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Fernanda FONSECA

203
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#### **EDUCATION** **Habilitation à Diriger des Recherches (HDR).** Université de Technologie de Compiègne, 2010. Title : « Stabilization of bio functionalities trough an approach combining the understanding of mechanisms and the product-process engineering” **Ph.D. Degree** in **Biotechnology and Process Engineering**, Institut National Agronomique Paris-Grignon (AgroParisTech),**2001**. Ph.D. thesis title: "Influence of cryoprotection and freezing on the acidification activity of thermopile lactic acid bacteria: relationships between biological and thermodynamic properties." **Master Degree** in **Biotechnology and Process Engineering**, Institut National Agronomique Paris-Grignon (AgroParisTech), **1997**. M.Sc. thesis title: "Study of the freezing step on the activity of frozen lactic acid starters." Engineer** in **Chemical Engineering**, Montevideo University (Uruguay), **1996.** **SCIENTIFIC EXPERIENCE** ------------------------- **Research Director (since January 2015),** in Paris-Saclay Food and Bioproduct Engineering research unit (UMR 782 SayFood INRAE-AgroParisTech), Versailles-Grignon Centre, at the French National Institute for Agriculture, Food and Environment (INRAE), France. **Researcher Scientist** (**September 2001 – December 2014**), in the Joint Research Unit for Food Process Engineering and Microbiology (UMR 782 GMPA INRA-AgroParisTech), Versailles-Grignon Centre, Institut National de la Recherche Agronomique (INRA), France. **Main fields of expertise:**Biotechnology and process engineering: fermentation, formulation, and stabilization of bioproducts. - Bioproducts: micro-organisms, proteins, food products. - Stabilization processes: freezing and freeze-drying - Biophysical characterization of bioproducts (thermal analysis, freeze-drying microscopy, Fourier Transformed InfraRed microspectroscopy) **Research approach:** Focusing on biophysical and chemical behaviors of bioproducts during stabilization processes and by relating them to biological and functional responses, to identify and quantify the mechanisms governing the degradation and preservation of bioproducts during the stabilization processes. The ambition is also to find general principles for simplifying and rationalizing the development of newly formulated products and the stabilization process optimization, with particular attention to limiting the environmental impact.

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Publications

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Multi-objective optimization of frozen and freeze-dried Lactobacillus delbrueckii subsp. bulgaricus CFL1 production via the modification of fermentation conditions

Maria de L Tovilla-Coutiño , Stéphanie Passot , Ioan-Cristian Trelea , Marie-Hélène Ropers , Yann Gohon
Journal of Applied Microbiology, 2023, pp.lxad003. ⟨10.1093/jambio/lxad003⟩
Journal articles hal-03951874v1
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Ligilactobacillus salivarius functionalities, applications, and manufacturing challenges

M. Guerrero Sanchez , Stephanie Passot , S. Campoy , M. Olivares , F. Fonseca
Applied Microbiology and Biotechnology, 2022, 106 (1), pp.57-80. ⟨10.1007/s00253-021-11694-0⟩
Journal articles hal-03822336v1
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Insights into lactic acid bacteria cryoresistance using FTIR micro-spectroscopy

Amélie Girardeau , Stephanie Passot , Julie Meneghel , Stéphanie Cenard , Pascale Lieben
Analytical and Bioanalytical Chemistry, 2022, 414 (3), pp.1425-1443. ⟨10.1007/s00216-021-03774-x⟩
Journal articles hal-03552585v1
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Effect of protective agents on the storage stability of freeze‑dried Ligilactobacillus salivarius CECT5713

Maria Guerrero Sanchez , Stéphanie Passot , Sonia Campoy , Monica Olivares , Fernanda Fonseca
Applied Microbiology and Biotechnology, 2022, 106, pp.7235-7249. ⟨10.1007/s00253-022-12201-9⟩
Journal articles hal-03845922v1
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Use of 3D mathematical modelling to understand the heat transfer mechanisms during freeze-drying using high-throughput vials

Juan Patricio Buceta , Stephanie Passot , Bernadette Scutellà , Erwan Bourlés , Fernanda Fonseca
Applied Thermal Engineering, 2022, 207, pp.118099. ⟨10.1016/j.applthermaleng.2022.118099⟩
Journal articles hal-03562611v1
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The transfer temperature from slow cooling to cryogenic storage is critical for optimal recovery of cryopreserved mammalian cells

Peter Kilbride , Julie Meneghel , Fernanda Fonseca , John Morris
PLoS ONE, 2021, 16 (11), pp.e0259571. ⟨10.1371/journal.pone.0259571⟩
Journal articles hal-03446319v1
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Heat Transfer During Freeze-Drying Using a High-throughput vial System in view of Process Scale-up to Serum vials

Juan Patricio Buceta , Ioan Trelea , Bernadette Scutellà , Erwan Bourlés , Fernanda Fonseca
Journal of Pharmaceutical Sciences, 2021, 110 (3), pp.1323-1336. ⟨10.1016/j.xphs.2020.11.029⟩
Journal articles hal-03117931v1
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Dynamic Modeling of Carnobacterium Maltaromaticum CNCM I-3298 Growth and Metabolite Production and Model-Based Process Optimization

Cristian Puentes , Amélie Girardeau , Stephanie Passot , Fernanda Fonseca , Ioan-Cristian Trelea
Foods, 2021, 10 (8), pp.1922. ⟨10.3390/foods10081922⟩
Journal articles hal-03552068v1

FTIR micro-spectroscopy using synchrotron-based and thermal source-based radiation for probing live bacteria

Julie Meneghel , Stéphanie Passot , Frédéric Jamme , Stéphane Lefrançois , Pascale Lieben
Analytical and Bioanalytical Chemistry, 2020, 412 (26), pp.7049-7061. ⟨10.1007/s00216-020-02835-x⟩
Journal articles hal-03004447v1
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Highlighting Protective Effect of Encapsulation on Yeast Cell Response to Dehydration Using Synchrotron Infrared Microspectroscopy at the Single-Cell Level

Thanh Dat Nguyen , Stéphane Guyot , Caroline Pénicaud , Stéphanie Passot , Christophe Sandt
Frontiers in Microbiology, 2020, 11 (6), pp.1887. ⟨10.3389/fmicb.2020.01887⟩
Journal articles hal-02939385v1
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FTIR micro-spectroscopy using synchrotron-based and thermal source-based radiation for probing live bacteria

Julie Meneghel , Stephanie Passot , Frédéric Jamme , Stéphane Lefrançois , Pascale Lieben
Analytical and Bioanalytical Chemistry, 2020, 412 (26), pp.7049-7061. ⟨10.1007/s00216-020-02835-x⟩
Journal articles hal-03824330v1
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The Impact of varying cooling and thawing rates on the quality of cryopreserved human peripheral blood t cells

Jasmin Baboo , Peter Kilbride , Mike Delahaye , Stuart Milne , Fernanda Fonseca
Scientific Reports, 2019, 9 (1), pp.1-13. ⟨10.1038/s41598-019-39957-x⟩
Journal articles hal-02154617v1

Écoconception des aliments, bioproduits, bioprocédés et procédés alimentaires

Caroline Pénicaud , Fernanda Fonseca
Techniques de l'Ingenieur, 2019
Journal articles hal-03086204v1
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Influence of culture conditions on the technological properties of Carnobacterium maltaromaticum CNCM I-3298 starters

Amélie Girardeau , C. Puentes , S. Keravec , P. Peteuil , Ioan-Cristian Trelea
Journal of Applied Microbiology, 2019, 126 (5), pp.1468-1479. ⟨10.1111/jam.14223⟩
Journal articles hal-02154448v1

Factors influencing the membrane fluidity and the impact on production of lactic acid bacteria starters

Fernanda Fonseca , Caroline Pénicaud , E. Elizabeth Tymczyszyn , Andrea Gómez-Zavaglia , Stéphanie Passot
Applied Microbiology and Biotechnology, 2019, 103 (17), pp.6867-6883. ⟨10.1007/s00253-019-10002-1⟩
Journal articles hal-02193909v1
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Physical events occurring during the cryopreservation of immortalized human T cells

Julie Meneghel , Peter Kilbride , John G. Morris , Fernanda Fonseca
PLoS ONE, 2019, 14 (5), pp.e0217304. ⟨10.1371/journal.pone.0217304⟩
Journal articles hal-02154629v1
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Relating transformation process, eco-design, composition and sensory quality in cheeses using PO2 ontology

Caroline Pénicaud , Liliana L. Ibanescu , Thomas Allard , Fernanda F. Fonseca , Stephane S. Dervaux
International Dairy Journal, 2019, 92, pp.1-10. ⟨10.1016/j.idairyj.2019.01.003⟩
Journal articles hal-02043246v1
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A Guide for Ex Vivo Handling and storage of stool samples Intended for Fecal Microbiota transplantation

Sebastian D Burz , Anne-Laure Abraham , Fernanda Fonseca , Olivier David , Audrey Chapron
Scientific Reports, 2019, 9 (1), pp.8897. ⟨10.1038/s41598-019-45173-4⟩
Journal articles hal-02466120v1
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Factors influencing the membrane fluidity and the impact on production of lactic acid bacteria starters

Fernanda Fonseca , Caroline Pénicaud , E. Elizabeth Tymczyszyn , Andrea Gómez-Zavaglia , Stephanie Passot
Applied Microbiology and Biotechnology, 2019, 103 (17), pp.6867-6883. ⟨10.1007/s00253-019-10002-1⟩
Journal articles hal-03824544v1
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Determination of the dried product resistance variability and its influence on the product temperature in pharmaceutical freeze-drying

Bernadette Scutella , Ioan-Cristian Trelea , Erwan Bourlés , Fernanda Fonseca , Stéphanie Passot
European Journal of Pharmaceutics and Biopharmaceutics, 2018, 128, pp.379-388. ⟨10.1016/j.ejpb.2018.05.004⟩
Journal articles hal-01789065v1
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The virtual food system: Innovative models and experiential feedback in technologies for winemaking, the cereals chain, food packaging and eco-designed starter production

Cesar Arturo Aceves-Lara , Violaine Athès , Patrice Buche , Guy Della Valle , Vincent Farines
Innovative Food Science & Emerging Technologies / Innovative Food Science and Emerging Technologies , 2018, Food Science and Technology in France: INRA’s contribution to this area, 46, pp.54-64. ⟨10.1016/j.ifset.2017.10.006⟩
Journal articles lirmm-01651998v1

Nouveaux dispositifs médicaux et nouveau procédé de fabrication pour un transfert de microbiote fécal par voie rectale, sans risque, standardisé et prêt à l’emploi

Jean-François Dubuisson , Catherine Juste , Fernanda Fonseca , Patricia Lepage , Christel Béra Maillet
Journal de Pharmacie Clinique, 2018, 37 (2), pp.73-83
Journal articles hal-02628188v1
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Effect of freeze-dryer design on heat transfer variability investigated using a 3D mathematical model

B. Scutellà , E. Bourlés , Artemio Plana-Fattori , F. Fonseca , D. Flick
Journal of Pharmaceutical Sciences, 2018, 107 (8), pp.2098-2106. ⟨10.1016/j.xphs.2018.04.002⟩
Journal articles hal-01769104v1

Life cycle assessment of the production of stabilized lactic acid bacteria for the environmentally-friendly preservation of living cells

Caroline Pénicaud , Vincent Monclus , Bruno Perret , Stéphanie Passot , Fernanda Fonseca
Journal of Cleaner Production, 2018, 184, pp.847-858. ⟨10.1016/j.jclepro.2018.02.191⟩
Journal articles hal-01784901v1
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How vial geometry variability influences heat transfer and product temperature during freeze-drying

Bernadette Scutella , Stéphanie Passot , Erwan Bourlés , Fernanda Fonseca , Ioan-Cristian Trelea
Journal of Pharmaceutical Sciences, 2017, 106 (3), pp.770-778. ⟨10.1016/j.xphs.2016.11.007⟩
Journal articles hal-01465155v1

Subcellular membrane fluidity of Lactobacillus delbrueckii subsp. bulgaricus under cold and osmotic stress

Julie Meneghel , Stéphanie Passot , Stéphanie Cenard , Matthieu Refregiers , Frédéric Jamme
Applied Microbiology and Biotechnology, 2017, 101 (18), pp.6907 - 6917. ⟨10.1007/s00253-017-8444-9⟩
Journal articles hal-01634459v1

Biophysical characterization of the Lactobacillus delbrueckii subsp. bulgaricus membrane during cold and osmotic stress and its relevance for cryopreservation

Julie Meneghel , Stéphanie Passot , Sébastien Dupont , Fernanda Fonseca
Applied Microbiology and Biotechnology, 2017, 101 (4), pp.1427 - 1441. ⟨10.1007/s00253-016-7935-4⟩
Journal articles hal-01559240v1

Understanding the responses of Saccharomyces cerevisiae yeast strain during dehydration processes using synchrotron infrared spectroscopy

T. Nguyen , Stéphane Guyot , C. C. Penicaud , S. Passot , C. Sandt
Analyst, 2017, 142 (19), pp.3620 - 3628. ⟨10.1039/c7an00257b⟩
Journal articles hal-01616052v1
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3D mathematical modelling to understand atypical heat transfer observed in vial freeze-drying

Bernadette Scutellà , Artemio Plana-Fattori , Stéphanie Passot , E Bourlès , Fernanda Fonseca
Applied Thermal Engineering, 2017, 126, pp.226 - 236. ⟨10.1016/j.applthermaleng.2017.07.096⟩
Journal articles hal-01582545v1
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Draft Genome Sequence of Lactobacillus delbrueckii subsp. bulgaricus CFL1, a Lactic Acid Bacterium Isolated from French Handcrafted Fermented Milk

Julie Meneghel , Eric Dugat-Bony , Françoise Irlinger , Valentin Loux , Marie Vidal
Genome Announcements, 2016, 4 (2), pp.e00052-16. ⟨10.1128/genomea.00052-16⟩
Journal articles hal-03649172v1
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Draft Genome Sequence of Lactobacillus delbrueckii subsp. bulgaricus CFL1, a Lactic Acid Bacterium Isolated from French Handcrafted Fermented Milk

Julie Meneghel , Eric Dugat-Bony , Françoise Irlinger , Valentin Loux , Marie Vidal
Genome Announcements, 2016, 4 (2), pp.e00052-16. ⟨10.1128/genomeA.00052-16⟩
Journal articles hal-01511494v1
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Determination of Intracellular Vitrification Temperatures for Unicellular Micro Organisms under Conditions Relevant for Cryopreservation

Fernanda Fonseca , Julie Meneghel , Stéphanie Cenard , Stéphanie Passot , G. John Morris
PLoS ONE, 2016, 11 (4), pp.e0152939. ⟨10.1371/journal.pone.0152939⟩
Journal articles hal-01565156v1
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Dynamic modelling of the secondary drying stage of freeze-drying reveals distinct desorption kinetics for bound water

Ioan-Cristian Trelea , Fernanda Fonseca , Stéphanie Passot
Drying Technology, 2016, 34 (3), pp.335-345. ⟨10.1080/07373937.2015.1054509⟩
Journal articles hal-01531598v1

Protection of yeast cells in micro-organized shells of natural polyelectrolytes during drying process

Thanh Dat Nguyen , Stéphane Guyot , Christophe Sandt , Caroline Pénicaud , Stéphanie Passot
STP Pharma Pratiques, 2016, 26 (2), pp.133
Journal articles hal-01531646v1

Understanding the cryotolerance of lactic acid bacteria using combined synchrotron infrared and fluorescence microscopies

Stéphanie Passot , Julie Gautier , Frédéric Jamme , Stéphanie Cenard , Paul Dumas
Analyst, 2015, 140 (17), pp.5920-5928. ⟨10.1039/C5AN00654F⟩
Journal articles hal-01536496v1

Cyclopropanation of unsaturated fatty acids and membrane rigidification improve the freeze-drying resistance of Lactococcus lactis subsp lactis TOMSC161

Helene Velly , Marielle Bouix , Stéphanie Passot , Caroline Pénicaud , Helene Beinsteiner
Applied Microbiology and Biotechnology, 2015, 99 (2), pp.907 - 918. ⟨10.1007/s00253-014-6152-2⟩
Journal articles hal-01535230v1
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A binary gas transport model Improves the prediction of mass transfer in freeze drying

Ioan-Cristian Trelea , Fernanda Fonseca , Stéphanie Passot , Denis Flick
Drying Technology, 2015, 33 (15-16), pp.1849-1858. ⟨10.1080/07373937.2015.1040025⟩
Journal articles hal-01269386v1

Cell growth and resistance of Lactococcus lactis subsp lactis TOMSC161 following freezing, drying and freeze-dried storage are differentially affected by fermentation conditions

Helene Velly , Fernanda Fonseca , Stéphanie Passot , Agnes Delacroix-Buchet , Marielle Bouix
Journal of Applied Microbiology, 2014, 117 (3), pp.729 - 740. ⟨10.1111/jam.12577⟩
Journal articles hal-01194098v1
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Physiological and biochemical responses of Yarrowia lipolytica to dehydration induced by air-drying and freezing

Caroline Pénicaud , Sophie Landaud-Liautaud , Frederic Jamme , Pauline Talbot , Marielle Bouix
PLoS ONE, 2014, 9 (10), ⟨10.1371/journal.pone.0111138⟩
Journal articles hal-01195500v1
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Genome Sequence of the Lactic Acid Bacterium Lactococcus lactis subsp. lactis TOMSC161, Isolated from a Nonscalded Curd Pressed Cheese

Hélène Velly , Pierre Renault , Anne-Laure Abraham , Valentin Loux , Agnes Delacroix-Buchet
Genome Announcements, 2014, 2 (6), ⟨10.1128/genomeA.01121-14⟩
Journal articles hal-01193999v1

Synchrotron UV fluorescence microscopy for determining membrane fluidity modification of single bacteria with temperatures

Stéphanie S. Passot , Frederic Jamme , M. Refregiers , Julie J. Gautier , Stéphanie Cenard
Biomedical Spectroscopy and Imaging, 2014, 3 (3), pp.203-210. ⟨10.3233/BSI-140062⟩
Journal articles hal-02629450v1
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A low temperature limit for life on Earth

Andrew Clarke , G. John Morris , Fernanda Fonseca , Benjamin J. Murray , Elizabeth Acton
PLoS ONE, 2013, 8 (6), ⟨10.1371/journal.pone.0066207⟩
Journal articles hal-01190603v1

A low membrane lipid phase transition temperature is associated with a high cryotolerance of [i]Lactobacillus delbrueckii[/i] subspecies [i]bulgaricus[/i] CFL1

Julie J. Gautier , Stéphanie S. Passot , Caroline C. Pénicaud , Herve H. Guillemin , Stéphanie S. Cenard
Journal of Dairy Science, 2013, 96 (9), pp.5591-5602. ⟨10.3168/jds.2013-6802⟩
Journal articles hal-01001061v1

A low temperature limit for life on earth

A. Clark , G.J. Morris , F. Fonseca , B.J. Murray , E. Acton
PLoS ONE, 2013, in press
Journal articles hal-01564482v1

Freezing injury: the special case of the sperm cell

G.J. Morris , E. Acton , B. Murray , F. Fonseca
Cryobiology, 2012, 64, pp.71--80
Journal articles hal-01564145v1
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Critical water activity and amorphous state for optimal preservation of lyophilised lactic acid bacteria

Stéphanie Passot , Stéphanie Cenard , Inès Douania , Ioan Cristian Trelea , Fernanda Fonseca
Food Chemistry, 2012, 132 (4), pp.1699-1705. ⟨10.1016/j.foodchem.2011.06.012⟩
Journal articles hal-01536691v1
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Toward Optimal Operation Conditions of Freeze-Drying Processes via a Multilevel Approach

Luis T. Antelo , Stéphanie Passot , Fernanda Fonseca , Ioan-Cristian Trelea , Antonio A. Alonso
Drying Technology, 2012, 30 (13), pp.1432 - 1448. ⟨10.1080/07373937.2012.686079⟩
Journal articles hal-01053126v1

Freezing injury: The special case of the sperm cell

G. John Morris , Elizabeth Acton , Benjamin J. Murray , Fernanda F. Fonseca
Cryobiology, 2012, 64 (2), pp.71-80. ⟨10.1016/j.cryobiol.2011.12.002⟩
Journal articles hal-02649267v1

Freezing protocol effect on quality properties of fruit tissue according to the fruit, the variety and the stage of maturity

Sophie Chassagne-Berces , Fernanda Fonseca , Morgane Citeau , Michele Marin
LWT - Food Science and Technology, 2010, 43 (9), pp.1441 - 1449. ⟨10.1016/j.lwt.2010.04.004⟩
Journal articles hal-01195463v1

Effect of controlled ice nucleation on primary drying stage and protein recovery in vials cooled in a modified freeze-dryer

Stéphanie Passot , Ioan-Cristian Trelea , Michele Marin , Miquel Galan , G. John Morris
Journal of Biomechanical Engineering, 2009, 131 (7), pp.074511:1-5. ⟨10.1115/1.3143034⟩
Journal articles hal-01537095v1
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Model for Heat and Mass Transfer in Freeze-Drying of Pellets

Ioan-Cristian Trelea , Stephanie Passot , Michele Marin , Fernanda Fonseca
Journal of Biomechanical Engineering, 2009, 131 (7), pp.074501. ⟨10.1115/1.3142975⟩
Journal articles hal-01536947v1

Changes in texture, cellular structure and cell wall composition in apple tissue as a result of freezing

Sophie Chassagne , Cécile Poirier , Marie Francoise Devaux , Fernanda Fonseca , Marc Lahaye
Food Research International, 2009, 42 (7), pp.788-797. ⟨10.1016/j.foodres.2009.03.001⟩
Journal articles hal-01195428v1

Rapidly cooled horse spermatozoa: loss of viability is due to osmotic imbalance during thawing, not intracellular ice formation

G. John Morris , K. Faszer , J. E. Green , D. Draper , B. W. W. Grout
Theriogenology, 2007, 68 (5), pp.804-812
Journal articles hal-02653848v1
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An Interactive Tool for the Optimization of Freeze-Drying Cycles Based on Quality Criteria

Ioan-Cristian Trelea , Stéphanie Passot , Fernanda Fonseca , Michele Marin
Drying Technology, 2007, 25 (5), pp.741-751. ⟨10.1080/07373930701370100⟩
Journal articles hal-01537101v1

Effect of product temperature applied during primary drying on the long-term stability of lyophilized proteins

Stéphanie S. Passot , Fernanda F. Fonseca , Naziha Barbouche , - M. Alarcon-Lorca , - D. Rolland
Pharmaceutical Development and Technology, 2007, 12 (6), pp.543-53
Journal articles hal-02655952v1

Caractérisation et lyophilisation de matrices fromagères

Catherine Béal , Fernanda F. Fonseca , A. Thomas , Michèle Marin
Sciences des aliments = Food science : an international journal of food science and technology, 2006, 26 (1), pp.89-102. ⟨10.3166/sda.26.89-102⟩
Journal articles hal-02653766v1

The high viscosity encountered during freezing in glycerol solutions: effects on cryopreservation

G. John Morris , Martha Goodrich , Elizabeth Acton , Fernanda F. Fonseca
Cryobiology, 2006, 52 (3), pp.323-334. ⟨10.1016/j.cryobiol.2006.01.003⟩
Journal articles hal-02667959v1

Stabilization of frozen Lactobacillus delbrueckii subsp. bulgaricus in glycerol suspensions : freezing kinetics and storage temperature effects

Fernanda F. Fonseca , Michèle Marin , G. J. Morris
Applied and Environmental Microbiology, 2006, 72 (10), pp.6474-6482. ⟨10.1128/aem.00998-06⟩
Journal articles hal-02663860v1

Physical characterisation of formulations for the development of two stable freeze-dried proteins during both dried and liquid storage

Stéphanie S. Passot , Fernanda F. Fonseca , M. Alarcon-Lorca , D. Rolland , Michèle Marin
European Journal of Pharmaceutics and Biopharmaceutics, 2005, 60 (3), pp.335-348. ⟨10.1016/j.ejpb.2005.02.013⟩
Journal articles hal-02679545v1

Effect of sucrose and maltodextrin on the physical properties and survival of air-dried Lactobacillus bulgaricus: an in situ fourier transform infrared spectroscopy study

Harriëtte Oldenhof , Willem F. Wolkers , Fernanda F. Fonseca , Stéphanie S. Passot , Michèle Marin
Biotechnology Progress, 2005, 21 (3), pp.885-892. ⟨10.1021/bp049559j⟩
Journal articles hal-02680835v1

Collapse temperature of bacterial suspensions: the effect of cell type and concentration

Fernanda F. Fonseca , Stéphanie S. Passot , Pascale P. Lieben , Michèle Marin
Cryo Letters, 2004, 25 (4), pp.425-434
Journal articles hal-02672062v1

Collapse temperature of freeze-dried Lactobacillus bulgaricus suspensions and protective media

Fernanda F. Fonseca , Stéphanie S. Passot , O. Cunin , Michèle Marin
Biotechnology Progress, 2004, 20 (1), pp.229-238. ⟨10.1021/bp034136n⟩
Journal articles hal-02679282v1

Improvement of cryopreservation of Lactobacillus delbrueckii subsp. bulgaricus CFL1 with additives displaying different protective effects

Fernanda F. Fonseca , Catherine Béal , Fatma Mihoub , Michèle Marin , Georges G. Corrieu
International Dairy Journal, 2003, 13 (11), pp.917-926. ⟨10.1016/S0958-6946(03)00119-5⟩
Journal articles hal-02680827v1

Improvement of cryopreservation of Lactobacillus delbruekii subsp bulgaricus CFL1 with additives displaying different protective effects

Fernanda F. Fonseca , Catherine Béal , Fatma Mihoub , Michèle Marin , Georges Corrieu
International Dairy Journal, 2003, 13 (11), pp.917-926
Journal articles hal-02673309v1

State diagrams and sorption isotherms of bacterial suspensions and fermented medium

Fernanda F. Fonseca , Jean-Philippe Obert , Catherine Béal , Michèle Marin
Thermochimica Acta, 2001, 366 (2), pp.167-182. ⟨10.1016/S0040-6031(00)00725-5⟩
Journal articles hal-02678486v1

Operating conditions that affect the resistance of lactic acid bacteria to freezing and frozen storage

Fernanda F. Fonseca , Catherine Béal , Georges Corrieu
Cryobiology, 2001, 43 (3), pp.189-198. ⟨10.1006/cryo.2001.2343⟩
Journal articles hal-02681116v1

Resistance to freezing and frozen storage of Streptococcus thermophilus is related to membrane fatty acid composition

Catherine Béal , Fernanda F. Fonseca , Georges Corrieu
Journal of Dairy Science, 2001, 84 (11), pp.2347-2356
Journal articles hal-02670204v1
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Resistance to freezing and to frozen storage of Streptococcus themophilus is related to membrane fatty acid composition

Catherine Béal , Fernanda F. Fonseca , Georges G. Corrieu
Journal of Dairy Science, 2001, 84 (11), pp.2347-2356
Journal articles hal-02670974v1

Method of quantifying the loss of acidification activity of lactic acid starters during freezing and frozen storage

Fernanda F. Fonseca , Catherine Béal , Georges Corrieu
Journal of Dairy Research, 2000, 67 (1), pp.83-90
Journal articles hal-02696403v1

Fructose oligosaccharides as a novel cryoprotectant for mammalian cells

Peter Kilbride , Hugo, A , Julie Meneghel , Jérôme J. Delettre , Romano, N
59th Annual Meeting of the Society for Cryobiology, Jul 2020, Inconnue, France. pp.174
Conference papers hal-03006765v1

Methodological approach towards environmentally friendly processes for preserving lactic acid bacteria

Caroline Pénicaud , Bruno Perret , Stéphanie Passot , Camille Quentier , Fernanda Fonseca
Club des Bactéries Lactiques, Jun 2019, Caen, France
Conference papers hal-02266899v1

Avancées récentes sur la production et la stabilisation de bactéries lactiques à haute fonctionnalité

Stéphanie Passot , Catherine Béal , Fernanda Fonseca
CBL 2019 - 22. Colloque du Club des Bactéries Lactiques, Jun 2019, Caen, France
Conference papers hal-02998766v1

Avancées récentes sur la production et la stabilisation de bactéries lactiques à haute fonctionnalité

Stéphanie Passot , Catherine Béal , Fernanda Fonseca
CBL 2019 - 22. Colloque du Club des Bactéries Lactiques, Jun 2019, Caen, France
Conference papers hal-02268915v1

Complementary analytical approaches improving knowledge on lactic acid bacteria cryoresistance

Amélie Girardeau , Julie Meneghel , Ioan-Cristian Trelea , Stéphanie Passot , Fernanda Fonseca
56. Annual Meeting of the Society for Cryobiology, Jul 2019, San Diego, CA, United States. 166-166 p., ⟨10.1016/j.cryobiol.2019.10.086⟩
Conference papers hal-02266910v1
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Physical events during cryopreservation: consequences on cells’ post-thaw performance and on cryobiological protocols optimisation

Fernanda Fonseca , Julie Meneghel , Peter Kilbride , Stéphanie Passot , G. John Morris
9. International Symposium on Lyophilization of Pharmaceuticals ISLFD, Sep 2019, Ghent, Belgium
Conference papers hal-02734376v1

Development of a simplified lipid model of bacterial membrane to investigate specific interactions with oligosaccharides

Fernanda Fonseca , Michele da Silva Pinto , Julie Meneghel , Pascale Lieben , Stéphanie Passot
56. Annual Meeting of the Society for Cryobiology, Jul 2019, San Diego, CA, United States. pp.173, ⟨10.1016/j.cryobiol.2019.10.109⟩
Conference papers hal-02266911v1

The critical thermal range for controlled rate cooling for mammalian cell cryopreservation

Peter Kilbride , Julie Meneghel , Fernanda Fonseca , John Morris
56. Annual Meeting of the Society for Cryobiology, Jul 2019, San Diego, United States. ⟨10.1016/j.cryobiol.2019.10.118⟩
Conference papers hal-02266912v1

A semi-automatic modelling approach for the production and freeze drying of lactic acid bacteria

Thomas Chabin , Marc Barnabe , Alberto Tonda , Nadia Boukhelifa , Fernanda Fonseca
10. International Conference on Simulation and Modelling in the Food and Bio-Industry, FOODSIM 2018. Eurosis, 2018., Apr 2018, Ghent, Belgium
Conference papers hal-02266291v1

LIDeOGraM: an interactive evolutionary modelling tool

Thomas Chabin , Marc Barnabe , Nadia Boukhelifa , Fernanda Fonseca , Alberto Tonda
13. Biennial International Conference on Artificial Evolution (EA), 2018, CHAM, Switzerland. pp.13, ⟨10.1007/978-3-319-78133-4_14⟩
Conference papers hal-02736924v1

Use of a multi-vial mathematical model to design freeze-drying cycles for pharmaceuticals at known risk of failure

Bernadette Scutellà , Ioan-Cristian Trelea , Erwan Bourlés , Fernanda Fonseca , Stéphanie Passot
21. International Drying Symposium, Sep 2018, Valencia, Spain. ⟨10.4995/IDS2018.2018.7421⟩
Conference papers hal-02266914v1

Les bactéries lactiques sous la lumière du synchrotron pour comprendre les mécanismes de cryotolérance

Stéphanie Passot , Frederic Jamme , Mathieu Réfrégiers , Julie Meneghel , Paul Dumas
Société Française de Microbiologie, Oct 2017, Paris, France
Conference papers hal-02266902v1
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Interactive evolutionary modelling of living complex food systems

Thomas Chabin , Marc Barnabe , Nadia Boukhelifa , Fernanda Fonseca , Alberto Tonda
Genetic and Evolutionary Computation Conference GECCO' 17, Jul 2017, Berlin, Germany. ⟨10.1145/3067695.3075992⟩
Conference papers hal-01607872v1

Stabilisation d'écosystèmes microbiens fromagers : preuve de concept

Francoise Irlinger , Wenfan Cao , Thomas Cattenoz , Stéphanie Passot , Marie Noelle Leclercq-Perlat
Société Française de Microbiologie, Oct 2017, Paris, France
Conference papers hal-02266905v1
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LIDeOGraM : an interactive evolutionary modelling tool

Thomas Chabin , Marc Barnabe , Nadia Boukhelifa , Fernanda Fonseca , Alberto Tonda
Biennial International Conference on Artificial Evolution (EA-2017), 2017, Paris, France
Conference papers hal-01607681v1

Can the desorption kinetics explain the residual moisture content heterogeneity observed in pharmaceuticals freeze-drying process?

Bernadette Scutella , Erwan Bourlés , Cassandre Tordjman , Fernanda Fonseca , Yves Mayeresse
6. European Drying Conference: EuroDrying 2017, Jun 2017, Liège, Belgium
Conference papers hal-01604833v1

Eco-design of food and bio-processes: Example of production of stabilized lactic acid bacteria

Caroline Pénicaud , Vincent Monclus , Bruno Perret , Stéphanie Passot , Ioan-Cristian Trelea
Lecture at WUR, Sep 2016, Wageningen, Netherlands
Conference papers hal-01532620v1
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Finite elements model of heat transfer predicts the edge vial effect in different freeze-drying configurations

Bernadette Scutella , Stéphanie Passot , Erwan Bourlés , Fernanda Fonseca , Artemio Plana-Fattori
2016 CPPR Conference Freeze-Drying of Pharmaceuticals and Biologicals, Jul 2016, Breckenridge, United States
Conference papers hal-01567200v1

Production of stabilized lactic acid bacteria viewed from a life cycle assessment perspective

Caroline Pénicaud , Vincent Monclus , Bruno Perret , Stéphanie Passot , Fernanda Fonseca
LCA Food 2016, Oct 2016, Dublin, Ireland
Conference papers hal-01532621v1
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Mapping membrane fluidity in single bacterial cells to study the impact of cryopreservation and its related stresses

Julie Meneghel , Stéphanie Passot , Stéphanie Cenard , Matthieu Refregiers , Frédéric Jamme
2. International Conference on Physics and Biological Systems 2016, Oct 2016, Gif-sur-Yvette, France
Conference papers hal-02268917v1
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Freeze-drying control by taking into account environmental considerations (communication orale)

Caroline Pénicaud , Ioan Cristian Tréléa , Bruno Perret , Fernanda Fonseca , Stéphanie Passot
FoodFactory, Oct 2016, Laval, France
Conference papers hal-01589685v1

How to manage scale-up using the design space approach

Bernadette Scutella , Erwan Bourlés , Fernanda Fonseca , Artemio Plana-Fattori , Denis Flick
2016 PDA Conference, Pharmaceutical Freeze Drying Technology, PDA., Sep 2016, Strasbourg, France
Conference papers hal-01567201v1

Initial measurement of the intracellular glass transition of a mammalian cell type under cryopreservation conditions

Fernanda Fonseca , Julie Meneghel , Stéphanie Cenard , Stéphanie Passot , D. Gilham
52nd Annual Meeting of the Society for Crryobiology, Jul 2015, Ostrava, Czech Republic. pp.538, ⟨10.1016/j.cryobiol.2015.10.008⟩
Conference papers hal-01535362v1

Dynamic characterization of membrane biophysical properties to better understand bacterial tolerance to osmotic and cold stresses encountered during freezing

Julie Meneghel , Stéphanie Passot , Frederic Jamme , Matthieu Refregiers , Stéphanie Cenard
Microbial Stress: from molecules to systems, Nov 2015, Sitges, Spain
Conference papers hal-01535361v1

Inter-vial heat transfer heterogeneity during freeze-drying: role of vial geometry and position on the shelf

Bernadette Scutella , Stéphanie Passot , Erwan Bourlés , Fernanda Fonseca , Ioan-Cristian Trelea
7. International Conference ISL-FD, Jul 2015, Barcelona, Spain
Conference papers hal-01567216v1

Environmentally eco-reasoned design process for functional yeast production and stabilization

Antonio Camarasa Junior , Thanh Dat Nguyen , Hélène Simonin , Rémi Saurel , Anne Endrizzi
3. European Congress of Applied Biotechnology (ECAB 3), Sep 2015, Nice, France
Conference papers hal-02266908v1

Life cycle assessment for an eco-friendly management of the production of stabilized microorganisms

Vincent Monclus , Caroline Pénicaud , Bruno Perret , Stéphanie Passot , Fernanda Fonseca
Life Cycle Management 2015, Aug 2015, Bordeaux, France
Conference papers hal-01536576v1
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Challenges underlying the in situ analysis of single bacterial cells by synchrotron FTIR spectromicroscopy

Julie Meneghel , Stéphane Lefrançois , Stéphanie Passot , Frédéric Jamme , Fernanda Fonseca
European Conference on the Spectroscopy of Biological Molecules (ECSBM 16), Sep 2015, Bochum, Germany
Conference papers hal-02269493v1

Using Raman spectroscopy to understand the osmotic stress response of lactic acid bacteria

Julie Meneghel , Jiawei Xu , Stéphanie Cenard , Dhruvananda Sockalingum , Stéphanie Passot
XXI. Journées du Groupe Français de Spectroscopies Vibrationnelles (GFSV), Jun 2015, Reims, France
Conference papers hal-01536574v1

A mutual gas diffusion model improves the prediction of mass transfer in freeze-drying (communication orale)

Ioan Cristian Tréléa , Fernanda Fonseca , Stéphanie Passot , Denis Flick
IDS 2014 - 19th International Drying Symposium, Aug 2014, Lyon, France
Conference papers hal-01598173v1

Lyophilisation: impact sur la valeur nutritionnelle des aliments

Stéphanie Passot , Fernanda Fonseca
Journées d'Etude de l'Association Française des Diététiciens et Nutritionnistes, Jun 2014, Marseille, France
Conference papers hal-01628106v1

How to increase freeze-drying recovery of biological products by manipulating the ice crystal morphology

Stéphanie Passot , Fernanda Fonseca , J. Skepper , G.J. Morris
45. Annual Conference of the British Association for Crystal Growth, Jul 2014, Leeds, United Kingdom
Conference papers hal-01628115v1

Synchrotron UV fluorescence microscopy for determining membrane fluidity modification of single bacteria with temperatures

Stéphanie S. Passot , Frédéric Jamme , Matthieu M. Refregiers , Julie J. Gautier , Stéphanie S. Cenard
European Conference on Spectroscopy of Biological Molecules XV, Aug 2014, Oxford, United Kingdom. pp.203-210, ⟨10.3233/BSI-140062⟩
Conference papers hal-01584095v1

Freeze-drying modeling: prediction of spatial distribution of product quality

Stéphanie Passot , Fernanda Fonseca , Stéphanie Cenard , Ioan Cristian Tréléa
The Freeze Drying of Pharmaceuticals and Biologicals Conference, Sep 2014, Garmisch-Partenkirchen, Germany
Conference papers hal-01598172v1

Insights into freeze-drying energy consumptions for an environmentally-reasoned process control (poster)

Caroline Pénicaud , Ioan Cristian Tréléa , Bruno Perret , Fernanda Fonseca , Violaine Athes
GPE – 4th International Congress on Green Process Engineering, 2014, Seville, Spain. pp.546
Conference papers hal-01598171v1

Analyse environnementale de procédés bio-industriels

Caroline Pénicaud , Thibaut Maury , Stéphanie Passot , Bruno Perret , Fernanda Fonseca
SFGP2013 - XIV. Congrès de la Société Française de Génie des Procédés, Oct 2013, Lyon, France
Conference papers hal-01628125v1

Propriétés de la membrane et résistance à la lyophilisation de ferments lactiques : Intérêt de la mesure de fluidité membranaire par cytométrie en flux

Helene Velly , Fernanda Fonseca , Agnes Delacroix-Buchet , Stéphanie Passot , Marielle Bouix
17. Congrès Annuel de l’Association Française de Cytométrie, Oct 2013, Strasbourg, France
Conference papers hal-01628116v1

Controlling ice nucleation: the Pros & the Cons

Fernanda Fonseca , Stéphanie Passot , Ioan Cristian Tréléa
PDA International Conference of Lyophilization and Freeze-drying, Oct 2013, Dusseldorf, Germany
Conference papers hal-01598177v1

Influence of the membrane phase behaviour and lipid composition on the freezing-resistance of lactic acid bacteria

Julie Gautier , Stéphanie Passot , Stéphanie Cenard , Caroline Pénicaud , Pascale Lieben
Faraday Discussion 161: Lipids and Membrane Biophysics, Sep 2012, London, United Kingdom
Conference papers hal-01628096v1

Towards a better understanding of the freezing resistance of lactic acid bacteria

Stéphanie Passot , Julie Gautier , Caroline Pénicaud , Frederic Jamme , Stéphanie Cenard
International Conference on Membrane Domains, Nov 2012, Dijon, France
Conference papers hal-01628101v1

Real time optimization of freeze-drying of lactic acid bacteria (communication orale)

Stéphanie Passot , Carlos Vilas , Fernanda Fonseca , Stéphanie Cenard , Eva Balsa-Canto
SDDP2012 - 5th International Symposium on Spray Dried Dairy Products, Jun 2012, Saint-Malo, France
Conference papers hal-01598191v1

Developing smart control strategies of freeze-drying of lactic acid bacteria

Stéphanie Passot , Fernanda Fonseca , Stéphanie Cenard , Ioan-Cristian Trelea
5. International Conference on Lyophilization and Freeze Drying, Mar 2012, Bologne, Italy
Conference papers hal-01628100v1

Biophysical and chemical responses of Lb. bulgaricus to freezing by infrared microspectroscopy

J. Gautier , Stéphanie Passot , Frédéric Jamme , Stéphanie Cenard , Fernanda Fonseca
7. Soleil User's Meeting, Jan 2012, Saclay, France
Conference papers hal-01628120v1

Réponse physiologique de Saccharomyces cerevisiae et Yarrowia lipolytica aux conditions de production et de stabilisation

Caroline Pénicaud , Jean-Marie Beckerich , Yvann Pennont , Fernanda Fonseca , Marielle Bouix
Levures, Modèles & Outils – 10ème Rencontre des Levuristes Francophones, Apr 2012, Toulouse, France
Conference papers hal-01628122v1

Developing smart control strategies for the freeze-drying of bacteria

Stéphanie Passot , Fernanda Fonseca , Stéphanie Cenard , Carlos Vilas , Eva Balsa-Canto
ISL-FD: 5th International Conference on Lyophilization and Freeze Drying, 2012, Bologne, Italy
Conference papers hal-01598192v1

Developing smart control strategies for the freeze-drying of bacteria

Stéphanie Passot , Fernanda Fonseca , Stéphanie Cenard , C. Vilas , E. Balsa Canto
EFFoST Annual Meeting, Nov 2012, Montpellier, France
Conference papers hal-01628119v1
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Quality degradation of lactic acid bacteria during the freeze drying process : experimental study and mathematical modelling

Stéphanie S. Passot , Fernanda F. Fonseca , Stéphanie Cenard , Ines Douania , Ioan-Cristian I.-C. Trelea
ICEF 11, International Congress of Engineering and Food, May 2011, Athens, Greece
Conference papers hal-02746624v1

Freeze-drying of lactic acid bacteria : effect of process variables on cell injury

Stéphanie S. Passot , Stéphanie Cenard , Ioan-Cristian I.-C. Trelea , Fernanda F. Fonseca
48. Annual Meeting of the Society for Cryobiology, Jul 2011, Corvallis, Oregon, United States. ⟨10.1016/j.cryobiol.2011.09.055⟩
Conference papers hal-02749196v1

Electronic nose characterization of the quality parameters of freeze-dried bacteria

R. Capuano , M. Santonico , E. Martinelli , R. Paolesse , Stéphanie S. Passot
14. International Symposium on Olfaction and Electronic Nose, May 2011, New York, United States. pp.125-126, ⟨10.1063/1.3626330⟩
Conference papers hal-02745659v1

New trends in lactic acid fermentation in the industrial perspectives

Georges G. Corrieu , Christophe C. Monnet , Fernanda F. Fonseca , Catherine Béal
International Symposium on Fermentation Microorganisms, Nov 2011, Séoul, South Korea
Conference papers hal-02747169v1
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Probing live cellular responses to freezing by infrared spectromicroscopy

Fernanda F. Fonseca , J. Gautier , Stéphanie Cenard , Stéphanie S. Passot , Frederic Jamme
CellNanoSpec 2011, Sep 2011, Porquerolles, France
Conference papers hal-02748928v1
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The physical behavior of food protein's supramolecular structure during freeze-drying

Stéphanie Passot , Fernanda Fonseca , Fabien Brothier , Said Bouhallab
ICEF 11, International Congress of Engineering and Food, May 2011, Athens, Greece
Conference papers hal-01454611v1

Absence of intracellular ice in rapidly cooled spermatozoa

G.J. Morris , Fernanda F. Fonseca
47. Annual Meeting of the Society for Cryobiology, Jul 2010, Bristol, United Kingdom
Conference papers hal-02814970v1

Non-equilibrium ice formation affects the survival of bull sperm at rapid cooling rates

J.E. Green , I.C. Fernandez , B.W.W. Grout , Fernanda F. Fonseca
47. Annual Meeting of the Society for Cryobiology, Jul 2010, Bristol, United Kingdom. ⟨10.1016/j.cryobiol.2010.10.087⟩
Conference papers hal-02754341v1

Water in freeze-dried lactic acid bacteria: Friend or Foe

Stéphanie S. Passot , Stéphanie Cenard , Ioan-Cristian I.-C. Trelea , Ines Douania , Fernanda F. Fonseca
EuroFoodWater, Mar 2010, Reims, France
Conference papers hal-02818597v1

Cryopreservation of Lactobacillus delbrueckii subsp. bulgaricus: towards a quantitative understanding of the cell biophysical response during freezing

Stéphanie S. Passot , Aline Rault , Stéphanie Cenard , Fernanda F. Fonseca
47. Annual Meeting of the Society for Cryobiology, Jul 2010, Bristol, United Kingdom. ⟨10.1016/j.cryobiol.2010.10.039⟩
Conference papers hal-02755152v1

Modeling for risk assessment of quality failures: Application to microorganisms

Stéphanie S. Passot , Ines Douania , Stéphanie Cenard , Fernanda F. Fonseca , Ioan-Cristian I.-C. Trelea
Freeze Drying of Pharmaceuticals and Biologicals Conference, Sep 2010, Garm