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Loss of the neuronal kinase DCLK3 leads to anxiety-like behaviour and memory deficits
Lucie de Longprez
,
Marie-Claude Gaillard
,
Charles Decraene
,
Jean-Baptiste Perot
,
Celine Keime
et al.
Article dans une revue
hal-04938607
v1
|
|
Longitudinal MRI and 1H-MRS study of SCA7 mouse forebrain reveals progressive multiregional atrophy and early brain metabolite changes indicating early neuronal and glial dysfunction
Jean-Baptiste Pérot
,
Anna Niewiadomska-Cimicka
,
Emmanuel Brouillet
,
Yvon Trottier
,
Julien Flament
Article dans une revue
hal-04400325
v1
|
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Reactive astrocytes promote proteostasis in Huntington’s disease through the JAK2-STAT3 pathway
Laurene Abjean
,
Lucile Ben Haim
,
Miriam Riquelme-Perez
,
Pauline Gipchtein
,
Céline Derbois
et al.
Article dans une revue
hal-04312671
v1
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Development of an AAV-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in Tau pathology
Charlotte Duwat
,
Pauline Léal
,
Audrey Vautheny
,
Gwennaëlle Aurégan
,
Charlène Joséphine
et al.
Article dans une revue
hal-04312700
v1
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Extreme conservation of the poly-glutamine tract in huntingtin is related to neurodevelopmental functions: the “better” may become the “enemy of the good” in the course of evolution
Emmanuel Brouillet
Article dans une revue
hal-04312713
v1
|
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Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington’s disease reveals early gray and white matter alterations
Jean-Baptiste Pérot
,
Marina Célestine
,
Marco Palombo
,
Marc Dhenain
,
Sandrine Humbert
et al.
Article dans une revue
hal-03787296
v1
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Altered activity-regulated H3K9 acetylation at TGF-beta signaling genes during egocentric memory in Huntington’s disease
Rafael Alcalá-Vida
,
Caroline Lotz
,
Baptiste Brulé
,
Jonathan Seguin
,
Charles Decraene
et al.
Article dans une revue
hal-03850389
v1
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Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington’s disease reveals early gray and white matter alterations
Jean-Baptiste Pérot
,
Marina Célestine
,
Marco Palombo
,
Marc Dhenain
,
Sandrine Humbert
et al.
Article dans une revue
hal-04312686
v1
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Precision machine learning to understand micro-RNA regulation in neurodegenerative diseases
Lucile Mégret
,
Cloé Mendoza
,
Maialen Arrieta Lobo
,
Emmanuel Brouillet
,
Thi-Thanh-Yen Nguyen
et al.
Article dans une revue
hal-04312610
v1
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Altered activity-regulated H3K9 acetylation at TGF-beta signaling genes during egocentric memory in Huntington's disease
Rafael Alcalá-Vida
,
Caroline Lotz
,
Baptiste Brulé
,
Jonathan Seguin
,
Charles Decraene
et al.
Article dans une revue
hal-03853139
v1
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Time-Course of Alterations in the Endocannabinoid System after Viral-Mediated Overexpression of α-Synuclein in the Rat Brain
Rachel Kelly
,
Alexis-Pierre Bemelmans
,
Charlène Joséphine
,
Emmanuel Brouillet
,
Declan P Mckernan
et al.
Article dans une revue
(data paper)
hal-04419946
v1
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Altered activity-regulated H3K9 acetylation at TGF-beta signaling genes during egocentric memory in Huntington’s disease
Rafael Alcalá-Vida
,
Caroline Lotz
,
Baptiste Brulé
,
Jonathan Seguin
,
Charles Decraene
et al.
Article dans une revue
hal-04312650
v1
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Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington’s disease reveals early gray and white matter alterations
Jean-Baptiste Pérot
,
Marina Célestine
,
Marco Palombo
,
Marc Dhenain
,
Sandrine Humbert
et al.
Article dans une revue
hal-04246453
v1
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Reactive astrocytes promote proteostasis in Huntington's disease through the JAK2-STAT3 pathway
Laurene Abjean
,
Lucile Ben Haim
,
Miriam Riquelme-Perez
,
Pauline Gipchtein
,
Céline Derbois
et al.
Article dans une revue
cea-03872742
v1
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THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency
Audrey Vautheny
,
Charlotte Duwat
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Gwennaëlle Aurégan
,
Charlène Joséphine
,
Anne-Sophie Hérard
et al.
Article dans une revue
inserm-03366724
v1
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Broad Influence of Mutant Ataxin-3 on the Proteome of the Adult Brain, Young Neurons, and Axons Reveals Central Molecular Processes and Biomarkers in SCA3/MJD Using Knock-In Mouse Model
Kalina Wiatr
,
Łukasz Marczak
,
Jean-Baptiste Pérot
,
Emmanuel Brouillet
,
Julien Flament
et al.
Article dans une revue
hal-04246406
v1
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SCA7 Mouse Cerebellar Pathology Reveals Preferential Downregulation of Key Purkinje Cell-Identity Genes and Shared Disease Signature with SCA1 and SCA2
Anna Niewiadomska-Cimicka
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Frédéric Doussau
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Jean-Baptiste Perot
,
Michel Roux
,
Celine Keime
et al.
Article dans une revue
hal-03378998
v1
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Complete spatial characterisation of N-glycosylation upon striatal neuroinflammation in the rodent brain
Ana Lúcia Rebelo
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Francesco Gubinelli
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Pauline Roost
,
Caroline Jan
,
Emmanuel Brouillet
et al.
Article dans une revue
cea-04470933
v1
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Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state
Anastasie Maté de Gérando
,
Marie D’orange
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Emma Augustin
,
Charlène Joséphine
,
Gwénaelle Aurégan
et al.
Article dans une revue
inserm-03385148
v1
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The Small Molecule Alpha-Synuclein Aggregator, FN075, Enhances Alpha-Synuclein Pathology in Subclinical AAV Rat Models
Rachel Kelly
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Andrew G Cairns
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Jörgen Ådén
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Fredrik Almqvist
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Alexis-Pierre Bemelmans
et al.
Article dans une revue
hal-04444836
v1
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The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo
Noémie Cresto
,
Camille Gardier
,
Marie-Claude Gaillard
,
Francesco Gubinelli
,
Pauline Roost
et al.
Article dans une revue
hal-03452142
v1
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The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo
Noémie Cresto
,
Marie-Claude Gaillard
,
Camille Gardier
,
Francesco Gubinelli
,
Elsa Diguet
et al.
Article dans une revue
hal-04476988
v1
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Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease.
Océane Guillemaud
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Kelly Ceyzériat
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Thomas Saint-Georges
,
Karine Cambon
,
Fanny Petit
et al.
Article dans une revue
cea-03023752
v1
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The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo
Noémie Cresto
,
Marie-Claude Gaillard
,
Camille Gardier
,
Francesco Gubinelli
,
Elsa Diguet
et al.
Article dans une revue
hal-03043360
v1
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Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease
Juliette Le Douce
,
Marianne Maugard
,
Julien Veran
,
Marco Matos
,
Pierrick Jégo
et al.
Article dans une revue
hal-02989009
v2
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Iatrogenic transmission of Alzheimer's disease: Evidence based on experimental inoculation of Alzheimer's brains into a primate
Marc Dhenain
,
Suzanne Lam
,
Charlotte Gary
,
Anne‐sophie Herard
,
James Koch
et al.
Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2020, 16 (S2), ⟨10.1002/alz.042957⟩
Article dans une revue
hal-03453400
v1
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Complementarity of gluCEST and $^1$H‐MRS for the study of mouse models of Huntington's disease
Jérémy Pépin
,
Lucie de Longprez
,
Fabrice Trovero
,
Emmanuel Brouillet
,
Julien Valette
et al.
Article dans une revue
hal-03043297
v1
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Encephalopathy induced by Alzheimer brain inoculation in a non-human primate
Charlotte Gary
,
Suzanne Lam
,
Anne-Sophie Herard
,
James E Koch
,
Fanny Petit
et al.
Article dans une revue
hal-02391937
v1
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What is gained or ‘lost in translation’ in Huntington’s disease
Emmanuel Brouillet
,
Karine Merienne
Article dans une revue
hal-03058364
v1
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Diffusion-weighted magnetic resonance spectroscopy enables cell-specific monitoring of astrocyte reactivity $in\ vivo$
Clémence Ligneul
,
Marco Palombo
,
Edwin Hernández-Garzón
,
Maria-Angeles Carrillo-de Sauvage
,
Julien Flament
et al.
Article dans une revue
cea-02155405
v1
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Optogenetic Tractography for anatomo-functional characterization of cortico-subcortical neural circuits in non-human primates
S Senova
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C Poupon
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J Dauguet
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H J Stewart
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G P Dugué
et al.
Article dans une revue
hal-04474162
v1
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The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin
Laurie Galvan
,
Laetitia Francelle
,
Marie-Claude Gaillard
,
Lucie de Longprez
,
Maria-Angeles Carrillo-de Sauvage
et al.
Article dans une revue
hal-02074093
v1
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Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease
Kelly Ceyzériat
,
Lucile Ben Haim
,
Audrey Denizot
,
Dylan Pommier
,
Marco Matos
et al.
Article dans une revue
hal-02074082
v1
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Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat
Marie D’orange
,
Gwenaëlle Auregan
,
Dimitri Cheramy
,
Mylène Gaudin-Guérif
,
Sarah Lieger
et al.
Article dans une revue
cea-02074052
v1
|
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The unlikely partnership between LRRK 2 and α‐synuclein in Parkinson's disease
Noémie Cresto
,
Camille Gardier
,
Francesco Gubinelli
,
Marie‐claude Gaillard
,
Géraldine Liot
et al.
Article dans une revue
hal-04476987
v1
|
|
Energy defects in Huntington's disease: Why “in vivo” evidence matters
Géraldine Liot
,
Julien Valette
,
Jérémy Pépin
,
Julien Flament
,
Emmanuel Brouillet
Article dans une revue
cea-01752431
v1
|
|
Contribution of Neuroepigenetics to Huntington’s Disease
Laetitia Francelle
,
Caroline Lotz
,
Tiago Outeiro
,
Emmanuel Brouillet
,
Karine Merienne
Article dans une revue
cea-01751739
v1
|
|
Contribution of Neuroepigenetics to Huntington’s Disease
Laetitia Francelle
,
Caroline Lotz
,
Tiago Outeiro
,
Emmanuel Brouillet
,
Karine Merienne
Article dans une revue
hal-03060269
v1
|
|
Altered enhancer transcription underlies Huntington’s disease striatal transcriptional signature
Stéphanie Le Gras
,
Céline Keime
,
Anne Anthony
,
Caroline Lotz
,
Lucie de Longprez
et al.
Article dans une revue
cea-01751880
v1
|
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Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin
Jocelyne Caboche
,
Galan-Rodriguez Beatriz
,
Martin Elodie
,
Emmanuel ; Déglon
,
Betuing Sandrine
et al.
Article dans une revue
hal-03365878
v1
|
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Energy defects in Huntington's disease: Why “in vivo” evidence matters
Géraldine Liot
,
Julien Valette
,
Jérémy Pépin
,
Julien Flament
,
Emmanuel Brouillet
Article dans une revue
hal-04476989
v1
|
|
Imaging and spectroscopic approaches to probe brain energy metabolism dysregulation in neurodegenerative diseases
Gilles Bonvento
,
Julien Valette
,
Julien Flament
,
Fanny Mochel
,
Emmanuel Brouillet
Article dans une revue
hal-01539753
v1
|
|
In vivo imaging of brain glutamate defects in a knock-in mouse model of Huntington's disease
Jérémy Pépin
,
Laetitia Francelle
,
Maria-Angeles Carrillo-de Sauvage
,
Lucie de Longprez
,
Pauline Gipchtein
et al.
Article dans une revue
cea-02397809
v1
|
|
New paradigm to assess brain cell morphology by diffusion-weighted MR spectroscopy in vivo
Marco Palombo
,
Clémence Ligneul
,
Chloé Najac
,
Juliette Le Douce
,
Julien Flament
et al.
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (24), pp.6671-6676. ⟨10.1073/pnas.1504327113⟩
Article dans une revue
cea-02155309
v1
|
|
Evidence for a “metabolically inactive” inorganic phosphate pool in adenosine triphosphate synthase reaction using localized 31P saturation transfer magnetic resonance spectroscopy in the rat brain at 11.7 T
Brice Tiret
,
Emmanuel Brouillet
,
Julien Valette
Article dans une revue
cea-02155315
v1
|
|
Synaptic scaling up in medium spiny neurons of aged BACHD mice: A slow-progression model of Huntington's disease
Anne Rocher
,
Paolo Gubellini
,
Nicolas Merienne
,
Lydie Boussicault
,
Fanny Petit
et al.
Article dans une revue
hal-03584029
v1
|
|
Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin
Beatriz Galan-Rodriguez
,
Elodie Martin
,
Emmanuel Brouillet
,
Nicole Déglon
,
Sandrine Betuing
et al.
Article dans une revue
hal-01396567
v1
|
|
The Neuroprotective Agent CNTF Decreases Neuronal Metabolites in the Rat Striatum: An $in\ Vivo$ Multimodal Magnetic Resonance Imaging Study
Maria-Angeles Carrillo-de Sauvage
,
Julien Flament
,
Yann Bramoullé
,
Lucile Ben Haim
,
Martine Guillermier
et al.
Article dans une revue
cea-02168367
v1
|
|
Age-associated evolution of plasmatic amyloid in mouse lemur primates: relationship with intracellular amyloid deposition
Maggie Roy
,
Cécile Cardoso
,
Olène Dorieux
,
Carole Malgorn
,
Stéphane Epelbaum
et al.
Article dans une revue
mnhn-02291873
v1
|
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The striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo
Laetitia Francelle
,
Laurie Galvan
,
Marie-Claude Gaillard
,
Fanny Petit
,
Benoit Bernay
et al.
Article dans une revue
hal-02459770
v1
|
|
Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo.
Laetitia Francelle
,
Laurie Galvan
,
Marie-Claude Gaillard
,
Fanny Petit
,
Benoît Bernay
et al.
Article dans une revue
hal-01465910
v1
|
|
Impaired brain energy metabolism in the BACHD mouse model of Huntington's disease: critical role of astrocyte-neuron interactions
Lydie Boussicault
,
Anne-Sophie Herard
,
Noel Calingasan
,
Fanny Petit
,
Carole Malgorn
et al.
Article dans une revue
hal-01545792
v1
|
|
SET translocation is associated with increase in caspase cleaved amyloid precursor protein in CA1 of Alzheimer and Down syndrome patients.
Patricia Facchinetti
,
Emilie Dorard
,
Vincent Contremoulins
,
Marie-Claude Gaillard
,
Nicole Déglon
et al.
Article dans une revue
hal-00946234
v1
|
|
Possible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's disease
Laetitia Francelle
,
Laurie Galvan
,
Emmanuel Brouillet
Article dans une revue
hal-02459873
v1
|
|
IRC-082451, a novel multitargeting molecule, reduces L-DOPA-induced dyskinesias in MPTP Parkinsonian primates.
Romina Aron Badin
,
Brigitte Spinnewyn
,
Marie-Claude Gaillard
,
Caroline Jan
,
Carole Malgorn
et al.
Article dans une revue
inserm-00857944
v1
|
|
Ectosomes: a new mechanism for non-exosomal secretion of tau protein.
Simon Dujardin
,
Séverine Bégard
,
Raphaëlle Caillierez
,
Cédrick Lachaud
,
Lucie Delattre
et al.
Article dans une revue
hal-01181185
v1
|
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A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin
Maria Damiano
,
Elsa Diguet
,
Carole Malgorn
,
Marilena d'Aurelio
,
Laurie Galvan
et al.
Article dans une revue
hal-02459752
v1
|
|
Capucin does not modify the toxicity of a mutant Huntingtin fragment in vivo
Laurie Galvan
,
Nad'A Lepejová
,
Marie-Claude Gaillard
,
Carole Malgorn
,
Martine Guillermier
et al.
Article dans une revue
istex
hal-02459764
v1
|
|
The Nrf2 pathway as a potential therapeutic target for Huntington disease. A commentary on “Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington disease”
Carole Escartin
,
Emmanuel Brouillet
Article dans une revue
istex
cea-02168439
v1
|
|
Mitochondria in Huntington's disease
Maria Damiano
,
Laurie Galvan
,
Nicole Déglon
,
Emmanuel Brouillet
Article dans une revue
hal-02459756
v1
|
|
Mitochondria in Huntington's disease
Maria Damiano
,
Laurie Galvan
,
Nicole Déglon
,
Emmanuel Brouillet
Article dans une revue
hal-00543005
v1
|
|
Normal Aging Modulates the Neurotoxicity of Mutant Huntingtin
Elsa Diguet
,
Fanny Petit
,
Carole Escartin
,
Karine Cambon
,
Nicolas Bizat
et al.
Article dans une revue
cea-02290598
v1
|
|
Discovering new bioactive neuropeptides in the striatum secretome using in vivo microdialysis and versatile proteomics.
Benoît Bernay
,
Marie-Claude Gaillard
,
Vilém Guryca
,
Anouk Emadali
,
Lauriane Kuhn
et al.
Article dans une revue
inserm-00410894
v1
|
|
Dopamine Gene Therapy for Parkinson’s Disease in a Nonhuman Primate Without Associated Dyskinesia
Béchir Jarraya
,
Sabrina Boulet
,
G. Scott Ralph
,
Caroline Jan
,
Gilles Bonvento
et al.
Article dans une revue
hal-03978589
v1
|
|
Quantitative gene expression profiling of mouse brain regions reveals differential transcripts conserved in human and affected in disease models.
Camille Brochier
,
Marie-Claude Gaillard
,
Elsa Diguet
,
Nicolas Caudy
,
Carole Dossat
et al.
Article dans une revue
hal-00275419
v1
|
|
IGF-1 exacerbates the neurotoxicity of the mitochondrial inhibitor 3NP in rats
Carole Escartin
,
Frédéric Boyer
,
Alexis-Pierre Bemelmans
,
Philippe Hantraye
,
Emmanuel Brouillet
Article dans une revue
cea-02290618
v1
|
|
Activation of Astrocytes by CNTF Induces Metabolic Plasticity and Increases Resistance to Metabolic Insults
Carole Escartin
,
Karin Pierre
,
Angélique Colin
,
Emmanuel Brouillet
,
Thierry Delzescaux
et al.
Article dans une revue
cea-02290623
v1
|
|
Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo.
Delphine Charvin
,
Emmanuel Roze
,
Valérie Perrin
,
Carole Deyts
,
Sandrine Betuing
et al.
Article dans une revue
istex
hal-00181915
v1
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|
Brain mitochondrial defects amplify intracellular [Ca2+] rise and neurodegeneration but not Ca2+ entry during NMDA receptor activation
Carine Jacquard
,
Yael Trioulier
,
François Cosker
,
Carole Escartin
,
Nicolas Bizat
et al.
Article dans une revue
hal-00103460
v1
|
|
CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity
Margarita Arango
,
Sébastien Holbert
,
Dania Zala
,
Emmanuel Brouillet
,
James Pearson
et al.
Article dans une revue
hal-02666883
v1
|
|
Insulin growth factor-1 protects against excitotoxicity in the rat striatum
Carole Escartin
,
Frédéric Boyer
,
Alexis-Pierre Bemelmans
,
Philippe Hantraye
,
Emmanuel Brouillet
Article dans une revue
cea-02290615
v1
|
|
Calpain is a major cell death effector in selective striatal degeneration induced $in\ vivo$ by 3-nitropropionate: implications for Huntington's disease.
Nicolas Bizat
,
Jean-Michel Hermel
,
Frédéric Boyer
,
Carine Jacquard
,
Christophe Créminon
et al.
Journal of Neuroscience, 2003, 23 (12), pp.5020-30
Article dans une revue
cea-02290630
v1
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$In\ Vivo$ Calpain/Caspase Cross-talk during 3-Nitropropionic Acid-induced Striatal Degeneration
Nicolas Bizat
,
Jean-Michel Hermel
,
Sandrine Humbert
,
Carine Jacquard
,
Christophe Créminon
et al.
Article dans une revue
cea-02290633
v1
|
|
The Mitochondrial Toxin 3-Nitropropionic Acid Induces Striatal Neurodegeneration via a c-Jun N-Terminal Kinase/c-Jun Module
Marta Garcia
,
Peter Vanhoutte
,
Christiane Pagès
,
Marie-Jo Besson
,
Emmanuel Brouillet
et al.
Article dans une revue
hal-02372666
v1
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Corticostriatopallidal Neuroprotection by Adenovirus-Mediated Ciliary Neurotrophic Factor Gene Transfer in a Rat Model of Progressive Striatal Degeneration
Vincent Mittoux
,
Stephane Ouary
,
Christelle Monville
,
Fabrice Lisovoski
,
Thomas Poyot
et al.
Journal of Neuroscience, 2002, 22 (11), pp.4478-86
Article dans une revue
cea-02290628
v1
|
|
Perseverative behavior underlying attentional set-shifting deficits in rats chronically treated with the neurotoxin 3-nitropropionic acid.
Nicole El Massioui
,
Stéphane Ouary
,
Fabrice Chéruel
,
Philippe Hantraye
,
Emmanuel Brouillet
Article dans une revue
istex
hal-01467542
v1
|