Emmanuel Brouillet

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Publications

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Loss of the neuronal kinase DCLK3 leads to anxiety-like behaviour and memory deficits

Lucie de Longprez , Marie-Claude Gaillard , Charles Decraene , Jean-Baptiste Perot , Celine Keime et al.
Brain - A Journal of Neurology , 2025, ⟨10.1093/brain/awaf042⟩
Article dans une revue hal-04938607 v1
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Longitudinal MRI and 1H-MRS study of SCA7 mouse forebrain reveals progressive multiregional atrophy and early brain metabolite changes indicating early neuronal and glial dysfunction

Jean-Baptiste Pérot , Anna Niewiadomska-Cimicka , Emmanuel Brouillet , Yvon Trottier , Julien Flament
PLoS ONE, 2024, 19 (1), pp.e0296790. ⟨10.1371/journal.pone.0296790⟩
Article dans une revue hal-04400325 v1

Reactive astrocytes promote proteostasis in Huntington’s disease through the JAK2-STAT3 pathway

Laurene Abjean , Lucile Ben Haim , Miriam Riquelme-Perez , Pauline Gipchtein , Céline Derbois et al.
Brain - A Journal of Neurology , 2023, 146 (1), pp.149-166. ⟨10.1093/brain/awac068⟩
Article dans une revue hal-04312671 v1

Development of an AAV-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in Tau pathology

Charlotte Duwat , Pauline Léal , Audrey Vautheny , Gwennaëlle Aurégan , Charlène Joséphine et al.
Neurobiology of Disease, 2023, 181, pp.106116. ⟨10.1016/j.nbd.2023.106116⟩
Article dans une revue hal-04312700 v1

Extreme conservation of the poly-glutamine tract in huntingtin is related to neurodevelopmental functions: the “better” may become the “enemy of the good” in the course of evolution

Emmanuel Brouillet
Cell Death and Differentiation, 2022, 29 (2), pp.266-268. ⟨10.1038/s41418-021-00927-4⟩
Article dans une revue hal-04312713 v1

Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington’s disease reveals early gray and white matter alterations

Jean-Baptiste Pérot , Marina Célestine , Marco Palombo , Marc Dhenain , Sandrine Humbert et al.
Human Molecular Genetics, 2022, ⟨10.1093/hmg/ddac036⟩
Article dans une revue hal-03787296 v1

Altered activity-regulated H3K9 acetylation at TGF-beta signaling genes during egocentric memory in Huntington’s disease

Rafael Alcalá-Vida , Caroline Lotz , Baptiste Brulé , Jonathan Seguin , Charles Decraene et al.
Progress in Neurobiology, 2022, 219, pp.102363. ⟨10.1016/j.pneurobio.2022.102363⟩
Article dans une revue hal-03850389 v1

Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington’s disease reveals early gray and white matter alterations

Jean-Baptiste Pérot , Marina Célestine , Marco Palombo , Marc Dhenain , Sandrine Humbert et al.
Human Molecular Genetics, 2022, 31 (21), pp.3581-3596. ⟨10.1093/hmg/ddac036⟩
Article dans une revue hal-04312686 v1
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Precision machine learning to understand micro-RNA regulation in neurodegenerative diseases

Lucile Mégret , Cloé Mendoza , Maialen Arrieta Lobo , Emmanuel Brouillet , Thi-Thanh-Yen Nguyen et al.
Frontiers in Molecular Neuroscience, 2022, 15, pp.914830. ⟨10.3389/fnmol.2022.914830⟩
Article dans une revue hal-04312610 v1

Altered activity-regulated H3K9 acetylation at TGF-beta signaling genes during egocentric memory in Huntington's disease

Rafael Alcalá-Vida , Caroline Lotz , Baptiste Brulé , Jonathan Seguin , Charles Decraene et al.
Progress in Neurobiology, 2022, 219, pp.102363. ⟨10.1016/j.pneurobio.2022.102363⟩
Article dans une revue hal-03853139 v1
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Time-Course of Alterations in the Endocannabinoid System after Viral-Mediated Overexpression of α-Synuclein in the Rat Brain

Rachel Kelly , Alexis-Pierre Bemelmans , Charlène Joséphine , Emmanuel Brouillet , Declan P Mckernan et al.
Molecules, 2022, 27 (2), pp.507. ⟨10.3390/molecules27020507⟩
Article dans une revue (data paper) hal-04419946 v1

Altered activity-regulated H3K9 acetylation at TGF-beta signaling genes during egocentric memory in Huntington’s disease

Rafael Alcalá-Vida , Caroline Lotz , Baptiste Brulé , Jonathan Seguin , Charles Decraene et al.
Progress in Neurobiology, 2022, 219, pp.102363. ⟨10.1016/j.pneurobio.2022.102363⟩
Article dans une revue hal-04312650 v1
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Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington’s disease reveals early gray and white matter alterations

Jean-Baptiste Pérot , Marina Célestine , Marco Palombo , Marc Dhenain , Sandrine Humbert et al.
Human Molecular Genetics, 2022, 31 (21), pp.3581-3596. ⟨10.1093/hmg/ddac036⟩
Article dans une revue hal-04246453 v1
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Reactive astrocytes promote proteostasis in Huntington's disease through the JAK2-STAT3 pathway

Laurene Abjean , Lucile Ben Haim , Miriam Riquelme-Perez , Pauline Gipchtein , Céline Derbois et al.
Brain - A Journal of Neurology , 2022, ⟨10.1093/brain/awac068/6550082⟩
Article dans une revue cea-03872742 v1
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THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency

Audrey Vautheny , Charlotte Duwat , Gwennaëlle Aurégan , Charlène Joséphine , Anne-Sophie Hérard et al.
Neurobiology of Disease, 2021, 155, pp.105398. ⟨10.1016/j.nbd.2021.105398⟩
Article dans une revue inserm-03366724 v1
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Broad Influence of Mutant Ataxin-3 on the Proteome of the Adult Brain, Young Neurons, and Axons Reveals Central Molecular Processes and Biomarkers in SCA3/MJD Using Knock-In Mouse Model

Kalina Wiatr , Łukasz Marczak , Jean-Baptiste Pérot , Emmanuel Brouillet , Julien Flament et al.
Frontiers in Molecular Neuroscience, 2021, 14, ⟨10.3389/fnmol.2021.658339⟩
Article dans une revue hal-04246406 v1
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SCA7 Mouse Cerebellar Pathology Reveals Preferential Downregulation of Key Purkinje Cell-Identity Genes and Shared Disease Signature with SCA1 and SCA2

Anna Niewiadomska-Cimicka , Frédéric Doussau , Jean-Baptiste Perot , Michel Roux , Celine Keime et al.
Journal of Neuroscience, 2021, 41 (22), pp.4910-4936. ⟨10.1523/JNEUROSCI.1882-20.2021⟩
Article dans une revue hal-03378998 v1
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Complete spatial characterisation of N-glycosylation upon striatal neuroinflammation in the rodent brain

Ana Lúcia Rebelo , Francesco Gubinelli , Pauline Roost , Caroline Jan , Emmanuel Brouillet et al.
Journal of Neuroinflammation, 2021, 18 (1), pp.116. ⟨10.1186/s12974-021-02163-6⟩
Article dans une revue cea-04470933 v1
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Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state

Anastasie Maté de Gérando , Marie D’orange , Emma Augustin , Charlène Joséphine , Gwénaelle Aurégan et al.
Brain - A Journal of Neurology , 2021, 12 (4), pp.1167-1182. ⟨10.1093/brain/awab011⟩
Article dans une revue inserm-03385148 v1
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The Small Molecule Alpha-Synuclein Aggregator, FN075, Enhances Alpha-Synuclein Pathology in Subclinical AAV Rat Models

Rachel Kelly , Andrew G Cairns , Jörgen Ådén , Fredrik Almqvist , Alexis-Pierre Bemelmans et al.
Biomolecules, 2021, 11 (11), pp.1685. ⟨10.3390/biom11111685⟩
Article dans une revue hal-04444836 v1

The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo

Noémie Cresto , Camille Gardier , Marie-Claude Gaillard , Francesco Gubinelli , Pauline Roost et al.
International Journal of Molecular Sciences, 2021, 22 (13), pp.6760. ⟨10.3390/ijms22136760⟩
Article dans une revue hal-03452142 v1

The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo

Noémie Cresto , Marie-Claude Gaillard , Camille Gardier , Francesco Gubinelli , Elsa Diguet et al.
Neurobiology of Disease, 2020, 134, pp. 104614. ⟨10.1016/j.nbd.2019.104614⟩
Article dans une revue hal-04476988 v1
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Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease.

Océane Guillemaud , Kelly Ceyzériat , Thomas Saint-Georges , Karine Cambon , Fanny Petit et al.
Neurobiology of Aging, 2020, 90, pp.135-146. ⟨10.1016/j.neurobiolaging.2020.02.010⟩
Article dans une revue cea-03023752 v1
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The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo

Noémie Cresto , Marie-Claude Gaillard , Camille Gardier , Francesco Gubinelli , Elsa Diguet et al.
Neurobiology of Disease, 2020, 134, pp.104614. ⟨10.1016/j.nbd.2019.104614⟩
Article dans une revue hal-03043360 v1
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Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease

Juliette Le Douce , Marianne Maugard , Julien Veran , Marco Matos , Pierrick Jégo et al.
Cell Metabolism, 2020, 31 (3), pp.503-517.e8. ⟨10.1016/j.cmet.2020.02.004⟩
Article dans une revue hal-02989009 v2
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Iatrogenic transmission of Alzheimer's disease: Evidence based on experimental inoculation of Alzheimer's brains into a primate

Marc Dhenain , Suzanne Lam , Charlotte Gary , Anne‐sophie Herard , James Koch et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2020, 16 (S2), ⟨10.1002/alz.042957⟩
Article dans une revue hal-03453400 v1
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Complementarity of gluCEST and $^1$H‐MRS for the study of mouse models of Huntington's disease

Jérémy Pépin , Lucie de Longprez , Fabrice Trovero , Emmanuel Brouillet , Julien Valette et al.
NMR in Biomedicine, 2020, 33 (7), pp.e4301. ⟨10.1002/nbm.4301⟩
Article dans une revue hal-03043297 v1
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Encephalopathy induced by Alzheimer brain inoculation in a non-human primate

Charlotte Gary , Suzanne Lam , Anne-Sophie Herard , James E Koch , Fanny Petit et al.
Acta Neuropathologica Communications, 2019, 7 (1), ⟨10.1186/s40478-019-0771-x⟩
Article dans une revue hal-02391937 v1
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What is gained or ‘lost in translation’ in Huntington’s disease

Emmanuel Brouillet , Karine Merienne
Brain - A Journal of Neurology , 2019, 142 (10), pp.2900-2902. ⟨10.1093/brain/awz274⟩
Article dans une revue hal-03058364 v1
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Diffusion-weighted magnetic resonance spectroscopy enables cell-specific monitoring of astrocyte reactivity $in\ vivo$

Clémence Ligneul , Marco Palombo , Edwin Hernández-Garzón , Maria-Angeles Carrillo-de Sauvage , Julien Flament et al.
NeuroImage, 2019, 191, pp.457-469. ⟨10.1016/j.neuroimage.2019.02.046⟩
Article dans une revue cea-02155405 v1
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Optogenetic Tractography for anatomo-functional characterization of cortico-subcortical neural circuits in non-human primates

S Senova , C Poupon , J Dauguet , H J Stewart , G P Dugué et al.
Scientific Reports, 2018, 8 (1), pp.3362. ⟨10.1038/s41598-018-21486-8⟩
Article dans une revue hal-04474162 v1
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The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin

Laurie Galvan , Laetitia Francelle , Marie-Claude Gaillard , Lucie de Longprez , Maria-Angeles Carrillo-de Sauvage et al.
Brain - A Journal of Neurology , 2018, 141 (5), pp.1434-1454. ⟨10.1093/brain/awy057⟩
Article dans une revue hal-02074093 v1
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Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

Kelly Ceyzériat , Lucile Ben Haim , Audrey Denizot , Dylan Pommier , Marco Matos et al.
Acta Neuropathologica Communications, 2018, 6 (1), pp.1047. ⟨10.1186/s40478-018-0606-1⟩
Article dans une revue hal-02074082 v1
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Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat

Marie D’orange , Gwenaëlle Auregan , Dimitri Cheramy , Mylène Gaudin-Guérif , Sarah Lieger et al.
Brain - A Journal of Neurology , 2018, 141 (2), pp.535-549. ⟨10.1093/brain/awx342⟩
Article dans une revue cea-02074052 v1

The unlikely partnership between LRRK 2 and α‐synuclein in Parkinson's disease

Noémie Cresto , Camille Gardier , Francesco Gubinelli , Marie‐claude Gaillard , Géraldine Liot et al.
European Journal of Neuroscience, 2018, 49 (3), pp.339-363. ⟨10.1111/ejn.14182⟩
Article dans une revue hal-04476987 v1

Energy defects in Huntington's disease: Why “in vivo” evidence matters

Géraldine Liot , Julien Valette , Jérémy Pépin , Julien Flament , Emmanuel Brouillet
Biochemical and Biophysical Research Communications, 2017, 483, pp.1084 - 1095. ⟨10.1016/j.bbrc.2016.09.065⟩
Article dans une revue cea-01752431 v1

Contribution of Neuroepigenetics to Huntington’s Disease

Laetitia Francelle , Caroline Lotz , Tiago Outeiro , Emmanuel Brouillet , Karine Merienne
Frontiers in Human Neuroscience, 2017, 11, ⟨10.3389/fnhum.2017.00017⟩
Article dans une revue cea-01751739 v1

Contribution of Neuroepigenetics to Huntington’s Disease

Laetitia Francelle , Caroline Lotz , Tiago Outeiro , Emmanuel Brouillet , Karine Merienne
Frontiers in Human Neuroscience, 2017, 11, ⟨10.3389/fnhum.2017.00017⟩
Article dans une revue hal-03060269 v1
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Altered enhancer transcription underlies Huntington’s disease striatal transcriptional signature

Stéphanie Le Gras , Céline Keime , Anne Anthony , Caroline Lotz , Lucie de Longprez et al.
Scientific Reports, 2017, 7 (Article number: 42875), ⟨10.1038/srep42875⟩
Article dans une revue cea-01751880 v1
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Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin

Jocelyne Caboche , Galan-Rodriguez Beatriz , Martin Elodie , Emmanuel ; Déglon , Betuing Sandrine et al.
European Journal of Neuroscience, 2017, 45 (1), pp.198-206. ⟨10.1111/ejn.13415⟩
Article dans une revue hal-03365878 v1

Energy defects in Huntington's disease: Why “in vivo” evidence matters

Géraldine Liot , Julien Valette , Jérémy Pépin , Julien Flament , Emmanuel Brouillet
Biochemical and Biophysical Research Communications, 2017, 483 (4), pp.1084-1095. ⟨10.1016/j.bbrc.2016.09.065⟩
Article dans une revue hal-04476989 v1
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Imaging and spectroscopic approaches to probe brain energy metabolism dysregulation in neurodegenerative diseases

Gilles Bonvento , Julien Valette , Julien Flament , Fanny Mochel , Emmanuel Brouillet
Journal of Cerebral Blood Flow and Metabolism, 2017, 37 (6), pp.1927-1943. ⟨10.1177/0271678X17697989⟩
Article dans une revue hal-01539753 v1

In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease

Jérémy Pépin , Laetitia Francelle , Maria-Angeles Carrillo-de Sauvage , Lucie de Longprez , Pauline Gipchtein et al.
NeuroImage, 2016, 139, pp.53-64. ⟨10.1016/j.neuroimage.2016.06.023⟩
Article dans une revue cea-02397809 v1
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New paradigm to assess brain cell morphology by diffusion-weighted MR spectroscopy in vivo

Marco Palombo , Clémence Ligneul , Chloé Najac , Juliette Le Douce , Julien Flament et al.
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (24), pp.6671-6676. ⟨10.1073/pnas.1504327113⟩
Article dans une revue cea-02155309 v1
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Evidence for a “metabolically inactive” inorganic phosphate pool in adenosine triphosphate synthase reaction using localized 31P saturation transfer magnetic resonance spectroscopy in the rat brain at 11.7 T

Brice Tiret , Emmanuel Brouillet , Julien Valette
Journal of Cerebral Blood Flow and Metabolism, 2016, 36 (9), pp.1513-1518. ⟨10.1177/0271678X16657095⟩
Article dans une revue cea-02155315 v1

Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease

Anne Rocher , Paolo Gubellini , Nicolas Merienne , Lydie Boussicault , Fanny Petit et al.
Neurobiology of Disease, 2016, 86, pp.131-139. ⟨10.1016/j.nbd.2015.10.016⟩
Article dans une revue hal-03584029 v1
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Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin

Beatriz Galan-Rodriguez , Elodie Martin , Emmanuel Brouillet , Nicole Déglon , Sandrine Betuing et al.
European Journal of Neuroscience, 2016, pp.198-206 ⟨10.1111/ejn.13415⟩
Article dans une revue hal-01396567 v1
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The Neuroprotective Agent CNTF Decreases Neuronal Metabolites in the Rat Striatum: An $in\ Vivo$ Multimodal Magnetic Resonance Imaging Study

Maria-Angeles Carrillo-de Sauvage , Julien Flament , Yann Bramoullé , Lucile Ben Haim , Martine Guillermier et al.
Journal of Cerebral Blood Flow and Metabolism, 2015, 35 (6), pp.917-921. ⟨10.1038/jcbfm.2015.48⟩
Article dans une revue cea-02168367 v1
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Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition

Maggie Roy , Cécile Cardoso , Olène Dorieux , Carole Malgorn , Stéphane Epelbaum et al.
Neurobiology of Aging, 2015, 36 (1), pp.149-156. ⟨10.1016/j.neurobiolaging.2014.07.017⟩
Article dans une revue mnhn-02291873 v1
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The striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo

Laetitia Francelle , Laurie Galvan , Marie-Claude Gaillard , Fanny Petit , Benoit Bernay et al.
Neurobiology of Aging, 2015, 36 (3), pp.1601.e7-1601.e16. ⟨10.1016/j.neurobiolaging.2014.11.014⟩
Article dans une revue hal-02459770 v1

Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo.

Laetitia Francelle , Laurie Galvan , Marie-Claude Gaillard , Fanny Petit , Benoît Bernay et al.
Neurobiology of Aging, 2015, pp.1601.e7-16. ⟨10.1016/j.neurobiolaging.2014.11.014⟩
Article dans une revue hal-01465910 v1

Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions

Lydie Boussicault , Anne-Sophie Herard , Noel Calingasan , Fanny Petit , Carole Malgorn et al.
Journal of Cerebral Blood Flow and Metabolism, 2014, 34 (9), pp.1500-1510. ⟨10.1038/jcbfm.2014.110⟩
Article dans une revue hal-01545792 v1

SET translocation is associated with increase in caspase cleaved amyloid precursor protein in CA1 of Alzheimer and Down syndrome patients.

Patricia Facchinetti , Emilie Dorard , Vincent Contremoulins , Marie-Claude Gaillard , Nicole Déglon et al.
Neurobiol Aging, 2014, 35 (5), pp.958-68. ⟨10.1016/j.neurobiolaging.2013.08.039⟩
Article dans une revue hal-00946234 v1
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Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease

Laetitia Francelle , Laurie Galvan , Emmanuel Brouillet
Frontiers in Cellular Neuroscience, 2014, ⟨10.3389/fncel.2014.00295⟩
Article dans une revue hal-02459873 v1
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IRC-082451, a novel multitargeting molecule, reduces L-DOPA-induced dyskinesias in MPTP Parkinsonian primates.

Romina Aron Badin , Brigitte Spinnewyn , Marie-Claude Gaillard , Caroline Jan , Carole Malgorn et al.
PLoS ONE, 2013, 8 (1), pp.e52680. ⟨10.1371/journal.pone.0052680⟩
Article dans une revue inserm-00857944 v1

Ectosomes: a new mechanism for non-exosomal secretion of tau protein.

Simon Dujardin , Séverine Bégard , Raphaëlle Caillierez , Cédrick Lachaud , Lucie Delattre et al.
PLoS ONE, 2013, 9 (6), pp.e100760. ⟨10.1371/journal.pone.0100760⟩
Article dans une revue hal-01181185 v1

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

Maria Damiano , Elsa Diguet , Carole Malgorn , Marilena d'Aurelio , Laurie Galvan et al.
Human Molecular Genetics, 2013, 22 (19), pp.3869-3882. ⟨10.1093/hmg/ddt242⟩
Article dans une revue hal-02459752 v1

Capucin does not modify the toxicity of a mutant Huntingtin fragment in vivo

Laurie Galvan , Nad'A Lepejová , Marie-Claude Gaillard , Carole Malgorn , Martine Guillermier et al.
Neurobiology of Aging, 2012, 33 (8), pp.1845.e5-1845.e6. ⟨10.1016/j.neurobiolaging.2012.01.009⟩
Article dans une revue istex hal-02459764 v1

The Nrf2 pathway as a potential therapeutic target for Huntington disease. A commentary on “Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington disease”

Carole Escartin , Emmanuel Brouillet
Free Radical Biology and Medicine, 2010, 49 (2), pp.144-146. ⟨10.1016/j.freeradbiomed.2010.04.009⟩
Article dans une revue istex cea-02168439 v1

Mitochondria in Huntington's disease

Maria Damiano , Laurie Galvan , Nicole Déglon , Emmanuel Brouillet
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2010, 1802 (1), pp.52-61. ⟨10.1016/j.bbadis.2009.07.012⟩
Article dans une revue hal-02459756 v1
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Mitochondria in Huntington's disease

Maria Damiano , Laurie Galvan , Nicole Déglon , Emmanuel Brouillet
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2009, 1802 (1), pp.52. ⟨10.1016/j.bbadis.2009.07.012⟩
Article dans une revue hal-00543005 v1
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Normal Aging Modulates the Neurotoxicity of Mutant Huntingtin

Elsa Diguet , Fanny Petit , Carole Escartin , Karine Cambon , Nicolas Bizat et al.
PLoS ONE, 2009, 4 (2), pp.e4637. ⟨10.1371/journal.pone.0004637⟩
Article dans une revue cea-02290598 v1

Discovering new bioactive neuropeptides in the striatum secretome using in vivo microdialysis and versatile proteomics.

Benoît Bernay , Marie-Claude Gaillard , Vilém Guryca , Anouk Emadali , Lauriane Kuhn et al.
Molecular and Cellular Proteomics, 2009, 8 (5), pp.946-58. ⟨10.1074/mcp.M800501-MCP200⟩
Article dans une revue inserm-00410894 v1

Dopamine Gene Therapy for Parkinson’s Disease in a Nonhuman Primate Without Associated Dyskinesia

Béchir Jarraya , Sabrina Boulet , G. Scott Ralph , Caroline Jan , Gilles Bonvento et al.
Science Translational Medicine, 2009, 1 (2), ⟨10.1126/scitranslmed.3000130⟩
Article dans une revue hal-03978589 v1

Quantitative gene expression profiling of mouse brain regions reveals differential transcripts conserved in human and affected in disease models.

Camille Brochier , Marie-Claude Gaillard , Elsa Diguet , Nicolas Caudy , Carole Dossat et al.
Physiological Genomics, 2008, 33 (2), pp.170-9. ⟨10.1152/physiolgenomics.00125.2007⟩
Article dans une revue hal-00275419 v1
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IGF-1 exacerbates the neurotoxicity of the mitochondrial inhibitor 3NP in rats

Carole Escartin , Frédéric Boyer , Alexis-Pierre Bemelmans , Philippe Hantraye , Emmanuel Brouillet
Neuroscience Letters, 2007, 425 (3), pp.167-172. ⟨10.1016/j.neulet.2007.08.031⟩
Article dans une revue cea-02290618 v1
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Activation of Astrocytes by CNTF Induces Metabolic Plasticity and Increases Resistance to Metabolic Insults

Carole Escartin , Karin Pierre , Angélique Colin , Emmanuel Brouillet , Thierry Delzescaux et al.
Journal of Neuroscience, 2007, 27 (27), pp.7094-7104. ⟨10.1523/JNEUROSCI.0174-07.2007⟩
Article dans une revue cea-02290623 v1

Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo.

Delphine Charvin , Emmanuel Roze , Valérie Perrin , Carole Deyts , Sandrine Betuing et al.
Neurobiology of Disease, 2007, 29 (1), pp.22-29. ⟨10.1016/j.nbd.2007.07.028⟩
Article dans une revue istex hal-00181915 v1

Brain mitochondrial defects amplify intracellular [Ca2+] rise and neurodegeneration but not Ca2+ entry during NMDA receptor activation

Carine Jacquard , Yael Trioulier , François Cosker , Carole Escartin , Nicolas Bizat et al.
FASEB Journal, 2006, 20(7), pp.1021-1023. ⟨10.1096/fj.05-5085fje⟩
Article dans une revue hal-00103460 v1

CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity

Margarita Arango , Sébastien Holbert , Dania Zala , Emmanuel Brouillet , James Pearson et al.
Journal of Neuroscience, 2006, 26 (17), pp.4649 - 4659. ⟨10.1523/JNEUROSCI.5409-05.2006⟩
Article dans une revue hal-02666883 v1

Insulin growth factor-1 protects against excitotoxicity in the rat striatum

Carole Escartin , Frédéric Boyer , Alexis-Pierre Bemelmans , Philippe Hantraye , Emmanuel Brouillet
NeuroReport, 2004, 15 (14), pp.2251-2254. ⟨10.1097/00001756-200410050-00022⟩
Article dans une revue cea-02290615 v1
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Calpain is a major cell death effector in selective striatal degeneration induced $in\ vivo$ by 3-nitropropionate: implications for Huntington's disease.

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