Cyril Goudet

61
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Publications

Publications

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Conformational diversity in class C GPCR positive allosteric modulation

Giuseppe Cannone , Ludovic Berto , Fanny Malhaire , Gavin Ferguson , Aurelien Fouillen et al.

Nature Communications, 2025, 16 (1), pp.619. ⟨10.1038/s41467-024-55439-9⟩

Article dans une revue hal-04889109v1
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Bistable and Water‐Operable Hemiindigo Photoswitches Allow Optical Control of Acetylcholinesterase Activity with Visible Light

Letícia da Mata Lazinski , Morane Beaumet , Frédérique Loiseau , Cyril Goudet , Martial Boggio‐pasqua et al.

ChemistryEurope, 2025, 3 (5), pp.e202500221. ⟨10.1002/ceur.202500221⟩

Article dans une revue hal-05339073v1
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A photoswitchable positive allosteric modulator to control the activation of the metabotropic glutamate receptor 5 by light

Anaëlle Dumazer , Roser Borras-Tuduri , Iona Truong , Xiaojing Cong , Fanny Malhaire et al.

Biochemical Pharmacology, 2025, 240, pp.117065. ⟨10.1016/j.bcp.2025.117065⟩

Article dans une revue hal-05140566v1
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A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs

Serena Notartomaso , Nico Antenucci , Mariacristina Mazzitelli , Xavier Rovira , Serena Boccella et al.

eLife, 2024, 13, pp.e94931. ⟨10.7554/eLife.94931⟩

Article dans une revue hal-04676043v1
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Optical Control of Adenosine A 2A Receptor Using Istradefylline Photosensitivity

Anaëlle Dumazer , Xavier Gómez-Santacana , Fanny Malhaire , Chris Jopling , Damien Maurel et al.

ACS Chemical Neuroscience, In press, 15 (3), pp.645-655. ⟨10.1021/acschemneuro.3c00721⟩

Article dans une revue hal-04425630v1
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Photoswitchable positive allosteric modulators of metabotropic glutamate receptor 4 to improve selectivity

Silvia Panarello , Aleix González-Díez , Alice E Berizzi , Fanny Malhaire , Roser Borràs-Tudurí et al.

iScience, 2024, 27 (6), pp.110123. ⟨10.1016/j.isci.2024.110123⟩

Article dans une revue hal-04609139v1
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Novel Inhibitory Site Revealed by XAP044 Mode of Action on the Metabotropic Glutamate 7 Receptor Venus Flytrap Domain

Nunzia Cristiano , Alexandre Cabayé , Isabelle Brabet , Ralf Glatthar , Amelie Tora et al.

Journal of Medicinal Chemistry, In press, 67 (14), pp.11662-11687. ⟨10.1021/acs.jmedchem.3c01924⟩

Article dans une revue hal-04569147v1
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Photopharmacological manipulation of amygdala metabotropic glutamate receptor mGlu4 alleviates neuropathic pain

Vanessa Pereira , Juri Aparicio Arias , Amadeu Llebaria , Cyril Goudet

Pharmacological Research, 2023, 187, pp.106602. ⟨10.1016/j.phrs.2022.106602⟩

Article dans une revue (data paper) hal-03914258v1

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

Stephen Alexander , Arthur Christopoulos , Anthony Davenport , Eamonn Kelly , Alistair Mathie et al.

British Journal of Pharmacology, 2023, 180 (S2), pp.S23-S144. ⟨10.1111/bph.16177⟩

Article dans une revue hal-04858591v1
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Editorial: Molecular mechanisms of nociception

Cyril Goudet , Fabien Marchand

Frontiers in Molecular Neuroscience, 2022, 15, pp.1025230. ⟨10.3389/fnmol.2022.1025230⟩

Article dans une revue hal-03805607v1
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International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors

Karen J Gregory , Cyril Goudet

Pharmacological Reviews, 2021, 73 (1), pp.521-569. ⟨10.1124/pr.119.019133⟩

Article dans une revue hal-03099669v1
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Les avancées récentes dans le domaine de la biologie structurale des récepteurs couplés aux protéines G de la classe C : Le récepteur métabotropique du glutamate 5

Ludovic Berto , Anaëlle Dumazer , Fanny Malhaire , Giuseppe Cannone , Vinothkumar Kutti et al.

Biologie Aujourd'hui, 2021, 215 (3-4), pp.85-94. ⟨10.1051/jbio/2021013⟩

Article dans une revue hal-03744975v2

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

Stephen Alexander , Arthur Christopoulos , Anthony Davenport , Eamonn Kelly , Alistair Mathie et al.

British Journal of Pharmacology, 2021, 178 (S1), pp.e0243333. ⟨10.1111/bph.15538⟩

Article dans une revue hal-03875300v1
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Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations

Chady Nasrallah , Giuseppe Cannone , Julie Briot , Karine Rottier , Alice Berizzi et al.

Cell Reports, 2021, 36 (9), pp.109648. ⟨10.1016/j.celrep.2021.109648⟩

Article dans une revue hal-03340751v1
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Development and validation of a mass spectrometry binding assay for mGlu5 receptor

Maria Ricart-Ortega , Alice Berizzi , Juanlo Catena , Fanny Malhaire , Lourdes Muñoz et al.

Analytical and Bioanalytical Chemistry, In press, 412 (22), pp.5525-5535. ⟨10.1007/s00216-020-02772-9⟩

Article dans une revue hal-02884945v1
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Mechanistic insights into light-driven allosteric control of GPCR biological activity

Maria Ricart-Ortega , Alice Berizzi , Vanessa Pereira , Fanny Malhaire , Juanlo Catena et al.

ACS Pharmacology & Translational Science, 2020, 3 (5), pp.883-895. ⟨10.1021/acsptsci.0c00054⟩

Article dans une revue hal-02924800v1
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THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

Stephen Alexander , Arthur Christopoulos , Anthony P Davenport , Eamonn Kelly , Alistair Mathie et al.

British Journal of Pharmacology, 2019, 176 (S1), pp.S21-S141. ⟨10.1111/bph.14748⟩

Article dans une revue hal-02388696v1
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Emerging Trends in Pain Modulation by Metabotropic Glutamate Receptors

Vanessa Pereira , Cyril Goudet

Frontiers in Molecular Neuroscience, 2019, 11, pp.464. ⟨10.3389/fnmol.2018.00464⟩

Article dans une revue hal-02388671v1
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Shedding light on metabotropic glutamate receptors using optogenetics and photopharmacology

Cyril Goudet , Xavier Rovira , Amadeu Llebaria

Current Opinion in Pharmacology, 2018, 38, pp.8-15. ⟨10.1016/j.coph.2018.01.007⟩

Article dans une revue hal-02388700v1

Profiling of orthosteric and allosteric group-III metabotropic glutamate receptor ligands on various G protein-coupled receptors with Tag-lite® assays

Abderazak Belhocine , Pietro Veglianese , Candide Hounsou , Elodie Dupuis , Francine C. Acher et al.

Neuropharmacology, 2018, 140, pp.233-245. ⟨10.1016/j.neuropharm.2018.07.032⟩

Article dans une revue istex hal-02388698v1

Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites

Chelliah Selvam , Isabelle Lemasson , Isabelle Brabet , Nadia Oueslati , Berin Karaman et al.

Journal of Medicinal Chemistry, 2018, 61 (5), pp.1969-1989. ⟨10.1021/acs.jmedchem.7b01438⟩

Article dans une revue hal-02018007v1
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Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4

Charleine Zussy , X. Gomez-Santacana , Xavier Rovira , Dimitri de Bundel , S. Ferrazzo et al.

Molecular Psychiatry, 2018, 23 (3), pp.509-520. ⟨10.1038/mp.2016.223⟩

Article dans une revue hal-02073218v1
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Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3

Amélie S. Tora , Xavier Rovira , Anne-Marinette Cao , Alexandre Cabaye , Linnea Olofsson et al.

Neuropharmacology, 2018, 140, pp.275-286. ⟨10.1016/j.neuropharm.2018.08.011⟩

Article dans une revue hal-02346230v1
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Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer

Junke Liu , Zongyong Zhang , David Moreno-Delgado , James Ar Dalton , Xavier Rovira et al.

eLife, 2017, 6, ⟨10.7554/eLife.26985⟩

Article dans une revue hal-02073040v1

Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu 5 negative allosteric modulation

Xavier Gómez-Santacana , James Dalton , Xavier Rovira , Jean-Philippe Pin , Cyril Goudet et al.

European Journal of Medicinal Chemistry, 2017, 127, pp.567-576. ⟨10.1016/j.ejmech.2017.01.013⟩

Article dans une revue hal-02066019v1
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Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals

Xavier Gómez-Santacana , Silvia Pittolo , Xavier Rovira , Marc Lopez , Charleine Zussy et al.

ACS Central Science, 2017, 3 (1), pp.81-91. ⟨10.1021/acscentsci.6b00353⟩

Article dans une revue hal-02066097v1
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Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

Joan Font , Marc López-Cano , Serena Notartomaso , Pamela Scarselli , Paola Di Pietro et al. Article dans une revue hal-03549950v1
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OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity

Xavier Rovira , Ana Trapero , Silvia Pittolo , Charleine Zussy , Adèle Faucherre et al.

Cell Chemical Biology, 2016, 23 (8), pp.929--34. ⟨10.1016/j.chembiol.2016.06.013⟩

Article dans une revue hal-01941168v1

New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III

Tri H. V. Huynh , Mette N. Erichsen , Amélie S. Tora , Cyril Goudet , Emmanuelle Sagot et al.

Journal of Medicinal Chemistry, 2016, 59, pp.914-924. ⟨10.1021/acs.jmedchem.5b01333⟩

Article dans une revue hal-01288609v1

Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective

James Dalton , Isaias Lans , Xavier Rovira , Fanny Malhaire , Xavier Gómez-Santacana et al.

Current Neuropharmacology, 2016, 14 (5), pp.441-454. ⟨10.2174/1570159x13666150407231417⟩

Article dans une revue hal-02448289v1

Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors

Xavier Rovira , Fanny Malhaire , Pauline Scholler , Jordi Rodrigo , P. Gonzalez-Bulnes et al.

FASEB Journal, 2015, 29 (1), pp.116--30. ⟨10.1096/fj.14-257287⟩

Article dans une revue hal-01943324v1

Determination of the absolute configuration of phosphinic analogues of glutamate

Bruno Commare , Delphine Rigault , Isabelle Lemasson , Patrick Deschamps , Alain Tomas et al.

Organic & Biomolecular Chemistry, 2015, 13 (4), pp.1106-1112. ⟨10.1039/C4OB01960A⟩

Article dans une revue hal-02268872v1

Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers

Pavel Ivashkin , Gérald Lemonnier , Amélie S. Tora , Jean-Philippe Pin , Cyril Goudet et al.

Bioorganic and Medicinal Chemistry Letters, 2015, 25 (12), pp.2523-2526. ⟨10.1016/j.bmcl.2015.04.043⟩

Article dans une revue hal-01180138v1

Allosteric modulation of metabotropic glutamate receptors by chloride ions

Amélie S. Tora , Xavier Rovira , Ibrahima Dione , Hugues-Olivier Bertrand , Isabelle Brabet et al.

FASEB Journal, 2015, 29 (10), pp.4174-4188. ⟨10.1096/fj.14-269746⟩

Article dans une revue hal-02065116v1
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Therapeutic potential of group III metabotropic glutamate receptor ligands in pain

Francine Acher , Cyril Goudet

Current Opinion in Pharmacology, 2015, 20, pp.64-72. ⟨10.1016/j.coph.2014.11.007⟩

Article dans une revue hal-01950127v1

Exploring the active conformation of cyclohexane carboxylate positive allosteric modulators of the type 4 metabotropic glutamate receptor

Xavier Rovira , Youssef Harrak , Ana Trapero , Patricia Gonzalez-Bulnes , Fanny Malhaire et al.

ChemMedChem, 2014, 9 (12), pp.2685--98. ⟨10.1002/cmdc.201402190⟩

Article dans une revue istex hal-01943327v1

An allosteric modulator to control endogenous G protein-coupled receptors with light

S. Pittolo , X. Gomez-Santacana , K. Eckelt , Xavier Rovira , J. Dalton et al.

Nature Chemical Biology, 2014, 10 (10), pp.813--5. ⟨10.1038/nchembio.1612⟩

Article dans une revue hal-01942934v1
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Alleviating Pain Hypersensitivity through Activation of Type 4 Metabotropic Glutamate Receptor

Bruno Vilar , Jérôme Busserolles , Bing Ling , Sophie Laffray , Lauriane Ulmann et al.

Journal of Neuroscience, 2013, 33 (48), pp.18951-18965. ⟨10.1523/JNEUROSCI.1221-13.2013⟩

Article dans une revue hal-02448295v1

Α-amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4.

Gérald Lemonnier , Cédric Lion , Jean-Charles Quirion , Jean-Philippe Pin , Cyril Goudet et al.

Bioorganic and Medicinal Chemistry, 2012, 20 (15), pp.4716-26. ⟨10.1016/j.bmc.2012.06.006⟩

Article dans une revue istex hal-00996602v1

Cinnabarinic Acid, an Endogenous Metabolite of the Kynurenine Pathway, Activates Type 4 Metabotropic Glutamate Receptors

F. Fazio , L. Lionetto , G. Molinaro , H. Bertrand , F. Acher et al.

Molecular Pharmacology, 2012, 81 (5), pp.643-656. ⟨10.1124/mol.111.074765⟩

Article dans une revue hal-02448364v1

A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential.

Cyril Goudet , Bruno Vilar , Tiphanie Courtiol , Thierry Deltheil , Thomas Bessiron et al.

FASEB Journal, 2012, 26 (4), pp.1682-93. ⟨10.1096/fj.11-195941⟩

Article dans une revue hal-01182946v1

A new Selective Metabotropic Glutamate Receptor type 4 Agonist Reveals New ways to Develop Subtype Selective Orthosteric Ligands with Potential Therapeutic Effects

Cyril Goudet , Bruno Vilar , Tiphanie Courtiol , Thierry Deltheil , Thomas Bessiron et al.

Current Neuropharmacology, 2011, 9 (1), pp.26

Article dans une revue hal-01384798v1

A Virtual Screening Hit Reveals New Possibilities for Developing Group III Metabotropic Glutamate Receptor Agonists

Chelliah Selvam , Nadia Oueslati , Isabelle Lemasson , Isabelle Brabet , Delphine Rigault et al.

Journal of Medicinal Chemistry, 2010, 53 (7), pp.2797-2813. ⟨10.1021/jm901523t⟩

Article dans une revue hal-05346713v1

Is metabotropic glutamate receptor mGlu4R a good target to treat Parkinson's disease symptoms? Design and evaluation of potent and selective agonists

Isabelle A. Lemasson , Chelliah Selvam , Nadia Oueslati , Isabelle Brabet , Tiphanie Courtiol et al.

Abstracts of Papers of the American Chemical Society, 2009, 238

Article dans une revue hal-01384832v1

LSP1-2111, a new orthosteric group III mGlur agonist with preferential activity on mGluR4, modulates the striatopallidal synapse and alleviates parkinsonian symptoms

C. Beurrier , D. Revy , S. Lopez , M. Lherondel , Cyril Goudet et al.

Neuropharmacology, 2008, 55 (4), pp.587-588. ⟨10.1016/j.neuropharm.2008.06.015⟩

Article dans une revue istex hal-01384860v1

N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.

Yelin Chen , Cyril Goudet , Jean-Philippe Pin , P Jeffrey Conn

Molecular Pharmacology, 2008, 73 (3), pp.909-18. ⟨10.1124/mol.107.040097⟩

Article dans une revue inserm-00318958v1

Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.

Yelin Chen , Yi Nong , Cyril Goudet , Kamondanai Hemstapat , Tomas de Paulis et al.

Molecular Pharmacology, 2007, 71 (5), pp.1389-98. ⟨10.1124/mol.106.032425⟩

Article dans une revue inserm-00319012v1
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Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.

Pauline Sibille , Sébastien Lopez , Isabelle Brabet , Ornella Valenti , Nadia Oueslati et al.

Journal of Medicinal Chemistry, 2007, 50 (15), pp.3585-95. ⟨10.1021/jm070262c⟩

Article dans une revue istex inserm-00318976v1
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Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain

Cyril Goudet , Eric Chapuy , Abdelkrim Alloui , Francine Acher , Jean-Philippe Pin et al.

Pain, 2007, 137 (1), pp.112-124. ⟨10.1016/j.pain.2007.08.020⟩

Article dans une revue inserm-00318859v1
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L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.

Chelliah Selvam , Cyril Goudet , Nadia Oueslati , Jean-Philippe Pin , Francine C. Acher

Journal of Medicinal Chemistry, 2007, 50 (19), pp.4656-64. ⟨10.1021/jm070400y⟩

Article dans une revue istex inserm-00318965v1

D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation.

Eric Trinquet , Michel Fink , Hervé Bazin , Florence Grillet , Fabrice Maurin et al.

Analytical Biochemistry, 2006, 358 (1), pp.126-35. ⟨10.1016/j.ab.2006.08.002⟩

Article dans une revue istex inserm-00318996v1
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Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR.

Veronika Hlavackova , Cyril Goudet , Julie Kniazeff , Alice Zikova , Damien Maurel et al.

EMBO Journal, 2005, 24 (3), pp.499-509. ⟨10.1038/sj.emboj.7600557⟩

Article dans une revue inserm-00318934v1

Allosteric functioning of dimeric class C G-protein-coupled receptors.

Jean-Philippe Pin , Julie Kniazeff , Jianfeng Liu , Virginie Binet , Cyril Goudet et al.

FEBS Journal, 2005, 272, pp.2947-55. ⟨10.1111/j.1742-4658.2005.04728.x⟩

Article dans une revue inserm-00094959v1
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Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators.

Cyril Goudet , Julie Kniazeff , Veronika Hlavackova , Fanny Malhaire , Damien Maurel et al.

Journal of Biological Chemistry, 2005, 280 (26), pp.24380-5. ⟨10.1074/jbc.M502642200⟩

Article dans une revue inserm-00318925v1
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Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.

Cyril Goudet , Florence Gaven , Julie Kniazeff , Claire Vol , Jianfeng Liu et al.

Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (1), pp.378-83. ⟨10.1073/pnas.0304699101⟩

Article dans une revue inserm-00319003v1
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Locking the dimeric GABA(B) G-protein-coupled receptor in its active state.

Julie Kniazeff , Pierre-Philippe Saintot , Cyril Goudet , Jianfeng Liu , Annie Charnet et al.

Journal of Neuroscience, 2004, 24 (2), pp.370-7. ⟨10.1523/JNEUROSCI.3141-03.2004⟩

Article dans une revue hal-00319013v1

Magnesium ions promote assembly of channel-like structures from beticolin o, a non-peptide fungal toxin purified from Cercospora beticola

Cyril Goudet , Anne-Aliénor Véry , M.L. Milat , M. Ildefonse , Jean-Baptiste Thibaud et al.

The Plant Journal, 1998, 14 (3), pp.359-364. ⟨10.1046/j.1365-313X.1998.00129.x⟩

Article dans une revue hal-02690441v1
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Strategies and considerations of G-protein-coupled receptor photopharmacology

Alice Berizzi , Cyril Goudet

Christopher J. Langmead. From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, 88, Elsevier, pp.143-172, 2020, Advances in Pharmacology, 978-0-12-820187-9. ⟨10.1016/bs.apha.2019.12.001⟩

Chapitre d'ouvrage hal-02863838v1