Frédéric Adam

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β4GALT1-CDG uncovers a novel mechanism of Von Willebrand factor deficiency through impaired glycosylation and accelerated

Claire Auditeau , Frédéric Adam , Arnaud Bruneel , François Fenaille , Christelle Repérant et al.

Hämostaseologie, 2026, GTH Congress 2026 – 70th Annual Meeting of the Society of Thrombosis and Haemostasis Research Bonn, Germany, 17.–20.02.2026, 46 (S01), pp.S73-S74. ⟨10.1055/s-0045-1814603⟩

Article dans une revue hal-05534728v1

Total Thrombus Formation system exploration of primary haemostasis in cirrhotic patients

Johan Abdoul , Norman Luc , Bérangère Joly , Antoine Jehl , Adeline Blandinières et al.

Research and Practice in Thrombosis and Haemostasis, 2026, pp.103370. ⟨10.1016/j.rpth.2026.103370⟩

Article dans une revue hal-05487282v1
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F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets

Jean Solarz , Christelle Soukaseum , Stéphane Frémont , Sébastien Eymieux , Camilia Nabli et al.

Nature Communications, 2025, 16 (1), pp.7375. ⟨10.1038/s41467-025-62487-2⟩

Article dans une revue hal-05206235v2
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Unveiling platelet aging with progressive β-galactose exposure as a signature of platelet senescence in humans and mice

Catherine Angénieux , Thomas Nipoti , Gabriel Rojas-Jiménez , Mélanie Daniel , Frédéric Adam et al.

Haematologica, 2025, ⟨10.3324/haematol.2025.287812⟩

Article dans une revue hal-05146639v1
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Somatic RAP1B gain-of-function variant underlies isolated thrombocytopenia and immunodeficiency

Marta Benavides-Nieto , Frédéric Adam , Emmanuel Martin , Charlotte Boussard , Chantal Lagresle-Peyrou et al.

The Journal of clinical investigation, 2024, 134 (17), pp.e169994. ⟨10.1172/JCI169994.⟩

Article dans une revue hal-05389225v1
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A small-molecule hemostatic agent for the reversal of direct oral anticoagulant–induced bleeding

Maximilien Desvages , Delphine Borgel , Frédéric Adam , Ge Tu , Simon Jaouen et al.

Research and Practice in Thrombosis and Haemostasis, 2024, 8 (4), pp.102426. ⟨10.1016/j.rpth.2024.102426⟩

Article dans une revue hal-04927372v1
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Fitusiran reduces bleeding in factor X–deficient mice

Sebastien Verhenne , Geneviève Mccluskey , Hortense Maynadié , Frédéric Adam , Caterina Casari et al.

Blood, 2024, 144 (2), pp.227-236. ⟨10.1182/blood.2023023404⟩

Article dans une revue hal-04654300v1
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MAGT1 deficiency in XMEN disease is associated with severe platelet dysfunction and impaired platelet glycoprotein N-glycosylation

Alexandre Kauskot , Coralie Mallebranche , Arnaud Bruneel , François Fenaille , Jean Solarz et al.

Journal of Thrombosis and Haemostasis, 2023, ⟨10.1016/j.jtha.2023.05.007⟩

Article dans une revue hal-04106364v1
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ADP receptor P2Y12 is the capstone of the cross-talk between Ca 2+ mobilization pathways dependent on ATPases SERCA3 and SERCA2b in platelet

Miao Feng , Béatrice Hechler , Frédéric Adam , Christian Gachet , Anita Eckly et al.

Research and Practice in Thrombosis and Haemostasis, In press

Article dans une revue (data paper) hal-03930689v1
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DOCK11 deficiency in patients with X-linked actinopathy and autoimmunity

Charlotte Boussard , Laure Delage , Tania Gajardo , Alexandre Kauskot , Maxime Batignes et al.

Blood, 2023

Article dans une revue hal-04246983v1
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Efficacy of platelet-inspired hemostatic nanoparticles on bleeding in Von Willebrand disease murine models

Stéphanie Roullet , Norman Luc , Julie Rayes , Jean Solarz , Dante Disharoon et al.

Blood, 2023, 141 (23), pp.2891-2900. ⟨10.1182/blood.2022018956⟩

Article dans une revue inserm-04066466v1
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DOCK11 deficiency in patients with X-linked actinopathy and autoimmunity

Charlotte Boussard , Laure Delage , Tania Gajardo , Alexandre Kauskot , Maxime Batignes et al. Article dans une revue hal-04455529v1
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Long-term safety and efficacy of lentiviral hematopoietic stem/progenitor cell gene therapy for Wiskott–Aldrich syndrome

A. Magnani , M. Semeraro , F. Adam , C. Booth , Loïc Dupré et al.

Nature Medicine, 2022, 28 (1), pp.71-80. ⟨10.1038/s41591-021-01641-x⟩

Article dans une revue hal-03776861v1
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New insights into regulation of αIIbβ3 integrin signaling by filamin A

Lamia Lamrani , Frédéric Adam , Christelle Soukaseum , Cécile Denis , Hana Raslova et al.

Research and Practice in Thrombosis and Haemostasis, 2022, 6 (2), pp.e12672. ⟨10.1002/rth2.12672⟩

Article dans une revue hal-04471560v1

Antithrombotic potential of a single‐domain antibody enhancing the activated protein C‐cofactor activity of protein S

Josepha Sedzro , Frédéric Adam , Claire Auditeau , Elsa Bianchini , Allan de Carvalho et al.

Journal of Thrombosis and Haemostasis, 2022, 20 (7), pp.1653-1664. ⟨10.1111/jth.15736⟩

Article dans une revue inserm-04455219v1

A gain‐of‐function filamin A mutation in mouse platelets induces thrombus instability

Frédéric Adam , Alexandre Kauskot , Lamia Lamrani , Jean Solarz , Christelle Soukaseum et al.

Journal of Thrombosis and Haemostasis, 2022, 20 (11), pp.2666-2678. ⟨10.1111/jth.15864⟩

Article dans une revue hal-03896872v1
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Author Correction: Long-term safety and efficacy of lentiviral hematopoietic stem/progenitor cell gene therapy for Wiskott–Aldrich syndrome

A. Magnani , M. Semeraro , F. Adam , C. Booth , L. Dupré et al.

Nature Medicine, 2022, 28 (10), pp.2217-2217. ⟨10.1038/s41591-022-01985-y⟩

Article dans une revue hal-03990393v1

Long-Term Follow-up Study after Lentiviral Hematopoietic Stem/Progenitor Cell Gene Therapy for Wiskott - Aldrich Syndrome

Alessandra Magnani , Michaela Semeraro , Frédéric Adam , Claire Booth , Loic Dupre et al.

Blood, 2021, 138 (Supplement 1), pp.2934-2934. ⟨10.1182/blood-2021-147697⟩

Article dans une revue hal-04018920v1
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Anti-inflammatory Activity of the Protein Z-Dependent Protease Inhibitor

Mahita Razanakolona , Frédéric Adam , Elsa Bianchini , François Saller , Allan De Carvalho et al.

TH Open : Companion Journal To Thrombosis and Haemostasis, 2021, 5 (2), pp.220-229. ⟨10.1055/s-0041-1730037⟩

Article dans une revue hal-04003175v1
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NAADP/SERCA3-dependent Ca2+ stores pathway specifically controls early autocrine ADP secretion potentiating platelet activation.

Miao Feng , Ziane Elaïb , Delphine Borgel , Cécile Denis , Frédéric Adam et al.

Circulation Research, 2020, 127 (7), pp.e166-e183. ⟨10.1161/CIRCRESAHA.119.316090⟩

Article dans une revue inserm-02948394v1
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Relevance of platelet desialylation and thrombocytopenia in type 2B von Willebrand disease: preclinical and clinical evidence

Annabelle Dupont , Christelle Soukaseum , Mathilde Cheptou , Frédéric Adam , Thomas Nipoti et al.

Haematologica, 2019, HITH, pp.haematol.2018.206250. ⟨10.3324/haematol.2018.206250⟩

Article dans une revue hal-02347340v1

Kinesin-1 Is a New Actor Involved in Platelet Secretion and Thrombus Stability

Frédéric Adam , Alexandre Kauskot , Mathieu Kurowska , Nicolas Goudin , Isabelle Munoz et al.

Arteriosclerosis, Thrombosis, and Vascular Biology, 2018, 38 (5), pp.1037-1051. ⟨10.1161/ATVBAHA.117.310373⟩

Article dans une revue inserm-02440288v1

A mutation of the human EPHB2 gene leads to a major platelet functional defect

Eliane Berrou , Christelle Soukaseum , Rémi Favier , Frédéric Adam , Ziane Elaib et al.

Blood, 2018, 132 (19), pp.2067-2077. ⟨10.1182/blood-2018-04-845644⟩

Article dans une revue hal-04449239v1
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TUBB1 mutations cause thyroid dysgenesis associated with abnormal platelet physiology

Athanasia Stoupa , Frédéric Adam , Dulanjalee Kariyawasam , Catherine Strassel , Sanjay Gawade et al.

EMBO Molecular Medicine, 2018, ⟨10.15252/emmm.201809569⟩

Article dans une revue hal-02375086v1
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A mutation in the gene coding for the sialic acid transporter SLC35A1 is required for platelet life span but not proplatelet formation

Alexandre Kauskot , Tiffany Pascreau , Frédéric Adam , Arnaud Bruneel , Christelle Reperant et al.

Haematologica, 2018, 103 (12), pp.e613-e617. ⟨10.3324/haematol.2018.198028⟩

Article dans une revue hal-04455614v1

Gain-of-Function Mutation in Filamin A Potentiates Platelet Integrin αβ Activation

Eliane Berrou , Frédéric Adam , Marilyne Lebret , Virginie Planche , Patricia Fergelot et al.

Arteriosclerosis, Thrombosis, and Vascular Biology, 2017, 37 (6), pp.1087-1097. ⟨10.1161/ATVBAHA.117.309337⟩

Article dans une revue hal-02083035v1

A Novel Single-Domain Antibody Against von Willebrand Factor A1 Domain Resolves Leukocyte Recruitment and Vascular Leakage During Inflammation—Brief Report

Gabriel Ayme , Frédéric Adam , Paulette Legendre , Amine Bazaa , Valérie Proulle et al.

Arteriosclerosis, Thrombosis, and Vascular Biology, 2017, 37 (9), pp.1736-1740. ⟨10.1161/ATVBAHA.117.309319⟩

Article dans une revue pasteur-03209478v1
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Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity

Marion Pepin , Soraya Mezouar , Julie Pegon , Vincent Muczynski , Frédéric Adam et al.

Scientific Reports, 2016, 6 (1), pp.37953. ⟨10.1038/srep37953⟩

Article dans une revue hal-01455400v1

LIM kinase/cofilin dysregulation promotes macrothrombocytopenia in severe von Willebrand disease-type 2B

Alexandre Kauskot , Sonia Poirault-Chassac , Frédéric Adam , Vincent Muczynski , Gabriel Ayme et al.

JCI Insight, 2016, 1 (16), pp.e88643. ⟨10.1172/jci.insight.88643⟩

Article dans une revue hal-03209475v1

Platelet JNK1 is involved in secretion and thrombus formation

Frédéric Adam , Alexandre Kauskot , Paquita Nurden , Eric Sulpice , Marc Hoylaerts et al.

Blood, 2010, 115 (20), pp.4083-4092. ⟨10.1182/blood-2009-07-233932⟩

Article dans une revue hal-04723472v1
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A novel β1-tubulin mutation associated with secretion-dependent platelet hyperactivity and prothrombotic risk via GPVI and CLEC-2 engagement

Toscane Viellard , Jean Solarz , Christelle Repérant , Christelle Soukaseum , Johannes A Eble et al.

7th EUPLAN International Conference, Sep 2025, Wuerzburg, Germany

Communication dans un congrès inserm-05293799v1

vWF/GPIb mechano-dependent interactions require F-actin disassembly by the oxidoreductase MICAL1

Jean Solarz , Christelle Soukaseum , Christelle Reperant , Stéphane Frémont , Thibaud Séfiane et al.

GTH, 2025, 69th Annual Meeting of the Society of Thrombosis and Haemostasis Research – Advances Research Technology Education, Feb 2025, Lausanne ( CH), Switzerland. pp.S97, ⟨10.1055/s-0044-1801697⟩

Communication dans un congrès hal-05077230v1

Une nouvelle mutation de la tubuline β1 associée à un profil prothrombotique dépendant de l’axe GPVI et de la sécrétion

Toscane Viellard , Christelle Repérant , Jean Solarz , Jean-Claude Bordet , Cécile Denis et al.

Congrès de la Société Française d'Hématologie, Apr 2025, Paris, France

Communication dans un congrès hal-05151565v1

F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIBa interaction in platelets

Jean Solarz , Christelle Soukaseum , Stéphane Frémont , Sébastien Eymieux , Camilia Nabli et al.

Société Française de Thrombose et d'hémostase, Oct 2025, Lyon, France

Communication dans un congrès hal-05305768v1

Modulation mécanosensible des interactions vWF/GPIb par le désassemblage du cytosquelette d'actine induit par MICAL1

Jean Solarz , Christelle Soukaseum , Stéphane Frémont , Christelle Repérant , Sébastien Eymieux et al.

Société Française d'hématologie, Apr 2025, Paris, France

Communication dans un congrès hal-05151554v1

Mise en évidence dans un modèle murin d’un risque prothrombotique associé à une mutation de la tubuline β1

Toscane Viellard , Christelle Repérant , Jean Solarz , Jean-Claude Bordet , Cécile Denis et al.

Congrès Français d'Hémostase, Société Française de Thrombose et d'Hémostase, Sep 2024, Lille, France

Communication dans un congrès hal-04701038v1

Mise en évidence dans un modèle murin d’un risque prothrombotique associé à une mutation de la tubuline β1

Toscane Viellard , Christelle Repérant , Jean Solarz , Jean-Claude Bordet , Cécile Denis et al.

Congrès Français d'Hémostase (CFH) 2024, Sep 2024, Lille, France

Communication dans un congrès hal-05151543v1

Une nouvelle mutation de la tubuline β1 associée à un profil prothrombotique dépendant de l’axe GPVI et de la sécrétion

Toscane Viellard , Christelle Repérant , Jean Solarz , Jean-Claude Bordet , Cécile Denis et al.

Club Français des Plaquettes et des Mégacaryocytes (CFPM), Oct 2024, Saint Etienne, France

Communication dans un congrès hal-05151561v1

MICAL1, un nouvel acteur moléculaire impliqué dans la stabilisation du thrombus

Jean Solarz , Christelle Soukaseum , Cécile Denis , Frédéric Adam , Alexandre Kauskot

Congrès Société Française d’Hématologie 2023, Mar 2023, Paris, France

Communication dans un congrès hal-04455383v1

MICAL1, un nouvel acteur des forces contractiles dans le thrombus

Jean Solarz , Christelle Soukaseum , Frédéric Adam , Cécile Denis , Alexandre Kauskot

Club Français de Plaquettes et des Mégacaryocytes, May 2022, Bordeaux, France

Communication dans un congrès hal-04455372v1

Effects of platelet-inspired haemostatic nanoparticles on bleeding in von Willebrand disease murine models

Stéphanie Roullet , Norman Luc , Julie Rayes , Frédéric Adam , Andrew J Dito et al.

ISTH 2022 Congress, International Society of Thrombosis and Hemostasis, 2022, Londres, United Kingdom

Communication dans un congrès hal-04455066v1

THE EXPANDING PHENOTYPE OF MKL1 DEFICIENCY: FROM INFECTIOUS SUSCEPTIBILITY TO IMMUNE DYSREGULATION

Marta Benavides-Nieto , Alexandre Kauskot , Frédéric Adam , Antoine de Giacomoni , Alice Corsia et al.

20th Biennial Meeting of the European Society for Immunodeficiencies (ESID), Oct 2022, Gothenburg, Sweden

Communication dans un congrès hal-04455616v1

Impaired lymphocyte trafficking and platelet activation in a patient with de novo mutation in RAP1B

Marta Benavides-Nieto , Frédéric Adam , Emmanuel Martin , Chantal Lagresle-Peyrou , Guillaume Morelle et al.

20th Biennial Meeting of the European Society for Immunodeficiencies (ESID); Gothenburg, Sweden, Oct 2022, Gothenburg, Sweden

Communication dans un congrès hal-04455647v1

Antithrombotic Potential of a Single-domain Antibody Enhancing the Anticoagulant Activity of Protein S

Josepha Sedzro , Frédéric Adam , Allan De Carvalho , Elsa P Bianchini , Ivan Peyron et al.

Hybrid Congress of the International Society on Thrombosis and Haemostasis, International Society on Thrombosis and Haemostasis, Jul 2021, Philadelphia (Pennsylvania), United States. pp.Abstract OC 60.2

Communication dans un congrès hal-04501112v1

Long-Term Follow-Up Study after Lentiviral Hematopoietic Stem/Progenitor Cell Gene Therapy for Wiskott-Aldrich Syndrome

Alessandra Magnani , Frédéric Adam , Michaela Semeraro , Loïc Dupré , Aurélie Gabrion et al.

ASGCT 23rd Annual Meeting, May 2020, Boston (MA), United States. pp.Abstract 111

Communication dans un congrès hal-04455733v1

Caractérisation d’une nanobody qui potentialize l’activité cofacteur de la protéine C active de la protéine S

Sedzro Jc , Francois Saller , Frédéric Adam , De Carvalho , Sophie Gandrille et al.

40ème congrès de la Société Française d’Hématologie, Société Française d’Hématologie, Sep 2020, Paris, France. pp.Page 39, Abstract 04-01

Communication dans un congrès hal-04501074v1

La diminution de l’activité des pompes à calcium SERCA3 permet la réduction de la réponse inflammatoire.

Kathia Beddek , Frédéric Adam , Francois Saller , Delphine Borgel , Regis Bobe

40eme congres de la SFH 2020, Sep 2020, Paris, France

Communication dans un congrès hal-04455333v1

Maladie de Willebrande type 2B et thrombopénies : Impact de la désialylation des plaquettes.

Annabelle Dupont , Christelle Soukaseum , Frédéric Adam , Paulette Legendre , Valérie Proulle et al.

38th Congress of the Société Française d’Hématologie, Société Française d’Hématologie, Mar 2018, Paris, France. pp.Page 143, Abstract 12-88

Communication dans un congrès hal-04457466v1
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A novel β1-tubulin mutation associated with a secretion-dependent platelet hyperactivity and prothrombotic risk

Toscane Viellard , Jean Solarz , Christelle Repérant , Christelle Soukaseum , Cécile Denis et al.

ECTH 2025 Prague, Oct 2025, Prague (CZ), Czech Republic

Poster de conférence hal-05351155v1

Contrôle mécanosensible de la dynamique de l’actine dans la fonctionnalité de la GPIbα par MICAL1

Jean Solarz , Christelle Soukaseum , Christelle Repérant , Cécile Denis , Dominique Baruch et al.

Congrès Français d'Hémostase, Sep 2024, Lille, France

Poster de conférence hal-04701025v1

MICAL1 links actin dynamics to shear-dependent adhesive and thrombotic function of platelets

Jean Solarz , Christelle Soukaseum , Christelle Repérant , Cécile Denis , Frédéric Adam et al.

Congrès Français d’Hémostase, May 2023, Saint-Malo, France

Poster de conférence hal-04455404v1

Le récepteur PAR4 initie la voie SERCA3/NAADP qui potentialise l'activation des plaquettes en réponse à la thrombine.

Miao Feng , Frédéric Adam , Alexandre Kauskot , Cécile Denis , Marijke Bryckaert et al.

Congrès Francais d'Hémostase, May 2023, Saint malo, France

Poster de conférence hal-04455436v1

MICAL1, a new molecular actor involved in thrombus growth and stability

Jean Solarz , Christelle Soukaseum , Christelle Repérant , Stéphane Frémont , Cécile Denis et al.

Gordon Research Conference, Cell Biology of Megakaryocytes and Platelets, Mar 2023, Lucca (Barga), Italy

Poster de conférence hal-05151535v1

MAGT1 DEFICIENCY CAUSES A PROMINENT PLATELETS DYSFUNCTION THROUGH IMPAIRMENT OF MEMBRANE GLYCOPROTEINS N-GLYCOSYLATION

Alexandre Kauskot , Coralie Mallebranche , Jean Solarz , Miao Feng , Toscane Viellard et al.

20th Biennial Meeting of the European Society for Immunodeficiencies (ESID), Oct 2022, Gothenburg, Sweden. Abstract 801

Poster de conférence hal-04455514v1

Ca2+ release from Sarco/Endoplamic Reticulum Ca2+-ATPase 3 (SERCA3) controlled stores is involved in endothelial permeability and inflammatory response.

Kathia Beddek , Frédéric Adam , Francois Saller , Delphine Borgel , Regis Bobe

ISTH 2020, Jul 2020, Virtual conference, France

Poster de conférence hal-04455301v1

NAADP/SERCA3-dependent Ca2+ stores pathway specifically controls early autocrine ADP secretion potentiating platelet activation.

Miao Feng , Ziane Elaib , Delphine Borgel , Cécile V. Denis , Frédéric Adam et al.

ISTH 2020, Jul 2020, Virtual congress, France

Poster de conférence hal-04455286v1

PLATELET SIALYLATION AS A NEW BIOMARKER OF IMMATURE PLATELETS

Thomas Nipoti , Valerie Proulle , Frédéric Adam , Alexandre Kauskot

ECTH 2019, Oct 2019, Glasgow (Ecosse), United Kingdom

Poster de conférence hal-04454905v1

Relevance of platelet desialylation and thrombocytopenia in type 2B von Willebrand disease

Annabelle Dupont , Christelle Soukaseum , Mathilde Cheptou , Frédéric Adam , Thomas Nipoti et al.

GRC, Cell biology of megakaryocytes and platelets, 2019, Mar 2019, Galveston - Texas, United States

Poster de conférence hal-04455289v1

Modulation of the platelet count by Romiplostim and inhibitors of LIM kinase in genetically-engineered von Willebrand disease type 2B mice: in vivo evaluation of haemostatic efficiency.

Mathilde Cheptou , Frédéric Adam , Olivier Christophe , Peter Lenting , Cécile Denis et al.

ECTH, 2018, Oct 2018, Marseille, France

Poster de conférence hal-04455308v1

Specific mobilization of SERCA3-dependent Ca2+ stores by NAADP regulates platelet activity through ADP secretion.

Ziane Elaib , Miao Feng , Frédéric Adam , Marijke Bryckaert , Jean‐philippe Rosa et al.

15th International Meeting of the European Calcium Society, Sep 2018, Hambourg (Germany), Germany

Poster de conférence hal-04455185v1