Eyad ALMOUAZEN

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Présentation

Sep 2021 – Present: Principal Scientist, Drug Product Development Virbac SA, Carros, France

Lead R&D formulation unit, driving the development of biological drug products through the CMC phase.

Apply QbD principles to enhance formulation performance and ensure robust, scalable manufacturing processes for liquid and lyophilized products.

Spearhead 3 technical transfer projects, overseeing both internal and outsourced manufacturing to ensure seamless execution and compliance with regulatory standards.

Sep 2014 – Sep 2021: Associated Professor University Lyon 1

Teaching at Faculty of Pharmacy ISPB, Pharmaceutical and Cosmetic Technology Department

Research at LAGEP‐ UMR CNRS 5007 – Pharmaceutical Engineering Team

Design and development of innovative dosage forms for therapeutic applications: working on the elaboration of pharmaceutical formulations, the development of required analytical methods and the needed biological evaluations.

2012 – 2014 Temporary Assistant Professor Faculty of Pharmacy ISPB, University Lyon 1, France

Research: oral vaccine development for veterinary application

2009 – 2013 PhD student in Pharmaceutical Technology LAGEP UMR CNRS 5007 and INSERM U1028, University Lyon1, France

Thesis title: Development of polymeric nanoparticles for targeting and modulating macrophage functions. -Retinoic acid and vitamin D3 encapsulation by nanoprecipitation -Evaluation of nanoparticle uptake by macrophages in vitro and in vivo -Assessment of therapeutical potential of developed nanoparticles

Feb – July 2009 MSc Research internship LAGEP UMR CNRS 5007 and INSERM U851, University Lyon1, France

Project title: Use of nano-encapsulated haptens to improve the performance of skin sensitization non-animal test. -Elaboration of hapten loaded polymeric nanoparticle. -Test of nanoparticles on dendritic cells – T-cells co-culture.

Mar – Sep 2008 Formulation Engineer Laboratory of skin care development, L’Oreal-Paris, Chevilly-Larue, France

Project title: New formulation development for cleansing application. -Formulation and stability study of low viscosity emulsions.

Jan – Juin 2007 R&D Engineer Expanscience Laboratories, Damascus, Syria

-Performed new control methods -Validation of quality control protocols.


Compétences

Formulation Drug Delivery Encapsulation Vaccine development

Publications

Publications

Oxygen uptake rate analysis to evaluate the impact of hydrodynamic stress on the growth of the avian cell line DuckCelt®-T17

Valentine Tingaud , Philippe Lawton , Johan Peralez , Madiha Nadri-Wolf , Isabelle Pitault et al.
Biochemical Engineering Journal, 2024, 212, pp.109520. ⟨10.1016/j.bej.2024.109520⟩
Article dans une revue hal-04760064 v1
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Hybrid core-shell particles for mRNA systemic delivery

Valentina Andretto , Mathieu Repellin , Marine Pujol , Eyad Almouazen , Jacqueline Sidi-Boumedine et al.
Journal of Controlled Release, 2023, 353, pp.1037-1049. ⟨10.1016/j.jconrel.2022.11.042⟩
Article dans une revue hal-04082346 v1
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Experimental studies from shake flasks to 3 L stirred tank bioreactor of nutrients and oxygen supply conditions to improve the growth of the avian cell line DuckCelt®-T17

Valentine Tingaud , Claire Bordes , Eyad Al Mouazen , Claudia Cogné , Marie-Alexandrine Bolzinger et al.
Journal of Biological Engineering, 2023, 17 (1), pp.31. ⟨10.1186/s13036-023-00349-5⟩
Article dans une revue (data paper) hal-04134906 v1
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Development of an oral nanovaccine for dogs against Echinococcus granulosus

Marine Leroux , Uruguaysito Benavides , Imène Hellel-Bourtal , Cecilia Silvarrey , Nadège Milhau et al.
European Journal of Pharmaceutics and Biopharmaceutics, 2023, 192, pp.185-195. ⟨10.1016/j.ejpb.2023.09.012⟩
Article dans une revue hal-04504162 v1
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Negatively charged chitosan nanoparticles prepared by ionotropic gelation for encapsulation of positively charged proteins

Melissa Marques Gonçalves , Daniela Florencio Maluf , Roberto Pontarolo , Cyro Ketzer Saul , Eyad Almouazen et al.
International Journal of Pharmaceutics, 2023, 642, pp.123164. ⟨10.1016/j.ijpharm.2023.123164⟩
Article dans une revue hal-04216263 v1
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Imaging of Dysfunctional Elastogenesis in Atherosclerosis Using an Improved Gadolinium-Based Tetrameric MRI Probe Targeted to Tropoelastin

Federico Capuana , Alkystis Phinikaridou , Rachele Stefania , Sergio Padovan , Begoña Lavin et al.
Journal of Medicinal Chemistry, 2021, 64 (20), pp.15250-15261. ⟨10.1021/acs.jmedchem.1c01286⟩
Article dans une revue hal-03433450 v1

Supersaturable self-microemulsifying delivery systems: an approach to enhance oral bioavailability of benzimidazole anticancer drugs

Annalisa Rosso , Eyad Almouazen , Jorge Pontes , Valentina Andretto , Marine Leroux et al.
Drug Delivery and Translational Research, 2021, 11, pp.675-691. ⟨10.1007/S13346-021-00904-X⟩
Article dans une revue hal-03175653 v1
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Iodinated polymer nanoparticles as contrast agent for spectral photon counting computed tomography

Joëlle Balegamire , Marc Vandamme , Emmanuel Chereul , Salim Si-Mohamed , Samira Azzouz Maache et al.
Biomaterials Science, 2020, 8 (20), pp.5715-5728. ⟨10.1039/D0BM01046D⟩
Article dans une revue hal-02946431 v1

In vitro evaluations on canine monocyte-derived dendritic cells of a nanoparticles delivery system for vaccine antigen against Echinococcus granulosus

Nadège Milhau , Eyad Almouazen , Sylvie Bouteille , Imène Hellel-Bourtal , Samira Azzouz-Maache et al.
PLoS ONE, 2020, 15 (2), pp.e0229121. ⟨10.1371/journal.pone.0229121⟩
Article dans une revue hal-04868646 v1
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Comparison of Three Processes for Parenteral Nanoemulsion Production: Ultrasounds, Microfluidizer, and Premix Membrane Emulsification

Océane Alliod , Eyad Almouazen , Georgio Nemer , Hatem Fessi , Catherine Charcosset
Journal of Pharmaceutical Sciences, 2019, 108 (8), pp.2708-2717. ⟨10.1016/j.xphs.2019.03.026⟩
Article dans une revue hal-02362258 v1

Polymeric nanocapsules as drug carriers for sustained anticancer activity of calcitriol in breast cancer cells

Sabrina Nicolas , Marie-Alexandrine Bolzinger , Lars Petter Jordheim , Yves Chevalier , Hatem Fessi et al.
International Journal of Pharmaceutics, 2018, 550 (1-2), pp.170-179. ⟨10.1016/j.ijpharm.2018.08.022⟩
Article dans une revue hal-02139822 v1

Microencapsulation of rifampicin for the prevention of endophthalmitis: In vitro release studies and antibacterial assessment

Mi Yeon Lee , Sandrine Bourgeois , Eyad Almouazen , Jocelyne Pelletier , Francois Renaud et al.
International Journal of Pharmaceutics, 2016, 505 (1-2), pp.262-270. ⟨10.1016/j.ijpharm.2016.03.026⟩
Article dans une revue hal-01814080 v1

Antimicrobial nanocapsules: from new solvent-free process to in vitro efficiency

Damien Salmon , Julie Steelandt , Elodie Gilbert , Eyad Almouazen , Marek Haftek et al.
International Journal of Nanomedicine, In press, pp.4467
Article dans une revue hal-01958387 v1

Antimicrobial nanocapsules: from new solvent-free process to in vitro efficiency

J. Steelandt , D. Salmon , E. Gilbert , E. Almouazen , F.N. Renaud et al.
International Journal of Nanomedicine, 2014, 9, pp.4467-4474. ⟨10.2147/IJN.S64746⟩
Article dans une revue hal-01808035 v1

Nano-encapsulation of Vitamin D3 Active Metabolites for Application in Chemotherapy: Formulation Study and in Vitro Evaluation

Eyad Almouazen , Sandrine Bourgeois , Lars Petter Jordheim , Hatem Fessi , Stéphanie Briançon
Pharmaceutical Research, 2013, 30 (4), pp.1137 - 1146. ⟨10.1007/s11095-012-0949-4⟩
Article dans une revue istex hal-01895860 v1

Development of a nanoparticle-based system for the delivery of retinoic acid into macrophages

Eyad Almouazen , Sandrine Bourgeois , Ali Boussaïd , Pascale Valot , Celine Malleval et al.
International Journal of Pharmaceutics, 2012, 430 (1-2), pp.207-215. ⟨10.1016/j.ijpharm.2012.03.025⟩
Article dans une revue istex hal-01958051 v1

Nanoparticles and macrophages enhance anticancer activity of vitamin D3 metabolites

E. Almouazen , S. Bourgeois , L.P. Jordheim , H. Fessi , S. Briancon
9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2014, Lisbone, Portugal
Communication dans un congrès hal-02013719 v1

Development of nanoparticle delivery system for oral vaccination of dogs

U. Benavides , E. Almouazen , S. Bourgeois , S. Azzouz , S. Briançon et al.
Paravac Meeting, 2014, Cordoba, Spain
Communication dans un congrès hal-01958034 v1

Développement de nanoparticules polymères pour le ciblage et la modulation des macrophages

Eyad Almouazen , Sandrine Bourgeois , Hatem Fessi , Stéphanie Briançon
JOURNÉE LYONNAISE AGENTS D’IMAGERIE " Nanoparticules multimodales pour le diagnostic et la thérapie, 2013, Lyon, France
Communication dans un congrès hal-01958037 v1

Development of polymeric nanoparticles for targeting and modulating macrophage functions

E. Almouazen , S. Bourgeois , H. Fessi , S. Briançon
17ème Journée scientifique de l’EDISS, 2012, Lyon, France
Communication dans un congrès hal-01958047 v1

Development of a nanoparticle-based system for the delivery of retinoic acid into macrophages

E. Almouazen , S. Bourgeois , A. Boussaid , H. Fessi , S. Nataf et al.
8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2012, Istanbul, Turkey
Communication dans un congrès hal-01958045 v1

Development of 25-hydroxyvitamin D3 nanoparticles for application in chemotherapy: formulation study

E. Almouazen , S. Bourgeois , J. Honnorat , S. Briançon
8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2012, Istanbul, Turkey
Communication dans un congrès hal-01958046 v1

Encapsulation of hydrophobic hapten enhances in vitro screening performance of non-soluble skin sensitizing

A. Cortial , E. Almouazen , A. Achachi , V. Mutez , M. Vocanson et al.
Skin and Formulation 4th Symposium, Jun 2012, Lyon, France
Communication dans un congrès hal-02044632 v1

Development of polymeric nanoparticles for targeting and modulating macrophage functions

E. Almouazen , S. Bourgeois , A. Boussaid , S. Briançon , S. Nataf et al.
16ème Journée scientifique de l’EDISS, 2011, Lyon, France
Communication dans un congrès hal-01958057 v1

Development of polymeric nanoparticles for modulating macrophage functions

Eyad Almouazen , S. Bourgeois , Ali Boussaïd , Pascale Valot , S. Briançon et al.
2nd Conference Innovation in Drug Delivery:From preformulation to development through innovative evaluation process, 2010, Aix en Provence, France
Communication dans un congrès hal-01958063 v1

Development of polymeric nanoparticles for modulating macrophage functions: an original strategy of cellular therapy for autoimmune diseases

Eyad Almouazen , S. Bourgeois , Ali Boussaïd , Pascale Valot , S. Briançon et al.
7th world meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2010, Unknown, Malta
Communication dans un congrès hal-01958066 v1