Gildas BERTHO

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Publications

Characterization of POP mixture redistribution and identification of their molecular signature in xenografted fat mice

Théo Jamay , Philippe Noirez , Haidar Djemai , Layale Youssef , Justine Massias et al.

Environmental Pollution, 2025, 374, pp.126239. ⟨10.1016/j.envpol.2025.126239⟩

Article dans une revue hal-05079695v1
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Metabolic Heterogeneity in Diffuse Large B-Cell Lymphoma Cells Reveals an Innovative Antimetabolic Combination Strategy

Leonardo Lordello , Stéphanie Nuan-Aliman , Karoline Kielbassa-Elkadi , Aurélie Montagne , Konstantina Kotta et al.

Cancers, 2025, 17 (3), pp.394. ⟨10.3390/cancers17030394⟩

Article dans une revue (data paper) hal-05053122v1

Methylglyoxal-Induced Glycation of Plasma Albumin: From Biomarker Discovery to Clinical Use for Prediction of New-Onset Diabetes in Individuals with Prediabetes

Arsênio Rodrigues Oliveira , Chloé Chevalier , Matthieu Wargny , Victoria Pakulska , Cédric Caradeuc et al.

Clinical Chemistry, 2025, 71 (6), pp.688-699. ⟨10.1093/clinchem/hvaf035⟩

Article dans une revue hal-05387570v1
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Phytochemical Study of the Anthelminthic Potential of Guadeloupean Plant Biodiversity

Tressy Cabald , Carine Marie-Magdeleine , Lucien Philibert , Cédric Caradeuc , Gildas Bertho et al.

Pharmaceuticals, 2024, 17 (6), pp.774. ⟨10.3390/ph17060774⟩

Article dans une revue hal-04670316v1

The analysis of the skeletal muscle metabolism is crucial for designing optimal exercise paradigms in type 2 diabetes mellitus

Elias Abi Akar , Laure Weill , Mirella El Khoury , Cédric Caradeuc , Gildas Bertho et al.

Molecular Medicine, 2024, 30 (1), pp.80. ⟨10.1186/s10020-024-00850-7⟩

Article dans une revue hal-05316643v1

Revisiting the nature and pharmacodynamics of tacrolimus metabolites

Rudy Mevizou , Hassan Aouad , François-Ludovic Sauvage , Hélène Arnion , Emilie Pinault et al.

Pharmacological Research, 2024, 209, pp.107438. ⟨10.1016/j.phrs.2024.107438⟩

Article dans une revue hal-05291791v1
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One touch is all it takes: the supramolecular interaction between ubiquitin and lanthanide complexes revisited by paramagnetic NMR and molecular dynamics

Karen dos Santos , Alessio Bartocci , Natacha Gillet , Sandrine Denis-Quanquin , Amandine Roux et al.

Physical Chemistry Chemical Physics, 2024, 26 (20), pp.14573 - 14581. ⟨10.1039/d4cp00463a⟩

Article dans une revue hal-04609190v1
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NMR metabolomics study of chronic low‐dose exposure to a cocktail of persistent organic pollutants

Covadonga Lucas-Torres , Cédric Caradeuc , Laura Prieur , Haidar Djemai , Layale Youssef et al.

NMR in Biomedicine, 2023, 36 (11), pp.e5006. ⟨10.1002/nbm.5006⟩

Article dans une revue hal-04182525v1

Ultrahigh-Resolution NMR with Water Signal Suppression for a Deeper Understanding of the Action of Antimetabolic Drugs on Diffuse Large B-Cell Lymphoma

Gildas Bertho , Leonardo Lordello , Xi Chen , Covadonga Lucas-Torres , Imed Eddine Oumezziane et al.

Journal of Proteome Research, 2022, 21 (4), pp.1041-1051. ⟨10.1021/acs.jproteome.1c00914⟩

Article dans une revue hal-03648893v1
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Structural analysis of unstable norbixin isomers guided by pure shift nuclear magnetic resonance

Gildas Bertho , Imed Eddine Oumezziane , Cédric Caradeuc , Louis Guibout , Christine Balducci et al.

Magnetic Resonance in Chemistry, 2022, 60 (5), pp.504-514. ⟨10.1002/mrc.5252⟩

Article dans une revue hal-03648920v1
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Synthesis and characterization of novel conformers of ( E ) ‐ 2‐(3‐nitro‐ H ‐imidazo[1,2‐ a ]pyridin‐2‐ylthio)‐ N ′‐benzylideneacetohydrazide derivatives

Evrard Ablo , Souleymane Coulibaly , Siomenan Coulibali , Kouassi Signo , Patrick‐armand Achi et al.

Magnetic Resonance in Chemistry, 2022, ⟨10.1002/mrc.5308⟩

Article dans une revue hal-03812767v1
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The complex metabolism of poststerone in male rats

Christine Balducci , Laurence Dinan , Louis Guibout , Anne-Sophie Foucault , Christel Carbonne et al.

Journal of Steroid Biochemistry and Molecular Biology, 2021, 212, pp.105897. ⟨10.1016/j.jsbmb.2021.105897⟩

Article dans une revue hal-03684677v1

On the Supra‐LUMO Interaction: Case Study of a Sudden Change of Electronic Structure as a Functional Emergence

Alexis Gosset , Štěpánka Nováková Lachmanová , Sawsen Cherraben , Gildas Bertho , Jérémy Forté et al.

Chemistry - A European Journal, 2021, 27 (71), pp.17889-17899. ⟨10.1002/chem.202103136⟩

Article dans une revue hal-03684619v1
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Distinction between 2′- and 3′-Phosphate Isomers of a Fluorescent NADPH Analogue Led to Strong Inhibition of Cancer Cells Migration

Raoul Manuel , Michelle de Souza Lima , Sébastien Dilly , Sylvain Daunay , Patricia Abbe et al.

Antioxidants , 2021, 10 (5), pp.723. ⟨10.3390/antiox10050723⟩

Article dans une revue hal-03248720v1
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Distinction between 2′- and 3′-Phosphate Isomers of a Fluorescent NADPH Analogue Led to Strong Inhibition of Cancer Cells Migration

Raoul Manuel , Michelle de Souza Lima , Sébastien Dilly , Sylvain Daunay , Patricia Abbe et al.

Antioxidants , 2021, 10, ⟨10.3390/antiox10050723⟩

Article dans une revue hal-03990867v1
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Loss of prion protein control of glucose metabolism promotes neurodegeneration in model of prion diseases

Hélène Arnould , Vincent Baudouin , Anne Baudry , Luiz Ribeiro , Hector Ardila-Osorio et al.

PLoS Pathogens, 2021, 17 (10), pp.e1009991. ⟨10.1371/journal.ppat.1009991⟩

Article dans une revue hal-03413478v1
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Adenomyosis is associated with specific proton nuclear magnetic resonance (1H-NMR) serum metabolic profiles

Mathilde Bourdon , Pietro Santulli , Fatiha Kateb , Khaled Pocate-Cheriet , Frederic Batteux et al.

Fertility and Sterility, 2021, 116 (1), pp.243-254. ⟨10.1016/j.fertnstert.2021.02.031⟩

Article dans une revue hal-03684698v1
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The follicular fluid metabolome differs according to the endometriosis phenotype

Khaled Pocate-Cheriet , Pietro Santulli , Fatiha Kateb , Mathilde Bourdon , Chloé Maignien et al.

Reproductive BioMedicine Online, 2020, 41, pp.1023 - 1037. ⟨10.1016/j.rbmo.2020.09.002⟩

Article dans une revue hal-03493619v1
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Endometriosis phenotypes are associated with specific serum metabolic profiles determined by proton-nuclear magnetic resonance

Chloé Maignien , Pietro Santulli , Fatiha Kateb , Cédric Caradeuc , Louis Marcellin et al.

Reproductive BioMedicine Online, 2020, 41, pp.640 - 652. ⟨10.1016/j.rbmo.2020.06.019⟩

Article dans une revue hal-03492022v1

Urinary metabolic profiling of asymptomatic acute intermittent porphyria using a rule-mining-based algorithm

Margaux Luck , Caroline Schmitt , Neila Talbi , Laurent Gouya , Cédric Caradeuc et al.

Metabolomics, 2018, 14 (1), pp.10. ⟨10.1007/s11306-017-1305-9⟩

Article dans une revue hal-03684742v1

Real-Time and Non-invasive Monitoring of the Activation of the IRE1α-XBP1 Pathway in Individuals with Hemodynamic Impairment

Baptiste Fohlen , Quentin Tavernier , Thi-Mum Huynh , Cédric Caradeuc , Delphine Le Corre et al.

EBioMedicine, 2018, 27, pp.284-292. ⟨10.1016/j.ebiom.2017.12.023⟩

Article dans une revue hal-03684748v1
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Specific Physical Exercise Improves Energetic Metabolism in the Skeletal Muscle of Amyotrophic-Lateral- Sclerosis Mice

Céline Desseille , Séverine Deforges , Olivier Biondi , Léo Houdebine , Domenico D’amico et al.

Frontiers in Molecular Neuroscience, 2017, 10, ⟨10.3389/fnmol.2017.00332⟩

Article dans une revue hal-03684756v1

Insights into the interaction of high potency inhibitor IRC-083864 with phosphatase CDC25

Manal Sarkis , Maria Miteva , Maria Chiara Dasso Lang , Maryse Jaouen , Marie-Agnès Sari et al.

Proteins: Structure, Function, and Bioinformatics, 2017, 85 (4), pp.593-601. ⟨10.1002/prot.25236⟩

Article dans une revue hal-03684762v1

Insights into the interaction of high potency inhibitor IRC-083864 with phosphatase CDC25

Manal Sarkis , Maria Miteva , Maria Chiara Dasso Lang , Maryse Jaouen , Marie-Agnès Sari et al.

Proteins: Structure, Function, and Bioinformatics, 2017, 85 (4), pp.593-601. ⟨10.1002/prot.25236⟩

Article dans une revue hal-03689998v1

Model of the Interaction between the NF-κB Inhibitory Protein p100 and the E3 Ubiquitin Ligase β-TrCP based on NMR and Docking Experiments

Maxime Melikian , Baptiste Eluard , Gildas Bertho , Véronique Baud , Nathalie Evrard-Todeschi

Journal of Chemical Information and Modeling, 2017, 57 (2), pp.223-233. ⟨10.1021/acs.jcim.5b00409⟩

Article dans une revue hal-03684765v1

Rule-Mining for the Early Prediction of Chronic Kidney Disease Based on Metabolomics and Multi-Source Data

Margaux Luck , Gildas Bertho , Mathilde Bateson , Alexandre Karras , Anastasia Yartseva et al.

PLoS ONE, 2016, 11 (11), pp.e0166905. ⟨10.1371/journal.pone.0166905⟩

Article dans une revue hal-03684770v1

Interaction of a small molecule Natura-α and STAT3-SH2 domain to block Y705 phosphorylation and inhibit lupus nephritis

J.W. Chiao , Maxime Melikian , Liying Han , Chengsen Xue , Allen Tsao et al.

Biochemical Pharmacology, 2016, 99, pp.123-131. ⟨10.1016/j.bcp.2015.11.018⟩

Article dans une revue hal-03684776v1

Expression in yeast, new substrates, and construction of a first 3D model of human orphan cytochrome P450 2U1: Interpretation of substrate hydroxylation regioselectivity from docking studies.

Lionel Ducassou , Gabriella Jonasson , Laura Dhers , Nicolas Pietrancosta , Booma Ramassamy et al.

BBA - Biochimica et Biophysica Acta, 2015, 1850 (7), pp.1426-37. ⟨10.1016/j.bbagen.2015.03.014⟩

Article dans une revue hal-01449701v1

The urinary metabolome of chronic kidney disease

Nicolas Pallet , Eric Thervet , Philippe Beaune , Alexandre Karras , Gildas Bertho

Kidney International, 2014, 85 (5), pp.1239-1240. ⟨10.1038/ki.2014.34⟩

Article dans une revue hal-03684819v1
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Novel RANK Antagonists for the Treatment of Bone-Resorptive Disease: Theoretical Predictions and Experimental Validation

Stéphane Téletchéa , Verena Stresing , Soizic Hervouet , Marc Baud'Huin , Marie-Françoise Heymann et al.

Journal of Bone and Mineral Research, 2014, 29 (6), pp.1466 - 1477. ⟨10.1002/jbmr.2170⟩

Article dans une revue inserm-01644748v1

Urinary Metabolic Fingerprint of Acute Intermittent Porphyria Analyzed by 1 H NMR Spectroscopy

Mickael Carichon , Nicolas Pallet , Caroline Schmitt , Thibaud Lefebvre , Laurent Gouya et al.

Analytical Chemistry, 2014, 86 (4), pp.2166-2174. ⟨10.1021/ac403837r⟩

Article dans une revue hal-03684829v1

A new derivative detected in accelerated ageing of artesunate-amodiaquine fixed dose combination tablets

Cedric Charrier , Gildas Bertho , Olivier Petigny , Philippe Moneton , Robert Azerad

Journal of Pharmaceutical and Biomedical Analysis, 2013, 81-82, pp.20-26. ⟨10.1016/j.jpba.2013.03.009⟩

Article dans une revue istex hal-03684836v1

Thiolactone Sulfoxides as New Reactive Metabolites Acting as Bis-Electrophiles: Implication in Clopidogrel and Prasugrel Bioactivation

Patrick Dansette , Dan Levent , Assia Hessani , Gildas Bertho , Daniel Mansuy

Chemical Research in Toxicology, 2013, 26 (5), pp.794-802. ⟨10.1021/tx400083b⟩

Article dans une revue hal-03684856v1

Toward Stable Electron Paramagnetic Resonance Oximetry Probes: Synthesis, Characterization, and Metabolic Evaluation of New Ester Derivatives of a Tris-( para -carboxyltetrathiaaryl)methyl (TAM) Radical

Christophe Decroos , Véronique Balland , Jean-Luc Boucher , Gildas Bertho , Yun Xu-Li et al.

Chemical Research in Toxicology, 2013, 26 (10), pp.1561-1569. ⟨10.1021/tx400250a⟩

Article dans une revue hal-03684842v1

Tryptophan Depletion and the Kinase GCN2 Mediate IFN-γ–Induced Autophagy

Sophie Fougeray , Iadh Mami , Gildas Bertho , Philippe Beaune , Eric Thervet et al.

Journal of Immunology, 2012, 189 (6), pp.2954-2964. ⟨10.4049/jimmunol.1201214⟩

Article dans une revue hal-03684891v1

Naphthalene-dioxygenase catalysed cis-dihydroxylation of bicyclic azaarenes

Claude Chopard , Gildas Bertho , Thierry Prangé

RSC Advances, 2012, 2 (2), pp.605-615. ⟨10.1039/C1RA00706H⟩

Article dans une revue hal-03684941v1

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis

Patricia Rada , Ana Rojo , Nathalie Evrard-Todeschi , Nadia Innamorato , Axelle Cotte et al.

Molecular and Cellular Biology, 2012, 32 (17), pp.3486-3499. ⟨10.1128/MCB.00180-12⟩

Article dans une revue hal-03684929v1

Contact-based ligand-clustering approach for the identification of active compounds in virtual screening

Gildas Bertho , Alexey Mantsyzov , Guillaume Bouvier , Nathalie Evrard-Todeschi

Advances and applications in bioinformatics and chemistry, 2012, pp.61. ⟨10.2147/AABC.S30881⟩

Article dans une revue hal-03684866v1

Metabolic Activation of Prasugrel: Nature of the Two Competitive Pathways Resulting in the Opening of Its Thiophene Ring

Patrick Dansette , Julien Rosi , Justine Debernardi , Gildas Bertho , Daniel Mansuy

Chemical Research in Toxicology, 2012, 25 (5), pp.1058-1065. ⟨10.1021/tx3000279⟩

Article dans une revue hal-03684932v1

Cytochromes P450 Catalyze Both Steps of the Major Pathway of Clopidogrel Bioactivation, whereas Paraoxonase Catalyzes the Formation of a Minor Thiol Metabolite Isomer

Patrick Dansette , Julien Rosi , Gildas Bertho , Daniel Mansuy

Chemical Research in Toxicology, 2012, 25 (2), pp.348-356. ⟨10.1021/tx2004085⟩

Article dans une revue hal-03684944v1

Paraoxonase-1 and clopidogrel efficacy

Patrick Dansette , Julien Rosi , Gildas Bertho , Daniel Mansuy

Nature Medicine, 2011, 17 (9), pp.1040-1041. ⟨10.1038/nm.2436⟩

Article dans une revue hal-03684957v1

Automatic clustering of docking poses in virtual screening process using self-organizing map

Guillaume Bouvier , Nathalie Evrard-Todeschi , Jean-Pierre Girault , Gildas Bertho

Bioinformatics, 2010, 26 (1), pp.53-60. ⟨10.1093/bioinformatics/btp623⟩

Article dans une revue hal-03684971v1

Formation and Fate of a Sulfenic Acid Intermediate in the Metabolic Activation of the Antithrombotic Prodrug Prasugrel

Patrick Dansette , Stéphanie Thébault , Gildas Bertho , Daniel Mansuy

Chemical Research in Toxicology, 2010, 23 (7), pp.1268-1274. ⟨10.1021/tx1001332⟩

Article dans une revue hal-03684983v1

Oxidative and Reductive Metabolism of Tris( p -carboxyltetrathiaaryl)methyl Radicals by Liver Microsomes

Christophe Decroos , Yun Li , Gildas Bertho , Yves Frapart , Daniel Mansuy et al.

Chemical Research in Toxicology, 2009, 22 (7), pp.1342-1350. ⟨10.1021/tx9001379⟩

Article dans une revue hal-03684990v1

Synthetic studies towards diazepanone scaffolds

Christophe Decroos , Yun Li , Gildas Bertho , Yves Frapart , Daniel Mansuy et al.

Tetrahedron: Asymmetry, 2009, 20 (20), pp.2320-2330. ⟨10.1016/j.tetasy.2009.09.022⟩

Article dans une revue istex hal-03685013v1

Metabolic Oxidative Cleavage of Thioesters: Evidence for the Formation of Sulfenic Acid Intermediates in the Bioactivation of the Antithrombotic Prodrugs Ticlopidine and Clopidogrel

Patrick Dansette , Julie Libraire , Gildas Bertho , Daniel Mansuy

Chemical Research in Toxicology, 2009, 22 (2), pp.369-373. ⟨10.1021/tx8004828⟩

Article dans une revue hal-03684993v1

Oxidation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes: evidence for their oxidative decarboxylation and molecular origin of their specific ability to react with O2˙−

Christophe Decroos , Yun Li , Gildas Bertho , Yves Frapart , Daniel Mansuy et al.

Chemical Communications, 2009, 11, pp.1416. ⟨10.1039/b819259f⟩

Article dans une revue istex hal-02102841v1

Transfer-NMR and Docking Studies Identify the Binding of the Peptide Derived from Activating Transcription Factor 4 to Protein Ubiquitin Ligase β-TrCP. Competition STD-NMR with β-Catenin

Julien Pons , Nathalie Evrard-Todeschi , Gildas Bertho , Josyane Gharbi-Benarous , Valérie Tanchou et al.

Biochemistry, 2008, 47 (1), pp.14-29. ⟨10.1021/bi7014212⟩

Article dans une revue istex hal-03685028v1

The key-role of tyrosine 155 in the mechanism of prion transconformation as highlighted by a study of sheep mutant peptides

Gildas Bertho , Guillaume Bouvier , Gaston Hui Bon Hoa , Jean-Pierre Girault

Peptides, 2008, 29 (7), pp.1073-1084. ⟨10.1016/j.peptides.2008.03.014⟩

Article dans une revue hal-03685032v1

Diastereoselective Additions to (3S)-3-Aminodehydrocaprolactams: Development of a Versatile Synthesis of New Substituted CyclicL-Lysines

Camille Levraud , Sandrine Calvet-Vitale , Gildas Bertho , Hamid Dhimane

European Journal of Organic Chemistry, 2008, 2008 (11), pp.1901-1909. ⟨10.1002/ejoc.200701004⟩

Article dans une revue istex hal-03685043v1

Structure of the Complex between Phosphorylated Substrates and the SCF β-TrCP Ubiquitin Ligase Receptor: A Combined NMR, Molecular Modeling, and Docking Approach

Nathalie Evrard-Todeschi , Julien Pons , Josyane Gharbi-Benarous , Gildas Bertho , Richard Benarous et al.

Journal of Chemical Information and Modeling, 2008, 48 (12), pp.2350-2361. ⟨10.1021/ci800248u⟩

Article dans une revue hal-03685021v1

Efficient synthesis of polyfunctionalised enantiopure diazepanone scaffolds

Olivier Monasson , Maryon Ginisty , Gildas Bertho , Christine Gravier-Pelletier , Yves Le Merrer

Tetrahedron Letters, 2007, 48 (46), pp.8149-8152. ⟨10.1016/j.tetlet.2007.09.098⟩

Article dans une revue istex hal-03685046v1

Allosteric tuning of the intra-cavity binding properties of a calix[6]arene through external binding to a Zn(II) center coordinated to amino arms

Ulrich Darbost , Olivier Sénèque , Yun Li , Gildas Bertho , Jerome Marrot et al.

Chemistry - A European Journal, 2006, 13, pp.2078-2088. ⟨10.1002/chem.200601040⟩

Article dans une revue istex hal-00391396v1

STD and TRNOESY NMR studies for the epitope mapping of the phosphorylation motif of the oncogenic protein beta-catenin recognized by a selective monoclonal antibody.

Simon Megy , Gildas Bertho , Josyane Gharbi-Benarous , Françoise Baleux , Richard Benarous et al.

FEBS Letters, 2006, 580 (22), pp.5411-22. ⟨10.1016/j.febslet.2006.08.084⟩

Article dans une revue istex pasteur-00166653v1

First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives

Patrick M. Dansette , Gildas Bertho , Daniel Mansuy

Biochemical and Biophysical Research Communications, 2005, 338, pp.450-455. ⟨10.1016/j.bbrc.2005.08.091⟩

Article dans une revue istex hal-00068627v1

Solution structure of a peptide derived from the oncogenic protein beta-Catenin in its phosphorylated and nonphosphorylated states.

Simon Megy , Gildas Bertho , Josyane Gharbi-Benarous , Françoise Baleux , Richard Benarous et al.

Peptides / Peptides (Fayetteville), 2005, 26 (2), pp.227-41. ⟨10.1016/j.peptides.2004.09.021⟩

Article dans une revue istex pasteur-00166821v1

Possible role of region 152-156 in structural duality of a peptide fragment from sheep prion protein

Simon Megy , Gildas Bertho , Serguey A. Kozin , Marie Pascale M. P. Debey , Gaston Hui Bon Hoa et al.

Protein Science, 2004, 13 (12), pp.3151-3160. ⟨10.1110/ps.04745004⟩

Article dans une revue hal-02677622v1

Metabolic Profiling of 1H NMR Spectra in Chronic Kidney Disease with Local Predictive Modeling

M.M. Luck , A. Yartseva , Gildas Bertho , E. Thervet , Philippe Beaune et al.

2015 IEEE 14th International Conference on Machine Learning and Applications (ICMLA), Dec 2015, Miami, France. pp.176-181, ⟨10.1109/ICMLA.2015.155⟩

Communication dans un congrès hal-03684787v1
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Characterization of diffuse large B-cell lymphoma subgroups by metabolomic analyses

Nathalie Lacrampe , Emeline Chu-Van , Sylvain Dechaumet , Aurélie Montagne , Cédric Caradeuc et al.

16e Journées Scientifiques du Réseau Francophone de Métabolomique et de Fluxomique, Jun 2024, Saint-Malo, France

Poster de conférence hal-05149277v1
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A NEW THIOPHENE METABOLITE: NADPH, O 2 AND THIOL DEPENDENT FORMATION OF A THIOPHENE HYDRATE FROM (S)-MTPPA BY CYP2C9

Patrick M. Dansette , Shigeyuki Kitamura , Gildas Bertho , Daniel Mansuy

ISSX-JSSX joint symposium, Maui (Hawai) USA, novembre 2005, Nov 2005, Wailea, Maui, United States

Poster de conférence hal-03515695v1