Georg Mellitzer

29
Documents

Publications

Publications

Evaluation of dual-function molecules containing both Zn-Ionophore and aggregation inhibition moieties for mutant p53 protein reactivation

Kalvin Kwan , Ashkan Saffari , Lauryn Grcic , Alfredo Acosta , Grace Leech et al.
Journal of Inorganic Biochemistry, 2026, 274, pp.113088. ⟨10.1016/j.jinorgbio.2025.113088⟩
Article dans une revue inserm-05314293 v1
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Inverse Correlation between Endoplasmic Reticulum Stress Intensity and Antitumor Immune Response with Ruthenium(II)-Based Photosensitizers for the Photodynamic Therapy of Head and Neck Squamous Cell Carcinoma

Chloé Thibaudeau , Cyril Bour , Matthieu Scarpi-Luttenauer , Pierre Mesdom , Johannes Karges et al.
Journal of Medicinal Chemistry, 2025, ⟨10.1021/acs.jmedchem.5c02147⟩
Article dans une revue hal-05374218 v1
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Protoporphyrin IX-Derived Ruthenium(II) Complexes for Photodynamic Therapy in Gastric Cancer Cells

Andrés Restrepo-Acevedo , María Isabel Murillo , Christophe Orvain , Chloé Thibaudeau , Sevda Recberlik et al.
Inorganic Chemistry, 2025, 64 (19), pp.9684-9702. ⟨10.1021/acs.inorgchem.5c00896⟩
Article dans une revue inserm-05210823 v1
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The unfolded protein response-glutathione metabolism axis: A novel target of a cycloruthenated complexes bypassing tumor resistance mechanisms

Gilles Riegel , Christophe Orvain , Sevda Recberlik , Marie-Elodie Spaety , Gernot Poschet et al.
Cancer Letters, 2024, 585, pp.216671. ⟨10.1016/j.canlet.2024.216671⟩
Article dans une revue hal-04721006 v1
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A novel ΔNp63-dependent immune mechanism improves prognosis of HPV-related head and neck cancer

Jana Mourtada , Christelle Lony , Anaïs Nicol , Justine de Azevedo , Cyril Bour et al.
Frontiers in Immunology, 2023, 14, pp.1264093. ⟨10.3389/fimmu.2023.1264093⟩
Article dans une revue hal-04440322 v1
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Histone Deacetylase Functions in Gastric Cancer: Therapeutic Target?

Amandine Badie , Christian Gaiddon , Georg Mellitzer
Cancers, 2022, 14 (21), pp.5472. ⟨10.3390/cancers14215472⟩
Article dans une revue inserm-05281008 v1
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The EXTREME Regimen Associating Cetuximab and Cisplatin Favors Head and Neck Cancer Cell Death and Immunogenicity with the Induction of an Anti-Cancer Immune Response

Justine de Azevedo , Jana Mourtada , Cyril Bour , Veronique Devignot , Philippe Schultz et al.
Cells, 2022, 11 (18), ⟨10.3390/cells11182866⟩
Article dans une revue hal-04889946 v1
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Morpho-functional analysis of patient-derived xenografts reveals differential impact of gastric cancer and chemotherapy on the tumor ecosystem, affecting immune check point, metabolism, and sarcopenia

A. Venkatasamy , E. Guerin , W. Reichardt , V. Devignot , M P Chenard et al.
Gastric Cancer, 2022, 26 (2), pp.220-233. ⟨10.1007/s10120-022-01359-w⟩
Article dans une revue hal-04295287 v1
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Isoforms of the p53 Family and Gastric Cancer: A Ménage à Trois for an Unfinished Affair

Anais Blanchet , Agathe Bourgmayer , Jean-Emmanuel Kurtz , Georg Mellitzer , Christian Gaiddon
Cancers, 2021, 13 (4), pp.916. ⟨10.3390/cancers13040916⟩
Article dans une revue hal-03451009 v1
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Ultrasound and Transcriptomics Identify a Differential Impact of Cisplatin and Histone Deacetylation on Tumor Structure and Microenvironment in a Patient-Derived In Vivo Model of Gastric Cancer

Aina Venkatasamy , Eric Guerin , Anais Blanchet , Christophe Orvain , Véronique Devignot et al.
Pharmaceutics, 2021, 13 (9), pp.1485. ⟨10.3390/pharmaceutics13091485⟩
Article dans une revue hal-03450657 v1

The atypical cadherin MUCDHL antagonizes colon cancer formation and inhibits oncogenic signaling through multiple mechanisms

Marine Beck , Mathilde Baranger , Ahlam Moufok-Sadoun , Emilie Bersuder , Isabelle Hinkel et al.
Oncogene, 2021, 40, pp.522-535. ⟨10.1038/s41388-020-01546-y⟩
Article dans une revue hal-03044463 v1

Bypassing the Resistance Mechanisms of the Tumor Ecosystem by Targeting the Endoplasmic Reticulum Stress Pathway Using Ruthenium- and Osmium-Based Organometallic Compounds: An Exciting Long-Term Collaboration with Dr. Michel Pfeffer

Christian Gaiddon , Isabelle Gross , Xiangjun Meng , Marjorie Sidhoum , Georg Mellitzer et al.
Molecules, 2021, 26 (17), pp.5386. ⟨10.3390/molecules26175386⟩
Article dans une revue hal-03450715 v1

Anticancer activity of ruthenium and osmium cyclometalated compounds: identification of ABCB1 and EGFR as resistance mechanisms

Cynthia Licona , Jean-Baptiste Delhorme , Gilles Riegel , Vania Vidimar , Ricardo Cerón-Camacho et al.
Inorganic Chemistry Frontiers, 2020, 7 (3), pp.678-688. ⟨10.1039/C9QI01148J⟩
Article dans une revue hal-03013615 v1
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A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53

Vania Vidimar , Cynthia Licona , Ricardo Cerón-Camacho , Eric Guérin , Pierre Coliat et al.
Cancer Letters, 2019, 440-441, pp.145-155. ⟨10.1016/j.canlet.2018.09.029⟩
Article dans une revue inserm-02363227 v1
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HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway

Marie-Elodie Spaety , Alexandre Gries , Amandine Badie , Aina Venkatasamy , Benoît Romain et al.
Cancers, 2019, 11 (11), pp.1747. ⟨10.3390/cancers11111747⟩
Article dans une revue inserm-02363213 v1
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Structural tuning of organoruthenium compounds allows oxidative switch to control ER stress pathways and bypass multidrug resistance

Mun Juinn Chow , Cynthia Licona , Giorgia Pastorin , Georg Mellitzer , Wee Han Ang et al.
Chemical Science, 2016, 7 (7), pp.4117-4124. ⟨10.1039/c6sc00268d⟩
Article dans une revue inserm-02365338 v1
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Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63

Yannick von Grabowiecki , Paula Abreu , Orphee Blanchard , Lavinia Palamiuc , Samir Benosman et al.
eLife, 2016, 5, pp.e10528. ⟨10.7554/eLife.10528⟩
Article dans une revue inserm-02365332 v1

Subcellular Localization and Transport Kinetics of Ruthenium Organometallic Anticancer Compounds in Living Cells: A Dose-Dependent Role for Amino Acid and Iron Transporters

M Klajner , Cynthia Licona , L Fetzer , Pascal Hébraud , Georg Mellitzer et al.
Inorganic Chemistry, 2014, 53 (10), pp.5150-5158. ⟨10.1021/ic500250e⟩
Article dans une revue hal-04684613 v1
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Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity

Neal Anthwal , Michelle Pelling , Suzanne Claxton , Georg Mellitzer , Caitlin Collin et al.
Disease Models & Mechanisms, 2013, ⟨10.1242/dmm.011916⟩
Article dans une revue hal-04006946 v1

Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity

Vania Vidimar , Xiangjun Meng , Marcelina Klajner , Cynthia Licona , Ludivine Fetzer et al.
Biochemical Pharmacology, 2012, 84 (11), pp.1428-1436. ⟨10.1016/j.bcp.2012.08.022⟩
Article dans une revue istex hal-04654755 v1
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Complex Regulation of p73 Isoforms after Alteration of Amyloid Precursor Polypeptide (APP) Function and DNA Damage in Neurons

S Benosman , X Meng , Y von Grabowiecki , L Palamiuc , L Hritcu et al.
Journal of Biological Chemistry, 2011, 286 (50), pp.43013-43025. ⟨10.1074/jbc.M111.261271⟩
Article dans une revue hal-05259710 v1

Enteroendocrine cells and lipid absorption

Georges Mellitzer , Gerard Gradwohl
Current Opinion in Lipidology, 2011, 22 (3), pp.171-175. ⟨10.1097/MOL.0b013e32834622a2⟩
Article dans une revue hal-04692450 v1
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Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

François Gerbe , Johan van Es , Leila Makrini , Bénédicte Brulin , Georg Mellitzer et al.
Journal of Cell Biology, 2011, 192 (5), pp.767-780. ⟨10.1083/jcb.201010127⟩
Article dans une revue hal-02459483 v1

Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development

Josselin Soyer , Lydie Flasse , Wolfgang Raffelsberger , Anthony Beucher , Christophe Orvain et al.
Development (Cambridge, England), 2010, 137 (2), pp.203-212. ⟨10.1242/dev.041673⟩
Article dans une revue hal-04088194 v1

GeneSpeed Beta Cell: an online genomics data repository and analysis resource tailored for the islet cell biologist

Nayeem Quayum , Alecksandr Kutchma , Suparna A. Sarkar , Kirstine Juhl , Gerard Gradwohl et al.
Experimental Diabetes Research, 2008, 2008, ⟨10.1155/2008/312060⟩
Article dans une revue hal-04118007 v1

Genetic determinants of pancreatic epsilon-cell development.

R Scott Heller , Marjorie Jenny , Patrick Collombat , Ahmed Mansouri , Catherine Tomasetto et al.
Developmental Biology, 2005, 286 (1), pp.217-24. ⟨10.1016/j.ydbio.2005.06.041⟩
Article dans une revue istex hal-00187550 v1
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STAT5 Involvement in the Differentiation Response of Primary Chicken Myeloid Progenitor Cells to Chicken Myelomonocytic Growth Factor

Irina Woldman , Georg Mellitzer , Matthias Kieslinger , Dieter Buchhart , Andreas Meinke et al.
Journal of immunotherapy : official journal of the Society for Biological Therapy, 1997, 159 (2), pp.877-886
Article dans une revue inserm-05281177 v1