Fabrice Pagniez

Maitre de Conférences
42
Documents

Compétences

Antifungal Antileishmanial In vivo models

Publications

Publications

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Synthesis and Biological Evaluation of Itraconazole Derivatives: Design in an Old Scaffold

Shuai Zhong , Apollonia Kalamatianou , Gonzalo Scalese , Cillian O’beirne , Marta Redrado et al.

Inorganic Chemistry, 2025, 64 (31), pp.16192-16203. ⟨10.1021/acs.inorgchem.5c02730⟩

Article dans une revue hal-05211856v1

Pharmacophore-guided optimization of the hit compound CTN1122 in the design of promising imidazo[1,2- a ]pyrazine derivatives targeting the casein kinase 1 for antileishmanial therapy

Lhana Tisseur , Cédric Logé , Sandrine Cojean , Khadidiatou Gassama , Lilian Karcher et al.

RSC Medicinal Chemistry, 2025, 16, pp.3746-3763. ⟨10.1039/d5md00257e⟩

Article dans une revue hal-05173262v1

Investigating the C2 Modulation of the Imidazo[1,2‐ a ]pyrazine‐Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition

Lhana Tisseur , Sandrine Cojean , Khadidiatou Gassama , Cédric Logé , Fabrice Pagniez et al.

ChemMedChem, 2025, 20 (6), pp.e202400862. ⟨10.1002/cmdc.202400862⟩

Article dans une revue hal-05181232v1

Chemical Composition, Antifungal, Antioxidant, and Hemolytic Activities of Moroccan Thymus capitatus Essential Oil

Amina Amakran , Meriem Hamoudane , Fabrice Pagniez , Ahmed Lamarti , Carine Picot et al.

Chemistry and Biodiversity, 2024, 21 (9), pp.e202300563. ⟨10.1002/cbdv.202300563⟩

Article dans une revue hal-04805121v1
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Discovery of New Broad-Spectrum Anti-Infectives for Eukaryotic Pathogens Using Bioorganometallic Chemistry

Yan Lin , Hyeim Jung , Christina Bulman , James Ng , Robin Vinck et al.

Journal of Medicinal Chemistry, 2023, 66 (23), ⟨10.1021/acs.jmedchem.3c01333⟩

Article dans une revue hal-04311470v1
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CRISPR-Cas9 approach confirms Calcineurin-responsive zinc finger 1 (Crz1) transcription factor as a promising therapeutic target in echinocandin-resistant Candida glabrata

Andres Ceballos-Garzon , Elvira Roman , Jesús Pla , Fabrice Pagniez , Daniela Amado et al.

PLoS ONE, 2022, 17 (3), pp.e0265777. ⟨10.1371/journal.pone.0265777⟩

Article dans une revue hal-04753979v1
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Impact of TR34/L98H, TR46/Y121F/T289A and TR53 Alterations in Azole-Resistant Aspergillus fumigatus on Sterol Composition and Modifications after In Vitro Exposure to Itraconazole and Voriconazole

Rose-Anne Lavergne , Marjorie Albassier , Jean-Benoît Hardouin , Carlos Alvarez-Moreno , Fabrice Pagniez et al.

Microorganisms, 2022, 10 (1), pp.104. ⟨10.3390/microorganisms10010104⟩

Article dans une revue hal-03778408v1
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In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition

Marc-Antoine Bazin , Sandrine Cojean , Fabrice Pagniez , Guillaume Bernadat , Christian Cavé et al.

European Journal of Medicinal Chemistry, 2021, 210, pp.112956. ⟨10.1016/j.ejmech.2020.112956⟩

Article dans une revue pasteur-03108849v1

Antimicrobial and antileishmanial activities of extracts and some constituents from the leaves of Solanum chrysotrichum Schldl

Guillermo Núñez-Mojica , Verónica Rivas-Galindo , Elvira Garza-González , Luis Miranda , Adriana Romo-Pérez et al.

Medicinal Chemistry Research, 2020, 30 (1), pp.152-162. ⟨10.1007/s00044-020-02648-8⟩

Article dans une revue hal-04721673v1
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New azole antifungals with a fused triazinone scaffold

David Montoir , Rémi Guillon , Sophie Gazzola , Isabelle Ourliac-Garnier , Kossi Efouako Soklou et al.

European Journal of Medicinal Chemistry, 2020, 189, pp.112082. ⟨10.1016/j.ejmech.2020.112082⟩

Article dans une revue hal-03412473v1
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Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols

Nicolas Lebouvier , Fabrice Pagniez , Young Min Na , Da Shi , Patricia Pinson et al.

Pharmaceuticals, 2020, 13 (8), ⟨10.3390/ph13080186⟩

Article dans une revue hal-03389414v1
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Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols

Nicolas Lebouvier , Fabrice Pagniez , Young Min Na , Da Shi , Patricia Pinson et al.

Pharmaceuticals, 2020, 13 (8), 186 (32 p.). ⟨10.3390/ph13080186⟩

Article dans une revue hal-02913479v2
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Biological exploration of a novel 1,2,4-triazole-indole hybrid molecule as antifungal agent

Fabrice Pagniez , Nicolas Lebouvier , Young Min Na , Isabelle Ourliac-Garnier , Carine Picot et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35 (1), pp.398-403. ⟨10.1080/14756366.2019.1705292⟩

Article dans une revue hal-02455791v2
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Econazole imprinted textiles with antifungal activity

Mirza Akram Hossain , Fabrice Pagniez , Aicha Benhaddou , Martine Raymond , Karine Théberge et al.

European Journal of Pharmaceutics and Biopharmaceutics, 2016, ⟨10.1016/j.ejpb.2016.02.003⟩

Article dans une revue hal-02512446v1

Identification and Biological Activities of Long-Chain Peptaibols Produced by a Marine-Derived Strain of Trichoderma longibrachiatum

Mustapha Mohamed-Benkada , Yves-François Pouchus , Philippe Vérité , Fabrice Pagniez , Nathalie Caroff et al.

Chemistry and Biodiversity, 2016, 13 (5), pp.521-530. ⟨10.1002/cbdv.201500159⟩

Article dans une revue istex hal-02469759v1

Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines

Pascal Marchand , Marc-Antoine Bazin , Fabrice Pagniez , Guillaume Rivière , Lizeth Bodero et al.

European Journal of Medicinal Chemistry, 2015, 103, pp.381-395. ⟨10.1016/j.ejmech.2015.09.002⟩

Article dans une revue istex hal-03216056v1

Design, synthesis and biological evaluation of novel 4-alkapolyenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents – Part III

Luisa Ronga , Marco del Favero , Anita Cohen , Claire Soum , Patrice Le Pape et al.

European Journal of Medicinal Chemistry, 2014, 81, pp.378-393. ⟨10.1016/j.ejmech.2014.05.037⟩

Article dans une revue istex hal-03800819v1

Discovery of a Novel Broad-Spectrum Antifungal Agent Derived from Albaconazole

Rémi Guillon , Fabrice Pagniez , Carine Picot , Damien Hédou , Alain Tonnerre et al.

ACS Medicinal Chemistry Letters, 2013, 4 (2), pp.288-292. ⟨10.1021/ml300429p⟩

Article dans une revue hal-01015468v1

Deciphering azole resistance mechanisms with a focus on transcription factor-encoding genes TAC1, MRR1 and UPC2 in a set of fluconazole-resistant clinical isolates of Candida albicans

Florent Morio , Fabrice Pagniez , Myriam Besse , Françoise Gay-Andrieu , Michel Miegeville et al.

International Journal of Antimicrobial Agents, 2013, 42 (5), pp.410-415. ⟨10.1016/j.ijantimicag.2013.07.013⟩

Article dans une revue istex hal-03827331v1

Anti-AGEs and antiparasitic activity of an original prenylated isoflavonoid and flavanones isolated from Derris ferruginea

Sylvie Morel , Jean-Jacques Helesbeux , Denis Séraphin , Séverine Derbré , Julia Gatto et al.

Phytochemistry Letters, 2013, 6 (3), pp.498-503. ⟨10.1016/j.phytol.2013.06.002⟩

Article dans une revue hal-05519307v1
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Anti-AGEs and antiparasitic activity of an original prenylated isoflavonoid and flavanones isolated from Derris ferruginea

Sylvie Morel , Jean-Jacques Helesbeux , Denis Séraphin , Séverine Derbré , Julia Gatto et al.

Phytochemistry Letters, 2013, 6 (3), pp.498-503. ⟨10.1016/j.phytol.2013.06.002⟩

Article dans une revue hal-00911058v1
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Preparative Isolation, Fast Centrifugal Partition Chromatography Purification and Biological Activity of Cajaflavanone from Derris ferruginea Stems

Sylvie Morel , Anne Landreau , van Hung Nguyen , Séverine Derbré , Philippe Grellier et al.

Phytochemical Analysis, 2012, 23 (2), pp.152-158. ⟨10.1002/pca.1336⟩

Article dans une revue istex mnhn-02047397v1

Amino acid substitutions in the Candida albicans sterol 5,6-desaturase (Erg3p) confer azole resistance: characterization of two novel mutants with impaired virulence

Florent Morio , Fabrice Pagniez , C. Lacroix , Michel Miegeville , Patrice Le Pape

Journal of Antimicrobial Chemotherapy, 2012, 67 (9), pp.2131-2138. ⟨10.1093/jac/dks186⟩

Article dans une revue hal-03822982v1

Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents

Sophie Marhadour , Pascal Marchand , Fabrice Pagniez , Marc-Antoine Bazin , Carine Picot et al.

European Journal of Medicinal Chemistry, 2012, 58, pp.543-556. ⟨10.1016/j.ejmech.2012.10.048⟩

Article dans une revue istex hal-03882013v1

Design, Synthesis, and in vitro Antifungal Activity of 1-[(4-Substituted-benzyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols

Rémi Guillon , Fabrice Pagniez , Francis Giraud , Damien Crépin , Carine Picot et al.

ChemMedChem, 2011, 6 (5), pp.816 - 825. ⟨10.1002/cmdc.201000530⟩

Article dans une revue istex hal-01689176v1
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Isoquinolines from the Roots of Thalictrum flavum L. and Their Evaluation as Antiparasitic Compounds

Jacqueline Ropivia , Séverine Derbré , Caroline Rouger , Fabrice Pagniez , Patrice Le Pape et al.

Molecules, 2010, 15 (9), pp.6476-6484. ⟨10.3390/molecules15096476⟩

Article dans une revue hal-03247823v1

Synthesis and in vitro antifungal evaluation of 2-(2,4-difluorophenyl)-1-[(1 H -indol-3-ylmethyl)methylamino]-3-(1 H -1,2,4-triazol-1-yl)propan-2-ols

Rémi Guillon , Cédric Logé , Fabrice Pagniez , Véronique Ferchaud-Roucher , Muriel Duflos et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, 2010, 26 (2), pp.261-269. ⟨10.3109/14756366.2010.503607⟩

Article dans une revue hal-04792103v1

Synthesis and structure–activity relationships of 2-phenyl-1-[(pyridinyl- and piperidinylmethyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents

Francis Giraud , Rémi Guillon , Cédric Logé , Fabrice Pagniez , Carine Picot et al.

Bioorganic and Medicinal Chemistry Letters, 2009, 19 (2), pp.301 - 304. ⟨10.1016/j.bmcl.2008.11.101⟩

Article dans une revue istex hal-01689192v1

Design, synthesis and evaluation of 3-(imidazol- 1-ylmethyl)indoles as antileishmanial agents. Part II

Francis Giraud , Cédric Logé , Fabrice Pagniez , Damien Crépin , Sophie Barres et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, 2009, 24 (5), pp.1067 - 1075. ⟨10.1080/14756360802610795⟩

Article dans une revue hal-01689191v1

Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols

Rémi Guillon , Francis Giraud , Cédric Logé , Marc Le Borgne , Carine Picot et al.

Bioorganic and Medicinal Chemistry Letters, 2009, 19 (20), pp.5833 - 5836. ⟨10.1016/j.bmcl.2009.08.089⟩

Article dans une revue istex hal-01689189v1

Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents

Francis Giraud , Cédric Logé , Fabrice Pagniez , Damien Crépin , Patrice Le Pape et al.

Bioorganic and Medicinal Chemistry Letters, 2008, 18 (6), pp.1820 - 1824. ⟨10.1016/j.bmcl.2008.02.027⟩

Article dans une revue istex hal-01689196v1

Antileishmanial polyphenols from Garcinia vieillardii.

Anne-Emmanuelle Hay , Joumaa Merza , Anne Landreau , Marc Litaudon , Fabrice Pagniez et al.

Fitoterapia, 2008, 79 (1), pp.42-46. ⟨10.1016/j.fitote.2007.07.005⟩

Article dans une revue istex hal-00294806v1

Synthesis and antifungal activities of new fluconazole analogues with azaheterocycle moiety

Nicolas Lebouvier , Fabrice Pagniez , Muriel Duflos , Patrice Le Pape , Young Min Na et al.

Bioorganic and Medicinal Chemistry Letters, 2007, 17 (13), pp.3686 - 3689. ⟨10.1016/j.bmcl.2007.04.038⟩

Article dans une revue istex hal-01689197v1

A 3D-QSAR CoMSIA study on 3-azolylmethylindoles as anti-leishmanial agents

Francis Giraud , Cédric Logé , Marc Le Borgne , Fabrice Pagniez , Young Min Na et al.

SAR and QSAR in Environmental Research, 2006, 17 (3), pp.299 - 309. ⟨10.1080/10659360600787494⟩

Article dans une revue hal-01689291v1

Antileishmanial activities and mechanisms of action of indole-based azoles

Fabrice Pagniez , Hiam Abdala-Valencia , Pascal Marchand , Marc Le Borgne , Guillaume Le Baut et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, 2006, 21 (3), pp.277 - 283. ⟨10.1080/14756360600700517⟩

Article dans une revue hal-01689215v1

Synthesis and Antileishmanial Activity of 3-Imidazolylalkylindoles. Part I

Young Min Na , Nicolas Lebouvier , Marc Le Borgne , Fabrice Pagniez , Nidia Alvarez et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, 2004, 19 (6), pp.451 - 457. ⟨10.1080/14756360412331280509⟩

Article dans une revue hal-01689240v1

Synthesis and antifungal activity of new 1-halogenobenzyl-3-imidazolylmethylindole derivatives

Young Min Na , Marc Le Borgne , Fabrice Pagniez , Guillaume Le Baut , Patrice Le Pape

European Journal of Medicinal Chemistry, 2003, 38 (1), pp.75 - 87. ⟨10.1016/S0223-5234(02)00005-3⟩

Article dans une revue istex hal-01689264v1

Synthesis and Antileishmanial Activity of 3-(α-Azolylbenzyl)indoles

Pascal Marchand , Marc Le Borgne , Young Min Na , Fabrice Pagniez , Hiam Abdala et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, 2002, 17 (6), pp.353 - 358. ⟨10.1080/1475636021000005613⟩

Article dans une revue hal-01689261v1

In Vitro Activity of a New Antifungal Azolyl-substituted Indole Against Aspergillus fumigatus

Fabrice Pagniez , Marc Le Borgne , Pascal Marchand , Young Min Na , Guillaume Le Baut et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, 2002, 17 (6), pp.425 - 429. ⟨10.1080/1475636021000005686⟩

Article dans une revue hal-01689259v1