Geoffrey Guittard

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Targeting BTN2A1 enhances Vγ9Vδ2 T-cell effector functions and triggers tumor cell pyroptosis

Anne-Charlotte Le Floch , Caroline Imbert , Nicolas Boucherit , Laurent Gorvel , Stéphane Fattori et al.

Cancer Immunology Research, In press, 12 (12), pp.1677-1690. ⟨10.1158/2326-6066.CIR-23-0868⟩

Article dans une revue hal-04735873v1
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Enhancing natural killer cells proliferation and cytotoxicity using imidazole-based lipid nanoparticles encapsulating interleukin-2 mRNA

Christophe Delehedde , Ivan Ciganek , Pierre Louis Bernard , Nabila Laroui , Cathy Costa da Silva et al.

Molecular Therapy - Nucleic Acids, 2024, 35 (3), pp.102263. ⟨10.1016/j.omtn.2024.102263⟩

Article dans une revue hal-04772634v1
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DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing

Vladimir Laletin , Pierre-Louis Bernard , Camille Montersino , Yuji Yamanashi , Daniel Olive et al.

Scientific Reports, 2024, 14 (1), pp.15053. ⟨10.1038/s41598-024-66075-0⟩

Article dans une revue hal-04772643v1

DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing

Vladimir Laletin , Pierre-Louis Bernard , Camille Montersino , Yuji Y. Yamamoto , Daniel Olive et al.

Scientific Reports, 2024, 14 (1), pp.15053. ⟨10.1038/s41598-024-66075-0⟩

Article dans une revue hal-04654761v1
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Anti-HVEM mAb therapy improves antitumoral immunity both in vitro and in vivo, in a novel transgenic mouse model expressing human HVEM and BTLA molecules challenged with HVEM expressing tumors

Clémence Demerlé , Laurent Gorvel , Marielle Mello , Sonia Pastor , Clara Degos et al.

Journal for Immunotherapy of Cancer, 2023, 11 (5), pp.e006348. ⟨10.1136/jitc-2022-006348⟩

Article dans une revue hal-04114937v1

Production of CRISPRi-engineered primary human mammary epithelial cells with baboon envelope pseudotyped lentiviral vectors

Sonia Pastor , Julien Wicinski , Emmanuelle Charafe-Jauffret , Els Verhoeyen , Geoffrey Guittard et al.

STAR Protocols, 2023, 4 (1), pp.102055. ⟨10.1016/j.xpro.2023.102055⟩

Article dans une revue hal-04735885v1
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Negative intracellular regulators of T-cell receptor (TCR) signaling as potential antitumor immunotherapy targets

Vladimir Laletin , Pierre-Louis Bernard , Cathy Costa da Silva , Geoffrey Guittard , Jacques Nunes

Journal for Immunotherapy of Cancer, 2023, 11 (5), pp.e005845. ⟨10.1136/jitc-2022-005845⟩

Article dans une revue (article de synthèse) hal-04114285v1
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TET2 regulates immune tolerance in chronically activated mast cells

Riccardo Rigo , Rabie Chelbi , Julie Agopian , Sebastien Letard , Aurélien Griffon et al.

JCI Insight, 2022, 7 (7), pp.e004244. ⟨10.1172/jci.insight.154191⟩

Article dans une revue hal-04772652v1
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XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation

Laia Richart , Mary-Loup Picod-Chedotel , Michel Wassef , Manon Macario , Setareh Aflaki et al.

Cell, 2022, 185 (12), pp.2164-2183.e25. ⟨10.1016/j.cell.2022.04.034⟩

Article dans une revue hal-03951681v1
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CISH Expression Is Associated with Metastasis-Free Interval in Triple-Negative Breast Cancer and Refines the Prognostic Value of PDL1 Expression

Laurys Boudin , Alexandre de Nonneville , Pascal Finetti , Geoffrey Guittard , Jacques Nunes et al.

Cancers, 2022, 14 (14), pp.3356. ⟨10.3390/cancers14143356⟩

Article dans une revue hal-03765362v1
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Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity

Pierre-Louis Bernard , Rebecca Delconte , Sonia Pastor , Vladimir Laletin , Cathy Costa da Silva et al.

Journal for Immunotherapy of Cancer, 2022, 10 (5), pp.e004244. ⟨10.1136/jitc-2021-004244⟩

Article dans une revue hal-03773961v1
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CISH Expression Is Associated with Metastasis-Free Interval in Triple-Negative Breast Cancer and Refines the Prognostic Value of PDL1 Expression

Laurys Boudin , Alexandre de Nonneville , Pascal Finetti , Geoffrey Guittard , Jacques Nunes et al.

Cancers, 2022, 14 (14), pp.3356. ⟨10.3390/cancers14143356⟩

Article dans une revue hal-04772648v1

NK Cell Priming From Endogenous Homeostatic Signals Is Modulated by CIS

Rebecca Delconte , Geoffrey Guittard , Wilford Goh , Soroor Hediyeh-Zadeh , Robert Hennessy et al.

Frontiers in Immunology, 2020, 11, ⟨10.3389/fimmu.2020.00075⟩

Article dans une revue hal-04772658v1
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NK Cell Priming From Endogenous Homeostatic Signals Is Modulated by CIS

Rebecca B. Delconte , Geoffrey Guittard , Wilford Goh , Soroor Hediyeh-Zadeh , Robert J. Hennessy et al.

Frontiers in Immunology, 2020, 11, pp.75. ⟨10.3389/fimmu.2020.00075⟩

Article dans une revue hal-02533541v1
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Une piste en immunothérapie du cancer

Pierre-Louis Bernard , Vladimir Laletin , Sonia Pastor , Jacques Nunès , Geoffrey Guittard

Médecine/Sciences, 2020, 36, pp.50-55. ⟨10.1051/medsci/2020195⟩

Article dans une revue inserm-03152135v1
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Vitamin D Controls Tumor Growth and CD8+ T Cell Infiltration in Breast Cancer

Esma Karkeni , Stephanie Morin , Berna Bou Tayeh , Armelle Goubard , Emmanuelle Josselin et al.

Frontiers in Immunology, 2019, 10, pp.1307. ⟨10.3389/fimmu.2019.01307⟩

Article dans une revue hal-02528933v1

Vitamin D Controls Tumor Growth and CD8+ T Cell Infiltration in Breast Cancer

Esma Karkeni , Stéphanie Morin , Berna Bou Tayeh , Armelle Goubard , Emmanuelle Josselin et al.

Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.01307⟩

Article dans une revue hal-04772659v1
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TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling

Bochra Zidi , Christelle Vincent-Fabert , Laurent Pouyet , Marion Seillier , Amelle Vandevelde et al.

Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (1), pp.211-216. ⟨10.1073/pnas.1809980116⟩

Article dans une revue hal-02145737v1

A Prime-Pull-Amplify Vaccination Strategy To Maximize Induction of Circulating and Genital-Resident Intraepithelial CD8+ Memory T Cells

Nicolas Çuburu , Rina Kim , Geoffrey Guittard , Cynthia Thompson , Patricia Day et al.

Journal of Immunology, 2019, 202 (4), pp.1250-1264. ⟨10.4049/jimmunol.1800219⟩

Article dans une revue hal-04772662v1
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Evolutionary and expression analyses reveal a pattern of ancient duplications and functional specializations in the diversification of the Downstream of Kinase (DOK) genes

Geoffrey Guittard , Pierre Pontarotti , Samuel Granjeaud , Magda Rodrigues , Laurent Abi-Rached et al.

Developmental and Comparative Immunology, 2018, 84, pp.193-198. ⟨10.1016/j.dci.2018.02.011⟩

Article dans une revue hal-04772664v1

TP53INP1 deficiency maintains murine B lymphopoiesis in aged bone marrow through redox-controlled IL-7R/STAT5 signaling

Bochra Zidi , Christelle Vincent-Fabert , Laurent Pouyet , Marion Seillier , Amelle Vandevelde et al.

Proceedings of the National Academy of Sciences of the United States of America, 2018, 116 (1), pp.211-216. ⟨10.1073/pnas.1809980116⟩

Article dans une revue hal-04772663v1
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Evolutionary and expression analyses reveal a pattern of ancient duplications and functional specializations in the diversification of the Downstream of Kinase (DOK) genes

Geoffrey Guittard , Pierre Pontarotti , Samuel Granjeaud , Magda Rodrigues , Laurent Abi-Rached et al.

Developmental and Comparative Immunology, 2018, 84, pp.193-198. ⟨10.1016/j.dci.2018.02.011⟩

Article dans une revue inserm-02148721v1
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The Cish SH2 domain is essential for PLC-gamma 1 regulation in TCR stimulated CD8(+) T cells

Geoffrey Guittard , Ana Dios-Esponera , Douglas C. Palmer , Itoro Akpan , Valarie A. Barr et al.

Scientific Reports, 2018, 8 (5336), ⟨10.1038/s41598-018-23549-2⟩

Article dans une revue hal-02143617v1

The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8+ T cells

Geoffrey Guittard , Ana Dios-Esponera , Douglas Palmer , Itoro Akpan , Valarie Barr et al.

Scientific Reports, 2018, 8 (1), pp.5336. ⟨10.1038/s41598-018-23549-2⟩

Article dans une revue hal-04772666v1
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Unexpected Cartilage Phenotype in CD4-Cre-Conditional SOS-Deficient Mice

Geoffrey Guittard , Devorah Gallardo , Wenmei Li , Nicolas Melis , Julian Lui et al.

Frontiers in Immunology, 2017, 8, ⟨10.3389/fimmu.2017.00343⟩

Article dans une revue hal-04772669v1

Ionic immune suppression within the tumour microenvironment limits T cell effector function

Robert Eil , Suman Vodnala , David Clever , Christopher Klebanoff , Madhusudhanan Sukumar et al.

Nature, 2016, 537 (7621), pp.539-543. ⟨10.1038/nature19364⟩

Article dans une revue hal-04772670v1

Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance

Douglas Palmer , Geoffrey Guittard , Zulmarie Franco , Joseph Crompton , Robert Eil et al.

Journal of Experimental Medicine, 2015, 212 (12), pp.2095-2113. ⟨10.1084/jem.20150304⟩

Article dans une revue hal-04772671v1

Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules

A Rodriguez-Peña , J Gomez-Rodriguez , R Kortum , D Palmer , Z Yu et al.

Gene Therapy, 2015, 22 (10), pp.781-792. ⟨10.1038/gt.2015.48⟩

Article dans une revue hal-04772673v1

Absence of both Sos‐1 and Sos‐2 in peripheral CD4 + T cells leads to PI3K pathway activation and defects in migration

Geoffrey Guittard , Robert Kortum , Lakshmi Balagopalan , Nicolas Çuburu , Phan Nguyen et al.

European Journal of Immunology, 2015, 45 (8), pp.2389-2395. ⟨10.1002/eji.201445226⟩

Article dans une revue hal-04772674v1
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An Emerging Role for PI5P in T Cell Biology.

Jacques A. Nunès , Geoffrey Guittard

Frontiers in Immunology, 2013, 4, pp.80. ⟨10.3389/fimmu.2013.00080⟩

Article dans une revue inserm-00828688v1

An Emerging Role for PI5P in T Cell Biology

Jacques Nunès , Geoffrey Guittard

Frontiers in Immunology, 2013, 4, ⟨10.3389/fimmu.2013.00080⟩

Article dans une revue hal-04772676v1

B7-DC-Ig Enhances Vaccine Effect by a Novel Mechanism Dependent on PD-1 Expression Level on T Cell Subsets

Mikayel Mkrtichyan , Yana Najjar , Estella Raulfs , Linda Liu , Solomon Langerman et al.

Journal of Immunology, 2012, 189 (5), pp.2338-2347. ⟨10.4049/jimmunol.1103085⟩

Article dans une revue hal-04772677v1

Evidence for a positive role of PtdIns5P in T‐cell signal transduction pathways

Geoffrey Guittard , Eva Mortier , Hélène Tronchère , Guylène Firaguay , Audrey Gérard et al.

FEBS Letters, 2010, 584 (11), pp.2455-2460. ⟨10.1016/j.febslet.2010.04.051⟩

Article dans une revue hal-04772679v1
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Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways.

Geoffrey Guittard , Eva Mortier , Hélène Tronchère , Guylène Firaguay , Audrey Gérard et al.

FEBS Letters, 2010, 584 (11), pp.2455-60. ⟨10.1016/j.febslet.2010.04.051⟩

Article dans une revue inserm-00474713v1
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Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells.

Geoffrey Guittard , Audrey Gérard , Sophie Dupuis-Coronas , Hélène Tronchère , Eva Mortier et al.

Journal of Immunology, 2009, 182 (7), pp.3974-8. ⟨10.4049/jimmunol.0804172⟩

Article dans une revue inserm-00364224v1
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Dok-4 is a novel negative regulator of T cell activation.

Audrey Gérard , Marguerite Ghiotto , Camille Fos , Geoffrey Guittard , Daniel Compagno et al.

Journal of Immunology, 2009, 182 (12), pp.7681-9. ⟨10.4049/jimmunol.0802203⟩

Article dans une revue inserm-00374930v1

Dok-4 Is a Novel Negative Regulator of T Cell Activation

Audrey Gérard , Marguerite Ghiotto , Camille Fos , Geoffrey Guittard , Daniel Compagno et al.

Journal of Immunology, 2009, 182 (12), pp.7681-7689. ⟨10.4049/jimmunol.0802203⟩

Article dans une revue hal-04772680v1

Cutting Edge: Dok-1 and Dok-2 Adaptor Molecules Are Regulated by Phosphatidylinositol 5-Phosphate Production in T Cells

Geoffrey Guittard , Audrey Gérard , Sophie Dupuis-Coronas , Hélène Tronchère , Eva Mortier et al.

Journal of Immunology, 2009, 182 (7), pp.3974-3978. ⟨10.4049/jimmunol.0804172⟩

Article dans une revue hal-04772682v1