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Conformational diversity in class C GPCR positive allosteric modulation
Giuseppe Cannone
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hal-04889109
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A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs
Serena Notartomaso
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Mariacristina Mazzitelli
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Xavier Rovira
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Article dans une revue
hal-04676043
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Optical Control of Adenosine A 2A Receptor Using Istradefylline Photosensitivity
Anaëlle Dumazer
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Fanny Malhaire
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Chris Jopling
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Damien Maurel
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Article dans une revue
hal-04425630
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Novel Inhibitory Site Revealed by XAP044 Mode of Action on the Metabotropic Glutamate 7 Receptor Venus Flytrap Domain
Nunzia Cristiano
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Isabelle Brabet
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Ralf Glatthar
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Amelie Tora
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Article dans une revue
hal-04569147
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Photoswitchable positive allosteric modulators of metabotropic glutamate receptor 4 to improve selectivity
Silvia Panarello
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Alice E Berizzi
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Fanny Malhaire
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Roser Borràs-Tudurí
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Article dans une revue
hal-04609139
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Photopharmacological manipulation of amygdala metabotropic glutamate receptor mGlu4 alleviates neuropathic pain
Vanessa Pereira
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Amadeu Llebaria
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Article dans une revue
(data paper)
hal-03914258
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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
Stephen Alexander
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Article dans une revue
hal-04858591
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Editorial: Molecular mechanisms of nociception
Cyril Goudet
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Fabien Marchand
Article dans une revue
hal-03805607
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International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors
Karen J Gregory
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Article dans une revue
hal-03099669
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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors
Stephen Alexander
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Arthur Christopoulos
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Anthony Davenport
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Eamonn Kelly
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Alistair Mathie
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Article dans une revue
hal-03875300
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Les avancées récentes dans le domaine de la biologie structurale des récepteurs couplés aux protéines G de la classe C : Le récepteur métabotropique du glutamate 5
Ludovic Berto
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Anaëlle Dumazer
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Fanny Malhaire
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Giuseppe Cannone
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Vinothkumar Kutti
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Article dans une revue
hal-03744975
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Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations
Chady Nasrallah
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Giuseppe Cannone
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Julie Briot
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Karine Rottier
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Alice Berizzi
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Article dans une revue
hal-03340751
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Development and validation of a mass spectrometry binding assay for mGlu5 receptor
Maria Ricart-Ortega
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Alice Berizzi
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Juanlo Catena
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Fanny Malhaire
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Lourdes Muñoz
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Article dans une revue
hal-02884945
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Mechanistic insights into light-driven allosteric control of GPCR biological activity
Maria Ricart-Ortega
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Vanessa Pereira
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Fanny Malhaire
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Juanlo Catena
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Article dans une revue
hal-02924800
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THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors
Stephen Alexander
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Arthur Christopoulos
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Anthony P Davenport
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Eamonn Kelly
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Alistair Mathie
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Article dans une revue
hal-02388696
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Emerging Trends in Pain Modulation by Metabotropic Glutamate Receptors
Vanessa Pereira
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Cyril Goudet
Article dans une revue
hal-02388671
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Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4
Charleine Zussy
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X. Gomez-Santacana
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Xavier Rovira
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Dimitri de Bundel
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S. Ferrazzo
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Article dans une revue
hal-02073218
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Shedding light on metabotropic glutamate receptors using optogenetics and photopharmacology
Cyril Goudet
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Xavier Rovira
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Amadeu Llebaria
Article dans une revue
hal-02388700
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Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites
Chelliah Selvam
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Isabelle Lemasson
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Isabelle Brabet
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Nadia Oueslati
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Berin Karaman
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Article dans une revue
hal-02018007
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Profiling of orthosteric and allosteric group-III metabotropic glutamate receptor ligands on various G protein-coupled receptors with Tag-lite® assays
Abderazak Belhocine
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Pietro Veglianese
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Candide Hounsou
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Elodie Dupuis
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Francine C. Acher
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Article dans une revue
hal-02388698
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Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3
Amélie S. Tora
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Xavier Rovira
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Anne-Marinette Cao
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Alexandre Cabaye
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Linnea Olofsson
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Article dans une revue
hal-02346230
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Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer
Junke Liu
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Zongyong Zhang
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David Moreno-Delgado
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James Ar Dalton
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Xavier Rovira
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Article dans une revue
hal-02073040
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Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu 5 negative allosteric modulation
Xavier Gómez-Santacana
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James Dalton
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Xavier Rovira
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Jean-Philippe Pin
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Cyril Goudet
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Article dans une revue
hal-02066019
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Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals
Xavier Gómez-Santacana
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Silvia Pittolo
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Xavier Rovira
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Marc Lopez
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Charleine Zussy
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Article dans une revue
hal-02066097
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Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator
Joan Font
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Marc López-Cano
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Serena Notartomaso
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Pamela Scarselli
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Paola Di Pietro
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Article dans une revue
hal-03549950
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OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity
Xavier Rovira
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Ana Trapero
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Silvia Pittolo
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Charleine Zussy
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Adèle Faucherre
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Article dans une revue
hal-01941168
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New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III
Tri H. V. Huynh
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Mette N. Erichsen
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Amélie S. Tora
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Cyril Goudet
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Emmanuelle Sagot
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Article dans une revue
hal-01288609
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Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective
James Dalton
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Isaias Lans
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Xavier Rovira
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Fanny Malhaire
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Xavier Gómez-Santacana
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Article dans une revue
hal-02448289
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Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors
Xavier Rovira
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Fanny Malhaire
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Pauline Scholler
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Jordi Rodrigo
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P. Gonzalez-Bulnes
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Article dans une revue
hal-01943324
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Determination of the absolute configuration of phosphinic analogues of glutamate
Bruno Commare
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Delphine Rigault
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Isabelle Lemasson
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Patrick Deschamps
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Alain Tomas
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Article dans une revue
hal-02268872
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Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers
Pavel Ivashkin
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Gérald Lemonnier
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Amélie S. Tora
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Jean-Philippe Pin
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Cyril Goudet
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Article dans une revue
hal-01180138
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Allosteric modulation of metabotropic glutamate receptors by chloride ions
Amélie S. Tora
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Xavier Rovira
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Ibrahima Dione
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Hugues-Olivier Bertrand
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Isabelle Brabet
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Article dans une revue
hal-02065116
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Therapeutic potential of group III metabotropic glutamate receptor ligands in pain
Francine Acher
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Cyril Goudet
Article dans une revue
hal-01950127
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Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor
Xavier Rovira
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Youssef Harrak
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Ana Trapero
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Patricia Gonzalez-Bulnes
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Fanny Malhaire
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Article dans une revue
istex
hal-01943327
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An allosteric modulator to control endogenous G protein-coupled receptors with light
S. Pittolo
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X. Gomez-Santacana
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K. Eckelt
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Xavier Rovira
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J. Dalton
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Article dans une revue
hal-01942934
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Alleviating Pain Hypersensitivity through Activation of Type 4 Metabotropic Glutamate Receptor
Bruno Vilar
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Jérôme Busserolles
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Bing Ling
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Sophie Laffray
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Lauriane Ulmann
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Article dans une revue
hal-02448295
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Α-amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4.
Gérald Lemonnier
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Cédric Lion
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Jean-Charles Quirion
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Jean-Philippe Pin
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Cyril Goudet
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Article dans une revue
istex
hal-00996602
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Cinnabarinic Acid, an Endogenous Metabolite of the Kynurenine Pathway, Activates Type 4 Metabotropic Glutamate Receptors
F. Fazio
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L. Lionetto
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G. Molinaro
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H. Bertrand
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F. Acher
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Article dans une revue
hal-02448364
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A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential.
Cyril Goudet
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Bruno Vilar
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Tiphanie Courtiol
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Thierry Deltheil
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Thomas Bessiron
et al.
Article dans une revue
hal-01182946
v1
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A new Selective Metabotropic Glutamate Receptor type 4 Agonist Reveals New ways to Develop Subtype Selective Orthosteric Ligands with Potential Therapeutic Effects
Cyril Goudet
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Bruno Vilar
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Tiphanie Courtiol
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Thierry Deltheil
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Thomas Bessiron
et al.
Current Neuropharmacology, 2011, 9 (1), pp.26
Article dans une revue
hal-01384798
v1
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Is metabotropic glutamate receptor mGlu4R a good target to treat Parkinson's disease symptoms? Design and evaluation of potent and selective agonists
Isabelle A. Lemasson
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Chelliah Selvam
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Nadia Oueslati
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Isabelle Brabet
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Tiphanie Courtiol
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Abstracts of Papers of the American Chemical Society, 2009, 238
Article dans une revue
hal-01384832
v1
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LSP1-2111, a new orthosteric group III mGlur agonist with preferential activity on mGluR4, modulates the striatopallidal synapse and alleviates parkinsonian symptoms
C. Beurrier
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D. Revy
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S. Lopez
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M. Lherondel
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Cyril Goudet
et al.
Article dans une revue
istex
hal-01384860
v1
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N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.
Yelin Chen
,
Cyril Goudet
,
Jean-Philippe Pin
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P Jeffrey Conn
Article dans une revue
inserm-00318958
v1
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Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.
Yelin Chen
,
Yi Nong
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Cyril Goudet
,
Kamondanai Hemstapat
,
Tomas de Paulis
et al.
Article dans une revue
inserm-00319012
v1
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Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.
Pauline Sibille
,
Sébastien Lopez
,
Isabelle Brabet
,
Ornella Valenti
,
Nadia Oueslati
et al.
Article dans une revue
istex
inserm-00318976
v1
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Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain
Cyril Goudet
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Eric Chapuy
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Abdelkrim Alloui
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Francine Acher
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Jean-Philippe Pin
et al.
Article dans une revue
inserm-00318859
v1
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L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.
Chelliah Selvam
,
Cyril Goudet
,
Nadia Oueslati
,
Jean-Philippe Pin
,
Francine C. Acher
Article dans une revue
istex
inserm-00318965
v1
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D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation.
Eric Trinquet
,
Michel Fink
,
Hervé Bazin
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Florence Grillet
,
Fabrice Maurin
et al.
Article dans une revue
istex
inserm-00318996
v1
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Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR.
Veronika Hlavackova
,
Cyril Goudet
,
Julie Kniazeff
,
Alice Zikova
,
Damien Maurel
et al.
Article dans une revue
inserm-00318934
v1
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Allosteric functioning of dimeric class C G-protein-coupled receptors.
Jean-Philippe Pin
,
Julie Kniazeff
,
Jianfeng Liu
,
Virginie Binet
,
Cyril Goudet
et al.
Article dans une revue
inserm-00094959
v1
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Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators.
Cyril Goudet
,
Julie Kniazeff
,
Veronika Hlavackova
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Fanny Malhaire
,
Damien Maurel
et al.
Article dans une revue
inserm-00318925
v1
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Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.
Cyril Goudet
,
Florence Gaven
,
Julie Kniazeff
,
Claire Vol
,
Jianfeng Liu
et al.
Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (1), pp.378-83. ⟨10.1073/pnas.0304699101⟩
Article dans une revue
inserm-00319003
v1
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Locking the dimeric GABA(B) G-protein-coupled receptor in its active state.
Julie Kniazeff
,
Pierre-Philippe Saintot
,
Cyril Goudet
,
Jianfeng Liu
,
Annie Charnet
et al.
Article dans une revue
hal-00319013
v1
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Magnesium ions promote assembly of channel-like structures from beticolin o, a non-peptide fungal toxin purified from Cercospora beticola
Cyril Goudet
,
Anne-Aliénor Véry
,
M.L. Milat
,
M. Ildefonse
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Jean-Baptiste Thibaud
et al.
Article dans une revue
hal-02690441
v1
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