Frédéric Becq

Professeur de Physiologie, Université de Poitiers
115
Documents

Domaines de recherche

Sciences du Vivant [q-bio]

Publications

Publications

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Effect of hypoxia on Cystic Fibrosis Transmembrane conductance Regulator channel corrected by Elexacaftor/Tezacaftor/Ivacaftor

Khilian Pascarel , Jenny Colas , Thomas Carrez , Christine Barrault , Sandra Mirval et al.
Medical Research Archives, 2024, 12 (2), ⟨10.18103/mra.v12i2.4909⟩
Article dans une revue hal-04496971 v1
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The F508del-CFTR trafficking correctors elexacaftor and tezacaftor are CFTR-independent Ca2+-mobilizing agonists normalizing abnormal Ca2+ levels in human airway epithelial cells

Manuella Lévêque , Sandra Mirval , Christine Barrault , Isabelle Fixe , Christelle Coraux et al.
Respiratory Research, 2024, 25 (1), pp.436. ⟨10.1186/s12931-024-03059-8⟩
Article dans une revue hal-04852924 v1

Impact of hypoxia in Cystic Fibrosis bronchial epithelial cells: Focus on CFTR and TRPA1 channels

Khilian Pascarel , Jenny Colas , Thomas Carrez , Sandra Mirval , Christine Barrault et al.
Revue des Maladies Respiratoires, 2024, 41 (3), pp.226. ⟨10.1016/j.rmr.2024.01.089⟩
Article dans une revue hal-04822274 v1
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The impact of hypoxia on the ion channels in cystic fibrosis bronchial epithelial cells

K. Pascarel , J. Colas , S. Mirval , F. Becq , C. Vandebrouck
Revue des Maladies Respiratoires, 2023, 40 (3), pp.230-233. ⟨10.1016/j.rmr.2023.01.014⟩
Article dans une revue hal-04040380 v1
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The multi-faceted nature of 15 CFTR exonic variations: Impact on their functional classification and perspectives for therapy

Anne Bergougnoux , A. Billet , C. Ka , M. Heller , F. Degrugillier et al.
Journal of Cystic Fibrosis, 2022, ⟨10.1016/j.jcf.2022.12.003⟩
Article dans une revue hal-03913493 v1
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The rescue of F508del-CFTR by elexacaftor/tezacaftor/ivacaftor (Trikafta) in human airway epithelial cells is underestimated due to the presence of ivacaftor

Frédéric Becq , Sandra Mirval , Thomas Carrez , Manuella Lévêque , Arnaud Billet et al.
European Respiratory Journal, 2022, 59 (2), pp.2100671. ⟨10.1183/13993003.00671-2021⟩
Article dans une revue hal-04352015 v1

Phospholipase C controls chloride-dependent short-circuit current in human bronchial epithelial cells

Chloé Grebert , Frédéric Becq , Clarisse Vandebrouck
American Journal of Physiology - Lung Cellular and Molecular Physiology, 2021, 320 (2), pp.L205-L219. ⟨10.1152/ajplung.00437.2019⟩
Article dans une revue hal-04040390 v1
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Involvement of CFTR in the pathogenesis of pulmonary arterial hypertension

Hélène Le Ribeuz , Lucie To , Maria-Rosa Ghigna , Clémence Martin , Chandran Nagaraj et al.
European Respiratory Journal, 2021, 58 (5), pp.2000653. ⟨10.1183/13993003.00653-2020⟩
Article dans une revue hal-03499886 v1
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CFTR et mucoviscidose, une histoire cinquantenaire

Frédéric Becq
Médecine/Sciences, 2021, 37 (6-7), pp.654-659. ⟨10.1051/medsci/2021089⟩
Article dans une revue hal-03273144 v1
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Myelinosome organelles in the retina of r6/1 huntington disease (Hd) mice: ubiquitous distribution and possible role in disease spreading

Marina Yefimova , Emile Béré , Anne Cantereau , Annie-Claire Balandre , Bruno Merceron et al.
International Journal of Molecular Sciences, 2021, 22 (23), pp.12771. ⟨10.3390/ijms222312771⟩
Article dans une revue hal-03468899 v2
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Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity

Lionel Froux , Ahmad Elbahnsi , Benjamin Boucherle , Arnaud Billet , Nesrine Baatallah et al.
European Journal of Medicinal Chemistry, 2020, 190, pp.112116. ⟨10.1016/j.ejmech.2020.112116⟩
Article dans une revue hal-02924784 v1
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Quantitative phase imaging to study transmembrane water fluxes regulated by CFTR and AQP3 in living human airway epithelial CFBE cells and CHO cells

Jodie Llinares , Anne Cantereau , Lionel Froux , Frédéric Becq
PLoS ONE, 2020, 15 (5), pp.e0233439. ⟨10.1371/journal.pone.0233439⟩
Article dans une revue hal-03113355 v1
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Functional and Pharmacological Characterization of the Rare CFTR Mutation W361R

Arnaud Billet , Ahmad Elbahnsi , Mathilde Jollivet-Souchet , Brice Hoffmann , Jean-Paul Mornon et al.
Frontiers in Pharmacology, 2020, 11, ⟨10.3389/fphar.2020.00295⟩
Article dans une revue hal-02557014 v1
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Focus on TRP channels in cystic fibrosis

Chloé Grebert , Frederic Becq , Clarisse Vandebrouck
Cell Calcium, 2019, 81, pp.29 - 37. ⟨10.1016/j.ceca.2019.05.007⟩
Article dans une revue hal-03484344 v1
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Short-term consequences of F508del-CFTR thermal instability on CFTR-dependent transepithelial currents in human airway epithelial cells

Lionel Froux , Christelle Coraux , Edouard Sage , Frédéric Becq
Scientific Reports, 2019, 9 (1), pp.13729. ⟨10.1038/s41598-019-50066-7⟩
Article dans une revue hal-04541618 v1
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Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility

M Yefimova , Nicolas Bourmeyster , F Becq , A Burel , M-T Lavault et al.
Morphologie, 2019, 103 (341), pp.4-10. ⟨10.1016/j.morpho.2018.11.001⟩
Article dans une revue hal-01976465 v1

Transalpinecine and Analogues: First Total Synthesis, Stereochemical Revision and Biological Evaluation

Cécile Baudoin-Dehoux , Tessa Castellan , Morgane Enel , Christiane André-Barrès , Sandra Mirval et al.
European Journal of Organic Chemistry, 2019, 19, pp.1830-1834. ⟨10.1002/ejoc.201900071⟩
Article dans une revue hal-02330547 v1

Modulation of cellular membrane properties as a potential therapeutic strategy to counter lipointoxication in obstructive pulmonary diseases

Linette Kadri , Romain Ferru-Clément , Amélie Bacle , Laurie-Anne Payet , Anne Cantereau et al.
Biochimica et Biophysica Acta - Molecular Basis of Disease, 2018, 1864 (9), pp.3069-3084. ⟨10.1016/j.bbadis.2018.06.021⟩
Article dans une revue hal-04541917 v1

Modulating the cystic fibrosis transmembrane regulator and the development of new precision drugs

Lionel Froux , Arnaud Billet , Frédéric Becq
Expert Review of Precision Medicine and Drug Development, 2018, 3 (6), pp.357-370. ⟨10.1080/23808993.2018.1547109⟩
Article dans une revue hal-03192898 v1
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In cellulo analyses of the p.Val322Ala mutation on the CFTR protein conformation and activity

Raëd Farhat , Ayman El-Seedy , Ariestya Indah Permata Sari , Caroline Norez , Marie-Claude Pasquet et al.
Comptes Rendus. Biologies, 2017, 340 (8), pp.367-371. ⟨10.1016/j.crvi.2017.06.001⟩
Article dans une revue hal-04541918 v1

Heterozygous mutation of CFTR gene leads to activation of autophagy in Sertoli cells

C. Ravel , Nicolas Bourmeyster , F. Becq , A. Burel , M. T. Lavault et al.
Human Reproduction, 2017, 32 (suppl_1), pp.i159-i159. ⟨10.1093/humrep/32.Supplement_1.1⟩
Article dans une revue hal-01688588 v1

Calumenin contributes to ER-Ca2+ homeostasis in bronchial epithelial cells expressing WT and F508del mutated CFTR and to F508del-CFTR retention

Réginald Philippe , Fabrice Antigny , Paul Buscaglia , Caroline Norez , Florentin Huguet et al.
Cell Calcium, 2017, 62, pp.47-59. ⟨10.1016/j.ceca.2017.01.011⟩
Article dans une revue hal-04541923 v1
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Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function

Arnaud Billet , Lionel Froux , John Hanrahan , Frederic Becq
Frontiers in Pharmacology, 2017, 8, pp.195. ⟨10.3389/fphar.2017.00195⟩
Article dans une revue hal-03191777 v1
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The Pig: A Relevant Model for Evaluating the Neutrophil Serine Protease Activities during Acute Pseudomonas aeruginosa Lung Infection.

Claire Chevaleyre , Mickaël Riou , Deborah Brea , Clarisse Vandebrouck , Céline Barc et al.
PLoS ONE, 2016, 11 (12), pp.e0168577. ⟨10.1371/journal.pone.0168577⟩
Article dans une revue hal-01437131 v1

Targeting surface voids to counter membrane disorders in lipointoxication-related diseases.

Romain Ferru-Clément , Miroslava Spanova , Shalinee Dhayal , Noel G Morgan , Reynald Hélye et al.
Journal of Cell Science, 2016, 129 (12), pp.2368-81. ⟨10.1242/jcs.183590⟩
Article dans une revue hal-01337179 v1
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Pushing the limits of catalytic C–H amination in polyoxygenated cyclobutanes

Pierre-Antoine Nocquet , Raphael Hensienne , Joanna Wencel-Delord , Eugénie Laigre , Khadidja Sidelarbi et al.
Organic & Biomolecular Chemistry, 2016, 14 (9), pp.2780-2796. ⟨10.1039/C5OB02602D⟩
Article dans une revue hal-02410808 v1

Myelinosomes act as natural secretory organelles in Sertoli cells to prevent accumulation of aggregate-prone mutant Huntingtin and CFTR

Marina G. Yefimova , Emile Béré , Anne Cantereau-Becq , Thomas Harnois , Annie-Claire Meunier et al.
Human Molecular Genetics, 2016, 25 (19), pp.4170-4185. ⟨10.1093/hmg/ddw251⟩
Article dans une revue hal-03686913 v1

Myelinosomes act as natural secretory organelles in Sertoli cells to prevent accumulation of aggregate-prone mutant Huntingtin and CFTR

Marina Yefimova , Emile Béré , Anne Cantereau-Becq , Thomas Harnois , Annie-Claire Meunier et al.
Human Molecular Genetics, 2016, 25 (19), pp.4170-4185. ⟨10.1093/hmg/ddw251⟩
Article dans une revue hal-04541928 v1
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Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

Laurent Meijer , Deborah Nelson , Vladimir Riazanski , Aida Gabdoulkhakova , Geneviève Héry-Arnaud et al.
Journal of Innate Immunity, 2016, 8 (4), pp.330-349. ⟨10.1159/000444256⟩
Article dans une revue hal-02042979 v1

The low PLC-δ1 expression in cystic fibrosis bronchial epithelial cells induces upregulation of TRPV6 channel activity

Laura Vachel , Caroline Norez , Christophe Jayle , Frédéric Becq , Clarisse Vandebrouck
Cell Calcium, 2015, 57 (1), pp.38-48. ⟨10.1016/j.ceca.2014.11.005⟩
Article dans une revue hal-04541945 v1
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Predicting CFTR activity with front-runner cystic fibrosis drugs

Frédéric Becq
EBioMedicine, 2015, 2 (2), pp.100-101. ⟨10.1016/j.ebiom.2015.01.013⟩
Article dans une revue hal-01177773 v1
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Synthetic deoxynojirimycin derivatives bearing a thiolated, fluorinated or unsaturated N-alkyl chain: identification of potent α-glucosidase and trehalase inhibitors as well as F508del-CFTR correctors.

V. Cendret , T. Legigan , A. Martin-Mingot , S. Thibaudeau , I. Adachi et al.
Organic & Biomolecular Chemistry, 2015, 13 (43), pp.10734-10744. ⟨10.1039/c5ob01526j⟩
Article dans une revue hal-01500682 v1

SERCA and PMCA pumps contribute to the deregulation of Ca(2+) homeostasis in human CF epithelial cells.

Réginald Philippe , Fabrice Antigny , Paul Buscaglia , Caroline Norez , Frédéric Becq et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 2015, 1853 (5), pp.892-903. ⟨10.1016/j.bbamcr.2015.01.010⟩
Article dans une revue hal-01134260 v1

A functional tandem between transient receptor potential canonical channels 6 and calcium-dependent chloride channels in human epithelial cells

Johanna Bertrand , Luc Dannhoffer , Fabrice Antigny , Laura Vachel , Christophe Jayle et al.
European Journal of Pharmacology, 2015, 765, pp.337-345. ⟨10.1016/j.ejphar.2015.08.005⟩
Article dans une revue hal-04541933 v1

Vasorelaxation induced by dodoneine is mediated by calcium channels blockade and carbonic anhydrase inhibition on vascular smooth muscle cells

Grégoire Carre , Maurice Ouedraogo , Christophe Magaud , Hélène Carreyre , Frédéric Becq et al.
Journal of Ethnopharmacology, 2015, 169, pp.8-17. ⟨10.1016/j.jep.2015.03.037⟩
Article dans une revue hal-04541937 v1
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Involvement of the Cdc42 Pathway in CFTR Post-Translational Turnover and in Its Plasma Membrane Stability in Airway Epithelial Cells

Romain Ferru-Clément , Fleur Fresquet , Caroline Norez , Thierry Métayé , Frédéric Becq et al.
PLoS ONE, 2015, 10, pp.e0118943. ⟨10.1371/journal.pone.0118943⟩
Article dans une revue hal-01141771 v1

Function, pharmacological correction and maturation of new Indian CFTR gene mutations

Himanshu Sharma , Mathilde Jollivet Souchet , Isabelle Callebaut , Rajendra Prasad , Frédéric Becq
Journal of Cystic Fibrosis, 2015, 14 (1), pp.34-41. ⟨10.1016/j.jcf.2014.06.008⟩
Article dans une revue hal-01099879 v1

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors

J. Désiré , M. Mondon , N. Fontelle , S. Nakagawa , Y. Hirokami et al.
Organic & Biomolecular Chemistry, 2014, 12 (44), pp.8977-8996. ⟨10.1039/c4ob00325j⟩
Article dans une revue hal-01311606 v1
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Cystic fibrosis bronchial epithelial cells are lipointoxicated by membrane palmitate accumulation

Laurie-Anne Payet , Linette Kadri , Sébastien Giraud , Caroline Norez , Jean Marc Berjeaud et al.
PLoS ONE, 2014, 9 (2), pp.e89044. ⟨10.1371/journal.pone.0089044⟩
Article dans une revue hal-00990346 v1

Bronchorelaxation of the human bronchi by CFTR activators

Caroline Norez , Christophe Jayle , Frédéric Becq , Clarisse Vandebrouck
Pulmonary Pharmacology and Therapeutics, 2014, 27 (1), pp.38-43. ⟨10.1016/j.pupt.2013.06.008⟩
Article dans une revue hal-04040435 v1
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Improvement of chloride transport defect by gonadotropin-releasing hormone (GnRH) in cystic fibrosis epithelial cells.

Nathalie Benz , Sophie Le Hir , Caroline Norez , Mathieu Kerbiriou , Marie-Laure Calvez et al.
PLoS ONE, 2014, 9 (2), pp.e88964. ⟨10.1371/journal.pone.0088964⟩
Article dans une revue hal-00990343 v1

The human CFTR protein expressed in CHO cells activates aquaporin-3 in a cAMP-dependent pathway: study by digital holographic microscopy.

Pascal Jourdain , Frédéric Becq , Sylvain Lengacher , Clément Boinot , Pierre J Magistretti et al.
Journal of Cell Science, 2014, 127 (Pt 3), pp.546-56. ⟨10.1242/jcs.133629⟩
Article dans une revue hal-00990312 v1

Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del-CFTR by a CDK-independent mechanism

C Norez , C. Vandebrouck , J Bertrand , S Noel , E Durieu et al.
British Journal of Pharmacology, 2014, 171 (21), pp.4831-4849. ⟨10.1111/bph.12859⟩
Article dans une revue hal-04041398 v1

The hypotensive agent dodoneine inhibits L-type Ca2+ current with negative inotropic effect on rat heart.

Grégoire Carré , Hélène Carreyre , Maurice Ouedraogo , Frédéric Becq , Patrick Bois et al.
European Journal of Pharmacology, 2014, 728, pp.119-27. ⟨10.1016/j.ejphar.2014.01.059⟩
Article dans une revue hal-00990335 v1

ANO1 contributes to angiotensin-II-activated Ca2+-dependent Cl- current in human atrial fibroblasts.

Antoun El Chemaly , Caroline Norez , Christophe Magaud , Jocelyn Bescond , Aurelien Chatelier et al.
Journal of Molecular and Cellular Cardiology, 2014, 68, pp.12-9. ⟨10.1016/j.yjmcc.2013.12.027⟩
Article dans une revue hal-00990329 v1

CFTR: Effect of ICL2 and ICL4 amino acids in close spatial proximity on the current properties of the channel

Arnaud Billet , Jean-Paul Mornon , Mathilde Jollivet , Pierre Lehn , Isabelle Callebaut et al.
Journal of Cystic Fibrosis, 2013, 12, pp.737-745. ⟨10.1016/j.jcf.2013.02.002⟩
Article dans une revue istex hal-00907930 v1

C-branched iminosugars: α-glucosidase inhibition by enantiomers of isoDMDP, isoDGDP, and isoDAB-L-isoDMDP compared to miglitol and miglustat.

Sarah F Jenkinson , Daniel Best , a Waldo Saville , James Mui , R Fernando Martínez et al.
Journal of Organic Chemistry, 2013, 78 (15), pp.7380-97. ⟨10.1021/jo4005487⟩
Article dans une revue hal-00990546 v1
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Strategies to circumvent the CFTR defect in cystic fibrosis.

Frédéric Becq , Marc Chanson
Frontiers in Pharmacology, 2013, 4, pp.108. ⟨10.3389/fphar.2013.00108⟩
Article dans une revue hal-00990355 v1

Rescue of functional CFTR channels in cystic fibrosis: a dramatic multivalent effect using iminosugar cluster-based correctors.

Philippe Compain , Camille Decroocq , Antoine Joosten , Julien de Sousa , David Rodríguez-Lucena et al.
ChemBioChem, 2013, 14 (15), pp.2050-8. ⟨10.1002/cbic.201300312⟩
Article dans une revue istex hal-00990168 v1

Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia.

Thassadite Dirami , Baptiste Rode , Mathilde Jollivet , Nathalie da Silva , Denise Escalier et al.
American Journal of Human Genetics, 2013, 92 (5), pp.760-6. ⟨10.1016/j.ajhg.2013.03.016⟩
Article dans une revue hal-00990664 v1

Saturated fatty acids alter the late secretory pathway by modulating membrane properties.

Laurie-Anne Payet , Ludovic Pineau , Ellen C R Snyder , Jenny Colas , Ahmed Moussa et al.
Traffic, 2013, 14 (12), pp.1228-41. ⟨10.1111/tra.12117⟩
Article dans une revue hal-00990166 v1
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Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain

Norbert Odolczyk , Janine Fritsch , Caroline Norez , Nathalie Servel , Melanie Faria da Cunha et al.
EMBO Molecular Medicine, 2013, 5 (10), pp.1484 - 1501. ⟨10.1002/emmm.201302699⟩
Article dans une revue hal-00990522 v1

Effect of VX-770 (ivacaftor) and OAG on Ca2+ influx and CFTR activity in G551D and F508del-CFTR expressing cells.

Laura Vachel , Caroline Norez , Frédéric Becq , Clarisse Vandebrouck
Journal of Cystic Fibrosis, 2013, 12 (6), pp.584-91. ⟨10.1016/j.jcf.2013.05.008⟩
Article dans une revue hal-00990531 v1

CFTR mutation combinations producing frequent complex alleles with different clinical and functional outcomes

Ayman El-Seedy , Emmanuelle Girodon , Caroline Norez , Julie Pajaud , Marie-Claude Pasquet et al.
Human Mutation, 2012, 33 (11), pp.1557-1565. ⟨10.1002/humu.22129⟩
Article dans une revue istex hal-02446189 v1
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Deficit of osteoprotegerin release by osteoblasts from a patient with cystic fibrosis.

Annelise Gimenez-Maitre , Carole Le Henaff , Caroline Norez , Christine Guillaume , Bruno Ravoninjatovo et al.
European Respiratory Journal, 2012, 39 (3), pp.780-1. ⟨10.1183/09031936.00104111⟩
Article dans une revue inserm-00602058 v1

From the vasodilator and hypotensive effects of an extract fraction from Agelanthus dodoneifolius (DC) Danser (Loranthaceae) to the active compound dodoneine

Maurice Ouedraogo , M. Ruiz , E. Vardelle , Hélène Carreyre , Jean-Marie Coustard et al.
Journal of Ethnopharmacology, 2011, 133 (2), pp.345-352. ⟨10.1016/j.jep.2010.10.002⟩
Article dans une revue istex hal-00560900 v1

Transient receptor potential canonical channel 6 links Ca2+ mishandling to cystic fibrosis transmembrane conductance regulator channel dysfunction in cystic fibrosis.

Fabrice Antigny , Caroline Norez , Luc Dannhoffer , Johanna Bertrand , Dorothée Raveau et al.
American Journal of Respiratory Cell and Molecular Biology, 2011, 44 (1), pp.83-90. ⟨10.1165/rcmb.2009-0347OC⟩
Article dans une revue hal-00559252 v1

An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors.

Brice-Loïc Renard , Benjamin Boucherle , Bruno Maurin , Marie-Carmen Molina , Caroline Norez et al.
European Journal of Medicinal Chemistry, 2011, 46 (5), pp.1935-41. ⟨10.1016/j.ejmech.2011.02.037⟩
Article dans une revue istex hal-00582439 v1
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CFTR and Ca2+ Signaling in Cystic Fibrosis

Fabrice Antigny , Caroline Norez , Frédéric Becq , Clarisse Vandebrouck
Frontiers in Pharmacology, 2011, 2, pp.67. ⟨10.3389/fphar.2011.00067⟩
Article dans une revue hal-00664651 v1

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain.

Nicolas Ardes-Guisot , Dominic S Alonzi , Gabriele Reinkensmeier , Terry D Butters , Caroline Norez et al.
Organic & Biomolecular Chemistry, 2011, 9 (15), pp.5373-5388. ⟨10.1039/c1ob05119a⟩
Article dans une revue hal-00608881 v1

Orphan Missense Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator

Fleur Fresquet , Romain Clement , Caroline Norez , Adélaïde Sterlin , Patricia Melin et al.
Journal of Molecular Diagnostics, 2011, 13 (5), pp.520-527. ⟨10.1016/j.jmoldx.2011.05.004⟩
Article dans une revue hal-04564655 v1
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Stimulation of wild-type, F508del- and G551D-CFTR chloride channels by non-toxic modified pyrrolo[2,3-b]pyrazine derivatives

Luc Dannhoffer , Arnaud Billet , Mathilde Jollivet-Souchet , Patricia Melin-Heschel , Christelle Faveau et al.
Frontiers in Pharmacology, 2011, 2, ⟨10.3389/fphar.2011.00048⟩
Article dans une revue hal-03192023 v1

4-C-Me-DAB and 4-C-Me-LAB - enantiomeric alkyl-branched pyrrolidine iminosugars - are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group.

Filipa P da Cruz , Scott Newberry , Sarah F Jenkinson , Mark R Wormald , Terry D Butters et al.
Tetrahedron Letters, 2011, 52 (2), pp.219-223. ⟨10.1016/j.tetlet.2010.10.173⟩
Article dans une revue hal-00580432 v1

CFTR channels and adenosine triphosphate release: the impossible rendez-vous revisited in skeletal muscle.

Frédéric Becq
The Journal of Physiology, 2010, 588 (Pt 23), pp.4605-6. ⟨10.1113/jphysiol.2010.200113⟩
Article dans une revue hal-00582430 v1

Cystic fibrosis and diabetes: isoLAB and isoDAB, enantiomeric carbon-branched pyrrolidine iminosugars

Daniel Best , Sarah F Jenkinson , Waldo A. Saville , Dominic S Alonzi , Mark R Wormald et al.
Tetrahedron Letters, 2010, 51 (32), pp.4170-4174. ⟨10.1016/j.tetlet.2010.05.131⟩
Article dans une revue istex hal-00580537 v1

Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia.

Ophélia Granio , Katherine J D Ashbourne Excoffon , Petra Henning , Patricia Melin , Caroline Norez et al.
Human Gene Therapy, 2010, 21 (3), pp.251-69. ⟨10.1089/hum.2009.056⟩
Article dans une revue hal-00580553 v1

Cystic fibrosis transmembrane conductance regulator modulators for personalized drug treatment of cystic fibrosis: progress to date.

Frédéric Becq
Drugs, 2010, 70 (3), pp.241-59. ⟨10.2165/11316160-000000000-00000⟩
Article dans une revue hal-00582426 v1
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C terminus of nucleotide binding domain 1 contains critical features for cystic fibrosis transmembrane conductance regulator trafficking and activation.

Arnaud Billet , Patricia Melin , Mathilde Jollivet , Jean-Paul Mornon , Isabelle Callebaut et al.
Journal of Biological Chemistry, 2010, 285 (29), pp.22132-40. ⟨10.1074/jbc.M110.120683⟩
Article dans une revue hal-00582442 v1

Understanding nucleotide binding and CFTR ion channel gating: how many cycles?

Frédéric Becq , Arnaud Billet
Expert Review of Respiratory Medicine, 2010, 4 (4), pp.451-4. ⟨10.1586/ers.10.47⟩
Article dans une revue hal-00561612 v1

Identification of a novel water-soluble activator of wild-type and F508del CFTR: GPact-11a.

J. Bertrand , B. Boucherle , A. Billet , P. Melin-Heschel , L. Dannhoffer et al.
European Respiratory Journal, 2010, 36 (2), pp.311-22. ⟨10.1183/09031936.00122509⟩
Article dans une revue hal-00559199 v1

Rescue of functional F508del cystic fibrosis transmembrane conductance regulator by vasoactive intestinal peptide in the human nasal epithelial cell line JME/CF15.

Sara Rafferty , Nicole Alcolado , Caroline Norez , Frederic Chappe , Siegried Pelzer et al.
Journal of Pharmacology and Experimental Therapeutics, 2009, 331 (1), pp.2-13
Article dans une revue hal-00444202 v1

A cystic fibrosis respiratory epithelial cell chronically treated by miglustat acquires a non-cystic fibrosis-like phenotype.

Caroline Norez , Fabrice Antigny , Sabrina Noel , Clarisse Vandebrouck , Frédéric Becq
American Journal of Respiratory Cell and Molecular Biology, 2009, 41 (2), pp.217-225. ⟨10.1165/rcmb.2008-0285OC⟩
Article dans une revue hal-00444213 v1

SiRNA calnexin promotes endogenous F508del-CFTR trafficking

D. Raveau , A. Cantereau , F. Becq , C. Norez
Journal of Cystic Fibrosis, 2009, 8, pp.S19. ⟨10.1016/S1569-1993(09)60078-3⟩
Article dans une revue hal-03119993 v1

Dysfunction of mitochondria Ca2+ uptake in cystic fibrosis airway epithelial cells

Fabrice Antigny , Nathalie Girardin , Dorothée Raveau , Maud Frieden , Frédéric Becq et al.
Mitochondrion, 2009, 9 (4), pp.232-241. ⟨10.1016/j.mito.2009.02.003⟩
Article dans une revue istex hal-04040455 v1

Anti-inflammatory effect of miglustat in bronchial epithelial cells

Maria Cristina Decheccchi , Elena Nicolis , Caroline Norez , Valentino Bezzerri , Monica Borgatti et al.
Journal of Cystic Fibrosis, 2008, 7 (6), pp.555-565. ⟨10.1016/j.jcf.2008.06.002⟩
Article dans une revue hal-00392599 v1

9-Phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels

Teddy Grand , Marie Demion , Caroline Norez , Yvette Mettey , Pierre Launay et al.
British Journal of Pharmacology, 2008, 153 (8), pp.1697-1705. ⟨10.1038/bjp.2008.38⟩
Article dans une revue hal-00393981 v1

Proteasome-Dependent Pharmacological Rescue of Cystic Fibrosis Transmembrane Conductance Regulator Revealed by Mutation of Glycine 622

Caroline Norez , Frédéric Bilan , Alain Kitzis , Yvette Mettey , Frédéric Becq
Journal of Pharmacology and Experimental Therapeutics, 2008, 25 (1), pp.89-99. ⟨10.1124/jpet.107.134502⟩
Article dans une revue hal-00392917 v1

Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells.

Frédéric Bilan , Magali Nacfer , Fleur Fresquet , Caroline Norez , Patricia Melin et al.
Experimental Cell Research, 2008, 314 (11-12), pp.2199-2211. ⟨10.1016/j.yexcr.2008.04.012⟩
Article dans une revue istex hal-00399077 v1

Guanabenz, an α2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cells

Caroline Norez , Clarisse Vandebrouck , Fabrice Antigny , Luc Dannhoffer , Marc Blondel et al.
European Journal of Pharmacology, 2008, 592 (1-3), pp.33-40. ⟨10.1016/j.ejphar.2008.06.103⟩
Article dans une revue istex hal-00392424 v1
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Abnormal spatial diffusion of Ca2+ in F508del-CFTR airway epithelial cells

Fabrice Antigny , Caroline Norez , Anne Cantereau , Frédéric Becq , Clarisse Vandebrouck
Respiratory Research, 2008, 9 (1), pp.70. ⟨10.1186/1465-9921-9-70⟩
Article dans une revue hal-03119859 v1

Stimulation of salivary secretion in vivo by CFTR potentiators in Cftr+/+ and Cftr−/− mice

Sabrina Noël , Pierre-Olivier Strale , Luc Dannhoffer , Martina Wilke , Hugo Dejonge et al.
Journal of Cystic Fibrosis, 2008, 7 (2), pp.128-133. ⟨10.1016/j.jcf.2007.06.005⟩
Article dans une revue hal-00402063 v1

Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis epithelial cells.

Sabrina Noël , Martina Wilke , Alice G. M. Bot , Hugo R. de Jonge , Frédéric Becq
Journal of Pharmacology and Experimental Therapeutics, 2008, 325 (1), pp.1016-1023. ⟨10.1124/jpet.107.135582⟩
Article dans une revue hal-00402085 v1

Transient receptor potential vanilloid 1 (TRPV1) channels in cultured rat Sertoli cells regulate an acid sensing chloride channel

Céline Auzanneau , Caroline Norez , Fabrice Antigny , Vincent Thoreau , Chantal Jougla et al.
Biochemical Pharmacology, 2007, 75 (2), pp.476-483. ⟨10.1016/j.bcp.2007.09.004⟩
Article dans une revue istex hal-00389815 v1

Structure Elucidation of a Dihydropyranone from Tapinanthus dodoneifolius

Maurice Ouedraogo , Hélène Carreyre , Clarisse Vandebrouck , Jocelyn Bescond , Guy Raymond et al.
Journal of Natural Products, 2007, 70 (12), pp.2006-2009
Article dans une revue hal-00389669 v1

Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries.

Robert Renaud , Jean Pierre Savineau , Caroline Norez , Frederic Becq , Christelle Guibert
European Respiratory Journal, 2007, ⟨10.1183/09031936.00060007⟩
Article dans une revue hal-02439706 v1

NHE-RF1 protein rescues DeltaF508-CFTR function

Florian Bossard , Amal Robay , Gilles Toumaniantz , Shehrazade Dahimene , Frédéric Becq et al.
American Journal of Physiology - Lung Cellular and Molecular Physiology, 2007, 292 (5), pp.1085-1094. ⟨10.1152/ajplung.00445.2005⟩
Article dans une revue hal-00401936 v1

Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR

Fabrice Antigny , Caroline Norez , Frédéric Becq , Clarisse Vandebrouck
Cell Calcium, 2007, 43 (2), pp.175-183. ⟨10.1016/j.ceca.2007.05.002⟩
Article dans une revue istex hal-00389764 v1

CFTR inhibition by glibenclamide requires a positive charge in cytoplasmic loop three

Patricia Melin , Eric Hosy , Michel Vivaudou , Frédéric Becq
Biochimica et Biophysica Acta:Biomembranes, 2007, 1768 (10), pp.2438-2446. ⟨10.1016/j.bbamem.2007.05.013⟩
Article dans une revue istex hal-00397837 v1

Cellular Localization and Activity of Ad-Delivered GFP-CFTR in Airway Epithelial and Tracheal Cells

Ophélia Granio , Caroline Norez , Katherine J.D. Ashbourne Excoffon , Philip H. Karp , Monika Lusky et al.
American Journal of Respiratory Cell and Molecular Biology, 2007, 37, pp.631-639. ⟨10.1165/rcmb.2007-0026TE⟩
Article dans une revue hal-00392684 v1

MPB-07 Reduces the Inflammatory Response to Pseudomonas aeruginosa in CF Bronchial Cells

Maria Cristina Dechecchi , Elena Nicolis , Valentino Bezzerri , Antonio Vella , Marco Colombatti et al.
American Journal of Respiratory Cell and Molecular Biology, 2007, 36 (5), pp.615-624. ⟨10.1165/rcmb.2006-0200OC⟩
Article dans une revue hal-00401637 v1

Discovery of alpha-aminoazaheterocycle-methylglyoxal adducts as a new class of high affinity inhibitors of CFTR chloride channels.

C. Routaboul , C. Norez , P. Melin , M.-C. Molina , B. Boucherle et al.
J. Pharmacol. Exp. Ther., 2007, pp.1023-1035. ⟨10.1124/jpet.107.123307⟩
Article dans une revue hal-00383202 v1

Pharmacological profile of inhibition of the chloride channels activated by extracellular acid in cultured rat Sertoli cells

Céline Auzanneau , Caroline Norez , Sabrina Noël , Chantal Jougla , Frédéric Becq et al.
Reproduction Nutrition Development, 2006, 46 (3), pp.241-255. ⟨10.1051/rnd:2006013⟩
Article dans une revue hal-04040482 v1

The Glycine Residues G551 and G1349 within the ATP-Binding Cassette Signature Motifs Play Critical Roles in the Activation and Inhibition of Cystic Fibrosis Transmembrane Conductance Regulator Channels by Phloxine B

Patricia Melin , Caroline Norez , Isabelle Callebaut , Frédéric Becq
Journal of Membrane Biology, 2006, 208, pp.203-212. ⟨10.1007/s00232-005-7001-0⟩
Article dans une revue istex hal-00113816 v1
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Pharmacological profile of inhibition of the chloride channels activated by extracellular acid in cultured rat Sertoli cells

Céline Auzanneau , Caroline Norez , Sabrina Noël , Chantal Jougla , Frédéric Becq et al.
Reproduction Nutrition Development, 2006, 46 (3), pp.241-255. ⟨10.1051/rnd:2006013⟩
Article dans une revue hal-00900616 v1
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Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation.

Clarisse Vandebrouck , Patricia Melin , Caroline Norez , Renaud Robert , Christelle Guibert et al.
Respiratory Research, 2006, 7 (1), pp.113. ⟨10.1186/1465-9921-7-113⟩
Article dans une revue inserm-00097884 v1

Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells

C. Norez , F. Antigny , F. Becq , C. Vandebrouck
Traffic, 2006, 7, pp.562-573. ⟨10.1111/j.1600-0854.2006.00409.x⟩
Article dans une revue hal-00078138 v1
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Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Channel by β-Adrenergic Agonists and Vasoactive Intestinal Peptide in Rat Smooth Muscle Cells and Its Role in Vasorelaxation

Renaud Robert , Vincent Thoreau , Caroline Norez , Anne Cantereau , Alain Kitzis et al.
Journal of Biological Chemistry, 2004, 279 (20), pp.21160-21168. ⟨10.1074/jbc.M312199200⟩
Article dans une revue hal-03120019 v1
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Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity

Frédéric Bilan , Vincent Thoreau , Magali Nacfer , Renaud Derand , Caroline Norez et al.
Journal of Cell Science, 2004, 117 (10), pp.1923 - 1935. ⟨10.1242/jcs.01070⟩
Article dans une revue hal-03119932 v1

General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels.

B. Marcet , F. Becq , C. Norez , P. Delmas , Bernard Verrier
British Journal of Pharmacology, 2004, 919, pp.919
Article dans une revue hal-00143529 v1

The cystic fibrosis mutation G1349D within the signature motif LSHGH of NBD2 abolishes the activation of CFTR chloride channels by genistein

Patricia Melin , Vincent Thoreau , Caroline Norez , Frédéric Bilan , Alain Kitzis et al.
Biochemical Pharmacology, 2004, 67 (12), pp.2187-2196. ⟨10.1016/j.bcp.2004.02.022⟩
Article dans une revue istex hal-04564678 v1

Synthesis, SAR, Crystal Structure, and Biological Evaluation of Benzoquinoliziniums as Activators of Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Channels

Cécile Marivingt-Mounir , Caroline Norez , Renaud Dérand , Laurence Bulteau-Pignoux , Dung Nguyen-Huy et al.
Journal of Medicinal Chemistry, 2004, 47 (4), pp.962-972. ⟨10.1021/jm0308848⟩
Article dans une revue istex hal-03610137 v1

A Novel Voltage-dependent Chloride Current Activated by Extracellular Acidic pH in Cultured Rat Sertoli Cells

Céline Auzanneau , Vincent Thoreau , Alain Kitzis , Frédéric Becq
Journal of Biological Chemistry, 2003, 278 (21), pp.19230-19236. ⟨10.1074/jbc.M301096200⟩
Article dans une revue hal-04564683 v1

Cystic fibrosis transmembrane conductance regulator (CFTR) confers glibenclamide sensivity to outwardly rectifying chloride channel (ORCC) in Hi-5 insect cells

Marie-Pierre Julien , B. Verrier , M. Cerutti , V. Chappe , M. Gola et al.
Journal of Membrane Biology, 1999, 168 (3), pp.229-239. ⟨10.1007/s002329900512⟩
Article dans une revue istex hal-02698653 v1

Acute effects of adenosine triphosphates, cyclic 3 ',5 '-adenosine monophosphates, and follicle-stimulating hormone on cytosolic calcium level in cultured immature rat Sertoli cells

Nathalie Lalevee , C. Rogier , F. Becq , M. Joffre
Biology of Reproduction, 1999, 61 (2), pp.343-352. ⟨10.1095/biolreprod61.2.343⟩
Article dans une revue hal-01619070 v1

Impact of hypoxia in Cystic Fibrosis bronchial epithelial cells: Focus on CFTR and TRPA1 channels

Khilian Pascarel , Jenny Colas , Thomas Carrez , Sandra Mirval , Christine Barrault et al.
19es Journées de Recherche Respiratoire (J2R 2023), Groupe RESPIRenT (RESeau de Pneumologie en Innovation et Recherche translaTionnelle) de la Société de pneumologie de langue française (SPLF), Oct 2023, Paris, France. pp.226, ⟨10.1016/j.rmr.2024.01.089⟩
Communication dans un congrès hal-04828420 v1

Développement d'un modèle d'infection respiratoire aiguë à Pseudomonas aeruginosa chez le porc

Mickaël Riou , Claire C. Chevaleyre , Deborah Brea , Celine Barc , Clarisse Vandebrouck et al.
34. Réunion Interdisciplinaire de Chimiothérapie Anti-Infectieuse (RICAI), Nov 2014, Paris, France
Communication dans un congrès hal-02799765 v1

Toute une histoire...

Nadine Pellen , Frédéric Becq
2012, http://www.mucoviscidose-cftr.com/2012/05/28/toute-une-histoire
Article de blog scientifique hal-02165663 v1

Compounds for treating cystic fibrosis

Isabelle Callebaut , Jean-Paul Mornon , Jean-Luc Decout , F. Becq , Pierre Lehn et al.
France, Patent n° : US10414768B2. 2019
Brevet hal-04768593 v1

Utilisation de dérivés des benzo(c)quinoliziniums pour le traitement des pathologies liées aux phénomènes de constriction des cellules musculaires lisses

Frédéric Becq , Renaud Robert , Laurence Pignoux , Christian Rogier , Yvette Mettey et al.
France, N° de brevet: EP 1 509 520 B1. 2006
Brevet hal-05016386 v1

Use of benzo(c)quinolizinium derivatives for the treatment of diseases that are linked to smooth muscle cell constriction

Frédéric Becq , Renaud Robert , Laurence Pignoux , Christian Rogier , Yvette Mettey et al.
France, Patent n° : US 20050176747A1. 2005
Brevet hal-05016399 v1

Utilisation de dérivés de pyrrolo-pyrazines pour la fabrication de médicaments pour le traitement de la mucoviscidose et de la maladies liées a un défaut d'adressage des protéines dans les cellules.

F. Becq , L. Meijer , Y. Mettey
Patent n° : FR04 10 962. 2004
Brevet hal-00020544 v1

Utilisations de la kenpaullone pour une thérapie de la mucoviscidose.

F. Becq , L. Meijer , C. Kunick
Patent n° : FR04 10961. 2004
Brevet hal-00020546 v1

Utilisations de dérivés de purines pour la fabrication de médicaments pour le traitement de la mucoviscidose et de maladies liées a un défaut d'adressage des protéines dans les cellules

F. Becq , L. Meijer
Patent n° : FR 04 10 958. 2004
Brevet hal-00020556 v1

Zwitterion CFTR channel modulators, preparation, pharmaceutical compositions, and therapeuthic use

Jean Luc Decout , C. Routaboul , F. Becq , C. Norez
Patent n° : FR 2861304, US 20060258612, WO 2005039589. 2003
Brevet hal-00383682 v1