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Frédéric Becq

Professeur de Physiologie, Université de Poitiers
126
Documents

Domaines de recherche

Sciences du Vivant [q-bio]

Publications

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Effect of hypoxia on Cystic Fibrosis Transmembrane conductance Regulator channel corrected by Elexacaftor/Tezacaftor/Ivacaftor

Clarisse Vandebrouck , K. Pascarel , Jenny Colas , Thomas Carrez , Christine Barrault
Medical Research Archives, 2024, 12 (2), ⟨10.18103/mra.v12i2.4909⟩
Article dans une revue hal-04496971v1

The impact of hypoxia on the ion channels in cystic fibrosis bronchial epithelial cells

K. Pascarel , J. Colas , S. Mirval , F. Becq , C. Vandebrouck
Revue des Maladies Respiratoires, 2023, 40 (3), pp.230-233. ⟨10.1016/j.rmr.2023.01.014⟩
Article dans une revue hal-04040380v1

The rescue of F508del-CFTR by elexacaftor/tezacaftor/ivacaftor (Trikafta) in human airway epithelial cells is underestimated due to the presence of ivacaftor

Frédéric Becq , Sandra Mirval , Thomas Carrez , Manuella Lévêque , Arnaud Billet
European Respiratory Journal, 2022, 59 (2), pp.2100671. ⟨10.1183/13993003.00671-2021⟩
Article dans une revue hal-04541610v1

The rescue of F508del-CFTR by elexacaftor/tezacaftor/ivacaftor (Trikafta) in human airway epithelial cells is underestimated due to the presence of ivacaftor

Frédéric Becq , Sandra Mirval , Thomas Carrez , Manuella Lévêque , Arnaud Billet
European Respiratory Journal, 2022, 59 (2), pp.2100671. ⟨10.1183/13993003.00671-2021⟩
Article dans une revue hal-03679018v1
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The multi-faceted nature of 15 CFTR exonic variations: Impact on their functional classification and perspectives for therapy

Anne Bergougnoux , A. Billet , C. Ka , M. Heller , F. Degrugillier
Journal of Cystic Fibrosis, 2022, ⟨10.1016/j.jcf.2022.12.003⟩
Article dans une revue hal-03913493v1

Involvement of CFTR in the pathogenesis of pulmonary arterial hypertension

Hélène Le Ribeuz , Lucie To , Maria-Rosa Ghigna , Clémence Martin , Chandran Nagaraj
European Respiratory Journal, 2021, 58 (5), pp.2000653. ⟨10.1183/13993003.00653-2020⟩
Article dans une revue hal-04541903v1
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CFTR et mucoviscidose, une histoire cinquantenaire

Frédéric Becq
Médecine/Sciences, 2021, 37 (6-7), pp.654-659. ⟨10.1051/medsci/2021089⟩
Article dans une revue hal-03273144v1
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Myelinosome organelles in the retina of r6/1 huntington disease (Hd) mice: ubiquitous distribution and possible role in disease spreading

M.G. Yefimova , E. Béré , A. Cantereau-Becq , Annie-Claire Meunier-Balandre , B. Merceron
International Journal of Molecular Sciences, 2021, 22 (23), pp.12771. ⟨10.3390/ijms222312771⟩
Article dans une revue hal-03468899v2
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Involvement of CFTR in the pathogenesis of pulmonary arterial hypertension

Hélène Le Ribeuz , Lucie To , Maria-Rosa Ghigna , Clémence Martin , Chandran Nagaraj
European Respiratory Journal, 2021, 58 (5), pp.2000653. ⟨10.1183/13993003.00653-2020)⟩
Article dans une revue hal-03499886v1

Phospholipase C controls chloride-dependent short-circuit current in human bronchial epithelial cells

Chloé Grebert , Frédéric Becq , Clarisse Vandebrouck
American Journal of Physiology - Lung Cellular and Molecular Physiology, 2021, 320 (2), pp.L205-L219. ⟨10.1152/ajplung.00437.2019⟩
Article dans une revue hal-04040390v1

Phospholipase C controls chloride-dependent short-circuit current in human bronchial epithelial cells

Chloé Grebert , Frédéric Becq , Clarisse Vandebrouck
American Journal of Physiology - Lung Cellular and Molecular Physiology, 2021, 320 (2), pp.L205-L219. ⟨10.1152/ajplung.00437.2019⟩
Article dans une revue hal-04541620v1
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Quantitative phase imaging to study transmembrane water fluxes regulated by CFTR and AQP3 in living human airway epithelial CFBE cells and CHO cells

Jodie Llinares , Anne Cantereau , Lionel Froux , Frédéric Becq
PLoS ONE, 2020, 15 (5), pp.e0233439. ⟨10.1371/journal.pone.0233439⟩
Article dans une revue hal-03113355v1

Quantitative phase imaging to study transmembrane water fluxes regulated by CFTR and AQP3 in living human airway epithelial CFBE cells and CHO cells

Jodie Llinares , Anne Cantereau , Lionel Froux , Frédéric Becq
PLoS ONE, 2020, 15 (5), pp.e0233439. ⟨10.1371/journal.pone.0233439⟩
Article dans une revue hal-04541616v1
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Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity

Lionel Froux , Ahmad Elbahnsi , Benjamin Boucherle , Arnaud Billet , Nesrine Baatallah
European Journal of Medicinal Chemistry, 2020, 190, pp.112116. ⟨10.1016/j.ejmech.2020.112116⟩
Article dans une revue hal-02924784v1

Functional and Pharmacological Characterization of the Rare CFTR Mutation W361R

Arnaud Billet , Ahmad Elbahnsi , Mathilde Jollivet-Souchet , Brice Hoffmann , Jean-Paul Mornon
Frontiers in Pharmacology, 2020, 11, ⟨10.3389/fphar.2020.00295⟩
Article dans une revue hal-04541908v1
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Functional and Pharmacological Characterization of the Rare CFTR Mutation W361R

Arnaud Billet , Ahmad Elbahnsi , Mathilde Jollivet-Souchet , Brice Hoffmann , Jean-Paul Mornon
Frontiers in Pharmacology, 2020, 11, ⟨10.3389/fphar.2020.00295⟩
Article dans une revue hal-02557014v1

Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility

M. Yefimova , N. Bourmeyster , F. Becq , A. Burel , M.-T. Lavault
Morphologie, 2019, 103 (341), pp.4-10. ⟨10.1016/j.morpho.2018.11.001⟩
Article dans une revue hal-04541914v1

Transalpinecine and Analogues: First Total Synthesis, Stereochemical Revision and Biological Evaluation

Cécile Baudoin-Dehoux , Tessa Castellan , Morgane Enel , Christiane André-Barrès , Sandra Mirval
European Journal of Organic Chemistry, 2019, 19, pp.1830-1834. ⟨10.1002/ejoc.201900071⟩
Article dans une revue hal-02330547v1

Focus on TRP channels in cystic fibrosis

Chloé Grebert , Frederic Becq , Clarisse Vandebrouck
Cell Calcium, 2019, 81, pp.29-37. ⟨10.1016/j.ceca.2019.05.007⟩
Article dans une revue hal-04541910v1
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Short-term consequences of F508del-CFTR thermal instability on CFTR-dependent transepithelial currents in human airway epithelial cells

Lionel Froux , Christelle Coraux , Edouard Sage , Frédéric Becq
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-50066-7⟩
Article dans une revue hal-02448604v1
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Focus on TRP channels in cystic fibrosis

Chloé Grebert , Frederic Becq , Clarisse Vandebrouck
Cell Calcium, 2019, 81, pp.29 - 37. ⟨10.1016/j.ceca.2019.05.007⟩
Article dans une revue hal-03484344v1

Short-term consequences of F508del-CFTR thermal instability on CFTR-dependent transepithelial currents in human airway epithelial cells

Lionel Froux , Christelle Coraux , Edouard Sage , Frédéric Becq
Scientific Reports, 2019, 9 (1), pp.13729. ⟨10.1038/s41598-019-50066-7⟩
Article dans une revue hal-04541618v1

Modulating the cystic fibrosis transmembrane regulator and the development of new precision drugs

Lionel Froux , Arnaud Billet , Frédéric Becq
Expert Review of Precision Medicine and Drug Development, 2018, 3 (6), pp.357-370. ⟨10.1080/23808993.2018.1547109⟩
Article dans une revue hal-03192898v1

Modulation of cellular membrane properties as a potential therapeutic strategy to counter lipointoxication in obstructive pulmonary diseases

Linette Kadri , Romain Ferru-Clément , Amélie Bacle , Laurie-Anne Payet , Anne Cantereau
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2018, 1864 (9), pp.3069-3084. ⟨10.1016/j.bbadis.2018.06.021⟩
Article dans une revue hal-04541917v1

Modulation of cellular membrane properties as a potential therapeutic strategy to counter lipointoxication in obstructive pulmonary diseases

Linette Kadri , Romain Ferru-Clement , Amélie Bacle , Laurie-Anne Payet , Anne Cantereau
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2018, 1864, pp.3069 - 3084. ⟨10.1016/j.bbadis.2018.06.021⟩
Article dans une revue hal-03119809v1

Calumenin contributes to ER-Ca(2+) homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention.

Réginald Philippe , Fabrice Antigny , Paul Buscaglia , Caroline Norez , Florentin Huguet
Cell Calcium, 2017, 62, pp.47-59. ⟨10.1016/j.ceca.2017.01.011⟩
Article dans une revue hal-01528587v1

In cellulo analyses of the p.Val322Ala mutation on the CFTR protein conformation and activity

Raëd Farhat , Ayman El-Seedy , Ariestya Indah Permata Sari , Caroline Norez , Marie-Claude Pasquet
Comptes Rendus Biologies, 2017, 340 (8), pp.367 - 371. ⟨10.1016/j.crvi.2017.06.001⟩
Article dans une revue hal-01708268v1

Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function

Arnaud Billet , Lionel Froux , John Hanrahan , Frederic Becq
Frontiers in Pharmacology, 2017, 8, ⟨10.3389/fphar.2017.00195⟩
Article dans une revue hal-04541920v1
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Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function

Arnaud Billet , Lionel Froux , John Hanrahan , Frederic Becq
Frontiers in Pharmacology, 2017, 8, pp.195. ⟨10.3389/fphar.2017.00195⟩
Article dans une revue hal-03191777v1

Calumenin contributes to ER-Ca2+ homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention

Réginald Philippe , Fabrice Antigny , Paul Buscaglia , Caroline Norez , Florentin Huguet
Cell Calcium, 2017, 62, pp.47-59. ⟨10.1016/j.ceca.2017.01.011⟩
Article dans une revue hal-04541923v1

Heterozygous mutation of CFTR gene leads to activation of autophagy in Sertoli cells

C. Ravel , Nicolas Bourmeyster , F. Becq , A. Burel , M. T. Lavault
Human Reproduction, 2017, 32 (suppl_1), pp.i159-i159. ⟨10.1093/humrep/32.Supplement_1.1⟩
Article dans une revue hal-01688588v1

In cellulo analyses of the p.Val322Ala mutation on the CFTR protein conformation and activity

Raëd Farhat , Ayman El-Seedy , Ariestya Indah Permata Sari , Caroline Norez , Marie-Claude Pasquet
Comptes Rendus. Biologies, 2017, 340 (8), pp.367-371. ⟨10.1016/j.crvi.2017.06.001⟩
Article dans une revue hal-04541918v1

Myelinosomes act as natural secretory organelles in Sertoli cells to prevent accumulation of aggregate-prone mutant Huntingtin and CFTR

Marina G. Yefimova , Emile Béré , Anne Cantereau-Becq , Thomas Harnois , Annie-Claire Meunier
Human Molecular Genetics, 2016, 25 (19), pp.4170-4185. ⟨10.1093/hmg/ddw251⟩
Article dans une revue hal-03686913v1
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Pushing the limits of catalytic C–H amination in polyoxygenated cyclobutanes

Pierre-Antoine Nocquet , Raphael Hensienne , Joanna Wencel-Delord , Eugénie Laigre , Khadidja Sidelarbi
Organic & Biomolecular Chemistry, 2016, 14 (9), pp.2780-2796. ⟨10.1039/C5OB02602D⟩
Article dans une revue hal-02410808v1

Targeting surface voids to counter membrane disorders in lipointoxication-related diseases

Romain Ferru-Clément , Miroslava Spanova , Shalinee Dhayal , Noel Morgan , Reynald Hélye
Journal of Cell Science, 2016, ⟨10.1242/jcs.183590⟩
Article dans une revue hal-04541929v1
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Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

Laurent Meijer , Deborah Nelson , Vladimir Riazanski , Aida Gabdoulkhakova , Geneviève Héry-Arnaud
Journal of Innate Immunity, 2016, 8 (4), pp.330-349. ⟨10.1159/000444256⟩
Article dans une revue hal-02042979v1

Myelinosomes act as natural secretory organelles in Sertoli cells to prevent accumulation of aggregate-prone mutant Huntingtin and CFTR

Marina Yefimova , Emile Béré , Anne Cantereau-Becq , Thomas Harnois , Annie-Claire Meunier
Human Molecular Genetics, 2016, 25 (19), pp.4170-4185. ⟨10.1093/hmg/ddw251⟩
Article dans une revue hal-04541928v1

Targeting surface voids to counter membrane disorders in lipointoxication-related diseases.

Romain Ferru-Clément , Miroslava Spanova , Shalinee Dhayal , Noel G Morgan , Reynald Hélye
Journal of Cell Science, 2016, 129 (12), pp.2368-81. ⟨10.1242/jcs.183590⟩
Article dans une revue hal-01337179v1
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The Pig: A Relevant Model for Evaluating the Neutrophil Serine Protease Activities during Acute Pseudomonas aeruginosa Lung Infection.

Claire Chevaleyre , Mickaël Riou , Deborah Brea , Clarisse Vandebrouck , Céline Barc
PLoS ONE, 2016, 11 (12), pp.e0168577. ⟨10.1371/journal.pone.0168577⟩
Article dans une revue hal-01437131v1

Predicting CFTR activity with front-runner cystic fibrosis drugs.

Frédéric Becq
EBioMedicine, 2015, pp.100-1. ⟨10.1016/j.ebiom.2015.01.013⟩
Article dans une revue hal-01177773v1

SERCA and PMCA pumps contribute to the deregulation of Ca2+ homeostasis in human CF epithelial cells

Réginald Philippe , Fabrice Antigny , Paul Buscaglia , Caroline Norez , Frédéric Becq
Biochimica et Biophysica Acta - Molecular Cell Research, 2015, 1853 (5), pp.892-903. ⟨10.1016/j.bbamcr.2015.01.010⟩
Article dans une revue hal-04541942v1

Vasorelaxation induced by dodoneine is mediated by calcium channels blockade and carbonic anhydrase inhibition on vascular smooth muscle cells

Grégoire Carre , Maurice Ouedraogo , Christophe Magaud , Hélène Carreyre , Frédéric Becq
Journal of Ethnopharmacology, 2015, 169, pp.8-17. ⟨10.1016/j.jep.2015.03.037⟩
Article dans une revue hal-04541937v1

Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors

V. Cendret , T. Legigan , A. Mingot , S. Thibaudeau , I. Adachi
Organic & Biomolecular Chemistry, 2015, 13 (43), pp.10734-10744. ⟨10.1039/c5ob01526j⟩
Article dans une revue hal-04541931v1

A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in human epithelial cells

Johanna Bertrand , Luc Dannhoffer , Fabrice Antigny , Laura Vachel , Christophe Jayle
European Journal of Pharmacology, 2015, 765, pp.337-345. ⟨10.1016/j.ejphar.2015.08.005⟩
Article dans une revue hal-04541933v1

Involvement of the Cdc42 Pathway in CFTR Post-Translational Turnover and in Its Plasma Membrane Stability in Airway Epithelial Cells

Romain Ferru-Clément , Fleur Fresquet , Caroline Norez , Thierry Métayé , Frédéric Becq
PLoS ONE, 2015, 10 (3), pp.e0118943. ⟨10.1371/journal.pone.0118943⟩
Article dans une revue hal-04541940v1

Function, pharmacological correction and maturation of new Indian CFTR gene mutations

Himanshu Sharma , Mathilde Jollivet Souchet , Isabelle Callebaut , Rajendra Prasad , Frédéric Becq
Journal of Cystic Fibrosis, 2015, 14 (1), pp.34-41. ⟨10.1016/j.jcf.2014.06.008⟩
Article dans une revue hal-01099879v1

A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in human epithelial cells

Johanna Bertrand , Luc Dannhoffer , Fabrice Antigny , Laura Vachel , Christophe Jayle
European Journal of Pharmacology, 2015, 765, pp.337-345. ⟨10.1016/j.ejphar.2015.08.005⟩
Article dans une revue hal-04040417v1
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Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.

V. Cendret , T. Legigan , A. Martin-Mingot , S. Thibaudeau , I. Adachi
Organic & Biomolecular Chemistry, 2015, 13 (43), pp.10734-10744. ⟨10.1039/c5ob01526j⟩
Article dans une revue hal-01500682v1

SERCA and PMCA pumps contribute to the deregulation of Ca(2+) homeostasis in human CF epithelial cells.

Réginald Philippe , Fabrice Antigny , Paul Buscaglia , Caroline Norez , Frédéric Becq
Biochimica et Biophysica Acta - Molecular Cell Research, 2015, 1853 (5), pp.892-903. ⟨10.1016/j.bbamcr.2015.01.010⟩
Article dans une revue hal-01134260v1

The low PLC-δ1 expression in cystic fibrosis bronchial epithelial cells induces upregulation of TRPV6 channel activity

Laura Vachel , Caroline Norez , Christophe Jayle , Frédéric Becq , Clarisse Vandebrouck
Cell Calcium, 2015, 57 (1), pp.38-48. ⟨10.1016/j.ceca.2014.11.005⟩
Article dans une revue hal-04541945v1

The hypotensive agent dodoneine inhibits L-type Ca2+ current with negative inotropic effect on rat heart.

Grégoire Carré , Hélène Carreyre , Maurice Ouedraogo , Frédéric Becq , Patrick Bois
European Journal of Pharmacology, 2014, 728, pp.119-27. ⟨10.1016/j.ejphar.2014.01.059⟩
Article dans une revue hal-00990335v1
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Improvement of chloride transport defect by gonadotropin-releasing hormone (GnRH) in cystic fibrosis epithelial cells.

Nathalie Benz , Sophie Le Hir , Caroline Norez , Mathieu Kerbiriou , Marie-Laure Calvez
PLoS ONE, 2014, 9 (2), pp.e88964. ⟨10.1371/journal.pone.0088964⟩
Article dans une revue hal-00990343v1

The human CFTR protein expressed in CHO cells activates aquaporin-3 in a cAMP-dependent pathway: study by digital holographic microscopy.

Pascal Jourdain , Frédéric Becq , Sylvain Lengacher , Clément Boinot , Pierre J Magistretti
Journal of Cell Science, 2014, 127 (Pt 3), pp.546-56. ⟨10.1242/jcs.133629⟩
Article dans une revue hal-00990312v1

ANO1 contributes to angiotensin-II-activated Ca2+-dependent Cl- current in human atrial fibroblasts.

Antoun El Chemaly , Caroline Norez , Christophe Magaud , Jocelyn Bescond , Aurelien Chatelier
Journal of Molecular and Cellular Cardiology, 2014, 68, pp.12-9. ⟨10.1016/j.yjmcc.2013.12.027⟩
Article dans une revue hal-00990329v1

Cystic fibrosis bronchial epithelial cells are lipointoxicated by membrane palmitate accumulation.

Laurie-Anne Payet , Linette Kadri , Sébastien Giraud , Caroline Norez , Jean Marc Berjeaud
PLoS ONE, 2014, 9 (2), pp.e89044. ⟨10.1371/journal.pone.0089044⟩
Article dans une revue hal-00990346v1

Bronchorelaxation of the human bronchi by CFTR activators

Caroline Norez , Christophe Jayle , Frédéric Becq , Clarisse Vandebrouck
Pulmonary Pharmacology and Therapeutics, 2014, 27 (1), pp.38-43. ⟨10.1016/j.pupt.2013.06.008⟩
Article dans une revue hal-04040435v1

The low PLC-δ1 expression in cystic fibrosis bronchial epithelial cells induces upregulation of TRPV6 channel activity.

Laura Vachel , Caroline Norez , Christophe Jayle , Frédéric Becq , Clarisse Vandebrouck
Cell Calcium, 2014, 57 (1), pp.38-48. ⟨10.1016/j.ceca.2014.11.005⟩
Article dans une revue hal-01134274v1

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors

J. Désiré , M. Mondon , N. Fontelle , S. Nakagawa , Y. Hirokami
Organic & Biomolecular Chemistry, 2014, 12 (44), pp.8977-8996. ⟨10.1039/c4ob00325j⟩
Article dans une revue hal-01311606v1

Strategies to circumvent the CFTR defect in cystic fibrosis.

Frédéric Becq , Marc Chanson
Front Pharmacol, 2013, 4, pp.108. ⟨10.3389/fphar.2013.00108⟩
Article dans une revue hal-00990355v1

Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia.

Thassadite Dirami , Baptiste Rode , Mathilde Jollivet , Nathalie da Silva , Denise Escalier
American Journal of Human Genetics, 2013, 92 (5), pp.760-6. ⟨10.1016/j.ajhg.2013.03.016⟩
Article dans une revue hal-00990664v1

Rescue of functional CFTR channels in cystic fibrosis: a dramatic multivalent effect using iminosugar cluster-based correctors.

Philippe Compain , Camille Decroocq , Antoine Joosten , Julien de Sousa , David Rodríguez-Lucena
ChemBioChem, 2013, 14 (15), pp.2050-8. ⟨10.1002/cbic.201300312⟩
Article dans une revue hal-00990168v1
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Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain

Norbert Odolczyk , Janine Fritsch , Caroline Norez , Nathalie Servel , Melanie Faria da Cunha
EMBO Molecular Medicine, 2013, 5 (10), pp.1484 - 1501. ⟨10.1002/emmm.201302699⟩
Article dans une revue hal-00990522v1

Saturated fatty acids alter the late secretory pathway by modulating membrane properties.

Laurie-Anne Payet , Ludovic Pineau , Ellen C R Snyder , Jenny Colas , Ahmed Moussa
Traffic, 2013, 14 (12), pp.1228-41. ⟨10.1111/tra.12117⟩
Article dans une revue hal-00990166v1

Effect of VX-770 (ivacaftor) and OAG on Ca2+ influx and CFTR activity in G551D and F508del-CFTR expressing cells.

Laura Vachel , Caroline Norez , Frédéric Becq , Clarisse Vandebrouck
Journal of Cystic Fibrosis, 2013, 12 (6), pp.584-91. ⟨10.1016/j.jcf.2013.05.008⟩
Article dans une revue hal-00990531v1

CFTR: Effect of ICL2 and ICL4 amino acids in close spatial proximity on the current properties of the channel

Arnaud Billet , Jean-Paul Mornon , Mathilde Jollivet , Pierre Lehn , Isabelle Callebaut
Journal of Cystic Fibrosis, 2013, 12, pp.737-745. ⟨10.1016/j.jcf.2013.02.002⟩
Article dans une revue hal-00907930v1

C-branched iminosugars: α-glucosidase inhibition by enantiomers of isoDMDP, isoDGDP, and isoDAB-L-isoDMDP compared to miglitol and miglustat.

Sarah F Jenkinson , Daniel Best , a Waldo Saville , James Mui , R Fernando Martínez
Journal of Organic Chemistry, 2013, 78 (15), pp.7380-97. ⟨10.1021/jo4005487⟩
Article dans une revue hal-00990546v1

CFTR mutation combinations producing frequent complex alleles with different clinical and functional outcomes

Ayman El-Seedy , Emmanuelle Girodon , Caroline Norez , Julie Pajaud , Marie-Claude Pasquet
Human Mutation, 2012, 33 (11), pp.1557-1565. ⟨10.1002/humu.22129⟩
Article dans une revue hal-02446189v1
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Deficit of osteoprotegerin release by osteoblasts from a patient with cystic fibrosis.

Annelise Gimenez-Maitre , Carole Le Henaff , Caroline Norez , Christine Guillaume , Bruno Ravoninjatovo
European Respiratory Journal, 2012, 39 (3), pp.780-1. ⟨10.1183/09031936.00104111⟩
Article dans une revue inserm-00602058v1

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain.

Nicolas Ardes-Guisot , Dominic S Alonzi , Gabriele Reinkensmeier , Terry D Butters , Caroline Norez
Organic & Biomolecular Chemistry, 2011, 9 (15), pp.5373-5388. ⟨10.1039/c1ob05119a⟩
Article dans une revue hal-00608881v1
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Stimulation of wild-type, F508del- and G551D-CFTR chloride channels by non-toxic modified pyrrolo[2,3-b]pyrazine derivatives

Luc Dannhoffer , Arnaud Billet , Mathilde Jollivet-Souchet , Patricia Melin-Heschel , Christelle Faveau
Frontiers in Pharmacology, 2011, 2, ⟨10.3389/fphar.2011.00048⟩
Article dans une revue hal-03192023v1

4-C-Me-DAB and 4-C-Me-LAB - enantiomeric alkyl-branched pyrrolidine iminosugars - are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group.

Filipa P da Cruz , Scott Newberry , Sarah F Jenkinson , Mark R Wormald , Terry D Butters
Tetrahedron Letters, 2011, 52 (2), pp.219-223. ⟨10.1016/j.tetlet.2010.10.173⟩
Article dans une revue hal-00580432v1

Transient receptor potential canonical channel 6 links Ca2+ mishandling to cystic fibrosis transmembrane conductance regulator channel dysfunction in cystic fibrosis.

Fabrice Antigny , Caroline Norez , Luc Dannhoffer , Johanna Bertrand , Dorothée Raveau
American Journal of Respiratory Cell and Molecular Biology, 2011, 44 (1), pp.83-90. ⟨10.1165/rcmb.2009-0347OC⟩
Article dans une revue hal-00559252v1

An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors.

Brice-Loïc Renard , Benjamin Boucherle , Bruno Maurin , Marie-Carmen Molina , Caroline Norez
European Journal of Medicinal Chemistry, 2011, 46 (5), pp.1935-41. ⟨10.1016/j.ejmech.2011.02.037⟩
Article dans une revue hal-00582439v1

Transient Receptor Potential Canonical Channel 6 Links Ca 2+ Mishandling to Cystic Fibrosis Transmembrane Conductance Regulator Channel Dysfunction in Cystic Fibrosis

Fabrice Antigny , Caroline Norez , Luc Dannhoffer , Johanna Bertrand , Dorothée Raveau
American Journal of Respiratory Cell and Molecular Biology, 2011, 44 (1), pp.83-90. ⟨10.1165/rcmb.2009-0347oc⟩
Article dans une revue hal-04040448v1

CFTR and Ca2+ Signaling in Cystic Fibrosis.

Fabrice Antigny , Caroline Norez , Frédéric Becq , Clarisse Vandebrouck
Front Pharmacol, 2011, 2, pp.67. ⟨10.3389/fphar.2011.00067⟩
Article dans une revue hal-00664651v1

From the vasodilator and hypotensive effects of an extract fraction from Agelanthus dodoneifolius (DC) Danser (Loranthaceae) to the active compound dodoneine

Maurice Ouedraogo , M. Ruiz , E. Vardelle , Hélène Carreyre , Jean-Marie Coustard
Journal of Ethnopharmacology, 2011, 133 (2), pp.345-352. ⟨10.1016/j.jep.2010.10.002⟩
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Cystic fibrosis transmembrane conductance regulator modulators for personalized drug treatment of cystic fibrosis: progress to date.

Frédéric Becq
Drugs, 2010, 70 (3), pp.241-59. ⟨10.2165/11316160-000000000-00000⟩
Article dans une revue hal-00582426v1

C terminus of nucleotide binding domain 1 contains critical features for cystic fibrosis transmembrane conductance regulator trafficking and activation.

Arnaud Billet , Patricia Melin , Mathilde Jollivet , Jean-Paul Mornon , Isabelle Callebaut
Journal of Biological Chemistry, 2010, 285 (29), pp.22132-40. ⟨10.1074/jbc.M110.120683⟩
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Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia.

Ophélia Granio , Katherine J D Ashbourne Excoffon , Petra Henning , Patricia Melin , Caroline Norez
Human Gene Therapy, 2010, 21 (3), pp.251-69. ⟨10.1089/hum.2009.056⟩
Article dans une revue hal-00580553v1

Understanding nucleotide binding and CFTR ion channel gating: how many cycles?

Frédéric Becq , Arnaud Billet
Expert Review of Respiratory Medicine, 2010, 4 (4), pp.451-4. ⟨10.1586/ers.10.47⟩
Article dans une revue hal-00561612v1

Identification of a novel water-soluble activator of wild-type and F508del CFTR: GPact-11a.

J. Bertrand , B. Boucherle , A. Billet , P. Melin-Heschel , L. Dannhoffer
European Respiratory Journal, 2010, 36 (2), pp.311-22. ⟨10.1183/09031936.00122509⟩
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Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugars

Daniel Best , Sarah F Jenkinson , Waldo A. Saville , Dominic S Alonzi , Mark R Wormald
Tetrahedron Letters, 2010, 51 (32), pp.4170-4174. ⟨10.1016/j.tetlet.2010.05.131⟩
Article dans une revue hal-00580537v1

CFTR channels and adenosine triphosphate release: the impossible rendez-vous revisited in skeletal muscle.

Frédéric Becq
The Journal of Physiology, 2010, 588 (Pt 23), pp.4605-6. ⟨10.1113/jphysiol.2010.200113⟩
Article dans une revue hal-00582430v1

SiRNA calnexin promotes endogenous F508del-CFTR trafficking

D. Raveau , A. Cantereau , F. Becq , C. Norez
Journal of Cystic Fibrosis, 2009, 8, pp.S19. ⟨10.1016/S1569-1993(09)60078-3⟩
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A cystic fibrosis respiratory epithelial cell chronically treated by miglustat acquires a non-cystic fibrosis-like phenotype.

Caroline Norez , Fabrice Antigny , Sabrina Noel , Clarisse Vandebrouck , Frédéric Becq
American Journal of Respiratory Cell and Molecular Biology, 2009, 41 (2), pp.217-225. ⟨10.1165/rcmb.2008-0285OC⟩
Article dans une revue hal-00444213v1

Dysfunction of mitochondria Ca2+ uptake in cystic fibrosis airway epithelial cells

Fabrice Antigny , Nathalie Girardin , Dorothée Raveau , Maud Frieden , Frédéric Becq
Mitochondrion, 2009, 9 (4), pp.232-241. ⟨10.1016/j.mito.2009.02.003⟩
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Rescue of functional F508del cystic fibrosis transmembrane conductance regulator by vasoactive intestinal peptide in the human nasal epithelial cell line JME/CF15.

Sara Rafferty , Nicole Alcolado , Caroline Norez , Frederic Chappe , Siegried Pelzer
Journal of Pharmacology and Experimental Therapeutics, 2009, 331 (1), pp.2-13
Article dans une revue hal-00444202v1

Stimulation of salivary secretion in vivo by CFTR potentiators in Cftr+/+ and Cftr−/− mice

Sabrina Noël , Pierre-Olivier Strale , Luc Dannhoffer , Martina Wilke , Hugo Dejonge
Journal of Cystic Fibrosis, 2008, 7 (2), pp.128-133. ⟨10.1016/j.jcf.2007.06.005⟩
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Proteasome-Dependent Pharmacological Rescue of Cystic Fibrosis Transmembrane Conductance Regulator Revealed by Mutation of Glycine 622

Caroline Norez , Frédéric Bilan , Alain Kitzis , Yvette Mettey , Frédéric Becq
Journal of Pharmacology and Experimental Therapeutics, 2008, 25 (1), pp.89-99. ⟨10.1124/jpet.107.134502⟩
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Guanabenz, an α2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells

Caroline Norez , Clarisse Vandebrouck , Fabrice Antigny , Luc Dannhoffer , Marc Blondel
European Journal of Pharmacology, 2008, 592 (1-3), pp.33-40. ⟨10.1016/j.ejphar.2008.06.103⟩
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Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells.

Frédéric Bilan , Magali Nacfer , Fleur Fresquet , Caroline Norez , Patricia Melin
Experimental Cell Research, 2008, 314 (11-12), pp.2199-2211. ⟨10.1016/j.yexcr.2008.04.012⟩
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Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells.

Sabrina Noël , Martina Wilke , Alice G. M. Bot , Hugo R. de Jonge , Frédéric Becq
Journal of Pharmacology and Experimental Therapeutics, 2008, 325 (1), pp.1016-1023. ⟨10.1124/jpet.107.135582⟩
Article dans une revue hal-00402085v1

9-Phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels

Teddy Grand , Marie Demion , Caroline Norez , Yvette Mettey , Pierre Launay
British Journal of Pharmacology, 2008, 153 (8), pp.1697-1705. ⟨10.1038/bjp.2008.38⟩
Article dans une revue hal-00393981v1
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Abnormal spatial diffusion of Ca2+ in F508del-CFTR airway epithelial cells

Fabrice Antigny , Caroline Norez , Anne Cantereau , Frédéric Becq , Clarisse Vandebrouck
Respiratory Research, 2008, 9 (1), pp.70. ⟨10.1186/1465-9921-9-70⟩
Article dans une revue hal-03119859v1

Anti-inflammatory effect of miglustat in bronchial epithelial cells

Maria Cristina Decheccchi , Elena Nicolis , Caroline Norez , Valentino Bezzerri , Monica Borgatti
Journal of Cystic Fibrosis, 2008, 7 (6), pp.555-565. ⟨10.1016/j.jcf.2008.06.002⟩
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NHE-RF1 protein rescues DeltaF508-CFTR function

Florian Bossard , Amal Robay , Gilles Toumaniantz , Shehrazade Dahimene , Frédéric Becq
American Journal of Physiology - Lung Cellular and Molecular Physiology, 2007, 292 (5), pp.1085-1094. ⟨10.1152/ajplung.00445.2005⟩
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Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries.

Robert Renaud , Jean Pierre Savineau , Caroline Norez , Frederic Becq , Christelle Guibert
European Respiratory Journal, 2007, ⟨10.1183/09031936.00060007⟩
Article dans une revue hal-02439706v1

Structure Elucidation of a Dihydropyranone from Tapinanthus dodoneifolius

Maurice Ouedraogo , Hélène Carreyre , Clarisse Vandebrouck , Jocelyn Bescond , Guy Raymond
Journal of Natural Products, 2007, 70 (12), pp.2006-2009
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Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR

Fabrice Antigny , Caroline Norez , Frédéric Becq , Clarisse Vandebrouck
Cell Calcium, 2007, 43 (2), pp.175-183. ⟨10.1016/j.ceca.2007.05.002⟩
Article dans une revue hal-00389764v1

CFTR inhibition by glibenclamide requires a positive charge in cytoplasmic loop three

Patricia Melin , Eric Hosy , Michel Vivaudou , Frédéric Becq
Biochimica et Biophysica Acta:Biomembranes, 2007, 1768 (10), pp.2438-2446. ⟨10.1016/j.bbamem.2007.05.013⟩
Article dans une revue hal-00397837v1

MPB-07 Reduces the Inflammatory Response to Pseudomonas aeruginosa in CF Bronchial Cells

Maria Cristina Dechecchi , Elena Nicolis , Valentino Bezzerri , Antonio Vella , Marco Colombatti
American Journal of Respiratory Cell and Molecular Biology, 2007, 36 (5), pp.615-624. ⟨10.1165/rcmb.2006-0200OC⟩
Article dans une revue hal-00401637v1

Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high affinity inhibitors of CFTR chloride channels.

C. Routaboul , C. Norez , P. Melin , M.-C. Molina , B. Boucherle
J. Pharmacol. Exp. Ther., 2007, pp.1023-1035
Article dans une revue hal-00383202v1

Cellular Localization and Activity of Ad-Delivered GFP-CFTR in Airway Epithelial and Tracheal Cells

Ophélia Granio , Caroline Norez , Katherine J.D. Ashbourne Excoffon , Philip H. Karp , Monika Lusky
American Journal of Respiratory Cell and Molecular Biology, 2007, 37, pp.631-639. ⟨10.1165/rcmb.2007-0026TE⟩
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Structure Elucidation of a Dihydropyranone from Tapinanthus dodoneifolius

Maurice Ouedraogo , Hélène Carreyre , Clarisse Vandebrouck , Jocelyn Bescond , Guy Raymond
Journal of Natural Products, 2007, 70 (12), pp.2006-2009. ⟨10.1021/np070355x⟩
Article dans une revue hal-04040468v1

Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel

Céline Auzanneau , Caroline Norez , Fabrice Antigny , Vincent Thoreau , Chantal Jougla
Biochemical Pharmacology, 2007, 75 (2), pp.476-483. ⟨10.1016/j.bcp.2007.09.004⟩
Article dans une revue hal-00389815v1
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Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation.

Clarisse Vandebrouck , Patricia Melin , Caroline Norez , Renaud Robert , Christelle Guibert
Respiratory Research, 2006, 7 (1), pp.113. ⟨10.1186/1465-9921-7-113⟩
Article dans une revue inserm-00097884v1
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Pharmacological profile of inhibition of the chloride channels activated by extracellular acid in cultured rat Sertoli cells

Céline Auzanneau , Caroline Norez , Sabrina Noël , Chantal Jougla , Frédéric Becq
Reproduction Nutrition Development, 2006, 46 (3), pp.241-255. ⟨10.1051/rnd:2006013⟩
Article dans une revue hal-00900616v1

Pharmacological profile of inhibition of the chloride channels activated by extracellular acid in cultured rat Sertoli cells

Céline Auzanneau , Caroline Norez , Sabrina Noël , Chantal Jougla , Frédéric Becq
Reproduction Nutrition Development, 2006, 46, pp.241-255
Article dans une revue hal-00077689v1

The Glycine Residues G551 and G1349 within the ATP-Binding Cassette Signature Motifs Play Critical Roles in the Activation and Inhibition of Cystic Fibrosis Transmembrane Conductance Regulator Channels by Phloxine B

Patricia Melin , Caroline Norez , Isabelle Callebaut , Frédéric Becq
Journal of Membrane Biology, 2006, 208, pp.203-212. ⟨10.1007/s00232-005-7001-0⟩
Article dans une revue hal-00113816v1

Pharmacological profile of inhibition of the chloride channels activated by extracellular acid in cultured rat Sertoli cells

Céline Auzanneau , Caroline Norez , Sabrina Noël , Chantal Jougla , Frédéric Becq
Reproduction Nutrition Development, 2006, 46 (3), pp.241-255. ⟨10.1051/rnd:2006013⟩
Article dans une revue hal-04040482v1

Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells

C. Norez , F. Antigny , F. Becq , C. Vandebrouck
Traffic, 2006, 7, pp.562-573. ⟨10.1111/j.1600-0854.2006.00409.x⟩
Article dans une revue hal-00078138v1

General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels.

B. Marcet , F. Becq , C. Norez , P. Delmas , Bernard Verrier
British Journal of Pharmacology, 2004, 919, pp.919
Article dans une revue hal-00143529v1
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Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity

Frédéric Bilan , Vincent Thoreau , Magali Nacfer , Renaud Derand , Caroline Norez
Journal of Cell Science, 2004, 117 (10), pp.1923 - 1935. ⟨10.1242/jcs.01070⟩
Article dans une revue hal-03119932v1

Synthesis, SAR, Crystal Structure, and Biological Evaluation of Benzoquinoliziniums as Activators of Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Channels

Cécile Marivingt-Mounir , Caroline Norez , Renaud Dérand , Laurence Bulteau-Pignoux , Dung Nguyen-Huy
Journal of Medicinal Chemistry, 2004, 47 (4), pp.962-972. ⟨10.1021/jm0308848⟩
Article dans une revue hal-03610137v1
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Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Channel by β-Adrenergic Agonists and Vasoactive Intestinal Peptide in Rat Smooth Muscle Cells and Its Role in Vasorelaxation

Renaud Robert , Vincent Thoreau , Caroline Norez , Anne Cantereau , Alain Kitzis
Journal of Biological Chemistry, 2004, 279 (20), pp.21160-21168. ⟨10.1074/jbc.M312199200⟩
Article dans une revue hal-03120019v1

Acute effects of adenosine triphosphates, cyclic 3 ',5 '-adenosine monophosphates, and follicle-stimulating hormone on cytosolic calcium level in cultured immature rat Sertoli cells

Nathalie Lalevee , C. Rogier , F. Becq , M. Joffre
Biology of Reproduction, 1999, 61 (2), pp.343-352. ⟨10.1095/biolreprod61.2.343⟩
Article dans une revue hal-01619070v1

Cystic fibrosis transmembrane conductance regulator (CFTR) confers glibenclamide sensivity to outwardly rectifying chloride channel (ORCC) in Hi-5 insect cells

Marie-Pierre Julien , B. Verrier , M. Cerutti , V. Chappe , M. Gola
Journal of Membrane Biology, 1999, 168 (3), pp.229-239. ⟨10.1007/s002329900512⟩
Article dans une revue hal-02698653v1

Développement d'un modèle d'infection respiratoire aiguë à Pseudomonas aeruginosa chez le porc

Mickaël Riou , Claire C. Chevaleyre , Deborah Brea , Celine Barc , Clarisse Vandebrouck
34. Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse (RICAI), Nov 2014, Paris, France
Communication dans un congrès hal-02799765v1

Toute une histoire...

Nadine Pellen , Frédéric Becq
2012, http://www.mucoviscidose-cftr.com/2012/05/28/toute-une-histoire
Article de blog scientifique hal-02165663v1