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FREDERIC PAIN

Frederic PAIN Associate Professor Universite PAris Saclay , IOGS , Laboratoire Charles Fabry UMR8501
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72
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  • 1051106
Researcher identifiers
  • IdHAL fpain
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Presentation

I am a physicsict and an associate professor at Université Paris Saclay. My research is about instrumentation and methods for preclinical and clinical imaging. During my Ph-D at Institut de Physique Nucléaire in Orsay (France) and in the following years (1998-2006), I have been developping instruments based on the detection of radiolabled tracers, including a miniaturized beta probe for in situ measurement of pharmacokinetics of molecules labeled with beta-emitters such as 18F-FDG or 11C-Raclopride. This preclinical device was also applied to the direct measurement of radiotracer input function (an important parameter for compartmental modelling of tracer uptake) without blood sampling. In 2006, I moved to optical imaging for functional imaging of the rat and mice brain and more precisely to the study the neurovascular coupling. In close collaboration with neurophysiologists, I have developped several imaging set-ups including intrinsic optical imaging (oxymetry mapping), autofluorescence imaging (mitochondrial activity mapping) and laser speckle imaging ( microvascularization and blood flow mapping). I currently develop new methodological approaches for multiple exposure laser speckle imaging for preclinical (mice obesity models) and clinical (skin microcirculation imaging) applications. Additionnaly ,I have had a continuous interest for modeling and Monte Carlo simulations in the context of biomedical imaging.

Research domains

Physics [physics] Bioengineering Engineering Sciences [physics]

Skills

Publications

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Design and validation of a convolutional neural network for fast, model-free blood flow imaging with multiple exposure speckle imaging

Chao-Yueh Yu , Marc Chammas , Hirac Gurden , Hsin-Hon Lin , Frédéric Pain
Biomedical optics express, 2023, 14 (9), pp.4439. ⟨10.1364/boe.492739⟩
Journal articles hal-04202548v1
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Determination of scattering coefficient and scattering anisotropy factor of tissue-mimicking phantoms using line-field confocal optical coherence tomography (LC-OCT)

Léna Waszczuk , Jonas Ogien , Frederic Pain , Arnaud Dubois
Journal of the European Optical Society : Rapid publications, 2023, 19 (2), pp.39. ⟨10.1051/jeos/2023037⟩
Journal articles hal-04282160v1
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Synthetic exposure with a CMOS camera for multiple exposure speckle imaging of blood flow

Marc Chammas , Frederic Pain
Scientific Reports, 2022, 12 (1), pp.4708. ⟨10.1038/s41598-022-08647-6⟩
Journal articles hal-03613562v1
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Obesity in Midlife Hampers Resting and Sensory‐Evoked Cerebral Blood Flow in Mice

Haleh Soleimanzad , Mireia Montaner , Gaëtan Ternier , Mathilde Lemitre , Jean-Sébastien Silvestre
Obesity, 2020, 29 (1), pp.150-158. ⟨10.1002/oby.23051⟩
Journal articles hal-03048891v1
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MAPSSIC, a Novel CMOS Intracerebral Positrons Probe for Deep Brain Imaging in Awake and Freely Moving Rats: A Monte Carlo Study

L. Ammour , J. Heymes , M. Bautista , S. Fieux , F. Gensolen
IEEE Transactions on Radiation and Plasma Medical Sciences, 2019, 3 (3), pp.302-314. ⟨10.1109/TRPMS.2018.2881301⟩
Journal articles hal-02165345v1
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Optical and thermal simulations for the design of optodes for minimally invasive optogenetics stimulation or photomodulation of deep and large cortical areas in non-human primate brain

Albertine Dubois , Chih-Chieh Chiang , F. Smekens , S. Jan , V Cuplov
Journal of Neural Engineering, 2018, 15 (6), pp.065004. ⟨10.1088/1741-2552/aadf97⟩
Journal articles hal-01929085v1
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Optical properties of mice skull bone in the 455- to 705-nm range

Haleh Soleimanzad , Hirac Gurden , Frederic Pain
Journal of Biomedical Optics, 2017, 22 (1), pp.010503. ⟨10.1117/1.JBO.22.1.010503⟩
Journal articles hal-02335596v1
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Experimental assessment of the safety and potential efficacy of high irradiance photostimulation of brain tissues

Suhan Senova , Ilona Sisniak , Chih-Chieh Chiang , Isabelle Doignon , Stéphane Palfi
Scientific Reports, 2017, 7, pp.43997. ⟨10.1038/srep43997⟩
Journal articles hal-01624076v1
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Simulation of nanoparticle-mediated near-infrared thermal therapy using GATE

Vesna Cuplov , Frederic Pain , Sébastien Jan
Biomedical optics express, 2017, 8 (3), pp.1665-1681. ⟨10.1364/BOE.8.001665⟩
Journal articles hal-01624184v1

Design of an optimized distal optic for non linear endomicroscopy

Claire Lefort , David Sevrain , Hussein Hamzeh , Philippe Leproux , Frederic Pain
Photoptics, 2015, pp.1
Journal articles hal-01127235v1

PIXSIC, a Pixelated β(+)-Sensitive Probe for Radiopharmacological Investigations in Rat Brain: Binding Studies with [(18)F]MPPF.

Laure Balasse , Julia Maerk , Frédéric Pain , Aurélie Genoux , Sylvain Fieux
Molecular Imaging and Biology, 2015, 17 (2), pp.163-167. ⟨10.1007/s11307-014-0785-5⟩
Journal articles hal-01105052v1

Optimization and characterization of a nonlinear excitation and collection through a Gradient-index lens for high resolution nonlinear endomicroscopy of brain tissues

Hussein Hamzeh , Claire Lefort , Frederic Pain , Darine Abi Haidar
Chinese Optics Letters, 2015, pp.808-811
Journal articles hal-01127214v1

Optimization and characterization of nonlinear excitation and collection through a gradient-index lens for high-resolution nonlinear endomicroscopy

Hussein Hamzeh , Claire Lefort , Frederic Pain , Darine Abi Haidar
Optics Letters, 2015, 40, pp.808-811. ⟨10.1364/OL.40.000808⟩
Journal articles hal-01218491v1
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PIXSIC: A Wireless Intracerebral Radiosensitive Probe in Freely Moving Rats

Laure Balasse , Julia Maerk , Frédéric Pain , Aurélie Genoux , Sylvain Fieux
Molecular Imaging, 2015, 14 (484–489), ⟨10.2310/7290.2015.00020⟩
Journal articles in2p3-01235714v1

Functional ultrasound imaging reveals different odor-evoked patterns of vascular activity in the main olfactory bulb and the anterior piriform cortex

Frederic Pain , F. Osmanski , C. Martin , G. Montaldo , P. Laniece
NeuroImage, 2014, 95, pp.176 - 184. ⟨10.1016/j.neuroimage.2014.03.054⟩
Journal articles hal-01624079v1

Characterization, comparison, and choice of a commercial double-clad fiber for nonlinear endomicroscopy

Claire Lefort , Hussein Hamzeh , Frédéric Louradour , Frederic Pain , Darine Abi Haidar
JBO, 2014, 19 (7), pp.076005
Journal articles hal-01063851v1
Image document

Extension of the GATE Monte-Carlo simulation package to model bioluminescence and fluorescence imaging

Vesna Cuplov , Iréne Buvat , Frederic Pain , Sébastien Jan
Journal of Biomedical Optics, 2014, ⟨10.1117/1.JBO.19.2.026004⟩
Journal articles hal-01316110v1

A wireless beta-microprobe based on pixelated silicon for in vivo brain studies in freely moving rats

Julia Maerk , Didier Benoit , Laure Balasse , Mathieu Benoit , Jean-Claude Clémens
Physics in Medicine and Biology, 2013, 58, pp.4483 - 4500. ⟨10.1088/0031-9155/58/13/4483⟩
Journal articles in2p3-00837658v1
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Experimental and analytical comparative study of optical coefficient of fresh and frozen rat tissues

Mohammed Mesradi , Aurelie Genoux , Vesna Cuplov , Darine Abi Haidar , Sebastien Jan
Journal of Biomedical Optics, 2013, ⟨10.1117/1.JBO.18.11.117010⟩
Journal articles hal-01316109v1
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Multispectral reflectance imaging of brain activation in rodents: methodological study of the differential path length estimations and first in vivo recordings in the rat olfactory bulb

Rémi Renaud , Claire Martin , Hirac Gurden , Frederic Pain
Journal of Biomedical Optics, 2012, 17 (1), ⟨10.1117/1.JBO.17.1.016012⟩
Journal articles hal-01316107v1
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Visualizing odor representation in the brain: a review of imaging techniques for the mapping of sensory activity in the olfactory glomeruli

Frederic Pain , B. L’heureux , H. Gurden
Cellular and Molecular Life Sciences, 2011, 68 (16), pp.2689 - 2709. ⟨10.1007/s00018-011-0708-4⟩
Journal articles hal-01694184v1

New concept of a submillimetric pixellated Silicon detector for intracerebral application

M. Benoit , J. Märk , P. Weiss , D. Benoit , J.C. Clemens
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2011, 659, pp.499-503. ⟨10.1016/j.nima.2011.08.027⟩
Journal articles in2p3-00618519v1

PIXSIC: A Pixellated Beta-Microprobe for Kinetic Measurements of Radiotracers on Awake and Freely Moving Small Animals

J. Godart , P. Weiss , B. Chantepie , J. C. Clémens , P. Delpierre
IEEE Transactions on Nuclear Science, 2010, 57, pp.998-1007. ⟨10.1109/TNS.2010.2044804⟩
Journal articles in2p3-00529435v1
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A method based on Monte Carlo simulations and voxelized anatomical atlases to evaluate and correct uncertainties on radiotracer accumulation quantitation in beta microprobe studies in the rat brain

Frederic Pain , Marc Dhenain , Hirac Gurden , Anne-Lise Routier , Françoise Lefebvre
Physics in Medicine and Biology, 2008, 53 (19), pp.5385 - 5404. ⟨10.1088/0031-9155/53/19/008⟩
Journal articles hal-01694187v1

The potential of a radiosensitive intracerebral probe to monitor 18F-MPPF binding in mouse hippocampus in vivo

A. Desbrée , M. Verdurand , J. Godart , André Dubois , R. Mastrippolito
Journal of Nuclear Medicine, 2008, 49 (7), pp.1155-1161. ⟨10.2967/jnumed.107.050047⟩
Journal articles hal-03002294v1

Simultaneous in vivo magnetic resonance imaging and radioactive measurements with the β-MicroProbe

A. Desbrée , L. Rbah , J.-B. Langlois , D. Grenier , R. Mastrippolito
European Journal of Nuclear Medicine and Molecular Imaging, 2007, 34 (11), pp.1868-1872. ⟨10.1007/s00259-007-0475-5⟩
Journal articles hal-03015570v1

Simultaneous in vivo Magnetic Resonance Imaging and Radioactive Measurements by the B-MicroProbe

A. Desbrée , L. Rbah , J. B. Langlois , D. Grenier , R. Mastrippolito
European Journal of Nuclear Medicine and Molecular Imaging, 2007, 34 (11), pp.1868-72
Journal articles hal-00443228v1

A new multimodality system for quantitative in vivo studies in small animals: combination of nuclear magnetic resonance and the radiosensitive$\beta$-MicroProbe

A. Desbree , Frederic Pain , H. Gurden , L. Pinot , D. Grenier
IEEE Transactions on Nuclear Science, 2005, 52, pp.1281-1287. ⟨10.1109/TNS.2005.858216⟩
Journal articles in2p3-00025341v1

A new multimodality system for quantitative in vivo studies in small animals: combination of nuclear magnetic resonance and the radiosensitive beta-MicroProbe

E. A. Desbré , Frederic Pain , H. Gurden , L. Pinot , D. Grenier
IEEE Transactions on Nuclear Science, 2005, 52 (5), pp.1281-1287
Journal articles hal-00443227v1

Combining the radiosensitive Beta MicroProbe to Nuclear Magnetic Resonance: theoretical approach for in vivo studies in small animals

A. Desbrée , Frederic Pain , H. Gurden , L. Zimmer , L. Pinot
Journal of Neuroscience Methods, 2004, 140, pp.47-52. ⟨10.1016/j.jneumeth.2004.03.029⟩
Journal articles in2p3-00025780v1
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Arterial input function measurement without blood sampling using a β-microprobe in rats

Frederic Pain , Philippe Lanièce , Roland Mastrippolito , Philippe Gervais , Philippe Hantraye
Journal of Nuclear Medicine, 2004, 45 (9), pp.1577-1582
Journal articles hal-01694183v1

SIC: an intracerebral radiosensitive probe for in vivo neuropharmacology investigations in small laboratory animals: prototype design, characterization, and in vivo evaluation

Frederic Pain , P. Laniece , R. Mastrippolito , L. Pinot , Y. Charon
IEEE Transactions on Nuclear Science, 2002, 49, pp.822-826
Journal articles in2p3-00012351v1

The potential of the β-Microprobe, an intracerebral radiosensitive probe, to monitor the [18F]MPPF binding in the rat dorsal raphe nucleus

L. Zimmer , Frederic Pain , G. Mauger , A. Plenevaux , D. Le Bars
European Journal of Nuclear Medicine and Molecular Imaging, 2002, 29, pp.1237-1247. ⟨10.1007/s00259-002-0866-6⟩
Journal articles in2p3-00023833v1
Image document

In vivo quantification of localized neuronal activation and inhibition in the rat brain using a dedicated high temporal-resolution β+-sensitive microprobe

Frederic Pain , Laurent Besret , Françoise Vaufrey , M.-C. Gregoire , Laurent Pinot
Proceedings of the National Academy of Sciences of the United States of America, 2002, 99 (16), pp.10807 - 10812. ⟨10.1073/pnas.162368899⟩
Journal articles hal-01624226v1

SIC, an intracerebral beta(+)-range-sensitive probe for radiopharmacology investigations in small laboratory animals: Binding studies with C-11-raclopride

L. Zimmer , W. Hassoun , Frederic Pain , F. Bonnefoi , P. Laniece
Journal of Nuclear Medicine, 2002, 43, pp.227-233
Journal articles in2p3-00013611v1

SIC, an intracerebral radiosensitive probe for In Vivo Neuropharmacology Investigations is Small Laboratory Animals: Theoretical Considerations and Physical Characteristics

Frederic Pain , P. Laniece , R. Mastrippolito , Y. Charon , D. Comar
IEEE Transactions on Nuclear Science, 2000, 47, pp.25-32
Journal articles in2p3-00023052v1

Evaluation of convolutional neural networks as an alternative for the non-linear fitting for multiple exposure speckle imaging of blood flow

Marc Chammas , Chao-Yueh Yu , Hirac Gurden , Frederic Pain , Hsin-Hon Lin
European Conferences on Biomedical Optics, SPIE-OSA, Jun 2023, Munich (Allemagne), Germany
Conference papers hal-04392992v1

Blood flow mapping using machine learning analysis of multiple exposure speckle imaging data

Chao-Yueh Yu , Marc Chammas , Frédéric Pain , Hsin-Hon Lin
Clinical Biophotonics II, SPIE, Apr 2022, Strasbourg, France. pp.13, ⟨10.1117/12.2619163⟩
Conference papers hal-04247758v1

Artefactual movement bias quantitation for multiple exposure speckle imaging of blood flow using the synthetic exposure approach

Marc Chammas , Chao-Yueh Yu , Hsin-Hon Lin , Frederic Pain
European Conferences on Biolmedical Optics, SPIE; OSA, Apr 2022, Strasbourg, France
Conference papers hal-04400650v1
Image document

Skull optical clearing for longitudinal non invasive optical imaging

H Soleimanzad , M Juchaux , D Crepin , H Gurden , F Pain
SPIE West BIOS 2020, Feb 2020, San Francisco, United States
Conference papers hal-03066940v1

Focus on the Distal Assembly of a Nonlinear Endomicroscope: A Gradient Index Lens Coupled with a Piezoelectric Scanner for Fluorescence Lifetime Measurements

Claire Lefort , Hussein Hamzeh , Liu Wei , Frederic Pain , Darine Abi Haidar
4th International Conference on Photonics, Optics and Laser Technology (PHOTOOPTICS), Mar 2015, Berlin, Germany. pp.19-33
Conference papers hal-01656543v1

Caractérisation, comparaison et choix d'une fibre endomicroscopique à double gaine pour l'endomicroscopie non linéaire

Claire Lefort , Hussein Hamzeh , Frédéric Louradour , Frederic Pain , Darine Abi Haidar
JIONC, Mar 2014, Paris, France
Conference papers hal-01063860v1

Vers un endomicroscope non linéaire multimodal : caractérisation, comparaison et choix d'une fibre optique endomicroscopique à double gaine

Claire Lefort , Hussein Hamzeh , Frédéric Louradour , Frederic Pain , Darine Abi Haidar
Optodiag, May 2014, Paris, France
Conference papers hal-01063859v1

Potential of the wireless radiosensitive intracerebral probe PIXSIC to monitor PET radiotracers in anaesthetized and awake rat

Laure Balasse , Julia Maerk , Sylvain Fieux , Frédéric Pain , Aurélie Genoux
WMIC'2013, World Molecular Imaging Congress, Savannah, Georgia, USA, Sep 2013, Savannah, Georgia, United States
Conference papers in2p3-01069277v1

PIXSIC, a wireless radiosensitive intracerebral probe to monitor PET radiotracers in anaesthetized and awake rat

L. Balasse , J. Maerk , S. Fieux , Frederic Pain , P. Gisquet
Annual Congress of the European Association of Nuclear Medicine 2013, Oct 2013, Lyon, France
Conference papers hal-00948325v1

Optical designs for multimodal nonlinear microendoscope for optical biopsy

Hussein Hamzeh , Claire Lefort , Jamal Charara , Frédéric Louradour , Gael Latour
Advances in Biomedical Engineering (ICABME), 2013, Sep 2013, Tripoli, Lebanon. pp.155-158, ⟨10.1109/ICABME.2013.6648871⟩
Conference papers hal-00914648v1

Optimization of Nonlinear Multimodal Microendoscopy Based on DCF and GRIN Lenses for Optical Biopsy

Hussein Hamzeh , Claire Lefort , Frédéric Louradour , Gaël Latour , Frederic Pain
Frontiers in Optics, Oct 2013, Floride, United States. pp.978-1-55752-987-9
Conference papers hal-00909779v1

Optimization of Nonlinear Multimodal Microendoscopy for Optical Biopsy

Hussein Hamzeh , Claire Lefort , Frederic Pain , Darine Abi Haidar
IONS 2013, Mar 2013, Poland
Conference papers hal-00918826v1

Nutritional impact on odor induced activity in the olfactory buld

Mounir Bendahmane , Marie Jeanne Prud'Homme , C. Martin , F. Pain , Monique Caillol
9. Colloque de la Société des Neurosciences, May 2009, Bordeaux, France
Conference papers hal-02754359v1

Modeles animaux et imagerie

Frederic Pain
Ecole d'Ete de Physique e2phy 2002, Aug 2002, Villeurbanne, France. pp.117-127
Conference papers in2p3-00013855v1

Radio-guidage en chirurgie cancereuse et tomographie d'emission sur modeles animaux en neurosciences

R. Mastrippolito , Y. Charon , Y. Chen , M. Cohen-Solal , A. Glatigny
Rencontre Franco-Marocaine de Physique Nucleaire, Mar 1999, El Jadida, Morocco. pp.43-46
Conference papers in2p3-00006380v1

Active 1xN splitter based on cascaded beam shifters at 1.55 µm

F. Pain , Bruno Vinouze , R. Coquille , Nicole Wolffer , Philippe Gravey
24th European Conference on Optical Communications, Sep 1998, Madrid, Espagne
Conference papers hal-02149354v1

Physical characterization of a wireless radiotracer detection system based on pixalated Silicon for in vivo brain studies in freely moving rats

Julia Maerk , Didier Benoit , Laure Balasse , Mathieu Benoit , Jean-Claude Clémens
IX ième Journée Scientifique BCP, Dec 2012, Marseille, France
Conference poster in2p3-00767714v1

PIXSIC-Characterisation of a Beta+ Intracerebral Wireless Probe for Functtional Imaging Coupled with Behavioural Studies Performed on Freely Moving Rats

Julia Maerk , Laure Balasse , Didier Benoit , Mathieu Benoit , Jean-Claude Clémens
WMIC'2012 World Molecular Imaging Congress, Sep 2012, Dublin, Ireland
Conference poster in2p3-00869594v1

Physical Characterization of a Wireless Radiotracer Detection System Based on Pixelated Silicon for in Vivo Brain Studies in Freely Moving Rats

Julia Maerk , Didier Benoit , Laure Balasse , Mathieu Benoit , Jean-Claude Clémens
2012 Nuclear Science Symposium, Medical Imaging Conference & Workshop on Room-Temperature Semiconductor X-Ray and Gamma-Ray Detectors, Oct 2012, Anaheim, Californie, United States
Conference poster in2p3-00757534v1

New Concept of a Submillimetric Pixellated Silicon Detector for in Vivo Brain Studies in Freely Moving Rodents

J. Maerk , D. Benoit , M. Benoit , J.-C. Clémens , D. Fougeron
2011 World Molecular Imaging Congress, Sep 2011, San Diego, United States
Conference poster in2p3-00628952v1

Nutrition's impact on brain : the nutritive state modifies the spatiotemporal coding in the olfactory buld

Mounir Bendahmane , Claire Martin , Barbara L'Heureux , Frédéric Pain , Christine Baly
Keystone Symposia on cellular and molecular biology : Neuronal control of appetite, metabolism and weight, Jan 2010, Keystone Resort, Colorado, United States. , 2010, Keystone symposia on cellular and molecular biology
Conference poster hal-02754830v1

Nutrition's impact on brain: the nutritive state modifies the spatiotemporal coding in the olfactory bulb

Mounir Bendahmane , Claire Martin , Barbara L'Heureux , Frédéric Pain , Monique Caillol
Keystone Symposia on Cellular and Molecular Biology, Jan 2010, Keystone Resort, United States. 2010
Conference poster hal-02813827v1

Neuro-astrocytic modulation by the nutritional state in the olfactory bulb

Mounir Bendahmane , Marie Jeanne Prud'Homme , R Mounier , Claire Martin , Frédéric Pain
9. European Meeting on Glial Cells in Health and Disease, Sep 2009, Paris, France. Glia, 57, pp.S46-S47, 2009, ⟨10.1002/glia.20915⟩
Conference poster hal-02757261v1

PIXSIC: a Pixellated Radiosensitive Intracerebral Beta Microprobe Allowing the Kinetics Measurements of Radiotracer on Awake and Fully Freely Moving Small Animals

J. Godart , J. Clemens , P. Delpierre , B. Dinskespiler , P. Pangaud
World Molecular Imaging Congress 2008, Sep 2008, Nice, France
Conference poster in2p3-00322279v1