Christos Chadjichristos

Documents

Publications

From haemodynamics to kidney risk: AI-based early prediction validated in general and burn ICU populations

Louis Boutin , Fedi Kadri , Arij Chaftar , Benjamin Deniau , Sakura Minani et al.

European Heart Journal - Digital Health, 2026, 7 (1), pp.ztaf150. ⟨10.1093/ehjdh/ztaf150⟩

Article dans une revue hal-05476878v1

Loss of NGAL protects against albumin-induced kidney inflammation and fibrosis

Stefanny Figueroa , Javier Reyes Osorio , Safia Hadjadj , Gabriela Arenas , Patricio Araos et al.

Renal Failure, 2026, 48 (1), ⟨10.1080/0886022X.2026.2642530⟩

Article dans une revue hal-05589000v1

Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny Figueroa , Siyi Huang , Javier Reyes Osorio , Jean-Jacques Boffa , Cristián Amador et al.

International Journal of Molecular Medicine, 2026, 58 (2), pp.1-21. ⟨10.3892/ijmm.2026.5881⟩

Article dans une revue hal-05794582v1

Fibroblast‐derived neuropilin 1 alleviates renal fibrosis progression

Yunzhu Shen , Sandrine Placier , Liliane Louedec , Perrine Frère , Sophie Vandermeersch et al.

Journal of Pathology, 2025, Online ahead of print. ⟨10.1002/path.70009⟩

Article dans une revue hal-05440957v1

Postoperative subclinical AKI is frequent and is linked to a poor long-term prognosis in critically ill patients

Louis Boutin , Christos Chadjichristos , Alexandre Mebazaa , François Dépret

Indian Journal of Anaesthesia, 2025, 69 (7), pp.736-738. ⟨10.4103/ija.ija_207_25⟩

Article dans une revue hal-05172089v1

Progression of Kidney Fibrosis after Sepsis: The Underestimated Role of Resident Macrophages and Recruited Monocytes

Charles de Roquetaillade , Manon Durand , Victor Beaucoté , Jérémie Guillemin , Christos Evangelos Chadjichristos et al.

Journal of the American Society of Nephrology, 2025, Online ahead of print. ⟨10.1681/ASN.0000000712⟩

Article dans une revue inserm-05075620v1

Galectin-3/CD146 interaction promotes renal damage and systemic inflammation after acute kidney injury

Louis Boutin , S. Figueroa , Elise Roger , S. Hadjadj , Rémi Piedagnel et al.

Scientific Reports, 2025, 15 (1), pp.41575. ⟨10.1038/s41598-025-25477-4⟩

Article dans une revue hal-05390998v1

The role of CD146 in renal disease: from experimental nephropathy to clinics

Louis Boutin , Elena Roger , Etienne Gayat , François Depret , Marcel Blot-Chabaud et al.

Journal of Molecular Medicine, 2024, 102 (1), pp.113-128. ⟨10.1007/s00109-023-02392-7⟩

Article dans une revue hal-04401078v1

Endothelial-specific deletion of connexin 43 improves renal function and structure after acute kidney injury

Magali Genest , Satoshi Kinugasa , Elena Roger , Louis Boutin , Sandrine Placier et al.

Molecular Medicine, 2024, 30 (1), pp.261. ⟨10.1186/s10020-024-01011-6⟩

Article dans une revue hal-04853992v1

Endothelial-specific deletion of connexin 43 improves renal function and structure after acute kidney injury

Magali Genest , Satoshi Kinugasa , Elena Roger , Louis Boutin , Sandrine Placier et al.

Molecular Medicine, 2024, 30 (1), pp.261. ⟨10.1186/s10020-024-01011-6⟩

Article dans une revue hal-05771198v1

The Angiogenesis Inhibitor Isthmin-1 (ISM1) Is Overexpressed in Experimental Models of Glomerulopathy and Impairs the Viability of Podocytes

Virgilia Sahiri , Jonathan Caron , Elena Roger , Christophe Desterke , Khalil Ghachem et al.

International Journal of Molecular Sciences, 2023, 24 (3), pp.2723. ⟨10.3390/ijms24032723⟩

Article dans une revue hal-04023018v1

Subclinical and clinical acute kidney injury share similar urinary peptide signatures and prognosis

Louis Boutin , Agnieszka Latosinska , Harald Mischak , Benjamin Deniau , Ayu Asakage et al.

Intensive Care Medicine, 2023, 49 (10), pp.1191-1202. ⟨10.1007/s00134-023-07198-2⟩

Article dans une revue inserm-05464578v1

Genetic inactivation of Semaphorin 3C protects mice from acute kidney injury

Anxiang Cai , Guanyu Ye , Sandrine Placier , Perrine Frère , Brigitte Surin et al.

Kidney International, 2022, 101 (4), pp.720-732. ⟨10.1016/j.kint.2021.12.028⟩

Article dans une revue inserm-03665154v1

The Role of Connexin 43 in Renal Disease: Insights from In Vivo Models of Experimental Nephropathy

Elena Roger , Louis Boutin , Christos Chadjichristos

International Journal of Molecular Sciences, 2022, 23 (21), pp.13090. ⟨10.3390/ijms232113090⟩

Article dans une revue hal-03891976v1

Deletion of Notch3 Impairs Contractility of Renal Resistance Vessels Due to Deficient Ca2+ Entry

Frank Helle , Michael Hultström , Panagiotis Kavvadas , Bjarne Iversen , Christos E Chadjichristos et al.

International Journal of Molecular Sciences, 2022, 23 (24), pp.16068. ⟨10.3390/ijms232416068⟩

Article dans une revue hal-03922921v1

Elevated plasma Galectin-3 is associated with major adverse kidney events and death after ICU admission

Louis Boutin , Matthieu Legrand , Malha Sadoune , Alexandre Mebazaa , Etienne Gayat et al.

Critical Care, 2022, 26 (1), pp.13. ⟨10.1186/s13054-021-03878-x⟩

Article dans une revue hal-03518948v1

Galectin-3 in Kidney Diseases: From an Old Protein to a New Therapeutic Target

Louis Boutin , François Dépret , Etienne Gayat , Matthieu Legrand , Christos Chadjichristos

International Journal of Molecular Sciences, 2022, 23 (6), pp.3124. ⟨10.3390/ijms23063124⟩

Article dans une revue hal-03838218v1

Connexin 43: A Target for the Treatment of Inflammation in Secondary Complications of the Kidney and Eye in Diabetes

Chelsy L Cliff , Bethany M Williams , Christos E Chadjichristos , Ulrik Mouritzen , Paul E Squires et al.

International Journal of Molecular Sciences, 2022, 23 (2), pp.600. ⟨10.3390/ijms23020600⟩

Article dans une revue hal-03557450v1

Super‐resolved local recruitment of CLDN5 to filtration slits implicates a direct relationship with podocyte foot process effacement

Florian Tesch , Florian Siegerist , Eleonora Hay , Nadine Artelt , Christoph Daniel et al.

Journal of Cellular and Molecular Medicine, 2021, 25 (16), pp.7631-7641. ⟨10.1111/jcmm.16519⟩

Article dans une revue hal-03268855v1

Endothelial-Specific Deletion of CD146 Protects Against Experimental Glomerulonephritis in Mice

Ahmed Abed , Aurélie Leroyer , Panagiotis Kavvadas , Florence Authier , Richard Bachelier et al.

Hypertension, 2021, 77 (4), pp.1260-1272. ⟨10.1161/HYPERTENSIONAHA.119.14176⟩

Article dans une revue hal-03226402v2

Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease

Gareth Price , Christos Chadjichristos , Panagiotis Kavvadas , Sydney Tang , Wai Han Yiu et al.

Cell Communication and Signaling, 2020, 18 (1), pp.79. ⟨10.1186/s12964-020-00558-1⟩

Article dans une revue hal-03838304v1

Periostin Promotes Cell Proliferation and Macrophage Polarization to Drive Repair after AKI

Raphaёl Kormann , Panagiotis Kavvadas , Sandrine Placier , Sophie Vandermeersch , Aude Dorison et al.

Journal of the American Society of Nephrology, 2020, 31 (1), pp.85-100. ⟨10.1681/ASN.2019020113⟩

Article dans une revue hal-02494252v1

Notch3 orchestrates epithelial and inflammatory responses to promote acute kidney injury

Panagiotis Kavvadas , Zela Keuylian , Niki Prakoura , Sandrine Placier , Aude Dorison et al.

Kidney International, 2018, 94 (1), pp.126-138. ⟨10.1016/j.kint.2018.01.031⟩

Article dans une revue hal-03838330v1

The Role of Palladin in Podocytes

Nadine Artelt , Tim Ludwig , Henrik Rogge , Panagiotis Kavvadas , Florian Siegerist et al.

Journal of the American Society of Nephrology, 2018, 29 (6), pp.1662-1678. ⟨10.1681/ASN.2017091039⟩

Article dans une revue hal-03838331v1

Decreased Expression of Connexin 43 Blunts the Progression of Experimental GN

Panagiotis Kavvadas , Ahmed Abed , Coralie Poulain , Florence Authier , Lise-Paule Labéjof et al.

Journal of the American Society of Nephrology, 2017, 28 (10), pp.2915-2930. ⟨10.1681/ASN.2016111211⟩

Article dans une revue hal-03838334v1

Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases

Eleni Arvaniti , Panagiotis Moulos , Athina Vakrakou , Christos Chatziantoniou , Christos Chadjichristos et al.

Scientific Reports, 2016, 6 (1), pp.26235. ⟨10.1038/srep26235⟩

Article dans une revue hal-03838355v1

NF κ B-Induced Periostin Activates Integrin- β 3 Signaling to Promote Renal Injury in GN

Niki Prakoura , Panagiotis Kavvadas , Raphaёl Kormann , Jean-Claude Dussaule , Christos Chadjichristos et al.

Journal of the American Society of Nephrology, 2016, 28 (5), pp.1475 - 1490. ⟨10.1681/ASN.2016070709⟩

Article dans une revue hal-01528800v1

Functional roles of connexins and pannexins in the kidney

Ahmed Abed , Panagiotis Kavvadas , Christos Chadjichristos

Cellular and Molecular Life Sciences, 2015, 72 (15), pp.2869-2877. ⟨10.1007/s00018-015-1964-5⟩

Article dans une revue hal-03838371v1

Discoidin domain receptor-1 and periostin: new players in chronic kidney disease

Carlo Alfieri , Panagiotis Kavvadas , Paola Simonini , Masami Ikehata , Jean Claude Dussaule et al.

Nephrology Dialysis Transplantation, 2015, 30 (12), pp.1965-1971. ⟨10.1093/ndt/gfv074⟩

Article dans une revue hal-03838393v1

Targeting connexin 43 protects against the progression of experimental chronic kidney disease in mice

Ahmed Abed , Julie Toubas , Panagiotis Kavvadas , Florence Authier , Dominique Cathelin et al.

Kidney International, 2014, 86 (4), pp.768-779. ⟨10.1038/ki.2014.108⟩

Article dans une revue hal-03838395v1

Connexins in Renal Endothelial Function and Dysfunction

Ahmed Abed , Jean-Claude Dussaule , Jean-Jacques Boffa , Christos Chatziantoniou , Christos Chadjichristos

Cardiovascular and Hematological Disorders - Drug Targets, 2014, 14 (1), pp.15-21. ⟨10.2174/1871529x14666140401105827⟩

Article dans une revue hal-03838401v1

Progression of renal fibrosis: the underestimated role of endothelial alterations

Dominique Guerrot , Jean-Claude Dussaule , Panagiotis Kavvadas , Jean-Jacques Boffa , Christos Chadjichristos et al.

Fibrogenesis and Tissue Repair, 2012, 5 (S1), pp.S15. ⟨10.1186/1755-1536-5-S1-S15⟩

Article dans une revue hal-03838410v1

The RenTg Mice: A Powerful Tool to Study Renin-Dependent Chronic Kidney Disease

Anne-Cecile Huby , Panagiotis Kavvadas , Carlo Alfieri , Ahmed Abed , Julie Toubas et al.

PLoS ONE, 2012, 7 (12), pp.e52362. ⟨10.1371/journal.pone.0052362⟩

Article dans une revue hal-03838404v1

Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes

Emmanuelle Renard , Benoît Porée , Christos Chadjichristos , Magdalini Kypriotou , Laure Maneix et al.

Journal of Molecular Medicine, 2012, 90 (6), pp.649-666. ⟨10.1007/s00109-011-0842-3⟩

Article dans une revue istex hal-03838419v1

Progression of renal fibrosis: the underestimated role of endothelial alterations

Dominique Guerrot , Jean-Claude Dussaule , Panagiotis Kavvadas , Jean-Jacques Boffa , Christos Chadjichristos et al.

Fibrogenesis & Tissue Repair, 2012, 5 (Suppl 1), pp.S15

Article dans une revue inserm-00704841v1

The role of cell plasticity in progression and reversal of renal fibrosis

Jean-Claude Dussaule , Dominique Guerrot , Anne-Cécile Huby , Christos Chadjichristos , Nasim Shweke et al.

International Journal of Experimental Pathology, 2011, 92 (3), pp.151-157. ⟨10.1111/j.1365-2613.2011.00760.x⟩

Article dans une revue hal-03838428v1

Alteration of connexin expression is an early signal for chronic kidney disease

Julie Toubas , Samantha Beck , Anne-Laure Pageaud , Anne-Cecile Huby , Mouna Mael-Ainin et al.

American Journal of Physiology. Renal Physiology, 2011, 301 (1), pp.F24-F32. ⟨10.1152/ajprenal.00255.2010⟩

Article dans une revue hal-03838425v1

Improvement of renal hemodynamics during hypertension-induced chronic renal disease: role of EGF receptor antagonism

Frank Helle , Charlotte Jouzel , Christos Chadjichristos , Sandrine Placier , Martin Flamant et al.

American Journal of Physiology. Renal Physiology, 2009, 297 (1), pp.F191-F199. ⟨10.1152/ajprenal.00015.2009⟩

Article dans une revue hal-03838442v1

Molecular role of Cx37 in advanced atherosclerosis: A micro-array study

Jean-Paul Derouette , Cindy Wong , Laurent Burnier , Sandrine Morel , Esther Sutter et al.

Atherosclerosis, 2009, 206 (1), pp.69-76. ⟨10.1016/j.atherosclerosis.2009.02.020⟩

Article dans une revue istex hal-03838448v1

Interleukin-1 and Transforming Growth Factor-ß 1 as Crucial Factors in Osteoarthritic Cartilage Metabolism

Jean-Pierre Pujol , Christos Chadjichristos , Florence Legendre , Catherine Baugé , Gallic Beauchef et al.

Connective Tissue Research, 2009, 49 (3-4), pp.293-297. ⟨10.1080/03008200802148355⟩

Article dans une revue hal-03838453v1

Connexins: New genes in atherosclerosis

Christos Chadjichristos , Brenda Kwak

Annals of Medicine, 2009, 39 (6), pp.402-411. ⟨10.1080/07853890701436757⟩

Article dans une revue hal-03838471v1

Interleukin-6 (IL-6) and/or Soluble IL-6 Receptor Down-regulation of Human Type II Collagen Gene Expression in Articular Chondrocytes Requires a Decrease of Sp1·Sp3 Ratio and of the Binding Activity of Both Factors to the COL2A1 Promoter

Benoît Porée , Magdalini Kypriotou , Christos Chadjichristos , Gallic Beauchef , Emmanuelle Renard et al.

Journal of Biological Chemistry, 2008, 283 (8), pp.4850-4865. ⟨10.1074/jbc.M706387200⟩

Article dans une revue hal-03838464v1

Targeting Connexin 43 Prevents Platelet-Derived Growth Factor-BB–Induced Phenotypic Change in Porcine Coronary Artery Smooth Muscle Cells

Christos Chadjichristos , Sandrine Morel , Jean-Paul Derouette , Esther Sutter , Isabelle Roth et al.

Circulation Research, 2008, 102 (6), pp.653-660. ⟨10.1161/CIRCRESAHA.107.170472⟩

Article dans une revue hal-03838462v1

Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-β pathway - implication of C-Krox and Sp1

Emmanuelle Renard , Christos Chadjichristos , Magdalini Kypriotou , Gallic Beauchef , Pascal Bordat et al.

Journal of Cellular and Molecular Medicine, 2008, 12 (6b), pp.2836-2847. ⟨10.1111/j.1582-4934.2008.00287.x⟩

Article dans une revue hal-03838458v1

Human Collagen Krox Up-regulates Type I Collagen Expression in Normal and Scleroderma Fibroblasts through Interaction with Sp1 and Sp3 Transcription Factors

Magdalini Kypriotou , Gallic Beauchef , Christos Chadjichristos , Russell Widom , Emmanuelle Renard et al.

Journal of Biological Chemistry, 2007, 282 (44), pp.32000-32014. ⟨10.1074/jbc.M705197200⟩

Article dans une revue hal-03838477v1

Role of Endogenous Fas (CD95/Apo-1) Ligand in Balloon-Induced Apoptosis, Inflammation, and Neointima Formation

Christian Matter , Christos Chadjichristos , Patricia Meier , Tobias von Lukowicz , Christine Lohmann et al.

Circulation, 2006, 113 (15), pp.1879-1887. ⟨10.1161/CIRCULATIONAHA.106.611731⟩

Article dans une revue hal-03838495v1

Connexin37 protects against atherosclerosis by regulating monocyte adhesion

Cindy Wong , Thomas Christen , Isabelle Roth , Christos Chadjichristos , Jean-Paul Derouette et al.

Nature Medicine, 2006, 12 (8), pp.950-954. ⟨10.1038/nm1441⟩

Article dans une revue hal-03838480v1

Reduced Connexin43 Expression Limits Neointima Formation After Balloon Distension Injury in Hypercholesterolemic Mice

Christos Chadjichristos , Christian Matter , Isabelle Roth , Esther Sutter , Graziano Pelli et al.

Circulation, 2006, 113 (24), pp.2835-2843. ⟨10.1161/CIRCULATIONAHA.106.627703⟩

Article dans une revue hal-03838485v1

A silanized hydroxypropyl methylcellulose hydrogel for the three-dimensional culture of chondrocytes

C. Vinatier , D. Magne , P. Weiss , C. Trojani , N. Rochet et al.

Biomaterials, 2005, 26 (33), pp.6643-6651. ⟨10.1016/j.biomaterials.2005.04.057⟩

Article dans une revue istex hal-03838502v1

Interleukin-1 plays a major role in vascular inflammation and atherosclerosis in male apolipoprotein E-knockout mice

F Merhisoussi , B Kwak , D Magne , Christos Chadjichristos , M Berti et al.

Cardiovascular Research, 2005, 66 (3), pp.583-593. ⟨10.1016/j.cardiores.2005.01.008⟩

Article dans une revue hal-03838505v1

c-Krox down-regulates the expression of UDP–glucose dehydrogenase in chondrocytes

Gallic Beauchef , Magdalini Kypriotou , Christos Chadjichristos , Russell Widom , Benoît Porée et al.

Biochemical and Biophysical Research Communications, 2005, 333 (4), pp.1123-1131. ⟨10.1016/j.bbrc.2005.06.020⟩

Article dans une revue istex hal-03838499v1

A silanized hydroxypropyl methylcellulose hydrogel for the three-dimensional culture of chondrocytes.

Claire Vinatier , David Magne , Pierre Weiss , Christophe Trojani , Nathalie Rochet et al.

Biomaterials, 2005, 26 (33), pp.6643-51. ⟨10.1016/j.biomaterials.2005.04.057⟩

Article dans une revue istex inserm-00110465v1

SOX9 Exerts a Bifunctional Effect on Type II Collagen Gene (COL2A1) Expression in Chondrocytes Depending on the Differentiation State

Magdalini Kypriotou , Magali Fossard-Demoor , Christos Chadjichristos , Chafik Ghayor , Benoit de Crombrugghe et al.

DNA and Cell Biology, 2003, 22 (2), pp.119-129. ⟨10.1089/104454903321515922⟩

Article dans une revue hal-03838513v1

Sp1 and Sp3 Transcription Factors Mediate Interleukin-1β Down-regulation of Human Type II Collagen Gene Expression in Articular Chondrocytes

Christos Chadjichristos , Chafik Ghayor , Magdalini Kypriotou , Grégoire Martin , Renard Emmanuelle et al.

Journal of Biological Chemistry, 2003, 278 (41), pp.39762-39772. ⟨10.1074/jbc.M303541200⟩

Article dans une revue hal-03838509v1

Down-regulation of Human Type II Collagen Gene Expression by Transforming Growth Factor-β1 (TGF-β1) in Articular Chondrocytes Involves SP3/SP1 Ratio

Christos Chadjichristos , Chafik Ghayor , Jean-François Herrouin , Leena Ala-Kokko , Gunthram Suske et al.

Journal of Biological Chemistry, 2002, 277 (46), pp.43903-43917. ⟨10.1074/jbc.M206111200⟩

Article dans une revue hal-03838515v1

SP3 Represses the SP1-mediated Transactivation of the HumanCOL2A1 Gene in Primary and De-differentiated Chondrocytes

Chafik Ghayor , Christos Chadjichristos , Jean-François Herrouin , Leena Ala-Kokko , Guntram Suske et al.

Journal of Biological Chemistry, 2001, 276 (40), pp.36881-36895. ⟨10.1074/jbc.M105083200⟩

Article dans une revue hal-03838523v1

Connexins in Atherosclerosis

Christos Chadjichristos , Jean-Paul Derouette , Brenda Kwak

Cardiovascular Gap Junctions, 42, KARGER, pp.255-267, 2006, ⟨10.1159/000092574⟩

Chapitre d'ouvrage hal-03838488v1

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