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Christophe Chevalier

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Identifiants chercheurs

Présentation

**PERSONAL INFORMATION** **CHEVALIER Christophe** Male, Born December 5th 1976, in Thiais, France, French nationality *E-mail:* [*christophe.chevalier@inrae.fr*](mailto:christophe.chevalier@inrae.fr) *Web page: https://orcid.org/0000-0003-3231-9027* *Author ID: ORCID: 0000-0003-3231-9027, ResearcherID: C-2575-2009, Loop profile: 380767* • **EDUCATION** 2019 Habilitation à Diriger des Recherches, highest French academic degree allowing independent supervision of PhDs, U. Paris Saclay France 2003 PhD in Microbiology, General Virology: *Study of the morphogenesis of Infectious Bursal Disease Virus*, U. Paris 7 France. 2000 Master in General Virology, U. Lille France. 2000 Graduated of the Virology Course, Pasteur Institute, Paris, France • **CURRENT POSITION** 2020 – present Director of Research, Laboratory of Molecular Virology and Immunology, Influenza Virus Research Group, INRAE, Université Paris-Saclay, Jouy-en-Josas, France. • **PREVIOUS POSITIONS** 2010 – 2020 Research Fellow (Chargé de Recherche 1, CRCN), Laboratory of Molecular Virology and Immunology, Influenza Virus Research Group, INRAE, Jouy-en-Josas, France 2005 – 2010 Research Fellow (Chargé de Recherche 2), Laboratory of Molecular Virology and Immunology, Influenza Virus Research Group, INRAE, Jouy-en-Josas, France • **RESEARCH INTEREST** 1999 – present Molecular Biology, Virology, Structural and functional study of viral proteins, Fluorescence and electron microscopies, Development of vaccines and therapeutics 2012 – present Synchrotron Radiation Experiments (infrared spectroscopy, DUV microscopy, cryo-SXT), Multivariate data analysis 2013 – present Accreditation to animal experimentation, Animal model of infection (mice, chicken), In vivo Imaging System **• FELLOWSHIPS AND AWARDS** 2003-2005 Post-doctoral fellowship, Grant NIH – University of Texas Medical Branch (section 62553), Unit of molecular genetics in respiratory viruses – Hepatitis group, CNRS URA 1966, Pasteur Institute, Paris, France • **SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS** 2003-present supervision of 7 post-doctoral fellows, 3 PhD students (1 University Orsay, 1 University Paris 7 Denis Diderot, 1 University Paris-Saclay), 11 master students, 2 engineers. Current PhD is: 2021-2024 PhD Elise Bruder, *Study of the impact of PB1-F2 in the pathogenicity, emergence and transmissibility of influenza A viruses* (Doctoral School SDSV, University Paris-Saclay) • **TEACHING ACTIVITIES** 2011-2020 Training and accreditation of staff and students to work in biosafety level 3+ facilities 2019 Lecturer/Trainer Host-Pathogen Interactions, Factor of Virulence of Influenza Viruses, University Paris-Saclay, France (3 weeks) 2010-2012 Lecturer, “Influenza Viruses: Structure and Function of the viral proteins”, Veterinary school of Maisons-Alfort, France 2009 Lecturer, “Viral Pseudo and Nanoparticles, new application”, Faculty of Pharmacy, Châtenay-Malabry, France • **INSTITUTIONAL RESPONSIBILITIES** 2011 – present Responsible of the Biosafety Level 3+ biocontainment facility of the laboratory of Molecular Virology and Immunology (Influenza Virus, Hepatitis C Virus, Sars-Cov2…), INRAE, Jouy-en-Josas, France 2017 – present Member of the users’ scientific committee at the synchrotron SOLEIL, Saint-Aubin, France • **REVIEWING AND EDITORIAL ACTIVITIES** 2003 – present Peer Reviewer for 20+ international journals in virology and microbiology 2017 – 2020 Guest Associate Editor, *Frontiers in Immunology* 2018 – present Review Editor, *Frontiers in Microbiology,* Infectious Agents and Disease 2017 – present Member of the Editorial Board, of *Vaccines* and *Pathogens,* MDPI • **MEMBERSHIPS OF SCIENTIFIC SOCIETIES** 2018 – present Founder and Board Member of the French Influenza Virus research Network (resaFLU) and chairman of the “physiopathology of infection” research axis. Organization of meeting (2019, Lyon, France, ~100 attendees) and webinars (3/years). Webmaster (website in construction <https://gdr.resaflu.prod.lamp.cnrs.fr/>) • **MAJOR COLLABORATIONS** 2010 – 2014 Dr. Hafsa Korri-Youssoufi, Institut de Chimie Moléculaire et des matériaux, Université d’Orsay, France 2011 – present Dr. Frederic Jamme, DISCO beamline, Synchrotron SOLEIL, Saint-Aubin, France 2014 – present Pr. Denis Archambault et Pr. Steve Bourgault, Université du Québec à Montréal, Canada 2018 – present Dr. Eva Pereiro, MISTRAL Beamline, Synchrotron ALBA, Cerdanyola del Vallès, Barcelona, Spain

Publications

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Comparison of PB1-F2 Proximity Interactomes Reveals Functional Differences between a Human and an Avian Influenza Virus

Joëlle Mettier , Clémentine Prompt , Elise Bruder , Bruno da Costa , Christophe Chevalier
Viruses, 2023, 15 (2), pp.328. ⟨10.3390/v15020328⟩
Article dans une revue hal-04023221v1

L’autonomie dans l’invisibilité. Les accompagnantes des élèves en situation de handicap

Christophe Chevalier , Alicia Jacquot , Arthur Imbert
Nouvelle Revue du travail, 2022, 20, ⟨10.4000/nrt.11418⟩
Article dans une revue hal-03665980v1
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Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein

Antoine Guillon , Deborah Bréa-Diakite , Adeline Cezard , Alan Wacquiez , Thomas Baranek
EMBO Journal, 2022, 41 (12), pp.e108306. ⟨10.15252/embj.2021108306⟩
Article dans une revue hal-03687124v2

Self-assembled peptide nanorod vaccine confers protection against influenza A virus

Ximena Zottig , Soultan Al-Halifa , Mélanie Côté-Cyr , Cynthia Calzas , Ronan Le Goffic
Article dans une revue hal-03319841v1
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PB1-F2 amyloid-like fibers correlate with proinflammatory signaling and respiratory distress in influenza-infected mice

Christophe Chevalier , Olivier Leymarie , Laura Sedano , Bruno da Costa , Charles-Adrien Richard
Journal of Biological Chemistry, 2021, 297 (1), ⟨10.1016/j.jbc.2021.100885⟩
Article dans une revue hal-03299147v1
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Study of the host specificity of PB1-F2-associated virulence

Joëlle Mettier , Daniel Marc , Laura Sedano , Bruno da Costa , Christophe Chevalier
Virulence, 2021, 12 (1), pp.1647 - 1660. ⟨10.1080/21505594.2021.1933848⟩
Article dans une revue hal-03264952v1
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Immunogenicity and Protective Potential of Mucosal Vaccine Formulations Based on Conserved Epitopes of Influenza A Viruses Fused to an Innovative Ring Nanoplatform in Mice and Chickens

Cynthia Calzas , Molida Mao , Mathilde Turpaud , Quentin Viboud , Joelle Mettier
Frontiers in Immunology, 2021, 12, ⟨10.3389/fimmu.2021.772550⟩
Article dans une revue hal-03575999v1
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Influenza viruses and coronaviruses: Knowns, unknowns, and common research challenges

Olivier Terrier , Mustapha Si-Tahar , Mariette Ducatez , Christophe Chevalier , Andrés Pizzorno
PLoS Pathogens, 2021, 17 (12), pp.e1010106. ⟨10.1371/journal.ppat.1010106⟩
Article dans une revue hal-03518306v1
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Impact of the influenza protein PB1-F2 on the biochemical composition of human epithelial cells revealed by synchrotron Fourier transform infrared spectromicroscopy

Olivier Leymarie , Ronan Le Goffic , Frederic Jamme , Christophe Chevalier
Journal of Spectral Imaging, 2020, 8 (18), ⟨10.1255/jsi.2019.a18⟩
Article dans une revue hal-02873862v1
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Innovative mucosal vaccine formulations against Influenza a virus Infections

Christophe Chevalier , Cynthia Calzas
Frontiers in Immunology, 2019, pp.1-21. ⟨10.3389/fimmu.2019.01605⟩
Article dans une revue hal-02619967v1
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Editorial: Innovative Therapeutic and Vaccine Approaches Against Respiratory Pathogens

Cynthia Calzas , Delphyne Descamps , Michel Chignard , Christophe Chevalier
Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.02960⟩
Article dans une revue hal-02943195v1
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Transcriptomic profiling of a chicken lung epithelial cell line (CLEC213) reveals a mitochondrial respiratory chain activity boost during influenza virus infection

Léa Meyer , Olivier Leymarie , Christophe Chevalier , Evelyne Esnault , Marco Moroldo
PLoS ONE, 2017, 12 (4), 18 p. ⟨10.1371/journal.pone.0176355⟩
Article dans une revue hal-01605882v1
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The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin

Charlotte Deloizy , Even Fossum , Christophe Barnier-Quer , Celine Urien , Tiphany Chrun
Scientific Reports, 2017, 7, ⟨10.1038/s41598-017-07372-9⟩
Article dans une revue hal-02626640v1

Influenza virus protein PB1-F2 interacts with CALCOCO2 (NDP52) to modulate innate immune response

Olivier Leymarie , Léa Meyer , Lionel Tafforeau , Vincent Lotteau , Bruno da Costa
Journal of General Virology, 2017, 98 (6), pp.1196-1208. ⟨10.1099/jgv.0.000782⟩
Article dans une revue hal-01911416v1
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Host response comparison of H1N1-and H5N1-infected mice identifies two potential death mechanisms

Olivier Leymarie , Léa Meyer , Pierre Louis Herve , Bruno da Costa , Bernard Delmas
International Journal of Molecular Sciences, 2017, 18 (8), ⟨10.3390/ijms18081631⟩
Article dans une revue hal-02617657v1
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Corrigendum: A Universal Influenza Vaccine Can Lead to Disease Exacerbation or Viral Control Depending on Delivery Strategies

Cindy Bernelin-Cottet , Charlotte Deloizy , Ondrej Stanek , Céline Barc , Edwige Bouguyon
Frontiers in Immunology, 2017, 8, pp.831. ⟨10.3389/fimmu.2017.00831⟩
Article dans une revue hal-02618722v1
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Amyloid assemblies of influenza a virus PB1-F2 protein Damage membrane and induce cytotoxicity

Jasmina Vidic , Charles-Adrien Richard , Christine Péchoux , Bruno B. da Costa , Nicolas N. Bertho
Journal of Biological Chemistry, 2016, 291 (2), pp.739-751. ⟨10.1074/jbc.M115.652917⟩
Article dans une revue hal-02637618v1
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The Influenza Virus Protein PB1-F2 Increases Viral Pathogenesis through Neutrophil Recruitment and NK Cells Inhibition

Aurore Vidy-Roche , Pauline Maisonnasse , Bruno da Costa , Bernard Delmas , Christophe Chevalier
PLoS ONE, 2016, 11 (10), pp.1-19. ⟨10.1371/journal.pone.0165361⟩
Article dans une revue hal-01608535v1
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A Universal Influenza Vaccine Can Lead to Disease Exacerbation or Viral Control Depending on Delivery Strategies

Cindy Bernelin-Cottet , Charlotte Deloizy , Ondrej Stanek , Céline Barc , Edwige Bouguyon
Frontiers in Immunology, 2016, 8, pp.1-1. ⟨10.3389/fimmu.2016.00641⟩
Article dans une revue hal-01569908v1

N-terminal domain of PB1-F2 protein of influenza A virus can fold into amyloid-like oligomers and damage cholesterol and cardiolipid containing membranes

Dalila Ajjaji , Charles-Adrien Richard , Sandra Mazerat , Christophe Chevalier , Jasmina Vidic
Biochemical and Biophysical Research Communications, 2016, 477 (1), pp.27-32. ⟨10.1016/j.bbrc.2016.06.016⟩
Article dans une revue hal-02636639v1
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Synchrotron Infrared and Deep UV Fluorescent Microspectroscopy Study of PB1-F2 β-Aggregated Structures in Influenza A Virus-infected Cells

Christophe Chevalier , Ronan Le Goffic , Frédéric Jamme , Olivier Leymarie , Matthieu Réfrégiers
Journal of Biological Chemistry, 2016, 291 (17), pp.9060 - 9072. ⟨10.1074/jbc.M115.710533⟩
Article dans une revue hal-01724147v1
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The respiratory DC/macrophage network at steady-state and upon influenza infection in the swine biomedical model

P Maisonnasse , E Bouguyon , G Piton , A Ezquerra , Céline Urien
Mucosal Immunology, 2015, 9 (4), pp.835 - 849. ⟨10.1038/mi.2015.105⟩
Article dans une revue hal-03576019v1

Direct electrochemical detection of PB1-F2 protein of influenza A virus in infected cells

Anna Miodek , Helene Sauriat-Dorizon , Christophe Chevalier , Bernard B. Delmas , Jasmina Vidic
Biosensors and Bioelectronics, 2014, 59, pp.6-13. ⟨10.1016/j.bios.2014.02.037⟩
Article dans une revue hal-02635315v1

A Novel Subnucleocapsid Nanoplatform for Mucosal Vaccination against Influenza Virus That Targets the Ectodomain of Matrix Protein 2

Pierre-Louis Hervé , Mariam Raliou , Christiane Bourdieu , Catherine C. Dubuquoy , Agnes Petit-Camurdan
Journal of Virology, 2014, 88 (1), pp.325-338. ⟨10.1128/JVI.01141-13⟩
Article dans une revue hal-02637841v1
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Effects of Water and Cell Culture Media on the Physicochemical Properties of ZnMgO Nanoparticles and Their Toxicity toward Mammalian Cells

Jasmina Vidic , Francia Haque , Jean Michel Guigner , Aurore Vidy , Christophe Chevalier
Langmuir, 2014, 30 (38), pp.11366 - 11374. ⟨10.1021/la501479p⟩
Article dans une revue hal-03576027v1

Electrochemical Detection of the Oligomerization of PB1-F2 Influenza A Virus Protein in Infected Cells

Anna Miodek , Jasmina Vidic , Helene Sauriat-Dorizon , Charles-Adrien Richard , Ronan Le Goffic
Analytical Chemistry, 2014, 86 (18), pp.9098 - 9105. ⟨10.1021/ac5018056⟩
Article dans une revue hal-02635306v1
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PB1-F2 attenuates virulence of highly pathogenic avian H5N1 influenza virus in chickens

Olivier Leymarie , Carissa Embury-Hyatt , Christophe Chevalier , Luc Jouneau , Marco Moroldo
PLoS ONE, 2014, 9 (6), ⟨10.1371/journal.pone.0100679⟩
Article dans une revue hal-01194021v1

Shadoo binds lipid membranes and undergoes aggregation and fibrillization

Qiaojing Li , Christophe Chevalier , Celine C. Henry , Charles-Adrien Richard , Mohammed M. Moudjou
Biochemical and Biophysical Research Communications, 2013, 438 (3), pp.519 - 525. ⟨10.1016/j.bbrc.2013.07.104⟩
Article dans une revue hal-02643069v1

Identification of One Novel Candidate Probiotic Lactobacillus plantarum Strain Active against Influenza Virus Infection in Mice by a Large-Scale Screening

Noura N. Kechaou , Florian F. Chain , Jean-Jacques J.-J. Gratadoux , Sebastien S. Blugeon , Nicolas N. Bertho
Applied and Environmental Microbiology, 2013, 79 (5), pp.1491 - 1499. ⟨10.1128/AEM.03075-12⟩
Article dans une revue hal-01001569v1
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Detection of soluble oligomers formed by PB1-F2 influenza A virus protein in vitro

Jasmina Vidic , Ronan Le Goffic , Anna Miodek , Christiane Bourdieu , Charles-Adrien Richard
Journal of Analytical & Bioanalytical Techniques, 2013, 4 (3), pp.1-2. ⟨10.4172/2155-9872.1000169⟩
Article dans une revue hal-02642907v1
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Surface plasmon resonance immunosensor for detection of pb1-f2 influenza a virus protein in infected biological samples

Jasmina Vidic , Christophe Chevalier , Ronan Le Goffic , Anna Miodek , Christiane Bourdieu
Journal of Analytical & Bioanalytical Techniques, 2013, S7, ⟨10.4172/2155-9872.S7-006⟩
Article dans une revue hal-02642777v1
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Kinetic characterization of PB1-F2-mediated immunopathology during highly pathogenic avian H5N1 influenza virus infection.

Olivier O. Leymarie , Gregory G. Jouvion , Pierre-Louis P.-L. Hervé , Christophe Chevalier , Valérie V. Lorin
PLoS ONE, 2013, 8 (3), pp.e57894. ⟨10.1371/journal.pone.0057894⟩
Article dans une revue hal-01004085v1

Oligomerization paths of the nucleoprotein of influenza A virus

Bogdan Tarus , Olivier Bakowiez , Sophie Chenavas , Lucie Duchemin , L.F. Estrozi
Biochimie, 2012, 94 (3), pp.776-785
Article dans une revue hal-02650463v1
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Molecular dynamics studies of the nucleoprotein of influenza A virus: role of the protein flexibility in RNA binding

Bogdan Tarus , Christophe Chevalier , Charles-Adrien Richard , Bernard B. Delmas , Carmelo Di Primo
PLoS ONE, 2012, 7 (1), pp.e30038. ⟨10.1371/journal.pone.0030038⟩
Article dans une revue hal-02647086v1
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Transcriptomic analysis of host immune and cell death responses associated with the influenza A virus PB1-F2 protein.

Ronan Le Goffic , Olivier Leymarie , Christophe Chevalier , Emmanuelle Rebours , Bruno da Costa
PLoS Pathogens, 2011, 7 (8), pp.e1002202. ⟨10.1371/journal.ppat.1002202⟩
Article dans une revue hal-00684735v1
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PB1-F2 Influenza A Virus Protein Adopts a beta-Sheet Conformation and Forms Amyloid Fibers in Membrane Environments

Christophe Chevalier , Ali Al Bazzal , Jasmina Vidic , Vincent Fevrier , Christiane Bourdieu
Journal of Biological Chemistry, 2010, 285 (17), pp.13233-13243. ⟨10.1074/jbc.M109.067710⟩
Article dans une revue hal-02664783v1

Influenza A Virus Protein PB1-F2 Exacerbates IFN-b Expression of Human Respiratory Epithelial Cells

Ronan Le Goffic , Edwige Bouguyon , Christophe Chevalier , Jasmina Vidic , Bruno da Costa
Journal of Immunology, 2010, 185 (8), pp.4812-4823. ⟨10.4049/jimmunol.0903952⟩
Article dans une revue hal-01193647v1

Crystal Structure of an Aquabirnavirus Particle: Insights into Antigenic Diversity and Virulence Determinism

Fasséli Coulibaly , Christophe Chevalier , Bernard Delmas , Félix A Rey
Journal of Virology, 2009, 84 (4), pp.1792 - 1799. ⟨10.1128/jvi.01536-09⟩
Article dans une revue hal-03573503v1
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Inhibition of Hepatitis C Virus Infection in Cell Culture by Small Interfering RNAs.

Christophe Chevalier , Aure Saulnier , Yann Benureau , Dorian Fléchet , David Delgrange
Molecular Therapy, 2007, 15 (8), pp.1452-62. ⟨10.1038/sj.mt.6300186⟩
Article dans une revue pasteur-00166450v1

Les relations structurales entre birnavirus et autres virus icosaédriques à ARN

Fasseli Coulibaly , Christophe Chevalier , Marie Galloux , Bruno da Costa , Jean Lepault
Virologie, 2006, 10 (3), pp.233-235
Article dans une revue hal-02655894v1
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Structure of birnavirus-like particles determined by combined electron cryomicroscopy and X-ray crystallography

Joan Pous , Christophe Chevalier , Malika Ouldali , Jorge Navaza , Bernard Delmas
Journal of General Virology, 2005, 86, pp.2339 - 2346. ⟨10.1099/vir.0.80942-0⟩
Article dans une revue hal-03573442v1

The Birnavirus Crystal Structure Reveals Structural Relationships among Icosahedral Viruses

Fasséli Coulibaly , Christophe Chevalier , Irina Gutsche , Joan Pous , Jorge Navaza
Cell, 2005, 120 (6), pp.761-772. ⟨10.1016/j.cell.2005.01.009⟩
Article dans une revue hal-03573434v1
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Structural Peptides of a Nonenveloped Virus Are Involved in Assembly and Membrane Translocation

Christophe Chevalier , Marie Galloux , Joan Pous , Céline Henry , Jérôme Denis
Journal of Virology, 2005, 79, pp.12253 - 12263. ⟨10.1128/jvi.79.19.12253-12263.2005⟩
Article dans une revue hal-03573462v1

Structure of birnavirus-like particles determined by combined electron cryomicroscopy and X-ray crystallography

Joan Pous , Christophe Chevalier , Malika Ouldali , Jorge Navaza , Bernard B. Delmas
Journal of General Virology, 2005, 86 (8), pp.2339-20346. ⟨10.1099/vir.0.80942-0⟩
Article dans une revue hal-02681514v1

Structural Peptides of a Nonenveloped Virus Are Involved in Assembly and Membrane Translocation

Christophe Chevalier , Marie Galloux , Joan Pons , Celine C. Henry , Bruno da Costa
Journal of Virology, 2005, 79 (19), pp.12253-12263. ⟨10.1128/JVI.79.19.12253-12263.2005⟩
Article dans une revue hal-02683022v1

The birnavirus crystal structure reveals structural relationships among icosahedral viruses

Fasseli Coulibaly , Christophe Chevalier , Irina Gutsche , Joan Pous , Jorge Navaza
Cell, 2005, 120 (6), pp.761-772. ⟨10.1016/j.cell.2005.01.009⟩
Article dans une revue hal-02683425v1

Peptides resulting from the pVP2 C-terminal processing are present in infectious pancreatic necrosis virus particles

Marie Galloux , Christophe Chevalier , Celine C. Henry , Jean-Claude Huet , Bruno B. da Costa
Journal of General Virology, 2004, 85 (8), pp.2231-2236. ⟨10.1099/vir.0.80012-0⟩
Article dans une revue hal-02683321v1

The last C-terminal residue of VP3, glutamic acid 257, controls capsid assembly of infectious bursal disease virus

Christophe Chevalier , Jean Lepault , Bruno B. da Costa , Bernard B. Delmas
Journal of Virology, 2004, 78 (7), pp.3296-3303. ⟨10.1128/JVI.78.7.3296-3303.2004⟩
Article dans une revue hal-02682913v1

Avian adenovirus CELO recombinants expressing VP2 of infectious bursal disease virus induce protection against bursal disease in chickens

Achille François , Christophe Chevalier , Bernard B. Delmas , Nicolas Eterradossi , Didier Toquin
Vaccine, 2004, 22 (17-18), pp.2351-2360. ⟨10.1016/j.vaccine.2003.10.039⟩
Article dans une revue hal-02680360v1

Blotched snakehead virus is a new aquatic birnavirus that is slightly more related to avibirnavirus than to aquabirnavirus

Bruno da Costa , S. Soignier , Christophe Chevalier , C. Henry , C. Thory
Journal of Virology, 2003, 77 (1), pp.719-725. ⟨10.1128/JVI.77.1.719-725.2003⟩
Article dans une revue hal-02675513v1

Contraindre les protéines de capside de birnavirus à s'autoassembler en pseudo-particules

Christophe Chevalier , Inge Erk , Bruno da Costa , Jean Lepault , Bernard Delmas
Virologie, 2002, 6 (2), pp.132-134
Article dans une revue hal-02676375v1

The capsid of infectious bursal disease virus contains several small peptides arising from the maturation process of pVP2

Bruno da Costa , Christophe Chevalier , C. Henry , J.C. Huet , S. Petit
Journal of Virology, 2002, 76 (5), pp.2393-2402. ⟨10.1128/JVI.76.5.2393-2402.2002⟩
Article dans une revue hal-02678629v1