stephane Depil

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HERV-derived epitopes represent new targets for T-cell-based immunotherapies in ovarian cancer

Paola Bonaventura , Audrey Page , Olivier Tabone , Yann Estornes , Virginie Mutez et al.

Journal for Immunotherapy of Cancer, 2025, 13 (8), pp.e010099. ⟨10.1136/jitc-2024-010099⟩

Article dans une revue hal-05288554v1
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Type III interferon primes pDCs for TLR7 activation and antagonizes immune suppression mediated by TGF-β and PGE2

Candice Sakref , Alexis Saby , Céline Rodriguez , Maude Ardin , Lyvia Moudombi et al.

Nature Communications, 2025, 16 (1), pp.3045. ⟨10.1038/s41467-025-58220-8⟩

Article dans une revue hal-05021654v1

Targeting heterochromatin eliminates chronic myelomonocytic leukemia malignant stem cells through reactivation of retroelements and immune pathways

Donia Hidaoui , Audrey Porquet , Rabie Chelbi , Mathieu Bohm , Aikaterini Polyzou et al.

Communications Biology, 2024, 7 (1), pp.1555. ⟨10.1038/s42003-024-07214-1⟩

Article dans une revue hal-04916245v1
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Endogenous retroelements in hematological malignancies: From epigenetic dysregulation to therapeutic targeting

Mohamed Chour , Françoise Porteu , Stéphane Depil , Vincent Alcazer

American Journal of Hematology, 2024, 100 (1), pp.116-130. ⟨10.1002/ajh.27501⟩

Article dans une revue inserm-04902678v1
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Development of NK cell-based cancer immunotherapies through receptor engineering

Audrey Page , Nicolas Chuvin , Jenny Valladeau-Guilemond , Stéphane Depil

Cellular and molecular immunology, 2024, 21, pp.315 - 331. ⟨10.1038/s41423-024-01145-x⟩

Article dans une revue (article de synthèse) hal-04567993v1
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Pushing the boundaries of radiotherapy-immunotherapy combinations: highlights from the 7 <sup>th</sup> immunorad conference

Pierre-Antoine Laurent , Fabrice André , Alexandre Bobard , Desiree Deandreis , Sandra Demaria et al.

OncoImmunology, 2024, 14, ⟨10.1080/2162402x.2024.2432726⟩

Article dans une revue hal-04940881v1
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Targeting Heterochromatin Eliminates Malignant Hematopoietic Stem and Progenitor Cells in Chronic Myelomonocytic Leukemia Through Reactivation of Retroelements and Innate Immune pathways

Donia Hidaoui , Rabie Chelbie , Mathieu Bohm , Audrey Porquet , Aikaterini Polyzou et al.

Communications Biology, 2024, 7, pp.1555. ⟨10.1038/s42003-024-07214-1⟩

Article dans une revue hal-04471048v1
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TCR-engineered T cell therapy in solid tumors: State of the art and perspectives

Estelle Baulu , Célia Gardet , Nicolas Chuvin , Stéphane Depil

Science Advances , 2023, 9 (7), ⟨10.1126/sciadv.adf3700⟩

Article dans une revue hal-04115921v1
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Netrin-1 blockade inhibits tumor associated Myeloid-derived suppressor cells, cancer stemness and alleviates resistance to chemotherapy and immune checkpoint inhibitor

Benjamin Ducarouge , Anna-Rita Redavid , Camille Victoor , Ruxanda Chira , Aurélien Fonseca et al.

Cell Death and Differentiation, 2023, 30 (10), pp.2201-2212. ⟨10.1038/s41418-023-01209-x⟩

Article dans une revue hal-04253805v1
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Radiotherapy as a means to increase the efficacy of T-cell therapy in solid tumors

Pierre-Antoine Laurent , Daphne Morel , Lydia Meziani , Stéphane Depil , Eric Deutsch

OncoImmunology, 2022, 12 (1), pp.2158013. ⟨10.1080/2162402x.2022.2158013⟩

Article dans une revue (article de synthèse) hal-04482410v1
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Identification of shared tumor epitopes from endogenous retroviruses inducing high-avidity cytotoxic T cells for cancer immunotherapy

Paola Bonaventura , Vincent Alcazer , Virginie Mutez , Laurie Tonon , Juliette Martin et al.

Science Advances , 2022, 8 (4), ⟨10.1126/sciadv.abj3671⟩

Article dans une revue hal-03552937v1
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HERVs characterize normal and leukemia stem cells and represent a source of shared epitopes for cancer immunotherapy

Vincent Alcazer , Paola Bonaventura , Laurie Tonon , Emilie Michel , Virginie Mutez et al.

American Journal of Hematology, 2022, 97 (9), pp.1200-1214. ⟨10.1002/ajh.26647⟩

Article dans une revue hal-03855460v1
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Tumour burden and antigen-specific T cell magnitude represent major parameters for clinical response to cancer vaccine and TCR-engineered T cell therapy

Marion Mallet , Rasha Boulos , Vincent Alcazer , Paola Bonaventura , Yann Estornes et al.

European Journal of Cancer, 2022, 171, pp.96-105. ⟨10.1016/j.ejca.2022.05.008⟩

Article dans une revue hal-03784075v1
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Développement des CAR-T allogéniques

Vincent Alcazer , Stéphane Depil

Bulletin du Cancer, 2021, 108 (10), pp.S73-S80. ⟨10.1016/j.bulcan.2021.01.025⟩

Article dans une revue hal-03784063v1
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Approches d’immunothérapie cellulaire T dans les tumeurs solides

Estelle Baulu , Aurore Dougé , Nicolas Chuvin , Jacques-Olivier Bay , Stéphane Depil

Bulletin du Cancer, 2021, 108 (10), pp.S96-S108. ⟨10.1016/j.bulcan.2021.06.004⟩

Article dans une revue hal-03784069v1
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Les lymphocytes T CD4 + jouent un rôle majeur dans la réponse immunitaire antitumorale

Lucie Leclair , Stéphane Depil

Médecine/Sciences, 2021, 37 (6-7), pp.671-673. ⟨10.1051/medsci/2021075⟩

Article dans une revue hal-03784058v1

‘Off-the-shelf’ allogeneic CAR T cells: development and challenges

S. Depil , P. Duchateau , S. Grupp , G. Mufti , L. Poirot

Nature Reviews Drug Discovery, 2020, 19 (3), pp.185-199. ⟨10.1038/s41573-019-0051-2⟩

Article dans une revue hal-03784053v1
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Human Endogenous Retroviruses (HERVs): Shaping the Innate Immune Response in Cancers

Vincent Alcazer , Paola Bonaventura , Stéphane Depil

Cancers, 2020, 12 (3), pp.610. ⟨10.3390/cancers12030610⟩

Article dans une revue (article de synthèse) hal-03784048v1
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Cancer vaccines: what’s next?

Stéphane Depil , Paola Bonaventura , Vincent Alcazer

Oncotarget, 2019, 10 (40), pp.3985-3987. ⟨10.18632/oncotarget.27006⟩

Article dans une revue hal-03784033v1
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Modulation of chimeric antigen receptor surface expression by a small molecule switch

Alexandre Juillerat , Diane Tkach , Brian Busser , Sonal Temburni , Julien Valton et al.

BMC Biotechnology, 2019, 19 (1), pp.44. ⟨10.1186/s12896-019-0537-3⟩

Article dans une revue hal-03784035v1
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Repurposing rotavirus vaccines for intratumoral immunotherapy can overcome resistance to immune checkpoint blockade

Tala Shekarian , Eva Sivado , Anne-Catherine Jallas , Stéphane Depil , Janice Kielbassa et al.

Science Translational Medicine, 2019, 11 (515), pp.eaat5025. ⟨10.1126/scitranslmed.aat5025⟩

Article dans une revue hal-02347852v1

Cancer-Associated Fibroblasts Produce Netrin-1 to Control Cancer Cell Plasticity

Pei-Ju Sung , Nicolas Rama , Jeromine Imbach , Stephany Fiore , Benjamin Ducarouge et al.

Cancer Research, 2019, 79 (14), pp.3651-3661. ⟨10.1158/0008-5472.CAN-18-2952⟩

Article dans une revue hal-02323505v1
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Cold Tumors: A Therapeutic Challenge for Immunotherapy

Paola Bonaventura , Tala Shekarian , Vincent Alcazer , Jenny Valladeau-Guilemond , Sandrine Valsesia-Wittmann et al.

Frontiers in Immunology, 2019, 10, pp.168. ⟨10.3389/fimmu.2019.00168⟩

Article dans une revue (article de synthèse) hal-03769056v1

Pattern recognition receptors: immune targets to enhance cancer immunotherapy

Tala Shekarian , Sandrine Valsesia-Wittmann , J. Brody , Marie-Cécile Michallet , Stéphane Depil et al.

Annals of Oncology, 2019, 30 (12), pp.2017. ⟨10.1093/annonc/mdz225⟩

Article dans une revue hal-03784051v1
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Neoepitopes-based vaccines: challenges and perspectives

Vincent Alcazer , Paola Bonaventura , Laurie Tonon , Sandrine Wittmann , Christophe Caux et al.

European Journal of Cancer, 2019, 108, pp.55 - 60. ⟨10.1016/j.ejca.2018.12.011⟩

Article dans une revue hal-03486167v1

Granulocyte–macrophage colony-stimulating factor inactivation in CAR T-cells prevents monocyte-dependent release of key cytokine release syndrome mediators

Mohit Sachdeva , Philippe Duchateau , Stéphane Depil , Laurent Poirot , Julien Valton

Journal of Biological Chemistry, 2019, 294 (14), pp.5430-5437. ⟨10.1074/jbc.AC119.007558⟩

Article dans une revue hal-03784028v1
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Développement des CAR-T dans les tumeurs solides

Vincent Alcazer , Christophe Delenda , Laurent Poirot , Stéphane Depil

Bulletin du Cancer, 2018, 105, pp.S178 - S187. ⟨10.1016/S0007-4551(19)30048-7⟩

Article dans une revue hal-03486670v1

Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers

M. Grandin , M. Meier , J.G. Delcros , D. Nikodemus , R. Reuten et al.

Cancer Cell, 2016, 29, pp.173-185. ⟨10.1016/j.ccell.2016.01.001⟩

Article dans une revue hal-01792608v1

HDAC inhibition does not induce estrogen receptor in human triple-negative breast cancer cell lines and patient-derived xenografts

Patricia De Cremoux , Mathieu Dalvai , Olivia N'Doye , Fatima Moutahir , Gaëlle Rolland et al.

Breast Cancer Research and Treatment, 2015, 149 (1), pp.81-89. ⟨10.1007/s10549-014-3233-y⟩

Article dans une revue hal-03653860v1
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Decoding and unlocking the BCL‐2 dependency of cancer cells

Philippe Juin , Olivier Geneste , Fabien Gautier , Stéphane Depil , Mario Campone

Nature Reviews Cancer, 2013, 13 (7), pp.455-465. ⟨10.1038/nrc3538⟩

Article dans une revue inserm-02481124v1

EBV Latency II-derived Peptides Induce A Specific CD4+ Cytotoxic T-cell Activity and Not A CD4+ Regulatory T-cell Response

Olivier Moralès , Stéphane Depil , Dhafer Mrizak , Nathalie Martin , Papa Alioune Ndour et al.

Journal of Immunotherapy, 2012, 35 (3), pp.254-266. ⟨10.1097/CJI.0b013e31824d72c5⟩

Article dans une revue hal-03059998v1

Off-the-Shelf Allogeneic CAR-T Cells or Other Immune Effector Cells

Stéphane Depil , Waseem Qasim

The EBMT/EHA CAR-T Cell Handbook, Springer International Publishing, pp.51-54, 2022, ⟨10.1007/978-3-030-94353-0_9⟩

Chapitre d'ouvrage hal-03784072v1

Integrative approaches for the identification of therapeutic targets in basal-like breast cancer from multi-level molecular data

B. M. Tesson , Guillem Rigaill , D. Gentien , S. Roman-Roman , F. Cruzalegui et al.

22. Biennial Congress of the European Association for Cancer Research, Jul 2012, Barcelone, Spain. Elsevier Science LTD, European Journal of Cancer, 48 (Suppl. 5), 2012, European Journal of Cancer

Poster de conférence hal-01189748v1