Francoise Debart

98
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Publications

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Synthesis and in vitro inhibitory activity of N-arylsulfonamide adenosine analogues designed to target SARS-CoV-2 nsp14 N7-methyltransferase

Marcel Hausdorff , Adrien Delpal , Hugo Machin , Amina Tahir , Jim Zoladek et al.

Bioorganic Chemistry, 2025, 166, pp.109104. ⟨10.1016/j.bioorg.2025.109104⟩

Article dans une revue hal-05371098v1
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5′-cap RNA/SAM mimetic conjugates as bisubstrate inhibitors of viral RNA cap 2′-O-methyltransferases

Rostom Ahmed‐belkacem , Priscila Sutto-Ortiz , Adrien Delpal , Joris Troussier , Bruno Canard et al.

Bioorganic Chemistry, 2024, 143, pp.107035. ⟨10.1016/j.bioorg.2023.107035⟩

Article dans une revue hal-04456996v1
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Accelerated, high-quality photolithographic synthesis of RNA microarrays in situ

Tadija Kekić , Nemanja Milisavljević , Joris Troussier , Amina Tahir , Françoise Debart et al.

Science Advances , 2024, 10 (31), ⟨10.1126/sciadv.ado6762⟩

Article dans une revue hal-04741717v1
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N-arylsulfonamide-based adenosine analogues to target RNA cap N7-methyltransferase nsp14 of SARS-CoV-2

Rostom Ahmed‐belkacem , Joris Troussier , Adrien Delpal , Bruno Canard , Jean-Jacques Vasseur et al.

RSC Medicinal Chemistry, 2024, ⟨10.1039/d3md00737e⟩

Article dans une revue hal-04426066v1
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Synthesis of acyclic analogues of adenosine sulfonamides and their activity against RNA cap guanine N 7-methyltransferase of SARS-CoV-2

Rostom Ahmed‐belkacem , Adrien Delpal , Bruno Canard , Jean-Jacques Vasseur , Etienne Decroly et al.

New Journal of Chemistry, 2024, 143, pp.107035. ⟨10.1039/D4NJ02481H⟩

Article dans une revue hal-04741812v1
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Access to High‐Purity 7m G‐cap RNA in Substantial Quantities by a Convenient All‐Chemical Solid‐Phase Method

Mathieu Noël , Theo Guez , Yann Thillier , Jean‐jacques Vasseur , Françoise Debart

ChemBioChem, 2023, 24 (2), pp.756-765. ⟨10.1002/cbic.202300544⟩

Article dans une revue hal-04235335v1
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AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5

Mikael Feracci , Cécilia Eydoux , Véronique Fattorini , Lea Lo Bello , Pierre Gauffre et al.

Antiviral Research, 2023, 212, pp.105574. ⟨10.1016/j.antiviral.2023.105574⟩

Article dans une revue hal-04159074v1
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Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases

Marcel Hausdorff , Adrien Delpal , Sarah Barelier , Laura Nicollet , Bruno Canard et al.

European Journal of Medicinal Chemistry, In press, ⟨10.1016/j.ejmech.2023.115474⟩

Article dans une revue hal-04095336v1
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Serendipitous Synthesis of 5-Hydroxyuridine from 2',3'-O-isopropylidene N4-Acetylcytidine by Hypervalent Iodine(III)-Mediated Reaction

Mary Anne Maverick , Mathieu Noël , Jean-Jacques Vasseur , Carine Baraguey , Françoise Debart et al.

SYNLETT, 2023, ⟨10.1055/a-2174-2554⟩

Article dans une revue hal-04235363v1
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Direct Access to Unique C‐5’‐Acyl Modified Nucleosides through Liebeskind–Srogl Cross‐Coupling Reaction

Mary Anne Maverick , Marie Gaillard , Jean Jacques Vasseur , Françoise Debart , Michael Smietana

European Journal of Organic Chemistry, 2022, 2022 (21), ⟨10.1002/ejoc.202101061⟩

Article dans une revue hal-03737774v1
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A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome

Ashleigh Shannon , Bhawna Sama , Pierre Gauffre , Théo Guez , Françoise Debart et al.

Nucleic Acids Research, 2022, 50 (19), pp.11186-11198. ⟨10.1093/nar/gkac876⟩

Article dans une revue hal-03937366v1
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Importance of RNA length for in vitro encapsidation by the nucleoprotein of human respiratory syncytial virus

Lorène Gonnin , Charles-Adrien Richard , Irina Gutsche , Didier Chevret , Joris Troussier et al.

Journal of Biological Chemistry, 2022, 298 (9), pp.102337. ⟨10.1016/j.jbc.2022.102337⟩

Article dans une revue hal-03797501v2
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Inhibiteurs bisubstrats de méthyltransférases virales

Rostom Ahmed‐belkacem , J.J. Vasseur , Francoise Debart

L'Actualité Chimique, 2022

Article dans une revue hal-03721682v1
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Facile access to 4′-( N -acylsulfonamide) modified nucleosides and evaluation of their inhibitory activity against SARS-CoV-2 RNA cap N 7-guanine-methyltransferase nsp14

Romain Amador , Adrien Delpal , Bruno Canard , Jean-Jacques Vasseur , Etienne Decroly et al.

Organic & Biomolecular Chemistry, 2022, 20 (38), pp.7582-7586. ⟨10.1039/d2ob01569b⟩

Article dans une revue hal-03801035v1
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Potent Inhibition of SARS-CoV-2 nsp14 N 7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues

Rostom Ahmed‐belkacem , Marcel Hausdorff , Adrien Delpal , Priscila Sutto-Ortiz , Agathe M G Colmant et al.

Journal of Medicinal Chemistry, 2022, 65 (8), pp.6231-6249. ⟨10.1021/acs.jmedchem.2c00120⟩

Article dans une revue hal-03721688v1
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Bisubstrate Strategies to Target Methyltransferases

Rostom Ahmed‐belkacem , Françoise Debart , Jean‐jacques Vasseur

European Journal of Organic Chemistry, 2022, 2022 (21), pp.e202101481. ⟨10.1002/ejoc.202101481⟩

Article dans une revue hal-03727961v1
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Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect

Priscila El Kazzi , Nadia Rabah , Célia Chamontin , Lina Poulain , François Ferron et al.

Nucleic Acids Research, 2022, ⟨10.1093/nar/gkac996⟩

Article dans une revue hal-03860650v1
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FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell

Sébastien Relier , Julie Ripoll , Hélène Guillorit , Amandine Amalric , Cyrinne Achour et al.

Nature Communications, 2021, 12 (1), pp.1716. ⟨10.1038/s41467-021-21758-4⟩

Article dans une revue hal-03178788v2
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The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2’-O-methylation

Priscila Sutto-Ortiz , Sergey Tcherniuk , Nina Ysebaert , Pravien Abeywickrema , Mathieu Noël et al.

PLoS Pathogens, 2021, 17 (5), pp.1-20. ⟨10.1371/journal.ppat.1009562⟩

Article dans une revue hal-03282037v1
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First insights into the structural features of Ebola virus methyltransferase activities

Coralie Valle , Baptiste Martin , François Ferron , Véronique Roig-Zamboni , Aline Desmyter et al.

Nucleic Acids Research, 2021, 49 (3), pp.1737 - 1748. ⟨10.1093/nar/gkaa1276⟩

Article dans une revue hal-03334409v1
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Conjugation of Doxorubicin to siRNA Through Disulfide-based Self-immolative Linkers

Florian Gauthier , Jean-Rémi Bertrand , Jean-Jacques Vasseur , Christelle Dupouy , Francoise Debart

Molecules, 2020, 25 (11), pp.2714. ⟨10.3390/molecules25112714⟩

Article dans une revue hal-02991729v1
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Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase

Rostom Ahmed‐belkacem , Priscila Sutto-Ortiz , Mathis Guiraud , Bruno Canard , Jean-Jacques Vasseur et al.

European Journal of Medicinal Chemistry, 2020, 201, pp.112557. ⟨10.1016/j.ejmech.2020.112557⟩

Article dans une revue hal-02890580v1
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The C-Terminal Domain of the Sudan Ebolavirus L Protein Is Essential for RNA Binding and Methylation

Coralie Valle , Baptiste Martin , Francoise Debart , Jean-Jacques Vasseur , Isabelle Imbert et al.

Journal of Virology, 2020, 94 (12), pp.e00520-20. ⟨10.1128/JVI.00520-20⟩

Article dans une revue hal-02890587v1
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FTO controls reversible m6Am RNA methylation during snRNA biogenesis

Jan Mauer , Miriam Sindelar , Vladimir Despic , Théo Guez , Benjamin Hawley et al.

Nature Chemical Biology, 2019, 15 (4), pp.340-347. ⟨10.1038/s41589-019-0231-8⟩

Article dans une revue hal-02197144v1
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Conjugation of Small Molecules to RNA Using a Reducible Disulfide Linker Attached at the 2′-OH Position through a Carbamate Function

Florian Gauthier , Astrid Malher , Jean-Jacques Vasseur , Christelle Dupouy , Françoise Debart

European Journal of Organic Chemistry, 2019, 2019 (33), pp.5636-5645. ⟨10.1002/ejoc.201900740⟩

Article dans une revue hal-02307249v1
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Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome

Konstantinos Boulias , Diana Toczydłowska-Socha , Ben Hawley , Noa Liberman , Ken Takashima et al.

Molecular Cell, 2019, ⟨10.1016/j.molcel.2019.06.006⟩

Article dans une revue hal-02197217v1
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Synthesis of Adenine Dinucleosides 2′,5′-Bridged by Sulfur-Containing Linkers as Bisubstrate SAM Analogues for Viral RNA 2′- O -Methyltransferases

Rostom Ahmed‐belkacem , Priscila Sutto Ortiz , Etienne Decroly , Jean-Jacques Vasseur , Françoise Debart

European Journal of Organic Chemistry, 2019, 2019 (38), ⟨10.1002/ejoc.201901120⟩

Article dans une revue hal-02992283v1
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Combining Chemical Synthesis and Enzymatic Methylation to Access Short RNAs with Various 5′ Caps

Nils Muthmann , Théo Guez , Jean-Jacques Vasseur , Samie Jaffrey , Françoise Debart et al.

ChemBioChem, 2019, ⟨10.1002/cbic.201900037⟩

Article dans une revue hal-02197219v1

Gymnotic delivery and gene silencing activity of reduction-responsive siRNAs bearing lipophilic disulfide-containing modifications at 2′-position

Florian Gauthier , Sandra Claveau , Jean-Rémi Bertrand , Jean-Jacques Vasseur , Christelle Dupouy et al.

Bioorganic and Medicinal Chemistry, 2018, 26 (16), pp.4635-4643. ⟨10.1016/j.bmc.2018.07.033⟩

Article dans une revue hal-02197153v1
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The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure

Baptiste Martin , Bruno Coutard , Théo Guez , Guido Paesen , Bruno Canard et al.

Nucleic Acids Research, 2018, 46 (15), pp.7902-7912. ⟨10.1093/nar/gky637⟩

Article dans une revue inserm-02416986v1
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Ebola virus L protein harbors a new enzymatic activity involved in the internal methylation of RNAs

Baptiste Martin , Coralie Valle , Bruno Coutard , Bruno Canard , Françoise Debart et al.

Médecine/Sciences, 2018, 34 (11), pp.919-921. ⟨10.1051/medsci/2018230⟩

Article dans une revue hal-02094423v1
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Stimuli-responsive oligonucleotides in prodrug-based approaches for gene silencing

Françoise Debart , Christelle Dupouy , Jean-Jacques Vasseur

Beilstein Journal of Organic Chemistry, 2018, 14 (26), pp.436-469. ⟨10.3762/bjoc.14.32⟩

Article dans une revue hal-02197155v1
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La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region

Lucas Philippe , Jean-Jacques Vasseur , Françoise Debart , Carson Thoreen

Nucleic Acids Research, 2018, 46 (3), pp.1457-1469. ⟨10.1093/nar/gkx1237⟩

Article dans une revue hal-02197161v1

A 2′,2′-disulfide-bridged dinucleotide conformationally locks RNA hairpins

Florian Gauthier , Frédéric Beltran , Annabelle Biscans , Françoise Debart , Christelle Dupouy et al.

Organic & Biomolecular Chemistry, 2018, 16 (17), pp.3181-3188. ⟨10.1039/c8ob00328a⟩

Article dans une revue hal-02197157v1
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Binding of the Methyl Donor S -Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2′- O -Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10

Wahiba Aouadi , Alexandre Blanjoie , Jean-Jacques Vasseur , Françoise Debart , Bruno Canard et al.

Journal of Virology, 2017, 91 (5), pp.1103-1119. ⟨10.1128/JVI.02217-16⟩

Article dans une revue hal-01802788v1
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Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay

Wahiba Aouadi , C Ecilia Eydoux , Bruno Coutard , Baptiste Martin , Françoise Debart et al.

Antiviral Research, 2017, 144, pp.330-339. ⟨10.1016/j.antiviral.2017.06.021⟩

Article dans une revue hal-02349530v1
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Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress

Ana Tamarkin-Ben-Harush , Jean-Jacques Vasseur , Françoise Debart , Igor Ulitsky , Rivka Dikstein

eLife, 2017, 6, ⟨10.7554/eLife.21907⟩

Article dans une revue hal-02197213v1
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Reversible methylation of m6Am in the 5′ cap controls mRNA stability

Jan Mauer , Xiaobing Luo , Alexandre Blanjoie , Xinfu Jiao , Anya V Grozhik et al.

Nature, 2017, 541 (7637), pp.371-375. ⟨10.1038/nature21022⟩

Article dans une revue hal-02197215v1
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Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives

Bruno Coutard , Karine Barral , Julie Lichiere , Barbara Selisko , Baptiste Martin et al.

Journal of Virology, 2017, 91 (5), pp.2202-2218. ⟨10.1128/JVI.02202-16⟩

Article dans une revue hal-01802793v1

A versatile post-synthetic method on a solid support for the synthesis of RNA containing reduction-responsive modifications

Annabelle Biscans , Sonia Rouanet , Jean-Jacques Vasseur , Christelle Dupouy , Françoise Debart

Organic & Biomolecular Chemistry, 2016, 14 (29), pp.7010-7017. ⟨10.1039/c6ob01272h⟩

Article dans une revue hal-02197255v1

Lipophilic 2′- O -Acetal Ester RNAs: Synthesis, Thermal Duplex Stability, Nuclease Resistance, Cellular Uptake, and siRNA Activity after Spontaneous Naked Delivery

Annabelle Biscans , Jean-Rémi Bertrand , Josephine Dubois , Jacqueline Rüger , Jean-Jacques Vasseur et al.

ChemBioChem, 2016, 17 (21), pp.2054-2062. ⟨10.1002/cbic.201600317⟩

Article dans une revue istex hal-02197248v1

mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research

Changqing Li , Jaime Guillen , Nadia Rabah , Alexandre Blanjoie , Francoise Debart et al.

Journal of Virology, 2015, 89 (16), pp.8292-8303. ⟨10.1128/JVI.00599-15⟩

Article dans une revue hal-01439035v1
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X-ray structure and activities of an essential Mononegavirales L-protein domain

Guido C. Paesen , Axelle Collet , Corinne Sallamand , Francoise Debart , Jean-Jacques Vasseur et al.

Nature Communications, 2015, 6, pp.8749. ⟨10.1038/ncomms9749⟩

Article dans une revue hal-01439027v1

Solid-Phase Synthesis of Oligonucleotide 5′-(α- P -Thio)triphosphates and 5′-(α- P -Thio)(β,γ-methylene)triphosphates

Yann Thillier , Corinne Sallamand , Carine Baraguey , Jean-Jacques Vasseur , Françoise Debart

European Journal of Organic Chemistry, 2015, 2015 (2), pp.302-308. ⟨10.1002/ejoc.201403381⟩

Article dans une revue istex hal-03554798v1
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mRNA maturation in giant viruses: variation on a theme

Stéphane Priet , Audrey Lartigue , Françoise Debart , Jean-Michel Claverie , Chantal Abergel

Nucleic Acids Research, 2015, 43, pp.3776-3788. ⟨10.1093/nar/gkv224⟩

Article dans une revue hal-01214084v1

Synthesis, binding, nuclease resistance and cellular uptake properties of 2′- O -acetalester-modified oligonucleotides containing cationic groups

Annabelle Biscans , Sonia Rouanet , Jean-Rémi Bertrand , Jean-Jacques Vasseur , Christelle Dupouy et al.

Bioorganic and Medicinal Chemistry Letters, 2015, 23 (17), pp.5360-5368. ⟨10.1016/j.bmc.2015.07.054⟩

Article dans une revue istex hal-03554637v1

Direct Synthesis of Partially Modified 2′-O-Pivaloyloxymethyl RNAs by a Base-Labile Protecting Group Strategy and their Potential for Prodrug-Based Gene-Silencing Applications.

Annabelle Biscans , Maxence Bos , Anthony R. Martin , Nicholas Ader , Georg Sczakiel et al.

ChemBioChem, 2014, 15 (18), pp.2674-2679. ⟨10.1002/cbic.201402382⟩

Article dans une revue istex hal-01101605v1
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Ecological catalysis and phytoextraction: symbiosis for future

Vincent Escande , Laetitia Garoux , Claire Grison , Yann Thillier , Francoise Debart et al.

Applied Catalysis B: Environmental, 2014, 7th International Conference on Environmental Catalysis (ICEC2012), Lyon, France, 146, pp.279-288. ⟨10.1016/j.apcatb.2013.04.011⟩

Article dans une revue hal-03177603v1
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Metallophyte wastes and polymetallic catalysis: a promising combination in green chemistry. The illustrative synthesis of 59-capped RNA3

Yann Thillier , Guillaume Losfeld , Vincent Escande , Christelle Dupouy , Jean-Jacques Vasseur et al.

RSC Advances, 2013, 3 (15), pp.5204-5212. ⟨10.1039/C3RA23115A⟩

Article dans une revue hal-03173870v1

Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.

Karine Barral , Corinne Sallamand , Christiane Petzold , Bruno Coutard , Axelle Collet et al.

Antiviral Research, 2013, 99 (3), pp.292-300. ⟨10.1016/j.antiviral.2013.06.001⟩

Article dans une revue istex hal-00874640v1

Bacillus subtilis RNA deprotection enzyme RppH recognizes guanosine in the second position of its substrates

Jérémie Piton , Valéry Larue , Yann Thillier , Audrey Dorleans , Olivier Pellegrini et al.

Proceedings of the National Academy of Sciences of the United States of America, 2013, 110 (22), pp.8858-8863. ⟨10.1073/pnas.1221510110⟩

Article dans une revue hal-00829351v1

Solid-phase synthesis of 5′-triphosphate 2′-5′-oligoadenylates analogs with 3′-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs.

Yann Thillier , Sarah K Stevens , Christabel Moy , Taylor Joshua , Jean-Jacques Vasseur et al.

Bioorganic and Medicinal Chemistry, 2013, 21 (17), pp.5461-5469. ⟨10.1016/j.bmc.2013.06.008⟩

Article dans une revue istex hal-00874543v1

The biolabile 2'-O-pivaloyloxymethyl modification in an RNA helix: an NMR solution structure

Carine Lima-Baraguey , Eveline Lescrinier , Thomas Lavergne , Francoise Debart , Piet Herdewijn et al.

Organic & Biomolecular Chemistry, 2013, 11, pp.2638-2647. ⟨10.1039/c3ob27005j⟩

Article dans une revue hal-00805121v1

FTIR and UV Spectroscopy Studies of Triplex Formation Between Pyrimidine Methoxyethylphosphoramidates α- Oligodeoxynucleotides and ds DNA Targets

Bei-Wen Sun , Frédéric Geinguenaud , Eliane Taillandier , Magali Naval , Alain Laurent et al.

Journal of Biomolecular Structure and Dynamics, 2012, 19 (6), pp.1073-1081. ⟨10.1080/07391102.2002.10506810⟩

Article dans une revue hal-04648544v1
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Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N 7)-methyl transferase

Yann Thillier , Etienne Decroly , François Morvan , Bruno Canard , Jean-Jacques Vasseur et al.

RNA, 2012, 18 (4), pp.856-868. ⟨10.1261/rna.030932.111⟩

Article dans une revue hal-00700861v1
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Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome

Barbara Selisko , Supanee Potisopon , Rym Agred , Stephane Priet , Isabelle Varlet et al.

PLoS Pathogens, 2012, 8 (9), pp.e1002912. ⟨10.1371/journal.ppat.1002912⟩

Article dans une revue hal-00733199v1

Synthesis and Preliminary Evaluation of pro-RNA 2'-O-Masked with Biolabile Pivaloyloxymethyl Groups in an RNA Interference Assay

Thomas Lavergne , Carine Baraguey , Christelle Dupouy , N. Parey , Winfried Wuensche et al.

Journal of Organic Chemistry, 2011, 76, pp.5719-5731. ⟨10.1021/jo200826h⟩

Article dans une revue hal-00616629v1

Efficient solid-phase chemical synthesis of 5'-triphosphates of DNA, RNA and their analogues.

Ivan Zlatev , Thomas Lavergne , Françoise Debart , Jean-Jacques Vasseur , Muthiah Manoharan et al.

Organic Letters, 2010, 12, pp.2190-2193. ⟨10.1021/ol1004214⟩

Article dans une revue hal-00519477v1

Chemical synthesis of RNA with base-labile 2'-O-(pivaloyloxymethyl)-protected ribonucleoside phosphoramidites.

Thomas Lavergne , Michaël Janin , Christelle Dupouy , Jean-Jacques Vasseur , Françoise Debart

Current Protocols in Nucleic Acid Chemistry, 2010, Supplement 43, pp.3.19.1-3.19.27. ⟨10.1002/0471142700.nc0319s43⟩

Article dans une revue hal-00556631v1

From anionic to cationic alpha-anomeric oligodeoxynucleotides.

François Morvan , Françoise Debart , Jean-Jacques Vasseur

Chemistry and Biodiversity, 2010, 7, pp.494-535. ⟨10.1002/cbdv.200900220⟩

Article dans une revue istex hal-00476462v1

Efficient release of base-sensitive oligonucleotides from solid supports using fluoride ions.

T. Lavergne , N. Parey , J.-J. Vasseur , F. Debart

European Journal of Organic Chemistry, 2009, pp.2190-2194. ⟨10.1002/ejoc.200801275⟩

Article dans une revue hal-00376886v1

Assessment of new 2'-O-acetalester protecting groups for regular RNA synthesis and original 2'-modified proRNA.

Anthony R. Martin , Thomas Lavergne , Jean-Jacques Vasseur , Françoise Debart

Bioorganic and Medicinal Chemistry Letters, 2009, 19, pp.4046-4049. ⟨10.1016/j.bmcl.2009.06.015⟩

Article dans une revue istex hal-00412360v1

A base labile group for 2'-OH protection of ribonucleosides : as a major challenge for RNA synthesis.

T. Lavergne , J.-R. Bertrand , J.-J. Vasseur , F. Debart

Chemistry - A European Journal, 2008, 14, pp.9135-9138. ⟨10.1002/chem.200801392⟩

Article dans une revue istex hal-00346580v1

Chemical modifications to improve the cellular uptake of oligonucleotides.

Françoise Debart , Saïd Abes , Gaelle Deglane , Hong M Moulton , Philippe Clair et al.

Current Topics in Medicinal Chemistry, 2007, 7 (7), pp.727-37. ⟨10.2174/156802607780487704⟩

Article dans une revue istex hal-00150534v1

5-propynylamino alpha-deoxyuridine promotes DNA duplex stabilization of anionic and neutral but not cationic alpha-oligonucleotides.

Gaëlle Deglane , François Morvan , Françoise Debart , Jean-Jacques Vasseur

Bioorganic and Medicinal Chemistry Letters, 2007, 17, pp.951-954. ⟨10.1016/j.bmcl.2006.11.052⟩

Article dans une revue istex hal-00137368v1

Effect of DNA modifications on DNA processing by HIV-1 integrase and inhibitor binding.

Allison A. Johnson , Jane M. Sayer , Haruhiko Yagi , Sachindra S. Patil , Françoise Debart et al.

Journal of Biological Chemistry, 2006, 281 (43), pp.32428-32438

Article dans une revue hal-00109066v1

Impact of the guanidinium group on hybridization and cellular uptake of cationic oligonucleotides.

Gaëlle Deglane , Said Abes , Thibaud Michel , Paul Prevot , Eric Vivès et al.

ChemBioChem, 2006, 7, pp.684-692

Article dans une revue hal-00022245v1

First evaluation of acyloxymethyl or acylthiomethyl groups as biolabile 2'-O-protections of RNA.

Nora Parey , Carine Baraguey , Jean-Jacques Vasseur , Françoise Debart

Organic Letters, 2006, 8, pp.3869-3872

Article dans une revue hal-00097408v1
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Highly Stable DNA Triplexes Formed with Cationic Phosphoramidate Pyrimidine α‐Oligonucleotides

Thibaut Michel , Francoise Debart , Frédéric Heitz , Jean-Jacques Vasseur

ChemBioChem, 2005, 6 (7), pp.1254-1262. ⟨10.1002/cbic.200400436⟩

Article dans une revue hal-04600743v1

Toward high yield synthesis of peptide–oligonucleotide chimera through a disulfide bridge: A simplified method for oligonucleotide activation

Frédéric Maurel , Françoise Debart , Florine Cavelier , Alain Thierry , Bernard Lebleu et al.

Bioorganic and Medicinal Chemistry Letters, 2005, 15 (22), pp.5084-5087. ⟨10.1016/j.bmcl.2005.07.086⟩

Article dans une revue istex hal-03824545v1
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Efficient guanidination of the phosphate linkage towards cationic phosphoramidate oligonucleotides

Thibaut Michel , Francoise Debart , Jean-Jacques Vasseur

Tetrahedron Letters, 2003, 44 (35), pp.6579-6582. ⟨10.1016/S0040-4039(03)01694-0⟩

Article dans une revue hal-04600871v1
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Cationic phosphoramidate -oligonucleotides efficiently target single-stranded DNA and RNA and inhibit hepatitis C virus IRES-mediated translation

Thibaut Michel , Camille Martinand-Mari , Francoise Debart , Bernard Lebleu , Ian Robbins et al.

Nucleic Acids Research, 2003, 31 (18), pp.5282 - 5290. ⟨10.1093/nar/gkg733⟩

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FTIR and UV Spectroscopy Studies of Triplex Formation Between α-Oligonucleotides with Non-Ionic Phoshoramidate Linkages and DNA Targets

Thibault Michel , Francoise Debart , Jean-Jacques Vasseur , Frédéric Geinguenaud , Eliane Taillandier

Journal of Biomolecular Structure and Dynamics, 2003, 21 (3), pp.435-445. ⟨10.1080/07391102.2003.10506938⟩

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2-Amino-α-2′-deoxyadenosine increased duplex stability of methoxyethylphosphoramidate α-Oligodeoxynucleotides with RNA target

Magali Naval , Thibaut Michel , Jean-Jacques Vasseur , Francoise Debart

Bioorganic and Medicinal Chemistry Letters, 2002, 12 (11), pp.1435-1438. ⟨10.1016/s0960-894x(02)00215-9⟩

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Use of MALDI-TOF mass spectrometry to monitor solid-phase synthesis of oligonucleotides

T Guerlavais , Albert Meyer , Francoise Debart , J-L Imbach , François Morvan et al.

Analytical and Bioanalytical Chemistry, 2002, 374 (1), pp.57-63. ⟨10.1007/s00216-002-1395-7⟩

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Synthesis, DNA binding and biological evaluation of synthetic precursors and novel analogs of netropsin

Francoise Debart , Christian Périgaud , Gilles Gosselin , Driss Mrani , Bernard Rayner et al.

Journal of Medicinal Chemistry, 2002, 32 (5), pp.1074-1083. ⟨10.1021/jm00125a024⟩

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Chiral and steric effects in the efficient binding of α α α α-anomeric deoxyoligonucleoside N-alkylphosphoramidates to ssDNA and RNA

A. Laurent , Magali Naval , Françoise Debart , J.J. Vasseur , Bernard Rayner

Nucleic Acids Research, 1999, 27 (21), pp.4151 - 4159. ⟨10.1093/nar/27.21.4151⟩

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Anomeric inversion (from β to α) in methylphosphonate oligonucleosides enhances their affinity for DNA and RNA

Françoise Debart , Albert Meyer , J.J. Vasseur , Bernard Rayner

Nucleic Acids Research, 1998, 26 (20), pp.4551 - 4556. ⟨10.1093/nar/26.20.4551⟩

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A new route to oligodeoxynucleoside phosphoramidates (PNH2)

Alain Laurent , Francoise Debart , Bernard Rayner

Tetrahedron Letters, 1997, 38 (30), pp.5285-5288. ⟨10.1016/S0040-4039(97)01153-2⟩

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Esterase-triggered fluorescence of fluorogenic oligonucleotides

Alain Laurent , Francoise Debart , Ned J. Lamb , Bernard Rayner

Bioconjugate Chemistry, 1997, 8 (6), pp.856-861. ⟨10.1021/bc970168i⟩

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Chimeric alpha‐beta oligonucleotides as antisense inhibitors of reverse transcription

Claudine Boiziau , Françoise Debart , Bernard Rayner , Jean-Louis Imbach , Jean-Jacques Toulme

FEBS Letters, 1995, 361 (1), pp.41-45. ⟨10.1016/0014-5793(95)00138-y⟩

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Optimization of hybridizing abilities and nuclease resistance in the design of chimeric α-anomeric oligodeoxynucleotides containing β-anomeric gaps

Francoise Debart , Guilhem Tosquellas , Bernard Rayner , Jean-Louis Imbach

Bioorganic and Medicinal Chemistry Letters, 1994, 4 (8), pp.1041-1046. ⟨10.1016/S0960-894X(01)80678-8⟩

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Efficient and Stereoselective Synthesis of 3′-Deoxy 3′ - C -Branched-Chain Substituted Thymidine

Yogesh Sanghvi , Ramesh Bharadwaj , Francoise Debart , Alain de Mesmaeker

Synthesis: Journal of Synthetic Organic Chemistry, 1994, 1994 (11), pp.1163-1166. ⟨10.1055/s-1994-25664⟩

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Synthesis and base-pairing properties of the nuclease-resistant α-anomeric dodecaribonucleotide α-[r(UCUUAACCCACA)]

Francoise Debart , Bernard Rayner , Genevieve Degols , Jean-Louis Imbach

Nucleic Acids Research, 1992, 20 (6), pp.1193-1200. ⟨10.1093/nar/20.6.1193⟩

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Intermolecular radical C-C bond formation: Synthesis of a novel dinucleoside linker for non-anionic antisense oligonucleosides

Francoise Debart , Jean-Jacques Vasseur , Yogesh Sanghvi , P. Dan Cook

Tetrahedron Letters, 1992, 33 (19), pp.2645-2648. ⟨10.1016/S0040-4039(00)79047-2⟩

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Synthesis and incorporation of methyleneoxy(methylimino) linked thymidine dimer into antisense oligonucleosides

Francoise Debart , Jean-Jacques Vasseur , Yogesh Sanghvi , P. Dan Cook

Bioorganic and Medicinal Chemistry Letters, 1992, 2 (12), pp.1479-1482. ⟨10.1016/S0960-894X(00)80412-6⟩

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Caractérisation de nouveaux dérivés et analogues de la nétropsine et identification de leurs intermédiaires de synthèse par spectrométrie de masse FAB

Jean‐Louis Aubagnac , Francoise Debart , Driss Mrani , Gilles Gosselin , Bernard Rayner et al.

Journal of Heterocyclic Chemistry, 1991, 28 (1), pp.145-151. ⟨10.1002/jhet.5570280126⟩

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Synthesis, DNA binding properties and biological evaluation of novel oligo-meta-benzamides related to netropsin

Francoise Debart , Gilles Gosselin , Bernard Rayner , P Le Ber , C Auclair et al.

European Journal of Medicinal Chemistry, 1991, 26 (3), pp.261-271. ⟨10.1016/0223-5234(91)90058-U⟩

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Sugar modified oligonucleotides : II. Solid phase synthesis of nuclease resistant α-anomeric uridylates as potential antisense agents

Francoise Debart , Bernard Rayner , Jeon-Louis Imbach

Tetrahedron Letters, 1990, 31 (25), pp.3537-3540. ⟨10.1016/S0040-4039(00)94436-8⟩

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Structure and Conformation of the Duplex Consensus 5′-Splice Site d [(CpApGpGpTpApApGpT) (ApCpTpTpApCpCpTpG)] Deduced from High Field 1 H-NMR of the Non-Exchangeable and Imino Protons

Francoise Debart , Bernard Rayner , Jean-Louis Imbach , Moses Lee , Ding-Kwo Chang et al.

Journal of Biomolecular Structure and Dynamics, 1987, 5 (1), pp.47-65. ⟨10.1080/07391102.1987.10506374⟩

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Structure and Conformation of the Duplex Consensus Acceptor Exon: Intron Junction d [(CpTpApCpApGpGpT) (ApCpCpTpGpTpApG)] deduced from High-Field 1 H-NMR of Non-Exchangeable and Imino Protons

Francoise Debart , Bernard Rayner , Jean-Louis Imbach , Ding-Kwo Chang , J. William Lown

Journal of Biomolecular Structure and Dynamics, 1986, 4 (3), pp.343-363. ⟨10.1080/07391102.1986.10506354⟩

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1 H and 31 P-NMR Assignments of the Non-exchangeable Protons of the Consensus Acceptor Exon: Intron Junction d(CpTpApCpApGpGpT)

J. William Lown , Ding-Kwo Chang , Francoise Debart , Bernard Rayner , Jean-Louis Imbach

Journal of Biomolecular Structure and Dynamics, 1986, 3 (6), pp.1171-1187. ⟨10.1080/07391102.1986.10508493⟩

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From Anionic to Cationic Alpha-Oligodeoxynucleosides

F. Morvan , F. Debart , J.-J. Vasseur

Martin Egli, Piet Herdewijn. Chemistry and Biology of Nucleic Acids, Verlag Helvetica Chemica Acta, Zürich, Switzerland in Wiley-VCH, Weinheim, Federal Republic Germany, pp.79-120, 2012

Chapitre d'ouvrage hal-00676559v1