François-Xavier LEGRAND

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Publications

Hybrid GPP–hospital control strategy for semi-solid extrusion 3D printing of ONC201 chewable units in pediatric oncology

Stephanie Ramos , Marina Vignes , Philippe-Henri Secretan , François-Xavier Legrand , Maxime Annereau et al.

European Journal of Pharmaceutical Sciences, 2026, 216, pp.107326. ⟨10.1016/j.ejps.2025.107326⟩

Article dans une revue hal-05318721v1

Hospital-Compounded Birabresib Capsules for NUT Carcinoma: A Quality- and Risk-Based CMC Strategy

Maxime Annereau , François-Xavier Legrand , Maria Virginia Sánchez-Becerra , Stéphanie Ramos , Françoise Duperray et al.

Pharmaceutical Research, 2026, ⟨10.1007/s11095-026-04081-9⟩

Article dans une revue hal-05567574v1

Hospital 3D-printed cyclophosphamide printlets for paediatric patients

Malissa Boucida , Stéphanie Ramos , François-Xavier Legrand , Véronique Minard-Colin , Alexandre Michelet et al.

International Journal of Pharmaceutics, 2026, 696, pp.126824. ⟨10.1016/j.ijpharm.2026.126824⟩

Article dans une revue hal-05571619v1

Are hydrophilic deep eutectic solvents a potential vehicle for topical delivery of Amphotericin B against cutaneous leishmaniasis? An investigation of physicochemical properties, tolerability and antileishmanial efficacy

Cảnh Hưng Nguyễn , Catherine Cailleau , Natalie Fournier , Luc Augis , Françoise Mercier-Nomé et al.

International Journal of Pharmaceutics, 2026, 689, pp.126439. ⟨10.1016/j.ijpharm.2025.126439⟩

Article dans une revue hal-05397306v1

Liposomes loaded with daunorubicin and an emetine prodrug for improved selective cytotoxicity towards acute myeloid leukaemia cells

Ingeborg Nerbø Reiten , Francis Giraud , Tuva Torblå Augedal , Jan-Lukas Førde , Pascale Moreau et al.

International Journal of Pharmaceutics, 2025, pp.124989. ⟨10.1016/j.ijpharm.2024.124989⟩

Article dans une revue hal-04799525v1
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Clinical implementation of a paediatric 3D-printed combination of Sulfamethoxazole and Trimethoprim

Maxime Stoops , Bernard Do , Stéphanie Ramos , Bing Xun Tan , Nicholas Yong Sheng Chua et al.

International Journal of Pharmaceutics, 2025, 676, pp.125581. ⟨10.1016/j.ijpharm.2025.125581⟩

Article dans une revue hal-05038883v1
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Improvement of the rheological properties and performance of liquid crystal emulsions: influence of oil addition and/or high-frequency ultrasound treatment

Amanda Caritá , Hichem Kichou , François-Xavier Legrand , Alexis Verger , Xavier Perse et al.

International Journal of Pharmaceutics, 2025, 682, pp.125934. ⟨10.1016/j.ijpharm.2025.125934⟩

Article dans une revue hal-05146411v1
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Long-Circulating Liposomes Codelivering Amphotericin B and Retinoic Acid for Cutaneous Leishmaniasis Treatment

Thais Santos , Eduardo Lages , Tiago Ricotta , Leandro de Oliveira , Guilherme Ramos et al.

ACS Omega, 2025, 10 (41), pp.48514-48530. ⟨10.1021/acsomega.5c06156⟩

Article dans une revue hal-05302818v1

Insights into skin permeation enhancement using neoteric solvents: An ATR-FTIR study on human stratum corneum

Luc Augis , Sana Tfaili , François-Xavier Legrand , Ali Tfayli

Journal of Molecular Liquids, 2025, 437A, pp.128234. ⟨10.1016/j.molliq.2025.128234⟩

Article dans une revue hal-05193601v1

Cocrystallization of Caffeine and Gallic Acid in Water and Methanol: Solid-State Landscape Using Ternary Diagrams

Dania Mellah-Hammouni , Yohann Cartigny , François-Xavier Legrand , Nicolas Guiblin , Bertrand Fournier et al.

Crystal Growth & Design, 2025, 25 (13), pp.4705-4712. ⟨10.1021/acs.cgd.5c00195⟩

Article dans une revue hal-05112047v1
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Repurposing chlorpromazine for anti-leukaemic therapy with the drug-in-cyclodextrin-in-liposome nanocarrier platform

Edvin Tang Gundersen , Zhiqiang Wang , Jan-Lukas Førde , Eric Larquet , Reidun Æsøy et al.

Carbohydrate Polymers, 2025, 358, pp.123478. ⟨10.1016/j.carbpol.2025.123478⟩

Article dans une revue hal-04981168v1

Porous ionic liquids based on biocompatible CD-MOFs

Cintia M Corrêa , Jocasta Avila , Tracy El Achkar , Pauline André , Shi-Minh Loo et al.

Chemical Communications, 2025, 61 (31), pp.5818-5821. ⟨10.1039/D5CC00489F⟩

Article dans une revue hal-05000112v1
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Effects of Hydrophilic Natural Deep Eutectic Solvents on the Rheological, Textural, and Sensory Properties of Carboxymethylcellulose-Based Cosmetic Hydrogels

A Verger , Hichem Kichou , Nicolas Huang , Xavier Perse , I.-M. Ardeza et al.

ACS Sustainable Chemistry & Engineering, 2024, 12 (18), pp.7187-7199. ⟨10.1021/acssuschemeng.4c01866⟩

Article dans une revue hal-04570176v1
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A simple access to hexahydropyrimidine from 1,3-diamine: synthesis and solid-state characterization

Abdelkhalek Zerrouki , Béatrice Nicolaï , Mustapha Taleb , François-Xavier Legrand , Nicolas Guiblin et al.

Structural Chemistry, 2024, 35, pp.813-823. ⟨10.1007/s11224-023-02234-9⟩

Article dans une revue hal-04234932v1

Development of a pediatric oral solution of ONC201 using nicotinamide to enhance solubility and stability

Maxime Annereau , Philippe-Henri Secretan , Marina Vignes , Stéphanie Ramos , Jacques Grill et al.

International Journal of Pharmaceutics, 2024, 667 (Part B), pp.124965. ⟨10.1016/j.ijpharm.2024.124965⟩

Article dans une revue hal-04878417v1

Low melting mixtures: Neoteric green solvents for flavor formulation

Miriana Kfoury , François-Xavier Legrand , Steven Ruellan , Sophie Fourmentin

Journal of Molecular Liquids, 2024, 394, pp.123696. ⟨10.1016/j.molliq.2023.123696⟩

Article dans une revue hal-04316872v1
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Development of nanoparticles based on amphiphilic cyclodextrins for the delivery of active substances

Luc Augis , Ingeborg Nerbø Reiten , Jan-Lukas Førde , Juan Casas-Solvas , Christina Sizun et al.

International Journal of Pharmaceutics, 2024, 651, pp.123723. ⟨10.1016/j.ijpharm.2023.123723⟩

Article dans une revue hal-04366812v1
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Hydrophobic binary mixtures containing amphotericin B as lipophilic solutions for the treatment of cutaneous leishmaniasis

Luc Augis , Canh Hung Nguyen , Cécile Ciseran , András Wacha , Françoise Mercier-Nomé et al.

International Journal of Pharmaceutics, 2024, 662, pp.124486. ⟨10.1016/j.ijpharm.2024.124486⟩

Article dans une revue hal-04660063v1

Fragmentation of DMPC Membranes by a Wedge-Shaped Amphiphilic Cyclodextrin into Bicellar-like Aggregates

Michel Roux , François-Xavier Legrand , Abed Bil , Véronique Bonnet , Florence Djedaini-Pilard

Journal of Physical Chemistry B, 2023, 127 (11), pp.2475-2487. ⟨10.1021/acs.jpcb.2c07331⟩

Article dans une revue hal-04032341v1
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Human dendritic cell maturation induced by amorphous silica nanoparticles is Syk-dependent and triggered by lipid raft aggregation

Éléonore Guillet , Emilie Brun , Céline Ferard , Kévin Hardonnière , Myriam Nabhan et al.

Particle and Fibre Toxicology, 2023, 20 (1), pp.12. ⟨10.1186/s12989-023-00527-9⟩

Article dans une revue hal-04270376v1

Molecular Mechanisms Involved in the Chemical Instability of ONC201 and Methods to Counter Its Degradation in Solution

Maxime Annereau , Marina Vignes , Lucas Denis , André Rieutord , François-Xavier Legrand et al.

Pharmaceutics, 2023, 15 (10), pp.2371. ⟨10.3390/pharmaceutics15102371⟩

Article dans une revue hal-04270374v1

Huge solubility increase of poorly water-soluble pharmaceuticals by sulfobutylether-β-cyclodextrin complexation in a low-melting mixture

Justine Petitprez , François-Xavier Legrand , Catherine Tams , J. Pipkin , Vince Antle et al.

Environmental Chemistry Letters, 2022, 20 (3), pp.1561-1568. ⟨10.1007/s10311-022-01415-y⟩

Article dans une revue hal-04242262v1
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New Cocrystallization Method: Non-photochemical Laser-Induced Nucleation of a Cocrystal of Caffeine–Gallic Acid in Water

Dania Mellah , Béatrice Nicolaï , Bertrand Fournier , Nada Bošnjaković-Pavlović , Francois-Xavier Legrand et al.

Crystal Growth & Design, 2022, 22 (10), pp.5982-5995. ⟨10.1021/acs.cgd.2c00624⟩

Article dans une revue hal-03788064v1
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Breaking photoswitch activation depth limit using ionising radiation stimuli adapted to clinical application

Alban Guesdon Vennerie , P Couvreur , Fatoumia Ali , Frederic Pouzoulet , Christophe Roulin et al.

Nature Communications, 2022, 13, pp.4102. ⟨10.1038/s41467-022-30917-0⟩

Article dans une revue hal-03737235v1
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Synthetic Amorphous Silica Nanoparticles Promote Human Dendritic Cell Maturation and CD4+ T-Lymphocyte Activation

Alexia Feray , Éléonore Guillet , Natacha Szely , Marie Hullo , François-Xavier Legrand et al.

Toxicological Sciences, 2022, 185 (1), pp.105-117. ⟨10.1093/toxsci/kfab120⟩

Article dans une revue hal-03604691v1
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Discriminative and quantitative analysis of norepinephrine and epinephrine by Surface Enhanced Raman Spectroscopy with gold nanoparticle suspensions

Antoine Dowek , Marion Berge , Patrice Prognon , François-Xavier Legrand , Eric Larquet et al.

Analytical and Bioanalytical Chemistry, 2021, 414 (2), pp.1163-1176. ⟨10.1007/s00216-021-03743-4⟩

Article dans une revue hal-04664781v1
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Tuning morphology of Pickering emulsions stabilised by biodegradable PLGA nanoparticles: How PLGA characteristics influence emulsion properties

Baptiste Robin , Claire Albert , Mohamed Beladjine , François-Xavier Legrand , Sandrine Geiger et al.

Journal of Colloid and Interface Science, 2021, 595, pp.202-211. ⟨10.1016/j.jcis.2021.03.061⟩

Article dans une revue hal-03209750v1
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Optimization of experimental conditions by surface enhanced Raman Scattering (SERS) spectroscopy with gold nanoparticles suspensions

Marion Berge , Antoine Dowek , Patrice Prognon , François-Xavier Legrand , Ali Tfayli et al.

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy [1994-..], 2021, 268, pp.120628. ⟨10.1016/j.saa.2021.120628⟩

Article dans une revue hal-04270367v1
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New generation of supramolecular mixtures: Characterization and solubilization studies

Tracy El Achkar , Leila Moura , Tarek Moufawad , Steven Ruellan , Somenath Panda et al.

International Journal of Pharmaceutics, 2020, Part of special issue Special Issue in Honor of Professor Thorsteinn Loftsson on the Occasion of His 70th Birthday, 584, pp.119443. ⟨10.1016/j.ijpharm.2020.119443⟩

Article dans une revue hal-03102809v1
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How to Address the Adjuvant Effects of Nanoparticles on the Immune System

Alexia Feray , Natacha Szely , Eléonore Guillet , Marie Hullo , François-Xavier Legrand et al.

Nanomaterials, 2020, 10 (3), pp.425. ⟨10.3390/nano10030425⟩

Article dans une revue hal-04049350v1
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A mathematical approach to deal with nanoparticle polydispersity in surface enhanced Raman spectroscopy to quantify antineoplastic agents

Antoine Dowek , Laetitia Minh Mai Lê , Tom Rohmer , François-Xavier Legrand , Hynd Remita et al.

Talanta, 2020, 217, pp.121040. ⟨10.1016/j.talanta.2020.121040⟩

Article dans une revue hal-02557279v1

The FcγRIIa–Syk Axis Controls Human Dendritic Cell Activation and T Cell Response Induced by Infliximab Aggregates

Myriam Nabhan , François-Xavier Legrand , Victor Le-Minh , Baptiste Robin , Rami Bechara et al.

Journal of Immunology, 2020, 205 (9), pp.2351-2361. ⟨10.4049/jimmunol.1901381⟩

Article dans une revue hal-04270355v1
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Cyclodextrin Complexation Studies as the First Step for Repurposing of Chlorpromazine

Zhiqiang Wang , David Landy , Christina Sizun , Christine Cézard , Audrey Solgadi et al.

International Journal of Pharmaceutics, 2020, 584, pp.119391. ⟨10.1016/j.ijpharm.2020.119391⟩

Article dans une revue hal-02885940v1

A mathematical approach to deal with nanoparticle polydispersity in surface enhanced Raman spectroscopy to quantify antineoplastic agents

Antoine Dowek , Laetitia Minh Mai Lê , Tom Rohmer , François-Xavier Legrand , Hynd Remita et al.

Talanta, 2020, 217, pp.121040. ⟨10.1016/j.talanta.2020.121040⟩

Article dans une revue hal-04294318v1

A mathematical approach to deal with nanoparticle polydispersity in surface enhanced Raman spectroscopy to quantify antineoplastic agents

Antoine Dowek , Laetitia Minh Mai Lê , Tom Rohmer , François-Xavier Legrand , Hynd Remita et al.

Talanta, 2020, 217, pp.121040. ⟨10.1016/j.talanta.2020.121040⟩

Article dans une revue hal-03437402v1
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Helically shaped cation receptor: design, synthesis, characterisation and first application to ion transport

Hamza Boufroura , Romain Plais , Salomé Poyer , Anne Gaucher , Jérôme Marrot et al.

RSC Advances, 2020, 10 (52), pp.31670-31679. ⟨10.1039/d0ra05519k⟩

Article dans une revue hal-02923986v1
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Interaction of dequalinium chloride with phosphatidylcholine bilayers: A biophysical study with consequences on the development of lipid-based mitochondrial nanomedicines

Félix Sauvage , François-Xavier Legrand , Michel Roux , Ivan Rajkovic , Thomas M. Weiss et al.

Journal of Colloid and Interface Science, 2019, 537, pp.704--715. ⟨10.1016/j.jcis.2018.11.059⟩

Article dans une revue hal-02183686v1
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Evaluation of zeta potential of nanomaterials by electrophoretic light scattering: Fast field reversal versus Slow field reversal modes

F. Varenne , J.-B. Coty , J Botton , F.-X. Legrand , H. Hillaireau et al.

Talanta, 2019, 205, pp.120062. ⟨10.1016/j.talanta.2019.06.062⟩

Article dans une revue hal-02983998v1

Alumina nanoparticles size and crystalline phase impact on cytotoxic effect on alveolar epithelial cells after simple or HCl combined exposures

Alexandra Bourgois , David Crouzier , François-Xavier Legrand , Florent Raffin , Alexandre Boyard et al.

Toxicology in Vitro, 2019, 59, pp.135-149. ⟨10.1016/j.tiv.2019.04.016⟩

Article dans une revue hal-04270322v1

New nanoparticles obtained by co-assembly of amphiphilic cyclodextrins and nonlamellar single-chain lipids: Preparation and characterization

Cảnh Hưng Nguyễn , Jean-Luc Putaux , Gianluca Santoni , Sana Tfaili , Sophie Fourmentin et al.

International Journal of Pharmaceutics, 2017, 531 (2), pp.444-456. ⟨10.1016/j.ijpharm.2017.07.007⟩

Article dans une revue hal-02106211v1
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Self-Assembly of Amphiphilic Biotransesterified β-Cyclodextrins: Supramolecular Structure of Nanoparticles and Surface Properties

Jean-Luc Putaux , Christine Lancelon-Pin , François-Xavier Legrand , Marion Pastrello , Luc Choisnard et al.

Langmuir, 2017, 33 (32), pp.7917-7928. ⟨10.1021/acs.langmuir.7b01136⟩

Article dans une revue hal-02106206v1

Size of monodispersed nanomaterials evaluated by dynamic light scattering: Protocol validated for measurements of 60 and 203nm diameter nanomaterials is now extended to 100 and 400nm.

F Varenne , J Botton , C Merlet , H Hillaireau , Fx Legrand et al.

International Journal of Pharmaceutics, 2016, ⟨10.1016/j.ijpharm.2016.10.016⟩

Article dans une revue hal-01437495v1

Formulation and in vitro efficacy of liposomes containing the Hsp90 inhibitor 6BrCaQ in prostate cancer cells

Félix Sauvage , Silvia Franzè , Alexandre Bruneau , Mouad Alami , Stéphanie Denis et al.

International Journal of Pharmaceutics, 2016, 499 (1-2), pp.101-109. ⟨10.1016/j.ijpharm.2015.12.053⟩

Article dans une revue istex hal-04354282v1
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Single-scan multidimensional NMR analysis of mixtures at sub-millimolar concentrations by using SABRE hyperpolarization

Valeria Daniele , François-Xavier Legrand , Patrick Berthault , Jean-Nicolas Dumez , Gaspard Huber

ChemPhysChem, 2015, 16, pp.3413-3417. ⟨10.1002/cphc.201500535⟩

Article dans une revue istex hal-01228706v1

Standardization and validation of a protocol of size measurements by dynamic light scattering for monodispersed stable nanomaterial characterization

Varenne Fanny , Botton Jérémie , Merlet Claire , Beck-Broichsitter Moritz , Legrand François-Xavier et al.

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2015, ⟨10.1016/j.colsurfa.2015.08.043⟩

Article dans une revue hal-01437474v1

From Solvents to Multifunctional Ingredients: Natural Deep Eutectic Solvents for Sustainable Cosmetic Emulsions

Divoux Laura , Alexis Verger , Thiery Emilie , Perse Xavier , Elsa Vrignaud et al.

4th International Meeting on Deep Eutectic Systems, DES Solutio & Nova University, Jun 2025, Lisboa, Portugal

Communication dans un congrès hal-05133306v1

From nature to topical medications: current challenges and place of natural eutectic matrices

Emilie Munnier , Laura Divoux , Alexis Verger , Elsa Vrignaud , Ecaterina Gore et al.

Skin Forum 2025 annual meeting, APV; Skin Forum, Jun 2025, Berlin, Germany

Communication dans un congrès hal-05313764v1

Impact of natural eutectic matrices on the stability and properties of skincare products

Émilie Munnier , Alexis Verger , Roxane Grard , Xavier Perse , Charlotte Pradel et al.

International Congress Unité de Recherche en Chimie Organique et Macromoléculaire (URCOM25), Université Le Havre Normandie, May 2024, Le Havre, France

Communication dans un congrès hal-05578259v1

Co-crystallization of caffeine and gallic acid in water and methanol: Solid-state landscape using ternary diagrams

Dania Mellah , Yohann Cartigny , François-Xavier Legrand , Valérie Dupray , Bertrand Fournier et al.

Cristech 2024, Oct 2024, Angers, France

Communication dans un congrès hal-04746370v1

NPLIN (Non-Photochemical Laser-Induced nucleation) of caffeine-gallic acid co-crystals in methanol »

Dania Mellah , Nada Bosnjakovic-Pavlovic , Nicolas Guiblin , Pascale Gemeiner , Vincent Boemare et al.

Cristallisation et Précipitation industrielles Cristal 10, Jun 2022, Lyon, France

Communication dans un congrès hal-04064611v1

Supramolecular Eutectics as Solubilizers for Active Pharmaceutical Ingredients

Sarah El Masri , Steven Ruellan , François- Xavier Legrand , Sylvie Bouttier , G. Barratt et al.

SolvATE2020: Scientific Meeting of the GdR SolvATE, Nov 2020, Webinaire, France

Communication dans un congrès hal-04447157v1
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Analyse de mélanges de solutés par couplage d'hyperpolarisation par parahydrogène et de séquences ultra-rapides

G. Huber , L Guduff , V Daniele , F-X Legrand , Patrick Berthault et al.

GERM, May 2019, Oléron, France

Communication dans un congrès cea-02329117v1

Rayons X et rayonnements émis par les principaux radio-isotopes utilisés in vivo et in vitro

Nicolas Huang , François- Xavier Legrand

Peyrin E., Willand N., Didier P. (coord.). Chimie analytique - Chimie organique - Biophysique - L'enseignement en fiches, Elsevier Masson, pp.78-98, 2023, Objectif Internat Pharmacie, 9782294779862

Chapitre d'ouvrage hal-04353859v1

Principes et application de la pression osmotique : osmolarité - osmolalité

François- Xavier Legrand , Christelle Wisniewski

Peyrin E., Willand N., Didier P. (coord.). Chimie analytique - Chimie organique - Biophysique - L'enseignement en fiches, Elsevier Masson, pp.127-131, 2023, Objectif Internat Pharmacie, 9782294779862

Chapitre d'ouvrage hal-04496690v1
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Deep Eutectic Solvents for Innovative Pharmaceutical Formulations

François-Xavier Legrand , Canh-Hung Nguyen , Luc Augis , Sophie Fourmentin , Gillian Barratt

Deep eutectic solvents for innovative pharmaceutical formulations, 56, Springer, pp.41-102, 2021, Environmental Chemistry for a Sustainable World, 978-3-030-53068-6. ⟨10.1007/978-3-030-53069-3_2⟩

Chapitre d'ouvrage hal-03282900v1