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Dimitra Gkika

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Publications

Editorial: From mechanosensing to signalling and cell response: The ion channel force

Dimitra Gkika , Albrecht Schwab
Frontiers in Cell and Developmental Biology, 2023, 11, ⟨10.3389/fcell.2023.1183726⟩
Journal articles hal-04361631v1

TRP Channels: The Neglected Culprits in Breast Cancer Chemotherapy Resistance?

Mayar Soussi , Alice Hasselsweiller , Dimitra Gkika
Membranes, 2023, 13 (9), pp.788. ⟨10.3390/membranes13090788⟩
Journal articles hal-04361627v1

TRPM8 as an Anti–Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination

Dimitra Gkika , Stéphane Lolignier , Guillaume Grolez , Alexis Bavencoffe , Georges Shapovalov
International Journal of Molecular Sciences, 2022, 23 (12), pp.6672. ⟨10.3390/ijms23126672⟩
Journal articles hal-04038958v1
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TRPM8 as an Anti–Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination

Guillaume Grolez , Giorgia Chinigò , Alexandre Barras , Mehdi Hammadi , Lucile Noyer
International Journal of Molecular Sciences, 2022, Calcium Signaling in Human Health and Diseases 3.0, 23 (12), pp.6672. ⟨10.3390/ijms23126672⟩
Journal articles hal-03746647v1
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TRPM8-Rap1A Interaction Sites as Critical Determinants for Adhesion and Migration of Prostate and Other Epithelial Cancer Cells

Giorgia Chinigò , Guillaume Grolez , Madelaine Audero , Alexandre Bokhobza , Michela Bernardini
Cancers, 2022, 14 (9), pp.2261. ⟨10.3390/cancers14092261⟩
Journal articles hal-03842400v1
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TRPC3 shapes the ER-mitochondria Ca2+ transfer characterizing tumour-promoting senescence

Valerio Farfariello , Dmitri Gordienko , Lina Mesilmany , Yasmine Touil , Emmanuelle Germain
Nature Communications, 2022, 13 (1), pp.956. ⟨10.1038/s41467-022-28597-x⟩
Journal articles hal-03666578v1
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TRP Channels in Brain Tumors

Giorgia Chinigò , Hélène Castel , Oana Chever , Dimitra Gkika
Frontiers in Cell and Developmental Biology, 2021, 9 (617801), pp.1-17. ⟨10.3389/fcell.2021.617801⟩
Journal articles hal-04503098v1

Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening

Valerio Farfariello , Natalia Prevarskaya , Dimitra Gkika
Reviews of Physiology Biochemistry and Pharmacology, 2020, Reviews of Physiology, Biochemistry and Pharmacology, 181, pp.39-56. ⟨10.1007/112_2020_22⟩
Journal articles hal-04503116v1

The Two-Way Relationship Between Calcium and Metabolism in Cancer

Camille Dejos , Dimitra Gkika , Anna Rita Cantelmo
Frontiers in Cell and Developmental Biology, 2020, 8, ⟨10.3389/fcell.2020.573747⟩
Journal articles hal-04503102v1
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Testosterone‐androgen receptor: The steroid link inhibiting TRPM8‐mediated cold sensitivity

Dimitra Gkika , Stéphane Lolignier , Guillaume Grolez , Alexis Bavencoffe , Georges Shapovalov
FASEB Journal, 2020, 34 (6), pp.7483-7499. ⟨10.1096/fj.201902270R⟩
Journal articles hal-03512394v1
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TRP Channels and Small GTPases Interplay in the Main Hallmarks of Metastatic Cancer

Giorgia Chinigò , Alessandra Fiorio Pla , Dimitra Gkika
Frontiers in Pharmacology, 2020, 11 (581455), pp.1-16. ⟨10.3389/fphar.2020.581455⟩
Journal articles hal-04503106v1

Ca2+ Channel Toolkit in Neuroendocrine Tumors

Alessandra Fiorio Pla , Dimitra Gkika
Neuroendocrinology, 2020, 110 (1-2), pp.147-154. ⟨10.1159/000501397⟩
Journal articles hal-04503120v1
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Partners in Crime: Towards New Ways of Targeting Calcium Channels

Lucile Noyer , Loic Lemonnier , Pascal Mariot , Dimitra Gkika
International Journal of Molecular Sciences, 2019, 20 (24), pp.6344. ⟨10.3390/ijms20246344⟩
Journal articles hal-04210077v1
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TRPM8-androgen receptor association within lipid rafts promotes prostate cancer cell migration

Guillaume P. Grolez , Dmitri V. Gordiendko , Manon Clarisse , Mehdi Hammadi , Emilie Desruelles
Cell Death and Disease, 2019, 10 (9), pp.652. ⟨10.1038/s41419-019-1891-8⟩
Journal articles hal-03133861v1
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TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia

Fabien Vanden Abeele , Sabine Lotteau , Sylvie Ducreux , Charlotte Dubois , Nicole Monnier
Genetics in Medicine, 2019, 21 (2), pp.441-450. ⟨10.1038/s41436-018-0066-9⟩
Journal articles hal-02475163v1

Transient Receptor Potential Channel Expression Signatures in Tumor-Derived Endothelial Cells: Functional Roles in Prostate Cancer Angiogenesis

Michela Bernardini , Alessia Brossa , Giorgia Chinigo , Guillaume Grolez , Giulia Trimaglio
Cancers, 2019, 11 (7), pp.956. ⟨10.3390/cancers11070956⟩
Journal articles hal-02404061v1

TRPM8 and prostate: a cold case?

Lucile Noyer , Guillaume Grolez , Natalia Prevarskaya , Dimitra Gkika , Loic Lemonnier
Pflügers Archiv European Journal of Physiology, 2018, 470 (10), pp.1419-1429. ⟨10.1007/s00424-018-2169-1⟩
Journal articles hal-04503124v1

4TM-TRPM8 channels are new gatekeepers of the ER-mitochondria Ca2+ transfer

Gabriel Bidaux , Dmitri Gordienko , George Shapovalov , Valerio Farfariello , Anne-Sophie Borowiec
Biochimica et Biophysica Acta - Molecular Cell Research, 2018, 1865 (7), pp.981-994. ⟨10.1016/j.bbamcr.2018.04.007⟩
Journal articles hal-01847399v1

TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1

Tullio Genova , Guillaume Grolez , Chiara Camillo , Michela Bernardini , Alexandre Bokhobza
Journal of Cell Biology, 2017, 216 (7), pp.2107-2130. ⟨10.1083/jcb.201506024⟩
Journal articles hal-04038990v1
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Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference

David Arredondo Zamarripa , Ramsés Noguez Imm , Ana María Bautista Cortés , Osvaldo Vázquez Ruíz , Michela Bernardini
Scientific Reports, 2017, 7 (1), pp.13094. ⟨10.1038/s41598-017-13621-8⟩
Journal articles hal-04038979v1
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TRPM8 Puts the Chill on Prostate Cancer

Guillaume P. Grolez , Dimitra Gkika
Pharmaceuticals, 2016, 9 (3), pp.44. ⟨10.3390/ph9030044⟩
Journal articles hal-04503126v1
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New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives

Stéphane Lolignier , Dimitra Gkika , David Andersson , Enrico Leipold , Irina Vetter
Journal of Neuroscience, 2016, 36 (45), pp.11435 - 11439. ⟨10.1523/jneurosci.2327-16.2016⟩
Journal articles hal-03512571v1

Human transient receptor potential (TRP) channel expression profiling in carcinogenesis

Michela Bernardini , Alessandra Fiorio Pla , Natalia Prevarskaya , Dimitra Gkika
International Journal of Developmental Biology, 2015, 59 (7-8-9), pp.399-406. ⟨10.1387/ijdb.150232dg⟩
Journal articles hal-04039012v1
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TRP channel–associated factors are a novel protein family that regulates TRPM8 trafficking and activity

Dimitra Gkika , Loic Lemonnier , George Shapovalov , Dmitri Gordienko , Céline Poux
Journal of Cell Biology, 2015, 208 (1), pp.89-107. ⟨10.1083/jcb.201402076⟩
Journal articles hal-01111024v1
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Differential sensitivity of prostate tumor derived endothelial cells to sorafenib and sunitinib

Alessandra Fiorio Pla , Alessia Brossa , Michela Bernardini , Tullio Genova , Guillaume Grolez
BMC Cancer, 2014, 14 (1), pp.939. ⟨10.1186/1471-2407-14-939⟩
Journal articles hal-04039024v1

Remodeling of Channel-Forming ORAI Proteins Determines an Oncogenic Switch in Prostate Cancer

Charlotte Dubois , Fabien Vanden Abeele , V’yacheslav Lehen’kyi , Dimitra Gkika , Basma Guarmit
Cancer Cell, 2014, 26 (1), pp.19-32. ⟨10.1016/j.ccr.2014.04.025⟩
Journal articles hal-04039033v1

TRPV2 Mediates Adrenomedullin Stimulation of Prostate and Urothelial Cancer Cell Adhesion, Migration and Invasion

Agathe Oulidi , Alexandre Bokhobza , Dimitra Gkika , Fabien Vanden Abeele , V’yacheslav Lehen’kyi
PLoS ONE, 2013, 8 (5), pp.e64885. ⟨10.1371/journal.pone.0064885⟩
Journal articles hal-04039050v1
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Differential sensitivity of prostate tumor derived endothelial cells to sorafenib and sunitinib.

Alessandra Fiorio Pla , Alessia Brossa , Michela Bernardini , Tullio Genova , Guillaume Grolez
BMC Cancer, 2013, 14 (1), pp.939
Journal articles inserm-01122893v1

Emerging role of TRP channels in cell migration: from tumor vascularization to metastasis

Alessandra Fiorio Pla , Dimitra Gkika
Frontiers in Physiology, 2013, 4, ⟨10.3389/fphys.2013.00311⟩
Journal articles hal-04503128v1

Complex modulation of the cold receptor TRPM8 by volatile anaesthetics and its role in complications of general anaesthesia

Fabien Vanden Abeele , Artem Kondratskyi , Charlotte Dubois , George Shapovalov , Dimitra Gkika
Journal of Cell Science, 2013, 126 (19), pp.4479-4489. ⟨10.1242/jcs.131631⟩
Journal articles hal-04039037v1

Opiates Modulate Thermosensation by Internalizing Cold Receptor TRPM8

George Shapovalov , Dimitra Gkika , Maily Devilliers , Artem Kondratskyi , Dmitri Gordienko
Cell Reports, 2013, 4 (3), pp.504-515. ⟨10.1016/j.celrep.2013.07.002⟩
Journal articles hal-04039045v1
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TRPV2 Mediates Adrenomedullin Stimulation of Prostate and Urothelial Cancer Cell Adhesion, Migration and Invasion

Agathe Oulidi , Alexandre Bokhobza , Dimitra Gkika , Fabien Vanden Abeele , V'Yacheslav Lehen'Kyi
PLoS ONE, 2013, 8 (5), pp.e64885. ⟨10.1371/journal.pone.0064885⟩
Journal articles hal-01708095v1

TRP channels in prostate cancer: the good, the bad and the ugly?

Dimitra Gkika , Natalia Prevarskaya
Asian Journal of Andrology, 2011, 13 (5), pp.673-676. ⟨10.1038/aja.2011.18⟩
Journal articles hal-04503134v1

From urgency to frequency: facts and controversies of TRPs in the lower urinary tract

Roman Skryma , Natalia Prevarskaya , Dimitra Gkika , Yaroslav Shuba
Nature Reviews Urology, 2011, 8 (11), pp.617-630. ⟨10.1038/nrurol.2011.142⟩
Journal articles hal-04503131v1

Complex Regulation of the TRPM8 Cold Receptor Channel

Alexis Bavencoffe , Artem Kondratskyi , Dimitra Gkika , Brigitte Mauroy , Yaroslav Shuba
Journal of Biological Chemistry, 2011, 286 (11), pp.9849-9855. ⟨10.1074/jbc.M110.162016⟩
Journal articles hal-04039058v1

Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance

Michaël Monet , V'Yacheslav Lehen'Kyi , Florian Gackiere , Virginie Firlej , Matthieu Vandenberghe
Cancer Research, 2010, 285 (13), pp.9410-9419. ⟨10.1158/0008-5472.CAN-09-2205⟩
Journal articles hal-04039081v1
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PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression.

Dimitra Gkika , Matthieu Flourakis , Loic Lemonnier , Natalia Prevarskaya
Oncogene, 2010, epub ahead of print. ⟨10.1038/onc.2010.210⟩
Journal articles inserm-00492444v1

PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression

Dimitra Gkika , M Flourakis , L Lemonnier , N Prevarskaya
Oncogene, 2010, 29 (32), pp.4611-4616. ⟨10.1038/onc.2010.210⟩
Journal articles hal-04039061v1
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The Transient Receptor Potential Channel TRPM8 Is Inhibited via the α2A Adrenoreceptor Signaling Pathway

Alexis Bavencoffe , Dimitra Gkika , Artem Kondratskyi , Benjamin Beck , Anne-Sophie Borowiec
Journal of Biological Chemistry, 2010, 285 (13), pp.9410-9419. ⟨10.1074/jbc.M109.069377⟩
Journal articles hal-03060332v1

Molecular mechanisms of TRP regulation in tumor growth and metastasis

Dimitra Gkika , Natalia Prevarskaya
Biochimica et Biophysica Acta - Molecular Cell Research, 2009, 1793 (6), pp.953-958. ⟨10.1016/j.bbamcr.2008.11.010⟩
Journal articles hal-04503178v1

Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation

Michaël Monet , Dimitra Gkika , V'Yacheslav Lehen'Kyi , Albin Pourtier , Fabien Vanden Abeele
Biochimica et Biophysica Acta - Molecular Cell Research, 2009, 1793 (3), pp.528-539. ⟨10.1016/j.bbamcr.2009.01.003⟩
Journal articles hal-04039097v1

Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function

Dimitra Gkika , Catalin Topala , Qing Chang , Nicolas Picard , Stéphanie Thébault
Journal of Clinical Investigation, 2007, 117 (6), pp.1647-1657. ⟨10.1172/JCI30168⟩
Journal articles hal-04039106v1
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Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function.

Gabriel Bidaux , Matthieu Flourakis , Stéphanie Thebault , Alexander Zholos , Benjamin Beck
Journal of Clinical Investigation, 2007, 117 (6), pp.1647-57. ⟨10.1172/JCI30168⟩
Journal articles inserm-00137718v1
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Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function

Gabriel Bidaux , Matthieu Flourakis , Stéphanie Thebault , Alexander Zholos , Benjamin Beck
Journal of Clinical Investigation, 2007, 117 (6), pp.1647-1657. ⟨10.1172/JCI30168⟩
Journal articles hal-03060259v1

Tissue kallikrein stimulates Ca2+ reabsorption via PKC-dependent plasma membrane accumulation of TRPV5

Dimitra Gkika , Catalin Topala , Qing Chang , Nicolas Picard , Stéphanie Thébault
EMBO Journal, 2006, 25 (20), pp.4707-4716. ⟨10.1038/sj.emboj.7601357⟩
Journal articles hal-04040053v1

The immunophilin FKBP52 inhibits the activity of the epithelial Ca 2+ channel TRPV5

Dimitra Gkika , Catalin Topala , Joost Hoenderop , René Bindels
American Journal of Physiology. Renal Physiology, 2006, 290 (5), pp.F1253-F1259. ⟨10.1152/ajprenal.00298.2005⟩
Journal articles hal-04040056v1

Critical Role of the Epithelial Ca2+ Channel TRPV5 in Active Ca2+ Reabsorption as Revealed by TRPV5/Calbindin-D28K Knockout Mice

Dimitra Gkika , Yu-Juei Hsu , Annemiete van der Kemp , Sylvia Christakos , René Bindels
Journal of the American Society of Nephrology, 2006, 17 (11), pp.3020-3027. ⟨10.1681/ASN.2006060676⟩
Journal articles hal-04040054v1

Regulation of gene expression by dietary Ca2+ in kidneys of 25-hydroxyvitamin D3-1α-hydroxylase knockout mice

Joost G.J. Hoenderop , Helena Chon , Dimitra Gkika , Hans A.R. Bluyssen , Frank C.P. Holstege
Kidney International, 2004, 65 (2), pp.531-539. ⟨10.1111/j.1523-1755.2004.00402.x⟩
Journal articles hal-04040079v1

80K-H as a New Ca2+ Sensor Regulating the Activity of the Epithelial Ca2+ Channel Transient Receptor Potential Cation Channel V5 (TRPV5)

Dimitra Gkika , Frank Mahieu , Bernd Nilius , Joost G.J. Hoenderop , René J.M. Bindels
Journal of Biological Chemistry, 2004, 279 (25), pp.26351-26357. ⟨10.1074/jbc.M403801200⟩
Journal articles hal-04040058v1

Functional expression of the epithelial Ca2+ channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex

S. F.J. van de Graaf , Stan F J van De Graaf , Joost G J Hoenderop , Dimitra Gkika , Dennis Lamers
EMBO Journal, 2003, 22 (7), pp.1478-1487. ⟨10.1093/emboj/cdg162⟩
Journal articles hal-04040078v1

A novel myeloid-like NK cell progenitor in human umbilical cord blood

Sonia Perez , Panagiota Sotiropoulou , Dimitra Gkika , Louisa Mahaira , Dimitrios Niarchos
Blood, 2003, 101 (9), pp.3444-3450. ⟨10.1182/blood-2002-05-1501⟩
Journal articles hal-04040069v1

Non genomic regulation of TRPM8: From thermosensation to cancer

Dimitra Gkika
Biophysical Society 66th Annual Meeting, Feb 2022, San Francisco (CA, USA), United States. pp.101a, ⟨10.1016/j.bpj.2021.11.2206⟩
Conference papers hal-04503223v1