ⟨10.1117/12.2625734⟩ Conference papers hal-03874785v1
	Deep learning framework applied to optical diffraction tomography (ODT) William Pierré , Lionel Hervé , Cédric Allier , Sophie Morales , Sergei Grudinin Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXVIII, SPIE, Mar 2021, Online Only, France. pp.1, ⟨10.1117/12.2582361⟩ Conference papers hal-03454249v1

	Sperm fertility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA Charline Vilpreux , Guillaume Martinez , Paul Fourquin , Magali Court , Florence Appaix 2024 Preprints, Working Papers, ... hal-04757347v1
	Maternal nutritional stress alters sperm competence in male mice offspring leading to reduced fertility Yuki Muranishi , Laurent Parry , Mélanie Vachette-Dit-Martin , Fabrice Saez , Cécile Coudy-Gandilhon 2021 Preprints, Working Papers, ... hal-03434028v1

CHRISTOPHE ARNOULT

Research domains

Skills

Publications

Sperm fertility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA

Phenotypic continuum and poor intracytoplasmic sperm injection intracytoplasmic sperm injection prognosis in patients harboring HENMT1 variants

CNN-based approach for 3D artifact correction of intensity diffraction tomography images

Phenotypic continuum and poor intracytoplasmic sperm injection intracytoplasmic sperm injection prognosis in patients harboring HENMT1 variants.

Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse

A splice donor variant of GAS8 induces structural disorganization of the axoneme in sperm flagella and leads to nonsyndromic male infertility

Expanding the sperm phenotype caused by mutations in SPATA20: A novel splicing mutation in an infertile patient with partial globozoospermia

A splice donor variant of GAS8 induces structural disorganization of the axoneme in sperm flagella and leads to nonsyndromic male infertility

Genetic causes of macrozoospermia and proposal for an optimized genetic diagnosis strategy based on sperm parameters

New Mutations in DNHD1 Cause Multiple Morphological Abnormalities of the Sperm Flagella

Novel axonemal protein ZMYND12 interacts with TTC29 and DNAH1, and is required for male fertility and flagellum function

3D time-lapse imaging of a mouse embryo using intensity diffraction tomography embedded inside a deep learning framework

Combined Use of Whole Exome Sequencing and CRISPR/Cas9 to Study the Etiology of Non-Obstructive Azoospermia: Demonstration of the Dispensable Role of the Testis-Specific Genes C1orf185 and CCT6B

A recurrent ZP1 variant is responsible for oocyte maturation defect with degenerated oocytes in infertile females

Dual role of histone variant H3.3B in spermatogenesis: positive regulation of piRNA transcription and implication in X-chromosome inactivation

When idiopathic male infertility is rooted in maternal malnutrition during the perinatal period in mice

Whole-exome sequencing improves the diagnosis and care of men with non-obstructive azoospermia

Oligogenic heterozygous inheritance of sperm abnormalities in mouse

From azoospermia to macrozoospermia, a phenotypic continuum due to mutations in the ZMYND15 gene

Treatment of Mouse Sperm with a Non-Catalytic Mutant of PLA2G10 Reveals That PLA2G10 Improves In Vitro Fertilization through Both Its Enzymatic Activity and as Ligand of PLA2R1

New insights in Cercopithecinae spermatozoa

Defect in the nuclear pore membrane glycoprotein 210-like gene is associated with extreme uncondensed sperm nuclear chromatin and male infertility: a case report

The sodium/proton exchanger SLC9C1 ( sNHE ) is essential for human sperm motility and fertility

Bi-allelic truncating variants in CFAP206 cause male infertility in human and mouse

Identification and Characterization of the Most Common Genetic Variant Responsible for Acephalic Spermatozoa Syndrome in Men Originating from North Africa

A missense mutation in IFT74, encoding for an essential component for intraflagellar transport of Tubulin, causes asthenozoospermia and male infertility without clinical signs of Bardet-Biedl Syndrome

Genetic analyses of a large cohort of infertile patients with globozoospermia, DPY19L2 still the main actor, GGN confirmed as a guest player

Deslorelin acetate implant induces transient sterility and behavior changes in male olive baboon ( Papio anubis ): A case study

Pantoprazole, a proton‐pump inhibitor, impairs human sperm motility and capacitation in vitro

Genetics of teratozoospermia: Back to the head

Identification, Characterization and Synthesis of Walterospermin, a Sperm Motility Activator from the Egyptian Black Snake Walterinnesia aegyptia Venom

Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility

Paternal epigenetics: Mammalian sperm provide much more than DNA at fertilization

Biallelic variants in MAATS1 encoding CFAP91, a calmodulin-associated and spoke-associated complex protein, cause severe astheno-teratozoospermia and male infertility

Identification, Characterization and Synthesis of Walterospermin, a Sperm Motility Activator from the Egyptian Black Snake Walterinnesia aegyptia Venom

Diversity of RNA-Binding Proteins Modulating Post-Transcriptional Regulation of Protein Expression in the Maturing Mammalian Oocyte

The genetic architecture of morphological abnormalities of the sperm tail

Effects of timing of artificial insemination and treatment of semen with a Slo3 potassium channel blocker on fertility of dairy heifers subjected to the 5-day CIDR-Synch protocol

Complexity and diversity of sperm physiology

Identification, Characterization and Synthesis of Walterospermin, a Sperm Motility Activator from the Egyptian Black Snake Walterinnesia aegyptia Venom

Whole exome sequencing of men with multiple morphological abnormalities of the sperm flagella reveals novel homozygous QRICH2 mutations

Bi-allelic Mutations in ARMC2 Lead to Severe Astheno-Teratozoospermia Due to Sperm Flagellum Malformations in Humans and Mice

Enzymatic activity of mouse group X-sPLA2 improves in vitro production of preimplantation bovine embryos

Genetic causes of male infertility: snapshot on morphological abnormalities of the sperm flagellum

Mutations in TTC29, Encoding an Evolutionarily Conserved Axonemal Protein, Result in Asthenozoospermia and Male Infertility

CFAP70 mutations lead to male infertility due to severe astheno-teratozoospermia.

Whole-exome sequencing identifies mutations in FSIP2 as a recurrent cause of multiple morphological abnormalities of the sperm flagella

Échec de maturation ovocytaire

A Homozygous Ancestral SVA-Insertion-Mediated Deletion in WDR66 Induces Multiple Morphological Abnormalities of the Sperm Flagellum and Male Infertility.

PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and mice

Absence of CFAP69 Causes Male Infertility due to Multiple Morphological Abnormalities of the Flagella in Human and Mouse

Actiflagelin, a new sperm activator isolated from Walterinnesia aegyptia venom using phenotypic screening

Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in $Trypanosoma$ and human.

Homozygous missense mutation L673P in adenylate kinase 7 (AK7) leads to primary male infertility and multiple morphological anomalies of the flagella but not to primary ciliary dyskinesia

Loss of the deglutamylase CCP5 perturbs multiple steps of spermatogenesis and leads to male infertility

SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia inhomozygotes

Spermaurin, an La1-like peptide from the venom of the scorpion Scorpio maurus palmatus , improves sperm motility and fertilization in different mammalian species

Crucial Role for Immune Complexes but Not FcRn in Immunization against Anti–TNF-α Antibodies after a Single Injection in Mice

MAP6 interacts with Tctex1 and Cav 2.2/N-type calcium channels to regulate calcium signalling in neurons

Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP

Dpy19l2-deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development

Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.

Fine Characterisation of a Recombination Hotspot at the DPY19L2 Locus and Resolution of the Paradoxical Excess of Duplications over Deletions in the General Population.

Comparative testicular transcriptome of wild type and globozoospermic Dpy19l2 knock out mice

Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy.

Identification of a new recurrent Aurora kinase C mutation in both European and African men with macrozoospermia.

A new AURKC mutation causing macrozoospermia: implications for human spermatogenesis and clinical diagnosis.

Group X secreted phospholipase A₂ specifically decreases sperm motility in mice.

In vitro and in vivo intracellular delivery of quantum dots by maurocalcine

Could modifications of signalling pathways activated after ICSI induce a potential risk of epigenetic defects ?

A recurrent deletion of DPY19L2 causes infertility in man by blocking sperm head elongation and acrosome formation.

The development of high quality seals for silicon patch-clamp chips.

Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice.

Iodination increases the activity of verapamil derivatives in reversing PGP multidrug resistance.

Snake venoms as a source of compounds modulating sperm physiology: Secreted phospholipases A2 from Oxyuranus scutellatus scutellatus impact sperm motility, acrosome reaction and in vitro fertilization in mice.

Expression, localization and functions in acrosome reaction and sperm motility of Ca(V)3.1 and Ca(V)3.2 channels in sperm cells: an evaluation from Ca(V)3.1 and Ca(V)3.2 deficient mice.