Cosette GRANDVALET

Cosette Grandvalet Maître de Conférences (HDR) en Microbiologie Institut Agro Dijon
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Présentation

My research activity focuses on how microorganisms adapt to their environment. With a background in biochemistry and microbiology, I am particularly interested in the molecular mechanisms involved in the microbial response and adaptation to environmental stress. My work is mainly dedicated to the lactic acid bacterium* Oenococcus oeni*, which plays a key role in the malolactic fermentation of wine. Through an adaptative experimental evolution approach, I try to understand the molecular mechanisms that allow this bacterium to maintain its functionality under the challenging conditions of the winemaking environment.

Domaines de recherche

Biotechnologies

Compétences

Génétique microbienne Fermentation malolactique Bactéries lactiques

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Publications

Field Investigation of Flavored Kombucha’s Shelf Life Unveils High Sensitivity of Microbial Dynamics Towards Assimilable Nitrogen

Thierry Tran , Damien Steyer , Francois Verdier , Antoine Martin , Hervé Alexandre et al.
Food and Bioprocess Technology, 2025, 18 (1), pp.370-391. ⟨10.1007/s11947-024-03470-5⟩
Article dans une revue hal-04616122 v1

Influence of pH on Oenococcus oeni metabolism: Can the slowdown of citrate consumption improve its acid tolerance?

Camille Eicher , Thierry Tran , Edouard Munier , Joana Coulon , Marion Favier et al.
Food Research International, 2024, 179, pp.114027. ⟨10.1016/j.foodres.2024.114027⟩
Article dans une revue hal-04434926 v1

Exploring the role of production and release of proteins for microbial interactions in kombucha

Jacqueline Rodriguez Rey , Thierry Tran , Amaury Aumeunier , Aurélie Rieu , François Verdier et al.
LWT - Food Science and Technology, 2024, 198, pp.116016. ⟨10.1016/j.lwt.2024.116016⟩
Article dans une revue hal-04594587 v1
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Citrate metabolism in lactic acid bacteria : is there a beneficial effect for Oenococcus oeni in wine?

Camille Eicher , Joana Coulon , Marion Favier , Hervé Alexandre , Cristina Reguant et al.
Frontiers in Microbiology, 2024, 14, pp.1-13. ⟨10.3389/fmicb.2023.1283220⟩
Article dans une revue hal-04434889 v1
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Identification of Key Parameters Inducing Microbial Modulation during Backslopped Kombucha Fermentation

Claire Daval , Thierry Tran , François Verdier , Antoine Martin , Hervé Alexandre et al.
Foods, 2024, 13 (8), pp.1181. ⟨10.3390/foods13081181⟩
Article dans une revue hal-04594546 v1
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Experimental evolution forcing Oenococcus oeni acid tolerance highlights critical role of the citrate locus

Frédérique Julliat , Camille Eicher , Nezha Tourti , Philippe Glaser , Nicolas Cabanel et al.
Research in Microbiology, 2023, 174 (5), pp.104048. ⟨10.1016/j.resmic.2023.104048⟩
Article dans une revue hal-04034609 v1
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Use of a Minimal Microbial Consortium to Determine the Origin of Kombucha Flavor

Thierry Tran , Kevin Billet , Berta Torres-Cobos , Stefania Vichi , François Verdier et al.
Frontiers in Microbiology, 2022, 13, pp.836617. ⟨10.3389/fmicb.2022.836617⟩
Article dans une revue hal-03648444 v1
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eGFP Gene Integration in HO: A Metabolomic Impact ?

Fanny Bordet , Rémy Romanet , Camille Eicher , Cosette Grandvalet , Géraldine Klein et al.
Microorganisms, 2022, 10 (4), pp.781. ⟨10.3390/microorganisms10040781⟩
Article dans une revue hal-03648411 v1
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Non-Targeted Metabolomic Analysis of the Kombucha Production Process

Thierry Tran , Rémy Romanet , Chloé Roullier-Gall , François Verdier , Antoine Martin et al.
Metabolites, 2022, 12 (2), pp.160. ⟨10.3390/metabo12020160⟩
Article dans une revue hal-03578647 v1
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Evolution in Composition of Kombucha Consortia over Three Consecutive Years in Production Context

Perrine Mas , Thierry Tran , François Verdier , Antoine Martin , Hervé Alexandre et al.
Foods, 2022, 11 (4), pp.614. ⟨10.3390/foods11040614⟩
Article dans une revue hal-03648462 v1
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Oxygen management during kombucha production: Roles of the matrix, microbial activity, and process parameters

Thierry Tran , François Verdier , Antoine Martin , Hervé Alexandre , Cosette Grandvalet et al.
Food Microbiology, 2022, 105, pp.104024. ⟨10.1016/j.fm.2022.104024⟩
Article dans une revue hal-03648386 v1
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Microbial Interactions in Kombucha through the Lens of Metabolomics

Thierry Tran , Chloé Roullier-Gall , François Verdier , Antoine Martin , Philippe Schmitt-Kopplin et al.
Metabolites, 2022, 12 (3), pp.235. ⟨10.3390/metabo12030235⟩
Article dans une revue hal-03641242 v1

Shedding Light on the Formation and Structure of Kombucha Biofilm Using Two-Photon Fluorescence Microscopy

Thierry Tran , Cosette Grandvalet , Pascale Winckler , François Verdier , Antoine Martin et al.
Frontiers in Microbiology, 2021, 12, pp.725379. ⟨10.3389/fmicb.2021.725379⟩
Article dans une revue hal-03338898 v1
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Management of Listeria monocytogenes on Surfaces via Relative Air Humidity: Key Role of Cell Envelope

Fiona Zoz , Stéphane Guyot , Cosette Grandvalet , Mélanie Ragon , Eric Lesniewska et al.
Foods, 2021, 10 (9), pp.1-15. ⟨10.3390/foods10092002⟩
Article dans une revue hal-03327279 v1

Microbiological and technological parameters impacting the chemical composition and sensory quality of kombucha

Thierry Tran , Cosette Grandvalet , François Verdier , Antoine Martin , Herve Alexandre et al.
Comprehensive Reviews in Food Science and Food Safety, 2020, 19 (4), pp.2050-2070. ⟨10.1111/1541-4337.12574⟩
Article dans une revue hal-02874689 v1

Microbial Dynamics between Yeasts and Acetic Acid Bacteria in Kombucha: Impacts on the Chemical Composition of the Beverage

Thierry Tran , Cosette Grandvalet , François Verdier , Antoine Martin , Hervé Alexandre et al.
Foods, 2020, 9 (7), pp.963. ⟨10.3390/foods9070963⟩
Article dans une revue hal-02921242 v1
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CtsR, the Master Regulator of Stress-Response in Oenococcus oeni, Is a Heat Sensor Interacting With ClpL1

Maud Darsonval , Frédérique Julliat , Tarek Msadek , Hervé Alexandre , Cosette Grandvalet
Frontiers in Microbiology, 2018, 9, pp.1-14. ⟨10.3389/fmicb.2018.03135⟩
Article dans une revue hal-01986589 v1

Oenococcus oeni: Queen of the cellar, nightmare of geneticists

Cosette Grandvalet
Microbiology, 2017, 163 (3), pp.297 - 299. ⟨10.1099/mic.0.000456⟩
Article dans une revue hal-01533323 v1

Listeria monocytogenes ability to survive desiccation: Influence of serotype, origin, virulence, and genotype

Fiona Zoz , Cosette Grandvalet , Emilie Lang , Cyril Laconelli , Patrick Gervais et al.
International Journal of Food Microbiology, 2017, 248, pp.82 - 89. ⟨10.1016/j.ijfoodmicro.2017.02.010⟩
Article dans une revue hal-01509875 v1

Genetically engineered Oenococcus oeni strains to highlight the impact of estA2 and estA7 esterase genes on wine ester profile

Maud Darsonval , Hervé Alexandre , Cosette Grandvalet
Food Microbiology, 2016, 60, pp.21 - 28. ⟨10.1016/j.fm.2016.06.012⟩
Article dans une revue hal-01446229 v1
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The antisense RNA approach: a new application for in vivo investigation of the stress response of Oenococcus oeni, a wine-associated lactic acid bacterium

Maud Darsonval , Tarek Msadek , Hervé Alexandre , Cosette Grandvalet
Applied and Environmental Microbiology, 2016, 82 (1), pp.18-26. ⟨10.1128/AEM.02495-15⟩
Article dans une revue hal-01446281 v1

Control of Relative Air Humidity as a Potential Means to Improve Hygiene on Surfaces: A Preliminary Approach with Listeria monocytogenes

Fiona Zoz , Cyril Laconelli , Émilie Lang , Stéphane Guyot , Cosette Grandvalet et al.
PLoS ONE, 2016, 11 (2), ⟨10.1371/journal.pone.0148418⟩
Article dans une revue hal-01466198 v1

Cyclopropane Fatty Acid Synthase from Oenococcus oeni: Expression in Lactococcus lactis subsp. Cremoris and Biochemical Characterization

Thi Mai Huong To , Cosette Grandvalet , Hervé Alexandre , Raphaëlle Tourdot-Maréchal
Archives of Microbiology, 2015
Article dans une revue hal-01326090 v1

Tyrosine-containing peptides are precursors of tyramine produced by Lactobacillus plantarum strain IR BL0076 isolated from wine

Maryse Bonnin-Jusserand , Cosette Grandvalet , Aurélie Rieu , Stéphanie Weidmann , Hervé Alexandre
BMC Microbiology, 2012, 12 (1), pp.199. ⟨10.1186/1471-2180-12-199⟩
Article dans une revue hal-03140066 v1

Molecular Cloning, Heterologous Expression, and Characterization of Ornithine Decarboxylase from Oenococcus oeni

Maryse Bonnin-Jusserand , Cosette Grandvalet , Vanessa David , Hervé Alexandre
Journal of Food Protection, 2011, 74 (8), pp.1309-1314. ⟨10.4315/0362-028X.JFP-10-466⟩
Article dans une revue hal-03140059 v1

Cyclopropanation of Membrane Unsaturated Fatty Acids Is Not Essential to the Acid Stress Response of Lactococcus lactis subsp. cremoris

Thi Mai Huong To , Cosette Grandvalet , Hervé H. Alexandre , Raphaëlle Tourdot-Maréchal
Applied and Environmental Microbiology, 2011, 77 (10)
Article dans une revue hal-01326108 v1

Biogenic amines in fermented foods

G. Spano , P. Russo , Aline Lonvaud-Funel , Patrick Lucas , H. Alexandre et al.
European Journal of Clinical Nutrition, 2010, 64, pp.S95-S100. ⟨10.1038/ejcn.2010.218⟩
Article dans une revue hal-02666992 v1

Peptidases specific for proline-containing peptides and their unusual peptide-dependent regulation in Oenococcus oeni

Jean-Francois Ritt , Fabienne Remize , Cosette Grandvalet , Jean Guzzo , Danièle Atlan et al.
Journal of Applied Microbiology, 2009, 106 (3), pp.801--813. ⟨10.1111/j.1365-2672.2008.04032.x⟩
Article dans une revue hal-01201608 v1

An improved protocol for electroporation of Oenococcus oeni ATCC BAA-1163 using ethanol as immediate membrane fluidizing agent

Juan-Simon Assad-Garcia , Maryse Bonnin-Jusserand , Dominique D. Garmyn , Jean Guzzo , Hervé Alexandre et al.
Letters in Applied Microbiology, 2008, 47 (4), pp.333 - 338. ⟨10.1111/j.1472-765X.2008.02435.x⟩
Article dans une revue hal-02663266 v1

Changes in membrane lipid composition in ethanol- and acid-adapted Oenococcus oeni cells: characterization of the cfa gene by heterologous complementation

Cosette Grandvalet , Juan Simón Assad-García , Son Chu-Ky , Marie Tollot , Jean Guzzo et al.
Microbiology, 2008, 154 (9), pp.2611-2619. ⟨10.1099/mic.0.2007/016238-0⟩
Article dans une revue hal-03140144 v1

Real-time PCR for characterizing the stress response of Oenococcus oeni in a wine-like medium

Charlotte Beltramo , Nicolas Desroche , Raphaëlle Tourdot-Maréchal , Cosette Grandvalet , Jean Guzzo
Research in Microbiology, 2006, 157 (3), pp.267-274. ⟨10.1016/j.resmic.2005.07.006⟩
Article dans une revue istex hal-03140049 v1

CtsR Is the Master Regulator of Stress Response Gene Expression in Oenococcus oeni

Cosette Grandvalet , Françoise Coucheney , Charlotte Beltramo , Jean Guzzo
Journal of Bacteriology, 2005, 187 (16), pp.5614-5623. ⟨10.1128/JB.187.16.5614-5623.2005⟩
Article dans une revue hal-03140158 v1

Evidence for multiple levels of regulation of Oenococcus oeni clpP-clpL locus expression in response to stress.

Charlotte Beltramo , Cosette Grandvalet , Fabrice H.F. Pierre , Jean Guzzo
Journal of Bacteriology, 2004, 186 (7), pp.2200-5. ⟨10.1128/JB.186.7.2200–2205.2003⟩
Article dans une revue hal-02670232 v1
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Expression différentielle des deux gènes du locus clpP-clpL de Oenococcus oeni

Charlotte Beltramo , Cosette Grandvalet , Jean Guzzo
Le Lait, 2004, 84 (1-2), pp.87-93. ⟨10.1051/lait:2003035⟩
Article dans une revue hal-00895520 v1

Identification of genes involved in the activation of the Bacillus thuringiensis inhA metalloprotease gene at the onset of sporulation

Cosette Grandvalet , M. Gominet , Didier D. Lereclus
Microbiology, 2001, 147 (7), pp.1805-1813
Article dans une revue hal-02679315 v1

Regulation of toxin and virulence gene transcription in Bacillus thuringiensis

Didier D. Lereclus , Hervé Agaisse , Cosette Grandvalet , S. Salamitou , M. Gominet
International Journal of Medical Microbiology, 2000, 290 (4-5), pp.295-299
Article dans une revue hal-02696391 v1

The RheA repressor is the thermosensor of the HSP18 heat shock response in Streptomyces albus

Pascale Servant , Cosette Grandvalet , Philippe Mazodier
Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 (7), pp.3538-3543. ⟨10.1073/pnas.97.7.3538⟩
Article dans une revue hal-03140180 v1

Alteration of the synthesis of the Clp ATP-dependent protease affects morphological and physiological differentiation in Streptomyces

Valerie de Crecy-Lagard , Pascale Servant-Moisson , Julie Viala , Cosette Grandvalet , Philippe Mazodier
Molecular Microbiology, 1999, 32 (3), pp.505-517. ⟨10.1046/j.1365-2958.1999.01364.x⟩
Article dans une revue hal-03140074 v1

The ClpB ATPase of Streptomyces albus G belongs to the HspR heat shock regulon

Cosette Grandvalet , Valerie de Crecy-Lagard , Philippe Mazodier
Molecular Microbiology, 1999, 31 (2), pp.521-532. ⟨10.1046/j.1365-2958.1999.01193.x⟩
Article dans une revue hal-03140079 v1

hrcA, Encoding the Repressor of the groELGenes in Streptomyces albus G, Is Associated with a SeconddnaJ Gene

Cosette Grandvalet , Georges Rapoport , Philippe Mazodier
Journal of Bacteriology, 1998, 180 (19), pp.5129-5134. ⟨10.1128/JB.180.19.5129-5134.1998⟩
Article dans une revue hal-03140129 v1

Disruption of hspR , the repressor gene of the dnaK operon in Streptomyces albus G

Cosette Grandvalet , Pascale Servant , Philippe Mazodier
Molecular Microbiology, 1997, 23 (1), pp.77-84. ⟨10.1046/j.1365-2958.1997.1811563.x⟩
Article dans une revue hal-03140133 v1
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Metabolomics to decode microbial interactions in kombucha beverage

Thierry Tran , Chloé Roullier-Gall , Francois Verdier , Antoine Martin , Philippe Schmitt-Kopplin et al.
10th FEMS Congress of European Microbiologists, Jul 2023, Hambourg, Germany. , 2023
Poster de conférence hal-04209781 v1

Control of Listeria monocytogenes present on surfaces by managing the Relative Humidity of the air. International Congress on Engineering and Food

Stéphane Guyot , Fiona Zoz , Cosette Grandvalet , Sébastien Dupont , Mélanie Ragon et al.
International Congress on Engineering and Food (ICEF14), 2023, Nantes, France
Poster de conférence hal-05251566 v1
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Polyphenols in kombucha: impact of infusion time on extraction and investigation of their behavior during "fermentation

Thierry Tran , Cosette Grandvalet , François Verdier , Antoine Martin , Herve Alexandre et al.
Wine Active Compounds 2022, Jun 2022, Dijon, France.
Poster de conférence hal-03773246 v1
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Directed evolution of oenococcus oeni to improve acid-tolerance reveals fixed beneficial mutations in the citrate locus

Camille Eicher , Frédérique Julliat , Joana Coulon , Marion Favier , Herve Alexandre et al.
27th International ICFMH Conférence FoodMicro, Jul 2022, Athènes, Greece.
Poster de conférence hal-03773876 v1
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Polyphenols in kombucha: Metabolomic analysis of biotransformations during fermentation

Thierry Tran , Rémy Romanet , Chloé Roullier-Gall , François Verdier , Antoine Martin et al.
5th International Conference on Wine Active Compounds (WAC 2022), Jun 2022, Dijon, France.
Poster de conférence hal-03773257 v1
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Using CRISPR/Cas platform for Genetic Modification of Commercial Saccharomyces cerevisiae strains

C. Eicher , Géraldine L. Klein , Pascale Winckler , Jean-Luc Parrou , Hervé Alexandre et al.
OENO-IVAS 2019, Jun 2019, Bordeaux, France
Poster de conférence hal-02466806 v1
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Adaptive evolution to improve acid tolerance in Oenococcus oeni

Frédérique Julliat , N. Tourti , Stéphane Guyot , Herve Alexandre , Cosette Grandvalet
11th international synposium of oenology of Bordeaux, Jun 2019, Bordeaux, France
Poster de conférence hal-03150729 v1
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Oenococcus oeni : advances in molecular genetics

Cosette Grandvalet , Maud Darsonval , Frédérique Julliat , Herve Alexandre
12th International Symposium on Lactic Acid Bacteria (LAB), Aug 2017, Egmond aan Zee, Netherlands
Poster de conférence hal-03150705 v1
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Improving acid tolerance in Oenococcus oeni by Adaptive Evolution

Frédérique Julliat , Stéphane Guyot , Herve Alexandre , Cosette Grandvalet
12th International Symposium on Lactic Acid Bacteria (LAB), Aug 2017, Egmond aan Zee, Netherlands
Poster de conférence hal-03150712 v1
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Use of antisense RNA to modulate HSP gene expression in oenococcus oeni

Maud Darsonval , Tarek Msadek , Herve Alexandre , Cosette Grandvalet
FEMS 6th congress of european Microbiologists, Jun 2015, Maastricht, Netherlands
Poster de conférence hal-03150745 v1

Les bactéries lactiques en oenologie : Connaissances actuelles

H. Alexandre , Cosette Grandvalet , Michèle Guilloux-Benatier , Fabienne Remize-Barnavon , Raphaëlle Tourdot-Maréchal
Les bactéries lactiques en oenologie : Connaissances actuelles, Lavoisier / Tec & Doc, pp.172, 2008, 978-2-7430-1041-6
Chapitre d'ouvrage hal-05261536 v1