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Frédéric Leroux

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Documents

Presentation

Frederic Leroux obtained a PhD in chemistry at the University of Konstanz (Germany), under the supervision of Prof. H. Fischer. In 1998, he moved to a postdoctoral position with Prof. M. Schlosser at the University of Lausanne (Switzerland) and accepted the same year a position of Assistant Professor. In 2001 he moved then to the Swiss Federal Institute of Technology in Lausanne (EPFL). He started his independent research career in 2003 as CNRS Research Associate at the University of Strasbourg (France). He obtained his habilitation in 2005 and was promoted CNRS Research Director in 2009. Frederic Leroux is presently the director of the molecular chemistry department “Laboratoire d’Innovation Moléculaire et Applications” UMR CNRS 7042-LIMA of the Université de Strasbourg, Université de Haute-Alsace and the CNRS (lima.unistra.fr) and director of the joint CNRS-Bayer-Université de Strasbourg laboratory on organofluorine chemistry. His research (coha.unistra.fr) is published in >120 peer-reviewed publications, 18 patents, 11 books and book chapters and presented by invitation at >80 (inter)national conferences. He is Fellow of the Royal Society of Chemistry (FRSC) and member of the European Academy of Sciences and Arts. He is also a member of the International Scientific Committee of the Moissan Prize (Fluorine Chemistry), Director of the French Fluorine Network ([http://www.reseau-fluor.fr](http://www.reseau-fluor.fr/)) and President of the French-Japanese Society of Medicinal and Fine Chemistry (fjs.crihan.fr). The philosophy of his research is based on a fruitful interplay of several objectives (a) the synthesis of biologically relevant molecules, (b) asymmetric methodologies using organic and organometallic chemistry, (c) organofluorine chemistry and (d) application of the objectives to industrial problems, which led to strong industrial collaborations. The discovery of new and mild methodologies to introduce fluorine atoms or emergent fluorinated groups (OCF3, CHF2, ...) onto heterocycles as well as their stereoselective introduction onto Csp3-centers is a key topic of his research and developed in close collaboration with industry.

Publications

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Direct Deprotonative Functionalization of α,α‐Difluoromethyl Ketones using a Catalytic Organosuperbase

Amélia Messara , Armen Panossian , Koichi Mikami , Gilles Hanquet , Frederic Leroux et al.
Angewandte Chemie International Edition, inPress, ⟨10.1002/anie.202215899⟩
Journal articles hal-03933942v1
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Study of Carbamoyl Fluoride: Synthesis, Properties and Applications

Clémence Bonnefoy , Emmanuel Chefdeville , Christian Tourvieille , Armen Panossian , Gilles Hanquet et al.
Chemistry - A European Journal, 2022, 28 (43), ⟨10.1002/chem.202201589⟩
Journal articles hal-03744602v1
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Palladium‐Catalyzed Silylcyanation of Ynamides: Regio‐ and Stereoselective Access to Tetrasubstituted 3‐Silyl‐2‐Aminoacrylonitriles

Pierre Hansjacob , Frédéric R. Leroux , Vincent Gandon , Morgan Donnard
Angewandte Chemie International Edition, 2022, ⟨10.1002/anie.202200204⟩
Journal articles hal-03541070v1
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One‐step Oxidative Monofluorination of Electron‐deficient Sulfoxides to Access Highly Lewis Acidic Sulfur(VI) Cations

Jordan Berreur , Alberto Diez-Varga , Augustin Manel , Frédéric Leroux , Armen Panossian et al.
Chemistry - A European Journal, 2022, ⟨10.1002/chem.202202564⟩
Journal articles hal-03795951v1
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Direct Access to 2,3-Disubstituted Amido-Indenones through Annulation of 2-Iodobenzaldehydes with Ynamides

Stéphane Golling , Pierre Hansjacob , Nassim Bami , Frédéric R Leroux , Morgan Donnard et al.
The Journal of Organic Chemistry, 2022, ⟨10.1021/acs.joc.2c02054⟩
Journal articles hal-03883448v1
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(NHC-olefin)-nickel(0) nanoparticles as catalysts for the (Z)-selective semi-hydrogenation of alkynes and ynamides

Marta Avello , Stéphane Golling , Lai Truong-Phuoc , Loic Vidal , Thierry Romero et al.
Chemical Communications, 2022, ⟨10.1039/D2CC05302K⟩
Journal articles hal-03909675v1
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Ketenimines as Intermediates To Access Difluoromethoxylated Scaffolds

Anaïs Loison , Gilles Hanquet , Fabien Toulgoat , Thierry Billard , Armen Panossian et al.
Organic Letters, 2022, ⟨10.1021/acs.orglett.2c03283⟩
Journal articles hal-03843401v1
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Versatile Access to Tetrasubstituted 2-Amidoacroleins through Formal Silylformylation of Ynamides

Stéphane Golling , Frédéric R. Leroux , Morgan Donnard
Organic Letters, 2021, 23, pp.8093-8097. ⟨10.1021/acs.orglett.1c03141⟩
Journal articles hal-03369636v1
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Formation of synthetically relevant CF 3 -substituted phenonium ions in superacid media †

Anthony Fernandes , Bastien Michelet , Armen Panossian , Agnès Martin-Mingot , Frédéric R Leroux et al.
RSC Advances, 2021, 11 (41), pp.25695-25699. ⟨10.1039/d1ra04901a⟩
Journal articles hal-03358403v1
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SO2F2-Mediated N-Alkylation of Imino-Thiazolidinones

Laura Santos , Morgan Donnard , Armen Panossian , Jean-Pierre Vors , Peter Jeschke et al.
Journal of Organic Chemistry, inPress, ⟨10.1021/acs.joc.1c01247⟩
Journal articles hal-03325274v1
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Recent synthetic methods towards the –OCHF2 moiety

Anaïs Loison , Fabien Toulgoat , Thierry Billard , Gilles Hanquet , Armen Panossian et al.
Tetrahedron, 2021, 99, pp.132458. ⟨10.1016/j.tet.2021.132458⟩
Journal articles hal-03517915v1
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CF -substituted carbocations: underexploited intermediates with great potential in modern synthetic chemistry

Anthony J Fernandes , Armen Panossian , Bastien Michelet , Agnès Martin-Mingot , Frédéric Leroux et al.
Beilstein Journal of Organic Chemistry, 2021, 17, pp.343-378. ⟨10.3762/bjoc.17.32⟩
Journal articles hal-03154651v1
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Electrophilic fluorosulfoxonium cations as hidden Brønsted acid catalysts in (n+2) annulations of strained cycloalkanes

Augustin Manel , Jordan Berreur , Frédéric R. Leroux , Armen Panossian
Organic Chemistry Frontiers, inPress, ⟨10.1039/D1QO00840D⟩
Journal articles hal-03325336v1
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Direct trifluoromethoxylation without OCF3 ‐carrier via in‐situ generation of fluorophosgene

Jérémy Saiter , Thomas Guérin , Morgan Donnard , Armen Panossian , Gilles Hanquet et al.
European Journal of Organic Chemistry, 2021, 2021 (22), ⟨10.1002/ejoc.202100429⟩
Journal articles hal-03228836v1
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The winding road towards an atropo-enantioselective 'ARYNE coupling'

David Augros , Corinne Comoy , Yves Fort , Frédéric Leroux , Armen Panossian et al.
European Journal of Organic Chemistry, 2021, ⟨10.1002/ejoc.202100087⟩
Journal articles hal-03170152v1
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Formation of synthetically relevant CF3-substituted phenonium ions in superacid media

Anthony J Fernandes , Bastien Michelet , Armen Panossian , Agnès Martin-Mingot , Frédéric R. Leroux et al.
RSC Advances, 2021, 11 (41), pp.25695 - 25699. ⟨10.1039/d1ra04901a⟩
Journal articles hal-03325280v1
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Synthesis of 3-Amino-5-fluoroalkylfurans by Intramolecular Cyclization

Clotilde Plaçais , Morgan Donnard , Armen Panossian , Jean-Pierre Vors , David Bernier et al.
Organic Letters, 2021, 23 (12), pp.4915-4919. ⟨10.1021/acs.orglett.1c01672⟩
Journal articles hal-03325240v1
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Practical Synthesis and Application of Halogen-Doped Pyrrole Building Blocks

Andrej Emanuel Cotman , Thomas Guérin , Ivana Kovačević , Davide Benedetto Tiz , Martina Durcik et al.
ACS Omega, 2021, 6 (14), pp.9723-9730. ⟨10.1021/acsomega.1c00331⟩
Journal articles hal-03228819v1
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Aryl Fluoroalkyl Sulfoxides: Optical Stability and p K a Measurement

Amélia Messara , Nicolas Vanthuyne , Patrick Diter , Mourad Elhabiri , Armen Panossian et al.
European Journal of Organic Chemistry, 2021, 2021 (36), ⟨10.1002/ejoc.202100816⟩
Journal articles hal-03319682v1
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Study of a Stable “Trifluoromethoxide Anion Solution” Arising from 2,4‐Dinitro‐Trifluoromethoxybenzene

Clémence Bonnefoy , Emmanuel Chefdeville , Armen Panossian , Gilles Hanquet , Frédéric R. Leroux et al.
Chemistry - A European Journal, 2021, 27 (64), pp.15986-15991. ⟨10.1002/chem.202102809⟩
Journal articles hal-03582991v1
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Deprotonative Functionalization of the Difluoromethyl Group

Laura Santos , Armen Panossian , Morgan Donnard , Jean-Pierre Vors , Sergii Pazenok et al.
Organic Letters, 2020, ⟨10.1021/acs.orglett.0c03380⟩
Journal articles hal-02989088v1
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Synthesis and Use of Trifluoromethylthiolated Ketenimines

Frédéric R. Leroux , Thomas Guérin , Nadiia Pikun , Ryutaro Morioka , Armen Panossian et al.
Chemistry - A European Journal, 2020, ⟨10.1002/chem.202002723⟩
Journal articles hal-02990038v1

Transition-Metal-Free Approach for the Direct Arylation of Thiophene: Experimental and Theoretical Investigations towards the (Het)-Aryne Route

Catherine Demangeat , Tarak Saied , Romain Ramozzi , Francesca Ingrosso , Manuel Ruiz-Lopez et al.
European Journal of Organic Chemistry, 2019, 2019 (2-3), pp.547-556. ⟨10.1002/ejoc.201801173⟩
Journal articles hal-02186820v1
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Transition-Metal-Free Heterobiaryl Synthesis via Aryne Coupling

Tarak Saied , Catherine Demangeat , Armen Panossian , Frédéric Leroux , Yves Fort et al.
European Journal of Organic Chemistry, 2019, 2019 (31-32), pp.5275-5284. ⟨10.1002/ejoc.201900130⟩
Journal articles hal-02186792v1
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Efficient asymmetric synthesis of aryl difluoromethyl sulfoxides and their use to access enantiopure α-difluoromethyl alcohols

Chloé Batisse , Maria Cespedes Davila , Marco Castello , Amélia Messara , Bertrand Vivet et al.
Tetrahedron, 2019, 75 (23), pp.3063-3079. ⟨10.1016/j.tet.2019.04.037⟩
Journal articles hal-02400108v1
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Access towards enantiopure α,α-difluoromethyl alcohols by means of sulfoxides as traceless chiral auxiliaries

Chloé Batisse , Armen Panossian , Gilles Hanquet , Frédéric Leroux
Chemical Communications, 2018, 54 (74), pp.10423-10426. ⟨10.1039/C8CC05571H⟩
Journal articles hal-02150060v1

A physico-chemical investigation of fluorine-enriched quinolines

F. Aribi , A. Panossian , D. Jacquemin , J.-P. Vors , S. Pazenok et al.
New Journal of Chemistry, 2018, 42 (12), pp.10036-10047. ⟨10.1039/c8nj00916c⟩
Journal articles hal-02105499v1

Stereoselectivity Switch in the Trapping of Polar Organometallics with Andersen’s Reagent—Access to Highly Stereoenriched Transformable Biphenyls

J. Bortoluzzi , V. Jha , G. Levitre , M. J. Fer , J. Berreur et al.
Journal of Organic Chemistry, 2018, 83 (15), pp.7751-7761. ⟨10.1021/acs.joc.8b00648⟩
Journal articles hal-02105503v1

A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation

T. Naret , J. Bignon , G. Bernadat , M. Benchekroun , H. Levaique et al.
European Journal of Medicinal Chemistry, 2018, 143, pp.473-490. ⟨10.1016/j.ejmech.2017.11.055⟩
Journal articles hal-02105508v1
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Synthesis of Mono- and Bis(fluoroalkyl)pyrimidines from FARs, Fluorinated Acetoacetates, and Malononitrile Provides Easy Access to Novel High-Value Pyrimidine Scaffolds

E. Schmitt , B. Commare , A. Panossian , J.-P. Vors , S. Pazenok et al.
Chemistry - A European Journal, 2018, 24 (6), pp.1311-1316. ⟨10.1002/chem.201703982⟩
Journal articles hal-02105509v1
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Tri- and difluoromethoxylated N-based heterocycles − Synthesis and insecticidal activity of novel F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid

Grégory Landelle , Etienne Schmitt , Armen Panossian , Jean-Pierre Vors , Sergiy Pazenok et al.
Journal of Fluorine Chemistry, 2017, 203, pp.155-165. ⟨10.1016/j.jfluchem.2017.08.006⟩
Journal articles hal-02105310v1
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Control of axial chirality in absence of transition metals based on arynes

Frédéric R. Leroux , Armen Panossian , David Augros
Comptes Rendus. Chimie, 2017, 20 (6), pp.682-692. ⟨10.1016/j.crci.2016.12.001⟩
Journal articles hal-02105315v1
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Fluoroalkyl Amino Reagents for the Introduction of the Fluoro(trifluoromethoxy)methyl Group onto Arenes and Heterocycles

Etienne Schmitt , Sebastien Bouvet , Bruce Pegot , Armen Panossian , Jean-Pierre Vors et al.
Organic Letters, 2017, 19 (18), pp.4960-4963. ⟨10.1021/acs.orglett.7b02444⟩
Journal articles hal-02105321v1

Fluoroalkyl Amino Reagents (FARs): A General Approach towards the Synthesis of Heterocyclic Compounds Bearing Emergent Fluorinated Substituents

Frédéric R. Leroux , Bruno Commare , Etienne Schmitt , Fallia Aribi , Armen Panossian et al.
Molecules, 2017, 22 (6), pp.977. ⟨10.3390/molecules22060977⟩
Journal articles hal-02105792v1

Switchable Diastereoselectivity in the Fluoride-Promoted Vinylogous Mukaiyama–Michael Reaction of 2-[(Trimethylsilyl)oxy]furan Catalyzed by Crown Ethers

Frédéric R. Leroux , Giorgio Della Sala , Marina Sicignano , Rosaria Schettini , Francesco de Riccardis et al.
Journal of Organic Chemistry, 2017, 82 (13), pp.6629-6637. ⟨10.1021/acs.joc.7b00743⟩
Journal articles hal-02105791v1

Asymmetric α-Sulfonyl- and α-Phosphoryl-Oxylation of Ketones by a Chiral Hypervalent Iodine(III)

Guillaume Levitre , Audrey Dumoulin , Pascal Retailleau , Armen Panossian , Frederic R. Leroux et al.
Journal of Organic Chemistry, 2017, 82 (22), pp.11877-11883. ⟨10.1021/acs.joc.7b01597⟩
Journal articles hal-02105318v1
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Transition-Metal-Free Synthesis of a Known Intermediate in the Formal Synthesis of (-)-Steganacin

David Augros , Boubacar Yalcouye , Sabine Choppin , Matthieu Chessé , Armen Panossian et al.
European Journal of Organic Chemistry, 2017, 2017 (3), pp.497-503. ⟨10.1002/ejoc.201601239⟩
Journal articles hal-02105793v1

Switchable Diastereoselectivity in the Fluoride-Promoted Vinylogous Mukaiyama–Michael Reaction of 2-[(Trimethylsilyl)oxy]furan Catalyzed by Crown Ethers

Giorgio Della Sala , Marina Sicignano , Rosaria Schettini , Francesco de Riccardis , Luigi Cavallo et al.
Journal of Organic Chemistry, 2017, 82 (13), pp.6629-6637. ⟨10.1021/acs.joc.7b00743⟩
Journal articles hal-03054554v1

Lithium/Element Exchange as an Efficient Tool for Accessing Atropo-enriched Biaryls via Arynes

Frédéric R. Leroux , Armen Panossian , Frédéric Leroux
CHIMIA, 2016, 70 (1), pp.43-47. ⟨10.2533/chimia.2016.43⟩
Journal articles hal-03004175v1

A Major Advance in the Synthesis of Fluoroalkyl Pyrazoles: Tuneable Regioselectivity and Broad Substitution Patterns

Frédéric R. Leroux , Etienne Schmitt , Armen Panossian , Jean-Pierre Vors , Christian Funke et al.
Chemistry - A European Journal, 2016, 22 (32), pp.11239-11244. ⟨10.1002/chem.201601621⟩
Journal articles hal-03004108v1

When Chirality Meets “Buchwald-Type” Phosphines: Synthesis and Evaluation in Frustrated Lewis Pair-, Lewis Base- and Palladium-Promoted Asymmetric Catalysis

Frédéric R. Leroux , Mickaël Fer , Joséphine Cinqualbre , Julien Bortoluzzi , Matthieu Chessé et al.
European Journal of Organic Chemistry, 2016, 2016 (26), pp.4545-4553. ⟨10.1002/ejoc.201600727⟩
Journal articles hal-03004119v1

Access to Atropisomerically Enriched Biaryls by the Coupling of Aryllithiums with Arynes under Control by Homochiral Oxazolines

Boubacar Yalcouye , Anaïs Brehier , David Augros , Armen Panossian , Sabine Choppin et al.
European Journal of Organic Chemistry, 2016, 2016 (4), pp.725-732. ⟨10.1002/ejoc.201501503⟩
Journal articles hal-02304102v1

Atropo-diastereoselective coupling of aryllithiums and arynes — variations around the chiral auxiliary

Frédéric R. Leroux , David Augros , Boubacar Yalcouye , Anaïs Berthelot-Bréhier , Matthieu Chessé et al.
Tetrahedron, 2016, 72 (34), pp.5208-5220. ⟨10.1016/j.tet.2016.01.047⟩
Journal articles hal-03004140v1
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A new approach toward the synthesis of 2,4-bis(fluoroalkyl)-substituted quinoline derivatives using fluoroalkyl amino reagent chemistry

Fallia Aribi , Etienne Schmitt , Armen Panossian , Jean-Pierre Vors , Sergiy Pazenok et al.
Organic Chemistry Frontiers, 2016, 3 (11), pp.1392-1415. ⟨10.1039/C6QO00319B⟩
Journal articles hal-03004130v1

Asymmetric Bromine-Lithium Exchange: Application toward the Synthesis of New Biaryl-Diphosphine Ligands

Frédéric R. Leroux , Julien Graff , Elżbieta Łastawiecka , Laure Guénée , Frédéric Leroux et al.
Advanced Synthesis and Catalysis, 2015, 357 (13), pp.2833-2839. ⟨10.1002/adsc.201500323⟩
Journal articles hal-03004211v1

Atroposelective synthesis of axially chiral P,S-ligands based on arynes

Anais Berthelot-Brehier , Armen Panossian , Francoise Colobert-Leuenberger , Frédéric Leroux
Organic Chemistry Frontiers, 2015, 2 (6), pp.634-644. ⟨10.1039/C5QO00067J⟩
Journal articles hal-02306240v1

Determination of the absolute configuration of phosphinic analogues of glutamate

Bruno Commare , Delphine Rigault , Isabelle Lemasson , Patrick Deschamps , Alain Tomas et al.
Organic & Biomolecular Chemistry, 2015, 13 (4), pp.1106-1112. ⟨10.1039/C4OB01960A⟩
Journal articles hal-02268872v1

In Situ Generated Fluorinated Iminium Salts for Difluoromethylation and Difluoroacetylation

Frédéric R. Leroux , Etienne Schmitt , Baptiste Rugeri , Armen Panossian , Jean-Pierre Vors et al.
Organic Letters, 2015, 17 (18), pp.4510-4513. ⟨10.1021/acs.orglett.5b02184⟩
Journal articles hal-03004193v1

Modular Synthesis of Biaryl-Substituted Phosphine Ligands: Application in Microwave-Assisted Palladium-Catalyzed C-N Cross-Coupling Reactions

Chandani Singh , Jayant Rathod , Vishwajeet Jha , Armen Panossian , Pradeep Kumar et al.
European Journal of Organic Chemistry, 2015, 2015 (29), pp.6515-6525. ⟨10.1002/ejoc.201500962⟩
Journal articles hal-02304103v1

Recent advances and new concepts for the synthesis of axially stereoenriched biaryls

Joanna Wencel‐delord , Armen Panossian , Frédéric Leroux , Françoise Colobert
Chemical Society Reviews, inPress, ⟨10.1039/c5cs00012b⟩
Journal articles hal-02305225v1

Substituent effects on the relative rates and free energies of ortho-lithiation reactions: families of fluorobenzenes as the substrates

F Mongin , C Curty , E Marzi , Frédéric Leroux , M Schlosser et al.
ARKIVOC - Online Journal of Organic Chemistry, 2015, 4, pp.48-65. ⟨10.3998/ark.5550190.p008.926⟩
Journal articles hal-02304104v1

Unusual phosphine oxidation: new triazolopyridyl-quinolyl phosphine oxide fluorescent dyes

R. Ballesteros-Garrido , B. Abarca , R. Ballesteros , F. Colobert , Frédéric R. Leroux et al.
RSC Advances, 2015, 5 (38), pp.29809-29813. ⟨10.1039/C5RA04386G⟩
Journal articles hal-03004215v1

Synthesis and biological evaluation of new nucleosides derived from trifluoromethoxy-4-quinolones

Kristína Plevová , Katarína Briestenská , Francoise Colobert-Leuenberger , Jela Mistríková , Viktor Milata et al.
Tetrahedron Letters, 2015, 56 (36), pp.5112-5115. ⟨10.1016/j.tetlet.2015.07.031⟩
Journal articles hal-02305222v1

Multi-nuclear NMR of axially chiral biaryls in polypeptide orienting solvents: spectral discriminations and enantiorecognition mechanisms

Philippe Berdagué , Jose-Enrique Herbert-Pucheta , Vishwajeet Jha , Armen Panossian , Frédéric Leroux et al.
New Journal of Chemistry, 2015, 39 (12), pp.9504-9517. ⟨10.1039/c5nj01434d⟩
Journal articles hal-02314357v1

A General Approach towards NH-Pyrazoles That Bear Diverse Fluoroalkyl Groups by Means of Fluorinated Iminium Salts

Étienne Schmitt , Gregory Landelle , Jean-Pierre Vors , Norbert Lui , Sergiy Pazenok et al.
European Journal of Organic Chemistry, 2015, 27, pp.6052-6060. ⟨10.1002/ejoc.201500920⟩
Journal articles hal-02305226v1

Tribute to Prof. Manfred Schlosser (1934-2013) Obituary

Renzo Ruzziconi , Frédéric Leroux
Journal of Fluorine Chemistry, 2015, 171, pp.2-3. ⟨10.1016/j.jfluchem.2014.09.014⟩
Journal articles hal-02304109v1

A theoretical and experimental study of the racemization process of hexaaza[5]helicenes

Belen Abarca , Rafael Ballesteros , Rosa Adam , Rafael Ballesteros-Garrido , Frédéric Leroux et al.
Tetrahedron, 2014, 70 (45), pp.8750-8757. ⟨10.1016/j.tet.2014.09.018⟩
Journal articles hal-02307797v1

Novel C1-symmetric dibenzophosphole ligands: application in hydroformylation reactions

Abdelouahd Oukhrib , Laurence Bonnafoux , Armen Panossian , Sandrine Waifang , Duc Hanh Nguyen et al.
Tetrahedron, 2014, 70 (7), pp.1431-1436. ⟨10.1016/j.tet.2014.01.003⟩
Journal articles hal-00992450v1

Fluorine Chemistry Special Feature

Frédéric Leroux , Mark Ford , Sergiy Pazenok
Organic Process Research and Development, 2014, 18 (8), ⟨10.1021/op500216s⟩
Journal articles hal-02306238v1

Trifluoromethyl Ethers and -Thioethers as Tools for Medicinal Chemistry and Drug Discovery

Gregory Landelle , Armen Panossian , Frédéric Leroux
Current Topics in Medicinal Chemistry, 2014, 14 (7), pp.941-951
Journal articles hal-02306242v1

A New Synthesis and Process Development of Bis(fluoroalkyl)pyrazoles As Novel Agrophores

F Giornal , G Landelle , N Lui , J Vors , S Pazenok et al.
Organic Process Research and Development, 2014, 18 (8), pp.1002-1009. ⟨10.1021/Op500102h⟩
Journal articles hal-02342504v1

A concise atroposelective formal synthesis of (-)-steganone

Boubacar Yalcouye , Sabine Choppin , Armen Panossian , Frédéric Leroux , Francoise Colobert-Leuenberger et al.
European Journal of Organic Chemistry, 2014, 2014 (28), pp.6285-6294. ⟨10.1002/ejoc.201402761⟩
Journal articles hal-02304105v1

Palladium-Catalyzed Intramolecular Direct Arylation of 2-Bromo-diaryl Sulfoxides via C-H Bond Activation

Thomas Wesch , Anaïs Brehier , Frédéric Leroux , Francoise Colobert-Leuenberger
Organic Letters, 2013, 15 (10), pp.2490-2493. ⟨10.1021/ol400966q⟩
Journal articles hal-02304107v1

Convenient and Reliable Routes Towards 2-Aminothiazoles: Palladium-Catalyzed versus Copper-Catalyzed Aminations of Halothiazoles

Stéphanie Toulot , Timo Heinrich , Frédéric Leroux
Advanced Synthesis and Catalysis, 2013, 355 (16), pp.3263-3272. ⟨10.1002/adsc.201300591⟩
Journal articles hal-02342506v1

Recent advances in transition metal-catalyzed Csp(2)-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation

Gregory Landelle , Armen Panossian , Sergiy Pazenok , Jean-Pierre Vors , Frédéric Leroux et al.
Beilstein Journal of Organic Chemistry, 2013, 9, pp.2476-2536. ⟨10.3762/bjoc.9.287⟩
Journal articles hal-02304098v1

Synthesis and structural properties of hexaaza[5]helicene containing two [1,2,3]triazolo[1,5-a]pyridine moieties

Rosa Adam , Rafael Ballesteros-Garrido , Oriol Vallcorba , Belen Abarca , Rafael Ballesteros et al.
Tetrahedron Letters, 2013, 54 (32), pp.4316-4319. ⟨10.1016/j.tetlet.2013.06.014⟩
Journal articles hal-02306243v1

Manfred Schlosser (1934-2013) Obituary

Frédéric Leroux
Angewandte Chemie International Edition, 2013, 52 (48), ⟨10.1002/anie.201308231⟩
Journal articles hal-02307800v1

A New Life for an Old Reagent: Fluoroalkyl Amino Reagents as Efficient Tools for the Synthesis of Diversely Fluorinated Pyrazoles

Frédéric R. Leroux , Sergiy Pazenok , Florence Giornal , Grégory Landelle , Norbert Lui et al.
European Journal of Organic Chemistry, 2013, 2013 (20), pp.4249-4253. ⟨10.1002/ejoc.201300561⟩
Journal articles hal-03004227v1

Synthesis of diversely fluorinated pyrazoles as novel active agrochemical ingredients

Florence Giornal , Lars Rodefeld , Norbert Lui , Jean-Pierre Vors , Frédéric Leroux et al.
Journal of Fluorine Chemistry, 2013, 152, pp.2-11. ⟨10.1016/j.jfluchem.2012.11.008⟩
Journal articles hal-02307799v1

Atropodiastereoselective C-H Olefination of Biphenyl p-Tolyl Sulfoxides with Acrylates

Thomas Wesch , Frédéric Leroux , Francoise Colobert-Leuenberger
Advanced Synthesis and Catalysis, 2013, 355 (11-12), pp.2139-2144. ⟨10.1002/adsc.201300446⟩
Journal articles hal-02304106v1

Aryne-mediated fluorination: Synthesis of fluorinated biaryls via a sequential desilylation-halide elimination-fluoride addition process

Vincent Diemer , Juan Garcia , Frédéric Leroux , Francoise Colobert-Leuenberger
Journal of Fluorine Chemistry, 2012, 134, pp.146-155. ⟨10.1016/j.jfluchem.2011.02.017⟩
Journal articles hal-02306231v1

Triazolopyridines. Part 28. The ring-chain isomerization strategy: triazolopyridine- and triazoloquinoline-pyridine based fluorescence ligands

Rafael Ballesteros-Garrido , Estefania Delgado-Pinar , Belen Abarca , Rafael Ballesteros , Frédéric Leroux et al.
Tetrahedron, 2012, 68 (19), pp.3701-3707. ⟨10.1016/j.tet.2012.03.029⟩
Journal articles hal-02306237v1

Transition-Metal-Free Atropo-Selective Synthesis of Biaryl Compounds Based on Arynes

Frédéric Leroux , Anaïs Brehier , Laurence Bonnafoux , Armen Panossian , Francoise Colobert-Leuenberger et al.
Chemistry - A European Journal, 2012, 18 (45), pp.14232-14236. ⟨10.1002/chem.201202739⟩
Journal articles hal-02306232v1

Construction of the biaryl-part of vancomycin aglycon via atropo-diastereoselective Suzuki-Miyaura coupling

Timo Leermann , Pierre-Emmanuel Broutin , Frédéric Leroux , Francoise Colobert-Leuenberger
Organic & Biomolecular Chemistry, 2012, 10 (20), pp.4095-4102. ⟨10.1039/c2ob25373a⟩
Journal articles hal-02306241v1

Stereoselective Synthesis of P-Chirogenic Dibenzophosphole-Boranes via Aryne Intermediates

Vincent Diemer , Anaïs Brehier , Jerome Bayardon , Sylvain Juge , Frédéric Leroux et al.
Journal of Organic Chemistry, 2012, 77 (14), pp.6117-6127. ⟨10.1021/jo3009098⟩
Journal articles hal-02306244v1

Stereoselective Synthesis of o -Bromo (or Iodo)aryl P-Chirogenic Phosphines Based on Aryne Chemistry

Frédéric R. Leroux , Jérôme Bayardon , Hugo Laureano , Vincent Diemer , Mathieu Dutartre et al.
Journal of Organic Chemistry, 2012, 77 (13), pp.5759-5769. ⟨10.1021/jo300910w⟩
Journal articles hal-03004233v1

Regioselectivity in the Aryne Cross-Coupling of Aryllithiums with Functionalized 1,2-Dibromobenzenes

Vincent Diemer , Manon Begaud , Frédéric Leroux , Francoise Colobert-Leuenberger
European Journal of Organic Chemistry, 2011, 2, pp.341-354. ⟨10.1002/ejoc.201001283⟩
Journal articles hal-02306235v1

Bromine-lithium exchange: An efficient tool in the modular construction of biaryl ligands

Laurence Bonnafoux , Frédéric Leroux , Francoise Colobert-Leuenberger
Beilstein Journal of Organic Chemistry, 2011, 7, pp.1278-1287. ⟨10.3762/bjoc.7.148⟩
Journal articles hal-02307798v1

Highly Efficient One-Pot Access to Functionalized Arylboronic Acids via Noncryogenic Bromine/Magnesium Exchanges

Timo Leermann , Frédéric Leroux , Francoise Colobert-Leuenberger
Organic Letters, 2011, 13 (17), pp.4479-4481. ⟨10.1021/ol2016252⟩
Journal articles hal-02305220v1

Efficient and Complementary Methods Offering Access to Synthetically Valuable 1,2-Dibromobenzenes

Vincent Diemer , Frédéric Leroux , Francoise Colobert-Leuenberger
European Journal of Organic Chemistry, 2011, 2, pp.327-340. ⟨10.1002/ejoc.201001217⟩
Journal articles hal-02306234v1

Polar Organometallic Chemistry

Frédéric Leroux
Current Organic Chemistry, 2011, 15 (13)
Journal articles hal-02305223v1

Catalytic Palladium Phosphination: Modular Synthesis of C1-Symmetric Biaryl-Based Diphosphines

Laurence Bonnafoux , Rafael Gramage-Doria , Francoise Colobert , Frederic R. Leroux
Chemistry - A European Journal, 2011, 17 (39), pp.11008-11016. ⟨10.1002/chem.201101529⟩
Journal articles hal-01472931v1

Through-Space J(P,P) and J(P,F) Spin-Spin Coupling in C-1-Symmetric Biaryl Diphosphanes

Laurence Bonnafoux , Ludger Ernst , Frédéric Leroux , Francoise Colobert-Leuenberger
European Journal of Inorganic Chemistry, 2011, 22, pp.3387-3397. ⟨10.1002/ejic.201100428⟩
Journal articles hal-02306233v1

[1,2,3]Triazolo[1,5-a]pyridyl phosphines reflecting the influence of phosphorus lone pair orientation on spectroscopic properties

Rafael Ballesteros-Garrido , Laurence Bonnafoux , Fernando Blanco , Rafael Ballesteros , Frédéric Leroux et al.
Dalton Transactions, 2011, 40 (6), pp.1387-1395. ⟨10.1039/C0DT01183E⟩
Journal articles hal-02306239v1

A General Approach to (Trifluoromethoxy)pyridines: First X-ray Structure Determinations and Quantum Chemistry Studies

Baptiste Manteau , Pierre Genix , Lydia Brelot , Jean-Pierre Vors , Sergiy Pazenok et al.
European Journal of Organic Chemistry, 2010, 2010 (31), pp.6043-6066. ⟨10.1002/ejoc.201000958⟩
Journal articles hal-03370334v1

2,2′,6-Tribromobiphenyl via Transition-Metal-Free ARYNE Coupling: A Valuable Tool in the Synthesis of Biphenyls

Frédéric R. Leroux , Laurence Bonnafoux , Françoise Colobert
SYNLETT, 2010, 2010 (19), pp.2953-2955. ⟨10.1055/s-0030-1259025⟩
Journal articles hal-03366549v1

Efficient synthesis of quaternary and P-stereogenic phosphonium triflates

Emmanuelle Remond , Arnaud Tessier , Frédéric Leroux , Jérome Bayardon , Sylvain Jugé et al.
Organic Letters, 2010, 12 (7), pp.1568-1571. ⟨10.1021/ol100304c⟩
Journal articles hal-00474388v1

Modern Fluorine-Containing Agrochemicals

Sergii Pazenok , Frédéric Leroux
Frontiers of Organofluorine Chemistry, WORLD SCIENTIFIC (EUROPE), pp.695-732, 2020, ⟨10.1142/9781786347336_0016⟩
Book sections hal-03940952v1

Rapport de Conjoncture du CoNRS 2014 (INC / Section 12)

Chantal Andraud , Philippe Belmont , J.M. Campagne , Gaëlle Chouraqui , Emmanuel Gras et al.
CNRS Editions, Paris,. Rapport de Conjoncture du CoNRS 2014, CNRS Editions, Paris,, pp.255-274, 2014, 978-2-271-08746-1
Book sections hal-02338362v1

Modern Fluorine‐Containing Agrochemicals

Sergii Pazenok , David Bernier , Morgan Donnard , Gilles Hanquet , Armen Panossian et al.
PATAI'S Chemistry of Functional Groups, Wiley, 2009, 9780470682531. ⟨10.1002/9780470682531.pat1013⟩
Book sections hal-03920395v1