Access content directly

François Guérard

41
Documents

Publications

Image document

Sydnone-based prosthetic groups for radioiodination

Ludovic Le Saux , Ferid Haddad , Jean-François Gestin , Romain Eychenne , François Guérard
Bioorganic and Medicinal Chemistry, 2024, 113, pp.117904. ⟨10.1016/j.bmc.2024.117904⟩
Journal articles inserm-04688208v2
Image document

Astatine-211 radiolabelling chemistry: from basics to advanced biological applications

Maarten Vanermen , Mathilde Ligeour , Maria-Cristina Oliveira , Jean-François Gestin , Filipe Elvas
European Association of Nuclear Medicine, issuing body - EJNMMI radiopharmacy and chemistry, 2024, 9 (1), pp.69. ⟨10.1186/s41181-024-00298-4⟩
Journal articles inserm-04735156v1
Image document

How radiolysis impacts astatine speciation?

Mohammad Ghalei , Parastoo Mahdi Khoshouei , Johan Vandenborre , François Guérard , Guillaume Blain
Radiation Physics and Chemistry, 2022, 198, pp.110224. ⟨10.1016/j.radphyschem.2022.110224⟩
Journal articles inserm-03668885v1
Image document

211At and 125I‐labeling of (hetero)aryliodonium ylides: astatine wins again

Clémence Maingueneau , Marion Berdal , Romain Eychenne , Jöelle Gaschet , Michel Chérel
Chemistry - A European Journal, 2021, ⟨10.1002/chem.202104169⟩
Journal articles hal-03507646v1
Image document

Advances in the chemistry of astatine and implications for the development of radiopharmaceuticals

François Guérard , Clémence Maingueneau , Lu Liu , Romain Eychenne , Jean-François Gestin
Accounts of Chemical Research, 2021, 54 (16), pp.3264. ⟨10.1021/acs.accounts.1c00327⟩
Journal articles inserm-03290202v1
Image document

Investigation on the reactivity of nucleophilic radiohalogens with arylboronic acids in water: access to an efficient single-step method for the radioiodination and astatination of antibodies

Marion Berdal , Sébastien Gouard , Romain Eychenne , Séverine Marionneau-Lambot , Mikaël Croyal
Chemical Science, 2021, 12 (4), pp.1458-1468. ⟨10.1039/D0SC05191H⟩
Journal articles inserm-03024891v1
Image document

Overview of the Most Promising Radionuclides for Targeted Alpha Therapy: The “Hopeful Eight”

Romain Eychenne , Michel Chérel , Férid Haddad , François Guérard , Jean-François Gestin
Pharmaceutics, 2021, 13 (6), pp.906. ⟨10.3390/pharmaceutics13060906⟩
Journal articles inserm-03292397v1
Image document

Cell Tracking in Cancer Immunotherapy

Justine Perrin , Marisa Capitao , Marie Mougin-Degraef , François Guérard , Alain Faivre-Chauvet
Frontiers in Medicine, 2020, 7, pp.34. ⟨10.3389/fmed.2020.00034⟩
Journal articles inserm-02512946v1
Image document

Targeted-Alpha-Therapy Combining Astatine-211 and anti-CD138 Antibody in a Preclinical Syngeneic Mouse Model of Multiple Myeloma Minimal Residual Disease

Sébastien Gouard , Catherine Saï-Maurel , Séverine Marionneau-Lambot , Delphine Dansette , Clément Bailly
Cancers, 2020, 12 (9), pp.2721. ⟨10.3390/cancers12092721⟩
Journal articles inserm-03006927v1
Image document

Reply to the 'Comment on "Investigation of Zr(IV) and 89 Zr(IV) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging"' by A. Bianchi and M. Savastano, Chem. Commun., 2020, 56, D0CC01189D

François Guérard , Yong-Sok Lee , Raphaël Tripier , Lawrence Szajek , Jeffrey Deschamps
Chemical Communications, 2020, Online ahead of print. ⟨10.1039/d0cc03594g⟩
Journal articles inserm-02947405v1
Image document

What is the Best Radionuclide for Immuno-PET of Multiple Myeloma? A Comparison Study Between 89Zr- and 64Cu-Labeled Anti-CD138 in a Preclinical Syngeneic Model

Clément Bailly , Sébastien Gouard , François Guérard , Benjamin Chalopin , Thomas Carlier
International Journal of Molecular Sciences, 2019, 20 (10), pp.2564. ⟨10.3390/ijms20102564⟩
Journal articles hal-02141555v1
Image document

Prosthetic groups for radioiodination and astatination of peptides and proteins: a comparative study of five potential bioorthogonal labeling strategies

Laurent Navarro , Marion Berdal , Michel Chérel , Frédéric Pecorari , Jean-François Gestin
Bioorganic and Medicinal Chemistry, In press, pp.167-174. ⟨10.1016/j.bmc.2018.11.034⟩
Journal articles inserm-01939636v1
Image document

Direct nucleophilic radioiodination and astatination of antibodies via pre-conjugated arylboronic acids

Marion Berdal , Laurent Navarro , Cyrille Alliot , Michel Chérel , Alain Faivre-Chauvet
Journal of Labelled Compounds and Radiopharmaceuticals, 2019
Journal articles inserm-02340736v1
Image document

Efficacy of Astatine-211 radioimmunotherapy of Multiple Myeloma using an anti-mCD138 monoclonal antibody in a syngeneic murine model

Sébastien Gouard , Benjamin Chalopin , Catherine Saï-Maurel , François Guérard , Laurent Navarro
European Journal of Nuclear Medicine and Molecular Imaging, 2018, 45 (1), pp.S166-S167
Journal articles inserm-02341491v1
Image document

Propriétés et applications de l'astate en médecine nucléaire

François Guérard
Les Techniques de l'Ingenieur, 2018
Journal articles inserm-01960094v1
Image document

Bifunctional aryliodonium salts for highly efficient radioiodination and astatination of antibodies

François Guérard , Laurent Navarro , Y.-S. Lee , Aurélia Roumesy , Cyrille Alliot
Bioorganic and Medicinal Chemistry, 2017, Epub ahead of print. ⟨10.1016/j.bmc.2017.09.022⟩
Journal articles inserm-01592684v1
Image document

L’astate-211 pour la radiothérapie vectorisée des cancers

François Guérard
L'Actualité Chimique, 2017, 52, pp.143-144
Journal articles inserm-01628339v1
Image document

Investigation of the complexation of nat Zr(IV) and 89 Zr(IV) by hydroxypyridinones for the development of chelators for PET imaging applications

François Guérard , Maryline Beyler , Y.-S Lee , Raphaël Tripier , Jean-François Gestin
Dalton Transactions, 2017, 46, pp.4749-4758. ⟨10.1039/c6dt04625h⟩
Journal articles inserm-01496515v1
Image document

PET Imaging for Initial Staging and Therapy Assessment in Multiple Myeloma Patients

Clément Bailly , Rodolphe Leforestier , Bastien Jamet , Thomas Carlier , Mickael Bourgeois
International Journal of Molecular Sciences, 2017, 18 (2), pii: E445. ⟨10.3390/ijms18020445⟩
Journal articles inserm-01500327v1
Image document

Radioimmunoconjugates for treating cancer: recent advances and current opportunities

Mickael Bourgeois , Clément Bailly , Mathieu Frindel , François Guérard , Michel Chérel
Expert Opinion on Biological Therapy, 2017, 17 (7), pp.813 - 819. ⟨10.1080/14712598.2017.1322577⟩
Journal articles inserm-01635514v1
Image document

Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts

François Guérard , Yong-Sok Lee , Kwamena Baidoo , Jean-François Gestin , Martin W Brechbiel
Chemistry - A European Journal, 2016, 22 (35), pp.12332-9. ⟨10.1002/chem.201600922⟩
Journal articles inserm-01387016v1
Image document

Immuno-PET for Clinical Theranostic Approaches

Clément Bailly , Pierre-François Cléry , Alain Faivre-Chauvet , Mickael Bourgeois , François Guérard
International Journal of Molecular Sciences, 2016, 18 (1), Epub ahead of print. ⟨10.3390/ijms18010057⟩
Journal articles inserm-01636873v1
Image document

Radioimmunotherapy for Treatment of Acute Leukemia

Caroline Bodet-Milin , Françoise Kraeber-Bodéré , Thomas Eugène , François Guérard , Joëlle Gaschet
Seminars in Nuclear Medicine, 2016, 46, pp.135-146. ⟨10.1053/j.semnuclmed.2015.10.007⟩
Journal articles inserm-01280232v1
Image document

Tumor Immunotargeting Using Innovative Radionuclides

Françoise Kraeber-Bodéré , Caroline Rousseau , Caroline Bodet-Milin , Cédric Mathieu , François Guérard
International Journal of Molecular Sciences, 2015, 16 (2), pp.3932 - 3954. ⟨10.3390/ijms16023932⟩
Journal articles inserm-01818715v1

Which radionuclide, carrier molecule and clinical indication for alpha-immunotherapy?

François Guérard , Jacques Barbet , Ferid Haddad , Michel Cherel , Francoise Kraeber-Bodere
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutic, 2015
Journal articles hal-02415080v1

Investigation of Zr( iv ) and 89 Zr( iv ) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging

François Guérard , Yong-Sok Lee , Raphaël Tripier , Lawrence P. Szajek , Jeffrey R. Deschamps
Chemical Communications, 2013, 49 (10), pp.1002 - 1004. ⟨10.1039/C2CC37549D⟩
Journal articles hal-01555852v1
Image document

Production of [211 At]-Astatinated Radiopharmaceuticals and Applications in Targeted alpha-Particle Therapy

François Guérard , Jean-François Gestin , Martin W Brechbiel
Cancer Biotherapy and Radiopharmaceuticals, 2013, 28 (1), pp.1-20. ⟨10.1089/cbr.2012.1292⟩
Journal articles inserm-02496646v1
Image document

Feasibility of the radioastatination of a monoclonal antibody with astatine-211 purified by wet extraction

Mickaël Bourgeois , François Guérard , Cyrille Alliot , Marie Mougin-Degraef , Holisoa Rajerison
Journal of Labelled Compounds and Radiopharmaceuticals, 2008, 51 (11), pp.379 - 383. ⟨10.1002/jlcr.1543⟩
Journal articles inserm-03290253v1
Image document

P-230 - Aryliodonium ylides as efficient precursors for astatine-211 labeling

Clémence Maingueneau , Marion Berdal , Romain Eychenne , Joëlle Gaschet , Michel Chérel
International symposium of radiopharmaceutical sciences, May 2022, Nantes, France
Conference papers inserm-03842392v1
Image document

P-169 - Influence of radiolysis on astatine-211 chemistry

Mohammad Ghalei , Parastoo Mahdi Khoshouei , Johan Vandenborre , François Guérard , Guillaume Blain
International symposium of radiopharmaceutical sciences, May 2022, Nantes, France
Conference papers inserm-03821660v1
Image document

O-66 - Preparation of 211At-labeled aromatic compounds from thioarylprecursors

Clémence Maingueneau , Romain Eychenne , Jean-François Gestin , François Guérard
International Symposium of radiopharmaceutical sciences, May 2022, Nantes, France
Conference papers inserm-03842544v1
Image document

Targeted alpha-therapy with 211At-anti-mCD138 mAb in a syngeneic murine Multiple Myeloma model : can repeated doses or fractionation protocol overpass single dose efficiency?

Sébastien Gouard , Séverine Marionneau-Lambot , Joëlle Gaschet , Sébastien Chouin , F. Haddad
33rd Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), European-Association-of-Nuclear-Medicine (EANM), Oct 2020, Virtuel, France. pp.S410-S411, ⟨10.1158/1078-0432.CCR-18-⟩
Conference papers inserm-03500243v1
Image document

Advances in the Radiolabeling of Antibodies with Astatine-211 : Toward Simplified Procedures and Improved Radiochemical Yields

François Guérard , Laurent Navarro , Marion Berdal , Ferid Haddad , Michel Chérel
TAT 11 INTERNATIONAL SYMPOSIUM, Apr 2019, OTTAWA, Canada. pp.S29
Conference papers inserm-02340810v1
Image document

Synthesis of precursors for 211At-labelling of anti-PSMA HuJ591 mAb and stability comparison after in vitro cellular internalization

Aurélia Roumesy , Sebastien Gouard , Laurent Navarro , Faustine Lelan , Ferid Haddad
ISRS 2019, May 2019, PEKIN, China. pp.S69-S70
Conference papers inserm-02340836v1