François-Xavier LEGRAND

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Publications

Publications

Improvement of the rheological properties and performance of liquid crystal emulsions: influence of oil addition and/or high-frequency ultrasound treatment

Amanda Caritá , Hichem Kichou , François-Xavier Legrand , Alexis Verger , Xavier Perse et al.
International Journal of Pharmaceutics, 2025, 682, pp.125934. ⟨10.1016/j.ijpharm.2025.125934⟩
Article dans une revue hal-05146411 v1

Insights into skin permeation enhancement using neoteric solvents: An ATR-FTIR study on human stratum corneum

Luc Augis , Sana Tfaili , Ali Tfayli , François-Xavier Legrand
Journal of Molecular Liquids, 2025, pp.128234. ⟨10.1016/j.molliq.2025.128234⟩
Article dans une revue hal-05193601 v1
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Clinical implementation of a paediatric 3D-printed combination of Sulfamethoxazole and Trimethoprim

Maxime Stoops , Bernard Do , Stéphanie Ramos , Bing Xun Tan , Nicholas Yong Sheng Chua et al.
International Journal of Pharmaceutics, 2025, 676, pp.125581. ⟨10.1016/j.ijpharm.2025.125581⟩
Article dans une revue hal-05038883 v1
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Repurposing chlorpromazine for anti-leukaemic therapy with the drug-in-cyclodextrin-in-liposome nanocarrier platform

Edvin Tang Gundersen , Zhiqiang Wang , Jan-Lukas Førde , Eric Larquet , Reidun Æsøy et al.
Carbohydrate Polymers, 2025, 358, pp.123478. ⟨10.1016/j.carbpol.2025.123478⟩
Article dans une revue hal-04981168 v1

Cocrystallization of Caffeine and Gallic Acid in Water and Methanol: Solid-State Landscape Using Ternary Diagrams

Dania Mellah-Hammouni , Yohann Cartigny , François-Xavier Legrand , Nicolas Guiblin , Bertrand Fournier et al.
Crystal Growth & Design, 2025, 25 (13), pp.4705-4712. ⟨10.1021/acs.cgd.5c00195⟩
Article dans une revue hal-05112047 v1

Porous ionic liquids based on biocompatible CD-MOFs

Cintia M Corrêa , Jocasta Avila , Tracy El Achkar , Pauline André , Shi-Minh Loo et al.
Chemical Communications, 2025, 61 (31), pp.5818-5821. ⟨10.1039/D5CC00489F⟩
Article dans une revue hal-05000112 v1

Liposomes loaded with daunorubicin and an emetine prodrug for improved selective cytotoxicity towards acute myeloid leukaemia cells

Ingeborg Nerbø Reiten , Francis Giraud , Tuva Torblå Augedal , Jan-Lukas Førde , Pascale Moreau et al.
International Journal of Pharmaceutics, 2025, pp.124989. ⟨10.1016/j.ijpharm.2024.124989⟩
Article dans une revue hal-04799525 v1
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A simple access to hexahydropyrimidine from 1,3-diamine: synthesis and solid-state characterization

Abdelkhalek Zerrouki , Béatrice Nicolaï , Mustapha Taleb , François-Xavier Legrand , Nicolas Guiblin et al.
Structural Chemistry, 2024, 35, pp.813-823. ⟨10.1007/s11224-023-02234-9⟩
Article dans une revue hal-04234932 v1

Development of a pediatric oral solution of ONC201 using nicotinamide to enhance solubility and stability

Maxime Annereau , Philippe-Henri Secretan , Marina Vignes , Stéphanie Ramos , Jacques Grill et al.
International Journal of Pharmaceutics, 2024, 667 (Part B), pp.124965. ⟨10.1016/j.ijpharm.2024.124965⟩
Article dans une revue hal-04878417 v1

Effects of Hydrophilic Natural Deep Eutectic Solvents on the Rheological, Textural, and Sensory Properties of Carboxymethylcellulose-Based Cosmetic Hydrogels

A Verger , H. Kichou , N. Huang , X Perse , I.-M. Ardeza et al.
ACS Sustainable Chemistry & Engineering, 2024, 12 (18), pp.7187-7199. ⟨10.1021/acssuschemeng.4c01866⟩
Article dans une revue hal-04570176 v1

Low melting mixtures: Neoteric green solvents for flavor formulation

Miriana Kfoury , François-Xavier Legrand , Steven Ruellan , Sophie Fourmentin
Journal of Molecular Liquids, 2024, 394, pp.123696. ⟨10.1016/j.molliq.2023.123696⟩
Article dans une revue hal-04316872 v1
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Development of nanoparticles based on amphiphilic cyclodextrins for the delivery of active substances

Luc Augis , Ingeborg Nerbø Reiten , Jan-Lukas Førde , Juan Casas-Solvas , Christina Sizun et al.
International Journal of Pharmaceutics, 2024, 651, pp.123723. ⟨10.1016/j.ijpharm.2023.123723⟩
Article dans une revue hal-04366812 v1
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Hydrophobic binary mixtures containing amphotericin B as lipophilic solutions for the treatment of cutaneous leishmaniasis

Luc Augis , Canh Hung Nguyen , Cécile Ciseran , András Wacha , Françoise Mercier-Nomé et al.
International Journal of Pharmaceutics, 2024, 662, pp.124486. ⟨10.1016/j.ijpharm.2024.124486⟩
Article dans une revue hal-04660063 v1

Fragmentation of DMPC Membranes by a Wedge-Shaped Amphiphilic Cyclodextrin into Bicellar-like Aggregates

Michel Roux , François-Xavier Legrand , Abed Bil , Véronique Bonnet , Florence Djedaini-Pilard
Journal of Physical Chemistry B, 2023, 127 (11), pp.2475-2487. ⟨10.1021/acs.jpcb.2c07331⟩
Article dans une revue hal-04032341 v1
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Human dendritic cell maturation induced by amorphous silica nanoparticles is Syk-dependent and triggered by lipid raft aggregation

Éléonore Guillet , Emilie Brun , Céline Ferard , Kévin Hardonnière , Myriam Nabhan et al.
Particle and Fibre Toxicology, 2023, 20 (1), pp.12. ⟨10.1186/s12989-023-00527-9⟩
Article dans une revue hal-04270376 v1

Molecular Mechanisms Involved in the Chemical Instability of ONC201 and Methods to Counter Its Degradation in Solution

Maxime Annereau , Marina Vignes , Lucas Denis , André Rieutord , François-Xavier Legrand et al.
Pharmaceutics, 2023, 15 (10), pp.2371. ⟨10.3390/pharmaceutics15102371⟩
Article dans une revue hal-04270374 v1
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New Cocrystallization Method: Non-photochemical Laser-Induced Nucleation of a Cocrystal of Caffeine–Gallic Acid in Water

Dania Mellah , Béatrice Nicolaï , Bertrand Fournier , Nada Bošnjaković-Pavlović , Francois-Xavier Legrand et al.
Crystal Growth & Design, 2022, 22 (10), pp.5982-5995. ⟨10.1021/acs.cgd.2c00624⟩
Article dans une revue hal-03788064 v1
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Breaking photoswitch activation depth limit using ionising radiation stimuli adapted to clinical application

Alban Guesdon Vennerie , P Couvreur , Fatoumia Ali , Frederic Pouzoulet , Christophe Roulin et al.
Nature Communications, 2022, 13, pp.4102. ⟨10.1038/s41467-022-30917-0⟩
Article dans une revue hal-03737235 v1
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Synthetic Amorphous Silica Nanoparticles Promote Human Dendritic Cell Maturation and CD4+ T-Lymphocyte Activation

Alexia Feray , Éléonore Guillet , Natacha Szely , Marie Hullo , François-Xavier Legrand et al.
Toxicological Sciences, 2022, 185 (1), pp.105-117. ⟨10.1093/toxsci/kfab120⟩
Article dans une revue hal-03604691 v1

Huge solubility increase of poorly water-soluble pharmaceuticals by sulfobutylether-β-cyclodextrin complexation in a low-melting mixture

Justine Petitprez , François-Xavier Legrand , Catherine Tams , J. Pipkin , Vince Antle et al.
Environmental Chemistry Letters, 2022, 20 (3), pp.1561-1568. ⟨10.1007/s10311-022-01415-y⟩
Article dans une revue hal-04242262 v1
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Discriminative and quantitative analysis of norepinephrine and epinephrine by Surface Enhanced Raman Spectroscopy with gold nanoparticle suspensions

Antoine Dowek , Marion Berge , Patrice Prognon , François-Xavier Legrand , Eric Larquet et al.
Analytical and Bioanalytical Chemistry, 2021, 414 (2), pp.1163-1176. ⟨10.1007/s00216-021-03743-4⟩
Article dans une revue hal-04664781 v1
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Tuning morphology of Pickering emulsions stabilised by biodegradable PLGA nanoparticles: How PLGA characteristics influence emulsion properties

Baptiste Robin , Claire Albert , Mohamed Beladjine , François-Xavier Legrand , Sandrine Geiger et al.
Journal of Colloid and Interface Science, 2021, 595, pp.202-211. ⟨10.1016/j.jcis.2021.03.061⟩
Article dans une revue hal-03209750 v1
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Optimization of experimental conditions by surface enhanced Raman Scattering (SERS) spectroscopy with gold nanoparticles suspensions

Marion Berge , Antoine Dowek , Patrice Prognon , François-Xavier Legrand , Ali Tfayli et al.
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy [1994-..], 2021, 268, pp.120628. ⟨10.1016/j.saa.2021.120628⟩
Article dans une revue hal-04270367 v1
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How to Address the Adjuvant Effects of Nanoparticles on the Immune System

Alexia Feray , Natacha Szely , Eléonore Guillet , Marie Hullo , François-Xavier Legrand et al.
Nanomaterials, 2020, 10 (3), pp.425. ⟨10.3390/nano10030425⟩
Article dans une revue hal-04049350 v1
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A mathematical approach to deal with nanoparticle polydispersity in surface enhanced Raman spectroscopy to quantify antineoplastic agents

Antoine Dowek , Laetitia Minh Mai Lê , Tom Rohmer , François-Xavier Legrand , Hynd Remita et al.
Talanta, 2020, 217, pp.121040. ⟨10.1016/j.talanta.2020.121040⟩
Article dans une revue hal-02557279 v1
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Cyclodextrin Complexation Studies as the First Step for Repurposing of Chlorpromazine

Zhiqiang Wang , David Landy , Christina Sizun , Christine Cézard , Audrey Solgadi et al.
International Journal of Pharmaceutics, 2020, 584, pp.119391. ⟨10.1016/j.ijpharm.2020.119391⟩
Article dans une revue hal-02885940 v1

The FcγRIIa–Syk Axis Controls Human Dendritic Cell Activation and T Cell Response Induced by Infliximab Aggregates

Myriam Nabhan , François-Xavier Legrand , Victor Le-Minh , Baptiste Robin , Rami Bechara et al.
Journal of Immunology, 2020, 205 (9), pp.2351-2361. ⟨10.4049/jimmunol.1901381⟩
Article dans une revue hal-04270355 v1

A mathematical approach to deal with nanoparticle polydispersity in surface enhanced Raman spectroscopy to quantify antineoplastic agents

Antoine Dowek , Laetitia Minh Mai Lê , Tom Rohmer , François-Xavier Legrand , Hynd Remita et al.
Talanta, 2020, 217, pp.121040. ⟨10.1016/j.talanta.2020.121040⟩
Article dans une revue hal-03437402 v1

A mathematical approach to deal with nanoparticle polydispersity in surface enhanced Raman spectroscopy to quantify antineoplastic agents

Antoine Dowek , Laetitia Minh Mai Lê , Tom Rohmer , François-Xavier Legrand , Hynd Remita et al.
Talanta, 2020, 217, pp.121040. ⟨10.1016/j.talanta.2020.121040⟩
Article dans une revue hal-04294318 v1
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Helically shaped cation receptor: design, synthesis, characterisation and first application to ion transport

Hamza Boufroura , Romain Plais , Salomé Poyer , Anne Gaucher , Jérôme Marrot et al.
RSC Advances, 2020, 10 (52), pp.31670-31679. ⟨10.1039/d0ra05519k⟩
Article dans une revue hal-02923986 v1
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New generation of supramolecular mixtures: Characterization and solubilization studies

Tracy El Achkar , Leila Moura , Tarek Moufawad , Steven Ruellan , Somenath Panda et al.
International Journal of Pharmaceutics, 2020, 584, pp.119443. ⟨10.1016/j.ijpharm.2020.119443⟩
Article dans une revue hal-03102809 v1
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Interaction of dequalinium chloride with phosphatidylcholine bilayers: A biophysical study with consequences on the development of lipid-based mitochondrial nanomedicines

Félix Sauvage , François-Xavier Legrand , Michel Roux , Ivan Rajkovic , Thomas M. Weiss et al.
Journal of Colloid and Interface Science, 2019, 537, pp.704--715. ⟨10.1016/j.jcis.2018.11.059⟩
Article dans une revue hal-02183686 v1
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Evaluation of zeta potential of nanomaterials by electrophoretic light scattering: Fast field reversal versus Slow field reversal modes

F. Varenne , J.-B. Coty , J Botton , F.-X. Legrand , H. Hillaireau et al.
Talanta, 2019, 205, pp.120062. ⟨10.1016/j.talanta.2019.06.062⟩
Article dans une revue hal-02983998 v1

Alumina nanoparticles size and crystalline phase impact on cytotoxic effect on alveolar epithelial cells after simple or HCl combined exposures

Alexandra Bourgois , David Crouzier , François-Xavier Legrand , Florent Raffin , Alexandre Boyard et al.
Toxicology in Vitro, 2019, 59, pp.135-149. ⟨10.1016/j.tiv.2019.04.016⟩
Article dans une revue hal-04270322 v1
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Self-Assembly of Amphiphilic Biotransesterified β-Cyclodextrins: Supramolecular Structure of Nanoparticles and Surface Properties

Jean-Luc Putaux , Christine Lancelon-Pin , François-Xavier Legrand , Marion Pastrello , Luc Choisnard et al.
Langmuir, 2017, 33 (32), pp.7917-7928. ⟨10.1021/acs.langmuir.7b01136⟩
Article dans une revue hal-02106206 v1

New nanoparticles obtained by co-assembly of amphiphilic cyclodextrins and nonlamellar single-chain lipids: Preparation and characterization

Cảnh Hưng Nguyễn , Jean-Luc Putaux , Gianluca Santoni , Sana Tfaili , Sophie Fourmentin et al.
International Journal of Pharmaceutics, 2017, 531 (2), pp.444-456. ⟨10.1016/j.ijpharm.2017.07.007⟩
Article dans une revue hal-02106211 v1

Size of monodispersed nanomaterials evaluated by dynamic light scattering: Protocol validated for measurements of 60 and 203nm diameter nanomaterials is now extended to 100 and 400nm.

F Varenne , J Botton , C Merlet , H Hillaireau , Fx Legrand et al.
International Journal of Pharmaceutics, 2016, ⟨10.1016/j.ijpharm.2016.10.016⟩
Article dans une revue hal-01437495 v1

Formulation and in vitro efficacy of liposomes containing the Hsp90 inhibitor 6BrCaQ in prostate cancer cells

Félix Sauvage , Silvia Franzè , Alexandre Bruneau , Mouad Alami , Stéphanie Denis et al.
International Journal of Pharmaceutics, 2016, 499 (1-2), pp.101-109. ⟨10.1016/j.ijpharm.2015.12.053⟩
Article dans une revue hal-04354282 v1
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Single-scan multidimensional NMR analysis of mixtures at sub-millimolar concentrations by using SABRE hyperpolarization

Valeria Daniele , François-Xavier Legrand , Patrick Berthault , Jean-Nicolas Dumez , Gaspard Huber
ChemPhysChem, 2015, 16, pp.3413-3417. ⟨10.1002/cphc.201500535⟩
Article dans une revue istex hal-01228706 v1

Standardization and validation of a protocol of size measurements by dynamic light scattering for monodispersed stable nanomaterial characterization

Varenne Fanny , Botton Jérémie , Merlet Claire , Beck-Broichsitter Moritz , Legrand François-Xavier et al.
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2015, ⟨10.1016/j.colsurfa.2015.08.043⟩
Article dans une revue hal-01437474 v1

From Solvents to Multifunctional Ingredients: Natural Deep Eutectic Solvents for Sustainable Cosmetic Emulsions

Divoux Laura , Alexis Verger , Thiery Emilie , Perse Xavier , Elsa Vrignaud et al.
4th International Meeting on Deep Eutectic Systems, DES Solutio & Nova University, Jun 2025, Lisboa, Portugal
Communication dans un congrès hal-05133306 v1

Co-crystallization of caffeine and gallic acid in water and methanol: Solid-state landscape using ternary diagrams

Dania Mellah , Yohann Cartigny , François-Xavier Legrand , Valérie Dupray , Bertrand Fournier et al.
Cristech 2024, Oct 2024, Angers, France
Communication dans un congrès hal-04746370 v1

NPLIN (Non-Photochemical Laser-Induced nucleation) of caffeine-gallic acid co-crystals in methanol »

Dania Mellah , Nada Bosnjakovic-Pavlovic , Nicolas Guiblin , Pascale Gemeiner , Vincent Boemare et al.
Cristallisation et Précipitation industrielles Cristal 10, Jun 2022, Lyon, France
Communication dans un congrès hal-04064611 v1

Supramolecular Eutectics as Solubilizers for Active Pharmaceutical Ingredients

Sarah El Masri , Steven Ruellan , François- Xavier Legrand , Sylvie Bouttier , G. Barratt et al.
SolvATE2020: Scientific Meeting of the GdR SolvATE, Nov 2020, Webinaire, France
Communication dans un congrès hal-04447157 v1
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Analyse de mélanges de solutés par couplage d'hyperpolarisation par parahydrogène et de séquences ultra-rapides

G. Huber , L Guduff , V Daniele , F-X Legrand , Patrick Berthault et al.
GERM, May 2019, Oléron, France
Communication dans un congrès cea-02329117 v1

Rayons X et rayonnements émis par les principaux radio-isotopes utilisés in vivo et in vitro

Nicolas Huang , François- Xavier Legrand
Peyrin E., Willand N., Didier P. (coord.). Chimie analytique - Chimie organique - Biophysique - L'enseignement en fiches, Elsevier Masson, pp.78-98, 2023, Objectif Internat Pharmacie, 9782294779862
Chapitre d'ouvrage hal-04353859 v1

Principes et application de la pression osmotique : osmolarité - osmolalité

François- Xavier Legrand , Christelle Wisniewski
Peyrin E., Willand N., Didier P. (coord.). Chimie analytique - Chimie organique - Biophysique - L'enseignement en fiches, Elsevier Masson, pp.127-131, 2023, Objectif Internat Pharmacie, 9782294779862
Chapitre d'ouvrage hal-04496690 v1
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Deep Eutectic Solvents for Innovative Pharmaceutical Formulations

François-Xavier Legrand , Canh-Hung Nguyen , Luc Augis , Sophie Fourmentin , Gillian Barratt
Deep eutectic solvents for innovative pharmaceutical formulations, 56, Springer, pp.41-102, 2021, Environmental Chemistry for a Sustainable World, 978-3-030-53068-6. ⟨10.1007/978-3-030-53069-3_2⟩
Chapitre d'ouvrage hal-03282900 v1