Frédéric Jean-Alphonse

Documents

Publications

Targeting the activated allosteric conformation of the endothelin receptor B in melanoma with an antibody-drug conjugate: mechanisms and therapeutic efficacy

Amaury Herbet , Marie Hautière , Frédéric Jean-Alphonse , Delphine Vivier , Christophe Leboeuf et al.

British journal of cancer reports, 2025, 3, pp.3. ⟨10.1038/s44276-024-00109-y⟩

Article dans une revue hal-05283402v1

Trafficking of luteinizing hormone receptor directs the differential signal activation between luteinizing hormone and chorionic gonadotropin

Clara Lazzaretti , Elia Paradiso , Samantha Sperduti , Rachel Richardson , Carmela Perri et al.

International Journal of Biological Macromolecules, 2025, 318 (3), pp.145247. ⟨10.1016/j.ijbiomac.2025.145247⟩

Article dans une revue hal-05190057v1

Endogenous ligands of bovine FFAR2/GPR43 display distinct pharmacological properties

Tainara Cristina Michelotti , Valérie Lamothe , Frédéric Jean-Alphonse , Eric Reiter , Muriel Bonnet et al.

Frontiers in Cell and Developmental Biology, 2025, 13, pp.1645031. ⟨10.3389/fcell.2025.1645031⟩

Article dans une revue hal-05218647v1

An intracellular VHH targeting the Luteinizing Hormone receptor modulates G protein-dependent signaling and steroidogenesis

Camille Gauthier , Pauline Raynaud , Frédéric Jean-Alphonse , Amandine Vallet , Océane Vaugrente et al.

Molecular and Cellular Endocrinology, 2024, 589, pp.112235. ⟨10.1016/j.mce.2024.112235⟩

Article dans une revue hal-04564514v1

Editorial: Pharmacology of endocrine related GPCRs

Francesco de Pascali , Aylin Hanyaloglu , Frédéric Jean-Alphonse , Francesco Potì , Eric Reiter

Frontiers in Endocrinology, 2024, 15, pp.1379108. ⟨10.3389/fendo.2024.1379108⟩

Article dans une revue hal-04525032v1

A single‐domain intrabody targeting the follicle‐stimulating hormone receptor impacts FSH ‐induced G protein‐dependent signalling

Pauline Raynaud , Vinesh Jugnarain , Océane Vaugrente , Amandine Vallet , Thomas Boulo et al.

FEBS Letters, 2024, 598 (2), pp.220-232. ⟨10.1002/1873-3468.14765⟩

Article dans une revue hal-04564581v1

Investigating the effects of steroid hormones on G protein-coupled receptors $in\ vitro$

Mohammed Akli Ayoub , Eric Reiter , Frédéric Jean-Alphonse

LE STUDIUM Multidisciplinary Journal, 2023, 7 (9), pp.58-64. ⟨10.34846/le-studium.126.02.fr.08-2023⟩

Article dans une revue hal-05077676v1

Highly-Sensitive In Vitro Bioassays for FSH, TSH, PTH, Kp, and OT in Addition to LH in Mouse Leydig Tumor Cell

Danièle Klett , Lucie Pellissier , Didier Lomet , Flavie Derouin Tochon , Vincent Robert et al.

International Journal of Molecular Sciences, 2023, 24 (15), pp.12047. ⟨10.3390/ijms241512047⟩

Article dans une revue hal-04206799v1

Combined multiplexed phage display, high-throughput sequencing, and functional assays as a platform for identifying modulatory VHHs targeting the FSHR

Anielka Zehnaker , Amandine Vallet , Juliette Gourdon , Caterina Sarti , Vinesh Jugnarain et al.

International Journal of Molecular Sciences, 2023, 24 (21), pp.15961. ⟨10.3390/ijms242115961⟩

Article dans une revue hal-04274818v1

Research fellowship in antibody fragments targeting ovarian GPCRs to control reproduction

Anielka Zehnaker , Amandine Vallet , Juliette Gourdon , Caterina Sarti , Vinesh Jugnarain et al.

LE STUDIUM Multidisciplinary Journal, 2023, 7, pp.138-149. ⟨10.34846/le-studium.251.05.fr.11-2023⟩

Article dans une revue hal-05077961v1

Biased GPCR signaling by the native parathyroid hormone–related protein 1 to 141 relative to its N-terminal fragment 1 to 36

Karina A Peña , Alex D White , Sofya Savransky , Ignacio Portales Castillo , Frédéric G Jean-Alphonse et al.

Journal of Biological Chemistry, 2022, 298 (9), pp.102332. ⟨10.1016/j.jbc.2022.102332⟩

Article dans une revue hal-03854828v1

Intracellular VHHs to monitor and modulate GPCR signaling

Pauline Raynaud , Camille Gauthier , Vinesh Jugnarain , Frédéric Jean-Alphonse , Eric Reiter et al.

Frontiers in Endocrinology, 2022, 13, pp.1048601. ⟨10.3389/fendo.2022.1048601⟩

Article dans une revue hal-03892398v1

Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation

Alex D. White , Karina A. Peña , Lisa J. Clark , Christian Santa Maria , Shi Liu et al.

Science Signaling, 2021, 14 (703), ⟨10.1126/scisignal.abc5944⟩

Article dans une revue hal-03476364v1

Pharmacological characterization of low molecular weight biased agonists at the follicle stimulating hormone receptor

Francesco de Pascali , Mohammed Akli Ayoub , Riccardo Benevelli , Silvia Sposini , Jordan Lehoux et al.

International Journal of Molecular Sciences, 2021, 22 (18), pp.1-23. ⟨10.3390/ijms22189850⟩

Article dans une revue hal-03351267v1

G q/11 -dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR

Alex White , Frédéric Jean-Alphonse , Fei Fang , Karina Pena , Shi Liu et al.

Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (13), pp.7455-7460. ⟨10.1073/pnas.1918158117⟩

Article dans une revue hal-03117167v1

Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation

Lisa Clark , James Krieger , Alex White , Vasyl Bondarenko , Saifei Lei et al.

Nature Chemical Biology, 2020, 16 (10), pp.1096-1104. ⟨10.1038/s41589-020-0567-0⟩

Article dans une revue hal-03117168v1

PTH hypersecretion triggered by a GABAB1 and Ca2+-sensing receptor heterocomplex in hyperparathyroidism

Wenhan Chang , Chia-Ling Tu , Frédéric Jean-Alphonse , Amanda Herberger , Zhiqiang Cheng et al.

Nature Metabolism, 2020, 2 (3), pp.243-255. ⟨10.1038/s42255-020-0175-z⟩

Article dans une revue hal-03117169v1

Structure and dynamics of the active human parathyroid hormone receptor-1

Li-Hua Zhao , Shanshan Ma , Ieva Sutkeviciute , Dan-Dan Shen , X. Edward Zhou et al.

Science, 2019, 364 (6436), pp.148-153. ⟨10.1126/science.aav7942⟩

Article dans une revue hal-03117165v1

Biased signaling and allosteric modulation at the FSHR

Flavie Landomiel , Francesco de Pascali , Pauline Raynaud , Frédéric Jean-Alphonse , Romain Yvinec et al.

Frontiers in Endocrinology, 2019, 10, pp.148. ⟨10.3389/fendo.2019.00148⟩

Article dans une revue (article de synthèse) hal-02362523v1

Use of backbone modification to enlarge the spatiotemporal diversity of parathyroid hormone receptor-1 signaling via biased agonism

Shi Liu , Frédéric Jean-Alphonse , Alex D. White , Denise Wootten , Patrick M. Sexton et al.

Journal of the American Chemical Society, 2019, 141 (37), pp.14486-14490. ⟨10.1021/jacs.9b04179⟩

Article dans une revue hal-03117166v1

Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport

Qiangmin Zhang , Kunhong Xiao , Jose M. Paredes , Tatyana Mamonova , W. Bruce Sneddon et al.

Journal of Biological Chemistry, 2019, 294 (12), pp.4546 - 4571. ⟨10.1074/jbc.RA119.007421⟩

Article dans une revue hal-02628955v1

Ca 2+ allostery in PTH-receptor signaling

Alex White , Fei Fang , Frédéric Jean-Alphonse , Lisa Clark , Hyun-Jung An et al.

Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (8), pp.3294-3299. ⟨10.1073/pnas.1814670116⟩

Article dans une revue hal-03117164v1

Integration of GPCR signaling and sorting from very early endosomes via opposing APPL1 mechanisms

Silvia Sposini , Frederic G. Jean-Alphonse , Mohammed Akli Ayoub , Affiong Oqua , Camilla West et al.

Cell Reports, 2017, 21 (10), pp.2855-2867. ⟨10.1016/j.celrep.2017.11.023⟩

Article dans une revue hal-02625571v1

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

Yalikun Suofu , Wei Li , Frédéric Jean-Alphonse , Jiaoying Jia , Nicolas Khattar et al.

Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (38), pp.E7997-E8006. ⟨10.1073/pnas.1705768114⟩

Article dans une revue hal-03117160v1

β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ

Frédéric Jean-Alphonse , Vanessa Wehbi , Jingming Chen , Masaki Noda , Juan Taboas et al.

Nature Chemical Biology, 2017, 13 (3), pp.259-261. ⟨10.1038/nchembio.2267⟩

Article dans une revue hal-03117157v1

Cdc42 activation couples fluid shear stress to apical endocytosis in proximal tubule cells

Sohinee Bhattacharyya , Frédéric Jean-Alphonse , Venkatesan Raghavan , Jennifer Mcgarvey , Youssef Rbaibi et al.

Physiological Reports, 2017, 5 (19), pp.1-26. ⟨10.14814/phy2.13460⟩

Article dans une revue hal-03117161v1

Design and validation of the first cell-impermeant melatonin receptor agonist

Florence Gbahou , Erika Cecon , Guillaume Viault , Romain Gerbier , Frédéric Jean-Alphonse et al.

British Journal of Pharmacology, 2017, 174 (14), pp.2409-2421. ⟨10.1111/bph.13856⟩

Article dans une revue hal-02873466v1

Actin-Sorting Nexin 27 (SNX27)-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling

Jennifer Mcgarvey , Kunhong Xiao , Shanna Bowman , Tatyana Mamonova , Qiangmin Zhang et al.

Journal of Biological Chemistry, 2016, 291 (21), pp.10986-11002. ⟨10.1074/jbc.M115.697045⟩

Article dans une revue hal-03117156v1

The polycystin-1, lipoxygenase, and α -toxin domain regulates polycystin-1 trafficking

Yaoxian Xu , Andrew Streets , Andrea Hounslow , Uyen Tran , Frédéric Jean-Alphonse et al.

Journal of the American Society of Nephrology, 2016, 27 (4), pp.1159-1173. ⟨10.1681/ASN.2014111074⟩

Article dans une revue hal-03117155v1

Spatially Restricted G Protein-coupled Receptor Activity via Divergent Endocytic Compartments

Frédéric Jean-Alphonse , Shanna Bowersox , Stanford Chen , Gemma Beard , Manojkumar Puthenveedu et al.

Journal of Biological Chemistry, 2014, 289 (7), pp.3960-3977. ⟨10.1074/jbc.M113.526350⟩

Article dans une revue hal-03117150v1

Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase

Alexandre Gidon , Mohammad Al-Bataineh , Frédéric Jean-Alphonse , Hilary Stevenson , Tomoyuki Watanabe et al.

Nature Chemical Biology, 2014, 10 (9), pp.707-709. ⟨10.1038/nchembio.1589⟩

Article dans une revue hal-03117152v1

Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential

Evanthia Nikolopoulou , Georgia Papacleovoulou , Frédéric Jean-Alphonse , Giulia Grimaldi , Malcolm Parker et al.

Journal of Lipid Research, 2014, 55 (12), pp.2479-2490. ⟨10.1194/jlr.M049551⟩

Article dans une revue hal-03117154v1

Endosomal generation of cAMP in GPCR signaling

Jean-Pierre Vilardaga , Frédéric Jean-Alphonse , Thomas Gardella

Nature Chemical Biology, 2014, 10 (9), pp.700-706. ⟨10.1038/nchembio.1611⟩

Article dans une revue hal-03117153v1

Regulation of GPCR signal networks via membrane trafficking

Frédéric Jean-Alphonse , A.C. Hanyaloglu

Molecular and Cellular Endocrinology, 2011, 331 (2), pp.205-214. ⟨10.1016/j.mce.2010.07.010⟩

Article dans une revue hal-03117149v1

Past, present and future of vasopressin and oxytocin receptor oligomers, prototypical GPCR models to study dimerization processes

M. Cottet , L Albizu , S Perkovska , Frédéric Jean-Alphonse , R Rahmeh et al.

Current Opinion in Pharmacology, 2010, 10 (1), pp.59-66. ⟨10.1016/j.coph.2009.10.003⟩

Article dans une revue istex hal-03117146v1

Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus.

Frédéric Jean-Alphonse , Sanja Perkovska , Marie-Céline Frantz , Thierry Durroux , Catherine Méjean et al.

Journal of the American Society of Nephrology, 2009, 20 (10), pp.2190-203. ⟨10.1681/ASN.2008121289⟩

Article dans une revue inserm-00421838v1

The multifunctional protein GC1q-R interacts specifically with the i3 loop arginine cluster of the vasopressin V-2 receptor

Sebastien Granier , Frederic Jean-Alphonse , Daniel Bacqueville , Arnaud Monteil , Robert Pascal et al.

Regulatory Peptides, 2008, 148, pp.76-87. ⟨10.1016/j.regpep.2008.01.007⟩

Article dans une revue istex hal-00493436v1

Design and synthesis of cyclic and linear peptide-agarose tools for baiting interacting protein partners of GPCRs

Sébastien Granier , Frédéric Jean-Alphonse , Hélène Déméné , Gilles Guillon , Robert Pascal et al.

Bioorganic and Medicinal Chemistry Letters, 2006, 16 (3), pp.521-524. ⟨10.1016/j.bmcl.2005.10.061⟩

Article dans une revue istex hal-03117141v1

β-arrestins and endocrine-related GPCRs

Francesco de Pascali , Pauline Raynaud , Frédéric Jean-Alphonse , Shifa Tahir , Véronique Bozon et al.

Cellular Endocrinology in Health and Disease, Elsevier, pp.445-458, 2021, 978-0-12-819801-8. ⟨10.1016/B978-0-12-819801-8.00021-1⟩

Chapitre d'ouvrage hal-03462802v1

Confocal and TIRF microscopy based approaches to visualize arrestin trafficking in living cells

Frédéric Jean-Alphonse , Silvia Sposini

Biomolecular Interactions Part A, 166, Elsevier, pp.179-203, 2021, Methods in Cell Biology, ⟨10.1016/bs.mcb.2021.06.009⟩

Chapitre d'ouvrage hal-03476372v1

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