stephane Depil

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Publications

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Type III interferon primes pDCs for TLR7 activation and antagonizes immune suppression mediated by TGF-β and PGE2

Candice Sakref , Alexis Saby , Céline Rodriguez , Maude Ardin , Lyvia Moudombi et al.
Nature Communications, 2025, 16 (1), pp.3045. ⟨10.1038/s41467-025-58220-8⟩
Article dans une revue hal-05021654 v1
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HERV-derived epitopes represent new targets for T-cell-based immunotherapies in ovarian cancer

Paola Bonaventura , Audrey Page , Olivier Tabone , Yann Estornes , Virginie Mutez et al.
Journal for Immunotherapy of Cancer, 2025, 13 (8), pp.e010099. ⟨10.1136/jitc-2024-010099⟩
Article dans une revue hal-05288554 v1

Targeting heterochromatin eliminates chronic myelomonocytic leukemia malignant stem cells through reactivation of retroelements and immune pathways

Donia Hidaoui , Audrey Porquet , Rabie Chelbi , Mathieu Bohm , Aikaterini Polyzou et al.
Communications Biology, 2024, 7 (1), pp.1555. ⟨10.1038/s42003-024-07214-1⟩
Article dans une revue hal-04916245 v1
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Development of NK cell-based cancer immunotherapies through receptor engineering

Audrey Page , Nicolas Chuvin , Jenny Valladeau-Guilemond , Stéphane Depil
Cellular and molecular immunology, 2024, 21, pp.315 - 331. ⟨10.1038/s41423-024-01145-x⟩
Article dans une revue (article de synthèse) hal-04567993 v1
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Endogenous retroelements in hematological malignancies: From epigenetic dysregulation to therapeutic targeting

Mohamed Chour , Françoise Porteu , Stéphane Depil , Vincent Alcazer
American Journal of Hematology, 2024, 100 (1), pp.116-130. ⟨10.1002/ajh.27501⟩
Article dans une revue inserm-04902678 v1
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Pushing the boundaries of radiotherapy-immunotherapy combinations: highlights from the 7 <sup>th</sup> immunorad conference

Pierre-Antoine Laurent , Fabrice André , Alexandre Bobard , Desiree Deandreis , Sandra Demaria et al.
OncoImmunology, 2024, 14, ⟨10.1080/2162402x.2024.2432726⟩
Article dans une revue hal-04940881 v1
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TCR-engineered T cell therapy in solid tumors: State of the art and perspectives

Estelle Baulu , Célia Gardet , Nicolas Chuvin , Stéphane Depil
Science Advances , 2023, 9 (7), ⟨10.1126/sciadv.adf3700⟩
Article dans une revue hal-04115921 v1
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Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor

Benjamin Ducarouge , Anna-Rita Redavid , Camille Victoor , Ruxanda Chira , Aurélien Fonseca et al.
Cell Death and Differentiation, 2023, 30 (10), pp.2201-2212. ⟨10.1038/s41418-023-01209-x⟩
Article dans une revue hal-04253805 v1
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Tumour burden and antigen-specific T cell magnitude represent major parameters for clinical response to cancer vaccine and TCR-engineered T cell therapy

Marion Mallet , Rasha Boulos , Vincent Alcazer , Paola Bonaventura , Yann Estornes et al.
European Journal of Cancer, 2022, 171, pp.96-105. ⟨10.1016/j.ejca.2022.05.008⟩
Article dans une revue hal-03784075 v1
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Radiotherapy as a means to increase the efficacy of T-cell therapy in solid tumors

Pierre-Antoine Laurent , Daphne Morel , Lydia Meziani , Stéphane Depil , Eric Deutsch
OncoImmunology, 2022, 12 (1), pp.2158013. ⟨10.1080/2162402x.2022.2158013⟩
Article dans une revue (article de synthèse) hal-04482410 v1
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HERVs characterize normal and leukemia stem cells and represent a source of shared epitopes for cancer immunotherapy

Vincent Alcazer , Paola Bonaventura , Laurie Tonon , Emilie Michel , Virginie Mutez et al.
American Journal of Hematology, 2022, 97 (9), pp.1200-1214. ⟨10.1002/ajh.26647⟩
Article dans une revue hal-03855460 v1
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Identification of shared tumor epitopes from endogenous retroviruses inducing high-avidity cytotoxic T cells for cancer immunotherapy

Paola Bonaventura , Vincent Alcazer , Virginie Mutez , Laurie Tonon , Juliette Martin et al.
Science Advances , 2022, 8 (4), ⟨10.1126/sciadv.abj3671⟩
Article dans une revue hal-03552937 v1
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Approches d’immunothérapie cellulaire T dans les tumeurs solides

Estelle Baulu , Aurore Dougé , Nicolas Chuvin , Jacques-Olivier Bay , Stéphane Depil
Bulletin du Cancer, 2021, 108 (10), pp.S96-S108. ⟨10.1016/j.bulcan.2021.06.004⟩
Article dans une revue hal-03784069 v1
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Développement des CAR-T allogéniques

Vincent Alcazer , Stéphane Depil
Bulletin du Cancer, 2021, 108 (10), pp.S73-S80. ⟨10.1016/j.bulcan.2021.01.025⟩
Article dans une revue hal-03784063 v1
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Les lymphocytes T CD4 + jouent un rôle majeur dans la réponse immunitaire antitumorale

Lucie Leclair , Stéphane Depil
Médecine/Sciences, 2021, 37 (6-7), pp.671-673. ⟨10.1051/medsci/2021075⟩
Article dans une revue hal-03784058 v1

‘Off-the-shelf’ allogeneic CAR T cells: development and challenges

S. Depil , P. Duchateau , S. Grupp , G. Mufti , L. Poirot
Nature Reviews Drug Discovery, 2020, 19 (3), pp.185-199. ⟨10.1038/s41573-019-0051-2⟩
Article dans une revue hal-03784053 v1
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Human Endogenous Retroviruses (HERVs): Shaping the Innate Immune Response in Cancers

Vincent Alcazer , Paola Bonaventura , Stéphane Depil
Cancers, 2020, 12 (3), pp.610. ⟨10.3390/cancers12030610⟩
Article dans une revue (article de synthèse) hal-03784048 v1

Granulocyte–macrophage colony-stimulating factor inactivation in CAR T-cells prevents monocyte-dependent release of key cytokine release syndrome mediators

Mohit Sachdeva , Philippe Duchateau , Stéphane Depil , Laurent Poirot , Julien Valton
Journal of Biological Chemistry, 2019, 294 (14), pp.5430-5437. ⟨10.1074/jbc.AC119.007558⟩
Article dans une revue hal-03784028 v1
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Cancer vaccines: what’s next?

Stéphane Depil , Paola Bonaventura , Vincent Alcazer
Oncotarget, 2019, 10 (40), pp.3985-3987. ⟨10.18632/oncotarget.27006⟩
Article dans une revue hal-03784033 v1
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Repurposing rotavirus vaccines for intratumoral immunotherapy can overcome resistance to immune checkpoint blockade

Tala Shekarian , Eva Sivado , Anne-Catherine Jallas , Stéphane Depil , Janice Kielbassa et al.
Science Translational Medicine, 2019, 11 (515), pp.eaat5025. ⟨10.1126/scitranslmed.aat5025⟩
Article dans une revue hal-02347852 v1
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Modulation of chimeric antigen receptor surface expression by a small molecule switch

Alexandre Juillerat , Diane Tkach , Brian Busser , Sonal Temburni , Julien Valton et al.
BMC Biotechnology, 2019, 19 (1), pp.44. ⟨10.1186/s12896-019-0537-3⟩
Article dans une revue hal-03784035 v1
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Cold Tumors: A Therapeutic Challenge for Immunotherapy

Paola Bonaventura , Tala Shekarian , Vincent Alcazer , Jenny Valladeau-Guilemond , Sandrine Valsesia-Wittmann et al.
Frontiers in Immunology, 2019, 10, pp.168. ⟨10.3389/fimmu.2019.00168⟩
Article dans une revue (article de synthèse) hal-03769056 v1

Cancer-Associated Fibroblasts Produce Netrin-1 to Control Cancer Cell Plasticity

Pei-Ju Sung , Nicolas Rama , Jeromine Imbach , Stephany Fiore , Benjamin Ducarouge et al.
Cancer Research, 2019, 79 (14), pp.3651-3661. ⟨10.1158/0008-5472.CAN-18-2952⟩
Article dans une revue hal-02323505 v1

Pattern recognition receptors: immune targets to enhance cancer immunotherapy

Tala Shekarian , Sandrine Valsesia-Wittmann , J. Brody , Marie-Cécile Michallet , Stéphane Depil et al.
Annals of Oncology, 2019, 30 (12), pp.2017. ⟨10.1093/annonc/mdz225⟩
Article dans une revue hal-03784051 v1
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Neoepitopes-based vaccines: challenges and perspectives

Vincent Alcazer , Paola Bonaventura , Laurie Tonon , Sandrine Wittmann , Christophe Caux et al.
European Journal of Cancer, 2019, 108, pp.55 - 60. ⟨10.1016/j.ejca.2018.12.011⟩
Article dans une revue hal-03486167 v1
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Développement des CAR-T dans les tumeurs solides

Vincent Alcazer , Christophe Delenda , Laurent Poirot , Stéphane Depil
Bulletin du Cancer, 2018, 105, pp.S178 - S187. ⟨10.1016/S0007-4551(19)30048-7⟩
Article dans une revue hal-03486670 v1

Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers

M. Grandin , M. Meier , J.G. Delcros , D. Nikodemus , R. Reuten et al.
Cancer Cell, 2016, 29, pp.173-185. ⟨10.1016/j.ccell.2016.01.001⟩
Article dans une revue hal-01792608 v1

HDAC inhibition does not induce estrogen receptor in human triple-negative breast cancer cell lines and patient-derived xenografts

Patricia De Cremoux , Mathieu Dalvai , Olivia N'Doye , Fatima Moutahir , Gaëlle Rolland et al.
Breast Cancer Research and Treatment, 2015, 149 (1), pp.81-89. ⟨10.1007/s10549-014-3233-y⟩
Article dans une revue hal-03653860 v1
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Decoding and unlocking the BCL‐2 dependency of cancer cells

Philippe Juin , Olivier Geneste , Fabien Gautier , Stéphane Depil , Mario Campone
Nature Reviews Cancer, 2013, 13 (7), pp.455-465. ⟨10.1038/nrc3538⟩
Article dans une revue inserm-02481124 v1

EBV Latency II-derived Peptides Induce A Specific CD4+ Cytotoxic T-cell Activity and Not A CD4+ Regulatory T-cell Response

Olivier Moralès , Stéphane Depil , Dhafer Mrizak , Nathalie Martin , Papa Alioune Ndour et al.
Journal of Immunotherapy, 2012, 35 (3), pp.254-266. ⟨10.1097/CJI.0b013e31824d72c5⟩
Article dans une revue hal-03059998 v1

Off-the-Shelf Allogeneic CAR-T Cells or Other Immune Effector Cells

Stéphane Depil , Waseem Qasim
The EBMT/EHA CAR-T Cell Handbook, Springer International Publishing, pp.51-54, 2022, ⟨10.1007/978-3-030-94353-0_9⟩
Chapitre d'ouvrage hal-03784072 v1

Integrative approaches for the identification of therapeutic targets in basal-like breast cancer from multi-level molecular data

B. M. Tesson , Guillem Rigaill , D. Gentien , S. Roman-Roman , F. Cruzalegui et al.
22. Biennial Congress of the European Association for Cancer Research, Jul 2012, Barcelone, Spain. Elsevier Science LTD, European Journal of Cancer, 48 (Suppl. 5), 2012, European Journal of Cancer
Poster de conférence hal-01189748 v1