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Elisabeth Elass-Rochard

34
Documents

Présentation

**Pr Elass-Rochard Elisabeth (55 years old, born February 1965).** **Academic qualification and professional experience** -2005-present: Professor of biochemistry (CNU 64), UGSF-FST- Univ. Lille. Team “Structural Glycobiology of host-pathogen interactions”(directed by Dr Y. Guerardel DR CNRS) from 2008 to 2019 and associated actually to team “Chemoglycobiology” (Pr Biot C, UGSF). -2000: HDR (habilitation to supervise research) “La lactoferrine dans le cancer et l’inflammation” (director : Dr Legrand D). UGSF-USTL -1993-2005: Assistant professor (CNU 64) in the team of Dr J. Mazurier (DR CNRS)/ Pr Spik “Regulation of the inflammatory response and cancer by glycoconjugates”. UGSF-USTL -1992-1993: Temporary Assistant professor (ATER), UGSF- USTL. -1991-1992: Contract “ Association pour la génèralisation et l’innovation de la recherche” (AGIR) -1989-1992:Ph.D. in Sciences of life and health. Thesis:“Etude du mécanisme d’interaction de la lactoferrine avec son récepteur membranaire et de sa destinée dans les cellules cancéreuses de la glande mammaire." Team “Lactoferrin, cancer and inflammation” (Pr Spik G., UGSF, USTL)-Prix de la société des sciences, des arts et des lettres. **Scientific activity:** Ø 2016-2019: Alteration of macrophage glycosylation during mycobacterial infection and cell differentiation, through complementary approaches. Interaction of mycobacterial lectin with macrophages. Ø 2003-2016: Host-pathogen interaction and relationship structure-function of mycobacterial glycoconjugates. Ø 1995-2002: Regulation by lactoferrin of LPS-induced inflammatory process in macrophages. ***Mot clés***: Biochemistry. Glycobiology. Glycosylation of host (macrophage) and mycobacteria. Mycobacterial glycolipids: structure and immunomodulation During many years,Pr Elass-Rochard Elisabeth has studied, with Dr Legrand D. (DR CNRS), the ability of lactoferrin, a glycoprotein present in neutrophils, to regulate the inflammatory processes induced by lipopolysaccharides (LPS), by analyzing its interaction with LPS and the pattern recognition receptors of immunity *(team “Regulation of Cancer and Inflammation by glycoconjugates “, directed by Dr Mazurier)*. In 2008, she joined the *team of Dr Guerardel* Y (DR CNRS, UGSF) which is internationally recognized for its expertise on the structural analysis of glycans and polysaccharides. Thus, her research focused on the immunomodulatory properties induced by mycobacterial glycolipids on macrophages.The results have highlighted differences in the biological activity of these glycoconjugates, related to subtle structural characteristics. From 4 years ago, she has investigated with these collaborators, the changes glycosylation during monocyte/macrophage differentiation, through complementary approaches available in UGSF. Furthermore, an alteration of *N*-glycan profiling of human macrophages has been demonstrated, after infection by *M. bovis* BCG. **45 scientific publications and 2 chapters in books.** 30 international communications**.** **Thesis (co)supervisor:** Delannoy Clément 2017 (Pr Elass E), Rombouts Yoann 2010 (Elass E/Guerardel Y), Baveye-Descamps Sophie 2000 (Elass E/Legrand D). **Teaching director** (coDE 2007-2010 + 2016-2017): for “licence Sciences de la Vie- parcours biochimie” (from S4 to S6)- FST-Univ.Lille.

Publications

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Mycobacterium bovis BCG infection alters the macrophage N -glycome

Clément Delannoy , Chin Huang , Bernadette Coddeville , Jian-You Chen , Dounia Mouajjah
Molecular Omics, 2020, 16 (4), pp.345-354. ⟨10.1039/c9mo00173e⟩
Article dans une revue hal-03089946v1

Structure and biological activities of a hexosamine-rich cell wall polysaccharide isolated from the probiotic Lactobacillus farciminis

Emmanuel Maes , Irina Sadovskaya , Mathilde Lévêque , Elisabeth Elass-Rochard , Bruno Payré
Glycoconjugate Journal, 2019, 36 (1), pp.39-55. ⟨10.1007/s10719-018-09854-y⟩
Article dans une revue hal-02371915v1

Glycosylation Changes Triggered by the Differentiation of Monocytic THP-1 Cell Line into Macrophages

Clément Delannoy , Yoann Rombouts , Sophie Groux-Degroote , Stephanie Holst , Bernadette Coddeville
Journal of Proteome Research, 2016, 16 (1), pp.156 - 169. ⟨10.1021/acs.jproteome.6b00161⟩
Article dans une revue hal-01931172v1

Delta-lactoferrin induces cell death via the mitochondrial death signaling pathway by upregulating bax expression

Stephan Hardivillé , Adelma Escobar-Ramirez , Soccoro Pina-Canceco , Elisabeth Elass-Rochard , Annick Pierce
Biometals. An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine, 2014, Biometals. An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine, 27 (5), pp.875-889. ⟨10.1007/s10534-014-9744-5⟩
Article dans une revue hal-03220594v1

Glycosylphosphatidylinositols of Toxoplasma gondii induce matrix metalloproteinase-9 production and degradation of galectin-3

Sebastian Niehus , Elisabeth Elass , Bernadette Coddeville , Yann Guerardel , Ralph T Schwarz
Immunobiology, 2012, 217 (1), pp.61-64. ⟨10.1016/j.imbio.2011.08.001⟩
Article dans une revue hal-02646882v1
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Fatty acyl chains of Mycobacterium marinum lipooligosaccharides: Structure, localization and acylation by PapA4 (MMAR-2343) protein

Yoann Rombouts , Laeticia Alibaud , S. Carrere-Kremer , Emmanuel Maes , Caroline Tokarski
Journal of Biological Chemistry, 2011, 286 (38), pp.33678-33688. ⟨10.1074/jbc.M111.273920⟩
Article dans une revue hal-00641803v1

Interaction between DMBT1 and galectin 3 is modulated by the structure of the oligosaccharides carried by DMBT1

Yannick Rossez , Bernadette Coddeville , Elisabeth Elass , J.-F. Quinchon , Olivier Vidal
Biochimie, 2011, 93 (3), pp.593-603. ⟨10.1016/j.biochi.2010.12.002⟩
Article dans une revue hal-00641761v1

Non-acylated Mycobacterium bovis glycoprotein MPB83 binds to TLR1/2 and stimulates production of matrix metalloproteinase 9

M. A. Chambers , A. O. Whelan , R. Spallek , M. Singh , Bernadette Coddeville
Biochemical and Biophysical Research Communications, 2010, 400 (3), pp.403-408. ⟨10.1016/j.bbrc.2010.08.085⟩
Article dans une revue hal-00641709v1

Structural analysis of an unusual bioactive N-acylated lipo-oligosaccharide LOS-IV in Mycobacterium marinum

Yoann Rombouts , Elisabeth Elass , Christophe Biot , Emmanuel Maes , Bernadette Coddeville
Journal of the American Chemical Society, 2010, 132 (45), pp.16073-84. ⟨10.1021/ja105807s⟩
Article dans une revue hal-00641528v1

Discrimination and evaluation of lactoferrin and delta-lactoferrin gene expression levels in cancer cells and under inflammatory stimuli using TaqMan real-time PCR

Esthelle Hoedt , Stephane Hardiville , Cristophe Mariller , Elisabeth Elass , J.-P. Perraudin
BioMetals, 2010, 23 (3), pp.441-452. ⟨10.1007/s10534-010-9305-5⟩
Article dans une revue hal-00641625v1
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Binding of Toxoplasma gondii glycosylphosphatidylinositols to galectin-3 is required for their recognition by macrophages

Françoise Debierre-Grockiego , Sebastian Niehus , Bernadette Coddeville , Elisabeth Elass , F. Poirier
Journal of Biological Chemistry, 2010, 285 (43), pp.32744-32750. ⟨10.1074/jbc.M110.137588⟩
Article dans une revue hal-00641695v1
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Mycobacterium marinum lipooligosaccharides are unique caryophyllose-containing cell wall glycolipids that inhibit tumor necrosis factor-alpha secretion in macrophages.

Yoann Rombouts , Adeline Burguière , Emmanuel Maes , Bernadette Coddeville , Elisabeth Elass
Journal of Biological Chemistry, 2009, 284 (31), pp.20975-88. ⟨10.1074/jbc.M109.011429⟩
Article dans une revue hal-00458842v1

Lactoferrin structure and functions.

Dominique Legrand , Annick Pierce , Elisabeth Elass , Mathieu Carpentier , Christophe Mariller
Advances in Experimental Medicine and Biology, 2008, 606, pp.163-94
Article dans une revue hal-00222037v1

Mycobacterial lipomannan induces MAP kinase phosphatase-1 expression in macrophages.

Elisabeth Elass , Bernadette Coddeville , Laurent Kremer , Marlène Mortuaire , Joël Mazurier
FEBS Letters, 2008, 582 (3), pp.445-450. ⟨10.1016/j.febslet.2008.01.007⟩
Article dans une revue hal-00222040v1

Identification by surface plasmon resonance of the mycobacterial lipomannan and lipoarabinomannan domains involved in binding to CD14 and LPS-binding protein.

Elisabeth Elass , Bernadette Coddeville , Yann Guerardel , Laurent Kremer , Emmanuel Maes
FEBS Letters, 2007, 581 (7), pp.1383-90. ⟨10.1016/j.febslet.2007.02.056⟩
Article dans une revue hal-00149417v1

Interactions of lactoferrin with cells involved in immune function.

Dominique Legrand , Elisabeth Elass , Mathieu Carpentier , Joël Mazurier
Biochemistry and Cell Biology, 2006, 84 (3), pp.282-90. ⟨10.1139/o06-045⟩
Article dans une revue hal-00167205v1

Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism.

Elisabeth Elass , Laetitia Aubry , Maryse Masson , Denys Agnès , Yann Guérardel
Infection and Immunity, 2005, 73, pp.7064-7068
Article dans une revue hal-00087033v1

Lactoferrin: a modulator of immune and inflammatory responses.

Dominique Legrand , Elisabeth Elass , Mathieu Carpentier , Joël Mazurier
Cellular and Molecular Life Sciences, 2005, 62 (22), pp.2549-59. ⟨10.1007/s00018-005-5370-2⟩
Article dans une revue hal-00087207v1

Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism.

Elisabeth Elass , Laeticia Aubry , Maryse Masson , Agnés Denys , Yann Guerardel
Infection and Immunity, 2005, 73 (10), pp.7064-8. ⟨10.1128/IAI.73.10.7064-7068.2005⟩
Article dans une revue hal-00087166v1

Lactoferrin and host defence: an overview of its immuno-modulating and anti-inflammatory properties.

Dominique Legrand , Elisabeth Elass , Annick Pierce , Joël Mazurier
BioMetals, 2004, 17 (3), pp.225-9
Article dans une revue hal-00167240v1

Surface nucleolin participates in both the binding and endocytosis of lactoferrin in target cells.

Dominique Legrand , Keveen Vigié , Elias A Said , Elisabeth Elass , Maryse Masson
European Journal of Biochemistry, 2004, 271 (2), pp.303-17
Article dans une revue hal-00104916v1

Lipomannans, but not lipoarabinomannans, purified from Mycobacterium chelonae and Mycobacterium kansasii induce TNF-alpha and IL-8 secretion by a CD14-toll-like receptor 2-dependent mechanism.

Cecile Vignal , Yann Guerardel , Laurent Kremer , Maryse Masson , Dominique Legrand
Journal of Immunology, 2003, 171 (4), pp.2014-23
Article dans une revue hal-00149429v1

Lactoferrin inhibits the lipopolysaccharide-induced expression and proteoglycan-binding ability of interleukin-8 in human endothelial cells.

Elisabeth Elass , Maryse Masson , Joël Mazurier , Dominique Legrand
Infection and Immunity, 2002, 70 (4), pp.1860-6
Article dans une revue hal-00149471v1

Human lactoferrin interacts with soluble CD14 and inhibits expression of endothelial adhesion molecules, E-selectin and ICAM-1, induced by the CD14-lipopolysaccharide complex.

Sophie Baveye , Elisabeth Elass , Dave G. Fernig , Christophe Blanquart , Joël Mazurier
Infection and Immunity, 2000, 68 (12), pp.6519-25
Article dans une revue hal-00149466v1

Lactoferrin inhibits the binding of lipopolysaccharides to L-selectin and subsequent production of reactive oxygen species by neutrophils.

Sophie Baveye , Elisabeth Elass , Joël Mazurier , Dominique Legrand
FEBS Letters, 2000, 469 (1), pp.5-8
Article dans une revue hal-00149464v1

Lactoferrin: a multifunctional glycoprotein involved in the modulation of the inflammatory process.

Sophie Baveye , Elisabeth Elass , Joël Mazurier , Geneviève Spik , Dominique Legrand
Clinical Chemistry and Laboratory Medicine, 1999, 37 (3), pp.281-6
Article dans une revue hal-00149458v1

Role of heparan sulphate proteoglycans in the regulation of human lactoferrin binding and activity in the MDA-MB-231 breast cancer cell line.

E. Damiens , I. El Yazidi , Joël Mazurier , E. Elass-Rochard , I. Duthille
European Journal of Cell Biology, 1998, 77 (4), pp.344-51
Article dans une revue hal-00149457v1

Characterization of two kinds of lactotransferrin (lactoferrin) receptors on different target cells.

G. Spik , Delphine Legrand , B. Leveugle , J. Mazurier , T. Mikogami
Advances in Experimental Medicine and Biology, 1994, 357, pp.13-9
Article dans une revue hal-00484471v1

Study on the binding of lactotransferrin (lactoferrin) to human PHA-activated lymphocytes and non-activated platelets. Localisation and description of the receptor-binding site.

J. Mazurier , Delphine Legrand , B. Leveugle , E. Rochard , J. Montreuil
Advances in Experimental Medicine and Biology, 1994, 357, pp.111-9
Article dans une revue hal-00484472v1

Molecular interactions between human lactotransferrin and the phytohemagglutinin-activated human lymphocyte lactotransferrin receptor lie in two loop-containing regions of the N-terminal domain I of human lactotransferrin.

Delphine Legrand , J. Mazurier , A. Elass , E. Rochard , G. Vergoten
Biochemistry, 1992, 31 (38), pp.9243-51
Article dans une revue hal-00484422v1

Inhibition of the specific binding of human lactotransferrin to human peripheral-blood phytohaemagglutinin-stimulated lymphocytes by fluorescein labelling and location of the binding site.

Delphine Legrand , J. Mazurier , P. Maes , E. Rochard , J. Montreuil
Biochemical Journal, 1991, 276 ( Pt 3), pp.733-8
Article dans une revue hal-00484424v1

The N-terminal domain I of human lactotransferrin binds specifically to phytohemagglutinin-stimulated peripheral blood human lymphocyte receptors.

E. Rochard , Delphine Legrand , J. Mazurier , J. Montreuil , G. Spik
FEBS Letters, 1989, 255 (1), pp.201-4
Article dans une revue hal-00484416v1

Lactoferrin structure and functions

Dominique Legrand , Annick Pierce , Elisabeth Elass , Mathieu Carpentier , Christophe Mariller
Advances in Experimental Medicine and Biology Vol. 606, Bösze, pp.163-194, 2008, ⟨10.1007/978-0-387-74087-4-6⟩
Chapitre d'ouvrage hal-00642033v1